Ligand source activities (1 row/activity)





Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
Sel. page Common
name
GPCRdb
ID
#Vendors

Reference
ligand
Fold
selectivity
# Tested
GPCRs
Species

p-value
(-log)
Activity
Type
Activity
Relation
Activity
Value
AssayType

Assay
Description
Source

Mol
weight
Rot
Bonds
H don

H acc

LogP

Smiles

DOI

122227 8160 31 None -97 3 Rat 7.1 pEC50 = 7.1 Functional
Compound was evaluated for agonist activity against B1 receptor in rat ileum longitudinal smooth muscleCompound was evaluated for agonist activity against B1 receptor in rat ileum longitudinal smooth muscle
ChEMBL None None None None 10.1016/S0960-894X(97)10042-7
3825 8160 31 None -97 3 Rat 7.1 pEC50 = 7.1 Functional
Compound was evaluated for agonist activity against B1 receptor in rat ileum longitudinal smooth muscleCompound was evaluated for agonist activity against B1 receptor in rat ileum longitudinal smooth muscle
ChEMBL None None None None 10.1016/S0960-894X(97)10042-7
644 8160 31 None -97 3 Rat 7.1 pEC50 = 7.1 Functional
Compound was evaluated for agonist activity against B1 receptor in rat ileum longitudinal smooth muscleCompound was evaluated for agonist activity against B1 receptor in rat ileum longitudinal smooth muscle
ChEMBL None None None None 10.1016/S0960-894X(97)10042-7
CHEMBL264100 8160 31 None -97 3 Rat 7.1 pEC50 = 7.1 Functional
Compound was evaluated for agonist activity against B1 receptor in rat ileum longitudinal smooth muscleCompound was evaluated for agonist activity against B1 receptor in rat ileum longitudinal smooth muscle
ChEMBL None None None None 10.1016/S0960-894X(97)10042-7
44323260 113792 0 None - 1 Rat 6.0 pEC50 = 6.0 Functional
Compound was evaluated for agonist activity against B1 receptor in rat ileum longitudinal smooth muscleCompound was evaluated for agonist activity against B1 receptor in rat ileum longitudinal smooth muscle
ChEMBL 845 32 10 10 0.7 NCCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCCCCCCCCCCCCC(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/S0960-894X(97)10042-7
CHEMBL315388 113792 0 None - 1 Rat 6.0 pEC50 = 6.0 Functional
Compound was evaluated for agonist activity against B1 receptor in rat ileum longitudinal smooth muscleCompound was evaluated for agonist activity against B1 receptor in rat ileum longitudinal smooth muscle
ChEMBL 845 32 10 10 0.7 NCCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCCCCCCCCCCCCC(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/S0960-894X(97)10042-7
11757682 128818 0 None - 1 Human 10.4 pIC50 = 10.4 Functional
Antagonist activity against human Bradykinin receptor B1 was determined in a fluorescence imaging plate reader assayAntagonist activity against human Bradykinin receptor B1 was determined in a fluorescence imaging plate reader assay
ChEMBL 567 8 3 6 3.5 O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc2ccccc2c1)NCCc1ccc(C2=NCCN2)cc1 10.1016/j.bmcl.2004.09.074
CHEMBL359553 128818 0 None - 1 Human 10.4 pIC50 = 10.4 Functional
Antagonist activity against human Bradykinin receptor B1 was determined in a fluorescence imaging plate reader assayAntagonist activity against human Bradykinin receptor B1 was determined in a fluorescence imaging plate reader assay
ChEMBL 567 8 3 6 3.5 O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc2ccccc2c1)NCCc1ccc(C2=NCCN2)cc1 10.1016/j.bmcl.2004.09.074
11214480 155958 0 None - 1 Human 10.1 pIC50 = 10.1 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 514 7 4 5 4.3 O=C(Nc1[nH]nc(C(=O)Nc2ccc(CCC3=NCCN3)cc2)c1Br)c1ccccc1Cl 10.1021/jm051292n
CHEMBL394370 155958 0 None - 1 Human 10.1 pIC50 = 10.1 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 514 7 4 5 4.3 O=C(Nc1[nH]nc(C(=O)Nc2ccc(CCC3=NCCN3)cc2)c1Br)c1ccccc1Cl 10.1021/jm051292n
57397292 76834 0 None - 1 Human 10.1 pIC50 = 10.1 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 522 7 2 5 3.1 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCC4)ccc32)cc1 10.1016/j.bmcl.2011.11.112
CHEMBL1939758 76834 0 None - 1 Human 10.1 pIC50 = 10.1 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 522 7 2 5 3.1 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCC4)ccc32)cc1 10.1016/j.bmcl.2011.11.112
54772237 72557 0 None 6 2 Human 10.1 pIC50 = 10.1 Functional
Antagonist activity at human B1 receptor expressed in CHO cells by aequorin-based calcium flux assayAntagonist activity at human B1 receptor expressed in CHO cells by aequorin-based calcium flux assay
ChEMBL 525 5 1 6 5.0 Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cn2)c(=O)c2c(F)cccc12 10.1021/jm200808v
CHEMBL1834752 72557 0 None 6 2 Human 10.1 pIC50 = 10.1 Functional
Antagonist activity at human B1 receptor expressed in CHO cells by aequorin-based calcium flux assayAntagonist activity at human B1 receptor expressed in CHO cells by aequorin-based calcium flux assay
ChEMBL 525 5 1 6 5.0 Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cn2)c(=O)c2c(F)cccc12 10.1021/jm200808v
60142570 132693 0 None - 1 Human 10.0 pIC50 = 10 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 532 6 2 7 4.4 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)c3cncnc3)CC2)no1 nan
CHEMBL3648475 132693 0 None - 1 Human 10.0 pIC50 = 10 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 532 6 2 7 4.4 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)c3cncnc3)CC2)no1 nan
60142706 132698 0 None - 1 Human 10.0 pIC50 = 10 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 551 7 2 8 4.6 COc1cc(C(=O)NC2(C(=O)N[C@H]3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)ccc43)CC2)on1 nan
CHEMBL3648480 132698 0 None - 1 Human 10.0 pIC50 = 10 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 551 7 2 8 4.6 COc1cc(C(=O)NC2(C(=O)N[C@H]3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)ccc43)CC2)on1 nan
11570120 76831 0 None - 1 Human 9.9 pIC50 = 9.9 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 536 7 2 5 3.5 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2011.11.112
CHEMBL1939755 76831 0 None - 1 Human 9.9 pIC50 = 9.9 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 536 7 2 5 3.5 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2011.11.112
24970287 195202 0 None - 1 Human 9.9 pIC50 = 9.9 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cellsAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells
ChEMBL 574 7 2 6 4.2 O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccccc1)N[C@@H]1CCOc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2008.07.055
CHEMBL502140 195202 0 None - 1 Human 9.9 pIC50 = 9.9 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cellsAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells
ChEMBL 574 7 2 6 4.2 O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccccc1)N[C@@H]1CCOc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2008.07.055
46230121 208923 0 None - 1 Human 9.9 pIC50 = 9.9 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 546 7 2 9 3.3 CCN(NC(=O)c1cc(OC)no1)C(=O)NCc1ccc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F 10.1016/j.bmcl.2009.11.119
CHEMBL609157 208923 0 None - 1 Human 9.9 pIC50 = 9.9 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 546 7 2 9 3.3 CCN(NC(=O)c1cc(OC)no1)C(=O)NCc1ccc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F 10.1016/j.bmcl.2009.11.119
46230161 208199 0 None - 1 Human 9.9 pIC50 = 9.9 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 561 7 2 10 3.3 CCN(NC(=O)c1cc(OC)no1)C(=O)N[C@H](C)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F 10.1016/j.bmcl.2009.11.119
CHEMBL604735 208199 0 None - 1 Human 9.9 pIC50 = 9.9 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 561 7 2 10 3.3 CCN(NC(=O)c1cc(OC)no1)C(=O)N[C@H](C)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F 10.1016/j.bmcl.2009.11.119
54582655 68970 0 None - 1 Human 9.9 pIC50 = 9.9 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 552 7 2 5 3.3 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCC(C)CC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
CHEMBL1777969 68970 0 None - 1 Human 9.9 pIC50 = 9.9 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 552 7 2 5 3.3 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCC(C)CC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
44587189 179220 0 None - 1 Human 9.9 pIC50 = 9.9 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cellsAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells
ChEMBL 588 7 2 6 4.5 Cc1ccc(S(=O)(=O)N2c3ccccc3NC(=O)[C@H]2CC(=O)N[C@@H]2CCOc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2008.07.055
CHEMBL447870 179220 0 None - 1 Human 9.9 pIC50 = 9.9 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cellsAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells
ChEMBL 588 7 2 6 4.5 Cc1ccc(S(=O)(=O)N2c3ccccc3NC(=O)[C@H]2CC(=O)N[C@@H]2CCOc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2008.07.055
56594769 72500 0 None 6 2 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at human B1 receptor expressed in CHO cells by aequorin-based calcium flux assayAntagonist activity at human B1 receptor expressed in CHO cells by aequorin-based calcium flux assay
ChEMBL 541 5 1 6 5.5 Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cn2)c(=O)c2c(Cl)cccc12 10.1021/jm200808v
CHEMBL1834619 72500 0 None 6 2 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at human B1 receptor expressed in CHO cells by aequorin-based calcium flux assayAntagonist activity at human B1 receptor expressed in CHO cells by aequorin-based calcium flux assay
ChEMBL 541 5 1 6 5.5 Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cn2)c(=O)c2c(Cl)cccc12 10.1021/jm200808v
665 7760 3 None 1 4 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cellsAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells
ChEMBL 585 8 3 6 3.6 O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 10.1016/j.bmcl.2008.07.055
9916412 7760 3 None 1 4 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cellsAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells
ChEMBL 585 8 3 6 3.6 O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 10.1016/j.bmcl.2008.07.055
CHEMBL189123 7760 3 None 1 4 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cellsAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells
ChEMBL 585 8 3 6 3.6 O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 10.1016/j.bmcl.2008.07.055
665 7760 3 None 1 4 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at human bradykinin B1 receptor in human MR5 cells assessed as [3H]inositol phosphate accumulationAntagonist activity at human bradykinin B1 receptor in human MR5 cells assessed as [3H]inositol phosphate accumulation
ChEMBL 585 8 3 6 3.6 O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 10.1021/jm1000776
9916412 7760 3 None 1 4 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at human bradykinin B1 receptor in human MR5 cells assessed as [3H]inositol phosphate accumulationAntagonist activity at human bradykinin B1 receptor in human MR5 cells assessed as [3H]inositol phosphate accumulation
ChEMBL 585 8 3 6 3.6 O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 10.1021/jm1000776
CHEMBL189123 7760 3 None 1 4 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at human bradykinin B1 receptor in human MR5 cells assessed as [3H]inositol phosphate accumulationAntagonist activity at human bradykinin B1 receptor in human MR5 cells assessed as [3H]inositol phosphate accumulation
ChEMBL 585 8 3 6 3.6 O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 10.1021/jm1000776
46216675 207388 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 513 5 2 7 4.3 Cn1nnc(-c2c(F)cc(Cl)cc2-c2cnc(CNC(=O)N(O)C3CCC(F)(F)CC3)c(F)c2)n1 10.1016/j.bmcl.2009.11.121
CHEMBL599285 207388 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 513 5 2 7 4.3 Cn1nnc(-c2c(F)cc(Cl)cc2-c2cnc(CNC(=O)N(O)C3CCC(F)(F)CC3)c(F)c2)n1 10.1016/j.bmcl.2009.11.121
46230160 207360 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 547 7 2 10 2.7 CCN(NC(=O)c1cc(OC)no1)C(=O)NCc1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F 10.1016/j.bmcl.2009.11.119
CHEMBL599153 207360 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 547 7 2 10 2.7 CCN(NC(=O)c1cc(OC)no1)C(=O)NCc1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F 10.1016/j.bmcl.2009.11.119
11387387 68968 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 558 7 2 5 3.4 O=C(C[C@@H]1C(=O)NCCN1S(=O)(=O)c1ccc(Cl)cc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2011.03.115
CHEMBL1777967 68968 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 558 7 2 5 3.4 O=C(C[C@@H]1C(=O)NCCN1S(=O)(=O)c1ccc(Cl)cc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2011.03.115
57523216 132694 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 562 7 2 8 4.4 COc1ncc(C(=O)NC2(C(=O)N[C@H]3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)ccc43)CC2)cn1 nan
CHEMBL3648476 132694 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 562 7 2 8 4.4 COc1ncc(C(=O)NC2(C(=O)N[C@H]3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)ccc43)CC2)cn1 nan
60142962 132706 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 552 7 2 9 4.0 COc1cc(C(=O)NC2(C(=O)NC3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)cnc43)CC2)on1 nan
CHEMBL3648488 132706 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 552 7 2 9 4.0 COc1cc(C(=O)NC2(C(=O)NC3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)cnc43)CC2)on1 nan
60142963 132707 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 533 6 2 8 3.8 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)c3ccnnc3)CC2)no1 nan
CHEMBL3648489 132707 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 533 6 2 8 3.8 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)c3ccnnc3)CC2)no1 nan
60143095 132708 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 563 7 2 9 3.8 COc1ncc(C(=O)NC2(C(=O)NC3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)cnc43)CC2)cn1 nan
CHEMBL3648490 132708 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 563 7 2 9 3.8 COc1ncc(C(=O)NC2(C(=O)NC3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)cnc43)CC2)cn1 nan
60141038 132712 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 564 7 2 9 3.8 COc1ncc(C(=O)NC2(C(=O)NC3COc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)ccc43)CC2)cn1 nan
CHEMBL3648494 132712 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 564 7 2 9 3.8 COc1ncc(C(=O)NC2(C(=O)NC3COc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)ccc43)CC2)cn1 nan
60141185 132720 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 563 7 2 10 2.6 COc1ncc(C(=O)NC2(C(=O)NC3CCc4cc(-c5cc(Cl)cc(F)c5-c5nnn(C)n5)cnc43)CC2)cn1 nan
CHEMBL3648502 132720 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 563 7 2 10 2.6 COc1ncc(C(=O)NC2(C(=O)NC3CCc4cc(-c5cc(Cl)cc(F)c5-c5nnn(C)n5)cnc43)CC2)cn1 nan
60141464 132726 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 550 6 2 9 3.4 Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)SCC3NC(=O)C2(NC(=O)c3cncnc3)CC2)n1 nan
CHEMBL3648508 132726 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 550 6 2 9 3.4 Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)SCC3NC(=O)C2(NC(=O)c3cncnc3)CC2)n1 nan
60141466 132728 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 569 7 2 10 3.6 COc1cc(C(=O)NC2(C(=O)NC3CSc4cc(-c5cc(Cl)cc(F)c5-c5nnn(C)n5)ccc43)CC2)on1 nan
CHEMBL3648510 132728 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 569 7 2 10 3.6 COc1cc(C(=O)NC2(C(=O)NC3CSc4cc(-c5cc(Cl)cc(F)c5-c5nnn(C)n5)ccc43)CC2)on1 nan
57398978 76833 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 496 7 2 5 2.6 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN(C)C)ccc32)cc1 10.1016/j.bmcl.2011.11.112
CHEMBL1939757 76833 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 496 7 2 5 2.6 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN(C)C)ccc32)cc1 10.1016/j.bmcl.2011.11.112
53248885 68959 0 None 18 2 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 538 7 2 5 3.1 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
CHEMBL1777958 68959 0 None 18 2 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 538 7 2 5 3.1 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
53248885 68959 0 None 18 2 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 538 7 2 5 3.1 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2011.11.112
CHEMBL1777958 68959 0 None 18 2 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 538 7 2 5 3.1 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2011.11.112
57396447 76879 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 488 5 2 5 2.2 CN1CC[C@H](NC(=O)C[C@@H]2C(=O)NC=CN2S(=O)(=O)c2cccc(Cl)c2Cl)C(C)(C)C1 10.1016/j.bmcl.2011.11.112
CHEMBL1939944 76879 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 488 5 2 5 2.2 CN1CC[C@H](NC(=O)C[C@@H]2C(=O)NC=CN2S(=O)(=O)c2cccc(Cl)c2Cl)C(C)(C)C1 10.1016/j.bmcl.2011.11.112
57400696 76835 0 None - 1 Human 9.6 pIC50 = 9.6 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 508 8 3 5 2.8 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC4CC4)ccc32)cc1 10.1016/j.bmcl.2011.11.112
CHEMBL1939759 76835 0 None - 1 Human 9.6 pIC50 = 9.6 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 508 8 3 5 2.8 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC4CC4)ccc32)cc1 10.1016/j.bmcl.2011.11.112
57392941 76874 0 None - 1 Human 9.6 pIC50 = 9.6 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 488 6 2 5 2.5 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@H]2CCN(C3CCCC3)CC2(C)C)cc1 10.1016/j.bmcl.2011.11.112
CHEMBL1939939 76874 0 None - 1 Human 9.6 pIC50 = 9.6 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 488 6 2 5 2.5 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@H]2CCN(C3CCCC3)CC2(C)C)cc1 10.1016/j.bmcl.2011.11.112
11442712 92001 0 None 9 2 Human 9.6 pIC50 = 9.6 Functional
Antagonist activity at bradykinin B1 receptor expressed in CHO cells assessed as inhibition of des-arg10-kallidin-induced increase in cytosolic calcium level by FLIPR assayAntagonist activity at bradykinin B1 receptor expressed in CHO cells assessed as inhibition of des-arg10-kallidin-induced increase in cytosolic calcium level by FLIPR assay
ChEMBL 466 7 2 6 5.4 COC(=O)c1c(F)cccc1-c1ccc([C@@H](C)Nc2nccc(Cl)c2NC(=O)CC#N)cc1 10.1021/jm049394l
CHEMBL225607 92001 0 None 9 2 Human 9.6 pIC50 = 9.6 Functional
Antagonist activity at bradykinin B1 receptor expressed in CHO cells assessed as inhibition of des-arg10-kallidin-induced increase in cytosolic calcium level by FLIPR assayAntagonist activity at bradykinin B1 receptor expressed in CHO cells assessed as inhibition of des-arg10-kallidin-induced increase in cytosolic calcium level by FLIPR assay
ChEMBL 466 7 2 6 5.4 COC(=O)c1c(F)cccc1-c1ccc([C@@H](C)Nc2nccc(Cl)c2NC(=O)CC#N)cc1 10.1021/jm049394l
46230120 205988 0 None - 1 Human 9.6 pIC50 = 9.6 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 547 7 2 9 3.9 CCN(NC(=O)c1cc(OC)no1)C(=O)NCc1ncc(-c2cc(Cl)cc(F)c2-c2noc(C)n2)cc1F 10.1016/j.bmcl.2009.11.119
CHEMBL589820 205988 0 None - 1 Human 9.6 pIC50 = 9.6 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 547 7 2 9 3.9 CCN(NC(=O)c1cc(OC)no1)C(=O)NCc1ncc(-c2cc(Cl)cc(F)c2-c2noc(C)n2)cc1F 10.1016/j.bmcl.2009.11.119
46230203 207428 0 None - 1 Human 9.6 pIC50 = 9.6 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 532 5 2 7 3.6 CCN(NC(=O)C(F)(F)F)C(=O)N[C@H](C)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F 10.1016/j.bmcl.2009.11.119
CHEMBL599574 207428 0 None - 1 Human 9.6 pIC50 = 9.6 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 532 5 2 7 3.6 CCN(NC(=O)C(F)(F)F)C(=O)N[C@H](C)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F 10.1016/j.bmcl.2009.11.119
57395448 76832 0 None - 1 Human 9.6 pIC50 = 9.6 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 468 6 3 5 2.0 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN)ccc32)cc1 10.1016/j.bmcl.2011.11.112
CHEMBL1939756 76832 0 None - 1 Human 9.6 pIC50 = 9.6 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 468 6 3 5 2.0 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN)ccc32)cc1 10.1016/j.bmcl.2011.11.112
57398238 76876 0 None - 1 Human 9.6 pIC50 = 9.6 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 474 5 3 5 1.8 CC1(C)CNCC[C@@H]1NC(=O)C[C@@H]1C(=O)NC=CN1S(=O)(=O)c1cccc(Cl)c1Cl 10.1016/j.bmcl.2011.11.112
CHEMBL1939941 76876 0 None - 1 Human 9.6 pIC50 = 9.6 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 474 5 3 5 1.8 CC1(C)CNCC[C@@H]1NC(=O)C[C@@H]1C(=O)NC=CN1S(=O)(=O)c1cccc(Cl)c1Cl 10.1016/j.bmcl.2011.11.112
57391173 76878 0 None - 1 Human 9.6 pIC50 = 9.6 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 482 5 2 5 2.2 Cc1cc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@H]2CCN(C)CC2(C)C)c(C)cc1Cl 10.1016/j.bmcl.2011.11.112
CHEMBL1939943 76878 0 None - 1 Human 9.6 pIC50 = 9.6 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 482 5 2 5 2.2 Cc1cc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@H]2CCN(C)CC2(C)C)c(C)cc1Cl 10.1016/j.bmcl.2011.11.112
46230404 207138 0 None - 1 Human 9.5 pIC50 = 9.5 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilization
ChEMBL 492 6 2 7 5.2 CC(=O)Nn1c(Cl)cnc1NCc1ccc(-c2cc(Cl)cc(F)c2-c2noc(C)n2)cc1F 10.1016/j.bmcl.2009.11.120
CHEMBL597747 207138 0 None - 1 Human 9.5 pIC50 = 9.5 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilization
ChEMBL 492 6 2 7 5.2 CC(=O)Nn1c(Cl)cnc1NCc1ccc(-c2cc(Cl)cc(F)c2-c2noc(C)n2)cc1F 10.1016/j.bmcl.2009.11.120
56589598 72556 0 None 7 2 Human 9.5 pIC50 = 9.5 Functional
Antagonist activity at human B1 receptor expressed in CHO cells by aequorin-based calcium flux assayAntagonist activity at human B1 receptor expressed in CHO cells by aequorin-based calcium flux assay
ChEMBL 543 5 1 6 5.2 Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cn2)c(=O)c2c(F)ccc(F)c12 10.1021/jm200808v
CHEMBL1834751 72556 0 None 7 2 Human 9.5 pIC50 = 9.5 Functional
Antagonist activity at human B1 receptor expressed in CHO cells by aequorin-based calcium flux assayAntagonist activity at human B1 receptor expressed in CHO cells by aequorin-based calcium flux assay
ChEMBL 543 5 1 6 5.2 Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cn2)c(=O)c2c(F)ccc(F)c12 10.1021/jm200808v
11214819 68951 0 None - 1 Human 9.5 pIC50 = 9.5 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 538 7 2 5 3.1 Cc1ccc(S(=O)(=O)N2CCNC(=O)C2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
CHEMBL1777885 68951 0 None - 1 Human 9.5 pIC50 = 9.5 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 538 7 2 5 3.1 Cc1ccc(S(=O)(=O)N2CCNC(=O)C2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
60142704 132696 0 None - 1 Human 9.5 pIC50 = 9.5 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 521 6 2 7 4.6 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)c3ccno3)CC2)no1 nan
CHEMBL3648478 132696 0 None - 1 Human 9.5 pIC50 = 9.5 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 521 6 2 7 4.6 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)c3ccno3)CC2)no1 nan
60143096 132709 0 None - 1 Human 9.5 pIC50 = 9.5 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 522 6 2 8 4.0 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)c3ccno3)CC2)no1 nan
CHEMBL3648491 132709 0 None - 1 Human 9.5 pIC50 = 9.5 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 522 6 2 8 4.0 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)c3ccno3)CC2)no1 nan
60141324 132723 0 None - 1 Human 9.5 pIC50 = 9.5 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 552 7 2 10 2.8 COc1cc(C(=O)NC2(C(=O)NC3CCc4cc(-c5cc(Cl)cc(F)c5-c5nnn(C)n5)cnc43)CC2)on1 nan
CHEMBL3648505 132723 0 None - 1 Human 9.5 pIC50 = 9.5 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 552 7 2 10 2.8 COc1cc(C(=O)NC2(C(=O)NC3CCc4cc(-c5cc(Cl)cc(F)c5-c5nnn(C)n5)cnc43)CC2)on1 nan
57401664 76877 0 None - 1 Human 9.5 pIC50 = 9.5 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 468 5 3 5 1.8 Cc1cc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@H]2CCNCC2(C)C)c(C)cc1Cl 10.1016/j.bmcl.2011.11.112
CHEMBL1939942 76877 0 None - 1 Human 9.5 pIC50 = 9.5 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 468 5 3 5 1.8 Cc1cc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@H]2CCNCC2(C)C)c(C)cc1Cl 10.1016/j.bmcl.2011.11.112
11342704 68957 0 None - 1 Human 9.5 pIC50 = 9.5 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 642 7 2 6 4.2 O=C(CC1C(=O)NCCN1S(=O)(=O)c1sc(Cl)cc1Br)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2011.03.115
CHEMBL1777956 68957 0 None - 1 Human 9.5 pIC50 = 9.5 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 642 7 2 6 4.2 O=C(CC1C(=O)NCCN1S(=O)(=O)c1sc(Cl)cc1Br)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2011.03.115
54586519 68978 0 None - 1 Human 9.5 pIC50 = 9.5 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 524 9 3 5 2.6 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNCC4CC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
CHEMBL1777977 68978 0 None - 1 Human 9.5 pIC50 = 9.5 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 524 9 3 5 2.6 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNCC4CC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
44587188 200150 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cellsAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells
ChEMBL 562 7 3 6 4.1 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccccc1 10.1016/j.bmcl.2008.07.055
CHEMBL525092 200150 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cellsAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells
ChEMBL 562 7 3 6 4.1 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccccc1 10.1016/j.bmcl.2008.07.055
54583617 68969 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 540 7 2 6 2.5 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCOc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
CHEMBL1777968 68969 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 540 7 2 6 2.5 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCOc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
57390218 76836 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 538 8 3 5 3.7 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNCC(C)(C)C)ccc32)cc1 10.1016/j.bmcl.2011.11.112
CHEMBL1939760 76836 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 538 8 3 5 3.7 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNCC(C)(C)C)ccc32)cc1 10.1016/j.bmcl.2011.11.112
16108961 7710 0 None 2 3 Human 9.4 pIC50 = 9.4 Functional
Antagonistic activity at African green monkey bradykinin B1 receptor assessed as effect on DAK-mediated calcium mobilizationAntagonistic activity at African green monkey bradykinin B1 receptor assessed as effect on DAK-mediated calcium mobilization
ChEMBL 583 9 2 5 5.9 O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 10.1021/jm061224g
664 7710 0 None 2 3 Human 9.4 pIC50 = 9.4 Functional
Antagonistic activity at African green monkey bradykinin B1 receptor assessed as effect on DAK-mediated calcium mobilizationAntagonistic activity at African green monkey bradykinin B1 receptor assessed as effect on DAK-mediated calcium mobilization
ChEMBL 583 9 2 5 5.9 O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 10.1021/jm061224g
CHEMBL415848 7710 0 None 2 3 Human 9.4 pIC50 = 9.4 Functional
Antagonistic activity at African green monkey bradykinin B1 receptor assessed as effect on DAK-mediated calcium mobilizationAntagonistic activity at African green monkey bradykinin B1 receptor assessed as effect on DAK-mediated calcium mobilization
ChEMBL 583 9 2 5 5.9 O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 10.1021/jm061224g
60142703 132695 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 532 6 2 7 4.4 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)c3ccnnc3)CC2)no1 nan
CHEMBL3648477 132695 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 532 6 2 7 4.4 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)c3ccnnc3)CC2)no1 nan
60141041 132714 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 548 6 2 8 3.6 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)c3cncnc3)COC2)no1 nan
CHEMBL3648496 132714 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 548 6 2 8 3.6 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)c3cncnc3)COC2)no1 nan
60141182 132717 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 567 7 2 9 3.8 COc1cc(C(=O)NC2(C(=O)N[C@H]3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)ccc43)COC2)on1 nan
CHEMBL3648499 132717 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 567 7 2 9 3.8 COc1cc(C(=O)NC2(C(=O)N[C@H]3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)ccc43)COC2)on1 nan
71229238 132721 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 522 6 2 9 2.8 Cn1nnc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)c3ccno3)CC2)n1 nan
CHEMBL3648503 132721 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 522 6 2 9 2.8 Cn1nnc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)c3ccno3)CC2)n1 nan
60141323 132722 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 536 6 2 9 3.1 Cc1cc(C(=O)NC2(C(=O)NC3CCc4cc(-c5cc(Cl)cc(F)c5-c5nnn(C)n5)cnc43)CC2)on1 nan
CHEMBL3648504 132722 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 536 6 2 9 3.1 Cc1cc(C(=O)NC2(C(=O)NC3CCc4cc(-c5cc(Cl)cc(F)c5-c5nnn(C)n5)cnc43)CC2)on1 nan
57392940 76866 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 434 5 2 5 1.2 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@H]2CCN(C)CC2(C)C)cc1 10.1016/j.bmcl.2011.11.112
CHEMBL1939931 76866 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 434 5 2 5 1.2 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@H]2CCN(C)CC2(C)C)cc1 10.1016/j.bmcl.2011.11.112
46230119 205987 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 546 7 2 8 4.5 CCN(NC(=O)c1cc(OC)no1)C(=O)NCc1ccc(-c2cc(Cl)cc(F)c2-c2noc(C)n2)cc1F 10.1016/j.bmcl.2009.11.119
CHEMBL589819 205987 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 546 7 2 8 4.5 CCN(NC(=O)c1cc(OC)no1)C(=O)NCc1ccc(-c2cc(Cl)cc(F)c2-c2noc(C)n2)cc1F 10.1016/j.bmcl.2009.11.119
54581635 68952 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 554 8 2 6 2.8 COc1ccc(S(=O)(=O)N2CCNC(=O)C2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
CHEMBL1777886 68952 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 554 8 2 6 2.8 COc1ccc(S(=O)(=O)N2CCNC(=O)C2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
53360054 76864 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 420 5 3 5 0.9 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@H]2CCNCC2(C)C)cc1 10.1016/j.bmcl.2011.11.112
CHEMBL1939929 76864 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 420 5 3 5 0.9 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@H]2CCNCC2(C)C)cc1 10.1016/j.bmcl.2011.11.112
16747694 94728 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity in human bradykinin B1 receptor by FLIPR methodAntagonist activity in human bradykinin B1 receptor by FLIPR method
ChEMBL 469 6 2 6 5.4 N#CC1(c2ccccc2C(F)(F)F)CCC(CNc2ncccc2NC(=O)c2ccno2)CC1 10.1016/j.bmcl.2007.03.059
CHEMBL234097 94728 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity in human bradykinin B1 receptor by FLIPR methodAntagonist activity in human bradykinin B1 receptor by FLIPR method
ChEMBL 469 6 2 6 5.4 N#CC1(c2ccccc2C(F)(F)F)CCC(CNc2ncccc2NC(=O)c2ccno2)CC1 10.1016/j.bmcl.2007.03.059
46230163 207189 0 None - 1 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 532 5 2 6 4.7 CCN(NC(=O)C(F)(F)F)C(=O)N[C@H](C)c1ncc(-c2cc(Cl)cc(F)c2-c2noc(C)n2)cc1F 10.1016/j.bmcl.2009.11.119
CHEMBL598124 207189 0 None - 1 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 532 5 2 6 4.7 CCN(NC(=O)C(F)(F)F)C(=O)N[C@H](C)c1ncc(-c2cc(Cl)cc(F)c2-c2noc(C)n2)cc1F 10.1016/j.bmcl.2009.11.119
11364466 68947 0 None - 1 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 524 7 2 5 2.7 O=C(CC1C(=O)NCCN1S(=O)(=O)c1ccccc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2011.03.115
CHEMBL1777881 68947 0 None - 1 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 524 7 2 5 2.7 O=C(CC1C(=O)NCCN1S(=O)(=O)c1ccccc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2011.03.115
11341479 68979 0 None - 1 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 526 9 3 5 2.8 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNCC(C)C)ccc32)cc1 10.1016/j.bmcl.2011.03.115
CHEMBL1777978 68979 0 None - 1 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 526 9 3 5 2.8 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNCC(C)C)ccc32)cc1 10.1016/j.bmcl.2011.03.115
44587186 179497 0 None - 1 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cellsAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells
ChEMBL 642 7 2 6 5.5 O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)N[C@@H]1CCOc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2008.07.055
CHEMBL450541 179497 0 None - 1 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cellsAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells
ChEMBL 642 7 2 6 5.5 O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)N[C@@H]1CCOc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2008.07.055
54587514 68949 0 None - 1 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 558 7 2 5 3.4 O=C(CC1C(=O)NCCN1S(=O)(=O)c1ccc(Cl)cc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2011.03.115
CHEMBL1777883 68949 0 None - 1 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 558 7 2 5 3.4 O=C(CC1C(=O)NCCN1S(=O)(=O)c1ccc(Cl)cc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2011.03.115
46230990 207419 0 None - 1 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 473 7 2 7 3.1 Cn1nnc(-c2c(F)cc(Cl)cc2-c2cnc(CNC(=O)N(O)C(CF)CF)c(F)c2)n1 10.1016/j.bmcl.2009.11.121
CHEMBL599490 207419 0 None - 1 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 473 7 2 7 3.1 Cn1nnc(-c2c(F)cc(Cl)cc2-c2cnc(CNC(=O)N(O)C(CF)CF)c(F)c2)n1 10.1016/j.bmcl.2009.11.121
60142303 132680 0 None - 1 Human 9.3 pIC50 = 9.3 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 523 5 2 6 4.2 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 nan
CHEMBL3648462 132680 0 None - 1 Human 9.3 pIC50 = 9.3 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 523 5 2 6 4.2 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 nan
60142304 132681 0 None - 1 Human 9.3 pIC50 = 9.3 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 523 5 2 7 3.0 Cn1nnc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)n1 nan
CHEMBL3648463 132681 0 None - 1 Human 9.3 pIC50 = 9.3 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 523 5 2 7 3.0 Cn1nnc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)n1 nan
60142437 132684 0 None - 1 Human 9.3 pIC50 = 9.3 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 540 5 2 5 5.0 Cc1nc(-c2c(F)cc(Cl)cc2-c2cc(F)c3c(c2)CCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 nan
CHEMBL3648466 132684 0 None - 1 Human 9.3 pIC50 = 9.3 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 540 5 2 5 5.0 Cc1nc(-c2c(F)cc(Cl)cc2-c2cc(F)c3c(c2)CCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 nan
60142440 132686 0 None - 1 Human 9.3 pIC50 = 9.3 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 536 5 2 6 3.8 Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CCC3(C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)n1 nan
CHEMBL3648468 132686 0 None - 1 Human 9.3 pIC50 = 9.3 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 536 5 2 6 3.8 Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CCC3(C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)n1 nan
60142834 132701 0 None - 1 Human 9.3 pIC50 = 9.3 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 580 7 2 8 4.5 COc1ncc(C(=O)NC2(C(=O)NC3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)cc(F)c43)CC2)cn1 nan
CHEMBL3648483 132701 0 None - 1 Human 9.3 pIC50 = 9.3 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 580 7 2 8 4.5 COc1ncc(C(=O)NC2(C(=O)NC3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)cc(F)c43)CC2)cn1 nan
60142836 132703 0 None - 1 Human 9.3 pIC50 = 9.3 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 569 7 2 8 4.7 COc1cc(C(=O)NC2(C(=O)NC3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)cc(F)c43)CC2)on1 nan
CHEMBL3648485 132703 0 None - 1 Human 9.3 pIC50 = 9.3 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 569 7 2 8 4.7 COc1cc(C(=O)NC2(C(=O)NC3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)cc(F)c43)CC2)on1 nan
60141465 132727 0 None - 1 Human 9.3 pIC50 = 9.3 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 539 6 2 9 3.6 Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)SCC3NC(=O)C2(NC(=O)c3ccno3)CC2)n1 nan
CHEMBL3648509 132727 0 None - 1 Human 9.3 pIC50 = 9.3 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 539 6 2 9 3.6 Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)SCC3NC(=O)C2(NC(=O)c3ccno3)CC2)n1 nan
57398235 76868 0 None - 1 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 462 7 2 5 2.0 CCCN1CC[C@H](NC(=O)C[C@@H]2C(=O)NC=CN2S(=O)(=O)c2ccc(C)cc2)C(C)(C)C1 10.1016/j.bmcl.2011.11.112
CHEMBL1939933 76868 0 None - 1 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 462 7 2 5 2.0 CCCN1CC[C@H](NC(=O)C[C@@H]2C(=O)NC=CN2S(=O)(=O)c2ccc(C)cc2)C(C)(C)C1 10.1016/j.bmcl.2011.11.112
11168954 68948 0 None - 1 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 558 7 2 5 3.4 O=C(CC1C(=O)NCCN1S(=O)(=O)c1ccccc1Cl)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2011.03.115
CHEMBL1777882 68948 0 None - 1 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 558 7 2 5 3.4 O=C(CC1C(=O)NCCN1S(=O)(=O)c1ccccc1Cl)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2011.03.115
44587187 195490 0 None - 1 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 640 7 2 5 6.1 O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2011.03.115
CHEMBL504531 195490 0 None - 1 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 640 7 2 5 6.1 O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2011.03.115
44587187 195490 0 None - 1 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cellsAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells
ChEMBL 640 7 2 5 6.1 O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2008.07.055
CHEMBL504531 195490 0 None - 1 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cellsAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells
ChEMBL 640 7 2 5 6.1 O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2008.07.055
46216847 207219 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilization
ChEMBL 559 8 2 11 5.4 COc1cc(C(=O)Nc2nsnc2NCc2ccc(-c3cc(Cl)cc(F)c3-c3noc(C)n3)cc2F)on1 10.1016/j.bmcl.2009.11.120
CHEMBL598349 207219 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilization
ChEMBL 559 8 2 11 5.4 COc1cc(C(=O)Nc2nsnc2NCc2ccc(-c3cc(Cl)cc(F)c3-c3noc(C)n3)cc2F)on1 10.1016/j.bmcl.2009.11.120
54581667 68976 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 538 8 3 5 3.1 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC4CCCC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
CHEMBL1777975 68976 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 538 8 3 5 3.1 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC4CCCC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
60142028 132672 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 522 5 2 5 4.8 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 nan
CHEMBL3648455 132672 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 522 5 2 5 4.8 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 nan
60142438 132685 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 536 5 2 5 5.0 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CCC3(C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 nan
CHEMBL3648467 132685 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 536 5 2 5 5.0 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CCC3(C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 nan
60142835 132702 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 550 6 2 7 4.5 Cc1nc(-c2c(F)cc(Cl)cc2-c2cc(F)c3c(c2)CCC3NC(=O)C2(NC(=O)c3ccnnc3)CC2)no1 nan
CHEMBL3648484 132702 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 550 6 2 7 4.5 Cc1nc(-c2c(F)cc(Cl)cc2-c2cc(F)c3c(c2)CCC3NC(=O)C2(NC(=O)c3ccnnc3)CC2)no1 nan
60142963 132707 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 533 6 2 8 3.8 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)c3ccnnc3)CC2)no1 nan
CHEMBL3648489 132707 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 533 6 2 8 3.8 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)c3ccnnc3)CC2)no1 nan
54772237 72557 0 None -6 2 Rabbit 9.2 pIC50 = 9.2 Functional
Inhibition of rabbit B1 receptor by cellular calcium flux assayInhibition of rabbit B1 receptor by cellular calcium flux assay
ChEMBL 525 5 1 6 5.0 Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cn2)c(=O)c2c(F)cccc12 10.1021/jm200808v
CHEMBL1834752 72557 0 None -6 2 Rabbit 9.2 pIC50 = 9.2 Functional
Inhibition of rabbit B1 receptor by cellular calcium flux assayInhibition of rabbit B1 receptor by cellular calcium flux assay
ChEMBL 525 5 1 6 5.0 Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cn2)c(=O)c2c(F)cccc12 10.1021/jm200808v
57396446 76867 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 448 6 2 5 1.6 CCN1CC[C@H](NC(=O)C[C@@H]2C(=O)NC=CN2S(=O)(=O)c2ccc(C)cc2)C(C)(C)C1 10.1016/j.bmcl.2011.11.112
CHEMBL1939932 76867 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 448 6 2 5 1.6 CCN1CC[C@H](NC(=O)C[C@@H]2C(=O)NC=CN2S(=O)(=O)c2ccc(C)cc2)C(C)(C)C1 10.1016/j.bmcl.2011.11.112
46230202 207041 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 548 5 2 7 4.1 CCN(NC(=O)C(F)(F)F)C(=O)N[C@H](C)c1ncc(-c2cc(Cl)cc(Cl)c2-c2nnn(C)n2)cc1F 10.1016/j.bmcl.2009.11.119
CHEMBL597115 207041 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 548 5 2 7 4.1 CCN(NC(=O)C(F)(F)F)C(=O)N[C@H](C)c1ncc(-c2cc(Cl)cc(Cl)c2-c2nnn(C)n2)cc1F 10.1016/j.bmcl.2009.11.119
54581634 68950 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 592 7 2 5 4.1 O=C(CC1C(=O)NCCN1S(=O)(=O)c1ccc(Cl)cc1Cl)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2011.03.115
CHEMBL1777884 68950 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 592 7 2 5 4.1 O=C(CC1C(=O)NCCN1S(=O)(=O)c1ccc(Cl)cc1Cl)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2011.03.115
10239095 90690 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Activity at human bradykinin B1 receptor assessed as inhibition of Des-arg kallidin-induced increase of cytosolic calcium in CHO cells by FLIPRActivity at human bradykinin B1 receptor assessed as inhibition of Des-arg kallidin-induced increase of cytosolic calcium in CHO cells by FLIPR
ChEMBL 494 6 2 6 3.2 C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)CC1)c1ccc(-c2cccc(F)c2-c2nnn(C)n2)cc1F 10.1021/jm061094b
CHEMBL220657 90690 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Activity at human bradykinin B1 receptor assessed as inhibition of Des-arg kallidin-induced increase of cytosolic calcium in CHO cells by FLIPRActivity at human bradykinin B1 receptor assessed as inhibition of Des-arg kallidin-induced increase of cytosolic calcium in CHO cells by FLIPR
ChEMBL 494 6 2 6 3.2 C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)CC1)c1ccc(-c2cccc(F)c2-c2nnn(C)n2)cc1F 10.1021/jm061094b
57398237 76875 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 474 5 3 5 1.8 CC1(C)CNCC[C@@H]1NC(=O)C[C@@H]1C(=O)NC=CN1S(=O)(=O)c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2011.11.112
CHEMBL1939940 76875 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 474 5 3 5 1.8 CC1(C)CNCC[C@@H]1NC(=O)C[C@@H]1C(=O)NC=CN1S(=O)(=O)c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2011.11.112
46230309 206256 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilization
ChEMBL 591 8 2 10 6.0 COc1cc(C(=O)Nn2c(NCc3ccc(-c4cc(Cl)cc(F)c4-c4noc(C)n4)cc3F)nc3ccccc32)on1 10.1016/j.bmcl.2009.11.120
CHEMBL591676 206256 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilization
ChEMBL 591 8 2 10 6.0 COc1cc(C(=O)Nn2c(NCc3ccc(-c4cc(Cl)cc(F)c4-c4noc(C)n4)cc3F)nc3ccccc32)on1 10.1016/j.bmcl.2009.11.120
57398236 76873 0 None - 1 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 474 6 2 5 2.1 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@H]2CCN(C3CCC3)CC2(C)C)cc1 10.1016/j.bmcl.2011.11.112
CHEMBL1939938 76873 0 None - 1 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 474 6 2 5 2.1 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@H]2CCN(C3CCC3)CC2(C)C)cc1 10.1016/j.bmcl.2011.11.112
11477390 91936 0 None - 1 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity at bradykinin B1 receptor expressed in CHO cells assessed as inhibition of des-arg10-kallidin-induced increase in cytosolic calcium level by FLIPR assayAntagonist activity at bradykinin B1 receptor expressed in CHO cells assessed as inhibition of des-arg10-kallidin-induced increase in cytosolic calcium level by FLIPR assay
ChEMBL 490 7 2 7 5.9 Cc1nc(-c2c(F)cccc2-c2ccc([C@@H](C)Nc3nccc(Cl)c3NC(=O)CC#N)cc2)no1 10.1021/jm049394l
CHEMBL225218 91936 0 None - 1 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity at bradykinin B1 receptor expressed in CHO cells assessed as inhibition of des-arg10-kallidin-induced increase in cytosolic calcium level by FLIPR assayAntagonist activity at bradykinin B1 receptor expressed in CHO cells assessed as inhibition of des-arg10-kallidin-induced increase in cytosolic calcium level by FLIPR assay
ChEMBL 490 7 2 7 5.9 Cc1nc(-c2c(F)cccc2-c2ccc([C@@H](C)Nc3nccc(Cl)c3NC(=O)CC#N)cc2)no1 10.1021/jm049394l
46230941 208041 0 None - 1 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 463 5 2 7 3.7 Cn1nnc(-c2c(F)cc(Cl)cc2-c2cnc(CNC(=O)N(O)C3CCCC3)c(F)c2)n1 10.1016/j.bmcl.2009.11.121
CHEMBL603907 208041 0 None - 1 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 463 5 2 7 3.7 Cn1nnc(-c2c(F)cc(Cl)cc2-c2cnc(CNC(=O)N(O)C3CCCC3)c(F)c2)n1 10.1016/j.bmcl.2009.11.121
54587552 68967 0 None - 1 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 524 7 2 5 2.7 O=C(C[C@@H]1C(=O)NCCN1S(=O)(=O)c1ccccc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2011.03.115
CHEMBL1777966 68967 0 None - 1 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 524 7 2 5 2.7 O=C(C[C@@H]1C(=O)NCCN1S(=O)(=O)c1ccccc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2011.03.115
16221282 92312 0 None 13 2 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 619 9 2 5 5.9 O=C(C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1)N[C@@H]1CCOc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2011.03.115
CHEMBL227713 92312 0 None 13 2 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 619 9 2 5 5.9 O=C(C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1)N[C@@H]1CCOc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2011.03.115
44587181 195456 0 None - 1 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cellsAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells
ChEMBL 588 7 3 6 4.3 CNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2008.07.055
CHEMBL503847 195456 0 None - 1 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cellsAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells
ChEMBL 588 7 3 6 4.3 CNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2008.07.055
16221282 92312 0 None 13 2 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 619 9 2 5 5.9 O=C(C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1)N[C@@H]1CCOc2cc(CN3CCCCC3)ccc21 10.1021/jm070055c
CHEMBL227713 92312 0 None 13 2 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 619 9 2 5 5.9 O=C(C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1)N[C@@H]1CCOc2cc(CN3CCCCC3)ccc21 10.1021/jm070055c
25105469 193840 6 None 2 2 Rat 9.1 pIC50 = 9.1 Functional
Antagonist activity at rat bradykinin B1 receptorAntagonist activity at rat bradykinin B1 receptor
ChEMBL 467 8 3 7 2.6 O=C(CCNC(=O)c1nc2ccccc2n1Cc1ccccc1)Nc1ccc(C2=NCCN2)nc1 10.1016/j.bmcl.2008.08.014
CHEMBL491198 193840 6 None 2 2 Rat 9.1 pIC50 = 9.1 Functional
Antagonist activity at rat bradykinin B1 receptorAntagonist activity at rat bradykinin B1 receptor
ChEMBL 467 8 3 7 2.6 O=C(CCNC(=O)c1nc2ccccc2n1Cc1ccccc1)Nc1ccc(C2=NCCN2)nc1 10.1016/j.bmcl.2008.08.014
60142567 132690 0 None - 1 Human 9.1 pIC50 = 9.1 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 540 5 2 7 3.8 Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)SCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)n1 nan
CHEMBL3648472 132690 0 None - 1 Human 9.1 pIC50 = 9.1 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 540 5 2 7 3.8 Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)SCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)n1 nan
11386138 91216 0 None 8 2 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity at bradykinin B1 receptor expressed in CHO cells assessed as inhibition of des-arg10-kallidin-induced increase in cytosolic calcium level by FLIPR assayAntagonist activity at bradykinin B1 receptor expressed in CHO cells assessed as inhibition of des-arg10-kallidin-induced increase in cytosolic calcium level by FLIPR assay
ChEMBL 482 7 2 6 5.9 COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)Nc2nccc(Cl)c2NC(=O)CC#N)cc1 10.1021/jm049394l
CHEMBL221998 91216 0 None 8 2 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity at bradykinin B1 receptor expressed in CHO cells assessed as inhibition of des-arg10-kallidin-induced increase in cytosolic calcium level by FLIPR assayAntagonist activity at bradykinin B1 receptor expressed in CHO cells assessed as inhibition of des-arg10-kallidin-induced increase in cytosolic calcium level by FLIPR assay
ChEMBL 482 7 2 6 5.9 COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)Nc2nccc(Cl)c2NC(=O)CC#N)cc1 10.1021/jm049394l
44587183 180005 0 None - 1 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cellsAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells
ChEMBL 616 8 3 6 5.0 CC(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2008.07.055
CHEMBL452331 180005 0 None - 1 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cellsAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells
ChEMBL 616 8 3 6 5.0 CC(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2008.07.055
57403391 76869 0 None - 1 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 476 7 2 5 2.2 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@H]2CCN(CC(C)C)CC2(C)C)cc1 10.1016/j.bmcl.2011.11.112
CHEMBL1939934 76869 0 None - 1 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 476 7 2 5 2.2 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@H]2CCN(CC(C)C)CC2(C)C)cc1 10.1016/j.bmcl.2011.11.112
10217706 90000 0 None - 1 Human 9.1 pIC50 = 9.1 Functional
Activity at human bradykinin B1 receptor assessed as inhibition of Des-arg kallidin-induced increase of cytosolic calcium in CHO cells by FLIPRActivity at human bradykinin B1 receptor assessed as inhibition of Des-arg kallidin-induced increase of cytosolic calcium in CHO cells by FLIPR
ChEMBL 494 6 2 5 4.4 Cc1noc(-c2c(F)cccc2-c2ccc([C@@H](C)NC(=O)C3(NC(=O)C(F)(F)F)CC3)c(F)c2)n1 10.1021/jm061094b
CHEMBL218605 90000 0 None - 1 Human 9.1 pIC50 = 9.1 Functional
Activity at human bradykinin B1 receptor assessed as inhibition of Des-arg kallidin-induced increase of cytosolic calcium in CHO cells by FLIPRActivity at human bradykinin B1 receptor assessed as inhibition of Des-arg kallidin-induced increase of cytosolic calcium in CHO cells by FLIPR
ChEMBL 494 6 2 5 4.4 Cc1noc(-c2c(F)cccc2-c2ccc([C@@H](C)NC(=O)C3(NC(=O)C(F)(F)F)CC3)c(F)c2)n1 10.1021/jm061094b
11363856 91310 0 None 13 2 Human 9.0 pIC50 = 9.0 Functional
Antagonist activity at bradykinin B1 receptor expressed in CHO cells assessed as inhibition of des-arg10-kallidin-induced increase in cytosolic calcium level by FLIPR assayAntagonist activity at bradykinin B1 receptor expressed in CHO cells assessed as inhibition of des-arg10-kallidin-induced increase in cytosolic calcium level by FLIPR assay
ChEMBL 490 7 2 7 5.9 Cc1noc(-c2c(F)cccc2-c2ccc([C@@H](C)Nc3nccc(Cl)c3NC(=O)CC#N)cc2)n1 10.1021/jm049394l
CHEMBL222038 91310 0 None 13 2 Human 9.0 pIC50 = 9.0 Functional
Antagonist activity at bradykinin B1 receptor expressed in CHO cells assessed as inhibition of des-arg10-kallidin-induced increase in cytosolic calcium level by FLIPR assayAntagonist activity at bradykinin B1 receptor expressed in CHO cells assessed as inhibition of des-arg10-kallidin-induced increase in cytosolic calcium level by FLIPR assay
ChEMBL 490 7 2 7 5.9 Cc1noc(-c2c(F)cccc2-c2ccc([C@@H](C)Nc3nccc(Cl)c3NC(=O)CC#N)cc2)n1 10.1021/jm049394l
11215488 68955 0 None - 1 Human 9.0 pIC50 = 9.0 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 592 7 2 5 3.8 O=C(CC1C(=O)NCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2011.03.115
CHEMBL1777954 68955 0 None - 1 Human 9.0 pIC50 = 9.0 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 592 7 2 5 3.8 O=C(CC1C(=O)NCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2011.03.115
46230067 206267 0 None - 1 Human 9.0 pIC50 = 9 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 541 5 2 4 4.8 CCN(NC(=O)c1cc(F)cc(C(F)(F)F)c1)C(=O)N[C@H](C)c1ncc(C(=O)N2[C@@H](C)CC[C@H]2C)cc1F 10.1016/j.bmcl.2009.11.119
CHEMBL591742 206267 0 None - 1 Human 9.0 pIC50 = 9 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 541 5 2 4 4.8 CCN(NC(=O)c1cc(F)cc(C(F)(F)F)c1)C(=O)N[C@H](C)c1ncc(C(=O)N2[C@@H](C)CC[C@H]2C)cc1F 10.1016/j.bmcl.2009.11.119
46230939 207061 0 None - 1 Human 9.0 pIC50 = 9 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 437 5 2 7 3.2 CC(C)N(O)C(=O)NCc1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F 10.1016/j.bmcl.2009.11.121
CHEMBL597235 207061 0 None - 1 Human 9.0 pIC50 = 9 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 437 5 2 7 3.2 CC(C)N(O)C(=O)NCc1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F 10.1016/j.bmcl.2009.11.121
46216846 208008 0 None - 1 Human 9.0 pIC50 = 9 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilization
ChEMBL 543 8 2 11 4.9 COc1cc(C(=O)Nc2nonc2NCc2ccc(-c3cc(Cl)cc(F)c3-c3noc(C)n3)cc2F)on1 10.1016/j.bmcl.2009.11.120
CHEMBL603668 208008 0 None - 1 Human 9.0 pIC50 = 9 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilization
ChEMBL 543 8 2 11 4.9 COc1cc(C(=O)Nc2nonc2NCc2ccc(-c3cc(Cl)cc(F)c3-c3noc(C)n3)cc2F)on1 10.1016/j.bmcl.2009.11.120
56594642 72497 0 None 21 2 Human 9.0 pIC50 = 9 Functional
Antagonist activity at human B1 receptor expressed in CHO cells by aequorin-based calcium flux assayAntagonist activity at human B1 receptor expressed in CHO cells by aequorin-based calcium flux assay
ChEMBL 540 5 1 5 6.1 Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2c(Cl)cccc12 10.1021/jm200808v
CHEMBL1834616 72497 0 None 21 2 Human 9.0 pIC50 = 9 Functional
Antagonist activity at human B1 receptor expressed in CHO cells by aequorin-based calcium flux assayAntagonist activity at human B1 receptor expressed in CHO cells by aequorin-based calcium flux assay
ChEMBL 540 5 1 5 6.1 Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2c(Cl)cccc12 10.1021/jm200808v
44587182 195469 0 None - 1 Human 9.0 pIC50 = 9 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cellsAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells
ChEMBL 602 7 2 6 4.6 CN(C)Cc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2008.07.055
CHEMBL504119 195469 0 None - 1 Human 9.0 pIC50 = 9 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cellsAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells
ChEMBL 602 7 2 6 4.6 CN(C)Cc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2008.07.055
57394684 76871 0 None - 1 Human 9.0 pIC50 = 9.0 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 510 7 2 5 2.8 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@H]2CCN(Cc3ccccc3)CC2(C)C)cc1 10.1016/j.bmcl.2011.11.112
CHEMBL1939936 76871 0 None - 1 Human 9.0 pIC50 = 9.0 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 510 7 2 5 2.8 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@H]2CCN(Cc3ccccc3)CC2(C)C)cc1 10.1016/j.bmcl.2011.11.112
56594772 72555 0 None 15 2 Human 9.0 pIC50 = 9.0 Functional
Antagonist activity at human B1 receptor expressed in CHO cells by aequorin-based calcium flux assayAntagonist activity at human B1 receptor expressed in CHO cells by aequorin-based calcium flux assay
ChEMBL 542 5 1 6 5.6 Cc1nn(-c2ccc(C(=O)N[C@@H]3CCOc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2c(Cl)cccc12 10.1021/jm200808v
CHEMBL1834750 72555 0 None 15 2 Human 9.0 pIC50 = 9.0 Functional
Antagonist activity at human B1 receptor expressed in CHO cells by aequorin-based calcium flux assayAntagonist activity at human B1 receptor expressed in CHO cells by aequorin-based calcium flux assay
ChEMBL 542 5 1 6 5.6 Cc1nn(-c2ccc(C(=O)N[C@@H]3CCOc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2c(Cl)cccc12 10.1021/jm200808v
56594769 72500 0 None -6 2 Rabbit 9.0 pIC50 = 9.0 Functional
Inhibition of rabbit B1 receptor by cellular calcium flux assayInhibition of rabbit B1 receptor by cellular calcium flux assay
ChEMBL 541 5 1 6 5.5 Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cn2)c(=O)c2c(Cl)cccc12 10.1021/jm200808v
CHEMBL1834619 72500 0 None -6 2 Rabbit 9.0 pIC50 = 9.0 Functional
Inhibition of rabbit B1 receptor by cellular calcium flux assayInhibition of rabbit B1 receptor by cellular calcium flux assay
ChEMBL 541 5 1 6 5.5 Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cn2)c(=O)c2c(Cl)cccc12 10.1021/jm200808v
57394685 76872 0 None - 1 Human 9.0 pIC50 = 9.0 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 460 6 2 5 1.7 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@H]2CCN(C3CC3)CC2(C)C)cc1 10.1016/j.bmcl.2011.11.112
CHEMBL1939937 76872 0 None - 1 Human 9.0 pIC50 = 9.0 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 460 6 2 5 1.7 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@H]2CCN(C3CC3)CC2(C)C)cc1 10.1016/j.bmcl.2011.11.112
44430696 94727 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity in human bradykinin B1 receptor by FLIPR methodAntagonist activity in human bradykinin B1 receptor by FLIPR method
ChEMBL 484 6 2 4 6.1 N#CC1(c2ccccc2C(F)(F)F)CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1 10.1016/j.bmcl.2007.03.059
CHEMBL234096 94727 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity in human bradykinin B1 receptor by FLIPR methodAntagonist activity in human bradykinin B1 receptor by FLIPR method
ChEMBL 484 6 2 4 6.1 N#CC1(c2ccccc2C(F)(F)F)CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1 10.1016/j.bmcl.2007.03.059
11225601 148805 0 None 3 2 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at bradykinin B1 receptor expressed in CHO cells assessed as inhibition of des-arg10-kallidin-induced increase in cytosolic calcium level by FLIPR assayAntagonist activity at bradykinin B1 receptor expressed in CHO cells assessed as inhibition of des-arg10-kallidin-induced increase in cytosolic calcium level by FLIPR assay
ChEMBL 490 7 2 8 4.8 C[C@@H](Nc1nccc(Cl)c1NC(=O)CC#N)c1ccc(-c2cccc(F)c2-c2nnn(C)n2)cc1 10.1021/jm049394l
CHEMBL387638 148805 0 None 3 2 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at bradykinin B1 receptor expressed in CHO cells assessed as inhibition of des-arg10-kallidin-induced increase in cytosolic calcium level by FLIPR assayAntagonist activity at bradykinin B1 receptor expressed in CHO cells assessed as inhibition of des-arg10-kallidin-induced increase in cytosolic calcium level by FLIPR assay
ChEMBL 490 7 2 8 4.8 C[C@@H](Nc1nccc(Cl)c1NC(=O)CC#N)c1ccc(-c2cccc(F)c2-c2nnn(C)n2)cc1 10.1021/jm049394l
46230833 206042 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 423 4 2 6 4.1 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)N(C)O)c(F)c2)no1 10.1016/j.bmcl.2009.11.121
CHEMBL590150 206042 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 423 4 2 6 4.1 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)N(C)O)c(F)c2)no1 10.1016/j.bmcl.2009.11.121
54580628 68945 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 592 7 2 5 4.1 O=C(CC1C(=O)NCCN1S(=O)(=O)c1ccc(Cl)c(Cl)c1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2011.03.115
CHEMBL1777879 68945 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 592 7 2 5 4.1 O=C(CC1C(=O)NCCN1S(=O)(=O)c1ccc(Cl)c(Cl)c1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2011.03.115
11272685 68972 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 540 7 2 6 1.9 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCOCC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
CHEMBL1777971 68972 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 540 7 2 6 1.9 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCOCC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
44587041 194656 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cellsAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells
ChEMBL 574 6 3 6 4.0 NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2008.07.055
CHEMBL496459 194656 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cellsAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells
ChEMBL 574 6 3 6 4.0 NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2008.07.055
54585540 68977 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 526 7 3 5 3.0 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC(C)(C)C)ccc32)cc1 10.1016/j.bmcl.2011.03.115
CHEMBL1777976 68977 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 526 7 3 5 3.0 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC(C)(C)C)ccc32)cc1 10.1016/j.bmcl.2011.03.115
46229967 206319 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 537 6 2 3 5.1 C[C@H]1CC[C@@H](C)N1C(=O)c1ccc([C@@H](C)NC(=O)C2(NC(=O)c3cc(F)cc(C(F)(F)F)c3)CC2)c(F)c1 10.1016/j.bmcl.2009.11.119
CHEMBL592239 206319 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 537 6 2 3 5.1 C[C@H]1CC[C@@H](C)N1C(=O)c1ccc([C@@H](C)NC(=O)C2(NC(=O)c3cc(F)cc(C(F)(F)F)c3)CC2)c(F)c1 10.1016/j.bmcl.2009.11.119
46230162 208096 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 548 5 2 6 5.2 CCN(NC(=O)C(F)(F)F)C(=O)N[C@H](C)c1ncc(-c2cc(Cl)cc(Cl)c2-c2noc(C)n2)cc1F 10.1016/j.bmcl.2009.11.119
CHEMBL604177 208096 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 548 5 2 6 5.2 CCN(NC(=O)C(F)(F)F)C(=O)N[C@H](C)c1ncc(-c2cc(Cl)cc(Cl)c2-c2noc(C)n2)cc1F 10.1016/j.bmcl.2009.11.119
46911683 22006 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium flux
ChEMBL 629 10 2 4 6.6 C=C(CN1CCCC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1 10.1016/j.bmcl.2010.06.010
CHEMBL1210756 22006 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium flux
ChEMBL 629 10 2 4 6.6 C=C(CN1CCCC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1 10.1016/j.bmcl.2010.06.010
57403390 76856 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 489 5 2 6 1.4 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCS(=O)(=O)c3ccccc32)cc1 10.1016/j.bmcl.2011.11.112
CHEMBL1939921 76856 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 489 5 2 6 1.4 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCS(=O)(=O)c3ccccc32)cc1 10.1016/j.bmcl.2011.11.112
57394683 76870 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 490 6 2 5 2.6 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@H]2CCN(CC(C)(C)C)CC2(C)C)cc1 10.1016/j.bmcl.2011.11.112
CHEMBL1939935 76870 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 490 6 2 5 2.6 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@H]2CCN(CC(C)(C)C)CC2(C)C)cc1 10.1016/j.bmcl.2011.11.112
44421279 91931 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at bradykinin B1 receptor expressed in CHO cells assessed as inhibition of des-arg10-kallidin-induced increase in cytosolic calcium level by FLIPR assayAntagonist activity at bradykinin B1 receptor expressed in CHO cells assessed as inhibition of des-arg10-kallidin-induced increase in cytosolic calcium level by FLIPR assay
ChEMBL 442 7 2 6 5.2 COC(=O)c1ccc(C)cc1-c1ccc([C@@H](C)Nc2nccc(C)c2NC(=O)CC#N)cc1 10.1021/jm049394l
CHEMBL225133 91931 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at bradykinin B1 receptor expressed in CHO cells assessed as inhibition of des-arg10-kallidin-induced increase in cytosolic calcium level by FLIPR assayAntagonist activity at bradykinin B1 receptor expressed in CHO cells assessed as inhibition of des-arg10-kallidin-induced increase in cytosolic calcium level by FLIPR assay
ChEMBL 442 7 2 6 5.2 COC(=O)c1ccc(C)cc1-c1ccc([C@@H](C)Nc2nccc(C)c2NC(=O)CC#N)cc1 10.1021/jm049394l
46230940 207062 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 451 4 2 7 3.6 Cn1nnc(-c2c(F)cc(Cl)cc2-c2cnc(CNC(=O)N(O)C(C)(C)C)c(F)c2)n1 10.1016/j.bmcl.2009.11.121
CHEMBL597236 207062 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 451 4 2 7 3.6 Cn1nnc(-c2c(F)cc(Cl)cc2-c2cnc(CNC(=O)N(O)C(C)(C)C)c(F)c2)n1 10.1016/j.bmcl.2009.11.121
44587184 176933 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cellsAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells
ChEMBL 630 9 3 6 5.3 CC(C)CNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2008.07.055
CHEMBL444431 176933 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cellsAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells
ChEMBL 630 9 3 6 5.3 CC(C)CNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2008.07.055
11284304 68973 0 None - 1 Human 8.8 pIC50 = 8.8 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 553 7 2 6 1.8 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCN(C)CC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
CHEMBL1777972 68973 0 None - 1 Human 8.8 pIC50 = 8.8 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 553 7 2 6 1.8 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCN(C)CC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
57401663 76855 0 None - 1 Human 8.8 pIC50 = 8.8 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 455 5 3 5 2.0 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCC(O)c3ccccc32)cc1 10.1016/j.bmcl.2011.11.112
CHEMBL1939920 76855 0 None - 1 Human 8.8 pIC50 = 8.8 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 455 5 3 5 2.0 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCC(O)c3ccccc32)cc1 10.1016/j.bmcl.2011.11.112
11167607 144123 0 None - 1 Human 8.8 pIC50 = 8.8 Functional
Antagonist activity at bradykinin B1 receptor expressed in CHO cells assessed as inhibition of des-arg10-kallidin-induced increase in cytosolic calcium level by FLIPR assayAntagonist activity at bradykinin B1 receptor expressed in CHO cells assessed as inhibition of des-arg10-kallidin-induced increase in cytosolic calcium level by FLIPR assay
ChEMBL 482 7 2 6 5.9 COC(=O)c1ccc(Cl)cc1-c1ccc([C@@H](C)Nc2nccc(Cl)c2NC(=O)CC#N)cc1 10.1021/jm049394l
CHEMBL375288 144123 0 None - 1 Human 8.8 pIC50 = 8.8 Functional
Antagonist activity at bradykinin B1 receptor expressed in CHO cells assessed as inhibition of des-arg10-kallidin-induced increase in cytosolic calcium level by FLIPR assayAntagonist activity at bradykinin B1 receptor expressed in CHO cells assessed as inhibition of des-arg10-kallidin-induced increase in cytosolic calcium level by FLIPR assay
ChEMBL 482 7 2 6 5.9 COC(=O)c1ccc(Cl)cc1-c1ccc([C@@H](C)Nc2nccc(Cl)c2NC(=O)CC#N)cc1 10.1021/jm049394l
46216844 207450 0 None - 1 Human 8.8 pIC50 = 8.8 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 546 7 2 4 5.5 CCN(NC(=O)C(F)(F)F)C(=O)N[C@H](C)c1ncc(-c2cc(Cl)cc(Cl)c2OCC(F)F)cc1F 10.1016/j.bmcl.2009.11.119
CHEMBL599779 207450 0 None - 1 Human 8.8 pIC50 = 8.8 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 546 7 2 4 5.5 CCN(NC(=O)C(F)(F)F)C(=O)N[C@H](C)c1ncc(-c2cc(Cl)cc(Cl)c2OCC(F)F)cc1F 10.1016/j.bmcl.2009.11.119
16102897 94014 17 None - 1 Human 8.8 pIC50 = 8.8 Functional
Activity at human bradykinin B1 receptor assessed as inhibition of Des-arg kallidin-induced increase of cytosolic calcium in CHO cells by FLIPRActivity at human bradykinin B1 receptor assessed as inhibition of Des-arg kallidin-induced increase of cytosolic calcium in CHO cells by FLIPR
ChEMBL 486 6 2 4 4.3 COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1021/jm061094b
CHEMBL232943 94014 17 None - 1 Human 8.8 pIC50 = 8.8 Functional
Activity at human bradykinin B1 receptor assessed as inhibition of Des-arg kallidin-induced increase of cytosolic calcium in CHO cells by FLIPRActivity at human bradykinin B1 receptor assessed as inhibition of Des-arg kallidin-induced increase of cytosolic calcium in CHO cells by FLIPR
ChEMBL 486 6 2 4 4.3 COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1021/jm061094b
17751347 76888 0 None - 1 Human 8.8 pIC50 = 8.8 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 480 4 1 5 1.9 Cc1cc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N2CCC3(CCN(C)C3)C2)c(C)cc1Cl 10.1016/j.bmcl.2011.11.112
CHEMBL1939953 76888 0 None - 1 Human 8.8 pIC50 = 8.8 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 480 4 1 5 1.9 Cc1cc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N2CCC3(CCN(C)C3)C2)c(C)cc1Cl 10.1016/j.bmcl.2011.11.112
46230403 207115 0 None - 1 Human 8.8 pIC50 = 8.8 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilization
ChEMBL 458 6 2 7 4.5 CC(=O)Nn1ccnc1NCc1ccc(-c2cc(Cl)cc(F)c2-c2noc(C)n2)cc1F 10.1016/j.bmcl.2009.11.120
CHEMBL597546 207115 0 None - 1 Human 8.8 pIC50 = 8.8 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilization
ChEMBL 458 6 2 7 4.5 CC(=O)Nn1ccnc1NCc1ccc(-c2cc(Cl)cc(F)c2-c2noc(C)n2)cc1F 10.1016/j.bmcl.2009.11.120
46230459 205999 0 None - 1 Human 8.8 pIC50 = 8.8 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilization
ChEMBL 476 6 2 8 5.1 CC(=O)Nc1nsnc1NCc1ccc(-c2cc(Cl)cc(F)c2-c2noc(C)n2)cc1F 10.1016/j.bmcl.2009.11.120
CHEMBL589900 205999 0 None - 1 Human 8.8 pIC50 = 8.8 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilization
ChEMBL 476 6 2 8 5.1 CC(=O)Nc1nsnc1NCc1ccc(-c2cc(Cl)cc(F)c2-c2noc(C)n2)cc1F 10.1016/j.bmcl.2009.11.120
46230352 207193 0 None - 1 Human 8.8 pIC50 = 8.8 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilization
ChEMBL 541 8 2 10 4.8 COc1cc(C(=O)Nn2ccnc2NCc2ccc(-c3cc(Cl)cc(F)c3-c3noc(C)n3)cc2F)on1 10.1016/j.bmcl.2009.11.120
CHEMBL598147 207193 0 None - 1 Human 8.8 pIC50 = 8.8 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilization
ChEMBL 541 8 2 10 4.8 COc1cc(C(=O)Nn2ccnc2NCc2ccc(-c3cc(Cl)cc(F)c3-c3noc(C)n3)cc2F)on1 10.1016/j.bmcl.2009.11.120
44587185 195717 0 None - 1 Human 8.8 pIC50 = 8.8 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cellsAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells
ChEMBL 630 7 3 6 5.4 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2008.07.055
CHEMBL508043 195717 0 None - 1 Human 8.8 pIC50 = 8.8 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cellsAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells
ChEMBL 630 7 3 6 5.4 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2008.07.055
11342350 68953 0 None - 1 Human 8.8 pIC50 = 8.8 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 592 7 2 5 3.8 O=C(CC1C(=O)NCCN1S(=O)(=O)c1ccc(C(F)(F)F)cc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2011.03.115
CHEMBL1777887 68953 0 None - 1 Human 8.8 pIC50 = 8.8 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 592 7 2 5 3.8 O=C(CC1C(=O)NCCN1S(=O)(=O)c1ccc(C(F)(F)F)cc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2011.03.115
46216845 207452 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 530 7 2 4 5.0 CCN(NC(=O)C(F)(F)F)C(=O)N[C@H](C)c1ncc(-c2cc(Cl)cc(F)c2OCC(F)F)cc1F 10.1016/j.bmcl.2009.11.119
CHEMBL599780 207452 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 530 7 2 4 5.0 CCN(NC(=O)C(F)(F)F)C(=O)N[C@H](C)c1ncc(-c2cc(Cl)cc(F)c2OCC(F)F)cc1F 10.1016/j.bmcl.2009.11.119
23630715 159432 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 550 7 3 5 4.0 CN1CCC(N2CCC(CCNC(=O)c3n[nH]c(NC(=O)c4ccccc4Cl)c3Br)CC2)CC1 10.1021/jm051292n
CHEMBL397248 159432 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 550 7 3 5 4.0 CN1CCC(N2CCC(CCNC(=O)c3n[nH]c(NC(=O)c4ccccc4Cl)c3Br)CC2)CC1 10.1021/jm051292n
10151875 143757 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Activity at human bradykinin B1 receptor assessed as inhibition of Des-arg kallidin-induced increase of cytosolic calcium in CHO cells by FLIPRActivity at human bradykinin B1 receptor assessed as inhibition of Des-arg kallidin-induced increase of cytosolic calcium in CHO cells by FLIPR
ChEMBL 470 6 2 4 3.8 COC(=O)c1c(F)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1021/jm061094b
CHEMBL374580 143757 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Activity at human bradykinin B1 receptor assessed as inhibition of Des-arg kallidin-induced increase of cytosolic calcium in CHO cells by FLIPRActivity at human bradykinin B1 receptor assessed as inhibition of Des-arg kallidin-induced increase of cytosolic calcium in CHO cells by FLIPR
ChEMBL 470 6 2 4 3.8 COC(=O)c1c(F)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1021/jm061094b
10031511 23718 0 None 1 2 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at human bradykinin B1 receptor in human MR5 cells assessed as [3H]inositol phosphate accumulationAntagonist activity at human bradykinin B1 receptor in human MR5 cells assessed as [3H]inositol phosphate accumulation
ChEMBL 601 9 2 6 5.7 CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCN(c4ccncc4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 10.1021/jm1000776
CHEMBL1253497 23718 0 None 1 2 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at human bradykinin B1 receptor in human MR5 cells assessed as [3H]inositol phosphate accumulationAntagonist activity at human bradykinin B1 receptor in human MR5 cells assessed as [3H]inositol phosphate accumulation
ChEMBL 601 9 2 6 5.7 CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCN(c4ccncc4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 10.1021/jm1000776
23630813 158589 0 None - 1 Human 8.0 pIC50 = 8 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 560 5 4 5 4.1 O=C(Nc1[nH]nc(C(=O)NC2N=C(c3ccccc3)c3ccccc3NC2=O)c1Br)c1ccccc1F 10.1021/jm051292n
CHEMBL396524 158589 0 None - 1 Human 8.0 pIC50 = 8 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 560 5 4 5 4.1 O=C(Nc1[nH]nc(C(=O)NC2N=C(c3ccccc3)c3ccccc3NC2=O)c1Br)c1ccccc1F 10.1021/jm051292n
16221282 92312 0 None -13 2 Rabbit 8.0 pIC50 = 8.0 Functional
Antagonist activity at rabbit bradykinin B1 receptorAntagonist activity at rabbit bradykinin B1 receptor
ChEMBL 619 9 2 5 5.9 O=C(C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1)N[C@@H]1CCOc2cc(CN3CCCCC3)ccc21 10.1021/jm070055c
CHEMBL227713 92312 0 None -13 2 Rabbit 8.0 pIC50 = 8.0 Functional
Antagonist activity at rabbit bradykinin B1 receptorAntagonist activity at rabbit bradykinin B1 receptor
ChEMBL 619 9 2 5 5.9 O=C(C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1)N[C@@H]1CCOc2cc(CN3CCCCC3)ccc21 10.1021/jm070055c
16221111 92314 0 None - 1 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 571 11 3 5 5.6 CC(C)CNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 10.1021/jm070055c
CHEMBL227721 92314 0 None - 1 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 571 11 3 5 5.6 CC(C)CNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 10.1021/jm070055c
11215913 143317 0 None - 1 Human 8.0 pIC50 = 8.0 Functional
Antagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilizationAntagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilization
ChEMBL 646 9 2 6 4.9 CN1c2cc(CN3CCCCC3)ccc2[C@@H](NC(=O)C[C@@H](NS(=O)(=O)c2ccc3ccccc3c2)c2ccccc2)CS1(=O)=O 10.1021/jm061224g
CHEMBL373654 143317 0 None - 1 Human 8.0 pIC50 = 8.0 Functional
Antagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilizationAntagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilization
ChEMBL 646 9 2 6 4.9 CN1c2cc(CN3CCCCC3)ccc2[C@@H](NC(=O)C[C@@H](NS(=O)(=O)c2ccc3ccccc3c2)c2ccccc2)CS1(=O)=O 10.1021/jm061224g
16220918 168249 0 None - 1 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 585 9 2 6 4.7 O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCOc2cc(CN3CCOCC3)ccc21 10.1021/jm070055c
CHEMBL412762 168249 0 None - 1 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 585 9 2 6 4.7 O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCOc2cc(CN3CCOCC3)ccc21 10.1021/jm070055c
44579766 200026 0 None - 1 Crab-eating macaque 6.0 pIC50 = 6.0 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 423 6 1 5 3.7 CN(Cc1ccc(C2=NCCN2)cc1)C(=O)c1nc2ccccc2n1Cc1ccccc1 10.1016/j.bmcl.2008.08.014
CHEMBL523773 200026 0 None - 1 Crab-eating macaque 6.0 pIC50 = 6.0 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 423 6 1 5 3.7 CN(Cc1ccc(C2=NCCN2)cc1)C(=O)c1nc2ccccc2n1Cc1ccccc1 10.1016/j.bmcl.2008.08.014
49863234 22001 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium flux
ChEMBL 611 12 3 4 6.3 C=C(CNCC1CC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2010.06.010
CHEMBL1210751 22001 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium flux
ChEMBL 611 12 3 4 6.3 C=C(CNCC1CC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2010.06.010
44561641 193503 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assay
ChEMBL 520 8 2 5 4.5 O=C(C[C@@H](O)CS(=O)(=O)c1ccc2ccccc2c1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2008.07.108
CHEMBL488677 193503 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assay
ChEMBL 520 8 2 5 4.5 O=C(C[C@@H](O)CS(=O)(=O)c1ccc2ccccc2c1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2008.07.108
11635365 181340 0 None -2 2 Rabbit 8.0 pIC50 = 8.0 Functional
Antagonist activity at rabbit bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assayAntagonist activity at rabbit bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assay
ChEMBL 554 8 3 6 3.4 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2008.07.108
CHEMBL455642 181340 0 None -2 2 Rabbit 8.0 pIC50 = 8.0 Functional
Antagonist activity at rabbit bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assayAntagonist activity at rabbit bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assay
ChEMBL 554 8 3 6 3.4 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2008.07.108
11635365 181340 0 None -2 2 Rabbit 8.0 pIC50 = 8.0 Functional
Inhibition of rabbit B1 receptor by cellular calcium flux assayInhibition of rabbit B1 receptor by cellular calcium flux assay
ChEMBL 554 8 3 6 3.4 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1cccc(C(F)(F)F)c1 10.1021/jm200808v
CHEMBL455642 181340 0 None -2 2 Rabbit 8.0 pIC50 = 8.0 Functional
Inhibition of rabbit B1 receptor by cellular calcium flux assayInhibition of rabbit B1 receptor by cellular calcium flux assay
ChEMBL 554 8 3 6 3.4 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1cccc(C(F)(F)F)c1 10.1021/jm200808v
11214998 83330 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Inhibition of human B1 receptor by calcium influx functional assayInhibition of human B1 receptor by calcium influx functional assay
ChEMBL 551 8 2 4 5.3 CC(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2006.01.069
CHEMBL206247 83330 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Inhibition of human B1 receptor by calcium influx functional assayInhibition of human B1 receptor by calcium influx functional assay
ChEMBL 551 8 2 4 5.3 CC(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2006.01.069
44428100 160323 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 396 3 2 4 4.5 Cc1nc(-c2n[nH]c(NC(=O)c3ccccc3Cl)c2Br)cs1 10.1021/jm051292n
CHEMBL398008 160323 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 396 3 2 4 4.5 Cc1nc(-c2n[nH]c(NC(=O)c3ccccc3Cl)c2Br)cs1 10.1021/jm051292n
56594241 72651 0 None 4 2 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human B1 bradykinin receptor expressed in CHO cells by aqueorin-based calcium flux assayAntagonist activity at human B1 bradykinin receptor expressed in CHO cells by aqueorin-based calcium flux assay
ChEMBL 492 5 1 4 6.3 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3ccccc3c2=O)c1 10.1016/j.bmcl.2011.10.068
CHEMBL1835756 72651 0 None 4 2 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human B1 bradykinin receptor expressed in CHO cells by aqueorin-based calcium flux assayAntagonist activity at human B1 bradykinin receptor expressed in CHO cells by aqueorin-based calcium flux assay
ChEMBL 492 5 1 4 6.3 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3ccccc3c2=O)c1 10.1016/j.bmcl.2011.10.068
16220987 85887 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 555 9 3 5 5.3 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(Cl)c1)c1ccccc1 10.1021/jm070055c
CHEMBL2113274 85887 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 555 9 3 5 5.3 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(Cl)c1)c1ccccc1 10.1021/jm070055c
54587551 68962 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 538 7 2 5 3.1 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@@H]2CC(=O)N[C@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
CHEMBL1777961 68962 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 538 7 2 5 3.1 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@@H]2CC(=O)N[C@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
44580012 193825 0 None - 1 Crab-eating macaque 5.9 pIC50 = 5.9 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 495 8 1 6 4.6 CN(Cc1ccc(-c2nccs2)cc1)C(=O)CNC(=O)c1nc2ccccc2n1Cc1ccccc1 10.1016/j.bmcl.2008.08.014
CHEMBL491041 193825 0 None - 1 Crab-eating macaque 5.9 pIC50 = 5.9 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 495 8 1 6 4.6 CN(Cc1ccc(-c2nccs2)cc1)C(=O)CNC(=O)c1nc2ccccc2n1Cc1ccccc1 10.1016/j.bmcl.2008.08.014
24946441 193913 0 None - 1 Crab-eating macaque 5.9 pIC50 = 5.9 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 468 6 0 6 2.9 CN(CC(=O)N1CCN(c2ccncc2)CC1)C(=O)c1nc2ccccc2n1Cc1ccccc1 10.1016/j.bmcl.2008.08.014
CHEMBL491829 193913 0 None - 1 Crab-eating macaque 5.9 pIC50 = 5.9 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 468 6 0 6 2.9 CN(CC(=O)N1CCN(c2ccncc2)CC1)C(=O)c1nc2ccccc2n1Cc1ccccc1 10.1016/j.bmcl.2008.08.014
60142169 132678 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 494 5 2 4 4.5 COC(=O)c1c(Cl)cccc1-c1ccc2c(c1)CCCC2NC(=O)C1(NC(=O)C(F)(F)F)CC1 nan
CHEMBL3648460 132678 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 494 5 2 4 4.5 COC(=O)c1c(Cl)cccc1-c1ccc2c(c1)CCCC2NC(=O)C1(NC(=O)C(F)(F)F)CC1 nan
56835163 76343 0 None 1 2 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human B1 bradykinin receptor expressed in CHO cells by aqueorin-based calcium flux assayAntagonist activity at human B1 bradykinin receptor expressed in CHO cells by aqueorin-based calcium flux assay
ChEMBL 510 5 1 4 6.4 O=C(N[C@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3cccc(F)c3c2=O)cc1 10.1016/j.bmcl.2011.10.068
CHEMBL1934264 76343 0 None 1 2 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human B1 bradykinin receptor expressed in CHO cells by aqueorin-based calcium flux assayAntagonist activity at human B1 bradykinin receptor expressed in CHO cells by aqueorin-based calcium flux assay
ChEMBL 510 5 1 4 6.4 O=C(N[C@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3cccc(F)c3c2=O)cc1 10.1016/j.bmcl.2011.10.068
23630613 98858 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 607 8 2 7 5.4 O=C(Nc1c(Br)c(C(=O)NCCC2CCN(c3ccncc3)CC2)nn1-c1ccccn1)c1ccccc1Cl 10.1021/jm051292n
CHEMBL241937 98858 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 607 8 2 7 5.4 O=C(Nc1c(Br)c(C(=O)NCCC2CCN(c3ccncc3)CC2)nn1-c1ccccn1)c1ccccc1Cl 10.1021/jm051292n
11363856 91310 0 None -13 2 Rabbit 7.9 pIC50 = 7.9 Functional
Activity at rabbit bradykinin B1 receptor assessed by FLIPR assayActivity at rabbit bradykinin B1 receptor assessed by FLIPR assay
ChEMBL 490 7 2 7 5.9 Cc1noc(-c2c(F)cccc2-c2ccc([C@@H](C)Nc3nccc(Cl)c3NC(=O)CC#N)cc2)n1 10.1021/jm049394l
CHEMBL222038 91310 0 None -13 2 Rabbit 7.9 pIC50 = 7.9 Functional
Activity at rabbit bradykinin B1 receptor assessed by FLIPR assayActivity at rabbit bradykinin B1 receptor assessed by FLIPR assay
ChEMBL 490 7 2 7 5.9 Cc1noc(-c2c(F)cccc2-c2ccc([C@@H](C)Nc3nccc(Cl)c3NC(=O)CC#N)cc2)n1 10.1021/jm049394l
23630920 99724 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 636 9 2 7 6.0 COc1ccc(-n2nc(C(=O)NCCC3CCN(c4ccncc4)CC3)c(Br)c2NC(=O)c2ccccc2Cl)cc1 10.1021/jm051292n
CHEMBL244093 99724 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 636 9 2 7 6.0 COc1ccc(-n2nc(C(=O)NCCC3CCN(c4ccncc4)CC3)c(Br)c2NC(=O)c2ccccc2Cl)cc1 10.1021/jm051292n
17751599 76865 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 420 5 3 5 0.9 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCNCC2(C)C)cc1 10.1016/j.bmcl.2011.11.112
CHEMBL1939930 76865 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 420 5 3 5 0.9 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCNCC2(C)C)cc1 10.1016/j.bmcl.2011.11.112
57401425 76338 0 None -1 2 Rabbit 6.9 pIC50 = 6.9 Functional
Antagonist activity at rabbit B1 bradykinin receptor expressed in CHO cellsAntagonist activity at rabbit B1 bradykinin receptor expressed in CHO cells
ChEMBL 492 5 1 4 6.3 O=C(N[C@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3ccccc3c2=O)cc1 10.1016/j.bmcl.2011.10.068
CHEMBL1934259 76338 0 None -1 2 Rabbit 6.9 pIC50 = 6.9 Functional
Antagonist activity at rabbit B1 bradykinin receptor expressed in CHO cellsAntagonist activity at rabbit B1 bradykinin receptor expressed in CHO cells
ChEMBL 492 5 1 4 6.3 O=C(N[C@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3ccccc3c2=O)cc1 10.1016/j.bmcl.2011.10.068
25207727 206217 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 435 6 2 5 2.6 CC1CCC(C)N1C(=O)c1ccc([C@@H](C)NC(=O)C2(NC(=O)c3cncnc3)CC2)cc1 10.1016/j.bmcl.2009.11.119
CHEMBL591354 206217 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 435 6 2 5 2.6 CC1CCC(C)N1C(=O)c1ccc([C@@H](C)NC(=O)C2(NC(=O)c3cncnc3)CC2)cc1 10.1016/j.bmcl.2009.11.119
16221054 148850 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 591 9 3 5 5.6 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cc(Cl)c(F)cc1F)c1ccccc1 10.1021/jm070055c
CHEMBL387982 148850 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 591 9 3 5 5.6 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cc(Cl)c(F)cc1F)c1ccccc1 10.1021/jm070055c
11284458 147366 2 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 565 7 2 4 5.7 CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2011.03.115
CHEMBL381366 147366 2 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 565 7 2 4 5.7 CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2011.03.115
11284458 147366 2 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cellsAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells
ChEMBL 565 7 2 4 5.7 CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2008.07.055
CHEMBL381366 147366 2 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cellsAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells
ChEMBL 565 7 2 4 5.7 CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2008.07.055
23631903 99564 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 531 6 4 6 3.7 Nc1cccc(N2CCC(CNC(=O)c3n[nH]c(NC(=O)c4ccccc4Cl)c3Br)CC2)n1 10.1021/jm051292n
CHEMBL243680 99564 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 531 6 4 6 3.7 Nc1cccc(N2CCC(CNC(=O)c3n[nH]c(NC(=O)c4ccccc4Cl)c3Br)CC2)n1 10.1021/jm051292n
11284458 147366 2 None - 1 Human 7.9 pIC50 = 7.9 Functional
Inhibition of human B1 receptor by calcium influx functional assayInhibition of human B1 receptor by calcium influx functional assay
ChEMBL 565 7 2 4 5.7 CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2006.01.069
CHEMBL381366 147366 2 None - 1 Human 7.9 pIC50 = 7.9 Functional
Inhibition of human B1 receptor by calcium influx functional assayInhibition of human B1 receptor by calcium influx functional assay
ChEMBL 565 7 2 4 5.7 CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2006.01.069
44561786 179442 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assay
ChEMBL 580 9 1 4 7.0 O=C(CC(CS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2008.07.108
CHEMBL449789 179442 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assay
ChEMBL 580 9 1 4 7.0 O=C(CC(CS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2008.07.108
17751422 76881 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 460 5 1 5 1.5 CN(C)[C@@H]1CCN(C(=O)C[C@@H]2C(=O)NC=CN2S(=O)(=O)c2cccc(Cl)c2Cl)C1 10.1016/j.bmcl.2011.11.112
CHEMBL1939946 76881 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 460 5 1 5 1.5 CN(C)[C@@H]1CCN(C(=O)C[C@@H]2C(=O)NC=CN2S(=O)(=O)c2cccc(Cl)c2Cl)C1 10.1016/j.bmcl.2011.11.112
11420875 84112 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Inhibition of human B1 receptor by calcium influx functional assayInhibition of human B1 receptor by calcium influx functional assay
ChEMBL 511 7 2 4 5.0 Cc1ccc(S(=O)(=O)N2CCCC[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC(C)(C)C)ccc32)cc1 10.1016/j.bmcl.2006.01.069
CHEMBL208387 84112 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Inhibition of human B1 receptor by calcium influx functional assayInhibition of human B1 receptor by calcium influx functional assay
ChEMBL 511 7 2 4 5.0 Cc1ccc(S(=O)(=O)N2CCCC[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC(C)(C)C)ccc32)cc1 10.1016/j.bmcl.2006.01.069
44579811 193646 0 None - 1 Crab-eating macaque 5.9 pIC50 = 5.9 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 502 7 1 6 2.8 CCC(NC(=O)c1nc2ccccc2n1Cc1ccccc1)C(=O)N1CCN(C2CCN(C)CC2)CC1 10.1016/j.bmcl.2008.08.014
CHEMBL489588 193646 0 None - 1 Crab-eating macaque 5.9 pIC50 = 5.9 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 502 7 1 6 2.8 CCC(NC(=O)c1nc2ccccc2n1Cc1ccccc1)C(=O)N1CCN(C2CCN(C)CC2)CC1 10.1016/j.bmcl.2008.08.014
60142707 132699 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 544 5 2 6 5.8 Cc1nc(-c2c(F)cc(Cl)cc2-c2cc(F)c3c(c2)CCC3NC(=O)C2(NC(=O)OC(C)(C)C)CC2)no1 nan
CHEMBL3648481 132699 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 544 5 2 6 5.8 Cc1nc(-c2c(F)cc(Cl)cc2-c2cc(F)c3c(c2)CCC3NC(=O)C2(NC(=O)OC(C)(C)C)CC2)no1 nan
54580655 68963 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 566 7 2 5 3.8 Cc1ccc(S(=O)(=O)N2CC(C)(C)NC(=O)C2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
CHEMBL1777962 68963 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 566 7 2 5 3.8 Cc1ccc(S(=O)(=O)N2CC(C)(C)NC(=O)C2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
57399887 76887 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 466 4 1 5 1.3 Cc1cc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N2C[C@@H]3CN(C)C[C@@H]3C2)c(C)cc1Cl 10.1016/j.bmcl.2011.11.112
CHEMBL1939952 76887 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 466 4 1 5 1.3 Cc1cc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N2C[C@@H]3CN(C)C[C@@H]3C2)c(C)cc1Cl 10.1016/j.bmcl.2011.11.112
56672397 72647 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human B1 receptor by cell-based assayAntagonist activity at human B1 receptor by cell-based assay
ChEMBL 432 9 1 3 5.6 O=C(CCCCC(=O)c1ccccc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1021/jm200808v
CHEMBL1835752 72647 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human B1 receptor by cell-based assayAntagonist activity at human B1 receptor by cell-based assay
ChEMBL 432 9 1 3 5.6 O=C(CCCCC(=O)c1ccccc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1021/jm200808v
57399671 76344 0 None -2 2 Rabbit 6.9 pIC50 = 6.9 Functional
Antagonist activity at rabbit B1 bradykinin receptor expressed in CHO cellsAntagonist activity at rabbit B1 bradykinin receptor expressed in CHO cells
ChEMBL 506 5 1 4 6.6 Cc1cccc2occ(-c3ccc(C(=O)N[C@H]4CCCc5cc(CN6CCCCC6)ccc54)cc3)c(=O)c12 10.1016/j.bmcl.2011.10.068
CHEMBL1934265 76344 0 None -2 2 Rabbit 6.9 pIC50 = 6.9 Functional
Antagonist activity at rabbit B1 bradykinin receptor expressed in CHO cellsAntagonist activity at rabbit B1 bradykinin receptor expressed in CHO cells
ChEMBL 506 5 1 4 6.6 Cc1cccc2occ(-c3ccc(C(=O)N[C@H]4CCCc5cc(CN6CCCCC6)ccc54)cc3)c(=O)c12 10.1016/j.bmcl.2011.10.068
44579943 193575 0 None - 1 Crab-eating macaque 7.9 pIC50 = 7.9 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 494 8 1 6 3.2 CN(Cc1ccc(C2=NCCN2C)cc1)C(=O)CNC(=O)c1nc2ccccc2n1Cc1ccccc1 10.1016/j.bmcl.2008.08.014
CHEMBL489191 193575 0 None - 1 Crab-eating macaque 7.9 pIC50 = 7.9 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 494 8 1 6 3.2 CN(Cc1ccc(C2=NCCN2C)cc1)C(=O)CNC(=O)c1nc2ccccc2n1Cc1ccccc1 10.1016/j.bmcl.2008.08.014
16108965 168109 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilizationAntagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilization
ChEMBL 646 9 2 6 4.9 CN1c2cc(CN3CCCCC3)ccc2[C@H](NC(=O)C[C@@H](NS(=O)(=O)c2ccc3ccccc3c2)c2ccccc2)CS1(=O)=O 10.1021/jm061224g
CHEMBL412552 168109 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilizationAntagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilization
ChEMBL 646 9 2 6 4.9 CN1c2cc(CN3CCCCC3)ccc2[C@H](NC(=O)C[C@@H](NS(=O)(=O)c2ccc3ccccc3c2)c2ccccc2)CS1(=O)=O 10.1021/jm061224g
16221057 149798 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 607 11 3 5 5.6 CC(C)CNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1 10.1021/jm070055c
CHEMBL389478 149798 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 607 11 3 5 5.6 CC(C)CNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1 10.1021/jm070055c
16221161 151099 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 569 9 2 5 5.5 O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCOc2cc(CN3CCCC3)ccc21 10.1021/jm070055c
CHEMBL390539 151099 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 569 9 2 5 5.5 O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCOc2cc(CN3CCCC3)ccc21 10.1021/jm070055c
44410313 82576 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Inhibition of human B1 receptor by calcium influx functional assayInhibition of human B1 receptor by calcium influx functional assay
ChEMBL 527 8 2 5 4.7 COc1ccc(S(=O)(=O)N2CCCC[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC(C)(C)C)ccc32)cc1 10.1016/j.bmcl.2006.01.069
CHEMBL204847 82576 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Inhibition of human B1 receptor by calcium influx functional assayInhibition of human B1 receptor by calcium influx functional assay
ChEMBL 527 8 2 5 4.7 COc1ccc(S(=O)(=O)N2CCCC[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC(C)(C)C)ccc32)cc1 10.1016/j.bmcl.2006.01.069
11685446 193483 0 None -14 2 Rabbit 6.9 pIC50 = 6.9 Functional
Antagonist activity at rabbit bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assayAntagonist activity at rabbit bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assay
ChEMBL 554 8 3 6 3.7 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1cccc(Cl)c1Cl 10.1016/j.bmcl.2008.07.108
CHEMBL488501 193483 0 None -14 2 Rabbit 6.9 pIC50 = 6.9 Functional
Antagonist activity at rabbit bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assayAntagonist activity at rabbit bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assay
ChEMBL 554 8 3 6 3.7 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1cccc(Cl)c1Cl 10.1016/j.bmcl.2008.07.108
56594771 72554 0 None 2 2 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human B1 receptor expressed in CHO cells by aequorin-based calcium flux assayAntagonist activity at human B1 receptor expressed in CHO cells by aequorin-based calcium flux assay
ChEMBL 507 5 1 6 4.9 Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2cccnc12 10.1021/jm200808v
CHEMBL1834749 72554 0 None 2 2 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human B1 receptor expressed in CHO cells by aequorin-based calcium flux assayAntagonist activity at human B1 receptor expressed in CHO cells by aequorin-based calcium flux assay
ChEMBL 507 5 1 6 4.9 Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2cccnc12 10.1021/jm200808v
46230069 207804 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 555 5 2 4 5.2 CC(C)N(NC(=O)c1cc(F)cc(C(F)(F)F)c1)C(=O)N[C@H](C)c1ncc(C(=O)N2[C@@H](C)CC[C@H]2C)cc1F 10.1016/j.bmcl.2009.11.119
CHEMBL602320 207804 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 555 5 2 4 5.2 CC(C)N(NC(=O)c1cc(F)cc(C(F)(F)F)c1)C(=O)N[C@H](C)c1ncc(C(=O)N2[C@@H](C)CC[C@H]2C)cc1F 10.1016/j.bmcl.2009.11.119
49863229 21996 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium flux
ChEMBL 627 10 3 5 5.4 C=C(CN1CC[C@@H](O)C1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2010.06.010
CHEMBL1210746 21996 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium flux
ChEMBL 627 10 3 5 5.4 C=C(CN1CC[C@@H](O)C1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2010.06.010
44579828 200085 0 None 1 2 Rat 7.8 pIC50 = 7.8 Functional
Antagonist activity at rat bradykinin B1 receptorAntagonist activity at rat bradykinin B1 receptor
ChEMBL 502 7 0 6 2.8 CCN(CC(=O)N1CCN(C2CCN(C)CC2)CC1)C(=O)c1nc2ccccc2n1Cc1ccccc1 10.1016/j.bmcl.2008.08.014
CHEMBL524126 200085 0 None 1 2 Rat 7.8 pIC50 = 7.8 Functional
Antagonist activity at rat bradykinin B1 receptorAntagonist activity at rat bradykinin B1 receptor
ChEMBL 502 7 0 6 2.8 CCN(CC(=O)N1CCN(C2CCN(C)CC2)CC1)C(=O)c1nc2ccccc2n1Cc1ccccc1 10.1016/j.bmcl.2008.08.014
57399886 76883 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 468 5 1 5 1.9 Cc1cc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N2CCC(N(C)C)CC2)c(C)cc1Cl 10.1016/j.bmcl.2011.11.112
CHEMBL1939948 76883 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 468 5 1 5 1.9 Cc1cc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N2CCC(N(C)C)CC2)c(C)cc1Cl 10.1016/j.bmcl.2011.11.112
49863231 21998 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium flux
ChEMBL 585 10 2 4 5.9 C=C(CN(C)C)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2010.06.010
CHEMBL1210748 21998 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium flux
ChEMBL 585 10 2 4 5.9 C=C(CN(C)C)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2010.06.010
44579795 193724 0 None -30 2 Rat 6.8 pIC50 = 6.8 Functional
Antagonist activity at rat bradykinin B1 receptorAntagonist activity at rat bradykinin B1 receptor
ChEMBL 480 8 2 6 2.8 CN(Cc1ccc(C2=NCCN2)cc1)C(=O)CNC(=O)c1nc2ccccc2n1Cc1ccccc1 10.1016/j.bmcl.2008.08.014
CHEMBL490201 193724 0 None -30 2 Rat 6.8 pIC50 = 6.8 Functional
Antagonist activity at rat bradykinin B1 receptorAntagonist activity at rat bradykinin B1 receptor
ChEMBL 480 8 2 6 2.8 CN(Cc1ccc(C2=NCCN2)cc1)C(=O)CNC(=O)c1nc2ccccc2n1Cc1ccccc1 10.1016/j.bmcl.2008.08.014
44579828 200085 0 None -1 2 Crab-eating macaque 7.8 pIC50 = 7.8 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 502 7 0 6 2.8 CCN(CC(=O)N1CCN(C2CCN(C)CC2)CC1)C(=O)c1nc2ccccc2n1Cc1ccccc1 10.1016/j.bmcl.2008.08.014
CHEMBL524126 200085 0 None -1 2 Crab-eating macaque 7.8 pIC50 = 7.8 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 502 7 0 6 2.8 CCN(CC(=O)N1CCN(C2CCN(C)CC2)CC1)C(=O)c1nc2ccccc2n1Cc1ccccc1 10.1016/j.bmcl.2008.08.014
11317669 156118 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 481 5 3 4 3.2 C[C@@H](NC(=O)c1n[nH]c(NC(=O)c2ccccc2Cl)c1Br)C(=O)N1CCCCC1 10.1021/jm051292n
CHEMBL394514 156118 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 481 5 3 4 3.2 C[C@@H](NC(=O)c1n[nH]c(NC(=O)c2ccccc2Cl)c1Br)C(=O)N1CCCCC1 10.1021/jm051292n
11204003 83996 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Inhibition of human B1 receptor by calcium influx functional assayInhibition of human B1 receptor by calcium influx functional assay
ChEMBL 579 7 2 4 6.0 Cc1ccc(S(=O)(=O)N2CCCC[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC(C)(C)C)ccc32)cc1C(F)(F)F 10.1016/j.bmcl.2006.01.069
CHEMBL207947 83996 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Inhibition of human B1 receptor by calcium influx functional assayInhibition of human B1 receptor by calcium influx functional assay
ChEMBL 579 7 2 4 6.0 Cc1ccc(S(=O)(=O)N2CCCC[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC(C)(C)C)ccc32)cc1C(F)(F)F 10.1016/j.bmcl.2006.01.069
665 7760 3 None -89 4 Dog 7.8 pIC50 = 7.8 Functional
Antagonist activity at dog bradykinin B1 receptorAntagonist activity at dog bradykinin B1 receptor
ChEMBL 585 8 3 6 3.6 O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 10.1021/jm1000776
9916412 7760 3 None -89 4 Dog 7.8 pIC50 = 7.8 Functional
Antagonist activity at dog bradykinin B1 receptorAntagonist activity at dog bradykinin B1 receptor
ChEMBL 585 8 3 6 3.6 O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 10.1021/jm1000776
CHEMBL189123 7760 3 None -89 4 Dog 7.8 pIC50 = 7.8 Functional
Antagonist activity at dog bradykinin B1 receptorAntagonist activity at dog bradykinin B1 receptor
ChEMBL 585 8 3 6 3.6 O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 10.1021/jm1000776
44410328 82780 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Inhibition of human B1 receptor by calcium influx functional assayInhibition of human B1 receptor by calcium influx functional assay
ChEMBL 537 7 1 4 4.9 CN(C)Cc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2006.01.069
CHEMBL205501 82780 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Inhibition of human B1 receptor by calcium influx functional assayInhibition of human B1 receptor by calcium influx functional assay
ChEMBL 537 7 1 4 4.9 CN(C)Cc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2006.01.069
23630615 99885 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 601 10 2 7 4.5 CN(C)CCn1nc(C(=O)NCCC2CCN(c3ccncc3)CC2)c(Br)c1NC(=O)c1ccccc1Cl 10.1021/jm051292n
CHEMBL244284 99885 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 601 10 2 7 4.5 CN(C)CCn1nc(C(=O)NCCC2CCN(c3ccncc3)CC2)c(Br)c1NC(=O)c1ccccc1Cl 10.1021/jm051292n
CHEMBL3038104 217716 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
In vitro Bradykinin receptor B1 antagonist activity in functional tissue within rabbit aortaIn vitro Bradykinin receptor B1 antagonist activity in functional tissue within rabbit aorta
ChEMBL None None None NC(N)=NCCC[C@@H](N)C(=O)N[C@@H](CCCNC(N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N(CC(=O)O)C1CCCCC1 10.1021/jm950716i
16220917 173114 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 543 9 2 5 5.0 CN(C)Cc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 10.1021/jm070055c
CHEMBL427279 173114 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 543 9 2 5 5.0 CN(C)Cc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 10.1021/jm070055c
16221056 92334 0 None -97 2 Rabbit 5.8 pIC50 = 5.8 Functional
Antagonist activity at rabbit bradykinin B1 receptorAntagonist activity at rabbit bradykinin B1 receptor
ChEMBL 609 12 3 6 4.6 COCCNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1 10.1021/jm070055c
CHEMBL227870 92334 0 None -97 2 Rabbit 5.8 pIC50 = 5.8 Functional
Antagonist activity at rabbit bradykinin B1 receptorAntagonist activity at rabbit bradykinin B1 receptor
ChEMBL 609 12 3 6 4.6 COCCNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1 10.1021/jm070055c
46230834 206043 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 409 4 2 6 3.6 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc(CNC(=O)N(C)O)c(F)c2)no1 10.1016/j.bmcl.2009.11.121
CHEMBL590151 206043 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 409 4 2 6 3.6 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc(CNC(=O)N(C)O)c(F)c2)no1 10.1016/j.bmcl.2009.11.121
46230893 207151 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 409 4 2 7 2.4 CN(O)C(=O)NCc1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F 10.1016/j.bmcl.2009.11.121
CHEMBL597840 207151 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 409 4 2 7 2.4 CN(O)C(=O)NCc1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F 10.1016/j.bmcl.2009.11.121
57390932 76333 0 None 14 2 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human B1 bradykinin receptor expressed in CHO cells by aqueorin-based calcium flux assayAntagonist activity at human B1 bradykinin receptor expressed in CHO cells by aqueorin-based calcium flux assay
ChEMBL 526 5 1 4 6.9 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3cccc(Cl)c3c2=O)c1 10.1016/j.bmcl.2011.10.068
CHEMBL1934254 76333 0 None 14 2 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human B1 bradykinin receptor expressed in CHO cells by aqueorin-based calcium flux assayAntagonist activity at human B1 bradykinin receptor expressed in CHO cells by aqueorin-based calcium flux assay
ChEMBL 526 5 1 4 6.9 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3cccc(Cl)c3c2=O)c1 10.1016/j.bmcl.2011.10.068
16220916 92336 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 571 9 3 5 5.8 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 10.1021/jm070055c
CHEMBL227879 92336 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 571 9 3 5 5.8 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 10.1021/jm070055c
16108961 7710 0 None -10 3 Rabbit 7.8 pIC50 = 7.8 Functional
Antagonistic activity at rabbit bradykinin B1 receptor expressed in CHO-D cells assessed as effect on DAK-mediated calcium mobilizationAntagonistic activity at rabbit bradykinin B1 receptor expressed in CHO-D cells assessed as effect on DAK-mediated calcium mobilization
ChEMBL 583 9 2 5 5.9 O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 10.1021/jm061224g
664 7710 0 None -10 3 Rabbit 7.8 pIC50 = 7.8 Functional
Antagonistic activity at rabbit bradykinin B1 receptor expressed in CHO-D cells assessed as effect on DAK-mediated calcium mobilizationAntagonistic activity at rabbit bradykinin B1 receptor expressed in CHO-D cells assessed as effect on DAK-mediated calcium mobilization
ChEMBL 583 9 2 5 5.9 O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 10.1021/jm061224g
CHEMBL415848 7710 0 None -10 3 Rabbit 7.8 pIC50 = 7.8 Functional
Antagonistic activity at rabbit bradykinin B1 receptor expressed in CHO-D cells assessed as effect on DAK-mediated calcium mobilizationAntagonistic activity at rabbit bradykinin B1 receptor expressed in CHO-D cells assessed as effect on DAK-mediated calcium mobilization
ChEMBL 583 9 2 5 5.9 O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 10.1021/jm061224g
11526891 195657 0 None 1 2 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assay
ChEMBL 554 8 3 6 3.7 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2008.07.108
CHEMBL507168 195657 0 None 1 2 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assay
ChEMBL 554 8 3 6 3.7 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2008.07.108
16221056 92334 0 None 97 2 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 609 12 3 6 4.6 COCCNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1 10.1021/jm070055c
CHEMBL227870 92334 0 None 97 2 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 609 12 3 6 4.6 COCCNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1 10.1021/jm070055c
60141326 132724 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 444 4 2 7 3.1 Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)SCC3NC(=O)C2(N)CC2)n1 nan
CHEMBL3648506 132724 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 444 4 2 7 3.1 Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)SCC3NC(=O)C2(N)CC2)n1 nan
56594772 72555 0 None -15 2 Rabbit 7.8 pIC50 = 7.8 Functional
Inhibition of rabbit B1 receptor by cellular calcium flux assayInhibition of rabbit B1 receptor by cellular calcium flux assay
ChEMBL 542 5 1 6 5.6 Cc1nn(-c2ccc(C(=O)N[C@@H]3CCOc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2c(Cl)cccc12 10.1021/jm200808v
CHEMBL1834750 72555 0 None -15 2 Rabbit 7.8 pIC50 = 7.8 Functional
Inhibition of rabbit B1 receptor by cellular calcium flux assayInhibition of rabbit B1 receptor by cellular calcium flux assay
ChEMBL 542 5 1 6 5.6 Cc1nn(-c2ccc(C(=O)N[C@@H]3CCOc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2c(Cl)cccc12 10.1021/jm200808v
57396445 76860 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 419 5 2 4 2.4 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)NC2CCCCC2(C)C)cc1 10.1016/j.bmcl.2011.11.112
CHEMBL1939925 76860 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 419 5 2 4 2.4 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)NC2CCCCC2(C)C)cc1 10.1016/j.bmcl.2011.11.112
11213709 99098 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 475 6 4 4 3.0 NC(=O)[C@@H](NC(=O)c1n[nH]c(NC(=O)c2ccccc2Cl)c1Br)c1ccccc1 10.1021/jm051292n
CHEMBL242994 99098 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 475 6 4 4 3.0 NC(=O)[C@@H](NC(=O)c1n[nH]c(NC(=O)c2ccccc2Cl)c1Br)c1ccccc1 10.1021/jm051292n
16108964 148499 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilizationAntagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilization
ChEMBL 583 9 2 5 5.9 O=C(C[C@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@H]1CCOc2cc(CN3CCCCC3)ccc21 10.1021/jm061224g
CHEMBL385741 148499 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilizationAntagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilization
ChEMBL 583 9 2 5 5.9 O=C(C[C@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@H]1CCOc2cc(CN3CCCCC3)ccc21 10.1021/jm061224g
57398979 76840 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 469 6 2 5 2.5 COc1ccc2c(c1)C(NC(=O)C[C@@H]1C(=O)NC=CN1S(=O)(=O)c1ccc(C)cc1)CCC2 10.1016/j.bmcl.2011.11.112
CHEMBL1939764 76840 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 469 6 2 5 2.5 COc1ccc2c(c1)C(NC(=O)C[C@@H]1C(=O)NC=CN1S(=O)(=O)c1ccc(C)cc1)CCC2 10.1016/j.bmcl.2011.11.112
44579830 193772 0 None 1 2 Crab-eating macaque 7.8 pIC50 = 7.8 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 516 8 0 6 3.2 CCCN(CC(=O)N1CCN(C2CCN(C)CC2)CC1)C(=O)c1nc2ccccc2n1Cc1ccccc1 10.1016/j.bmcl.2008.08.014
CHEMBL490619 193772 0 None 1 2 Crab-eating macaque 7.8 pIC50 = 7.8 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 516 8 0 6 3.2 CCCN(CC(=O)N1CCN(C2CCN(C)CC2)CC1)C(=O)c1nc2ccccc2n1Cc1ccccc1 10.1016/j.bmcl.2008.08.014
57390219 76843 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 441 5 2 5 2.0 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCOc3ccccc32)cc1 10.1016/j.bmcl.2011.11.112
CHEMBL1939767 76843 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 441 5 2 5 2.0 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCOc3ccccc32)cc1 10.1016/j.bmcl.2011.11.112
46230258 207218 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilization
ChEMBL 486 6 2 7 5.2 CC(=O)Nn1c(NCc2ccc(-c3cc(Cl)cc(F)c3-c3noc(C)n3)cc2F)nc(C)c1C 10.1016/j.bmcl.2009.11.120
CHEMBL598348 207218 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilization
ChEMBL 486 6 2 7 5.2 CC(=O)Nn1c(NCc2ccc(-c3cc(Cl)cc(F)c3-c3noc(C)n3)cc2F)nc(C)c1C 10.1016/j.bmcl.2009.11.120
11512379 172784 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Inhibition of human B1 receptor by calcium influx functional assayInhibition of human B1 receptor by calcium influx functional assay
ChEMBL 555 7 2 7 4.7 CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2006.01.069
CHEMBL425416 172784 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Inhibition of human B1 receptor by calcium influx functional assayInhibition of human B1 receptor by calcium influx functional assay
ChEMBL 555 7 2 7 4.7 CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2006.01.069
11342079 168565 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilizationAntagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilization
ChEMBL 567 9 2 4 6.0 O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@H]1CCc2cc(CN3CCCCC3)ccc21 10.1021/jm061224g
CHEMBL414091 168565 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilizationAntagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilization
ChEMBL 567 9 2 4 6.0 O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@H]1CCc2cc(CN3CCCCC3)ccc21 10.1021/jm061224g
57392728 76342 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human B1 bradykinin receptor expressed in CHO cells by aqueorin-based calcium flux assayAntagonist activity at human B1 bradykinin receptor expressed in CHO cells by aqueorin-based calcium flux assay
ChEMBL 526 5 1 4 6.9 O=C(N[C@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3c(Cl)cccc3c2=O)cc1 10.1016/j.bmcl.2011.10.068
CHEMBL1934263 76342 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human B1 bradykinin receptor expressed in CHO cells by aqueorin-based calcium flux assayAntagonist activity at human B1 bradykinin receptor expressed in CHO cells by aqueorin-based calcium flux assay
ChEMBL 526 5 1 4 6.9 O=C(N[C@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3c(Cl)cccc3c2=O)cc1 10.1016/j.bmcl.2011.10.068
44579890 193395 0 None - 1 Crab-eating macaque 6.7 pIC50 = 6.7 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 534 7 1 6 3.9 CN(Cc1ccc(C2=NCCN2)cc1)C(=O)C1CCN(C(=O)c2nc3ccccc3n2Cc2ccccc2)CC1 10.1016/j.bmcl.2008.08.014
CHEMBL487909 193395 0 None - 1 Crab-eating macaque 6.7 pIC50 = 6.7 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 534 7 1 6 3.9 CN(Cc1ccc(C2=NCCN2)cc1)C(=O)C1CCN(C(=O)c2nc3ccccc3n2Cc2ccccc2)CC1 10.1016/j.bmcl.2008.08.014
57403175 76337 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human B1 bradykinin receptor expressed in CHO cells by aqueorin-based calcium flux assayAntagonist activity at human B1 bradykinin receptor expressed in CHO cells by aqueorin-based calcium flux assay
ChEMBL 526 5 1 4 6.9 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3c(Cl)cccc3c2=O)c1 10.1016/j.bmcl.2011.10.068
CHEMBL1934258 76337 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human B1 bradykinin receptor expressed in CHO cells by aqueorin-based calcium flux assayAntagonist activity at human B1 bradykinin receptor expressed in CHO cells by aqueorin-based calcium flux assay
ChEMBL 526 5 1 4 6.9 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3c(Cl)cccc3c2=O)c1 10.1016/j.bmcl.2011.10.068
57394686 76882 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 480 5 1 5 2.0 Cc1cc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N2CC[C@H](N3CCCC3)C2)c(C)cc1Cl 10.1016/j.bmcl.2011.11.112
CHEMBL1939947 76882 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 480 5 1 5 2.0 Cc1cc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N2CC[C@H](N3CCCC3)C2)c(C)cc1Cl 10.1016/j.bmcl.2011.11.112
16221108 92306 0 None 22 2 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 605 9 2 5 5.5 O=C(C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1)N[C@@H]1CCOc2cc(CN3CCCC3)ccc21 10.1021/jm070055c
CHEMBL227600 92306 0 None 22 2 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 605 9 2 5 5.5 O=C(C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1)N[C@@H]1CCOc2cc(CN3CCCC3)ccc21 10.1021/jm070055c
44579969 193680 0 None - 1 Crab-eating macaque 6.7 pIC50 = 6.7 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 509 9 1 5 4.5 CN(Cc1ccc(CN2CCCCC2)cc1)C(=O)CNC(=O)c1nc2ccccc2n1Cc1ccccc1 10.1016/j.bmcl.2008.08.014
CHEMBL489810 193680 0 None - 1 Crab-eating macaque 6.7 pIC50 = 6.7 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 509 9 1 5 4.5 CN(Cc1ccc(CN2CCCCC2)cc1)C(=O)CNC(=O)c1nc2ccccc2n1Cc1ccccc1 10.1016/j.bmcl.2008.08.014
44580043 191521 0 None - 1 Crab-eating macaque 5.7 pIC50 = 5.7 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 460 6 1 5 3.6 O=C(NCCC(=O)N1CCC2(CCOCC2)CC1)c1nc2ccccc2n1Cc1ccccc1 10.1016/j.bmcl.2008.08.014
CHEMBL485079 191521 0 None - 1 Crab-eating macaque 5.7 pIC50 = 5.7 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 460 6 1 5 3.6 O=C(NCCC(=O)N1CCC2(CCOCC2)CC1)c1nc2ccccc2n1Cc1ccccc1 10.1016/j.bmcl.2008.08.014
25105469 193840 6 None -2 2 Crab-eating macaque 8.7 pIC50 = 8.7 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 467 8 3 7 2.6 O=C(CCNC(=O)c1nc2ccccc2n1Cc1ccccc1)Nc1ccc(C2=NCCN2)nc1 10.1016/j.bmcl.2008.08.014
CHEMBL491198 193840 6 None -2 2 Crab-eating macaque 8.7 pIC50 = 8.7 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 467 8 3 7 2.6 O=C(CCNC(=O)c1nc2ccccc2n1Cc1ccccc1)Nc1ccc(C2=NCCN2)nc1 10.1016/j.bmcl.2008.08.014
60142027 132671 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 522 5 2 5 4.8 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 nan
CHEMBL3648454 132671 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 522 5 2 5 4.8 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 nan
54584600 68966 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 538 7 2 5 3.1 Cc1ccc(S(=O)(=O)N2CC(=O)NCC2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
CHEMBL1777965 68966 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 538 7 2 5 3.1 Cc1ccc(S(=O)(=O)N2CC(=O)NCC2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
56589598 72556 0 None -7 2 Rabbit 8.7 pIC50 = 8.7 Functional
Inhibition of rabbit B1 receptor by cellular calcium flux assayInhibition of rabbit B1 receptor by cellular calcium flux assay
ChEMBL 543 5 1 6 5.2 Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cn2)c(=O)c2c(F)ccc(F)c12 10.1021/jm200808v
CHEMBL1834751 72556 0 None -7 2 Rabbit 8.7 pIC50 = 8.7 Functional
Inhibition of rabbit B1 receptor by cellular calcium flux assayInhibition of rabbit B1 receptor by cellular calcium flux assay
ChEMBL 543 5 1 6 5.2 Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cn2)c(=O)c2c(F)ccc(F)c12 10.1021/jm200808v
46230835 207780 0 None - 1 Human 8.6 pIC50 = 8.6 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 439 4 2 6 4.6 Cc1nc(-c2c(Cl)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)N(C)O)c(F)c2)no1 10.1016/j.bmcl.2009.11.121
CHEMBL602115 207780 0 None - 1 Human 8.6 pIC50 = 8.6 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 439 4 2 6 4.6 Cc1nc(-c2c(Cl)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)N(C)O)c(F)c2)no1 10.1016/j.bmcl.2009.11.121
25195622 68956 0 None - 1 Human 8.6 pIC50 = 8.6 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 606 7 2 5 4.1 Cc1ccc(S(=O)(=O)N2CCNC(=O)C2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1C(F)(F)F 10.1016/j.bmcl.2011.03.115
CHEMBL1777955 68956 0 None - 1 Human 8.6 pIC50 = 8.6 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 606 7 2 5 4.1 Cc1ccc(S(=O)(=O)N2CCNC(=O)C2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1C(F)(F)F 10.1016/j.bmcl.2011.03.115
54587553 68980 0 None - 1 Human 8.6 pIC50 = 8.6 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 540 8 3 5 3.2 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNCC(C)(C)C)ccc32)cc1 10.1016/j.bmcl.2011.03.115
CHEMBL1777979 68980 0 None - 1 Human 8.6 pIC50 = 8.6 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 540 8 3 5 3.2 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNCC(C)(C)C)ccc32)cc1 10.1016/j.bmcl.2011.03.115
60142441 132689 0 None - 1 Human 8.6 pIC50 = 8.6 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 540 5 2 6 5.0 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)SCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 nan
CHEMBL3648471 132689 0 None - 1 Human 8.6 pIC50 = 8.6 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 540 5 2 6 5.0 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)SCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 nan
11442712 92001 0 None -9 2 Rabbit 8.6 pIC50 = 8.6 Functional
Activity at rabbit bradykinin B1 receptor assessed by FLIPR assayActivity at rabbit bradykinin B1 receptor assessed by FLIPR assay
ChEMBL 466 7 2 6 5.4 COC(=O)c1c(F)cccc1-c1ccc([C@@H](C)Nc2nccc(Cl)c2NC(=O)CC#N)cc1 10.1021/jm049394l
CHEMBL225607 92001 0 None -9 2 Rabbit 8.6 pIC50 = 8.6 Functional
Activity at rabbit bradykinin B1 receptor assessed by FLIPR assayActivity at rabbit bradykinin B1 receptor assessed by FLIPR assay
ChEMBL 466 7 2 6 5.4 COC(=O)c1c(F)cccc1-c1ccc([C@@H](C)Nc2nccc(Cl)c2NC(=O)CC#N)cc1 10.1021/jm049394l
54581666 68971 0 None - 1 Human 8.6 pIC50 = 8.6 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 566 7 2 5 3.7 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCC(C)(C)C4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
CHEMBL1777970 68971 0 None - 1 Human 8.6 pIC50 = 8.6 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 566 7 2 5 3.7 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCC(C)(C)C4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
57399382 76629 0 None - 1 Human 8.6 pIC50 = 8.6 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 482 5 1 5 2.3 Cc1cc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N2CCCC(N(C)C)CC2)c(C)cc1Cl 10.1016/j.bmcl.2011.11.112
CHEMBL1938412 76629 0 None - 1 Human 8.6 pIC50 = 8.6 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 482 5 1 5 2.3 Cc1cc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N2CCCC(N(C)C)CC2)c(C)cc1Cl 10.1016/j.bmcl.2011.11.112
60141042 132715 0 None - 1 Human 8.6 pIC50 = 8.6 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 537 6 2 8 3.8 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)c3ccno3)COC2)no1 nan
CHEMBL3648497 132715 0 None - 1 Human 8.6 pIC50 = 8.6 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 537 6 2 8 3.8 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)c3ccno3)COC2)no1 nan
11663809 180380 0 None -5 2 Rabbit 7.7 pIC50 = 7.7 Functional
Antagonist activity at rabbit bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assayAntagonist activity at rabbit bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assay
ChEMBL 536 8 3 6 3.5 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1ccc2ccccc2c1 10.1016/j.bmcl.2008.07.108
CHEMBL453339 180380 0 None -5 2 Rabbit 7.7 pIC50 = 7.7 Functional
Antagonist activity at rabbit bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assayAntagonist activity at rabbit bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assay
ChEMBL 536 8 3 6 3.5 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1ccc2ccccc2c1 10.1016/j.bmcl.2008.07.108
16221228 172796 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 593 10 3 5 5.4 CC(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1 10.1021/jm070055c
CHEMBL425490 172796 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 593 10 3 5 5.4 CC(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1 10.1021/jm070055c
57398239 76880 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 460 5 1 5 1.5 CN(C)[C@H]1CCN(C(=O)C[C@@H]2C(=O)NC=CN2S(=O)(=O)c2cccc(Cl)c2Cl)C1 10.1016/j.bmcl.2011.11.112
CHEMBL1939945 76880 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 460 5 1 5 1.5 CN(C)[C@H]1CCN(C(=O)C[C@@H]2C(=O)NC=CN2S(=O)(=O)c2cccc(Cl)c2Cl)C1 10.1016/j.bmcl.2011.11.112
11526891 195657 0 None -1 2 Rabbit 7.7 pIC50 = 7.7 Functional
Antagonist activity at rabbit bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assayAntagonist activity at rabbit bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assay
ChEMBL 554 8 3 6 3.7 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2008.07.108
CHEMBL507168 195657 0 None -1 2 Rabbit 7.7 pIC50 = 7.7 Functional
Antagonist activity at rabbit bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assayAntagonist activity at rabbit bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assay
ChEMBL 554 8 3 6 3.7 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2008.07.108
23630810 151280 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 452 7 3 5 3.7 O=C(NCCC1CCN(c2ccncc2)CC1)c1cc(NC(=O)c2ccccc2Cl)[nH]n1 10.1021/jm051292n
CHEMBL390692 151280 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 452 7 3 5 3.7 O=C(NCCC1CCN(c2ccncc2)CC1)c1cc(NC(=O)c2ccccc2Cl)[nH]n1 10.1021/jm051292n
137657568 166327 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity against bradykinin B1 receptor in human HeLa cells assessed as inhibition of Des-Arg9-BK-induced increase in intracellular Ca2+ level by Fluro-4 direct calcium dye based fluorescence assayAntagonist activity against bradykinin B1 receptor in human HeLa cells assessed as inhibition of Des-Arg9-BK-induced increase in intracellular Ca2+ level by Fluro-4 direct calcium dye based fluorescence assay
ChEMBL 1920 23 21 26 -5.4 CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N2 10.1021/acs.jmedchem.6b01011
CHEMBL4102547 166327 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity against bradykinin B1 receptor in human HeLa cells assessed as inhibition of Des-Arg9-BK-induced increase in intracellular Ca2+ level by Fluro-4 direct calcium dye based fluorescence assayAntagonist activity against bradykinin B1 receptor in human HeLa cells assessed as inhibition of Des-Arg9-BK-induced increase in intracellular Ca2+ level by Fluro-4 direct calcium dye based fluorescence assay
ChEMBL 1920 23 21 26 -5.4 CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N2 10.1021/acs.jmedchem.6b01011
16220988 92310 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 589 9 3 5 5.6 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccccc1C(F)(F)F)c1ccccc1 10.1021/jm070055c
CHEMBL227697 92310 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 589 9 3 5 5.6 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccccc1C(F)(F)F)c1ccccc1 10.1021/jm070055c
11405561 98982 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 354 4 3 3 3.9 Cc1c(C(=O)Nc2ccccc2)n[nH]c1NC(=O)c1ccccc1Cl 10.1021/jm051292n
CHEMBL242565 98982 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 354 4 3 3 3.9 Cc1c(C(=O)Nc2ccccc2)n[nH]c1NC(=O)c1ccccc1Cl 10.1021/jm051292n
16221053 149127 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 573 9 3 5 5.4 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(F)c(Cl)c1)c1ccccc1 10.1021/jm070055c
CHEMBL388720 149127 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 573 9 3 5 5.4 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(F)c(Cl)c1)c1ccccc1 10.1021/jm070055c
16220986 144395 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 555 9 3 5 5.3 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccccc1Cl)c1ccccc1 10.1021/jm070055c
CHEMBL375709 144395 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 555 9 3 5 5.3 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccccc1Cl)c1ccccc1 10.1021/jm070055c
17751868 76861 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 393 5 2 5 0.6 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)NC2CCOCC2)cc1 10.1016/j.bmcl.2011.11.112
CHEMBL1939926 76861 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 393 5 2 5 0.6 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)NC2CCOCC2)cc1 10.1016/j.bmcl.2011.11.112
49863230 21997 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium flux
ChEMBL 597 10 2 4 6.0 C=C(CN1CCC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2010.06.010
CHEMBL1210747 21997 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium flux
ChEMBL 597 10 2 4 6.0 C=C(CN1CCC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2010.06.010
16221226 151176 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 569 9 3 5 5.6 Cc1c(Cl)cccc1S(=O)(=O)N[C@H](CC(=O)N[C@@H]1CCOc2cc(CNC(C)(C)C)ccc21)c1ccccc1 10.1021/jm070055c
CHEMBL390603 151176 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 569 9 3 5 5.6 Cc1c(Cl)cccc1S(=O)(=O)N[C@H](CC(=O)N[C@@H]1CCOc2cc(CNC(C)(C)C)ccc21)c1ccccc1 10.1021/jm070055c
70691814 80628 0 None - 1 Rat 7.7 pIC50 = 7.7 Functional
Antagonist activity at rat bradykinin B1 receptorAntagonist activity at rat bradykinin B1 receptor
ChEMBL 592 8 2 5 5.6 Cc1cc(C)c(S(=O)(=O)N2c3ccccc3-c3ccccc3C2CC(=O)NCCc2ccc(C3=NCCN3)cc2)cc1C 10.1016/j.bmcl.2012.03.065
CHEMBL2018868 80628 0 None - 1 Rat 7.7 pIC50 = 7.7 Functional
Antagonist activity at rat bradykinin B1 receptorAntagonist activity at rat bradykinin B1 receptor
ChEMBL 592 8 2 5 5.6 Cc1cc(C)c(S(=O)(=O)N2c3ccccc3-c3ccccc3C2CC(=O)NCCc2ccc(C3=NCCN3)cc2)cc1C 10.1016/j.bmcl.2012.03.065
23627521 80633 0 None - 1 Rat 7.7 pIC50 = 7.7 Functional
Antagonist activity at rat bradykinin B1 receptorAntagonist activity at rat bradykinin B1 receptor
ChEMBL 648 9 2 6 6.0 COc1cccc2c1-c1ccccc1N(S(=O)(=O)c1ccc(Cl)c(Cl)c1)C2CC(=O)NCCc1ccc(C2=NCCN2)cc1 10.1016/j.bmcl.2012.03.065
CHEMBL2018873 80633 0 None - 1 Rat 7.7 pIC50 = 7.7 Functional
Antagonist activity at rat bradykinin B1 receptorAntagonist activity at rat bradykinin B1 receptor
ChEMBL 648 9 2 6 6.0 COc1cccc2c1-c1ccccc1N(S(=O)(=O)c1ccc(Cl)c(Cl)c1)C2CC(=O)NCCc1ccc(C2=NCCN2)cc1 10.1016/j.bmcl.2012.03.065
56594642 72497 0 None -21 2 Rabbit 7.7 pIC50 = 7.7 Functional
Inhibition of rabbit B1 receptor by cellular calcium flux assayInhibition of rabbit B1 receptor by cellular calcium flux assay
ChEMBL 540 5 1 5 6.1 Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2c(Cl)cccc12 10.1021/jm200808v
CHEMBL1834616 72497 0 None -21 2 Rabbit 7.7 pIC50 = 7.7 Functional
Inhibition of rabbit B1 receptor by cellular calcium flux assayInhibition of rabbit B1 receptor by cellular calcium flux assay
ChEMBL 540 5 1 5 6.1 Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2c(Cl)cccc12 10.1021/jm200808v
57398980 76844 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 440 5 3 5 2.0 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)NC2CCNc3ccccc32)cc1 10.1016/j.bmcl.2011.11.112
CHEMBL1939768 76844 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 440 5 3 5 2.0 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)NC2CCNc3ccccc32)cc1 10.1016/j.bmcl.2011.11.112
23630510 100072 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 446 5 3 3 4.6 C[C@@H](NC(=O)c1n[nH]c(NC(=O)c2ccccc2Cl)c1Br)c1ccccc1 10.1021/jm051292n
CHEMBL245129 100072 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 446 5 3 3 4.6 C[C@@H](NC(=O)c1n[nH]c(NC(=O)c2ccccc2Cl)c1Br)c1ccccc1 10.1021/jm051292n
11635364 181341 0 None -4 2 Rabbit 6.7 pIC50 = 6.7 Functional
Antagonist activity at rabbit bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assayAntagonist activity at rabbit bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assay
ChEMBL 554 8 3 6 3.4 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1ccc(C(F)(F)F)cc1 10.1016/j.bmcl.2008.07.108
CHEMBL455643 181341 0 None -4 2 Rabbit 6.7 pIC50 = 6.7 Functional
Antagonist activity at rabbit bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assayAntagonist activity at rabbit bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assay
ChEMBL 554 8 3 6 3.4 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1ccc(C(F)(F)F)cc1 10.1016/j.bmcl.2008.07.108
44410186 83992 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Inhibition of human B1 receptor by calcium influx functional assayInhibition of human B1 receptor by calcium influx functional assay
ChEMBL 615 8 2 4 6.4 CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1ccc(C(F)(F)C(F)(F)F)cc1 10.1016/j.bmcl.2006.01.069
CHEMBL207945 83992 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Inhibition of human B1 receptor by calcium influx functional assayInhibition of human B1 receptor by calcium influx functional assay
ChEMBL 615 8 2 4 6.4 CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1ccc(C(F)(F)C(F)(F)F)cc1 10.1016/j.bmcl.2006.01.069
16220914 92344 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 529 9 3 5 4.6 CNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 10.1021/jm070055c
CHEMBL228014 92344 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 529 9 3 5 4.6 CNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 10.1021/jm070055c
44580013 193826 0 None - 1 Crab-eating macaque 5.7 pIC50 = 5.7 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 478 8 2 5 3.9 CN(Cc1ccc(-c2ccn[nH]2)cc1)C(=O)CNC(=O)c1nc2ccccc2n1Cc1ccccc1 10.1016/j.bmcl.2008.08.014
CHEMBL491042 193826 0 None - 1 Crab-eating macaque 5.7 pIC50 = 5.7 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 478 8 2 5 3.9 CN(Cc1ccc(-c2ccn[nH]2)cc1)C(=O)CNC(=O)c1nc2ccccc2n1Cc1ccccc1 10.1016/j.bmcl.2008.08.014
11444165 147657 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Inhibition of human B1 receptor by calcium influx functional assayInhibition of human B1 receptor by calcium influx functional assay
ChEMBL 545 7 2 4 5.7 Cc1ccc(S(=O)(=O)N2CCCC[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC(C)(C)C)ccc32)cc1Cl 10.1016/j.bmcl.2006.01.069
CHEMBL381979 147657 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Inhibition of human B1 receptor by calcium influx functional assayInhibition of human B1 receptor by calcium influx functional assay
ChEMBL 545 7 2 4 5.7 Cc1ccc(S(=O)(=O)N2CCCC[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC(C)(C)C)ccc32)cc1Cl 10.1016/j.bmcl.2006.01.069
60142024 132668 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 446 5 2 4 3.5 COC(=O)c1ccccc1-c1ccc2c(c1)CCC2NC(=O)C1(NC(=O)C(F)(F)F)CC1 nan
CHEMBL3648451 132668 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 446 5 2 4 3.5 COC(=O)c1ccccc1-c1ccc2c(c1)CCC2NC(=O)C1(NC(=O)C(F)(F)F)CC1 nan
49863233 22000 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium flux
ChEMBL 615 13 3 5 5.6 C=C(CNCCOC)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2010.06.010
CHEMBL1210750 22000 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium flux
ChEMBL 615 13 3 5 5.6 C=C(CNCCOC)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2010.06.010
44587207 194927 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cellsAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells
ChEMBL 573 6 2 6 4.4 O=Cc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2008.07.055
CHEMBL498489 194927 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cellsAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells
ChEMBL 573 6 2 6 4.4 O=Cc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2008.07.055
23630811 99099 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 470 7 3 5 3.9 O=C(Nc1[nH]nc(C(=O)NCCC2CCN(c3ccncc3)CC2)c1F)c1ccccc1Cl 10.1021/jm051292n
CHEMBL242995 99099 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 470 7 3 5 3.9 O=C(Nc1[nH]nc(C(=O)NCCC2CCN(c3ccncc3)CC2)c1F)c1ccccc1Cl 10.1021/jm051292n
44579830 193772 0 None -1 2 Rat 7.6 pIC50 = 7.6 Functional
Antagonist activity at rat bradykinin B1 receptorAntagonist activity at rat bradykinin B1 receptor
ChEMBL 516 8 0 6 3.2 CCCN(CC(=O)N1CCN(C2CCN(C)CC2)CC1)C(=O)c1nc2ccccc2n1Cc1ccccc1 10.1016/j.bmcl.2008.08.014
CHEMBL490619 193772 0 None -1 2 Rat 7.6 pIC50 = 7.6 Functional
Antagonist activity at rat bradykinin B1 receptorAntagonist activity at rat bradykinin B1 receptor
ChEMBL 516 8 0 6 3.2 CCCN(CC(=O)N1CCN(C2CCN(C)CC2)CC1)C(=O)c1nc2ccccc2n1Cc1ccccc1 10.1016/j.bmcl.2008.08.014
57394688 76885 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 508 5 1 5 2.8 Cc1cc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N2CCCC[C@H](N3CCCC3)C2)c(C)cc1Cl 10.1016/j.bmcl.2011.11.112
CHEMBL1939950 76885 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 508 5 1 5 2.8 Cc1cc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N2CCCC[C@H](N3CCCC3)C2)c(C)cc1Cl 10.1016/j.bmcl.2011.11.112
11307733 81671 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Inhibition of human B1 receptor by calcium influx functional assayInhibition of human B1 receptor by calcium influx functional assay
ChEMBL 579 8 2 4 6.0 CC(C)(C)CNCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2006.01.069
CHEMBL203174 81671 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Inhibition of human B1 receptor by calcium influx functional assayInhibition of human B1 receptor by calcium influx functional assay
ChEMBL 579 8 2 4 6.0 CC(C)(C)CNCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2006.01.069
44579866 199965 0 None - 1 Crab-eating macaque 5.6 pIC50 = 5.6 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 508 5 0 6 3.7 O=C(c1nc2ccccc2n1Cc1ccccc1)N1CCC(C(=O)N2CCN(c3ccncc3)CC2)CC1 10.1016/j.bmcl.2008.08.014
CHEMBL523266 199965 0 None - 1 Crab-eating macaque 5.6 pIC50 = 5.6 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 508 5 0 6 3.7 O=C(c1nc2ccccc2n1Cc1ccccc1)N1CCC(C(=O)N2CCN(c3ccncc3)CC2)CC1 10.1016/j.bmcl.2008.08.014
54585539 68974 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 470 6 3 5 1.5 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN)ccc32)cc1 10.1016/j.bmcl.2011.03.115
CHEMBL1777973 68974 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 470 6 3 5 1.5 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN)ccc32)cc1 10.1016/j.bmcl.2011.03.115
54585539 68974 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 470 6 3 5 1.5 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN)ccc32)cc1 10.1016/j.bmcl.2011.11.112
CHEMBL1777973 68974 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 470 6 3 5 1.5 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN)ccc32)cc1 10.1016/j.bmcl.2011.11.112
56835163 76343 0 None -1 2 Rabbit 7.6 pIC50 = 7.6 Functional
Antagonist activity at rabbit B1 bradykinin receptor expressed in CHO cellsAntagonist activity at rabbit B1 bradykinin receptor expressed in CHO cells
ChEMBL 510 5 1 4 6.4 O=C(N[C@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3cccc(F)c3c2=O)cc1 10.1016/j.bmcl.2011.10.068
CHEMBL1934264 76343 0 None -1 2 Rabbit 7.6 pIC50 = 7.6 Functional
Antagonist activity at rabbit B1 bradykinin receptor expressed in CHO cellsAntagonist activity at rabbit B1 bradykinin receptor expressed in CHO cells
ChEMBL 510 5 1 4 6.4 O=C(N[C@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3cccc(F)c3c2=O)cc1 10.1016/j.bmcl.2011.10.068
16220990 92321 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 589 9 3 5 5.9 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(Cl)c(Cl)c1)c1ccccc1 10.1021/jm070055c
CHEMBL227786 92321 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 589 9 3 5 5.9 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(Cl)c(Cl)c1)c1ccccc1 10.1021/jm070055c
60142167 132675 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 538 5 2 7 2.9 Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)C(F)(F)F)COC2)n1 nan
CHEMBL3648458 132675 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 538 5 2 7 2.9 Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)C(F)(F)F)COC2)n1 nan
88925471 132683 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 538 5 2 7 3.5 Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)OCCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)n1 nan
CHEMBL3648465 132683 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 538 5 2 7 3.5 Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)OCCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)n1 nan
60142305 132682 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 538 5 2 6 4.7 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)OCCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 nan
CHEMBL3648464 132682 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 538 5 2 6 4.7 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)OCCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 nan
44410143 84111 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Inhibition of human B1 receptor by calcium influx functional assayInhibition of human B1 receptor by calcium influx functional assay
ChEMBL 497 7 2 4 4.7 CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1ccccc1 10.1016/j.bmcl.2006.01.069
CHEMBL208386 84111 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Inhibition of human B1 receptor by calcium influx functional assayInhibition of human B1 receptor by calcium influx functional assay
ChEMBL 497 7 2 4 4.7 CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1ccccc1 10.1016/j.bmcl.2006.01.069
54587550 68960 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 538 7 2 5 3.1 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
CHEMBL1777959 68960 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 538 7 2 5 3.1 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
57390932 76333 0 None -14 2 Rabbit 6.6 pIC50 = 6.6 Functional
Antagonist activity at rabbit B1 bradykinin receptor expressed in CHO cellsAntagonist activity at rabbit B1 bradykinin receptor expressed in CHO cells
ChEMBL 526 5 1 4 6.9 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3cccc(Cl)c3c2=O)c1 10.1016/j.bmcl.2011.10.068
CHEMBL1934254 76333 0 None -14 2 Rabbit 6.6 pIC50 = 6.6 Functional
Antagonist activity at rabbit B1 bradykinin receptor expressed in CHO cellsAntagonist activity at rabbit B1 bradykinin receptor expressed in CHO cells
ChEMBL 526 5 1 4 6.9 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3cccc(Cl)c3c2=O)c1 10.1016/j.bmcl.2011.10.068
17751827 76863 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 421 5 2 5 1.3 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)NC2CCOCC2(C)C)cc1 10.1016/j.bmcl.2011.11.112
CHEMBL1939928 76863 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 421 5 2 5 1.3 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)NC2CCOCC2(C)C)cc1 10.1016/j.bmcl.2011.11.112
44561643 192427 0 None -5 2 Rabbit 7.6 pIC50 = 7.6 Functional
Antagonist activity at rabbit bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assayAntagonist activity at rabbit bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assay
ChEMBL 542 8 3 6 3.7 CC(C)(C)c1ccc(S(=O)(=O)C[C@@H](O)[C@@H](O)C(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2008.07.108
CHEMBL486456 192427 0 None -5 2 Rabbit 7.6 pIC50 = 7.6 Functional
Antagonist activity at rabbit bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assayAntagonist activity at rabbit bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assay
ChEMBL 542 8 3 6 3.7 CC(C)(C)c1ccc(S(=O)(=O)C[C@@H](O)[C@@H](O)C(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2008.07.108
57391172 76859 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 405 5 2 4 2.0 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)NC2CCCCC2C)cc1 10.1016/j.bmcl.2011.11.112
CHEMBL1939924 76859 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 405 5 2 4 2.0 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)NC2CCCCC2C)cc1 10.1016/j.bmcl.2011.11.112
71449505 87699 0 None -3 2 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at human bradykinin B1 receptor expressed in human CHO cells assessed as inhibition of calcium flux by FLIPR assayAntagonist activity at human bradykinin B1 receptor expressed in human CHO cells assessed as inhibition of calcium flux by FLIPR assay
ChEMBL 475 8 1 5 5.0 COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)CCCc2ccc3cccnc3n2)c(F)c1 10.1016/j.bmcl.2011.04.091
CHEMBL2153436 87699 0 None -3 2 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at human bradykinin B1 receptor expressed in human CHO cells assessed as inhibition of calcium flux by FLIPR assayAntagonist activity at human bradykinin B1 receptor expressed in human CHO cells assessed as inhibition of calcium flux by FLIPR assay
ChEMBL 475 8 1 5 5.0 COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)CCCc2ccc3cccnc3n2)c(F)c1 10.1016/j.bmcl.2011.04.091
16221225 176147 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 589 9 3 5 5.9 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(Cl)cc1Cl)c1ccccc1 10.1021/jm070055c
CHEMBL442056 176147 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 589 9 3 5 5.9 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(Cl)cc1Cl)c1ccccc1 10.1021/jm070055c
57401426 76341 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human B1 bradykinin receptor expressed in CHO cells by aqueorin-based calcium flux assayAntagonist activity at human B1 bradykinin receptor expressed in CHO cells by aqueorin-based calcium flux assay
ChEMBL 526 5 1 4 6.9 O=C(N[C@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3cc(Cl)ccc3c2=O)cc1 10.1016/j.bmcl.2011.10.068
CHEMBL1934262 76341 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human B1 bradykinin receptor expressed in CHO cells by aqueorin-based calcium flux assayAntagonist activity at human B1 bradykinin receptor expressed in CHO cells by aqueorin-based calcium flux assay
ChEMBL 526 5 1 4 6.9 O=C(N[C@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3cc(Cl)ccc3c2=O)cc1 10.1016/j.bmcl.2011.10.068
24946440 199831 0 None - 1 Crab-eating macaque 6.6 pIC50 = 6.6 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 488 6 0 6 2.4 CN1CCC(N2CCN(C(=O)CN(C)C(=O)c3nc4ccccc4n3Cc3ccccc3)CC2)CC1 10.1016/j.bmcl.2008.08.014
CHEMBL522308 199831 0 None - 1 Crab-eating macaque 6.6 pIC50 = 6.6 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 488 6 0 6 2.4 CN1CCC(N2CCN(C(=O)CN(C)C(=O)c3nc4ccccc4n3Cc3ccccc3)CC2)CC1 10.1016/j.bmcl.2008.08.014
44579812 193914 0 None - 1 Crab-eating macaque 6.6 pIC50 = 6.6 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 482 7 0 6 3.3 CCN(CC(=O)N1CCN(c2ccncc2)CC1)C(=O)c1nc2ccccc2n1Cc1ccccc1 10.1016/j.bmcl.2008.08.014
CHEMBL491830 193914 0 None - 1 Crab-eating macaque 6.6 pIC50 = 6.6 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 482 7 0 6 3.3 CCN(CC(=O)N1CCN(c2ccncc2)CC1)C(=O)c1nc2ccccc2n1Cc1ccccc1 10.1016/j.bmcl.2008.08.014
57390933 76334 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human B1 bradykinin receptor expressed in CHO cells by aqueorin-based calcium flux assayAntagonist activity at human B1 bradykinin receptor expressed in CHO cells by aqueorin-based calcium flux assay
ChEMBL 526 5 1 4 6.9 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3ccc(Cl)cc3c2=O)c1 10.1016/j.bmcl.2011.10.068
CHEMBL1934255 76334 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human B1 bradykinin receptor expressed in CHO cells by aqueorin-based calcium flux assayAntagonist activity at human B1 bradykinin receptor expressed in CHO cells by aqueorin-based calcium flux assay
ChEMBL 526 5 1 4 6.9 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3ccc(Cl)cc3c2=O)c1 10.1016/j.bmcl.2011.10.068
46229968 208164 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 538 6 2 4 4.5 C[C@H]1CC[C@@H](C)N1C(=O)c1cnc([C@@H](C)NC(=O)C2(NC(=O)c3cc(F)cc(C(F)(F)F)c3)CC2)c(F)c1 10.1016/j.bmcl.2009.11.119
CHEMBL604575 208164 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 538 6 2 4 4.5 C[C@H]1CC[C@@H](C)N1C(=O)c1cnc([C@@H](C)NC(=O)C2(NC(=O)c3cc(F)cc(C(F)(F)F)c3)CC2)c(F)c1 10.1016/j.bmcl.2009.11.119
23627396 80627 0 None - 1 Rat 7.6 pIC50 = 7.6 Functional
Antagonist activity at rat bradykinin B1 receptorAntagonist activity at rat bradykinin B1 receptor
ChEMBL 618 8 2 5 6.0 O=C(CC1c2ccccc2-c2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)NCCc1ccc(C2=NCCN2)cc1 10.1016/j.bmcl.2012.03.065
CHEMBL2018867 80627 0 None - 1 Rat 7.6 pIC50 = 7.6 Functional
Antagonist activity at rat bradykinin B1 receptorAntagonist activity at rat bradykinin B1 receptor
ChEMBL 618 8 2 5 6.0 O=C(CC1c2ccccc2-c2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)NCCc1ccc(C2=NCCN2)cc1 10.1016/j.bmcl.2012.03.065
60142166 132674 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 538 5 2 6 4.1 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)C(F)(F)F)COC2)no1 nan
CHEMBL3648457 132674 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 538 5 2 6 4.1 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)C(F)(F)F)COC2)no1 nan
11375297 99347 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 490 6 3 5 3.7 COC(=O)[C@@H](NC(=O)c1n[nH]c(NC(=O)c2ccccc2Cl)c1Br)c1ccccc1 10.1021/jm051292n
CHEMBL243467 99347 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 490 6 3 5 3.7 COC(=O)[C@@H](NC(=O)c1n[nH]c(NC(=O)c2ccccc2Cl)c1Br)c1ccccc1 10.1021/jm051292n
23630509 100045 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 453 4 4 4 2.5 O=C(Nc1[nH]nc(C(=O)N[C@@H]2CCCCNC2=O)c1Br)c1ccccc1Cl 10.1021/jm051292n
CHEMBL244955 100045 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 453 4 4 4 2.5 O=C(Nc1[nH]nc(C(=O)N[C@@H]2CCCCNC2=O)c1Br)c1ccccc1Cl 10.1021/jm051292n
44580044 191522 0 None - 1 Crab-eating macaque 5.5 pIC50 = 5.5 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 459 6 1 5 3.1 CN1CCC2(CCN(C(=O)CCNC(=O)c3nc4ccccc4n3Cc3ccccc3)CC2)C1 10.1016/j.bmcl.2008.08.014
CHEMBL485080 191522 0 None - 1 Crab-eating macaque 5.5 pIC50 = 5.5 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 459 6 1 5 3.1 CN1CCC2(CCN(C(=O)CCNC(=O)c3nc4ccccc4n3Cc3ccccc3)CC2)C1 10.1016/j.bmcl.2008.08.014
11620980 180491 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assay
ChEMBL 554 8 3 6 3.4 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1ccccc1C(F)(F)F 10.1016/j.bmcl.2008.07.108
CHEMBL453596 180491 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assay
ChEMBL 554 8 3 6 3.4 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1ccccc1C(F)(F)F 10.1016/j.bmcl.2008.07.108
23631902 168643 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 530 7 3 5 4.5 O=C(Nc1[nH]nc(C(=O)NCCC2CCN(c3ccncc3)CC2)c1Br)c1ccccc1Cl 10.1021/jm051292n
CHEMBL414892 168643 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 530 7 3 5 4.5 O=C(Nc1[nH]nc(C(=O)NCCC2CCN(c3ccncc3)CC2)c1Br)c1ccccc1Cl 10.1021/jm051292n
11215677 68958 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 614 7 2 6 4.6 O=C(CC1C(=O)NCCN1S(=O)(=O)c1cc2cc(Cl)ccc2s1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2011.03.115
CHEMBL1777957 68958 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 614 7 2 6 4.6 O=C(CC1C(=O)NCCN1S(=O)(=O)c1cc2cc(Cl)ccc2s1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2011.03.115
11561240 76837 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 439 5 2 4 2.5 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3ccccc32)cc1 10.1016/j.bmcl.2011.11.112
CHEMBL1939761 76837 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 439 5 2 4 2.5 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3ccccc32)cc1 10.1016/j.bmcl.2011.11.112
16108961 7710 0 None 2 3 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 583 9 2 5 5.9 O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 10.1021/jm070055c
664 7710 0 None 2 3 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 583 9 2 5 5.9 O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 10.1021/jm070055c
CHEMBL415848 7710 0 None 2 3 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 583 9 2 5 5.9 O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 10.1021/jm070055c
16108961 7710 0 None 2 3 Human 8.5 pIC50 = 8.5 Functional
Antagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilizationAntagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilization
ChEMBL 583 9 2 5 5.9 O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 10.1021/jm061224g
664 7710 0 None 2 3 Human 8.5 pIC50 = 8.5 Functional
Antagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilizationAntagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilization
ChEMBL 583 9 2 5 5.9 O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 10.1021/jm061224g
CHEMBL415848 7710 0 None 2 3 Human 8.5 pIC50 = 8.5 Functional
Antagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilizationAntagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilization
ChEMBL 583 9 2 5 5.9 O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 10.1021/jm061224g
60142705 132697 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 536 6 2 8 4.3 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)c3nnc(C)o3)CC2)no1 nan
CHEMBL3648479 132697 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 536 6 2 8 4.3 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)c3nnc(C)o3)CC2)no1 nan
46230354 208242 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilization
ChEMBL 541 8 3 9 5.2 COc1cc(C(=O)Nc2c[nH]nc2NCc2ccc(-c3cc(Cl)cc(F)c3-c3noc(C)n3)cc2F)on1 10.1016/j.bmcl.2009.11.120
CHEMBL604999 208242 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilization
ChEMBL 541 8 3 9 5.2 COc1cc(C(=O)Nc2c[nH]nc2NCc2ccc(-c3cc(Cl)cc(F)c3-c3noc(C)n3)cc2F)on1 10.1016/j.bmcl.2009.11.120
23630919 149336 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 606 8 2 6 6.0 O=C(Nc1c(Br)c(C(=O)NCCC2CCN(c3ccncc3)CC2)nn1-c1ccccc1)c1ccccc1Cl 10.1021/jm051292n
CHEMBL389097 149336 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 606 8 2 6 6.0 O=C(Nc1c(Br)c(C(=O)NCCC2CCN(c3ccncc3)CC2)nn1-c1ccccc1)c1ccccc1Cl 10.1021/jm051292n
23631902 168643 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at human bradykinin B1 receptor in human MR5 cells assessed as [3H]inositol phosphate accumulationAntagonist activity at human bradykinin B1 receptor in human MR5 cells assessed as [3H]inositol phosphate accumulation
ChEMBL 530 7 3 5 4.5 O=C(Nc1[nH]nc(C(=O)NCCC2CCN(c3ccncc3)CC2)c1Br)c1ccccc1Cl 10.1021/jm1000776
CHEMBL414892 168643 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at human bradykinin B1 receptor in human MR5 cells assessed as [3H]inositol phosphate accumulationAntagonist activity at human bradykinin B1 receptor in human MR5 cells assessed as [3H]inositol phosphate accumulation
ChEMBL 530 7 3 5 4.5 O=C(Nc1[nH]nc(C(=O)NCCC2CCN(c3ccncc3)CC2)c1Br)c1ccccc1Cl 10.1021/jm1000776
46230889 207273 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 419 4 2 6 4.3 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)N(C)O)c(C)c2)no1 10.1016/j.bmcl.2009.11.121
CHEMBL598665 207273 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 419 4 2 6 4.3 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)N(C)O)c(C)c2)no1 10.1016/j.bmcl.2009.11.121
54581664 68961 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 538 7 2 5 3.1 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
CHEMBL1777960 68961 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 538 7 2 5 3.1 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
60142439 132688 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 524 5 2 7 3.1 Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)OCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)n1 nan
CHEMBL3648470 132688 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 524 5 2 7 3.1 Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)OCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)n1 nan
60142837 132704 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 527 5 2 7 5.1 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)OC(C)(C)C)CC2)no1 nan
CHEMBL3648486 132704 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 527 5 2 7 5.1 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)OC(C)(C)C)CC2)no1 nan
11225601 148805 0 None -3 2 Rabbit 8.4 pIC50 = 8.4 Functional
Activity at rabbit bradykinin B1 receptor assessed by FLIPR assayActivity at rabbit bradykinin B1 receptor assessed by FLIPR assay
ChEMBL 490 7 2 8 4.8 C[C@@H](Nc1nccc(Cl)c1NC(=O)CC#N)c1ccc(-c2cccc(F)c2-c2nnn(C)n2)cc1 10.1021/jm049394l
CHEMBL387638 148805 0 None -3 2 Rabbit 8.4 pIC50 = 8.4 Functional
Activity at rabbit bradykinin B1 receptor assessed by FLIPR assayActivity at rabbit bradykinin B1 receptor assessed by FLIPR assay
ChEMBL 490 7 2 8 4.8 C[C@@H](Nc1nccc(Cl)c1NC(=O)CC#N)c1ccc(-c2cccc(F)c2-c2nnn(C)n2)cc1 10.1021/jm049394l
46230989 206968 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 477 5 2 7 4.1 Cn1nnc(-c2c(F)cc(Cl)cc2-c2cnc(CNC(=O)N(O)C3CCCCC3)c(F)c2)n1 10.1016/j.bmcl.2009.11.121
CHEMBL596623 206968 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 477 5 2 7 4.1 Cn1nnc(-c2c(F)cc(Cl)cc2-c2cnc(CNC(=O)N(O)C3CCCCC3)c(F)c2)n1 10.1016/j.bmcl.2009.11.121
11433587 21995 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium flux
ChEMBL 627 10 3 5 5.4 C=C(CN1CC[C@H](O)C1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2010.06.010
CHEMBL1210745 21995 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium flux
ChEMBL 627 10 3 5 5.4 C=C(CN1CC[C@H](O)C1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2010.06.010
23630511 151553 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 486 7 3 5 4.4 O=C(Nc1[nH]nc(C(=O)NCCC2CCN(c3ccncc3)CC2)c1Cl)c1ccccc1Cl 10.1021/jm051292n
CHEMBL390916 151553 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 486 7 3 5 4.4 O=C(Nc1[nH]nc(C(=O)NCCC2CCN(c3ccncc3)CC2)c1Cl)c1ccccc1Cl 10.1021/jm051292n
56835162 76339 0 None -7 2 Rabbit 7.5 pIC50 = 7.5 Functional
Antagonist activity at rabbit B1 bradykinin receptor expressed in CHO cellsAntagonist activity at rabbit B1 bradykinin receptor expressed in CHO cells
ChEMBL 526 5 1 4 6.9 O=C(N[C@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3cccc(Cl)c3c2=O)cc1 10.1016/j.bmcl.2011.10.068
CHEMBL1934260 76339 0 None -7 2 Rabbit 7.5 pIC50 = 7.5 Functional
Antagonist activity at rabbit B1 bradykinin receptor expressed in CHO cellsAntagonist activity at rabbit B1 bradykinin receptor expressed in CHO cells
ChEMBL 526 5 1 4 6.9 O=C(N[C@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3cccc(Cl)c3c2=O)cc1 10.1016/j.bmcl.2011.10.068
11519239 192539 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assay
ChEMBL 520 8 2 5 4.5 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@@H](O)CCS(=O)(=O)c1ccc2ccccc2c1 10.1016/j.bmcl.2008.07.108
CHEMBL486640 192539 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assay
ChEMBL 520 8 2 5 4.5 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@@H](O)CCS(=O)(=O)c1ccc2ccccc2c1 10.1016/j.bmcl.2008.07.108
60142961 132705 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 427 4 2 6 3.5 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(N)CC2)no1 nan
CHEMBL3648487 132705 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 427 4 2 6 3.5 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(N)CC2)no1 nan
CHEMBL3038096 217709 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
In vitro Bradykinin receptor B1 antagonist activity in functional tissue within rabbit aortaIn vitro Bradykinin receptor B1 antagonist activity in functional tissue within rabbit aorta
ChEMBL None None None NC(N)=NCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N[C@H](Cc1ccccc1)C(=O)N(CC(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C1CCCCC1 10.1021/jm950716i
16108966 91154 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilizationAntagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilization
ChEMBL 555 10 2 4 6.1 C[C@@H](NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)c1ccc(CN2CCCCC2)cc1 10.1021/jm061224g
CHEMBL221925 91154 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilizationAntagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilization
ChEMBL 555 10 2 4 6.1 C[C@@H](NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)c1ccc(CN2CCCCC2)cc1 10.1021/jm061224g
46230836 206044 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 389 4 2 6 3.5 Cc1nc(-c2c(F)cccc2-c2cnc([C@@H](C)NC(=O)N(C)O)c(F)c2)no1 10.1016/j.bmcl.2009.11.121
CHEMBL590153 206044 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 389 4 2 6 3.5 Cc1nc(-c2c(F)cccc2-c2cnc([C@@H](C)NC(=O)N(C)O)c(F)c2)no1 10.1016/j.bmcl.2009.11.121
11203826 146900 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Inhibition of human B1 receptor by calcium influx functional assayInhibition of human B1 receptor by calcium influx functional assay
ChEMBL 563 9 2 4 5.3 O=C(C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCCc2cc(CNCC3CC3)ccc21 10.1016/j.bmcl.2006.01.069
CHEMBL380117 146900 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Inhibition of human B1 receptor by calcium influx functional assayInhibition of human B1 receptor by calcium influx functional assay
ChEMBL 563 9 2 4 5.3 O=C(C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCCc2cc(CNCC3CC3)ccc21 10.1016/j.bmcl.2006.01.069
56594770 72502 0 None -7 2 Rabbit 7.5 pIC50 = 7.5 Functional
Inhibition of rabbit B1 receptor by cellular calcium flux assayInhibition of rabbit B1 receptor by cellular calcium flux assay
ChEMBL 541 5 1 6 5.5 Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)nc2)c(=O)c2c(Cl)cccc12 10.1021/jm200808v
CHEMBL1834620 72502 0 None -7 2 Rabbit 7.5 pIC50 = 7.5 Functional
Inhibition of rabbit B1 receptor by cellular calcium flux assayInhibition of rabbit B1 receptor by cellular calcium flux assay
ChEMBL 541 5 1 6 5.5 Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)nc2)c(=O)c2c(Cl)cccc12 10.1021/jm200808v
24946265 193843 0 None 1 2 Crab-eating macaque 6.5 pIC50 = 6.5 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 454 6 1 6 2.6 O=C(NCC(=O)N1CCN(c2ccncc2)CC1)c1nc2ccccc2n1Cc1ccccc1 10.1016/j.bmcl.2008.08.014
CHEMBL491219 193843 0 None 1 2 Crab-eating macaque 6.5 pIC50 = 6.5 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 454 6 1 6 2.6 O=C(NCC(=O)N1CCN(c2ccncc2)CC1)c1nc2ccccc2n1Cc1ccccc1 10.1016/j.bmcl.2008.08.014
42605727 206187 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 409 8 2 5 2.1 CCN(CC)C(=O)c1ccc([C@@H](C)NC(=O)C2(NC(=O)c3cncnc3)CC2)cc1 10.1016/j.bmcl.2009.11.119
CHEMBL591111 206187 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 409 8 2 5 2.1 CCN(CC)C(=O)c1ccc([C@@H](C)NC(=O)C2(NC(=O)c3cncnc3)CC2)cc1 10.1016/j.bmcl.2009.11.119
57399885 76858 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 405 5 2 4 2.0 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)NC2CCC(C)CC2)cc1 10.1016/j.bmcl.2011.11.112
CHEMBL1939923 76858 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 405 5 2 4 2.0 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)NC2CCC(C)CC2)cc1 10.1016/j.bmcl.2011.11.112
49863227 21991 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium flux
ChEMBL 627 10 2 4 6.9 CC(CN1CCCCC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2010.06.010
CHEMBL1210741 21991 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium flux
ChEMBL 627 10 2 4 6.9 CC(CN1CCCCC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2010.06.010
46230890 208039 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 408 4 2 5 4.2 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc(CNC(=O)N(C)O)c(F)c2)no1 10.1016/j.bmcl.2009.11.121
CHEMBL603894 208039 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 408 4 2 5 4.2 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc(CNC(=O)N(C)O)c(F)c2)no1 10.1016/j.bmcl.2009.11.121
49863232 21999 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium flux
ChEMBL 601 12 4 5 4.9 C=C(CNCCO)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2010.06.010
CHEMBL1210749 21999 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium flux
ChEMBL 601 12 4 5 4.9 C=C(CNCCO)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2010.06.010
23631015 99732 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 626 8 2 6 5.5 CN1CCC(N2CCC(CCNC(=O)c3nn(-c4ccccc4)c(NC(=O)c4ccccc4Cl)c3Br)CC2)CC1 10.1021/jm051292n
CHEMBL244124 99732 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 626 8 2 6 5.5 CN1CCC(N2CCC(CCNC(=O)c3nn(-c4ccccc4)c(NC(=O)c4ccccc4Cl)c3Br)CC2)CC1 10.1021/jm051292n
2818985 99972 5 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 431 3 2 2 6.0 CC(C)(C)c1ccc(-c2n[nH]c(NC(=O)c3ccccc3Cl)c2Br)cc1 10.1021/jm051292n
CHEMBL244522 99972 5 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 431 3 2 2 6.0 CC(C)(C)c1ccc(-c2n[nH]c(NC(=O)c3ccccc3Cl)c2Br)cc1 10.1021/jm051292n
44579913 190950 0 None - 1 Crab-eating macaque 5.5 pIC50 = 5.5 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 514 5 0 6 2.9 CN1CCC(N2CCN(C(=O)[C@H]3CCCN3C(=O)c3nc4ccccc4n3Cc3ccccc3)CC2)CC1 10.1016/j.bmcl.2008.08.014
CHEMBL483036 190950 0 None - 1 Crab-eating macaque 5.5 pIC50 = 5.5 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 514 5 0 6 2.9 CN1CCC(N2CCN(C(=O)[C@H]3CCCN3C(=O)c3nc4ccccc4n3Cc3ccccc3)CC2)CC1 10.1016/j.bmcl.2008.08.014
44419046 105050 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilizationAntagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilization
ChEMBL 595 10 2 4 6.0 O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)NC1CCc2cc(CCN3CCCCC3)ccc2C1 10.1021/jm061224g
CHEMBL274624 105050 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilizationAntagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilization
ChEMBL 595 10 2 4 6.0 O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)NC1CCc2cc(CCN3CCCCC3)ccc2C1 10.1021/jm061224g
659 9673 17 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at human bradykinin B1 receptor in human MR5 cells assessed as [3H]inositol phosphate accumulationAntagonist activity at human bradykinin B1 receptor in human MR5 cells assessed as [3H]inositol phosphate accumulation
ChEMBL 659 9 1 7 3.6 CN1CCN(CC1)C(=O)C1CCN(CC1)S(=O)(=O)c1ccc(c(c1)C(=O)N1CCOCC1)NCC(c1ccccc1)c1ccccc1 10.1021/jm1000776
9831083 9673 17 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at human bradykinin B1 receptor in human MR5 cells assessed as [3H]inositol phosphate accumulationAntagonist activity at human bradykinin B1 receptor in human MR5 cells assessed as [3H]inositol phosphate accumulation
ChEMBL 659 9 1 7 3.6 CN1CCN(CC1)C(=O)C1CCN(CC1)S(=O)(=O)c1ccc(c(c1)C(=O)N1CCOCC1)NCC(c1ccccc1)c1ccccc1 10.1021/jm1000776
CHEMBL273869 9673 17 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at human bradykinin B1 receptor in human MR5 cells assessed as [3H]inositol phosphate accumulationAntagonist activity at human bradykinin B1 receptor in human MR5 cells assessed as [3H]inositol phosphate accumulation
ChEMBL 659 9 1 7 3.6 CN1CCN(CC1)C(=O)C1CCN(CC1)S(=O)(=O)c1ccc(c(c1)C(=O)N1CCOCC1)NCC(c1ccccc1)c1ccccc1 10.1021/jm1000776
44579968 199903 0 None - 1 Crab-eating macaque 6.5 pIC50 = 6.5 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 490 8 1 6 3.9 CN(Cc1ccc(-c2ncccn2)cc1)C(=O)CNC(=O)c1nc2ccccc2n1Cc1ccccc1 10.1016/j.bmcl.2008.08.014
CHEMBL522789 199903 0 None - 1 Crab-eating macaque 6.5 pIC50 = 6.5 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 490 8 1 6 3.9 CN(Cc1ccc(-c2ncccn2)cc1)C(=O)CNC(=O)c1nc2ccccc2n1Cc1ccccc1 10.1016/j.bmcl.2008.08.014
16220989 149277 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 589 9 3 5 5.6 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(C(F)(F)F)cc1)c1ccccc1 10.1021/jm070055c
CHEMBL389054 149277 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 589 9 3 5 5.6 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(C(F)(F)F)cc1)c1ccccc1 10.1021/jm070055c
60142568 132691 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 526 5 2 6 5.7 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)OC(C)(C)C)CC2)no1 nan
CHEMBL3648473 132691 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 526 5 2 6 5.7 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)OC(C)(C)C)CC2)no1 nan
56594373 72657 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human B1 bradykinin receptor expressed in CHO cells by aqueorin-based calcium flux assayAntagonist activity at human B1 bradykinin receptor expressed in CHO cells by aqueorin-based calcium flux assay
ChEMBL 506 5 1 5 5.5 Cc1nn(-c2cccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)c2)c(=O)c2ccccc12 10.1016/j.bmcl.2011.10.068
CHEMBL1835762 72657 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human B1 bradykinin receptor expressed in CHO cells by aqueorin-based calcium flux assayAntagonist activity at human B1 bradykinin receptor expressed in CHO cells by aqueorin-based calcium flux assay
ChEMBL 506 5 1 5 5.5 Cc1nn(-c2cccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)c2)c(=O)c2ccccc12 10.1016/j.bmcl.2011.10.068
56594771 72554 0 None -2 2 Rabbit 6.5 pIC50 = 6.5 Functional
Inhibition of rabbit B1 receptor by cellular calcium flux assayInhibition of rabbit B1 receptor by cellular calcium flux assay
ChEMBL 507 5 1 6 4.9 Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2cccnc12 10.1021/jm200808v
CHEMBL1834749 72554 0 None -2 2 Rabbit 6.5 pIC50 = 6.5 Functional
Inhibition of rabbit B1 receptor by cellular calcium flux assayInhibition of rabbit B1 receptor by cellular calcium flux assay
ChEMBL 507 5 1 6 4.9 Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2cccnc12 10.1021/jm200808v
44579652 193956 0 None -57 2 Rat 6.5 pIC50 = 6.5 Functional
Antagonist activity at rat bradykinin B1 receptorAntagonist activity at rat bradykinin B1 receptor
ChEMBL 508 9 1 6 3.6 CCN(CC(=O)N(C)Cc1ccc(C2=NCCN2)cc1)C(=O)c1nc2ccccc2n1Cc1ccccc1 10.1016/j.bmcl.2008.08.014
CHEMBL492211 193956 0 None -57 2 Rat 6.5 pIC50 = 6.5 Functional
Antagonist activity at rat bradykinin B1 receptorAntagonist activity at rat bradykinin B1 receptor
ChEMBL 508 9 1 6 3.6 CCN(CC(=O)N(C)Cc1ccc(C2=NCCN2)cc1)C(=O)c1nc2ccccc2n1Cc1ccccc1 10.1016/j.bmcl.2008.08.014
60142963 132707 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 533 6 2 8 3.8 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)c3ccnnc3)CC2)no1 nan
CHEMBL3648489 132707 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 533 6 2 8 3.8 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)c3ccnnc3)CC2)no1 nan
46230308 208365 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilization
ChEMBL 393 5 2 4 4.9 COC(=O)c1c(F)cccc1-c1ccc(CNc2nc3ccccc3[nH]2)c(F)c1 10.1016/j.bmcl.2009.11.120
CHEMBL605634 208365 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilization
ChEMBL 393 5 2 4 4.9 COC(=O)c1c(F)cccc1-c1ccc(CNc2nc3ccccc3[nH]2)c(F)c1 10.1016/j.bmcl.2009.11.120
46230259 207254 0 None - 1 Human 4.5 pIC50 = 4.5 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilization
ChEMBL 319 4 1 3 3.1 COC(=O)c1c(F)cccc1-c1ccc(CNC(C)=O)c(F)c1 10.1016/j.bmcl.2009.11.120
CHEMBL598552 207254 0 None - 1 Human 4.5 pIC50 = 4.5 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilization
ChEMBL 319 4 1 3 3.1 COC(=O)c1c(F)cccc1-c1ccc(CNC(C)=O)c(F)c1 10.1016/j.bmcl.2009.11.120
16220913 92326 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 515 8 3 5 4.3 NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 10.1021/jm070055c
CHEMBL227828 92326 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 515 8 3 5 4.3 NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 10.1021/jm070055c
44579829 193771 0 None 1 2 Crab-eating macaque 6.5 pIC50 = 6.5 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 496 8 0 6 3.7 CCCN(CC(=O)N1CCN(c2ccncc2)CC1)C(=O)c1nc2ccccc2n1Cc1ccccc1 10.1016/j.bmcl.2008.08.014
CHEMBL490618 193771 0 None 1 2 Crab-eating macaque 6.5 pIC50 = 6.5 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 496 8 0 6 3.7 CCCN(CC(=O)N1CCN(c2ccncc2)CC1)C(=O)c1nc2ccccc2n1Cc1ccccc1 10.1016/j.bmcl.2008.08.014
16108967 91119 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilizationAntagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilization
ChEMBL 541 10 2 4 5.6 O=C(CC(NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)NCc1ccc(CN2CCCCC2)cc1 10.1021/jm061224g
CHEMBL221691 91119 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilizationAntagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilization
ChEMBL 541 10 2 4 5.6 O=C(CC(NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)NCc1ccc(CN2CCCCC2)cc1 10.1021/jm061224g
57395451 76842 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 469 6 2 5 2.5 COc1cccc2c1CCCC2NC(=O)C[C@@H]1C(=O)NC=CN1S(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.11.112
CHEMBL1939766 76842 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 469 6 2 5 2.5 COc1cccc2c1CCCC2NC(=O)C[C@@H]1C(=O)NC=CN1S(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.11.112
57394687 76884 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 494 5 1 5 2.4 Cc1cc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N2CCC[C@H](N3CCCC3)C2)c(C)cc1Cl 10.1016/j.bmcl.2011.11.112
CHEMBL1939949 76884 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 494 5 1 5 2.4 Cc1cc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N2CCC[C@H](N3CCCC3)C2)c(C)cc1Cl 10.1016/j.bmcl.2011.11.112
CHEMBL3038105 217717 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
In vitro Bradykinin receptor B1 antagonist activity in functional tissue within rabbit aortaIn vitro Bradykinin receptor B1 antagonist activity in functional tissue within rabbit aorta
ChEMBL None None None NC(N)=NCCC[C@@H](N)C(=O)N[C@@H](CCCNC(N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N(CC(=O)N1C2CCCCC2C[C@H]1C(=O)O)Cc1ccccc1 10.1021/jm950716i
11555433 195768 0 None 2 2 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assay
ChEMBL 520 8 3 6 3.0 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1cccc(Cl)c1 10.1016/j.bmcl.2008.07.108
CHEMBL508632 195768 0 None 2 2 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assay
ChEMBL 520 8 3 6 3.0 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1cccc(Cl)c1 10.1016/j.bmcl.2008.07.108
57403174 76335 0 None -5 2 Rabbit 6.4 pIC50 = 6.4 Functional
Antagonist activity at rabbit B1 bradykinin receptor expressed in CHO cellsAntagonist activity at rabbit B1 bradykinin receptor expressed in CHO cells
ChEMBL 510 5 1 4 6.4 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3ccc(F)cc3c2=O)c1 10.1016/j.bmcl.2011.10.068
CHEMBL1934256 76335 0 None -5 2 Rabbit 6.4 pIC50 = 6.4 Functional
Antagonist activity at rabbit B1 bradykinin receptor expressed in CHO cellsAntagonist activity at rabbit B1 bradykinin receptor expressed in CHO cells
ChEMBL 510 5 1 4 6.4 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3ccc(F)cc3c2=O)c1 10.1016/j.bmcl.2011.10.068
44579829 193771 0 None -1 2 Rat 6.4 pIC50 = 6.4 Functional
Antagonist activity at rat bradykinin B1 receptorAntagonist activity at rat bradykinin B1 receptor
ChEMBL 496 8 0 6 3.7 CCCN(CC(=O)N1CCN(c2ccncc2)CC1)C(=O)c1nc2ccccc2n1Cc1ccccc1 10.1016/j.bmcl.2008.08.014
CHEMBL490618 193771 0 None -1 2 Rat 6.4 pIC50 = 6.4 Functional
Antagonist activity at rat bradykinin B1 receptorAntagonist activity at rat bradykinin B1 receptor
ChEMBL 496 8 0 6 3.7 CCCN(CC(=O)N1CCN(c2ccncc2)CC1)C(=O)c1nc2ccccc2n1Cc1ccccc1 10.1016/j.bmcl.2008.08.014
56835162 76339 0 None 7 2 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at human B1 bradykinin receptor expressed in CHO cells by aqueorin-based calcium flux assayAntagonist activity at human B1 bradykinin receptor expressed in CHO cells by aqueorin-based calcium flux assay
ChEMBL 526 5 1 4 6.9 O=C(N[C@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3cccc(Cl)c3c2=O)cc1 10.1016/j.bmcl.2011.10.068
CHEMBL1934260 76339 0 None 7 2 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at human B1 bradykinin receptor expressed in CHO cells by aqueorin-based calcium flux assayAntagonist activity at human B1 bradykinin receptor expressed in CHO cells by aqueorin-based calcium flux assay
ChEMBL 526 5 1 4 6.9 O=C(N[C@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3cccc(Cl)c3c2=O)cc1 10.1016/j.bmcl.2011.10.068
56594770 72502 0 None 7 2 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at human B1 receptor expressed in CHO cells by aequorin-based calcium flux assayAntagonist activity at human B1 receptor expressed in CHO cells by aequorin-based calcium flux assay
ChEMBL 541 5 1 6 5.5 Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)nc2)c(=O)c2c(Cl)cccc12 10.1021/jm200808v
CHEMBL1834620 72502 0 None 7 2 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at human B1 receptor expressed in CHO cells by aequorin-based calcium flux assayAntagonist activity at human B1 receptor expressed in CHO cells by aequorin-based calcium flux assay
ChEMBL 541 5 1 6 5.5 Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)nc2)c(=O)c2c(Cl)cccc12 10.1021/jm200808v
11663809 180380 0 None 5 2 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assay
ChEMBL 536 8 3 6 3.5 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1ccc2ccccc2c1 10.1016/j.bmcl.2008.07.108
CHEMBL453339 180380 0 None 5 2 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assay
ChEMBL 536 8 3 6 3.5 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1ccc2ccccc2c1 10.1016/j.bmcl.2008.07.108
16108961 7710 0 None -2 3 Rat 8.4 pIC50 = 8.4 Functional
Antagonistic activity at rat bradykinin B1 receptor assessed as effect on DAK-mediated calcium mobilizationAntagonistic activity at rat bradykinin B1 receptor assessed as effect on DAK-mediated calcium mobilization
ChEMBL 583 9 2 5 5.9 O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 10.1021/jm061224g
664 7710 0 None -2 3 Rat 8.4 pIC50 = 8.4 Functional
Antagonistic activity at rat bradykinin B1 receptor assessed as effect on DAK-mediated calcium mobilizationAntagonistic activity at rat bradykinin B1 receptor assessed as effect on DAK-mediated calcium mobilization
ChEMBL 583 9 2 5 5.9 O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 10.1021/jm061224g
CHEMBL415848 7710 0 None -2 3 Rat 8.4 pIC50 = 8.4 Functional
Antagonistic activity at rat bradykinin B1 receptor assessed as effect on DAK-mediated calcium mobilizationAntagonistic activity at rat bradykinin B1 receptor assessed as effect on DAK-mediated calcium mobilization
ChEMBL 583 9 2 5 5.9 O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 10.1021/jm061224g
60142302 132679 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 536 5 2 5 5.2 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CCCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 nan
CHEMBL3648461 132679 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 536 5 2 5 5.2 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CCCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 nan
60141039 132713 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 553 7 2 9 4.0 COc1cc(C(=O)NC2(C(=O)NC3COc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)ccc43)CC2)on1 nan
CHEMBL3648495 132713 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 553 7 2 9 4.0 COc1cc(C(=O)NC2(C(=O)NC3COc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)ccc43)CC2)on1 nan
53248885 68959 0 None -18 2 Rabbit 8.4 pIC50 = 8.4 Functional
Inhibition of rabbit B1 receptor by cellular calcium flux assayInhibition of rabbit B1 receptor by cellular calcium flux assay
ChEMBL 538 7 2 5 3.1 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1021/jm200808v
CHEMBL1777958 68959 0 None -18 2 Rabbit 8.4 pIC50 = 8.4 Functional
Inhibition of rabbit B1 receptor by cellular calcium flux assayInhibition of rabbit B1 receptor by cellular calcium flux assay
ChEMBL 538 7 2 5 3.1 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1021/jm200808v
54582656 68975 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 510 8 3 5 2.3 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC4CC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
CHEMBL1777974 68975 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 510 8 3 5 2.3 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC4CC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
11635365 181340 0 None 2 2 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assay
ChEMBL 554 8 3 6 3.4 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2008.07.108
CHEMBL455642 181340 0 None 2 2 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assay
ChEMBL 554 8 3 6 3.4 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2008.07.108
60141181 132716 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 551 6 2 8 4.1 Cc1cc(C(=O)NC2(C(=O)N[C@H]3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)ccc43)COC2)on1 nan
CHEMBL3648498 132716 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 551 6 2 8 4.1 Cc1cc(C(=O)NC2(C(=O)N[C@H]3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)ccc43)COC2)on1 nan
46230068 207827 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 527 4 2 4 4.4 C[C@H]1CC[C@@H](C)N1C(=O)c1cnc([C@@H](C)NC(=O)N(C)NC(=O)c2cc(F)cc(C(F)(F)F)c2)c(F)c1 10.1016/j.bmcl.2009.11.119
CHEMBL602555 207827 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 527 4 2 4 4.4 C[C@H]1CC[C@@H](C)N1C(=O)c1cnc([C@@H](C)NC(=O)N(C)NC(=O)c2cc(F)cc(C(F)(F)F)c2)c(F)c1 10.1016/j.bmcl.2009.11.119
44561643 192427 0 None 5 2 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assay
ChEMBL 542 8 3 6 3.7 CC(C)(C)c1ccc(S(=O)(=O)C[C@@H](O)[C@@H](O)C(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2008.07.108
CHEMBL486456 192427 0 None 5 2 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assay
ChEMBL 542 8 3 6 3.7 CC(C)(C)c1ccc(S(=O)(=O)C[C@@H](O)[C@@H](O)C(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2008.07.108
60142566 132687 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 524 5 2 6 4.3 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)OCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 nan
CHEMBL3648469 132687 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 524 5 2 6 4.3 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)OCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 nan
46230938 208050 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 423 5 2 7 2.8 CCN(O)C(=O)NCc1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F 10.1016/j.bmcl.2009.11.121
CHEMBL603962 208050 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 423 5 2 7 2.8 CCN(O)C(=O)NCc1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F 10.1016/j.bmcl.2009.11.121
46216744 208360 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilization
ChEMBL 508 6 2 7 5.7 CC(=O)Nn1c(NCc2ccc(-c3cc(Cl)cc(F)c3-c3noc(C)n3)cc2F)nc2ccccc21 10.1016/j.bmcl.2009.11.120
CHEMBL605570 208360 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilization
ChEMBL 508 6 2 7 5.7 CC(=O)Nn1c(NCc2ccc(-c3cc(Cl)cc(F)c3-c3noc(C)n3)cc2F)nc2ccccc21 10.1016/j.bmcl.2009.11.120
60143099 132711 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 534 6 2 8 3.8 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)OCC3NC(=O)C2(NC(=O)c3ccnnc3)CC2)no1 nan
CHEMBL3648493 132711 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 534 6 2 8 3.8 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)OCC3NC(=O)C2(NC(=O)c3ccnnc3)CC2)no1 nan
57394689 76886 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 496 5 1 5 2.6 Cc1cc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N2CCCCC(N(C)C)CC2)c(C)cc1Cl 10.1016/j.bmcl.2011.11.112
CHEMBL1939951 76886 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 496 5 1 5 2.6 Cc1cc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N2CCCCC(N(C)C)CC2)c(C)cc1Cl 10.1016/j.bmcl.2011.11.112
60141327 132725 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 554 6 2 10 3.3 Cc1nnc(C(=O)NC2(C(=O)NC3CSc4cc(-c5cc(Cl)cc(F)c5-c5nnn(C)n5)ccc43)CC2)o1 nan
CHEMBL3648507 132725 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 554 6 2 10 3.3 Cc1nnc(C(=O)NC2(C(=O)NC3CSc4cc(-c5cc(Cl)cc(F)c5-c5nnn(C)n5)ccc43)CC2)o1 nan
57395702 76848 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 453 5 2 5 2.2 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCC(=O)c3ccccc32)cc1 10.1016/j.bmcl.2011.11.112
CHEMBL1939771 76848 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 453 5 2 5 2.2 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCC(=O)c3ccccc32)cc1 10.1016/j.bmcl.2011.11.112
44579889 193394 0 None - 1 Crab-eating macaque 5.4 pIC50 = 5.4 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 528 5 0 6 3.2 CN1CCC(N2CCN(C(=O)C3CCN(C(=O)c4nc5ccccc5n4Cc4ccccc4)CC3)CC2)CC1 10.1016/j.bmcl.2008.08.014
CHEMBL487908 193394 0 None - 1 Crab-eating macaque 5.4 pIC50 = 5.4 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 528 5 0 6 3.2 CN1CCC(N2CCN(C(=O)C3CCN(C(=O)c4nc5ccccc5n4Cc4ccccc4)CC3)CC2)CC1 10.1016/j.bmcl.2008.08.014
137640759 163861 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity against bradykinin B1 receptor in human HeLa cells assessed as inhibition of Des-Arg9-BK-induced increase in intracellular Ca2+ level by Fluro-4 direct calcium dye based fluorescence assayAntagonist activity against bradykinin B1 receptor in human HeLa cells assessed as inhibition of Des-Arg9-BK-induced increase in intracellular Ca2+ level by Fluro-4 direct calcium dye based fluorescence assay
ChEMBL 1756 21 21 23 -5.9 CC(C)C[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](CO)NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 10.1021/acs.jmedchem.6b01011
CHEMBL4074308 163861 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity against bradykinin B1 receptor in human HeLa cells assessed as inhibition of Des-Arg9-BK-induced increase in intracellular Ca2+ level by Fluro-4 direct calcium dye based fluorescence assayAntagonist activity against bradykinin B1 receptor in human HeLa cells assessed as inhibition of Des-Arg9-BK-induced increase in intracellular Ca2+ level by Fluro-4 direct calcium dye based fluorescence assay
ChEMBL 1756 21 21 23 -5.9 CC(C)C[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](CO)NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 10.1021/acs.jmedchem.6b01011
44579967 193802 0 None - 1 Crab-eating macaque 6.4 pIC50 = 6.4 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 489 8 1 5 4.5 CN(Cc1ccc(-c2ccccn2)cc1)C(=O)CNC(=O)c1nc2ccccc2n1Cc1ccccc1 10.1016/j.bmcl.2008.08.014
CHEMBL490827 193802 0 None - 1 Crab-eating macaque 6.4 pIC50 = 6.4 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 489 8 1 5 4.5 CN(Cc1ccc(-c2ccccn2)cc1)C(=O)CNC(=O)c1nc2ccccc2n1Cc1ccccc1 10.1016/j.bmcl.2008.08.014
44579891 198874 0 None - 1 Crab-eating macaque 5.4 pIC50 = 5.4 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 494 5 0 6 3.4 O=C([C@H]1CCCN1C(=O)c1nc2ccccc2n1Cc1ccccc1)N1CCN(c2ccncc2)CC1 10.1016/j.bmcl.2008.08.014
CHEMBL520304 198874 0 None - 1 Crab-eating macaque 5.4 pIC50 = 5.4 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 494 5 0 6 3.4 O=C([C@H]1CCCN1C(=O)c1nc2ccccc2n1Cc1ccccc1)N1CCN(c2ccncc2)CC1 10.1016/j.bmcl.2008.08.014
11331054 21993 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium flux
ChEMBL 625 10 2 4 6.8 C=C(CN1CCCCC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2010.06.010
CHEMBL1210743 21993 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium flux
ChEMBL 625 10 2 4 6.8 C=C(CN1CCCCC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2010.06.010
24946265 193843 0 None -1 2 Rat 6.4 pIC50 = 6.4 Functional
Antagonist activity at rat bradykinin B1 receptorAntagonist activity at rat bradykinin B1 receptor
ChEMBL 454 6 1 6 2.6 O=C(NCC(=O)N1CCN(c2ccncc2)CC1)c1nc2ccccc2n1Cc1ccccc1 10.1016/j.bmcl.2008.08.014
CHEMBL491219 193843 0 None -1 2 Rat 6.4 pIC50 = 6.4 Functional
Antagonist activity at rat bradykinin B1 receptorAntagonist activity at rat bradykinin B1 receptor
ChEMBL 454 6 1 6 2.6 O=C(NCC(=O)N1CCN(c2ccncc2)CC1)c1nc2ccccc2n1Cc1ccccc1 10.1016/j.bmcl.2008.08.014
16108962 148498 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilizationAntagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilization
ChEMBL 583 9 2 5 5.9 O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@H]1CCOc2cc(CN3CCCCC3)ccc21 10.1021/jm061224g
CHEMBL385740 148498 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilizationAntagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilization
ChEMBL 583 9 2 5 5.9 O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@H]1CCOc2cc(CN3CCCCC3)ccc21 10.1021/jm061224g
46911684 22003 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium flux
ChEMBL 599 11 3 4 6.3 C=C(CNC(C)C)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2010.06.010
CHEMBL1210753 22003 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium flux
ChEMBL 599 11 3 4 6.3 C=C(CNC(C)C)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2010.06.010
23627523 80632 0 None - 1 Rat 7.4 pIC50 = 7.4 Functional
Antagonist activity at rat bradykinin B1 receptorAntagonist activity at rat bradykinin B1 receptor
ChEMBL 654 8 2 5 6.3 O=C(CC1c2cc(F)cc(F)c2-c2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)NCCc1ccc(C2=NCCN2)cc1 10.1016/j.bmcl.2012.03.065
CHEMBL2018872 80632 0 None - 1 Rat 7.4 pIC50 = 7.4 Functional
Antagonist activity at rat bradykinin B1 receptorAntagonist activity at rat bradykinin B1 receptor
ChEMBL 654 8 2 5 6.3 O=C(CC1c2cc(F)cc(F)c2-c2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)NCCc1ccc(C2=NCCN2)cc1 10.1016/j.bmcl.2012.03.065
11215189 175572 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Inhibition of human B1 receptor by calcium influx functional assayInhibition of human B1 receptor by calcium influx functional assay
ChEMBL 565 9 2 4 5.6 CC(C)CNCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2006.01.069
CHEMBL437509 175572 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Inhibition of human B1 receptor by calcium influx functional assayInhibition of human B1 receptor by calcium influx functional assay
ChEMBL 565 9 2 4 5.6 CC(C)CNCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2006.01.069
46230306 206985 0 None - 1 Human 4.4 pIC50 = 4.4 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilization
ChEMBL 345 4 0 3 3.5 COC(=O)c1c(F)cccc1-c1ccc(CN2CCCC2=O)c(F)c1 10.1016/j.bmcl.2009.11.120
CHEMBL596718 206985 0 None - 1 Human 4.4 pIC50 = 4.4 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilization
ChEMBL 345 4 0 3 3.5 COC(=O)c1c(F)cccc1-c1ccc(CN2CCCC2=O)c(F)c1 10.1016/j.bmcl.2009.11.120
23627583 80634 0 None - 1 Rat 7.4 pIC50 = 7.4 Functional
Antagonist activity at rat bradykinin B1 receptorAntagonist activity at rat bradykinin B1 receptor
ChEMBL 655 9 1 5 7.5 COc1cccc2c1-c1ccccc1N(S(=O)(=O)c1ccc(Cl)c(Cl)c1)C2CC(=O)N[C@H]1CC[C@H](CCN2CCCC2)CC1 10.1016/j.bmcl.2012.03.065
CHEMBL2018874 80634 0 None - 1 Rat 7.4 pIC50 = 7.4 Functional
Antagonist activity at rat bradykinin B1 receptorAntagonist activity at rat bradykinin B1 receptor
ChEMBL 655 9 1 5 7.5 COc1cccc2c1-c1ccccc1N(S(=O)(=O)c1ccc(Cl)c(Cl)c1)C2CC(=O)N[C@H]1CC[C@H](CCN2CCCC2)CC1 10.1016/j.bmcl.2012.03.065
44410254 82733 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Inhibition of human B1 receptor by calcium influx functional assayInhibition of human B1 receptor by calcium influx functional assay
ChEMBL 548 7 2 5 5.3 CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc2cnccc12 10.1016/j.bmcl.2006.01.069
CHEMBL205242 82733 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Inhibition of human B1 receptor by calcium influx functional assayInhibition of human B1 receptor by calcium influx functional assay
ChEMBL 548 7 2 5 5.3 CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc2cnccc12 10.1016/j.bmcl.2006.01.069
44410020 144998 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Inhibition of human B1 receptor by calcium influx functional assayInhibition of human B1 receptor by calcium influx functional assay
ChEMBL 549 7 1 4 5.0 O=C(C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCCc2cc(CN3CCC3)ccc21 10.1016/j.bmcl.2006.01.069
CHEMBL377011 144998 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Inhibition of human B1 receptor by calcium influx functional assayInhibition of human B1 receptor by calcium influx functional assay
ChEMBL 549 7 1 4 5.0 O=C(C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCCc2cc(CN3CCC3)ccc21 10.1016/j.bmcl.2006.01.069
49863236 22004 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium flux
ChEMBL 611 11 3 4 6.5 C=C(CNC1CCC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2010.06.010
CHEMBL1210754 22004 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium flux
ChEMBL 611 11 3 4 6.5 C=C(CNC1CCC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2010.06.010
23630918 99521 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 544 7 2 6 4.5 Cn1nc(C(=O)NCCC2CCN(c3ccncc3)CC2)c(Br)c1NC(=O)c1ccccc1Cl 10.1021/jm051292n
CHEMBL243650 99521 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 544 7 2 6 4.5 Cn1nc(C(=O)NCCC2CCN(c3ccncc3)CC2)c(Br)c1NC(=O)c1ccccc1Cl 10.1021/jm051292n
11635364 181341 0 None 4 2 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assay
ChEMBL 554 8 3 6 3.4 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1ccc(C(F)(F)F)cc1 10.1016/j.bmcl.2008.07.108
CHEMBL455643 181341 0 None 4 2 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assay
ChEMBL 554 8 3 6 3.4 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1ccc(C(F)(F)F)cc1 10.1016/j.bmcl.2008.07.108
44410250 82730 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Inhibition of human B1 receptor by calcium influx functional assayInhibition of human B1 receptor by calcium influx functional assay
ChEMBL 548 7 2 5 5.3 CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc2cccnc12 10.1016/j.bmcl.2006.01.069
CHEMBL205227 82730 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Inhibition of human B1 receptor by calcium influx functional assayInhibition of human B1 receptor by calcium influx functional assay
ChEMBL 548 7 2 5 5.3 CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc2cccnc12 10.1016/j.bmcl.2006.01.069
16108968 172917 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilizationAntagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilization
ChEMBL 541 10 2 4 5.6 O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)NCc1ccc(CN2CCCCC2)cc1 10.1021/jm061224g
CHEMBL426165 172917 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilizationAntagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilization
ChEMBL 541 10 2 4 5.6 O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)NCc1ccc(CN2CCCCC2)cc1 10.1021/jm061224g
16202227 80631 0 None - 1 Rat 7.4 pIC50 = 7.4 Functional
Antagonist activity at rat bradykinin B1 receptorAntagonist activity at rat bradykinin B1 receptor
ChEMBL 636 8 2 5 6.1 O=C(CC1c2cc(F)ccc2-c2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)NCCc1ccc(C2=NCCN2)cc1 10.1016/j.bmcl.2012.03.065
CHEMBL2018871 80631 0 None - 1 Rat 7.4 pIC50 = 7.4 Functional
Antagonist activity at rat bradykinin B1 receptorAntagonist activity at rat bradykinin B1 receptor
ChEMBL 636 8 2 5 6.1 O=C(CC1c2cc(F)ccc2-c2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)NCCc1ccc(C2=NCCN2)cc1 10.1016/j.bmcl.2012.03.065
16220915 92309 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 557 10 3 5 5.4 CC(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 10.1021/jm070055c
CHEMBL227690 92309 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 557 10 3 5 5.4 CC(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 10.1021/jm070055c
16221108 92306 0 None -22 2 Rabbit 6.4 pIC50 = 6.4 Functional
Antagonist activity at rabbit bradykinin B1 receptorAntagonist activity at rabbit bradykinin B1 receptor
ChEMBL 605 9 2 5 5.5 O=C(C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1)N[C@@H]1CCOc2cc(CN3CCCC3)ccc21 10.1021/jm070055c
CHEMBL227600 92306 0 None -22 2 Rabbit 6.4 pIC50 = 6.4 Functional
Antagonist activity at rabbit bradykinin B1 receptorAntagonist activity at rabbit bradykinin B1 receptor
ChEMBL 605 9 2 5 5.5 O=C(C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1)N[C@@H]1CCOc2cc(CN3CCCC3)ccc21 10.1021/jm070055c
60142165 132673 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 496 5 2 5 3.3 COC(=O)c1c(Cl)cccc1-c1ccc2c(c1)CC[C@@H]2NC(=O)C1(NC(=O)C(F)(F)F)COC1 nan
CHEMBL3648456 132673 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 496 5 2 5 3.3 COC(=O)c1c(Cl)cccc1-c1ccc2c(c1)CC[C@@H]2NC(=O)C1(NC(=O)C(F)(F)F)COC1 nan
CHEMBL3038103 217715 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
In vitro Bradykinin receptor B1 antagonist activity in functional tissue within rabbit aortaIn vitro Bradykinin receptor B1 antagonist activity in functional tissue within rabbit aorta
ChEMBL None None None NC(N)=NCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(=O)N(CC(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C1CCCCC1)C1CCCC1 10.1021/jm950716i
11478613 147369 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Inhibition of human B1 receptor by calcium influx functional assayInhibition of human B1 receptor by calcium influx functional assay
ChEMBL 567 10 2 5 4.6 COCCNCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2006.01.069
CHEMBL381372 147369 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Inhibition of human B1 receptor by calcium influx functional assayInhibition of human B1 receptor by calcium influx functional assay
ChEMBL 567 10 2 5 4.6 COCCNCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2006.01.069
16221229 92343 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 605 10 3 5 5.5 O=C(C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1)N[C@@H]1CCOc2cc(CNC3CCC3)ccc21 10.1021/jm070055c
CHEMBL227977 92343 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 605 10 3 5 5.5 O=C(C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1)N[C@@H]1CCOc2cc(CNC3CCC3)ccc21 10.1021/jm070055c
44579850 193945 0 None - 1 Crab-eating macaque 6.3 pIC50 = 6.3 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 516 7 0 6 3.2 CC(C)N(CC(=O)N1CCN(C2CCN(C)CC2)CC1)C(=O)c1nc2ccccc2n1Cc1ccccc1 10.1016/j.bmcl.2008.08.014
CHEMBL492048 193945 0 None - 1 Crab-eating macaque 6.3 pIC50 = 6.3 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 516 7 0 6 3.2 CC(C)N(CC(=O)N1CCN(C2CCN(C)CC2)CC1)C(=O)c1nc2ccccc2n1Cc1ccccc1 10.1016/j.bmcl.2008.08.014
49863237 22005 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium flux
ChEMBL 625 11 3 4 6.9 C=C(CNC1CCCC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2010.06.010
CHEMBL1210755 22005 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium flux
ChEMBL 625 11 3 4 6.9 C=C(CNC1CCCC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2010.06.010
11330286 83245 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Inhibition of human B1 receptor by calcium influx functional assayInhibition of human B1 receptor by calcium influx functional assay
ChEMBL 549 8 2 4 5.1 O=C(C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCCc2cc(CNC3CC3)ccc21 10.1016/j.bmcl.2006.01.069
CHEMBL205981 83245 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Inhibition of human B1 receptor by calcium influx functional assayInhibition of human B1 receptor by calcium influx functional assay
ChEMBL 549 8 2 4 5.1 O=C(C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCCc2cc(CNC3CC3)ccc21 10.1016/j.bmcl.2006.01.069
60142026 132670 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 480 5 2 4 4.1 COC(=O)c1c(Cl)cccc1-c1ccc2c(c1)CCC2NC(=O)C1(NC(=O)C(F)(F)F)CC1 nan
CHEMBL3648453 132670 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 480 5 2 4 4.1 COC(=O)c1c(Cl)cccc1-c1ccc2c(c1)CCC2NC(=O)C1(NC(=O)C(F)(F)F)CC1 nan
54583583 68946 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 462 6 2 5 1.3 CS(=O)(=O)N1CCNC(=O)C1CC(=O)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2011.03.115
CHEMBL1777880 68946 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 462 6 2 5 1.3 CS(=O)(=O)N1CCNC(=O)C1CC(=O)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2011.03.115
56594241 72651 0 None -4 2 Rabbit 6.3 pIC50 = 6.3 Functional
Antagonist activity at rabbit B1 bradykinin receptor expressed in CHO cellsAntagonist activity at rabbit B1 bradykinin receptor expressed in CHO cells
ChEMBL 492 5 1 4 6.3 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3ccccc3c2=O)c1 10.1016/j.bmcl.2011.10.068
CHEMBL1835756 72651 0 None -4 2 Rabbit 6.3 pIC50 = 6.3 Functional
Antagonist activity at rabbit B1 bradykinin receptor expressed in CHO cellsAntagonist activity at rabbit B1 bradykinin receptor expressed in CHO cells
ChEMBL 492 5 1 4 6.3 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3ccccc3c2=O)c1 10.1016/j.bmcl.2011.10.068
11663606 201358 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assay
ChEMBL 520 8 2 5 4.5 O=C(C[C@H](O)CS(=O)(=O)c1ccc2ccccc2c1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2008.07.108
CHEMBL530554 201358 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assay
ChEMBL 520 8 2 5 4.5 O=C(C[C@H](O)CS(=O)(=O)c1ccc2ccccc2c1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2008.07.108
23630513 150756 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 542 5 4 5 4.0 O=C(Nc1[nH]nc(C(=O)NC2N=C(c3ccccc3)c3ccccc3NC2=O)c1Br)c1ccccc1 10.1021/jm051292n
CHEMBL390272 150756 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 542 5 4 5 4.0 O=C(Nc1[nH]nc(C(=O)NC2N=C(c3ccccc3)c3ccccc3NC2=O)c1Br)c1ccccc1 10.1021/jm051292n
11224694 99541 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 447 6 3 4 3.4 O=C(Nc1[nH]nc(C(=O)NCCc2ccncc2)c1Br)c1ccccc1Cl 10.1021/jm051292n
CHEMBL243667 99541 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 447 6 3 4 3.4 O=C(Nc1[nH]nc(C(=O)NCCc2ccncc2)c1Br)c1ccccc1Cl 10.1021/jm051292n
44579795 193724 0 None 30 2 Crab-eating macaque 8.3 pIC50 = 8.3 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 480 8 2 6 2.8 CN(Cc1ccc(C2=NCCN2)cc1)C(=O)CNC(=O)c1nc2ccccc2n1Cc1ccccc1 10.1016/j.bmcl.2008.08.014
CHEMBL490201 193724 0 None 30 2 Crab-eating macaque 8.3 pIC50 = 8.3 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 480 8 2 6 2.8 CN(Cc1ccc(C2=NCCN2)cc1)C(=O)CNC(=O)c1nc2ccccc2n1Cc1ccccc1 10.1016/j.bmcl.2008.08.014
42606292 206318 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 519 6 2 3 5.0 CC1CCC(C)N1C(=O)c1ccc([C@@H](C)NC(=O)C2(NC(=O)c3cc(F)cc(C(F)(F)F)c3)CC2)cc1 10.1016/j.bmcl.2009.11.119
CHEMBL592238 206318 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 519 6 2 3 5.0 CC1CCC(C)N1C(=O)c1ccc([C@@H](C)NC(=O)C2(NC(=O)c3cc(F)cc(C(F)(F)F)c3)CC2)cc1 10.1016/j.bmcl.2009.11.119
60142569 132692 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 426 4 2 5 4.1 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(N)CC2)no1 nan
CHEMBL3648474 132692 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 426 4 2 5 4.1 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(N)CC2)no1 nan
11478717 99563 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 576 5 4 5 4.6 O=C(Nc1[nH]nc(C(=O)NC2N=C(c3ccccc3)c3ccccc3NC2=O)c1Br)c1ccccc1Cl 10.1021/jm051292n
CHEMBL243679 99563 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 576 5 4 5 4.6 O=C(Nc1[nH]nc(C(=O)NC2N=C(c3ccccc3)c3ccccc3NC2=O)c1Br)c1ccccc1Cl 10.1021/jm051292n
16108969 89806 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assay
ChEMBL 581 9 2 4 6.4 O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2008.07.108
CHEMBL218152 89806 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assay
ChEMBL 581 9 2 4 6.4 O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2008.07.108
16108969 89806 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilizationAntagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilization
ChEMBL 581 9 2 4 6.4 O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1021/jm061224g
CHEMBL218152 89806 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilizationAntagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilization
ChEMBL 581 9 2 4 6.4 O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1021/jm061224g
16108960 176038 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilizationAntagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilization
ChEMBL 567 9 2 4 6.0 O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCc2cc(CN3CCCCC3)ccc21 10.1021/jm061224g
CHEMBL441188 176038 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilizationAntagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilization
ChEMBL 567 9 2 4 6.0 O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCc2cc(CN3CCCCC3)ccc21 10.1021/jm061224g
60141183 132718 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 527 5 2 8 3.9 Cn1nnc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)OC(C)(C)C)CC2)n1 nan
CHEMBL3648500 132718 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 527 5 2 8 3.9 Cn1nnc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)OC(C)(C)C)CC2)n1 nan
11670860 192541 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assay
ChEMBL 520 8 2 5 4.5 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)CCS(=O)(=O)c1ccc2ccccc2c1 10.1016/j.bmcl.2008.07.108
CHEMBL486641 192541 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assay
ChEMBL 520 8 2 5 4.5 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)CCS(=O)(=O)c1ccc2ccccc2c1 10.1016/j.bmcl.2008.07.108
42606173 206188 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 437 8 2 5 2.9 CC(C)N(C(=O)c1ccc([C@@H](C)NC(=O)C2(NC(=O)c3cncnc3)CC2)cc1)C(C)C 10.1016/j.bmcl.2009.11.119
CHEMBL591112 206188 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 437 8 2 5 2.9 CC(C)N(C(=O)c1ccc([C@@H](C)NC(=O)C2(NC(=O)c3cncnc3)CC2)cc1)C(C)C 10.1016/j.bmcl.2009.11.119
16108963 168746 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilizationAntagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilization
ChEMBL 583 9 2 5 5.9 O=C(C[C@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCOc2cc(CN3CCCCC3)ccc21 10.1021/jm061224g
CHEMBL415849 168746 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilizationAntagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilization
ChEMBL 583 9 2 5 5.9 O=C(C[C@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCOc2cc(CN3CCCCC3)ccc21 10.1021/jm061224g
23627458 80629 0 None - 1 Rat 7.3 pIC50 = 7.3 Functional
Antagonist activity at rat bradykinin B1 receptorAntagonist activity at rat bradykinin B1 receptor
ChEMBL 564 8 2 5 5.0 Cc1ccc(S(=O)(=O)N2c3ccccc3-c3ccccc3C2CC(=O)NCCc2ccc(C3=NCCN3)cc2)cc1 10.1016/j.bmcl.2012.03.065
CHEMBL2018869 80629 0 None - 1 Rat 7.3 pIC50 = 7.3 Functional
Antagonist activity at rat bradykinin B1 receptorAntagonist activity at rat bradykinin B1 receptor
ChEMBL 564 8 2 5 5.0 Cc1ccc(S(=O)(=O)N2c3ccccc3-c3ccccc3C2CC(=O)NCCc2ccc(C3=NCCN3)cc2)cc1 10.1016/j.bmcl.2012.03.065
44579849 193679 0 None - 1 Crab-eating macaque 6.3 pIC50 = 6.3 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 438 7 3 5 3.7 O=C(CCNC(=O)c1nc2ccccc2n1Cc1ccccc1)Nc1ccc2cn[nH]c2c1 10.1016/j.bmcl.2008.08.014
CHEMBL489808 193679 0 None - 1 Crab-eating macaque 6.3 pIC50 = 6.3 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 438 7 3 5 3.7 O=C(CCNC(=O)c1nc2ccccc2n1Cc1ccccc1)Nc1ccc2cn[nH]c2c1 10.1016/j.bmcl.2008.08.014
11452874 159168 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 418 4 3 3 4.3 O=C(Nc1[nH]nc(C(=O)Nc2ccccc2)c1Br)c1ccccc1Cl 10.1021/jm051292n
CHEMBL397037 159168 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 418 4 3 3 4.3 O=C(Nc1[nH]nc(C(=O)Nc2ccccc2)c1Br)c1ccccc1Cl 10.1021/jm051292n
44579865 193581 0 None - 1 Crab-eating macaque 7.3 pIC50 = 7.3 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 494 9 2 6 3.2 CN(Cc1ccc(C2=NCCN2)cc1)C(=O)CCNC(=O)c1nc2ccccc2n1Cc1ccccc1 10.1016/j.bmcl.2008.08.014
CHEMBL489203 193581 0 None - 1 Crab-eating macaque 7.3 pIC50 = 7.3 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 494 9 2 6 3.2 CN(Cc1ccc(C2=NCCN2)cc1)C(=O)CCNC(=O)c1nc2ccccc2n1Cc1ccccc1 10.1016/j.bmcl.2008.08.014
11238372 175819 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Inhibition of human B1 receptor by calcium influx functional assayInhibition of human B1 receptor by calcium influx functional assay
ChEMBL 563 8 2 4 5.5 O=C(C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCCc2cc(CNC3CCC3)ccc21 10.1016/j.bmcl.2006.01.069
CHEMBL439505 175819 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Inhibition of human B1 receptor by calcium influx functional assayInhibition of human B1 receptor by calcium influx functional assay
ChEMBL 563 8 2 4 5.5 O=C(C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCCc2cc(CNC3CCC3)ccc21 10.1016/j.bmcl.2006.01.069
44419100 89939 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilizationAntagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilization
ChEMBL 555 11 2 4 5.6 O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)NCCc1ccc(CN2CCCCC2)cc1 10.1021/jm061224g
CHEMBL218314 89939 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilizationAntagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilization
ChEMBL 555 11 2 4 5.6 O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)NCCc1ccc(CN2CCCCC2)cc1 10.1021/jm061224g
44410179 173095 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Inhibition of human B1 receptor by calcium influx functional assayInhibition of human B1 receptor by calcium influx functional assay
ChEMBL 573 8 2 4 6.4 CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2006.01.069
CHEMBL427208 173095 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Inhibition of human B1 receptor by calcium influx functional assayInhibition of human B1 receptor by calcium influx functional assay
ChEMBL 573 8 2 4 6.4 CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2006.01.069
11373520 158840 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 419 4 3 4 3.7 O=C(Nc1[nH]nc(C(=O)Nc2ccncc2)c1Br)c1ccccc1Cl 10.1021/jm051292n
CHEMBL396735 158840 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 419 4 3 4 3.7 O=C(Nc1[nH]nc(C(=O)Nc2ccncc2)c1Br)c1ccccc1Cl 10.1021/jm051292n
16221227 149796 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 614 9 3 6 5.5 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(C#N)cc1 10.1021/jm070055c
CHEMBL389477 149796 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 614 9 3 6 5.5 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(C#N)cc1 10.1021/jm070055c
16221163 92346 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 555 9 3 5 5.3 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(Cl)cc1)c1ccccc1 10.1021/jm070055c
CHEMBL228030 92346 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 555 9 3 5 5.3 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(Cl)cc1)c1ccccc1 10.1021/jm070055c
46230892 207310 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 395 4 3 7 2.1 Cn1nnc(-c2c(F)cc(Cl)cc2-c2cnc(CNC(=O)NO)c(F)c2)n1 10.1016/j.bmcl.2009.11.121
CHEMBL598868 207310 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells assessed as inhibition of des-Arg-bradykinin-mediated calcium mobilization
ChEMBL 395 4 3 7 2.1 Cn1nnc(-c2c(F)cc(Cl)cc2-c2cnc(CNC(=O)NO)c(F)c2)n1 10.1016/j.bmcl.2009.11.121
44410269 172913 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Inhibition of human B1 receptor by calcium influx functional assayInhibition of human B1 receptor by calcium influx functional assay
ChEMBL 569 11 2 5 5.9 CCCCOc1ccc(S(=O)(=O)N2CCCC[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC(C)(C)C)ccc32)cc1 10.1016/j.bmcl.2006.01.069
CHEMBL426130 172913 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Inhibition of human B1 receptor by calcium influx functional assayInhibition of human B1 receptor by calcium influx functional assay
ChEMBL 569 11 2 5 5.9 CCCCOc1ccc(S(=O)(=O)N2CCCC[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC(C)(C)C)ccc32)cc1 10.1016/j.bmcl.2006.01.069
44579652 193956 0 None 57 2 Crab-eating macaque 8.2 pIC50 = 8.2 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 508 9 1 6 3.6 CCN(CC(=O)N(C)Cc1ccc(C2=NCCN2)cc1)C(=O)c1nc2ccccc2n1Cc1ccccc1 10.1016/j.bmcl.2008.08.014
CHEMBL492211 193956 0 None 57 2 Crab-eating macaque 8.2 pIC50 = 8.2 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 508 9 1 6 3.6 CCN(CC(=O)N(C)Cc1ccc(C2=NCCN2)cc1)C(=O)c1nc2ccccc2n1Cc1ccccc1 10.1016/j.bmcl.2008.08.014
44419045 144066 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilizationAntagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilization
ChEMBL 581 9 2 4 6.4 O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)NC1CCCc2cc(CN3CCCCC3)ccc21 10.1021/jm061224g
CHEMBL375229 144066 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilizationAntagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilization
ChEMBL 581 9 2 4 6.4 O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)NC1CCCc2cc(CN3CCCCC3)ccc21 10.1021/jm061224g
23630809 174139 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 451 4 3 4 2.9 O=C(Nc1[nH]nc(C(=O)N[C@@H]2CN3CCC2CC3)c1Br)c1ccccc1Cl 10.1021/jm051292n
CHEMBL429463 174139 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 451 4 3 4 2.9 O=C(Nc1[nH]nc(C(=O)N[C@@H]2CN3CCC2CC3)c1Br)c1ccccc1Cl 10.1021/jm051292n
16221110 91810 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 543 10 3 5 5.0 CCNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 10.1021/jm070055c
CHEMBL224071 91810 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 543 10 3 5 5.0 CCNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 10.1021/jm070055c
16221164 168525 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 577 9 3 5 5.9 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(C(C)(C)C)cc1)c1ccccc1 10.1021/jm070055c
CHEMBL413786 168525 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 577 9 3 5 5.9 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(C(C)(C)C)cc1)c1ccccc1 10.1021/jm070055c
24946267 193773 0 None - 1 Crab-eating macaque 6.2 pIC50 = 6.2 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 488 7 1 6 2.4 CN1CCC(N2CCN(C(=O)CCNC(=O)c3nc4ccccc4n3Cc3ccccc3)CC2)CC1 10.1016/j.bmcl.2008.08.014
CHEMBL490626 193773 0 None - 1 Crab-eating macaque 6.2 pIC50 = 6.2 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 488 7 1 6 2.4 CN1CCC(N2CCN(C(=O)CCNC(=O)c3nc4ccccc4n3Cc3ccccc3)CC2)CC1 10.1016/j.bmcl.2008.08.014
60141184 132719 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 427 4 2 7 2.3 Cn1nnc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(N)CC2)n1 nan
CHEMBL3648501 132719 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 427 4 2 7 2.3 Cn1nnc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(N)CC2)n1 nan
46230307 208004 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilization
ChEMBL 393 4 0 3 4.6 COC(=O)c1c(F)cccc1-c1ccc(CN2Cc3ccccc3C2=O)c(F)c1 10.1016/j.bmcl.2009.11.120
CHEMBL603657 208004 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilization
ChEMBL 393 4 0 3 4.6 COC(=O)c1c(F)cccc1-c1ccc(CN2Cc3ccccc3C2=O)c(F)c1 10.1016/j.bmcl.2009.11.120
44587206 194926 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cellsAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells
ChEMBL 575 6 3 6 4.0 O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)N[C@@H]1CCOc2cc(CO)ccc21 10.1016/j.bmcl.2008.07.055
CHEMBL498488 194926 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cellsAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells
ChEMBL 575 6 3 6 4.0 O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)N[C@@H]1CCOc2cc(CO)ccc21 10.1016/j.bmcl.2008.07.055
44579945 193608 0 None - 1 Crab-eating macaque 6.2 pIC50 = 6.2 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 478 8 1 6 3.7 CN(Cc1ccc(-n2ccnc2)cc1)C(=O)CNC(=O)c1nc2ccccc2n1Cc1ccccc1 10.1016/j.bmcl.2008.08.014
CHEMBL489389 193608 0 None - 1 Crab-eating macaque 6.2 pIC50 = 6.2 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 478 8 1 6 3.7 CN(Cc1ccc(-n2ccnc2)cc1)C(=O)CNC(=O)c1nc2ccccc2n1Cc1ccccc1 10.1016/j.bmcl.2008.08.014
23630612 98857 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 544 7 2 6 4.5 Cn1nc(NC(=O)c2ccccc2Cl)c(Br)c1C(=O)NCCC1CCN(c2ccncc2)CC1 10.1021/jm051292n
CHEMBL241935 98857 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 544 7 2 6 4.5 Cn1nc(NC(=O)c2ccccc2Cl)c(Br)c1C(=O)NCCC1CCN(c2ccncc2)CC1 10.1021/jm051292n
23630814 158882 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 508 5 4 5 3.3 CC(C)C(=O)Nc1[nH]nc(C(=O)NC2N=C(c3ccccc3)c3ccccc3NC2=O)c1Br 10.1021/jm051292n
CHEMBL396771 158882 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 508 5 4 5 3.3 CC(C)C(=O)Nc1[nH]nc(C(=O)NC2N=C(c3ccccc3)c3ccccc3NC2=O)c1Br 10.1021/jm051292n
57399671 76344 0 None 2 2 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at human B1 bradykinin receptor expressed in CHO cells by aqueorin-based calcium flux assayAntagonist activity at human B1 bradykinin receptor expressed in CHO cells by aqueorin-based calcium flux assay
ChEMBL 506 5 1 4 6.6 Cc1cccc2occ(-c3ccc(C(=O)N[C@H]4CCCc5cc(CN6CCCCC6)ccc54)cc3)c(=O)c12 10.1016/j.bmcl.2011.10.068
CHEMBL1934265 76344 0 None 2 2 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at human B1 bradykinin receptor expressed in CHO cells by aqueorin-based calcium flux assayAntagonist activity at human B1 bradykinin receptor expressed in CHO cells by aqueorin-based calcium flux assay
ChEMBL 506 5 1 4 6.6 Cc1cccc2occ(-c3ccc(C(=O)N[C@H]4CCCc5cc(CN6CCCCC6)ccc54)cc3)c(=O)c12 10.1016/j.bmcl.2011.10.068
11444270 83494 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Inhibition of human B1 receptor by calcium influx functional assayInhibition of human B1 receptor by calcium influx functional assay
ChEMBL 553 7 2 5 5.9 CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1csc2ccccc12 10.1016/j.bmcl.2006.01.069
CHEMBL206554 83494 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Inhibition of human B1 receptor by calcium influx functional assayInhibition of human B1 receptor by calcium influx functional assay
ChEMBL 553 7 2 5 5.9 CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1csc2ccccc12 10.1016/j.bmcl.2006.01.069
24755613 199905 0 None - 1 Crab-eating macaque 6.2 pIC50 = 6.2 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 474 6 1 6 2.1 CN1CCC(N2CCN(C(=O)CNC(=O)c3nc4ccccc4n3Cc3ccccc3)CC2)CC1 10.1016/j.bmcl.2008.08.014
CHEMBL522798 199905 0 None - 1 Crab-eating macaque 6.2 pIC50 = 6.2 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 474 6 1 6 2.1 CN1CCC(N2CCN(C(=O)CNC(=O)c3nc4ccccc4n3Cc3ccccc3)CC2)CC1 10.1016/j.bmcl.2008.08.014
16221160 104045 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 597 10 3 5 6.3 O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCOc2cc(CNC3CCCCC3)ccc21 10.1021/jm070055c
CHEMBL268911 104045 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 597 10 3 5 6.3 O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCOc2cc(CNC3CCCCC3)ccc21 10.1021/jm070055c
57399670 76332 0 None 13 2 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at human B1 bradykinin receptor expressed in CHO cells by aqueorin-based calcium flux assayAntagonist activity at human B1 bradykinin receptor expressed in CHO cells by aqueorin-based calcium flux assay
ChEMBL 506 5 1 5 5.5 Cc1nn(-c2ccc(C(=O)N[C@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2ccccc12 10.1016/j.bmcl.2011.10.068
CHEMBL1934253 76332 0 None 13 2 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at human B1 bradykinin receptor expressed in CHO cells by aqueorin-based calcium flux assayAntagonist activity at human B1 bradykinin receptor expressed in CHO cells by aqueorin-based calcium flux assay
ChEMBL 506 5 1 5 5.5 Cc1nn(-c2ccc(C(=O)N[C@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2ccccc12 10.1016/j.bmcl.2011.10.068
11386138 91216 0 None -8 2 Rabbit 8.1 pIC50 = 8.1 Functional
Activity at rabbit bradykinin B1 receptor assessed by FLIPR assayActivity at rabbit bradykinin B1 receptor assessed by FLIPR assay
ChEMBL 482 7 2 6 5.9 COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)Nc2nccc(Cl)c2NC(=O)CC#N)cc1 10.1021/jm049394l
CHEMBL221998 91216 0 None -8 2 Rabbit 8.1 pIC50 = 8.1 Functional
Activity at rabbit bradykinin B1 receptor assessed by FLIPR assayActivity at rabbit bradykinin B1 receptor assessed by FLIPR assay
ChEMBL 482 7 2 6 5.9 COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)Nc2nccc(Cl)c2NC(=O)CC#N)cc1 10.1021/jm049394l
16102899 91121 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Activity at human bradykinin B1 receptor assessed as inhibition of Des-arg kallidin-induced increase of cytosolic calcium in CHO cells by FLIPRActivity at human bradykinin B1 receptor assessed as inhibition of Des-arg kallidin-induced increase of cytosolic calcium in CHO cells by FLIPR
ChEMBL 480 5 2 2 5.0 C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)CC1)c1ccc(-c2cccc(F)c2C(F)(F)F)cc1F 10.1021/jm061094b
CHEMBL221695 91121 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Activity at human bradykinin B1 receptor assessed as inhibition of Des-arg kallidin-induced increase of cytosolic calcium in CHO cells by FLIPRActivity at human bradykinin B1 receptor assessed as inhibition of Des-arg kallidin-induced increase of cytosolic calcium in CHO cells by FLIPR
ChEMBL 480 5 2 2 5.0 C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)CC1)c1ccc(-c2cccc(F)c2C(F)(F)F)cc1F 10.1021/jm061094b
57390411 76849 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 497 5 2 6 2.2 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCC3(OCCO3)c3ccccc32)cc1 10.1016/j.bmcl.2011.11.112
CHEMBL1939772 76849 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 497 5 2 6 2.2 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCC3(OCCO3)c3ccccc32)cc1 10.1016/j.bmcl.2011.11.112
46230458 205998 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilization
ChEMBL 460 6 2 8 4.6 CC(=O)Nc1nonc1NCc1ccc(-c2cc(Cl)cc(F)c2-c2noc(C)n2)cc1F 10.1016/j.bmcl.2009.11.120
CHEMBL589899 205998 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilization
ChEMBL 460 6 2 8 4.6 CC(=O)Nc1nonc1NCc1ccc(-c2cc(Cl)cc(F)c2-c2noc(C)n2)cc1F 10.1016/j.bmcl.2009.11.120
11326315 156820 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 374 4 3 3 4.2 O=C(Nc1[nH]nc(C(=O)Nc2ccccc2)c1Cl)c1ccccc1Cl 10.1021/jm051292n
CHEMBL395055 156820 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 374 4 3 3 4.2 O=C(Nc1[nH]nc(C(=O)Nc2ccccc2)c1Cl)c1ccccc1Cl 10.1021/jm051292n
44410084 83705 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Inhibition of human B1 receptor by calcium influx functional assayInhibition of human B1 receptor by calcium influx functional assay
ChEMBL 591 8 2 4 5.5 O=C(C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCCc2cc(CNCC(F)(F)F)ccc21 10.1016/j.bmcl.2006.01.069
CHEMBL207033 83705 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Inhibition of human B1 receptor by calcium influx functional assayInhibition of human B1 receptor by calcium influx functional assay
ChEMBL 591 8 2 4 5.5 O=C(C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCCc2cc(CNCC(F)(F)F)ccc21 10.1016/j.bmcl.2006.01.069
60143098 132710 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 428 4 2 6 3.5 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)OCC3NC(=O)C2(N)CC2)no1 nan
CHEMBL3648492 132710 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 428 4 2 6 3.5 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)OCC3NC(=O)C2(N)CC2)no1 nan
23630614 148888 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 620 9 2 6 6.0 O=C(Nc1c(Br)c(C(=O)NCCC2CCN(c3ccncc3)CC2)nn1Cc1ccccc1)c1ccccc1Cl 10.1021/jm051292n
CHEMBL388270 148888 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 620 9 2 6 6.0 O=C(Nc1c(Br)c(C(=O)NCCC2CCN(c3ccncc3)CC2)nn1Cc1ccccc1)c1ccccc1Cl 10.1021/jm051292n
44579944 193576 0 None - 1 Crab-eating macaque 6.1 pIC50 = 6.1 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 494 8 1 7 3.8 Cc1nc(-c2ccc(CN(C)C(=O)CNC(=O)c3nc4ccccc4n3Cc3ccccc3)cc2)no1 10.1016/j.bmcl.2008.08.014
CHEMBL489192 193576 0 None - 1 Crab-eating macaque 6.1 pIC50 = 6.1 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 494 8 1 7 3.8 Cc1nc(-c2ccc(CN(C)C(=O)CNC(=O)c3nc4ccccc4n3Cc3ccccc3)cc2)no1 10.1016/j.bmcl.2008.08.014
57400697 76845 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 482 5 2 5 2.0 CC(=O)N1CCC(NC(=O)C[C@@H]2C(=O)NC=CN2S(=O)(=O)c2ccc(C)cc2)c2ccccc21 10.1016/j.bmcl.2011.11.112
CHEMBL1939769 76845 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 482 5 2 5 2.0 CC(=O)N1CCC(NC(=O)C[C@@H]2C(=O)NC=CN2S(=O)(=O)c2ccc(C)cc2)c2ccccc21 10.1016/j.bmcl.2011.11.112
44410316 147641 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Inhibition of human B1 receptor by calcium influx functional assayInhibition of human B1 receptor by calcium influx functional assay
ChEMBL 531 7 2 4 5.4 CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(Cl)c1 10.1016/j.bmcl.2006.01.069
CHEMBL381964 147641 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Inhibition of human B1 receptor by calcium influx functional assayInhibition of human B1 receptor by calcium influx functional assay
ChEMBL 531 7 2 4 5.4 CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(Cl)c1 10.1016/j.bmcl.2006.01.069
11691896 193484 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assay
ChEMBL 504 8 1 4 5.6 O=C(CCCS(=O)(=O)c1ccc2ccccc2c1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2008.07.108
CHEMBL488512 193484 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assay
ChEMBL 504 8 1 4 5.6 O=C(CCCS(=O)(=O)c1ccc2ccccc2c1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2008.07.108
44580046 191027 0 None - 1 Crab-eating macaque 6.1 pIC50 = 6.1 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 438 7 3 5 3.7 O=C(CCNC(=O)c1nc2ccccc2n1Cc1ccccc1)Nc1ccc2nc[nH]c2c1 10.1016/j.bmcl.2008.08.014
CHEMBL483653 191027 0 None - 1 Crab-eating macaque 6.1 pIC50 = 6.1 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 438 7 3 5 3.7 O=C(CCNC(=O)c1nc2ccccc2n1Cc1ccccc1)Nc1ccc2nc[nH]c2c1 10.1016/j.bmcl.2008.08.014
60142025 132669 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 536 7 2 3 5.6 O=C(NC1(C(=O)NC2CCc3cc(-c4cc(Cl)cc(Cl)c4OCC(F)F)ccc32)CC1)C(F)(F)F nan
CHEMBL3648452 132669 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 536 7 2 3 5.6 O=C(NC1(C(=O)NC2CCc3cc(-c4cc(Cl)cc(Cl)c4OCC(F)F)ccc32)CC1)C(F)(F)F nan
57403174 76335 0 None 5 2 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human B1 bradykinin receptor expressed in CHO cells by aqueorin-based calcium flux assayAntagonist activity at human B1 bradykinin receptor expressed in CHO cells by aqueorin-based calcium flux assay
ChEMBL 510 5 1 4 6.4 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3ccc(F)cc3c2=O)c1 10.1016/j.bmcl.2011.10.068
CHEMBL1934256 76335 0 None 5 2 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human B1 bradykinin receptor expressed in CHO cells by aqueorin-based calcium flux assayAntagonist activity at human B1 bradykinin receptor expressed in CHO cells by aqueorin-based calcium flux assay
ChEMBL 510 5 1 4 6.4 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3ccc(F)cc3c2=O)c1 10.1016/j.bmcl.2011.10.068
49863235 22002 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium flux
ChEMBL 613 10 3 4 6.7 C=C(CNC(C)(C)C)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2010.06.010
CHEMBL1210752 22002 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium flux
ChEMBL 613 10 3 4 6.7 C=C(CNC(C)(C)C)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2010.06.010
11421944 92320 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 589 9 3 5 5.6 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1021/jm070055c
CHEMBL227778 92320 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 589 9 3 5 5.6 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1021/jm070055c
11555599 180379 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assay
ChEMBL 534 9 1 5 5.2 CO[C@H](CCS(=O)(=O)c1ccc2ccccc2c1)C(=O)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2008.07.108
CHEMBL453338 180379 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assay
ChEMBL 534 9 1 5 5.2 CO[C@H](CCS(=O)(=O)c1ccc2ccccc2c1)C(=O)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2008.07.108
11526655 193346 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assay
ChEMBL 534 9 1 5 5.2 CO[C@@H](CC(=O)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)CS(=O)(=O)c1ccc2ccccc2c1 10.1016/j.bmcl.2008.07.108
CHEMBL487823 193346 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assay
ChEMBL 534 9 1 5 5.2 CO[C@@H](CC(=O)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)CS(=O)(=O)c1ccc2ccccc2c1 10.1016/j.bmcl.2008.07.108
57398013 76336 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human B1 bradykinin receptor expressed in CHO cells by aqueorin-based calcium flux assayAntagonist activity at human B1 bradykinin receptor expressed in CHO cells by aqueorin-based calcium flux assay
ChEMBL 526 5 1 4 6.9 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3cc(Cl)ccc3c2=O)c1 10.1016/j.bmcl.2011.10.068
CHEMBL1934257 76336 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human B1 bradykinin receptor expressed in CHO cells by aqueorin-based calcium flux assayAntagonist activity at human B1 bradykinin receptor expressed in CHO cells by aqueorin-based calcium flux assay
ChEMBL 526 5 1 4 6.9 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3cc(Cl)ccc3c2=O)c1 10.1016/j.bmcl.2011.10.068
57402467 76841 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 469 6 2 5 2.5 COc1ccc2c(c1)CCCC2NC(=O)C[C@@H]1C(=O)NC=CN1S(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.11.112
CHEMBL1939765 76841 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 469 6 2 5 2.5 COc1ccc2c(c1)CCCC2NC(=O)C[C@@H]1C(=O)NC=CN1S(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.11.112
23627520 80630 0 None - 1 Rat 7.1 pIC50 = 7.1 Functional
Antagonist activity at rat bradykinin B1 receptorAntagonist activity at rat bradykinin B1 receptor
ChEMBL 580 9 2 6 4.7 COc1ccc(S(=O)(=O)N2c3ccccc3-c3ccccc3C2CC(=O)NCCc2ccc(C3=NCCN3)cc2)cc1 10.1016/j.bmcl.2012.03.065
CHEMBL2018870 80630 0 None - 1 Rat 7.1 pIC50 = 7.1 Functional
Antagonist activity at rat bradykinin B1 receptorAntagonist activity at rat bradykinin B1 receptor
ChEMBL 580 9 2 6 4.7 COc1ccc(S(=O)(=O)N2c3ccccc3-c3ccccc3C2CC(=O)NCCc2ccc(C3=NCCN3)cc2)cc1 10.1016/j.bmcl.2012.03.065
44410273 83490 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Inhibition of human B1 receptor by calcium influx functional assayInhibition of human B1 receptor by calcium influx functional assay
ChEMBL 531 7 2 4 5.4 CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1ccc(Cl)cc1 10.1016/j.bmcl.2006.01.069
CHEMBL206541 83490 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Inhibition of human B1 receptor by calcium influx functional assayInhibition of human B1 receptor by calcium influx functional assay
ChEMBL 531 7 2 4 5.4 CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1ccc(Cl)cc1 10.1016/j.bmcl.2006.01.069
11259614 100040 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 455 6 3 4 2.7 CC[C@@H](NC(=O)c1n[nH]c(NC(=O)c2ccccc2Cl)c1Br)C(=O)N(C)C 10.1021/jm051292n
CHEMBL244935 100040 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 455 6 3 4 2.7 CC[C@@H](NC(=O)c1n[nH]c(NC(=O)c2ccccc2Cl)c1Br)C(=O)N(C)C 10.1021/jm051292n
60142168 132676 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 550 7 2 3 6.0 O=C(NC1(C(=O)NC2CCCc3cc(-c4cc(Cl)cc(Cl)c4OCC(F)F)ccc32)CC1)C(F)(F)F nan
CHEMBL3648459 132676 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 550 7 2 3 6.0 O=C(NC1(C(=O)NC2CCCc3cc(-c4cc(Cl)cc(Cl)c4OCC(F)F)ccc32)CC1)C(F)(F)F nan
56951319 76862 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 392 5 3 5 0.2 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)NC2CCNCC2)cc1 10.1016/j.bmcl.2011.11.112
CHEMBL1939927 76862 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 392 5 3 5 0.2 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)NC2CCNCC2)cc1 10.1016/j.bmcl.2011.11.112
57395449 76838 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 413 6 2 4 2.2 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2011.11.112
CHEMBL1939762 76838 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 413 6 2 4 2.2 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2011.11.112
11584184 179892 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assay
ChEMBL 500 8 3 6 2.7 Cc1ccc(S(=O)(=O)C[C@@H](O)[C@@H](O)C(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2008.07.108
CHEMBL452057 179892 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assay
ChEMBL 500 8 3 6 2.7 Cc1ccc(S(=O)(=O)C[C@@H](O)[C@@H](O)C(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2008.07.108
46230310 206984 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilization
ChEMBL 569 8 2 10 5.5 COc1cc(C(=O)Nn2c(NCc3ccc(-c4cc(Cl)cc(F)c4-c4noc(C)n4)cc3F)nc(C)c2C)on1 10.1016/j.bmcl.2009.11.120
CHEMBL596717 206984 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilizationAntagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1-beta assessed as inhibition of DAKD-induced calcium mobilization
ChEMBL 569 8 2 10 5.5 COc1cc(C(=O)Nn2c(NCc3ccc(-c4cc(Cl)cc(F)c4-c4noc(C)n4)cc3F)nc(C)c2C)on1 10.1016/j.bmcl.2009.11.120
11555433 195768 0 None -2 2 Rabbit 7.1 pIC50 = 7.1 Functional
Antagonist activity at rabbit bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assayAntagonist activity at rabbit bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assay
ChEMBL 520 8 3 6 3.0 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1cccc(Cl)c1 10.1016/j.bmcl.2008.07.108
CHEMBL508632 195768 0 None -2 2 Rabbit 7.1 pIC50 = 7.1 Functional
Antagonist activity at rabbit bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assayAntagonist activity at rabbit bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assay
ChEMBL 520 8 3 6 3.0 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1cccc(Cl)c1 10.1016/j.bmcl.2008.07.108
9804704 100039 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 467 6 3 4 3.5 CN1CCC(CCNC(=O)c2n[nH]c(NC(=O)c3ccccc3Cl)c2Br)CC1 10.1021/jm051292n
CHEMBL244934 100039 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 467 6 3 4 3.5 CN1CCC(CCNC(=O)c2n[nH]c(NC(=O)c3ccccc3Cl)c2Br)CC1 10.1021/jm051292n
11467345 168730 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilizationAntagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilization
ChEMBL 581 9 2 4 6.4 O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1021/jm061224g
CHEMBL415629 168730 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilizationAntagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilization
ChEMBL 581 9 2 4 6.4 O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1021/jm061224g
49863228 21992 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium flux
ChEMBL 639 10 2 4 6.8 O=C(C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1)N[C@@H]1CCCc2cc(C3(CN4CCCCC4)CC3)ccc21 10.1016/j.bmcl.2010.06.010
CHEMBL1210742 21992 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium flux
ChEMBL 639 10 2 4 6.8 O=C(C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1)N[C@@H]1CCCc2cc(C3(CN4CCCCC4)CC3)ccc21 10.1016/j.bmcl.2010.06.010
44579915 190978 0 None - 1 Crab-eating macaque 6.1 pIC50 = 6.1 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 514 5 0 6 2.9 CN1CCC(N2CCN(C(=O)[C@@H]3CCCN3C(=O)c3nc4ccccc4n3Cc3ccccc3)CC2)CC1 10.1016/j.bmcl.2008.08.014
CHEMBL483241 190978 0 None - 1 Crab-eating macaque 6.1 pIC50 = 6.1 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 514 5 0 6 2.9 CN1CCC(N2CCN(C(=O)[C@@H]3CCCN3C(=O)c3nc4ccccc4n3Cc3ccccc3)CC2)CC1 10.1016/j.bmcl.2008.08.014
16102920 89985 0 None - 1 Human 8.0 pIC50 = 8.0 Functional
Activity at human bradykinin B1 receptor assessed as inhibition of Des-arg kallidin-induced increase of cytosolic calcium in CHO cells by FLIPRActivity at human bradykinin B1 receptor assessed as inhibition of Des-arg kallidin-induced increase of cytosolic calcium in CHO cells by FLIPR
ChEMBL 500 7 2 4 4.7 CCOC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1021/jm061094b
CHEMBL218553 89985 0 None - 1 Human 8.0 pIC50 = 8.0 Functional
Activity at human bradykinin B1 receptor assessed as inhibition of Des-arg kallidin-induced increase of cytosolic calcium in CHO cells by FLIPRActivity at human bradykinin B1 receptor assessed as inhibition of Des-arg kallidin-induced increase of cytosolic calcium in CHO cells by FLIPR
ChEMBL 500 7 2 4 4.7 CCOC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1021/jm061094b
23630512 99330 0 None - 1 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 466 7 3 5 4.1 Cc1c(C(=O)NCCC2CCN(c3ccncc3)CC2)n[nH]c1NC(=O)c1ccccc1Cl 10.1021/jm051292n
CHEMBL243208 99330 0 None - 1 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assayAntagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
ChEMBL 466 7 3 5 4.1 Cc1c(C(=O)NCCC2CCN(c3ccncc3)CC2)n[nH]c1NC(=O)c1ccccc1Cl 10.1021/jm051292n
16221283 92307 0 None - 1 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 609 12 3 6 4.9 COCCNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(Cl)c(Cl)c1)c1ccc(F)cc1 10.1021/jm070055c
CHEMBL227655 92307 0 None - 1 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 609 12 3 6 4.9 COCCNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(Cl)c(Cl)c1)c1ccc(F)cc1 10.1021/jm070055c
16221109 150825 0 None - 1 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 607 9 3 5 6.1 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(Cl)c(Cl)c1)c1ccc(F)cc1 10.1021/jm070055c
CHEMBL390311 150825 0 None - 1 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 607 9 3 5 6.1 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(Cl)c(Cl)c1)c1ccc(F)cc1 10.1021/jm070055c
11387915 21994 0 None - 1 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium flux
ChEMBL 611 10 2 4 6.4 C=C(CN1CCCC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2010.06.010
CHEMBL1210744 21994 0 None - 1 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium flux
ChEMBL 611 10 2 4 6.4 C=C(CN1CCCC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2010.06.010
16221055 149526 0 None - 1 Human 8.0 pIC50 = 8 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 607 9 3 5 5.8 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1 10.1021/jm070055c
CHEMBL389249 149526 0 None - 1 Human 8.0 pIC50 = 8 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 607 9 3 5 5.8 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1 10.1021/jm070055c
11685446 193483 0 None 14 2 Human 8.0 pIC50 = 8 Functional
Antagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assay
ChEMBL 554 8 3 6 3.7 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1cccc(Cl)c1Cl 10.1016/j.bmcl.2008.07.108
CHEMBL488501 193483 0 None 14 2 Human 8.0 pIC50 = 8 Functional
Antagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assay
ChEMBL 554 8 3 6 3.7 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1cccc(Cl)c1Cl 10.1016/j.bmcl.2008.07.108
57395450 76839 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 425 5 2 4 2.1 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCc3ccccc32)cc1 10.1016/j.bmcl.2011.11.112
CHEMBL1939763 76839 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 425 5 2 4 2.1 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCc3ccccc32)cc1 10.1016/j.bmcl.2011.11.112
44410026 83571 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Inhibition of human B1 receptor by calcium influx functional assayInhibition of human B1 receptor by calcium influx functional assay
ChEMBL 567 7 2 5 5.2 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2006.01.069
CHEMBL206901 83571 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Inhibition of human B1 receptor by calcium influx functional assayInhibition of human B1 receptor by calcium influx functional assay
ChEMBL 567 7 2 5 5.2 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2006.01.069
60142833 132700 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 444 4 2 5 4.2 Cc1nc(-c2c(F)cc(Cl)cc2-c2cc(F)c3c(c2)CCC3NC(=O)C2(N)CC2)no1 nan
CHEMBL3648482 132700 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.Calcium Mobilization Assay: Calcium mobilization assay using Bradykinin-1 receptor.
ChEMBL 444 4 2 5 4.2 Cc1nc(-c2c(F)cc(Cl)cc2-c2cc(F)c3c(c2)CCC3NC(=O)C2(N)CC2)no1 nan
57400937 76847 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 454 5 3 5 1.5 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CC(=O)Nc3ccccc32)cc1 10.1016/j.bmcl.2011.11.112
CHEMBL1939770 76847 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 454 5 3 5 1.5 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CC(=O)Nc3ccccc32)cc1 10.1016/j.bmcl.2011.11.112
16221162 151101 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 611 9 2 5 6.7 CC1CCCC(C)N1Cc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 10.1021/jm070055c
CHEMBL390540 151101 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxAntagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
ChEMBL 611 9 2 5 6.7 CC1CCCC(C)N1Cc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 10.1021/jm070055c
44410368 83536 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Inhibition of human B1 receptor by calcium influx functional assayInhibition of human B1 receptor by calcium influx functional assay
ChEMBL 553 7 2 5 4.8 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1CCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2006.01.069
CHEMBL206801 83536 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Inhibition of human B1 receptor by calcium influx functional assayInhibition of human B1 receptor by calcium influx functional assay
ChEMBL 553 7 2 5 4.8 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1CCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2006.01.069
24946437 193553 0 None - 1 Crab-eating macaque 6.0 pIC50 = 6.0 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 468 7 1 6 2.9 O=C(NCCC(=O)N1CCN(c2ccncc2)CC1)c1nc2ccccc2n1Cc1ccccc1 10.1016/j.bmcl.2008.08.014
CHEMBL488983 193553 0 None - 1 Crab-eating macaque 6.0 pIC50 = 6.0 Functional
Antagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assayAntagonist activity at Cynomolgus monkey bradykinin B1 receptor expressed in CHO cells assessed as calcium transient by FLIPR assay
ChEMBL 468 7 1 6 2.9 O=C(NCCC(=O)N1CCN(c2ccncc2)CC1)c1nc2ccccc2n1Cc1ccccc1 10.1016/j.bmcl.2008.08.014
11605512 180382 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assay
ChEMBL 486 8 3 6 2.4 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1ccccc1 10.1016/j.bmcl.2008.07.108
CHEMBL453340 180382 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assay
ChEMBL 486 8 3 6 2.4 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1ccccc1 10.1016/j.bmcl.2008.07.108
57401425 76338 0 None 1 2 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human B1 bradykinin receptor expressed in CHO cells by aqueorin-based calcium flux assayAntagonist activity at human B1 bradykinin receptor expressed in CHO cells by aqueorin-based calcium flux assay
ChEMBL 492 5 1 4 6.3 O=C(N[C@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3ccccc3c2=O)cc1 10.1016/j.bmcl.2011.10.068
CHEMBL1934259 76338 0 None 1 2 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human B1 bradykinin receptor expressed in CHO cells by aqueorin-based calcium flux assayAntagonist activity at human B1 bradykinin receptor expressed in CHO cells by aqueorin-based calcium flux assay
ChEMBL 492 5 1 4 6.3 O=C(N[C@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3ccccc3c2=O)cc1 10.1016/j.bmcl.2011.10.068
57399670 76332 0 None -13 2 Rabbit 7.0 pIC50 = 7.0 Functional
Antagonist activity at rabbit B1 bradykinin receptor expressed in CHO cellsAntagonist activity at rabbit B1 bradykinin receptor expressed in CHO cells
ChEMBL 506 5 1 5 5.5 Cc1nn(-c2ccc(C(=O)N[C@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2ccccc12 10.1016/j.bmcl.2011.10.068
CHEMBL1934253 76332 0 None -13 2 Rabbit 7.0 pIC50 = 7.0 Functional
Antagonist activity at rabbit B1 bradykinin receptor expressed in CHO cellsAntagonist activity at rabbit B1 bradykinin receptor expressed in CHO cells
ChEMBL 506 5 1 5 5.5 Cc1nn(-c2ccc(C(=O)N[C@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2ccccc12 10.1016/j.bmcl.2011.10.068
54586518 68964 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 552 7 1 5 3.4 Cc1ccc(S(=O)(=O)N2CCN(C)C(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
CHEMBL1777963 68964 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assayAntagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay
ChEMBL 552 7 1 5 3.4 Cc1ccc(S(=O)(=O)N2CCN(C)C(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
642 9088 19 None 2 2 Human 6.0 pIC50 = 6 Functional
Antagonist activity against bradykinin B1 receptor in human HeLa cells assessed as inhibition of Des-Arg9-BK-induced increase in intracellular Ca2+ level by Fluro-4 direct calcium dye based fluorescence assayAntagonist activity against bradykinin B1 receptor in human HeLa cells assessed as inhibition of Des-Arg9-BK-induced increase in intracellular Ca2+ level by Fluro-4 direct calcium dye based fluorescence assay
ChEMBL None None None None 10.1021/acs.jmedchem.6b01011
CHEMBL384721 9088 19 None 2 2 Human 6.0 pIC50 = 6 Functional
Antagonist activity against bradykinin B1 receptor in human HeLa cells assessed as inhibition of Des-Arg9-BK-induced increase in intracellular Ca2+ level by Fluro-4 direct calcium dye based fluorescence assayAntagonist activity against bradykinin B1 receptor in human HeLa cells assessed as inhibition of Des-Arg9-BK-induced increase in intracellular Ca2+ level by Fluro-4 direct calcium dye based fluorescence assay
ChEMBL None None None None 10.1021/acs.jmedchem.6b01011
57394682 76857 0 None - 1 Human 6.0 pIC50 = 6 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 391 5 2 4 1.8 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)NC2CCCCC2)cc1 10.1016/j.bmcl.2011.11.112
CHEMBL1939922 76857 0 None - 1 Human 6.0 pIC50 = 6 Functional
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysisAntagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium level after 1.5 to 2 hrs by luminometry analysis
ChEMBL 391 5 2 4 1.8 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)NC2CCCCC2)cc1 10.1016/j.bmcl.2011.11.112
44354176 103530 0 None - 0 Rat 7.0 pKd = 7 Functional
Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.
ChEMBL 925 28 10 10 0.6 NC(N)=NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)NCCCCCCCCCCCC(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1[C@H](C(=O)O)C[C@@H]2CCCC[C@@H]21 10.1021/jm980495r
CHEMBL264517 103530 0 None - 0 Rat 7.0 pKd = 7 Functional
Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.
ChEMBL 925 28 10 10 0.6 NC(N)=NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)NCCCCCCCCCCCC(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1[C@H](C(=O)O)C[C@@H]2CCCC[C@@H]21 10.1021/jm980495r
44354059 123837 0 None - 0 Rat 7.0 pKd = 7 Functional
Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.
ChEMBL 925 34 11 10 1.8 CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CO)NC(=O)CCCCCCCCCCNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(C)=O)C(=O)O 10.1021/jm980495r
CHEMBL339159 123837 0 None - 0 Rat 7.0 pKd = 7 Functional
Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.
ChEMBL 925 34 11 10 1.8 CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CO)NC(=O)CCCCCCCCCCNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(C)=O)C(=O)O 10.1021/jm980495r
44354039 121994 0 None - 0 Rat 6.0 pKd = 6 Functional
Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.
ChEMBL 883 27 9 10 1.3 NCCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCCCCCCCCCCC(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1[C@H](C(=O)O)C[C@@H]2CCCC[C@@H]21 10.1021/jm980495r
CHEMBL334538 121994 0 None - 0 Rat 6.0 pKd = 6 Functional
Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.
ChEMBL 883 27 9 10 1.3 NCCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCCCCCCCCCCC(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1[C@H](C(=O)O)C[C@@H]2CCCC[C@@H]21 10.1021/jm980495r
44354174 148337 0 None - 0 Rat 5.0 pKd = 5 Functional
Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.
ChEMBL 1081 35 14 12 -1.3 NC(N)=NCCC[C@H](NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2N1C(=O)[C@H](NC(=O)[C@H](CO)NC(=O)CCCCCCCCCCNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CCCN=C(N)N)C1Cc2ccccc2C1)C(=O)O 10.1021/jm980495r
CHEMBL384846 148337 0 None - 0 Rat 5.0 pKd = 5 Functional
Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.
ChEMBL 1081 35 14 12 -1.3 NC(N)=NCCC[C@H](NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2N1C(=O)[C@H](NC(=O)[C@H](CO)NC(=O)CCCCCCCCCCNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CCCN=C(N)N)C1Cc2ccccc2C1)C(=O)O 10.1021/jm980495r
CHEMBL133560 215499 0 None - 0 Rat 5.0 pKd = 5 Functional
Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.
ChEMBL None None None NC(N)=NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)NC1(C(=O)N[C@@H](CO)C(=O)N2Cc3ccccc3C[C@@H]2C(=O)N2[C@H](C(=O)O)C[C@@H]3CCCC[C@@H]32)CCCCC1 10.1021/jm980495r
CHEMBL339389 218400 0 None - 0 Rat 5.9 pKd = 5.9 Functional
Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.
ChEMBL None None None NC(N)=NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)NC1(C(=O)N[C@@H](CO)C(=O)N2Cc3ccccc3C[C@@H]2C(=O)N2[C@H](C(=O)O)C[C@@H]3CCCC[C@@H]32)CCCCCC1 10.1021/jm980495r
56668285 70092 0 None - 0 Rat 6.8 pKd = 6.8 Functional
Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.
ChEMBL 1145 26 13 15 -1.1 C=C([C@H]1Cc2ccccc2CN1C(=O)[C@H](CO)CC(=O)[C@H](Cc1cccs1)NC(=O)CNC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CCCNC(=N)N)N1[C@H](C(=O)O)C[C@@H]2CCCC[C@@H]21 10.1021/jm980495r
CHEMBL1793829 70092 0 None - 0 Rat 6.8 pKd = 6.8 Functional
Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.
ChEMBL 1145 26 13 15 -1.1 C=C([C@H]1Cc2ccccc2CN1C(=O)[C@H](CO)CC(=O)[C@H](Cc1cccs1)NC(=O)CNC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CCCNC(=N)N)N1[C@H](C(=O)O)C[C@@H]2CCCC[C@@H]21 10.1021/jm980495r
CHEMBL2370699 216694 7 None - 0 Rat 7.7 pKd = 7.7 Functional
Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.
ChEMBL None None None NC(N)=NCCC[C@H](NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2N1C(=O)[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CCCN=C(N)N)C1Cc2ccccc2C1)C1Cc2ccccc2C1)C(=O)O 10.1021/jm980495r
44354162 31175 0 None - 0 Rat 5.7 pKd = 5.7 Functional
Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.
ChEMBL 840 22 10 10 -1.7 NC(N)=NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)NCCCCCC(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1[C@H](C(=O)O)C[C@@H]2CCCC[C@@H]21 10.1021/jm980495r
CHEMBL134135 31175 0 None - 0 Rat 5.7 pKd = 5.7 Functional
Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.
ChEMBL 840 22 10 10 -1.7 NC(N)=NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)NCCCCCC(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1[C@H](C(=O)O)C[C@@H]2CCCC[C@@H]21 10.1021/jm980495r
44354032 162526 0 None - 0 Rat 5.7 pKd = 5.7 Functional
Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.
ChEMBL 1037 26 12 12 -1.4 NC(N)=NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)NCCCC(=O)NC1(C(=O)NCCCC(=O)N[C@@H](CO)C(=O)N2Cc3ccccc3C[C@@H]2C(=O)N2[C@H](C(=O)O)C[C@@H]3CCCC[C@@H]32)CCCCCC1 10.1021/jm980495r
CHEMBL405644 162526 0 None - 0 Rat 5.7 pKd = 5.7 Functional
Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.
ChEMBL 1037 26 12 12 -1.4 NC(N)=NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)NCCCC(=O)NC1(C(=O)NCCCC(=O)N[C@@H](CO)C(=O)N2Cc3ccccc3C[C@@H]2C(=O)N2[C@H](C(=O)O)C[C@@H]3CCCC[C@@H]32)CCCCCC1 10.1021/jm980495r
44354038 26627 0 None - 0 Rat 6.6 pKd = 6.6 Functional
Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.
ChEMBL 925 28 9 10 1.5 CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCCCCCCCCCCC(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1[C@H](C(=O)O)C[C@@H]2CCCC[C@@H]21 10.1021/jm980495r
CHEMBL130222 26627 0 None - 0 Rat 6.6 pKd = 6.6 Functional
Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.
ChEMBL 925 28 9 10 1.5 CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCCCCCCCCCCC(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1[C@H](C(=O)O)C[C@@H]2CCCC[C@@H]21 10.1021/jm980495r
44354033 103818 0 None - 0 Rat 5.6 pKd = 5.6 Functional
Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.
ChEMBL 1009 24 12 12 -2.2 NC(N)=NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)NCCC(=O)NC1(C(=O)NCCC(=O)N[C@@H](CO)C(=O)N2Cc3ccccc3C[C@@H]2C(=O)N2[C@H](C(=O)O)C[C@@H]3CCCC[C@@H]32)CCCCCC1 10.1021/jm980495r
CHEMBL266975 103818 0 None - 0 Rat 5.6 pKd = 5.6 Functional
Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.
ChEMBL 1009 24 12 12 -2.2 NC(N)=NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)NCCC(=O)NC1(C(=O)NCCC(=O)N[C@@H](CO)C(=O)N2Cc3ccccc3C[C@@H]2C(=O)N2[C@H](C(=O)O)C[C@@H]3CCCC[C@@H]32)CCCCCC1 10.1021/jm980495r
CHEMBL131647 215471 0 None - 0 Rat 5.5 pKd = 5.5 Functional
Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.
ChEMBL None None None NC(N)=NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)NC1(C(=O)N[C@@H](CO)C(=O)N2Cc3ccccc3C[C@@H]2C(=O)N2[C@H](C(=O)O)C[C@@H]3CCCC[C@@H]32)CCCCCCC1 10.1021/jm980495r
16108961 7710 0 None 2 3 Human 7.4 pKd = 7.4 Functional
Antagonist activity at bradykinin B1 receptor assessed as prevention of Lys-desArg9-Bk-induced contraction in human umbilical veinAntagonist activity at bradykinin B1 receptor assessed as prevention of Lys-desArg9-Bk-induced contraction in human umbilical vein
ChEMBL 583 9 2 5 5.9 O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 10.1021/jm061224g
664 7710 0 None 2 3 Human 7.4 pKd = 7.4 Functional
Antagonist activity at bradykinin B1 receptor assessed as prevention of Lys-desArg9-Bk-induced contraction in human umbilical veinAntagonist activity at bradykinin B1 receptor assessed as prevention of Lys-desArg9-Bk-induced contraction in human umbilical vein
ChEMBL 583 9 2 5 5.9 O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 10.1021/jm061224g
CHEMBL415848 7710 0 None 2 3 Human 7.4 pKd = 7.4 Functional
Antagonist activity at bradykinin B1 receptor assessed as prevention of Lys-desArg9-Bk-induced contraction in human umbilical veinAntagonist activity at bradykinin B1 receptor assessed as prevention of Lys-desArg9-Bk-induced contraction in human umbilical vein
ChEMBL 583 9 2 5 5.9 O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 10.1021/jm061224g
44354214 122286 0 None - 0 Rat 5.4 pKd = 5.4 Functional
Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.
ChEMBL 869 24 10 10 -1.0 NC(N)=NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)NCCCCCCCC(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1[C@H](C(=O)O)C[C@@H]2CCCC[C@@H]21 10.1021/jm980495r
CHEMBL335247 122286 0 None - 0 Rat 5.4 pKd = 5.4 Functional
Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.
ChEMBL 869 24 10 10 -1.0 NC(N)=NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)NCCCCCCCC(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1[C@H](C(=O)O)C[C@@H]2CCCC[C@@H]21 10.1021/jm980495r
44354175 103683 0 None - 0 Rat 6.3 pKd = 6.3 Functional
Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.
ChEMBL 1025 35 12 12 0.8 NCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCCCCCCCCCCC(=O)N[C@@H](CO)C(=O)N[C@@H](C(=O)N1[C@H]2CCCC[C@H]2C[C@@H]1C(=O)O)C1Cc2ccccc2C1 10.1021/jm980495r
CHEMBL265814 103683 0 None - 0 Rat 6.3 pKd = 6.3 Functional
Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.
ChEMBL 1025 35 12 12 0.8 NCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCCCCCCCCCCC(=O)N[C@@H](CO)C(=O)N[C@@H](C(=O)N1[C@H]2CCCC[C@H]2C[C@@H]1C(=O)O)C1Cc2ccccc2C1 10.1021/jm980495r
44354187 123578 0 None - 0 Rat 6.3 pKd = 6.3 Functional
Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.
ChEMBL 925 29 11 10 0.2 NC(N)=NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)NCCCCCCCCCCC(=O)N[C@@H](CO)C(=O)N[C@@H](C(=O)N1[C@@H](C(=O)O)C[C@H]2CCCC[C@H]21)C1Cc2ccccc2C1 10.1021/jm980495r
CHEMBL337833 123578 0 None - 0 Rat 6.3 pKd = 6.3 Functional
Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.
ChEMBL 925 29 11 10 0.2 NC(N)=NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)NCCCCCCCCCCC(=O)N[C@@H](CO)C(=O)N[C@@H](C(=O)N1[C@@H](C(=O)O)C[C@H]2CCCC[C@H]21)C1Cc2ccccc2C1 10.1021/jm980495r
CHEMBL410363 219595 24 None - 0 Rat 7.2 pKd = 7.2 Functional
Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(C)=O)C(=O)O 10.1021/jm980495r
CHEMBL133164 215492 0 None - 0 Rat 5.2 pKd = 5.2 Functional
Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.
ChEMBL None None None NC(N)=NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)NC1(C(=O)N[C@@H](CO)C(=O)N2Cc3ccccc3C[C@@H]2C(=O)N2[C@H](C(=O)O)C[C@@H]3CCCC[C@@H]32)CCCCCCCC1 10.1021/jm980495r
CHEMBL218454 216176 0 None - 0 Rat 5.2 pKd = 5.2 Functional
Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.
ChEMBL None None None NC(N)=NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)NCC(=O)NC1(C(=O)NCC(=O)N[C@@H](CO)C(=O)N2Cc3ccccc3C[C@@H]2C(=O)N2[C@H](C(=O)O)C[C@@H]3CCCC[C@@H]32)CCCCCC1 10.1021/jm980495r
CHEMBL2370700 216695 0 None - 0 Rat 8.1 pKd = 8.1 Functional
Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.
ChEMBL None None None NCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](C(=O)N1[C@H](C(=O)O)C[C@@H]2CCCC[C@@H]21)C1Cc2ccccc2C1)C1Cc2ccccc2C1 10.1021/jm980495r
44354179 172373 0 None - 0 Rat 7.1 pKd = 7.1 Functional
Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.
ChEMBL 911 27 10 10 0.2 NC(N)=NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)NCCCCCCCCCCC(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1[C@H](C(=O)O)C[C@@H]2CCCC[C@@H]21 10.1021/jm980495r
CHEMBL424272 172373 0 None - 0 Rat 7.1 pKd = 7.1 Functional
Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.
ChEMBL 911 27 10 10 0.2 NC(N)=NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)NCCCCCCCCCCC(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1[C@H](C(=O)O)C[C@@H]2CCCC[C@@H]21 10.1021/jm980495r
44354239 148379 0 None - 0 Rat 6.1 pKd = 6.1 Functional
Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.
ChEMBL 1011 33 11 12 0.9 NCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCCCCCCCCCCC(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1[C@H](C(=O)O)C[C@@H]2CCCC[C@@H]21 10.1021/jm980495r
CHEMBL385081 148379 0 None - 0 Rat 6.1 pKd = 6.1 Functional
Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.Antagonistic activity against Bradykinin receptor B1 of rat ileum longitudinal smooth muscle.
ChEMBL 1011 33 11 12 0.9 NCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCCCCCCCCCCC(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1[C@H](C(=O)O)C[C@@H]2CCCC[C@@H]21 10.1021/jm980495r
11620871 172814 0 None - 0 Human 10.4 pKi = 10.4 Functional
Antagonist activity at human bradykinin B1 receptor expressed in human HEK293 cells assessed as calcium flux by FLIPR assayAntagonist activity at human bradykinin B1 receptor expressed in human HEK293 cells assessed as calcium flux by FLIPR assay
ChEMBL 543 7 1 7 4.8 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(c4ccncc4)CC3)cn2)c(F)c1 10.1021/jm200371q
CHEMBL425588 172814 0 None - 0 Human 10.4 pKi = 10.4 Functional
Antagonist activity at human bradykinin B1 receptor expressed in human HEK293 cells assessed as calcium flux by FLIPR assayAntagonist activity at human bradykinin B1 receptor expressed in human HEK293 cells assessed as calcium flux by FLIPR assay
ChEMBL 543 7 1 7 4.8 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(c4ccncc4)CC3)cn2)c(F)c1 10.1021/jm200371q
53248885 68959 0 None 18 2 Human 10.0 pKi = 10 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 538 7 2 5 3.1 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1021/jm200808v
CHEMBL1777958 68959 0 None 18 2 Human 10.0 pKi = 10 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 538 7 2 5 3.1 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1021/jm200808v
11342704 68957 0 None - 1 Human 10.0 pKi = 10 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 642 7 2 6 4.2 O=C(CC1C(=O)NCCN1S(=O)(=O)c1sc(Cl)cc1Br)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2011.03.115
CHEMBL1777956 68957 0 None - 1 Human 10.0 pKi = 10 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 642 7 2 6 4.2 O=C(CC1C(=O)NCCN1S(=O)(=O)c1sc(Cl)cc1Br)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2011.03.115
11215677 68958 0 None - 1 Human 10.0 pKi = 10 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 614 7 2 6 4.6 O=C(CC1C(=O)NCCN1S(=O)(=O)c1cc2cc(Cl)ccc2s1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2011.03.115
CHEMBL1777957 68958 0 None - 1 Human 10.0 pKi = 10 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 614 7 2 6 4.6 O=C(CC1C(=O)NCCN1S(=O)(=O)c1cc2cc(Cl)ccc2s1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2011.03.115
44587187 195490 0 None - 1 Human 10.0 pKi = 10 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 640 7 2 5 6.1 O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2011.03.115
CHEMBL504531 195490 0 None - 1 Human 10.0 pKi = 10 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 640 7 2 5 6.1 O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2011.03.115
54582655 68970 0 None - 1 Human 10.0 pKi = 10.0 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 552 7 2 5 3.3 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCC(C)CC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
CHEMBL1777969 68970 0 None - 1 Human 10.0 pKi = 10.0 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 552 7 2 5 3.3 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCC(C)CC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
25195622 68956 0 None - 1 Human 9.9 pKi = 9.9 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 606 7 2 5 4.1 Cc1ccc(S(=O)(=O)N2CCNC(=O)C2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1C(F)(F)F 10.1016/j.bmcl.2011.03.115
CHEMBL1777955 68956 0 None - 1 Human 9.9 pKi = 9.9 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 606 7 2 5 4.1 Cc1ccc(S(=O)(=O)N2CCNC(=O)C2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1C(F)(F)F 10.1016/j.bmcl.2011.03.115
11215488 68955 0 None - 1 Human 9.8 pKi = 9.8 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 592 7 2 5 3.8 O=C(CC1C(=O)NCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2011.03.115
CHEMBL1777954 68955 0 None - 1 Human 9.8 pKi = 9.8 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 592 7 2 5 3.8 O=C(CC1C(=O)NCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2011.03.115
53248885 68959 0 None 18 2 Human 9.8 pKi = 9.8 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 538 7 2 5 3.1 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
CHEMBL1777958 68959 0 None 18 2 Human 9.8 pKi = 9.8 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 538 7 2 5 3.1 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
54580628 68945 0 None - 1 Human 9.8 pKi = 9.8 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 592 7 2 5 4.1 O=C(CC1C(=O)NCCN1S(=O)(=O)c1ccc(Cl)c(Cl)c1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2011.03.115
CHEMBL1777879 68945 0 None - 1 Human 9.8 pKi = 9.8 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 592 7 2 5 4.1 O=C(CC1C(=O)NCCN1S(=O)(=O)c1ccc(Cl)c(Cl)c1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2011.03.115
54583617 68969 0 None - 1 Human 9.7 pKi = 9.7 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 540 7 2 6 2.5 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCOc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
CHEMBL1777968 68969 0 None - 1 Human 9.7 pKi = 9.7 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 540 7 2 6 2.5 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCOc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
54581634 68950 0 None - 1 Human 9.7 pKi = 9.7 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 592 7 2 5 4.1 O=C(CC1C(=O)NCCN1S(=O)(=O)c1ccc(Cl)cc1Cl)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2011.03.115
CHEMBL1777884 68950 0 None - 1 Human 9.7 pKi = 9.7 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 592 7 2 5 4.1 O=C(CC1C(=O)NCCN1S(=O)(=O)c1ccc(Cl)cc1Cl)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2011.03.115
54586519 68978 0 None - 1 Human 9.7 pKi = 9.7 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 524 9 3 5 2.6 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNCC4CC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
CHEMBL1777977 68978 0 None - 1 Human 9.7 pKi = 9.7 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 524 9 3 5 2.6 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNCC4CC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
11341479 68979 0 None - 1 Human 9.5 pKi = 9.5 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 526 9 3 5 2.8 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNCC(C)C)ccc32)cc1 10.1016/j.bmcl.2011.03.115
CHEMBL1777978 68979 0 None - 1 Human 9.5 pKi = 9.5 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 526 9 3 5 2.8 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNCC(C)C)ccc32)cc1 10.1016/j.bmcl.2011.03.115
56594769 72500 0 None 6 2 Human 9.5 pKi = 9.5 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 541 5 1 6 5.5 Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cn2)c(=O)c2c(Cl)cccc12 10.1021/jm200808v
CHEMBL1834619 72500 0 None 6 2 Human 9.5 pKi = 9.5 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 541 5 1 6 5.5 Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cn2)c(=O)c2c(Cl)cccc12 10.1021/jm200808v
11214819 68951 0 None - 1 Human 9.5 pKi = 9.5 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 538 7 2 5 3.1 Cc1ccc(S(=O)(=O)N2CCNC(=O)C2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
CHEMBL1777885 68951 0 None - 1 Human 9.5 pKi = 9.5 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 538 7 2 5 3.1 Cc1ccc(S(=O)(=O)N2CCNC(=O)C2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
11387387 68968 0 None - 1 Human 9.5 pKi = 9.5 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 558 7 2 5 3.4 O=C(C[C@@H]1C(=O)NCCN1S(=O)(=O)c1ccc(Cl)cc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2011.03.115
CHEMBL1777967 68968 0 None - 1 Human 9.5 pKi = 9.5 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 558 7 2 5 3.4 O=C(C[C@@H]1C(=O)NCCN1S(=O)(=O)c1ccc(Cl)cc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2011.03.115
16221282 92312 0 None 13 2 Human 9.4 pKi = 9.4 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 619 9 2 5 5.9 O=C(C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1)N[C@@H]1CCOc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2011.03.115
CHEMBL227713 92312 0 None 13 2 Human 9.4 pKi = 9.4 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 619 9 2 5 5.9 O=C(C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1)N[C@@H]1CCOc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2011.03.115
11168954 68948 0 None - 1 Human 9.4 pKi = 9.4 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 558 7 2 5 3.4 O=C(CC1C(=O)NCCN1S(=O)(=O)c1ccccc1Cl)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2011.03.115
CHEMBL1777882 68948 0 None - 1 Human 9.4 pKi = 9.4 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 558 7 2 5 3.4 O=C(CC1C(=O)NCCN1S(=O)(=O)c1ccccc1Cl)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2011.03.115
11342350 68953 0 None - 1 Human 9.3 pKi = 9.3 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 592 7 2 5 3.8 O=C(CC1C(=O)NCCN1S(=O)(=O)c1ccc(C(F)(F)F)cc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2011.03.115
CHEMBL1777887 68953 0 None - 1 Human 9.3 pKi = 9.3 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 592 7 2 5 3.8 O=C(CC1C(=O)NCCN1S(=O)(=O)c1ccc(C(F)(F)F)cc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2011.03.115
54587552 68967 0 None - 1 Human 9.3 pKi = 9.3 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 524 7 2 5 2.7 O=C(C[C@@H]1C(=O)NCCN1S(=O)(=O)c1ccccc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2011.03.115
CHEMBL1777966 68967 0 None - 1 Human 9.3 pKi = 9.3 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 524 7 2 5 2.7 O=C(C[C@@H]1C(=O)NCCN1S(=O)(=O)c1ccccc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2011.03.115
54581667 68976 0 None - 1 Human 9.3 pKi = 9.3 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 538 8 3 5 3.1 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC4CCCC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
CHEMBL1777975 68976 0 None - 1 Human 9.3 pKi = 9.3 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 538 8 3 5 3.1 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC4CCCC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
54581635 68952 0 None - 1 Human 9.3 pKi = 9.3 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 554 8 2 6 2.8 COc1ccc(S(=O)(=O)N2CCNC(=O)C2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
CHEMBL1777886 68952 0 None - 1 Human 9.3 pKi = 9.3 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 554 8 2 6 2.8 COc1ccc(S(=O)(=O)N2CCNC(=O)C2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
56589598 72556 0 None 7 2 Human 9.2 pKi = 9.2 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 543 5 1 6 5.2 Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cn2)c(=O)c2c(F)ccc(F)c12 10.1021/jm200808v
CHEMBL1834751 72556 0 None 7 2 Human 9.2 pKi = 9.2 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 543 5 1 6 5.2 Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cn2)c(=O)c2c(F)ccc(F)c12 10.1021/jm200808v
54772237 72557 0 None 6 2 Human 9.2 pKi = 9.2 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 525 5 1 6 5.0 Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cn2)c(=O)c2c(F)cccc12 10.1021/jm200808v
CHEMBL1834752 72557 0 None 6 2 Human 9.2 pKi = 9.2 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 525 5 1 6 5.0 Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cn2)c(=O)c2c(F)cccc12 10.1021/jm200808v
54587514 68949 0 None - 1 Human 9.2 pKi = 9.2 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 558 7 2 5 3.4 O=C(CC1C(=O)NCCN1S(=O)(=O)c1ccc(Cl)cc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2011.03.115
CHEMBL1777883 68949 0 None - 1 Human 9.2 pKi = 9.2 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 558 7 2 5 3.4 O=C(CC1C(=O)NCCN1S(=O)(=O)c1ccc(Cl)cc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2011.03.115
56594642 72497 0 None 21 2 Human 9.1 pKi = 9.1 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 540 5 1 5 6.1 Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2c(Cl)cccc12 10.1021/jm200808v
CHEMBL1834616 72497 0 None 21 2 Human 9.1 pKi = 9.1 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 540 5 1 5 6.1 Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2c(Cl)cccc12 10.1021/jm200808v
9894973 108535 0 None - 0 Rat 9.0 pKi = 9.0 Functional
Antagonist activity at rat bradykinin B1 receptorAntagonist activity at rat bradykinin B1 receptor
ChEMBL 601 9 2 6 5.7 CCCN1C(=O)C(NC(=O)Nc2ccc(N3CCN(c4ccncc4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 10.1016/j.bmcl.2008.08.014
CHEMBL299832 108535 0 None - 0 Rat 9.0 pKi = 9.0 Functional
Antagonist activity at rat bradykinin B1 receptorAntagonist activity at rat bradykinin B1 receptor
ChEMBL 601 9 2 6 5.7 CCCN1C(=O)C(NC(=O)Nc2ccc(N3CCN(c4ccncc4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 10.1016/j.bmcl.2008.08.014
54582656 68975 0 None - 1 Human 9.0 pKi = 9.0 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 510 8 3 5 2.3 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC4CC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
CHEMBL1777974 68975 0 None - 1 Human 9.0 pKi = 9.0 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 510 8 3 5 2.3 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC4CC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
11364466 68947 0 None - 1 Human 8.9 pKi = 8.9 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 524 7 2 5 2.7 O=C(CC1C(=O)NCCN1S(=O)(=O)c1ccccc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2011.03.115
CHEMBL1777881 68947 0 None - 1 Human 8.9 pKi = 8.9 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 524 7 2 5 2.7 O=C(CC1C(=O)NCCN1S(=O)(=O)c1ccccc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2011.03.115
54587553 68980 0 None - 1 Human 8.8 pKi = 8.8 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 540 8 3 5 3.2 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNCC(C)(C)C)ccc32)cc1 10.1016/j.bmcl.2011.03.115
CHEMBL1777979 68980 0 None - 1 Human 8.8 pKi = 8.8 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 540 8 3 5 3.2 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNCC(C)(C)C)ccc32)cc1 10.1016/j.bmcl.2011.03.115
56594640 72495 0 None - 0 Human 8.7 pKi = 8.7 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 524 5 1 5 5.6 Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2c(F)cccc12 10.1021/jm200808v
CHEMBL1834614 72495 0 None - 0 Human 8.7 pKi = 8.7 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 524 5 1 5 5.6 Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2c(F)cccc12 10.1021/jm200808v
54581666 68971 0 None - 1 Human 8.7 pKi = 8.7 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 566 7 2 5 3.7 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCC(C)(C)C4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
CHEMBL1777970 68971 0 None - 1 Human 8.7 pKi = 8.7 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 566 7 2 5 3.7 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCC(C)(C)C4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
10388673 78178 0 None - 0 Human 7.9 pKi = 7.9 Functional
Antagonist activity at Bradykinin B1 receptorAntagonist activity at Bradykinin B1 receptor
ChEMBL 443 7 2 5 5.0 COC(=O)c1ccccc1-c1ccc(CNc2ncccc2NC(=O)CC(F)(F)F)cc1 10.1021/jm1013693
CHEMBL195883 78178 0 None - 0 Human 7.9 pKi = 7.9 Functional
Antagonist activity at Bradykinin B1 receptorAntagonist activity at Bradykinin B1 receptor
ChEMBL 443 7 2 5 5.0 COC(=O)c1ccccc1-c1ccc(CNc2ncccc2NC(=O)CC(F)(F)F)cc1 10.1021/jm1013693
16221282 92312 0 None - 2 Rat 6.9 pKi = 6.9 Functional
Antagonist activity at rat bradykinin B1 receptorAntagonist activity at rat bradykinin B1 receptor
ChEMBL 619 9 2 5 5.9 O=C(C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1)N[C@@H]1CCOc2cc(CN3CCCCC3)ccc21 10.1021/jm070055c
CHEMBL227713 92312 0 None - 2 Rat 6.9 pKi = 6.9 Functional
Antagonist activity at rat bradykinin B1 receptorAntagonist activity at rat bradykinin B1 receptor
ChEMBL 619 9 2 5 5.9 O=C(C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1)N[C@@H]1CCOc2cc(CN3CCCCC3)ccc21 10.1021/jm070055c
16221108 92306 0 None - 2 Rat 6.8 pKi = 6.8 Functional
Antagonist activity at rat bradykinin B1 receptorAntagonist activity at rat bradykinin B1 receptor
ChEMBL 605 9 2 5 5.5 O=C(C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1)N[C@@H]1CCOc2cc(CN3CCCC3)ccc21 10.1021/jm070055c
CHEMBL227600 92306 0 None - 2 Rat 6.8 pKi = 6.8 Functional
Antagonist activity at rat bradykinin B1 receptorAntagonist activity at rat bradykinin B1 receptor
ChEMBL 605 9 2 5 5.5 O=C(C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1)N[C@@H]1CCOc2cc(CN3CCCC3)ccc21 10.1021/jm070055c
56594371 72655 0 None - 0 Human 6.8 pKi = 6.8 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 508 5 1 4 6.7 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2csc3ccccc3c2=O)c1 10.1021/jm200808v
CHEMBL1835760 72655 0 None - 0 Human 6.8 pKi = 6.8 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 508 5 1 4 6.7 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2csc3ccccc3c2=O)c1 10.1021/jm200808v
16102897 94014 17 None - 1 Rat 5.8 pKi = 5.8 Functional
Antagonist activity at rat bradykinin B1 receptorAntagonist activity at rat bradykinin B1 receptor
ChEMBL 486 6 2 4 4.3 COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1016/j.bmcl.2008.08.014
CHEMBL232943 94014 17 None - 1 Rat 5.8 pKi = 5.8 Functional
Antagonist activity at rat bradykinin B1 receptorAntagonist activity at rat bradykinin B1 receptor
ChEMBL 486 6 2 4 4.3 COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1016/j.bmcl.2008.08.014
56672397 72647 0 None - 1 Human 5.8 pKi = 5.8 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 432 9 1 3 5.6 O=C(CCCCC(=O)c1ccccc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1021/jm200808v
CHEMBL1835752 72647 0 None - 1 Human 5.8 pKi = 5.8 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 432 9 1 3 5.6 O=C(CCCCC(=O)c1ccccc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1021/jm200808v
54580655 68963 0 None - 1 Human 7.8 pKi = 7.8 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 566 7 2 5 3.8 Cc1ccc(S(=O)(=O)N2CC(C)(C)NC(=O)C2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
CHEMBL1777962 68963 0 None - 1 Human 7.8 pKi = 7.8 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 566 7 2 5 3.8 Cc1ccc(S(=O)(=O)N2CC(C)(C)NC(=O)C2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
56594372 72656 0 None - 0 Human 7.8 pKi = 7.8 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 508 5 1 4 6.7 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2csc3ccccc3c2=O)cc1 10.1021/jm200808v
CHEMBL1835761 72656 0 None - 0 Human 7.8 pKi = 7.8 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 508 5 1 4 6.7 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2csc3ccccc3c2=O)cc1 10.1021/jm200808v
56594242 72652 0 None - 0 Human 6.7 pKi = 6.7 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 492 5 1 4 6.3 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3ccccc3c2=O)cc1 10.1021/jm200808v
CHEMBL1835757 72652 0 None - 0 Human 6.7 pKi = 6.7 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 492 5 1 4 6.3 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3ccccc3c2=O)cc1 10.1021/jm200808v
44569935 176271 0 None - 0 Human 6.7 pKi = 6.7 Functional
Antagonist activity at human cloned B1 receptor expressed in african green monkey COS7 cells by calcium mobilization assayAntagonist activity at human cloned B1 receptor expressed in african green monkey COS7 cells by calcium mobilization assay
ChEMBL 646 13 1 6 5.3 CC(C)COc1ccc(CN(CC(=O)NCc2ccccc2Cl)S(=O)(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Cl 10.1016/j.bmcl.2008.11.005
CHEMBL443207 176271 0 None - 0 Human 6.7 pKi = 6.7 Functional
Antagonist activity at human cloned B1 receptor expressed in african green monkey COS7 cells by calcium mobilization assayAntagonist activity at human cloned B1 receptor expressed in african green monkey COS7 cells by calcium mobilization assay
ChEMBL 646 13 1 6 5.3 CC(C)COc1ccc(CN(CC(=O)NCc2ccccc2Cl)S(=O)(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Cl 10.1016/j.bmcl.2008.11.005
56594643 72498 0 None - 0 Human 6.7 pKi = 6.7 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 540 5 1 5 6.1 Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2cc(Cl)ccc12 10.1021/jm200808v
CHEMBL1834617 72498 0 None - 0 Human 6.7 pKi = 6.7 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 540 5 1 5 6.1 Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2cc(Cl)ccc12 10.1021/jm200808v
11284304 68973 0 None - 1 Human 8.6 pKi = 8.6 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 553 7 2 6 1.8 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCN(C)CC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
CHEMBL1777972 68973 0 None - 1 Human 8.6 pKi = 8.6 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 553 7 2 6 1.8 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCN(C)CC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
56594772 72555 0 None 15 2 Human 8.6 pKi = 8.6 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 542 5 1 6 5.6 Cc1nn(-c2ccc(C(=O)N[C@@H]3CCOc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2c(Cl)cccc12 10.1021/jm200808v
CHEMBL1834750 72555 0 None 15 2 Human 8.6 pKi = 8.6 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 542 5 1 6 5.6 Cc1nn(-c2ccc(C(=O)N[C@@H]3CCOc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2c(Cl)cccc12 10.1021/jm200808v
16221056 92334 0 None - 2 Rat 6.7 pKi = 6.7 Functional
Antagonist activity at rat bradykinin B1 receptorAntagonist activity at rat bradykinin B1 receptor
ChEMBL 609 12 3 6 4.6 COCCNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1 10.1021/jm070055c
CHEMBL227870 92334 0 None - 2 Rat 6.7 pKi = 6.7 Functional
Antagonist activity at rat bradykinin B1 receptorAntagonist activity at rat bradykinin B1 receptor
ChEMBL 609 12 3 6 4.6 COCCNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1 10.1021/jm070055c
56594507 72662 0 None - 0 Human 6.7 pKi = 6.7 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 534 6 1 5 6.3 CC(C)c1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2ccccc12 10.1021/jm200808v
CHEMBL1835768 72662 0 None - 0 Human 6.7 pKi = 6.7 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 534 6 1 5 6.3 CC(C)c1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2ccccc12 10.1021/jm200808v
11284458 147366 2 None - 1 Human 7.6 pKi = 7.6 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 565 7 2 4 5.7 CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2011.03.115
CHEMBL381366 147366 2 None - 1 Human 7.6 pKi = 7.6 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 565 7 2 4 5.7 CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2011.03.115
44569936 179964 0 None - 0 Human 6.6 pKi = 6.6 Functional
Antagonist activity at human cloned B1 receptor expressed in african green monkey COS7 cells by calcium mobilization assayAntagonist activity at human cloned B1 receptor expressed in african green monkey COS7 cells by calcium mobilization assay
ChEMBL 627 14 1 6 5.9 COc1cc(CN(CC(=O)NCc2ccccc2Cl)S(=O)(=O)c2ccc(CN3CCCCC3)cc2)ccc1OCC(C)C 10.1016/j.bmcl.2008.11.005
CHEMBL452238 179964 0 None - 0 Human 6.6 pKi = 6.6 Functional
Antagonist activity at human cloned B1 receptor expressed in african green monkey COS7 cells by calcium mobilization assayAntagonist activity at human cloned B1 receptor expressed in african green monkey COS7 cells by calcium mobilization assay
ChEMBL 627 14 1 6 5.9 COc1cc(CN(CC(=O)NCc2ccccc2Cl)S(=O)(=O)c2ccc(CN3CCCCC3)cc2)ccc1OCC(C)C 10.1016/j.bmcl.2008.11.005
56594506 72661 0 None - 0 Human 7.5 pKi = 7.5 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 520 6 1 5 5.7 CCc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2ccccc12 10.1021/jm200808v
CHEMBL1835767 72661 0 None - 0 Human 7.5 pKi = 7.5 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 520 6 1 5 5.7 CCc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2ccccc12 10.1021/jm200808v
56658544 72648 0 None - 0 Human 6.5 pKi = 6.5 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 466 7 1 3 5.9 O=C(Cc1ccc(C(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1)c1ccccc1 10.1021/jm200808v
CHEMBL1835753 72648 0 None - 0 Human 6.5 pKi = 6.5 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 466 7 1 3 5.9 O=C(Cc1ccc(C(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1)c1ccccc1 10.1021/jm200808v
11272685 68972 0 None - 1 Human 8.5 pKi = 8.5 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 540 7 2 6 1.9 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCOCC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
CHEMBL1777971 68972 0 None - 1 Human 8.5 pKi = 8.5 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 540 7 2 6 1.9 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCOCC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
56594770 72502 0 None 7 2 Human 8.5 pKi = 8.5 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 541 5 1 6 5.5 Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)nc2)c(=O)c2c(Cl)cccc12 10.1021/jm200808v
CHEMBL1834620 72502 0 None 7 2 Human 8.5 pKi = 8.5 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 541 5 1 6 5.5 Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)nc2)c(=O)c2c(Cl)cccc12 10.1021/jm200808v
56594641 72496 0 None - 0 Human 8.5 pKi = 8.5 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 542 5 1 5 5.8 Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2c(F)ccc(F)c12 10.1021/jm200808v
CHEMBL1834615 72496 0 None - 0 Human 8.5 pKi = 8.5 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 542 5 1 5 5.8 Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2c(F)ccc(F)c12 10.1021/jm200808v
54587550 68960 0 None - 1 Human 7.5 pKi = 7.5 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 538 7 2 5 3.1 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
CHEMBL1777959 68960 0 None - 1 Human 7.5 pKi = 7.5 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 538 7 2 5 3.1 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
56679097 72650 0 None - 0 Human 6.5 pKi = 6.5 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 466 7 1 3 5.9 O=C(Cc1cccc(C(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)c1)c1ccccc1 10.1021/jm200808v
CHEMBL1835755 72650 0 None - 0 Human 6.5 pKi = 6.5 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 466 7 1 3 5.9 O=C(Cc1cccc(C(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)c1)c1ccccc1 10.1021/jm200808v
56594243 72653 0 None - 0 Human 6.5 pKi = 6.5 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 505 5 1 4 6.0 Cn1cc(-c2cccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)c2)c(=O)c2ccccc21 10.1021/jm200808v
CHEMBL1835758 72653 0 None - 0 Human 6.5 pKi = 6.5 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 505 5 1 4 6.0 Cn1cc(-c2cccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)c2)c(=O)c2ccccc21 10.1021/jm200808v
56594374 72658 0 None - 0 Human 7.5 pKi = 7.5 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 506 5 1 5 5.5 Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2ccccc12 10.1021/jm200808v
CHEMBL1835763 72658 0 None - 0 Human 7.5 pKi = 7.5 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 506 5 1 5 5.5 Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2ccccc12 10.1021/jm200808v
11495796 80310 0 None - 0 Human 5.5 pKi = 5.5 Functional
Antagonist activity at Bradykinin B1 receptorAntagonist activity at Bradykinin B1 receptor
ChEMBL 436 7 2 4 3.6 COC(=O)c1ccccc1-c1ccc(CNC(=O)C(C)(C)NC(=O)CC(F)(F)F)cc1 10.1021/jm1013693
CHEMBL201717 80310 0 None - 0 Human 5.5 pKi = 5.5 Functional
Antagonist activity at Bradykinin B1 receptorAntagonist activity at Bradykinin B1 receptor
ChEMBL 436 7 2 4 3.6 COC(=O)c1ccccc1-c1ccc(CNC(=O)C(C)(C)NC(=O)CC(F)(F)F)cc1 10.1021/jm1013693
25181410 178993 1 None - 0 Human 7.4 pKi = 7.4 Functional
Antagonist activity at human cloned B1 receptor expressed in african green monkey COS7 cells by calcium mobilization assayAntagonist activity at human cloned B1 receptor expressed in african green monkey COS7 cells by calcium mobilization assay
ChEMBL 642 14 1 7 4.6 COc1cc(CN(CC(=O)NCc2ccccc2Cl)S(=O)(=O)c2ccc(CN3CCN(C)CC3)cc2)ccc1OCC(C)C 10.1016/j.bmcl.2008.11.005
CHEMBL447392 178993 1 None - 0 Human 7.4 pKi = 7.4 Functional
Antagonist activity at human cloned B1 receptor expressed in african green monkey COS7 cells by calcium mobilization assayAntagonist activity at human cloned B1 receptor expressed in african green monkey COS7 cells by calcium mobilization assay
ChEMBL 642 14 1 7 4.6 COc1cc(CN(CC(=O)NCc2ccccc2Cl)S(=O)(=O)c2ccc(CN3CCN(C)CC3)cc2)ccc1OCC(C)C 10.1016/j.bmcl.2008.11.005
11635365 181340 0 None 2 2 Human 8.4 pKi = 8.4 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 554 8 3 6 3.4 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1cccc(C(F)(F)F)c1 10.1021/jm200808v
CHEMBL455642 181340 0 None 2 2 Human 8.4 pKi = 8.4 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 554 8 3 6 3.4 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1cccc(C(F)(F)F)c1 10.1021/jm200808v
54585540 68977 0 None - 1 Human 8.4 pKi = 8.4 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 526 7 3 5 3.0 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC(C)(C)C)ccc32)cc1 10.1016/j.bmcl.2011.03.115
CHEMBL1777976 68977 0 None - 1 Human 8.4 pKi = 8.4 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 526 7 3 5 3.0 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC(C)(C)C)ccc32)cc1 10.1016/j.bmcl.2011.03.115
56594768 72499 0 None - 0 Human 8.3 pKi = 8.3 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 540 5 1 5 6.1 Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2ccc(Cl)cc12 10.1021/jm200808v
CHEMBL1834618 72499 0 None - 0 Human 8.3 pKi = 8.3 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 540 5 1 5 6.1 Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2ccc(Cl)cc12 10.1021/jm200808v
56594639 72494 0 None - 0 Human 6.4 pKi = 6.4 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 568 6 1 5 6.8 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-n2nc(-c3ccccc3)c3ccccc3c2=O)cc1 10.1021/jm200808v
CHEMBL1834613 72494 0 None - 0 Human 6.4 pKi = 6.4 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 568 6 1 5 6.8 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-n2nc(-c3ccccc3)c3ccccc3c2=O)cc1 10.1021/jm200808v
54586518 68964 0 None - 1 Human 6.4 pKi = 6.4 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 552 7 1 5 3.4 Cc1ccc(S(=O)(=O)N2CCN(C)C(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
CHEMBL1777963 68964 0 None - 1 Human 6.4 pKi = 6.4 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 552 7 1 5 3.4 Cc1ccc(S(=O)(=O)N2CCN(C)C(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
44569938 195678 0 None - 0 Human 6.3 pKi = 6.3 Functional
Antagonist activity at human cloned B1 receptor expressed in african green monkey COS7 cells by calcium mobilization assayAntagonist activity at human cloned B1 receptor expressed in african green monkey COS7 cells by calcium mobilization assay
ChEMBL 629 14 1 7 4.7 COc1cc(CN(CC(=O)NCc2ccccc2Cl)S(=O)(=O)c2ccc(CN3CCOCC3)cc2)ccc1OCC(C)C 10.1016/j.bmcl.2008.11.005
CHEMBL507546 195678 0 None - 0 Human 6.3 pKi = 6.3 Functional
Antagonist activity at human cloned B1 receptor expressed in african green monkey COS7 cells by calcium mobilization assayAntagonist activity at human cloned B1 receptor expressed in african green monkey COS7 cells by calcium mobilization assay
ChEMBL 629 14 1 7 4.7 COc1cc(CN(CC(=O)NCc2ccccc2Cl)S(=O)(=O)c2ccc(CN3CCOCC3)cc2)ccc1OCC(C)C 10.1016/j.bmcl.2008.11.005
25181411 196072 0 None - 0 Human 6.3 pKi = 6.3 Functional
Antagonist activity at human cloned B1 receptor expressed in african green monkey COS7 cells by calcium mobilization assayAntagonist activity at human cloned B1 receptor expressed in african green monkey COS7 cells by calcium mobilization assay
ChEMBL 587 14 1 6 5.0 COc1cc(CN(CC(=O)NCc2ccccc2Cl)S(=O)(=O)c2ccc(CN(C)C)cc2)ccc1OCC(C)C 10.1016/j.bmcl.2008.11.005
CHEMBL512111 196072 0 None - 0 Human 6.3 pKi = 6.3 Functional
Antagonist activity at human cloned B1 receptor expressed in african green monkey COS7 cells by calcium mobilization assayAntagonist activity at human cloned B1 receptor expressed in african green monkey COS7 cells by calcium mobilization assay
ChEMBL 587 14 1 6 5.0 COc1cc(CN(CC(=O)NCc2ccccc2Cl)S(=O)(=O)c2ccc(CN(C)C)cc2)ccc1OCC(C)C 10.1016/j.bmcl.2008.11.005
54584600 68966 0 None - 1 Human 8.3 pKi = 8.3 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 538 7 2 5 3.1 Cc1ccc(S(=O)(=O)N2CC(=O)NCC2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
CHEMBL1777965 68966 0 None - 1 Human 8.3 pKi = 8.3 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 538 7 2 5 3.1 Cc1ccc(S(=O)(=O)N2CC(=O)NCC2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
54581664 68961 0 None - 1 Human 8.3 pKi = 8.3 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 538 7 2 5 3.1 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
CHEMBL1777960 68961 0 None - 1 Human 8.3 pKi = 8.3 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 538 7 2 5 3.1 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
56594505 72660 0 None - 0 Human 7.3 pKi = 7.3 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 492 5 1 5 5.2 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-n2ncc3ccccc3c2=O)cc1 10.1021/jm200808v
CHEMBL1835766 72660 0 None - 0 Human 7.3 pKi = 7.3 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 492 5 1 5 5.2 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-n2ncc3ccccc3c2=O)cc1 10.1021/jm200808v
54583583 68946 0 None - 1 Human 6.3 pKi = 6.3 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 462 6 2 5 1.3 CS(=O)(=O)N1CCNC(=O)C1CC(=O)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2011.03.115
CHEMBL1777880 68946 0 None - 1 Human 6.3 pKi = 6.3 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 462 6 2 5 1.3 CS(=O)(=O)N1CCNC(=O)C1CC(=O)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2011.03.115
54587551 68962 0 None - 1 Human 6.3 pKi = 6.3 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 538 7 2 5 3.1 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@@H]2CC(=O)N[C@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
CHEMBL1777961 68962 0 None - 1 Human 6.3 pKi = 6.3 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 538 7 2 5 3.1 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@@H]2CC(=O)N[C@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
56668920 72649 0 None - 0 Human 6.3 pKi = 6.3 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 466 7 1 3 5.9 O=C(Cc1ccccc1)c1cccc(C(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)c1 10.1021/jm200808v
CHEMBL1835754 72649 0 None - 0 Human 6.3 pKi = 6.3 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 466 7 1 3 5.9 O=C(Cc1ccccc1)c1cccc(C(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)c1 10.1021/jm200808v
54585539 68974 0 None - 1 Human 7.2 pKi = 7.2 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 470 6 3 5 1.5 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN)ccc32)cc1 10.1016/j.bmcl.2011.03.115
CHEMBL1777973 68974 0 None - 1 Human 7.2 pKi = 7.2 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 470 6 3 5 1.5 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN)ccc32)cc1 10.1016/j.bmcl.2011.03.115
56594504 72659 0 None - 0 Human 6.2 pKi = 6.2 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 492 5 1 5 5.2 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-n2cnc3ccccc3c2=O)cc1 10.1021/jm200808v
CHEMBL1835765 72659 0 None - 0 Human 6.2 pKi = 6.2 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 492 5 1 5 5.2 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-n2cnc3ccccc3c2=O)cc1 10.1021/jm200808v
11546560 80711 0 None - 0 Human 7.2 pKi = 7.2 Functional
Antagonist activity at Bradykinin B1 receptorAntagonist activity at Bradykinin B1 receptor
ChEMBL 434 7 2 4 3.4 COC(=O)c1ccccc1-c1ccc(CNC(=O)C2(NC(=O)CC(F)(F)F)CC2)cc1 10.1021/jm1013693
CHEMBL202089 80711 0 None - 0 Human 7.2 pKi = 7.2 Functional
Antagonist activity at Bradykinin B1 receptorAntagonist activity at Bradykinin B1 receptor
ChEMBL 434 7 2 4 3.4 COC(=O)c1ccccc1-c1ccc(CNC(=O)C2(NC(=O)CC(F)(F)F)CC2)cc1 10.1021/jm1013693
56594373 72657 0 None - 1 Human 5.2 pKi = 5.2 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 506 5 1 5 5.5 Cc1nn(-c2cccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)c2)c(=O)c2ccccc12 10.1021/jm200808v
CHEMBL1835762 72657 0 None - 1 Human 5.2 pKi = 5.2 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 506 5 1 5 5.5 Cc1nn(-c2cccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)c2)c(=O)c2ccccc12 10.1021/jm200808v
56594241 72651 0 None 4 2 Human 7.2 pKi = 7.2 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 492 5 1 4 6.3 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3ccccc3c2=O)c1 10.1021/jm200808v
CHEMBL1835756 72651 0 None 4 2 Human 7.2 pKi = 7.2 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 492 5 1 4 6.3 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3ccccc3c2=O)c1 10.1021/jm200808v
56594771 72554 0 None 2 2 Human 7.2 pKi = 7.2 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 507 5 1 6 4.9 Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2cccnc12 10.1021/jm200808v
CHEMBL1834749 72554 0 None 2 2 Human 7.2 pKi = 7.2 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 507 5 1 6 4.9 Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2cccnc12 10.1021/jm200808v
54581665 68965 0 None - 0 Human 6.1 pKi = 6.1 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 552 7 2 5 3.4 Cc1ccc(S(=O)(=O)N2CCNC(=O)C2(C)CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
CHEMBL1777964 68965 0 None - 0 Human 6.1 pKi = 6.1 Functional
Antagonist activity at human bradykinin B1 receptorAntagonist activity at human bradykinin B1 receptor
ChEMBL 552 7 2 5 3.4 Cc1ccc(S(=O)(=O)N2CCNC(=O)C2(C)CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2011.03.115
44411297 84136 0 None - 0 Human 6.1 pKi = 6.1 Functional
Antagonist activity at human bradykinin B1 receptor expressed in human HEK293 cells assessed as calcium flux by FLIPR assayAntagonist activity at human bradykinin B1 receptor expressed in human HEK293 cells assessed as calcium flux by FLIPR assay
ChEMBL 354 5 1 4 4.4 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccccn2)c(F)c1 10.1021/jm200371q
CHEMBL208538 84136 0 None - 0 Human 6.1 pKi = 6.1 Functional
Antagonist activity at human bradykinin B1 receptor expressed in human HEK293 cells assessed as calcium flux by FLIPR assayAntagonist activity at human bradykinin B1 receptor expressed in human HEK293 cells assessed as calcium flux by FLIPR assay
ChEMBL 354 5 1 4 4.4 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccccn2)c(F)c1 10.1021/jm200371q
56594508 72663 0 None - 0 Human 7.0 pKi = 7.0 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 560 5 1 5 6.2 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-n2nc(C(F)(F)F)c3ccccc3c2=O)cc1 10.1021/jm200808v
CHEMBL1835769 72663 0 None - 0 Human 7.0 pKi = 7.0 Functional
Antagonist activity at human B1 receptorAntagonist activity at human B1 receptor
ChEMBL 560 5 1 5 6.2 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-n2nc(C(F)(F)F)c3ccccc3c2=O)cc1 10.1021/jm200808v
653 7353 0 None -199 3 Mouse 6.1 pA2 = 6.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9650825
123884 9086 14 None - 1 Mouse 6.9 pA2 = 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8834490
641 9086 14 None - 1 Mouse 6.9 pA2 = 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8834490
CHEMBL80472 9086 14 None - 1 Mouse 6.9 pA2 = 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8834490
642 9088 19 None -2 2 Mouse 7.0 pA2 = 7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8834490
CHEMBL384721 9088 19 None -2 2 Mouse 7.0 pA2 = 7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8834490
661 10052 0 None -31 2 Mouse 7.0 pA2 = 7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8834490
663 8159 0 None - 1 Mouse 7.2 pA2 = 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9650825
653 7353 0 None -5 3 Human 7.7 pA2 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9650825
661 10052 0 None 31 2 Human 8.5 pA2 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8901831
101865250 10053 0 None - 1 Human 8.6 pA2 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None NCCC[C@@H](C(=O)N[C@H](C(=O)N1[C@H]2CCCC[C@H]2C[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@@H]([C@H](CC)C)C(=O)O)Cc1ccc2c(c1)cccc2)CO)(Cc1ccccc1)C)CCCN=C(N)N)NC(=O)C 24361511
3906 10053 0 None - 1 Human 8.6 pA2 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None NCCC[C@@H](C(=O)N[C@H](C(=O)N1[C@H]2CCCC[C@H]2C[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@@H]([C@H](CC)C)C(=O)O)Cc1ccc2c(c1)cccc2)CO)(Cc1ccccc1)C)CCCN=C(N)N)NC(=O)C 24361511
654 7354 0 None - 1 Human 9.2 pA2 = 9.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9650825
123884 9086 14 None - 1 Mouse 7.3 pEC50 None 7.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9276157
641 9086 14 None - 1 Mouse 7.3 pEC50 None 7.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9276157
CHEMBL80472 9086 14 None - 1 Mouse 7.3 pEC50 None 7.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9276157
642 9088 19 None 2 2 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8063797
CHEMBL384721 9088 19 None 2 2 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8063797
10254 9591 0 None - 1 Human 9.5 pIC50 = 9.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 26565554
3035449 9294 0 None -39 3 Human 7.1 pIC50 None 7.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8063797
638 9294 0 None -39 3 Human 7.1 pIC50 None 7.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8063797
16108961 7710 0 None -2 3 Rat 8.4 pIC50 None 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 583 9 2 5 5.9 O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 17243660
664 7710 0 None -2 3 Rat 8.4 pIC50 None 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 583 9 2 5 5.9 O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 17243660
CHEMBL415848 7710 0 None -2 3 Rat 8.4 pIC50 None 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 583 9 2 5 5.9 O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 17243660
16108961 7710 0 None 2 3 Human 8.5 pIC50 None 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 583 9 2 5 5.9 O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 17243660
664 7710 0 None 2 3 Human 8.5 pIC50 None 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 583 9 2 5 5.9 O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 17243660
CHEMBL415848 7710 0 None 2 3 Human 8.5 pIC50 None 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 583 9 2 5 5.9 O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 17243660




Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
Sel. page Similar-
ity
Common
name
GPCRdb
ID
#Vendors

Reference
ligand
Fold
selectivity
# Tested
GPCRs
Species

p-value
(-log)
Activity
Type
Activity
Relation
Activity
Value
Assay
Type
Assay
Description
Source

Mol
weight
Rot
Bonds
H don

H acc

LogP

Smiles

DOI

135398735 143746 32 None - 0 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human BDKRB1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human BDKRB1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 822 4 6 15 4.3 CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C 10.1038/s41467-023-40064-9
136262914 143746 32 None - 0 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human BDKRB1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human BDKRB1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 822 4 6 15 4.3 CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C 10.1038/s41467-023-40064-9
CHEMBL374478 143746 32 None - 0 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human BDKRB1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human BDKRB1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 822 4 6 15 4.3 CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C 10.1038/s41467-023-40064-9
644241 101961 121 None - 0 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human BDKRB1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human BDKRB1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 529 6 2 7 6.4 Cc1cn(-c2cc(NC(=O)c3ccc(C)c(Nc4nccc(-c5cccnc5)n4)c3)cc(C(F)(F)F)c2)cn1 10.1038/s41467-023-40064-9
CHEMBL255863 101961 121 None - 0 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human BDKRB1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human BDKRB1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 529 6 2 7 6.4 Cc1cn(-c2cc(NC(=O)c3ccc(C)c(Nc4nccc(-c5cccnc5)n4)c3)cc(C(F)(F)F)c2)cn1 10.1038/s41467-023-40064-9
665 7760 3 None - 2 Rabbit 9.6 pIC50 = 9.6 Binding
Inhibition of rabbit bradykinin B1 receptorInhibition of rabbit bradykinin B1 receptor
ChEMBL 585 8 3 6 3.6 O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 10.1021/jm1000776
9916412 7760 3 None - 2 Rabbit 9.6 pIC50 = 9.6 Binding
Inhibition of rabbit bradykinin B1 receptorInhibition of rabbit bradykinin B1 receptor
ChEMBL 585 8 3 6 3.6 O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 10.1021/jm1000776
CHEMBL189123 7760 3 None - 2 Rabbit 9.6 pIC50 = 9.6 Binding
Inhibition of rabbit bradykinin B1 receptorInhibition of rabbit bradykinin B1 receptor
ChEMBL 585 8 3 6 3.6 O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 10.1021/jm1000776
122227 8160 31 None 6 3 Human 9.1 pIC50 = 9.1 Binding
Displacement of [3H](Des-Arg10)-Kallidin from bradykinin B1 receptor in human IMR90 cells after 60 minsDisplacement of [3H](Des-Arg10)-Kallidin from bradykinin B1 receptor in human IMR90 cells after 60 mins
ChEMBL None None None None 10.1016/j.bmcl.2013.01.025
3825 8160 31 None 6 3 Human 9.1 pIC50 = 9.1 Binding
Displacement of [3H](Des-Arg10)-Kallidin from bradykinin B1 receptor in human IMR90 cells after 60 minsDisplacement of [3H](Des-Arg10)-Kallidin from bradykinin B1 receptor in human IMR90 cells after 60 mins
ChEMBL None None None None 10.1016/j.bmcl.2013.01.025
644 8160 31 None 6 3 Human 9.1 pIC50 = 9.1 Binding
Displacement of [3H](Des-Arg10)-Kallidin from bradykinin B1 receptor in human IMR90 cells after 60 minsDisplacement of [3H](Des-Arg10)-Kallidin from bradykinin B1 receptor in human IMR90 cells after 60 mins
ChEMBL None None None None 10.1016/j.bmcl.2013.01.025
CHEMBL264100 8160 31 None 6 3 Human 9.1 pIC50 = 9.1 Binding
Displacement of [3H](Des-Arg10)-Kallidin from bradykinin B1 receptor in human IMR90 cells after 60 minsDisplacement of [3H](Des-Arg10)-Kallidin from bradykinin B1 receptor in human IMR90 cells after 60 mins
ChEMBL None None None None 10.1016/j.bmcl.2013.01.025
44579694 199922 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of human bradykinin B1 receptorInhibition of human bradykinin B1 receptor
ChEMBL 486 7 3 5 3.6 Cc1c(C(=O)NCCC2CCN(C3CCN(C)CC3)CC2)n[nH]c1NC(=O)c1ccccc1Cl 10.1016/j.bmcl.2008.08.014
CHEMBL522947 199922 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of human bradykinin B1 receptorInhibition of human bradykinin B1 receptor
ChEMBL 486 7 3 5 3.6 Cc1c(C(=O)NCCC2CCN(C3CCN(C)CC3)CC2)n[nH]c1NC(=O)c1ccccc1Cl 10.1016/j.bmcl.2008.08.014
10031511 23718 0 None 1 2 Human 8.7 pIC50 = 8.7 Binding
Compound was tested for inhibition against human bradykinin B1 receptor using FLIPR assayCompound was tested for inhibition against human bradykinin B1 receptor using FLIPR assay
ChEMBL 601 9 2 6 5.7 CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCN(c4ccncc4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 10.1021/jm034020y
CHEMBL1253497 23718 0 None 1 2 Human 8.7 pIC50 = 8.7 Binding
Compound was tested for inhibition against human bradykinin B1 receptor using FLIPR assayCompound was tested for inhibition against human bradykinin B1 receptor using FLIPR assay
ChEMBL 601 9 2 6 5.7 CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCN(c4ccncc4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 10.1021/jm034020y
11204003 83996 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of human B1 receptorInhibition of human B1 receptor
ChEMBL 579 7 2 4 6.0 Cc1ccc(S(=O)(=O)N2CCCC[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC(C)(C)C)ccc32)cc1C(F)(F)F 10.1016/j.bmcl.2006.01.069
CHEMBL207947 83996 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of human B1 receptorInhibition of human B1 receptor
ChEMBL 579 7 2 4 6.0 Cc1ccc(S(=O)(=O)N2CCCC[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC(C)(C)C)ccc32)cc1C(F)(F)F 10.1016/j.bmcl.2006.01.069
44410020 144998 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of human B1 receptorInhibition of human B1 receptor
ChEMBL 549 7 1 4 5.0 O=C(C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCCc2cc(CN3CCC3)ccc21 10.1016/j.bmcl.2006.01.069
CHEMBL377011 144998 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of human B1 receptorInhibition of human B1 receptor
ChEMBL 549 7 1 4 5.0 O=C(C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCCc2cc(CN3CCC3)ccc21 10.1016/j.bmcl.2006.01.069
44410316 147641 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of human B1 receptorInhibition of human B1 receptor
ChEMBL 531 7 2 4 5.4 CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(Cl)c1 10.1016/j.bmcl.2006.01.069
CHEMBL381964 147641 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of human B1 receptorInhibition of human B1 receptor
ChEMBL 531 7 2 4 5.4 CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(Cl)c1 10.1016/j.bmcl.2006.01.069
44410269 172913 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of human B1 receptorInhibition of human B1 receptor
ChEMBL 569 11 2 5 5.9 CCCCOc1ccc(S(=O)(=O)N2CCCC[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC(C)(C)C)ccc32)cc1 10.1016/j.bmcl.2006.01.069
CHEMBL426130 172913 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of human B1 receptorInhibition of human B1 receptor
ChEMBL 569 11 2 5 5.9 CCCCOc1ccc(S(=O)(=O)N2CCCC[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC(C)(C)C)ccc32)cc1 10.1016/j.bmcl.2006.01.069
11215189 175572 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of human B1 receptorInhibition of human B1 receptor
ChEMBL 565 9 2 4 5.6 CC(C)CNCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2006.01.069
CHEMBL437509 175572 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of human B1 receptorInhibition of human B1 receptor
ChEMBL 565 9 2 4 5.6 CC(C)CNCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2006.01.069
11444270 83494 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of human B1 receptorInhibition of human B1 receptor
ChEMBL 553 7 2 5 5.9 CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1csc2ccccc12 10.1016/j.bmcl.2006.01.069
CHEMBL206554 83494 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of human B1 receptorInhibition of human B1 receptor
ChEMBL 553 7 2 5 5.9 CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1csc2ccccc12 10.1016/j.bmcl.2006.01.069
11444165 147657 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of human B1 receptorInhibition of human B1 receptor
ChEMBL 545 7 2 4 5.7 Cc1ccc(S(=O)(=O)N2CCCC[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC(C)(C)C)ccc32)cc1Cl 10.1016/j.bmcl.2006.01.069
CHEMBL381979 147657 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of human B1 receptorInhibition of human B1 receptor
ChEMBL 545 7 2 4 5.7 Cc1ccc(S(=O)(=O)N2CCCC[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC(C)(C)C)ccc32)cc1Cl 10.1016/j.bmcl.2006.01.069
11512379 172784 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of human B1 receptorInhibition of human B1 receptor
ChEMBL 555 7 2 7 4.7 CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2006.01.069
CHEMBL425416 172784 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of human B1 receptorInhibition of human B1 receptor
ChEMBL 555 7 2 7 4.7 CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2006.01.069
44410368 83536 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of human B1 receptorInhibition of human B1 receptor
ChEMBL 553 7 2 5 4.8 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1CCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2006.01.069
CHEMBL206801 83536 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of human B1 receptorInhibition of human B1 receptor
ChEMBL 553 7 2 5 4.8 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1CCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2006.01.069
11203826 146900 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of human B1 receptorInhibition of human B1 receptor
ChEMBL 563 9 2 4 5.3 O=C(C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCCc2cc(CNCC3CC3)ccc21 10.1016/j.bmcl.2006.01.069
CHEMBL380117 146900 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of human B1 receptorInhibition of human B1 receptor
ChEMBL 563 9 2 4 5.3 O=C(C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCCc2cc(CNCC3CC3)ccc21 10.1016/j.bmcl.2006.01.069
44410026 83571 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of human B1 receptorInhibition of human B1 receptor
ChEMBL 567 7 2 5 5.2 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2006.01.069
CHEMBL206901 83571 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of human B1 receptorInhibition of human B1 receptor
ChEMBL 567 7 2 5 5.2 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2006.01.069
665 7760 3 None -1023 2 Rat 6.8 pIC50 = 6.8 Binding
Inhibition of rat bradykinin B1 receptorInhibition of rat bradykinin B1 receptor
ChEMBL 585 8 3 6 3.6 O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 10.1021/jm1000776
9916412 7760 3 None -1023 2 Rat 6.8 pIC50 = 6.8 Binding
Inhibition of rat bradykinin B1 receptorInhibition of rat bradykinin B1 receptor
ChEMBL 585 8 3 6 3.6 O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 10.1021/jm1000776
CHEMBL189123 7760 3 None -1023 2 Rat 6.8 pIC50 = 6.8 Binding
Inhibition of rat bradykinin B1 receptorInhibition of rat bradykinin B1 receptor
ChEMBL 585 8 3 6 3.6 O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 10.1021/jm1000776
10187347 200139 0 None - 1 Human 6.8 pIC50 = 6.8 Binding
Compound was tested for inhibition against human bradykinin B1 receptor using FLIPR assayCompound was tested for inhibition against human bradykinin B1 receptor using FLIPR assay
ChEMBL 544 7 2 5 5.5 CCCN1C(=O)C(NC(=O)Nc2ccc(N3CCC(N(C)C)CC3)cc2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm034020y
CHEMBL52498 200139 0 None - 1 Human 6.8 pIC50 = 6.8 Binding
Compound was tested for inhibition against human bradykinin B1 receptor using FLIPR assayCompound was tested for inhibition against human bradykinin B1 receptor using FLIPR assay
ChEMBL 544 7 2 5 5.5 CCCN1C(=O)C(NC(=O)Nc2ccc(N3CCC(N(C)C)CC3)cc2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm034020y
44410143 84111 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of human B1 receptorInhibition of human B1 receptor
ChEMBL 497 7 2 4 4.7 CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1ccccc1 10.1016/j.bmcl.2006.01.069
CHEMBL208386 84111 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of human B1 receptorInhibition of human B1 receptor
ChEMBL 497 7 2 4 4.7 CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1ccccc1 10.1016/j.bmcl.2006.01.069
44410084 83705 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of human B1 receptorInhibition of human B1 receptor
ChEMBL 591 8 2 4 5.5 O=C(C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCCc2cc(CNCC(F)(F)F)ccc21 10.1016/j.bmcl.2006.01.069
CHEMBL207033 83705 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of human B1 receptorInhibition of human B1 receptor
ChEMBL 591 8 2 4 5.5 O=C(C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCCc2cc(CNCC(F)(F)F)ccc21 10.1016/j.bmcl.2006.01.069
10031511 23718 0 None -1 2 Rat 8.6 pIC50 = 8.6 Binding
Compound was tested for inhibition against rat Bradykinin receptor B1 using FLIPR assayCompound was tested for inhibition against rat Bradykinin receptor B1 using FLIPR assay
ChEMBL 601 9 2 6 5.7 CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCN(c4ccncc4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 10.1021/jm034020y
CHEMBL1253497 23718 0 None -1 2 Rat 8.6 pIC50 = 8.6 Binding
Compound was tested for inhibition against rat Bradykinin receptor B1 using FLIPR assayCompound was tested for inhibition against rat Bradykinin receptor B1 using FLIPR assay
ChEMBL 601 9 2 6 5.7 CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCN(c4ccncc4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 10.1021/jm034020y
10031511 23718 0 None -1 2 Rat 8.6 pIC50 = 8.6 Binding
Inhibition of rat bradykinin B1 receptorInhibition of rat bradykinin B1 receptor
ChEMBL 601 9 2 6 5.7 CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCN(c4ccncc4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 10.1021/jm1000776
CHEMBL1253497 23718 0 None -1 2 Rat 8.6 pIC50 = 8.6 Binding
Inhibition of rat bradykinin B1 receptorInhibition of rat bradykinin B1 receptor
ChEMBL 601 9 2 6 5.7 CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCN(c4ccncc4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 10.1021/jm1000776
11478613 147369 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of human B1 receptorInhibition of human B1 receptor
ChEMBL 567 10 2 5 4.6 COCCNCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2006.01.069
CHEMBL381372 147369 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of human B1 receptorInhibition of human B1 receptor
ChEMBL 567 10 2 5 4.6 COCCNCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2006.01.069
44410250 82730 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of human B1 receptorInhibition of human B1 receptor
ChEMBL 548 7 2 5 5.3 CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc2cccnc12 10.1016/j.bmcl.2006.01.069
CHEMBL205227 82730 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of human B1 receptorInhibition of human B1 receptor
ChEMBL 548 7 2 5 5.3 CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc2cccnc12 10.1016/j.bmcl.2006.01.069
10875606 69847 0 None - 1 Human 5.7 pIC50 = 5.7 Binding
Compound was tested for inhibition against human bradykinin B1 receptor using FLIPR assayCompound was tested for inhibition against human bradykinin B1 receptor using FLIPR assay
ChEMBL 584 7 2 5 6.4 CCCN1C(=O)[C@@H](NC(=O)Nc2ccc(N3CCC(N4CCCCC4)CC3)cc2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm034020y
CHEMBL1788318 69847 0 None - 1 Human 5.7 pIC50 = 5.7 Binding
Compound was tested for inhibition against human bradykinin B1 receptor using FLIPR assayCompound was tested for inhibition against human bradykinin B1 receptor using FLIPR assay
ChEMBL 584 7 2 5 6.4 CCCN1C(=O)[C@@H](NC(=O)Nc2ccc(N3CCC(N4CCCCC4)CC3)cc2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm034020y
11284458 147366 2 None - 1 Human 7.6 pIC50 = 7.6 Binding
Inhibition of human B1 receptorInhibition of human B1 receptor
ChEMBL 565 7 2 4 5.7 CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2006.01.069
CHEMBL381366 147366 2 None - 1 Human 7.6 pIC50 = 7.6 Binding
Inhibition of human B1 receptorInhibition of human B1 receptor
ChEMBL 565 7 2 4 5.7 CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2006.01.069
11017305 67101 0 None - 1 Rat 7.6 pIC50 = 7.6 Binding
Compound was tested for inhibition against rat Bradykinin receptor B1 using FLIPR assayCompound was tested for inhibition against rat Bradykinin receptor B1 using FLIPR assay
ChEMBL 579 7 2 6 5.7 CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCN(c4ccncc4)CC3)cc2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm034020y
CHEMBL1744084 67101 0 None - 1 Rat 7.6 pIC50 = 7.6 Binding
Compound was tested for inhibition against rat Bradykinin receptor B1 using FLIPR assayCompound was tested for inhibition against rat Bradykinin receptor B1 using FLIPR assay
ChEMBL 579 7 2 6 5.7 CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCN(c4ccncc4)CC3)cc2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm034020y
11071992 67099 0 None 3 2 Human 7.6 pIC50 = 7.6 Binding
Compound was tested for inhibition against human bradykinin B1 receptor using FLIPR assayCompound was tested for inhibition against human bradykinin B1 receptor using FLIPR assay
ChEMBL 584 7 2 5 6.4 CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCC(N4CCCCC4)CC3)cc2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm034020y
CHEMBL1744082 67099 0 None 3 2 Human 7.6 pIC50 = 7.6 Binding
Compound was tested for inhibition against human bradykinin B1 receptor using FLIPR assayCompound was tested for inhibition against human bradykinin B1 receptor using FLIPR assay
ChEMBL 584 7 2 5 6.4 CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCC(N4CCCCC4)CC3)cc2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm034020y
11039234 67102 0 None -1 2 Rat 7.6 pIC50 = 7.6 Binding
Compound was tested for inhibition against rat Bradykinin receptor B1 using FLIPR assayCompound was tested for inhibition against rat Bradykinin receptor B1 using FLIPR assay
ChEMBL 592 7 2 5 6.2 CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCC(N4CCCCC4)CC3)cc2)N=C(c2ccc(C)cc2)c2ccccc21 10.1021/jm034020y
CHEMBL1744085 67102 0 None -1 2 Rat 7.6 pIC50 = 7.6 Binding
Compound was tested for inhibition against rat Bradykinin receptor B1 using FLIPR assayCompound was tested for inhibition against rat Bradykinin receptor B1 using FLIPR assay
ChEMBL 592 7 2 5 6.2 CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCC(N4CCCCC4)CC3)cc2)N=C(c2ccc(C)cc2)c2ccccc21 10.1021/jm034020y
44455075 102127 0 None - 1 Human 8.4 pIC50 = 8.4 Binding
Binding affinity to human bradykinin B1 receptor by FLIPR assayBinding affinity to human bradykinin B1 receptor by FLIPR assay
ChEMBL 482 5 2 5 4.5 COC(=O)c1c(Cl)cc(Cl)cc1-c1cnc([C@@H](C)NC(=O)[C@@](C)(O)C(F)(F)F)c(F)c1 10.1016/j.bmcl.2007.11.050
CHEMBL256671 102127 0 None - 1 Human 8.4 pIC50 = 8.4 Binding
Binding affinity to human bradykinin B1 receptor by FLIPR assayBinding affinity to human bradykinin B1 receptor by FLIPR assay
ChEMBL 482 5 2 5 4.5 COC(=O)c1c(Cl)cc(Cl)cc1-c1cnc([C@@H](C)NC(=O)[C@@](C)(O)C(F)(F)F)c(F)c1 10.1016/j.bmcl.2007.11.050
44410186 83992 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of human B1 receptorInhibition of human B1 receptor
ChEMBL 615 8 2 4 6.4 CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1ccc(C(F)(F)C(F)(F)F)cc1 10.1016/j.bmcl.2006.01.069
CHEMBL207945 83992 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of human B1 receptorInhibition of human B1 receptor
ChEMBL 615 8 2 4 6.4 CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1ccc(C(F)(F)C(F)(F)F)cc1 10.1016/j.bmcl.2006.01.069
16726096 162047 9 None 2 4 Human 8.4 pIC50 = 8.4 Binding
Binding affinity to human bradykinin B1 receptor by FLIPR assayBinding affinity to human bradykinin B1 receptor by FLIPR assay
ChEMBL 490 5 2 6 4.5 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)[C@@](C)(O)C(F)(F)F)c(F)c2)no1 10.1016/j.bmcl.2007.11.050
CHEMBL402831 162047 9 None 2 4 Human 8.4 pIC50 = 8.4 Binding
Binding affinity to human bradykinin B1 receptor by FLIPR assayBinding affinity to human bradykinin B1 receptor by FLIPR assay
ChEMBL 490 5 2 6 4.5 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)[C@@](C)(O)C(F)(F)F)c(F)c2)no1 10.1016/j.bmcl.2007.11.050
11050306 67100 0 None 1 2 Human 8.3 pIC50 = 8.3 Binding
Compound was tested for inhibition against human bradykinin B1 receptor using FLIPR assayCompound was tested for inhibition against human bradykinin B1 receptor using FLIPR assay
ChEMBL 606 9 2 5 6.5 CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCC(N4CCCCC4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 10.1021/jm034020y
CHEMBL1744083 67100 0 None 1 2 Human 8.3 pIC50 = 8.3 Binding
Compound was tested for inhibition against human bradykinin B1 receptor using FLIPR assayCompound was tested for inhibition against human bradykinin B1 receptor using FLIPR assay
ChEMBL 606 9 2 5 6.5 CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCC(N4CCCCC4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 10.1021/jm034020y
44455035 102499 0 None - 1 Human 8.3 pIC50 = 8.3 Binding
Binding affinity to human bradykinin B1 receptor by FLIPR assayBinding affinity to human bradykinin B1 receptor by FLIPR assay
ChEMBL 490 5 2 7 3.4 C[C@@H](NC(=O)[C@@](C)(O)C(F)(F)F)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F 10.1016/j.bmcl.2007.11.050
CHEMBL258324 102499 0 None - 1 Human 8.3 pIC50 = 8.3 Binding
Binding affinity to human bradykinin B1 receptor by FLIPR assayBinding affinity to human bradykinin B1 receptor by FLIPR assay
ChEMBL 490 5 2 7 3.4 C[C@@H](NC(=O)[C@@](C)(O)C(F)(F)F)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F 10.1016/j.bmcl.2007.11.050
44455108 161923 0 None - 1 Human 7.4 pIC50 = 7.4 Binding
Binding affinity to human bradykinin B1 receptor by FLIPR assayBinding affinity to human bradykinin B1 receptor by FLIPR assay
ChEMBL 417 5 2 4 3.3 COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)[C@@](C)(O)C(F)(F)F)c(F)c1 10.1016/j.bmcl.2007.11.050
CHEMBL402114 161923 0 None - 1 Human 7.4 pIC50 = 7.4 Binding
Binding affinity to human bradykinin B1 receptor by FLIPR assayBinding affinity to human bradykinin B1 receptor by FLIPR assay
ChEMBL 417 5 2 4 3.3 COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)[C@@](C)(O)C(F)(F)F)c(F)c1 10.1016/j.bmcl.2007.11.050
11330286 83245 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of human B1 receptorInhibition of human B1 receptor
ChEMBL 549 8 2 4 5.1 O=C(C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCCc2cc(CNC3CC3)ccc21 10.1016/j.bmcl.2006.01.069
CHEMBL205981 83245 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of human B1 receptorInhibition of human B1 receptor
ChEMBL 549 8 2 4 5.1 O=C(C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCCc2cc(CNC3CC3)ccc21 10.1016/j.bmcl.2006.01.069
44410273 83490 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of human B1 receptorInhibition of human B1 receptor
ChEMBL 531 7 2 4 5.4 CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1ccc(Cl)cc1 10.1016/j.bmcl.2006.01.069
CHEMBL206541 83490 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of human B1 receptorInhibition of human B1 receptor
ChEMBL 531 7 2 4 5.4 CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1ccc(Cl)cc1 10.1016/j.bmcl.2006.01.069
11238372 175819 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of human B1 receptorInhibition of human B1 receptor
ChEMBL 563 8 2 4 5.5 O=C(C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCCc2cc(CNC3CCC3)ccc21 10.1016/j.bmcl.2006.01.069
CHEMBL439505 175819 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of human B1 receptorInhibition of human B1 receptor
ChEMBL 563 8 2 4 5.5 O=C(C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCCc2cc(CNC3CCC3)ccc21 10.1016/j.bmcl.2006.01.069
11071992 67099 0 None -3 2 Rat 7.2 pIC50 = 7.2 Binding
Compound was tested for inhibition against rat Bradykinin receptor B1 using FLIPR assayCompound was tested for inhibition against rat Bradykinin receptor B1 using FLIPR assay
ChEMBL 584 7 2 5 6.4 CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCC(N4CCCCC4)CC3)cc2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm034020y
CHEMBL1744082 67099 0 None -3 2 Rat 7.2 pIC50 = 7.2 Binding
Compound was tested for inhibition against rat Bradykinin receptor B1 using FLIPR assayCompound was tested for inhibition against rat Bradykinin receptor B1 using FLIPR assay
ChEMBL 584 7 2 5 6.4 CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCC(N4CCCCC4)CC3)cc2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm034020y
11307733 81671 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of human B1 receptorInhibition of human B1 receptor
ChEMBL 579 8 2 4 6.0 CC(C)(C)CNCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2006.01.069
CHEMBL203174 81671 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of human B1 receptorInhibition of human B1 receptor
ChEMBL 579 8 2 4 6.0 CC(C)(C)CNCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2006.01.069
44455073 102361 0 None - 1 Human 8.2 pIC50 = 8.2 Binding
Binding affinity to human bradykinin B1 receptor by FLIPR assayBinding affinity to human bradykinin B1 receptor by FLIPR assay
ChEMBL 506 5 2 6 5.0 Cc1noc(-c2c(Cl)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)[C@@](C)(O)C(F)(F)F)c(F)c2)n1 10.1016/j.bmcl.2007.11.050
CHEMBL257729 102361 0 None - 1 Human 8.2 pIC50 = 8.2 Binding
Binding affinity to human bradykinin B1 receptor by FLIPR assayBinding affinity to human bradykinin B1 receptor by FLIPR assay
ChEMBL 506 5 2 6 5.0 Cc1noc(-c2c(Cl)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)[C@@](C)(O)C(F)(F)F)c(F)c2)n1 10.1016/j.bmcl.2007.11.050
44455038 102500 0 None - 1 Human 8.2 pIC50 = 8.2 Binding
Binding affinity to human bradykinin B1 receptor by FLIPR assayBinding affinity to human bradykinin B1 receptor by FLIPR assay
ChEMBL 490 5 2 6 4.5 Cc1noc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)[C@@](C)(O)C(F)(F)F)c(F)c2)n1 10.1016/j.bmcl.2007.11.050
CHEMBL258326 102500 0 None - 1 Human 8.2 pIC50 = 8.2 Binding
Binding affinity to human bradykinin B1 receptor by FLIPR assayBinding affinity to human bradykinin B1 receptor by FLIPR assay
ChEMBL 490 5 2 6 4.5 Cc1noc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)[C@@](C)(O)C(F)(F)F)c(F)c2)n1 10.1016/j.bmcl.2007.11.050
44410254 82733 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of human B1 receptorInhibition of human B1 receptor
ChEMBL 548 7 2 5 5.3 CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc2cnccc12 10.1016/j.bmcl.2006.01.069
CHEMBL205242 82733 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of human B1 receptorInhibition of human B1 receptor
ChEMBL 548 7 2 5 5.3 CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc2cnccc12 10.1016/j.bmcl.2006.01.069
44410328 82780 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of human B1 receptorInhibition of human B1 receptor
ChEMBL 537 7 1 4 4.9 CN(C)Cc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2006.01.069
CHEMBL205501 82780 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of human B1 receptorInhibition of human B1 receptor
ChEMBL 537 7 1 4 4.9 CN(C)Cc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2006.01.069
11284303 73116 0 None -2 2 Human 5.2 pIC50 = 5.2 Binding
Inhibition of Bradykinin receptor B1 expressed in HEK293 cellsInhibition of Bradykinin receptor B1 expressed in HEK293 cells
ChEMBL 553 15 1 7 4.7 CN(C)CCCN(CCCN(C)C)S(=O)(=O)c1ccc(NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 10.1021/jm049747g
CHEMBL185068 73116 0 None -2 2 Human 5.2 pIC50 = 5.2 Binding
Inhibition of Bradykinin receptor B1 expressed in HEK293 cellsInhibition of Bradykinin receptor B1 expressed in HEK293 cells
ChEMBL 553 15 1 7 4.7 CN(C)CCCN(CCCN(C)C)S(=O)(=O)c1ccc(NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 10.1021/jm049747g
11039234 67102 0 None 1 2 Human 7.2 pIC50 = 7.2 Binding
Compound was tested for inhibition against human bradykinin B1 receptor using FLIPR assayCompound was tested for inhibition against human bradykinin B1 receptor using FLIPR assay
ChEMBL 592 7 2 5 6.2 CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCC(N4CCCCC4)CC3)cc2)N=C(c2ccc(C)cc2)c2ccccc21 10.1021/jm034020y
CHEMBL1744085 67102 0 None 1 2 Human 7.2 pIC50 = 7.2 Binding
Compound was tested for inhibition against human bradykinin B1 receptor using FLIPR assayCompound was tested for inhibition against human bradykinin B1 receptor using FLIPR assay
ChEMBL 592 7 2 5 6.2 CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCC(N4CCCCC4)CC3)cc2)N=C(c2ccc(C)cc2)c2ccccc21 10.1021/jm034020y
44410179 173095 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of human B1 receptorInhibition of human B1 receptor
ChEMBL 573 8 2 4 6.4 CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2006.01.069
CHEMBL427208 173095 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of human B1 receptorInhibition of human B1 receptor
ChEMBL 573 8 2 4 6.4 CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2006.01.069
11050306 67100 0 None -1 2 Rat 8.1 pIC50 = 8.1 Binding
Compound was tested for inhibition against rat Bradykinin receptor B1 using FLIPR assayCompound was tested for inhibition against rat Bradykinin receptor B1 using FLIPR assay
ChEMBL 606 9 2 5 6.5 CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCC(N4CCCCC4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 10.1021/jm034020y
CHEMBL1744083 67100 0 None -1 2 Rat 8.1 pIC50 = 8.1 Binding
Compound was tested for inhibition against rat Bradykinin receptor B1 using FLIPR assayCompound was tested for inhibition against rat Bradykinin receptor B1 using FLIPR assay
ChEMBL 606 9 2 5 6.5 CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCC(N4CCCCC4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 10.1021/jm034020y
11214998 83330 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of human B1 receptorInhibition of human B1 receptor
ChEMBL 551 8 2 4 5.3 CC(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2006.01.069
CHEMBL206247 83330 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of human B1 receptorInhibition of human B1 receptor
ChEMBL 551 8 2 4 5.3 CC(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2006.01.069
44410313 82576 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of human B1 receptorInhibition of human B1 receptor
ChEMBL 527 8 2 5 4.7 COc1ccc(S(=O)(=O)N2CCCC[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC(C)(C)C)ccc32)cc1 10.1016/j.bmcl.2006.01.069
CHEMBL204847 82576 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of human B1 receptorInhibition of human B1 receptor
ChEMBL 527 8 2 5 4.7 COc1ccc(S(=O)(=O)N2CCCC[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC(C)(C)C)ccc32)cc1 10.1016/j.bmcl.2006.01.069
11017305 67101 0 None - 1 Human 8.1 pIC50 = 8.1 Binding
Compound was tested for inhibition against human bradykinin B1 receptor using FLIPR assayCompound was tested for inhibition against human bradykinin B1 receptor using FLIPR assay
ChEMBL 579 7 2 6 5.7 CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCN(c4ccncc4)CC3)cc2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm034020y
CHEMBL1744084 67101 0 None - 1 Human 8.1 pIC50 = 8.1 Binding
Compound was tested for inhibition against human bradykinin B1 receptor using FLIPR assayCompound was tested for inhibition against human bradykinin B1 receptor using FLIPR assay
ChEMBL 579 7 2 6 5.7 CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCN(c4ccncc4)CC3)cc2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm034020y
11420875 84112 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of human B1 receptorInhibition of human B1 receptor
ChEMBL 511 7 2 4 5.0 Cc1ccc(S(=O)(=O)N2CCCC[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC(C)(C)C)ccc32)cc1 10.1016/j.bmcl.2006.01.069
CHEMBL208387 84112 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of human B1 receptorInhibition of human B1 receptor
ChEMBL 511 7 2 4 5.0 Cc1ccc(S(=O)(=O)N2CCCC[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC(C)(C)C)ccc32)cc1 10.1016/j.bmcl.2006.01.069
11757682 128818 0 None 2 4 Human 10.8 pKd = 10.8 Binding
Equilibrium dissociation constant of the [35S]- radiolabeled compound against human Bradykinin receptor B1 expressed in CHO membranes was determinedEquilibrium dissociation constant of the [35S]- radiolabeled compound against human Bradykinin receptor B1 expressed in CHO membranes was determined
ChEMBL 567 8 3 6 3.5 O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc2ccccc2c1)NCCc1ccc(C2=NCCN2)cc1 10.1016/j.bmcl.2004.09.074
CHEMBL359553 128818 0 None 2 4 Human 10.8 pKd = 10.8 Binding
Equilibrium dissociation constant of the [35S]- radiolabeled compound against human Bradykinin receptor B1 expressed in CHO membranes was determinedEquilibrium dissociation constant of the [35S]- radiolabeled compound against human Bradykinin receptor B1 expressed in CHO membranes was determined
ChEMBL 567 8 3 6 3.5 O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc2ccccc2c1)NCCc1ccc(C2=NCCN2)cc1 10.1016/j.bmcl.2004.09.074
11444808 60729 0 None - 1 Human 11.0 pKi = 11 Binding
Binding affinity to human Bradykinin receptor B1 over-expressed in transgenic rats was determined by ex vivo receptor occupancy assayBinding affinity to human Bradykinin receptor B1 over-expressed in transgenic rats was determined by ex vivo receptor occupancy assay
ChEMBL 601 8 3 6 4.1 O=C(C[C@@H]1C(=O)Nc2ccc(Cl)cc2N1S(=O)(=O)c1ccc2ccccc2c1)NCCc1ccc(C2=NCCN2)cc1 10.1016/j.bmcl.2004.09.074
CHEMBL160547 60729 0 None - 1 Human 11.0 pKi = 11 Binding
Binding affinity to human Bradykinin receptor B1 over-expressed in transgenic rats was determined by ex vivo receptor occupancy assayBinding affinity to human Bradykinin receptor B1 over-expressed in transgenic rats was determined by ex vivo receptor occupancy assay
ChEMBL 601 8 3 6 4.1 O=C(C[C@@H]1C(=O)Nc2ccc(Cl)cc2N1S(=O)(=O)c1ccc2ccccc2c1)NCCc1ccc(C2=NCCN2)cc1 10.1016/j.bmcl.2004.09.074
11757682 128818 0 None 2 4 Human 10.7 pKi = 10.7 Binding
Binding affinity of the [35S]- radiolabeled compound to human Bradykinin receptor B1 over-expressed in transgenic rats was determined by ex vivo receptor occupancy assayBinding affinity of the [35S]- radiolabeled compound to human Bradykinin receptor B1 over-expressed in transgenic rats was determined by ex vivo receptor occupancy assay
ChEMBL 567 8 3 6 3.5 O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc2ccccc2c1)NCCc1ccc(C2=NCCN2)cc1 10.1016/j.bmcl.2004.09.074
CHEMBL359553 128818 0 None 2 4 Human 10.7 pKi = 10.7 Binding
Binding affinity of the [35S]- radiolabeled compound to human Bradykinin receptor B1 over-expressed in transgenic rats was determined by ex vivo receptor occupancy assayBinding affinity of the [35S]- radiolabeled compound to human Bradykinin receptor B1 over-expressed in transgenic rats was determined by ex vivo receptor occupancy assay
ChEMBL 567 8 3 6 3.5 O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc2ccccc2c1)NCCc1ccc(C2=NCCN2)cc1 10.1016/j.bmcl.2004.09.074
11757682 128818 0 None 2 4 Human 10.7 pKi = 10.7 Binding
Binding affinity of the [35S]- radiolabeled compound to rhesus monkey Bradykinin receptor B1Binding affinity of the [35S]- radiolabeled compound to rhesus monkey Bradykinin receptor B1
ChEMBL 567 8 3 6 3.5 O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc2ccccc2c1)NCCc1ccc(C2=NCCN2)cc1 10.1016/j.bmcl.2004.09.074
CHEMBL359553 128818 0 None 2 4 Human 10.7 pKi = 10.7 Binding
Binding affinity of the [35S]- radiolabeled compound to rhesus monkey Bradykinin receptor B1Binding affinity of the [35S]- radiolabeled compound to rhesus monkey Bradykinin receptor B1
ChEMBL 567 8 3 6 3.5 O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc2ccccc2c1)NCCc1ccc(C2=NCCN2)cc1 10.1016/j.bmcl.2004.09.074
11319515 73503 0 None - 1 Human 10.7 pKi = 10.7 Binding
Binding affinity to human Bradykinin receptor B1 over-expressed in transgenic rats was determined by ex vivo receptor occupancy assayBinding affinity to human Bradykinin receptor B1 over-expressed in transgenic rats was determined by ex vivo receptor occupancy assay
ChEMBL 615 8 2 6 4.5 CN1CCN=C1c1ccc(CCNC(=O)C[C@@H]2C(=O)Nc3ccc(Cl)cc3N2S(=O)(=O)c2ccc3ccccc3c2)cc1 10.1016/j.bmcl.2004.09.074
CHEMBL185693 73503 0 None - 1 Human 10.7 pKi = 10.7 Binding
Binding affinity to human Bradykinin receptor B1 over-expressed in transgenic rats was determined by ex vivo receptor occupancy assayBinding affinity to human Bradykinin receptor B1 over-expressed in transgenic rats was determined by ex vivo receptor occupancy assay
ChEMBL 615 8 2 6 4.5 CN1CCN=C1c1ccc(CCNC(=O)C[C@@H]2C(=O)Nc3ccc(Cl)cc3N2S(=O)(=O)c2ccc3ccccc3c2)cc1 10.1016/j.bmcl.2004.09.074
CHEMBL3085458 217767 6 None 398 2 Human 10.6 pKi = 10.6 Binding
Ability to bind to human cloned B1 receptor in competition binding experiments with [3H][des-Arg10,Leu9]-Kallidin.Ability to bind to human cloned B1 receptor in competition binding experiments with [3H][des-Arg10,Leu9]-Kallidin.
ChEMBL None None None NCCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H]1CSc2ccccc2N(CC(=O)O)C1=O)C1Cc2ccccc2C1 10.1021/jm990961s
CHEMBL3085458 217767 6 None 398 2 Human 10.6 pKi = 10.6 Binding
Binding affinity towards human cloned B1 receptor was determined using [3H][des-Arg10-Leu9]-kallidin as radioligandBinding affinity towards human cloned B1 receptor was determined using [3H][des-Arg10-Leu9]-kallidin as radioligand
ChEMBL None None None NCCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H]1CSc2ccccc2N(CC(=O)O)C1=O)C1Cc2ccccc2C1 10.1021/jm990962k
665 7760 3 None 1023 2 Human 10.5 pKi = 10.5 Binding
Binding affinity to human Bradykinin receptor B1 over-expressed in transgenic rats was determined by ex vivo receptor occupancy assayBinding affinity to human Bradykinin receptor B1 over-expressed in transgenic rats was determined by ex vivo receptor occupancy assay
ChEMBL 585 8 3 6 3.6 O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 10.1016/j.bmcl.2004.09.074
9916412 7760 3 None 1023 2 Human 10.5 pKi = 10.5 Binding
Binding affinity to human Bradykinin receptor B1 over-expressed in transgenic rats was determined by ex vivo receptor occupancy assayBinding affinity to human Bradykinin receptor B1 over-expressed in transgenic rats was determined by ex vivo receptor occupancy assay
ChEMBL 585 8 3 6 3.6 O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 10.1016/j.bmcl.2004.09.074
CHEMBL189123 7760 3 None 1023 2 Human 10.5 pKi = 10.5 Binding
Binding affinity to human Bradykinin receptor B1 over-expressed in transgenic rats was determined by ex vivo receptor occupancy assayBinding affinity to human Bradykinin receptor B1 over-expressed in transgenic rats was determined by ex vivo receptor occupancy assay
ChEMBL 585 8 3 6 3.6 O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 10.1016/j.bmcl.2004.09.074
665 7760 3 None 1023 2 Human 10.5 pKi = 10.5 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 585 8 3 6 3.6 O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 10.1016/j.bmcl.2006.01.112
9916412 7760 3 None 1023 2 Human 10.5 pKi = 10.5 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 585 8 3 6 3.6 O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 10.1016/j.bmcl.2006.01.112
CHEMBL189123 7760 3 None 1023 2 Human 10.5 pKi = 10.5 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 585 8 3 6 3.6 O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 10.1016/j.bmcl.2006.01.112
665 7760 3 None 1023 2 Human 10.5 pKi = 10.5 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 585 8 3 6 3.6 O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 10.1016/j.bmcl.2012.03.065
9916412 7760 3 None 1023 2 Human 10.5 pKi = 10.5 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 585 8 3 6 3.6 O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 10.1016/j.bmcl.2012.03.065
CHEMBL189123 7760 3 None 1023 2 Human 10.5 pKi = 10.5 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 585 8 3 6 3.6 O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 10.1016/j.bmcl.2012.03.065
665 7760 3 None 1023 2 Human 10.5 pKi = 10.5 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration techniqueDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration technique
ChEMBL 585 8 3 6 3.6 O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 10.1016/j.bmcl.2008.07.055
9916412 7760 3 None 1023 2 Human 10.5 pKi = 10.5 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration techniqueDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration technique
ChEMBL 585 8 3 6 3.6 O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 10.1016/j.bmcl.2008.07.055
CHEMBL189123 7760 3 None 1023 2 Human 10.5 pKi = 10.5 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration techniqueDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration technique
ChEMBL 585 8 3 6 3.6 O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 10.1016/j.bmcl.2008.07.055
665 7760 3 None 1023 2 Human 10.5 pKi = 10.5 Binding
Displacement of [3H]Lys0-des-Arg9-BK at human bradykinin B1 receptor expressed in HEK293 cellsDisplacement of [3H]Lys0-des-Arg9-BK at human bradykinin B1 receptor expressed in HEK293 cells
ChEMBL 585 8 3 6 3.6 O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 10.1021/jm1000776
9916412 7760 3 None 1023 2 Human 10.5 pKi = 10.5 Binding
Displacement of [3H]Lys0-des-Arg9-BK at human bradykinin B1 receptor expressed in HEK293 cellsDisplacement of [3H]Lys0-des-Arg9-BK at human bradykinin B1 receptor expressed in HEK293 cells
ChEMBL 585 8 3 6 3.6 O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 10.1021/jm1000776
CHEMBL189123 7760 3 None 1023 2 Human 10.5 pKi = 10.5 Binding
Displacement of [3H]Lys0-des-Arg9-BK at human bradykinin B1 receptor expressed in HEK293 cellsDisplacement of [3H]Lys0-des-Arg9-BK at human bradykinin B1 receptor expressed in HEK293 cells
ChEMBL 585 8 3 6 3.6 O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 10.1021/jm1000776
90662943 113361 0 None 1778 2 Human 10.5 pKi = 10.5 Binding
Ability to bind to human cloned B1 receptor in competition binding experiments with [3H][des-Arg10,Leu9]-Kallidin.Ability to bind to human cloned B1 receptor in competition binding experiments with [3H][des-Arg10,Leu9]-Kallidin.
ChEMBL 1192 30 14 17 -4.3 NCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1CC(O)C[C@H]1C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H]1CSc2ccccc2N(CC(=O)O)C1=O)C1Cc2ccccc2C1 10.1021/jm990961s
CHEMBL3142391 113361 0 None 1778 2 Human 10.5 pKi = 10.5 Binding
Ability to bind to human cloned B1 receptor in competition binding experiments with [3H][des-Arg10,Leu9]-Kallidin.Ability to bind to human cloned B1 receptor in competition binding experiments with [3H][des-Arg10,Leu9]-Kallidin.
ChEMBL 1192 30 14 17 -4.3 NCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1CC(O)C[C@H]1C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H]1CSc2ccccc2N(CC(=O)O)C1=O)C1Cc2ccccc2C1 10.1021/jm990961s
665 7760 3 None 1023 2 Human 10.4 pKi = 10.4 Binding
Binding affinity to human BK1 receptor N298 mutantBinding affinity to human BK1 receptor N298 mutant
ChEMBL 585 8 3 6 3.6 O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 10.1016/j.bmcl.2006.01.112
9916412 7760 3 None 1023 2 Human 10.4 pKi = 10.4 Binding
Binding affinity to human BK1 receptor N298 mutantBinding affinity to human BK1 receptor N298 mutant
ChEMBL 585 8 3 6 3.6 O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 10.1016/j.bmcl.2006.01.112
CHEMBL189123 7760 3 None 1023 2 Human 10.4 pKi = 10.4 Binding
Binding affinity to human BK1 receptor N298 mutantBinding affinity to human BK1 receptor N298 mutant
ChEMBL 585 8 3 6 3.6 O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 10.1016/j.bmcl.2006.01.112
11620871 172814 0 None - 1 Human 10.4 pKi = 10.4 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 543 7 1 7 4.8 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(c4ccncc4)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
CHEMBL425588 172814 0 None - 1 Human 10.4 pKi = 10.4 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 543 7 1 7 4.8 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(c4ccncc4)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
11570120 76831 0 None - 1 Human 10.4 pKi = 10.4 Binding
Displacement of [3H]-DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells membrane after 90 mins by scintillation countingDisplacement of [3H]-DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells membrane after 90 mins by scintillation counting
ChEMBL 536 7 2 5 3.5 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2011.11.112
CHEMBL1939755 76831 0 None - 1 Human 10.4 pKi = 10.4 Binding
Displacement of [3H]-DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells membrane after 90 mins by scintillation countingDisplacement of [3H]-DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells membrane after 90 mins by scintillation counting
ChEMBL 536 7 2 5 3.5 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2011.11.112
665 7760 3 None 1023 2 Human 10.3 pKi = 10.3 Binding
Binding affinity to human BK1 receptor D291 mutantBinding affinity to human BK1 receptor D291 mutant
ChEMBL 585 8 3 6 3.6 O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 10.1016/j.bmcl.2006.01.112
9916412 7760 3 None 1023 2 Human 10.3 pKi = 10.3 Binding
Binding affinity to human BK1 receptor D291 mutantBinding affinity to human BK1 receptor D291 mutant
ChEMBL 585 8 3 6 3.6 O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 10.1016/j.bmcl.2006.01.112
CHEMBL189123 7760 3 None 1023 2 Human 10.3 pKi = 10.3 Binding
Binding affinity to human BK1 receptor D291 mutantBinding affinity to human BK1 receptor D291 mutant
ChEMBL 585 8 3 6 3.6 O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 10.1016/j.bmcl.2006.01.112
11757682 128818 0 None -2 4 Rabbit 10.3 pKi = 10.3 Binding
Binding affinity of the [35S]- radiolabeled compound to rabbit Bradykinin receptor B1Binding affinity of the [35S]- radiolabeled compound to rabbit Bradykinin receptor B1
ChEMBL 567 8 3 6 3.5 O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc2ccccc2c1)NCCc1ccc(C2=NCCN2)cc1 10.1016/j.bmcl.2004.09.074
CHEMBL359553 128818 0 None -2 4 Rabbit 10.3 pKi = 10.3 Binding
Binding affinity of the [35S]- radiolabeled compound to rabbit Bradykinin receptor B1Binding affinity of the [35S]- radiolabeled compound to rabbit Bradykinin receptor B1
ChEMBL 567 8 3 6 3.5 O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc2ccccc2c1)NCCc1ccc(C2=NCCN2)cc1 10.1016/j.bmcl.2004.09.074
11620871 172814 0 None - 1 Human 10.3 pKi = 10.3 Binding
Binding affinity to human BK1 receptor E273 mutantBinding affinity to human BK1 receptor E273 mutant
ChEMBL 543 7 1 7 4.8 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(c4ccncc4)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
CHEMBL425588 172814 0 None - 1 Human 10.3 pKi = 10.3 Binding
Binding affinity to human BK1 receptor E273 mutantBinding affinity to human BK1 receptor E273 mutant
ChEMBL 543 7 1 7 4.8 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(c4ccncc4)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
11365433 73508 0 None - 1 Human 10.2 pKi = 10.2 Binding
Binding affinity to human Bradykinin receptor B1 over-expressed in transgenic rats was determined by ex vivo receptor occupancy assayBinding affinity to human Bradykinin receptor B1 over-expressed in transgenic rats was determined by ex vivo receptor occupancy assay
ChEMBL 599 8 3 5 5.1 O=C(C[C@@H]1C(=O)Nc2ccc(Cl)cc2N1S(=O)(=O)c1ccc2ccccc2c1)NCCc1ccc(-c2ncc[nH]2)cc1 10.1016/j.bmcl.2004.09.074
CHEMBL185727 73508 0 None - 1 Human 10.2 pKi = 10.2 Binding
Binding affinity to human Bradykinin receptor B1 over-expressed in transgenic rats was determined by ex vivo receptor occupancy assayBinding affinity to human Bradykinin receptor B1 over-expressed in transgenic rats was determined by ex vivo receptor occupancy assay
ChEMBL 599 8 3 5 5.1 O=C(C[C@@H]1C(=O)Nc2ccc(Cl)cc2N1S(=O)(=O)c1ccc2ccccc2c1)NCCc1ccc(-c2ncc[nH]2)cc1 10.1016/j.bmcl.2004.09.074
11180561 73525 0 None - 1 Human 10.2 pKi = 10.2 Binding
Binding affinity to human Bradykinin receptor B1 over-expressed in transgenic rats was determined by ex vivo receptor occupancy assayBinding affinity to human Bradykinin receptor B1 over-expressed in transgenic rats was determined by ex vivo receptor occupancy assay
ChEMBL 565 8 3 5 4.5 O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc2ccccc2c1)NCCc1ccc(-c2ncc[nH]2)cc1 10.1016/j.bmcl.2004.09.074
CHEMBL185811 73525 0 None - 1 Human 10.2 pKi = 10.2 Binding
Binding affinity to human Bradykinin receptor B1 over-expressed in transgenic rats was determined by ex vivo receptor occupancy assayBinding affinity to human Bradykinin receptor B1 over-expressed in transgenic rats was determined by ex vivo receptor occupancy assay
ChEMBL 565 8 3 5 4.5 O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc2ccccc2c1)NCCc1ccc(-c2ncc[nH]2)cc1 10.1016/j.bmcl.2004.09.074
11620871 172814 0 None - 1 Human 10.1 pKi = 10.1 Binding
Binding affinity to human BK1 receptor D291 mutantBinding affinity to human BK1 receptor D291 mutant
ChEMBL 543 7 1 7 4.8 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(c4ccncc4)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
CHEMBL425588 172814 0 None - 1 Human 10.1 pKi = 10.1 Binding
Binding affinity to human BK1 receptor D291 mutantBinding affinity to human BK1 receptor D291 mutant
ChEMBL 543 7 1 7 4.8 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(c4ccncc4)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
44587187 195490 0 None - 1 Human 10.0 pKi = 10 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration techniqueDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration technique
ChEMBL 640 7 2 5 6.1 O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2008.07.055
CHEMBL504531 195490 0 None - 1 Human 10.0 pKi = 10 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration techniqueDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration technique
ChEMBL 640 7 2 5 6.1 O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2008.07.055
10288906 143176 0 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 484 7 2 4 4.2 COC(=O)c1c(F)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)CC(F)(F)F)CC2)c(F)c1 10.1021/jm061094b
CHEMBL373530 143176 0 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 484 7 2 4 4.2 COC(=O)c1c(F)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)CC(F)(F)F)CC2)c(F)c1 10.1021/jm061094b
44587186 179497 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration techniqueDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration technique
ChEMBL 642 7 2 6 5.5 O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)N[C@@H]1CCOc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2008.07.055
CHEMBL450541 179497 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration techniqueDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration technique
ChEMBL 642 7 2 6 5.5 O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)N[C@@H]1CCOc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2008.07.055
53248885 68959 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]-DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells membrane after 90 mins by scintillation countingDisplacement of [3H]-DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells membrane after 90 mins by scintillation counting
ChEMBL 538 7 2 5 3.1 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2011.11.112
CHEMBL1777958 68959 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]-DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells membrane after 90 mins by scintillation countingDisplacement of [3H]-DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells membrane after 90 mins by scintillation counting
ChEMBL 538 7 2 5 3.1 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2011.11.112
24970287 195202 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration techniqueDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration technique
ChEMBL 574 7 2 6 4.2 O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccccc1)N[C@@H]1CCOc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2008.07.055
CHEMBL502140 195202 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration techniqueDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration technique
ChEMBL 574 7 2 6 4.2 O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccccc1)N[C@@H]1CCOc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2008.07.055
57397292 76834 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]-DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells membrane after 90 mins by scintillation countingDisplacement of [3H]-DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells membrane after 90 mins by scintillation counting
ChEMBL 522 7 2 5 3.1 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCC4)ccc32)cc1 10.1016/j.bmcl.2011.11.112
CHEMBL1939758 76834 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]-DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells membrane after 90 mins by scintillation countingDisplacement of [3H]-DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells membrane after 90 mins by scintillation counting
ChEMBL 522 7 2 5 3.1 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCC4)ccc32)cc1 10.1016/j.bmcl.2011.11.112
16041612 179747 0 None - 1 Human 9.7 pKi = 9.7 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 499 8 2 7 4.0 O=C(Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccc(F)cn2)cc1)OCC1CCCO1 10.1021/jm800199h
CHEMBL451761 179747 0 None - 1 Human 9.7 pKi = 9.7 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 499 8 2 7 4.0 O=C(Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccc(F)cn2)cc1)OCC1CCCO1 10.1021/jm800199h
44455519 104644 0 None - 1 Human 9.7 pKi = 9.7 Binding
Binding affinity to human bradykinin B1 receptor expressed in rat CNSBinding affinity to human bradykinin B1 receptor expressed in rat CNS
ChEMBL 542 8 2 3 5.8 C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)CC1)c1ccc(-c2cc(Cl)cc(Cl)c2OCC(F)F)cc1F 10.1016/j.bmcl.2007.11.057
CHEMBL272278 104644 0 None - 1 Human 9.7 pKi = 9.7 Binding
Binding affinity to human bradykinin B1 receptor expressed in rat CNSBinding affinity to human bradykinin B1 receptor expressed in rat CNS
ChEMBL 542 8 2 3 5.8 C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)CC1)c1ccc(-c2cc(Cl)cc(Cl)c2OCC(F)F)cc1F 10.1016/j.bmcl.2007.11.057
11387624 166355 0 None - 1 Human 9.7 pKi = 9.7 Binding
Binding affinity to human bradykinin B1 receptor expressed in rat CNSBinding affinity to human bradykinin B1 receptor expressed in rat CNS
ChEMBL 576 9 2 6 5.6 C[C@@H](NC(=O)C1(NC(=O)c2cc(Cl)no2)CC1)c1ncc(-c2cc(Cl)cc(Cl)c2OCC(F)F)cc1F 10.1016/j.bmcl.2007.11.057
CHEMBL410281 166355 0 None - 1 Human 9.7 pKi = 9.7 Binding
Binding affinity to human bradykinin B1 receptor expressed in rat CNSBinding affinity to human bradykinin B1 receptor expressed in rat CNS
ChEMBL 576 9 2 6 5.6 C[C@@H](NC(=O)C1(NC(=O)c2cc(Cl)no2)CC1)c1ncc(-c2cc(Cl)cc(Cl)c2OCC(F)F)cc1F 10.1016/j.bmcl.2007.11.057
11352746 84301 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 510 10 0 7 1.6 CCN1CCC(N2CCN(C(=O)COCCN(C)S(=O)(=O)c3c(C)cc(OC)cc3C)CC2)CC1 10.1021/jm2016057
CHEMBL2087422 84301 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 510 10 0 7 1.6 CCN1CCC(N2CCN(C(=O)COCCN(C)S(=O)(=O)c3c(C)cc(OC)cc3C)CC2)CC1 10.1021/jm2016057
44316161 168295 0 None 1 2 Human 9.7 pKi = 9.7 Binding
Ability to bind to human cloned B1 receptor in competition binding experiments with [3H][des-Arg10,Leu9]-Kallidin.Ability to bind to human cloned B1 receptor in competition binding experiments with [3H][des-Arg10,Leu9]-Kallidin.
ChEMBL 1043 25 12 16 -4.0 NCCCCC(N)C(=O)N[C@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1CC(O)C[C@H]1C(=O)NCC(=O)NC(Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N[C@@H]1CSc2ccccc2N(CC(=O)O)C1=O 10.1021/jm990961s
CHEMBL412824 168295 0 None 1 2 Human 9.7 pKi = 9.7 Binding
Ability to bind to human cloned B1 receptor in competition binding experiments with [3H][des-Arg10,Leu9]-Kallidin.Ability to bind to human cloned B1 receptor in competition binding experiments with [3H][des-Arg10,Leu9]-Kallidin.
ChEMBL 1043 25 12 16 -4.0 NCCCCC(N)C(=O)N[C@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1CC(O)C[C@H]1C(=O)NCC(=O)NC(Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N[C@@H]1CSc2ccccc2N(CC(=O)O)C1=O 10.1021/jm990961s
122227 8160 31 None 6 3 Human 9.7 pKi = 9.7 Binding
Displacement of [3H](Des-Arg10)-Kallidin from bradykinin B1 receptor in human IMR90 cells after 60 minsDisplacement of [3H](Des-Arg10)-Kallidin from bradykinin B1 receptor in human IMR90 cells after 60 mins
ChEMBL None None None None 10.1016/j.bmcl.2013.01.025
3825 8160 31 None 6 3 Human 9.7 pKi = 9.7 Binding
Displacement of [3H](Des-Arg10)-Kallidin from bradykinin B1 receptor in human IMR90 cells after 60 minsDisplacement of [3H](Des-Arg10)-Kallidin from bradykinin B1 receptor in human IMR90 cells after 60 mins
ChEMBL None None None None 10.1016/j.bmcl.2013.01.025
644 8160 31 None 6 3 Human 9.7 pKi = 9.7 Binding
Displacement of [3H](Des-Arg10)-Kallidin from bradykinin B1 receptor in human IMR90 cells after 60 minsDisplacement of [3H](Des-Arg10)-Kallidin from bradykinin B1 receptor in human IMR90 cells after 60 mins
ChEMBL None None None None 10.1016/j.bmcl.2013.01.025
CHEMBL264100 8160 31 None 6 3 Human 9.7 pKi = 9.7 Binding
Displacement of [3H](Des-Arg10)-Kallidin from bradykinin B1 receptor in human IMR90 cells after 60 minsDisplacement of [3H](Des-Arg10)-Kallidin from bradykinin B1 receptor in human IMR90 cells after 60 mins
ChEMBL None None None None 10.1016/j.bmcl.2013.01.025
44587189 179220 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]-DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells membrane after 90 mins by scintillation countingDisplacement of [3H]-DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells membrane after 90 mins by scintillation counting
ChEMBL 588 7 2 6 4.5 Cc1ccc(S(=O)(=O)N2c3ccccc3NC(=O)[C@H]2CC(=O)N[C@@H]2CCOc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2011.11.112
CHEMBL447870 179220 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]-DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells membrane after 90 mins by scintillation countingDisplacement of [3H]-DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells membrane after 90 mins by scintillation counting
ChEMBL 588 7 2 6 4.5 Cc1ccc(S(=O)(=O)N2c3ccccc3NC(=O)[C@H]2CC(=O)N[C@@H]2CCOc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2011.11.112
16108969 89806 0 None 239883 2 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cells
ChEMBL 581 9 2 4 6.4 O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1021/jm061224g
CHEMBL218152 89806 0 None 239883 2 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cells
ChEMBL 581 9 2 4 6.4 O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1021/jm061224g
44587189 179220 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration techniqueDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration technique
ChEMBL 588 7 2 6 4.5 Cc1ccc(S(=O)(=O)N2c3ccccc3NC(=O)[C@H]2CC(=O)N[C@@H]2CCOc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2008.07.055
CHEMBL447870 179220 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration techniqueDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration technique
ChEMBL 588 7 2 6 4.5 Cc1ccc(S(=O)(=O)N2c3ccccc3NC(=O)[C@H]2CC(=O)N[C@@H]2CCOc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2008.07.055
16108969 89806 0 None 239883 2 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells
ChEMBL 581 9 2 4 6.4 O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2008.07.108
CHEMBL218152 89806 0 None 239883 2 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells
ChEMBL 581 9 2 4 6.4 O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2008.07.108
24895452 193078 0 None - 1 Human 9.6 pKi = 9.6 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 520 10 3 5 4.7 O=C(NCCCN1CCCCC1)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1 10.1021/jm800199h
CHEMBL487445 193078 0 None - 1 Human 9.6 pKi = 9.6 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 520 10 3 5 4.7 O=C(NCCCN1CCCCC1)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1 10.1021/jm800199h
24895452 193078 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]Lys0-des-Arg9-BK at human bradykinin B1 receptor expressed in HEK293 cellsDisplacement of [3H]Lys0-des-Arg9-BK at human bradykinin B1 receptor expressed in HEK293 cells
ChEMBL 520 10 3 5 4.7 O=C(NCCCN1CCCCC1)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1 10.1021/jm1000776
CHEMBL487445 193078 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]Lys0-des-Arg9-BK at human bradykinin B1 receptor expressed in HEK293 cellsDisplacement of [3H]Lys0-des-Arg9-BK at human bradykinin B1 receptor expressed in HEK293 cells
ChEMBL 520 10 3 5 4.7 O=C(NCCCN1CCCCC1)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1 10.1021/jm1000776
11848206 23869 51 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]Lys0-des-Arg9-BK at human bradykinin B1 receptor expressed in HEK293 cellsDisplacement of [3H]Lys0-des-Arg9-BK at human bradykinin B1 receptor expressed in HEK293 cells
ChEMBL 500 3 0 4 5.4 O=C(c1cccc(N2Cc3cccc(Cl)c3C2=O)c1)N1CCC2(CC1)CCN(c1ccncc1)CC2 10.1021/jm1000776
CHEMBL1254945 23869 51 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]Lys0-des-Arg9-BK at human bradykinin B1 receptor expressed in HEK293 cellsDisplacement of [3H]Lys0-des-Arg9-BK at human bradykinin B1 receptor expressed in HEK293 cells
ChEMBL 500 3 0 4 5.4 O=C(c1cccc(N2Cc3cccc(Cl)c3C2=O)c1)N1CCC2(CC1)CCN(c1ccncc1)CC2 10.1021/jm1000776
11953367 23843 19 None 19 2 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 502 11 1 7 2.0 COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N(C)Cc2ccc(C3=NCCN3)cc2)c(C)c1 10.1021/jm2016057
CHEMBL1254771 23843 19 None 19 2 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 502 11 1 7 2.0 COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N(C)Cc2ccc(C3=NCCN3)cc2)c(C)c1 10.1021/jm2016057
44455075 102127 0 None - 1 Human 9.5 pKi = 9.5 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 482 5 2 5 4.5 COC(=O)c1c(Cl)cc(Cl)cc1-c1cnc([C@@H](C)NC(=O)[C@@](C)(O)C(F)(F)F)c(F)c1 10.1016/j.bmcl.2007.11.050
CHEMBL256671 102127 0 None - 1 Human 9.5 pKi = 9.5 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 482 5 2 5 4.5 COC(=O)c1c(Cl)cc(Cl)cc1-c1cnc([C@@H](C)NC(=O)[C@@](C)(O)C(F)(F)F)c(F)c1 10.1016/j.bmcl.2007.11.050
11953367 23843 19 None 19 2 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]Lys0-des-Arg9-BK at human bradykinin B1 receptor expressed in HEK293 cellsDisplacement of [3H]Lys0-des-Arg9-BK at human bradykinin B1 receptor expressed in HEK293 cells
ChEMBL 502 11 1 7 2.0 COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N(C)Cc2ccc(C3=NCCN3)cc2)c(C)c1 10.1021/jm1000776
CHEMBL1254771 23843 19 None 19 2 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]Lys0-des-Arg9-BK at human bradykinin B1 receptor expressed in HEK293 cellsDisplacement of [3H]Lys0-des-Arg9-BK at human bradykinin B1 receptor expressed in HEK293 cells
ChEMBL 502 11 1 7 2.0 COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N(C)Cc2ccc(C3=NCCN3)cc2)c(C)c1 10.1021/jm1000776
44580744 194668 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]des-arg10leu9kallidin from human bradykinin B1 receptor expressed in CHO cells by Wallac beta-plate scintillation countingDisplacement of [3H]des-arg10leu9kallidin from human bradykinin B1 receptor expressed in CHO cells by Wallac beta-plate scintillation counting
ChEMBL 480 5 2 8 2.9 C[C@@H](NC(=O)C1(O)CCSC1)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F 10.1016/j.bmcl.2008.07.126
CHEMBL496530 194668 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]des-arg10leu9kallidin from human bradykinin B1 receptor expressed in CHO cells by Wallac beta-plate scintillation countingDisplacement of [3H]des-arg10leu9kallidin from human bradykinin B1 receptor expressed in CHO cells by Wallac beta-plate scintillation counting
ChEMBL 480 5 2 8 2.9 C[C@@H](NC(=O)C1(O)CCSC1)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F 10.1016/j.bmcl.2008.07.126
44430696 94727 0 None - 1 Human 9.4 pKi = 9.4 Binding
Binding affinity at human bradykinin B1 receptorBinding affinity at human bradykinin B1 receptor
ChEMBL 484 6 2 4 6.1 N#CC1(c2ccccc2C(F)(F)F)CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1 10.1016/j.bmcl.2007.03.059
CHEMBL234096 94727 0 None - 1 Human 9.4 pKi = 9.4 Binding
Binding affinity at human bradykinin B1 receptorBinding affinity at human bradykinin B1 receptor
ChEMBL 484 6 2 4 6.1 N#CC1(c2ccccc2C(F)(F)F)CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1 10.1016/j.bmcl.2007.03.059
23628223 94710 0 None - 1 Human 9.4 pKi = 9.4 Binding
Binding affinity to human bradykinin B1 receptor expressed in rat CNSBinding affinity to human bradykinin B1 receptor expressed in rat CNS
ChEMBL 520 6 2 4 5.0 COC(=O)c1c(Cl)cc(Cl)cc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1016/j.bmcl.2007.11.057
CHEMBL233968 94710 0 None - 1 Human 9.4 pKi = 9.4 Binding
Binding affinity to human bradykinin B1 receptor expressed in rat CNSBinding affinity to human bradykinin B1 receptor expressed in rat CNS
ChEMBL 520 6 2 4 5.0 COC(=O)c1c(Cl)cc(Cl)cc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1016/j.bmcl.2007.11.057
44455268 101984 0 None - 1 Human 9.4 pKi = 9.4 Binding
Binding affinity to human bradykinin B1 receptor expressed in rat CNSBinding affinity to human bradykinin B1 receptor expressed in rat CNS
ChEMBL 542 9 2 6 5.0 C[C@@H](NC(=O)C1(NC(=O)c2ccno2)CC1)c1ncc(-c2cc(Cl)cc(Cl)c2OCC(F)F)cc1F 10.1016/j.bmcl.2007.11.057
CHEMBL255997 101984 0 None - 1 Human 9.4 pKi = 9.4 Binding
Binding affinity to human bradykinin B1 receptor expressed in rat CNSBinding affinity to human bradykinin B1 receptor expressed in rat CNS
ChEMBL 542 9 2 6 5.0 C[C@@H](NC(=O)C1(NC(=O)c2ccno2)CC1)c1ncc(-c2cc(Cl)cc(Cl)c2OCC(F)F)cc1F 10.1016/j.bmcl.2007.11.057
44455087 162345 0 None - 1 Human 9.4 pKi = 9.4 Binding
Binding affinity to human bradykinin B1 receptor expressed in rat CNSBinding affinity to human bradykinin B1 receptor expressed in rat CNS
ChEMBL 549 8 2 7 4.7 COC(=O)c1c(Cl)cc(Cl)cc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)c3cc(OC)no3)CC2)c(F)c1 10.1016/j.bmcl.2007.11.057
CHEMBL404370 162345 0 None - 1 Human 9.4 pKi = 9.4 Binding
Binding affinity to human bradykinin B1 receptor expressed in rat CNSBinding affinity to human bradykinin B1 receptor expressed in rat CNS
ChEMBL 549 8 2 7 4.7 COC(=O)c1c(Cl)cc(Cl)cc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)c3cc(OC)no3)CC2)c(F)c1 10.1016/j.bmcl.2007.11.057
16221282 92312 0 None 316 2 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 619 9 2 5 5.9 O=C(C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1)N[C@@H]1CCOc2cc(CN3CCCCC3)ccc21 10.1021/jm070055c
CHEMBL227713 92312 0 None 316 2 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 619 9 2 5 5.9 O=C(C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1)N[C@@H]1CCOc2cc(CN3CCCCC3)ccc21 10.1021/jm070055c
10173772 168650 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 452 7 2 4 3.5 COC(=O)c1c(F)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)F)CC2)c(F)c1 10.1021/jm061094b
CHEMBL414962 168650 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 452 7 2 4 3.5 COC(=O)c1c(F)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)F)CC2)c(F)c1 10.1021/jm061094b
11283865 84313 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 523 10 0 6 3.3 COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCC(C3CCN(C(C)C)CC3)CC2)c(C)c1 10.1021/jm2016057
CHEMBL2087434 84313 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 523 10 0 6 3.3 COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCC(C3CCN(C(C)C)CC3)CC2)c(C)c1 10.1021/jm2016057
11442712 92001 0 None 1 3 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]des-arg10, leu9-kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-arg10, leu9-kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 466 7 2 6 5.4 COC(=O)c1c(F)cccc1-c1ccc([C@@H](C)Nc2nccc(Cl)c2NC(=O)CC#N)cc1 10.1021/jm049394l
CHEMBL225607 92001 0 None 1 3 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]des-arg10, leu9-kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-arg10, leu9-kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 466 7 2 6 5.4 COC(=O)c1c(F)cccc1-c1ccc([C@@H](C)Nc2nccc(Cl)c2NC(=O)CC#N)cc1 10.1021/jm049394l
24884552 191074 1 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]des-arg10leu9kallidin from human bradykinin B1 receptor expressed in CHO cells by Wallac beta-plate scintillation countingDisplacement of [3H]des-arg10leu9kallidin from human bradykinin B1 receptor expressed in CHO cells by Wallac beta-plate scintillation counting
ChEMBL 512 5 2 7 4.0 C[C@@H](NC(=O)C1(O)CCC(F)(F)CC1)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F 10.1016/j.bmcl.2008.07.126
CHEMBL484055 191074 1 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]des-arg10leu9kallidin from human bradykinin B1 receptor expressed in CHO cells by Wallac beta-plate scintillation countingDisplacement of [3H]des-arg10leu9kallidin from human bradykinin B1 receptor expressed in CHO cells by Wallac beta-plate scintillation counting
ChEMBL 512 5 2 7 4.0 C[C@@H](NC(=O)C1(O)CCC(F)(F)CC1)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F 10.1016/j.bmcl.2008.07.126
44455004 104462 0 None - 1 Human 9.4 pKi = 9.4 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 506 5 2 7 3.9 C[C@@H](NC(=O)[C@@](C)(O)C(F)(F)F)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1Cl 10.1016/j.bmcl.2007.11.050
CHEMBL271283 104462 0 None - 1 Human 9.4 pKi = 9.4 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 506 5 2 7 3.9 C[C@@H](NC(=O)[C@@](C)(O)C(F)(F)F)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1Cl 10.1016/j.bmcl.2007.11.050
16102897 94014 17 None 7 3 Human 9.4 pKi = 9.4 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 486 6 2 4 4.3 COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1016/j.bmcl.2007.04.040
CHEMBL232943 94014 17 None 7 3 Human 9.4 pKi = 9.4 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 486 6 2 4 4.3 COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1016/j.bmcl.2007.04.040
44587184 176933 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration techniqueDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration technique
ChEMBL 630 9 3 6 5.3 CC(C)CNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2008.07.055
CHEMBL444431 176933 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration techniqueDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration technique
ChEMBL 630 9 3 6 5.3 CC(C)CNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2008.07.055
16102897 94014 17 None 7 3 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 486 6 2 4 4.3 COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1021/jm061094b
CHEMBL232943 94014 17 None 7 3 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 486 6 2 4 4.3 COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1021/jm061094b
16102897 94014 17 None 7 3 Human 9.4 pKi = 9.4 Binding
Inhibition of human bradykinin B1 receptorInhibition of human bradykinin B1 receptor
ChEMBL 486 6 2 4 4.3 COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1016/j.bmcl.2008.08.014
CHEMBL232943 94014 17 None 7 3 Human 9.4 pKi = 9.4 Binding
Inhibition of human bradykinin B1 receptorInhibition of human bradykinin B1 receptor
ChEMBL 486 6 2 4 4.3 COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1016/j.bmcl.2008.08.014
23628223 94710 0 None - 1 Human 9.3 pKi = 9.3 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 520 6 2 4 5.0 COC(=O)c1c(Cl)cc(Cl)cc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1016/j.bmcl.2007.04.040
CHEMBL233968 94710 0 None - 1 Human 9.3 pKi = 9.3 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 520 6 2 4 5.0 COC(=O)c1c(Cl)cc(Cl)cc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1016/j.bmcl.2007.04.040
57390218 76836 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]-DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells membrane after 90 mins by scintillation countingDisplacement of [3H]-DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells membrane after 90 mins by scintillation counting
ChEMBL 538 8 3 5 3.7 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNCC(C)(C)C)ccc32)cc1 10.1016/j.bmcl.2011.11.112
CHEMBL1939760 76836 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]-DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells membrane after 90 mins by scintillation countingDisplacement of [3H]-DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells membrane after 90 mins by scintillation counting
ChEMBL 538 8 3 5 3.7 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNCC(C)(C)C)ccc32)cc1 10.1016/j.bmcl.2011.11.112
44580743 199424 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]des-arg10leu9kallidin from human bradykinin B1 receptor expressed in CHO cells by Wallac beta-plate scintillation countingDisplacement of [3H]des-arg10leu9kallidin from human bradykinin B1 receptor expressed in CHO cells by Wallac beta-plate scintillation counting
ChEMBL 462 5 2 7 3.4 C[C@@H](NC(=O)C1(O)CCCC1)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F 10.1016/j.bmcl.2008.07.126
CHEMBL521735 199424 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]des-arg10leu9kallidin from human bradykinin B1 receptor expressed in CHO cells by Wallac beta-plate scintillation countingDisplacement of [3H]des-arg10leu9kallidin from human bradykinin B1 receptor expressed in CHO cells by Wallac beta-plate scintillation counting
ChEMBL 462 5 2 7 3.4 C[C@@H](NC(=O)C1(O)CCCC1)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F 10.1016/j.bmcl.2008.07.126
11757682 128818 0 None -28 4 Dog 9.3 pKi = 9.3 Binding
Binding affinity of the [35S]- radiolabeled compound to dog Bradykinin receptor B1Binding affinity of the [35S]- radiolabeled compound to dog Bradykinin receptor B1
ChEMBL 567 8 3 6 3.5 O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc2ccccc2c1)NCCc1ccc(C2=NCCN2)cc1 10.1016/j.bmcl.2004.09.074
CHEMBL359553 128818 0 None -28 4 Dog 9.3 pKi = 9.3 Binding
Binding affinity of the [35S]- radiolabeled compound to dog Bradykinin receptor B1Binding affinity of the [35S]- radiolabeled compound to dog Bradykinin receptor B1
ChEMBL 567 8 3 6 3.5 O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc2ccccc2c1)NCCc1ccc(C2=NCCN2)cc1 10.1016/j.bmcl.2004.09.074
11284564 162369 1 None - 1 Human 9.3 pKi = 9.3 Binding
Binding affinity to human bradykinin B1 receptor expressed in rat CNSBinding affinity to human bradykinin B1 receptor expressed in rat CNS
ChEMBL 572 10 2 7 5.0 COc1cc(C(=O)NC2(C(=O)N[C@H](C)c3ncc(-c4cc(Cl)cc(Cl)c4OCC(F)F)cc3F)CC2)on1 10.1016/j.bmcl.2007.11.057
CHEMBL404484 162369 1 None - 1 Human 9.3 pKi = 9.3 Binding
Binding affinity to human bradykinin B1 receptor expressed in rat CNSBinding affinity to human bradykinin B1 receptor expressed in rat CNS
ChEMBL 572 10 2 7 5.0 COc1cc(C(=O)NC2(C(=O)N[C@H](C)c3ncc(-c4cc(Cl)cc(Cl)c4OCC(F)F)cc3F)CC2)on1 10.1016/j.bmcl.2007.11.057
11363856 91310 0 None 5 3 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]des-arg10, leu9-kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-arg10, leu9-kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 490 7 2 7 5.9 Cc1noc(-c2c(F)cccc2-c2ccc([C@@H](C)Nc3nccc(Cl)c3NC(=O)CC#N)cc2)n1 10.1021/jm049394l
CHEMBL222038 91310 0 None 5 3 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]des-arg10, leu9-kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-arg10, leu9-kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 490 7 2 7 5.9 Cc1noc(-c2c(F)cccc2-c2ccc([C@@H](C)Nc3nccc(Cl)c3NC(=O)CC#N)cc2)n1 10.1021/jm049394l
11225601 148805 0 None 6 3 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]des-arg10, leu9-kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-arg10, leu9-kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 490 7 2 8 4.8 C[C@@H](Nc1nccc(Cl)c1NC(=O)CC#N)c1ccc(-c2cccc(F)c2-c2nnn(C)n2)cc1 10.1021/jm049394l
CHEMBL387638 148805 0 None 6 3 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]des-arg10, leu9-kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-arg10, leu9-kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 490 7 2 8 4.8 C[C@@H](Nc1nccc(Cl)c1NC(=O)CC#N)c1ccc(-c2cccc(F)c2-c2nnn(C)n2)cc1 10.1021/jm049394l
16726096 162047 9 None 2 4 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]des-arg10leu9kallidin from human bradykinin B1 receptor expressed in CHO cells by Wallac beta-plate scintillation countingDisplacement of [3H]des-arg10leu9kallidin from human bradykinin B1 receptor expressed in CHO cells by Wallac beta-plate scintillation counting
ChEMBL 490 5 2 6 4.5 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)[C@@](C)(O)C(F)(F)F)c(F)c2)no1 10.1016/j.bmcl.2008.07.126
CHEMBL402831 162047 9 None 2 4 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]des-arg10leu9kallidin from human bradykinin B1 receptor expressed in CHO cells by Wallac beta-plate scintillation countingDisplacement of [3H]des-arg10leu9kallidin from human bradykinin B1 receptor expressed in CHO cells by Wallac beta-plate scintillation counting
ChEMBL 490 5 2 6 4.5 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)[C@@](C)(O)C(F)(F)F)c(F)c2)no1 10.1016/j.bmcl.2008.07.126
10217706 90000 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 494 6 2 5 4.4 Cc1noc(-c2c(F)cccc2-c2ccc([C@@H](C)NC(=O)C3(NC(=O)C(F)(F)F)CC3)c(F)c2)n1 10.1021/jm061094b
CHEMBL218605 90000 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 494 6 2 5 4.4 Cc1noc(-c2c(F)cccc2-c2ccc([C@@H](C)NC(=O)C3(NC(=O)C(F)(F)F)CC3)c(F)c2)n1 10.1021/jm061094b
16102883 172645 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 470 7 2 4 3.5 COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)C2(NC(=O)C(Cl)Cl)CC2)c(F)c1 10.1021/jm061094b
CHEMBL424919 172645 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 470 7 2 4 3.5 COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)C2(NC(=O)C(Cl)Cl)CC2)c(F)c1 10.1021/jm061094b
57400696 76835 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]-DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells membrane after 90 mins by scintillation countingDisplacement of [3H]-DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells membrane after 90 mins by scintillation counting
ChEMBL 508 8 3 5 2.8 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC4CC4)ccc32)cc1 10.1016/j.bmcl.2011.11.112
CHEMBL1939759 76835 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]-DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells membrane after 90 mins by scintillation countingDisplacement of [3H]-DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells membrane after 90 mins by scintillation counting
ChEMBL 508 8 3 5 2.8 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC4CC4)ccc32)cc1 10.1016/j.bmcl.2011.11.112
10151875 143757 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 470 6 2 4 3.8 COC(=O)c1c(F)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1021/jm061094b
CHEMBL374580 143757 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 470 6 2 4 3.8 COC(=O)c1c(F)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1021/jm061094b
44455035 102499 0 None - 1 Human 9.2 pKi = 9.2 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 490 5 2 7 3.4 C[C@@H](NC(=O)[C@@](C)(O)C(F)(F)F)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F 10.1016/j.bmcl.2007.11.050
CHEMBL258324 102499 0 None - 1 Human 9.2 pKi = 9.2 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 490 5 2 7 3.4 C[C@@H](NC(=O)[C@@](C)(O)C(F)(F)F)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F 10.1016/j.bmcl.2007.11.050
10031511 23718 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]Lys0-des-Arg9-BK at human bradykinin B1 receptor expressed in HEK293 cellsDisplacement of [3H]Lys0-des-Arg9-BK at human bradykinin B1 receptor expressed in HEK293 cells
ChEMBL 601 9 2 6 5.7 CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCN(c4ccncc4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 10.1021/jm1000776
CHEMBL1253497 23718 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]Lys0-des-Arg9-BK at human bradykinin B1 receptor expressed in HEK293 cellsDisplacement of [3H]Lys0-des-Arg9-BK at human bradykinin B1 receptor expressed in HEK293 cells
ChEMBL 601 9 2 6 5.7 CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCN(c4ccncc4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 10.1021/jm1000776
10031511 23718 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Inhibition of human bradykinin B1 receptorInhibition of human bradykinin B1 receptor
ChEMBL 601 9 2 6 5.7 CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCN(c4ccncc4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 10.1021/jm034020y
CHEMBL1253497 23718 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Inhibition of human bradykinin B1 receptorInhibition of human bradykinin B1 receptor
ChEMBL 601 9 2 6 5.7 CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCN(c4ccncc4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 10.1021/jm034020y
9894973 108535 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Inhibition of human bradykinin B1 receptorInhibition of human bradykinin B1 receptor
ChEMBL 601 9 2 6 5.7 CCCN1C(=O)C(NC(=O)Nc2ccc(N3CCN(c4ccncc4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 10.1016/j.bmcl.2008.08.014
CHEMBL299832 108535 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Inhibition of human bradykinin B1 receptorInhibition of human bradykinin B1 receptor
ChEMBL 601 9 2 6 5.7 CCCN1C(=O)C(NC(=O)Nc2ccc(N3CCN(c4ccncc4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 10.1016/j.bmcl.2008.08.014
57383007 133987 0 None - 1 Human 9.2 pKi = 9.2 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 584 8 2 9 3.8 COc1ncc(C(=O)NC2(C(=O)N[C@H](C)c3ccc(-c4cc(Cl)cc(F)c4-c4noc(C)n4)cc3F)COC2)cn1 nan
CHEMBL3657638 133987 0 None - 1 Human 9.2 pKi = 9.2 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 584 8 2 9 3.8 COc1ncc(C(=O)NC2(C(=O)N[C@H](C)c3ccc(-c4cc(Cl)cc(F)c4-c4noc(C)n4)cc3F)COC2)cn1 nan
16747694 94728 0 None - 1 Human 9.2 pKi = 9.2 Binding
Binding affinity at human bradykinin B1 receptorBinding affinity at human bradykinin B1 receptor
ChEMBL 469 6 2 6 5.4 N#CC1(c2ccccc2C(F)(F)F)CCC(CNc2ncccc2NC(=O)c2ccno2)CC1 10.1016/j.bmcl.2007.03.059
CHEMBL234097 94728 0 None - 1 Human 9.2 pKi = 9.2 Binding
Binding affinity at human bradykinin B1 receptorBinding affinity at human bradykinin B1 receptor
ChEMBL 469 6 2 6 5.4 N#CC1(c2ccccc2C(F)(F)F)CCC(CNc2ncccc2NC(=O)c2ccno2)CC1 10.1016/j.bmcl.2007.03.059
24895550 180704 0 None - 1 Human 9.2 pKi = 9.2 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 481 8 2 7 3.8 O=C(Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccn2)cc1)OCC1CCCO1 10.1021/jm800199h
CHEMBL454086 180704 0 None - 1 Human 9.2 pKi = 9.2 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 481 8 2 7 3.8 O=C(Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccn2)cc1)OCC1CCCO1 10.1021/jm800199h
44455090 104241 0 None - 1 Human 9.2 pKi = 9.2 Binding
Binding affinity to human bradykinin B1 receptor expressed in rat CNSBinding affinity to human bradykinin B1 receptor expressed in rat CNS
ChEMBL 506 8 2 6 4.7 CCOc1c(Cl)cc(Cl)cc1-c1cnc([C@@H](C)NC(=O)C2(NC(=O)c3ccno3)CC2)c(F)c1 10.1016/j.bmcl.2007.11.057
CHEMBL270173 104241 0 None - 1 Human 9.2 pKi = 9.2 Binding
Binding affinity to human bradykinin B1 receptor expressed in rat CNSBinding affinity to human bradykinin B1 receptor expressed in rat CNS
ChEMBL 506 8 2 6 4.7 CCOc1c(Cl)cc(Cl)cc1-c1cnc([C@@H](C)NC(=O)C2(NC(=O)c3ccno3)CC2)c(F)c1 10.1016/j.bmcl.2007.11.057
10239095 90690 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 494 6 2 6 3.2 C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)CC1)c1ccc(-c2cccc(F)c2-c2nnn(C)n2)cc1F 10.1021/jm061094b
CHEMBL220657 90690 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 494 6 2 6 3.2 C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)CC1)c1ccc(-c2cccc(F)c2-c2nnn(C)n2)cc1F 10.1021/jm061094b
44455038 102500 0 None - 1 Human 9.2 pKi = 9.2 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 490 5 2 6 4.5 Cc1noc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)[C@@](C)(O)C(F)(F)F)c(F)c2)n1 10.1016/j.bmcl.2007.11.050
CHEMBL258326 102500 0 None - 1 Human 9.2 pKi = 9.2 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 490 5 2 6 4.5 Cc1noc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)[C@@](C)(O)C(F)(F)F)c(F)c2)n1 10.1016/j.bmcl.2007.11.050
16726096 162047 9 None 2 4 Human 9.2 pKi = 9.2 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 490 5 2 6 4.5 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)[C@@](C)(O)C(F)(F)F)c(F)c2)no1 10.1016/j.bmcl.2007.11.050
CHEMBL402831 162047 9 None 2 4 Human 9.2 pKi = 9.2 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 490 5 2 6 4.5 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)[C@@](C)(O)C(F)(F)F)c(F)c2)no1 10.1016/j.bmcl.2007.11.050
16102898 172982 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 510 6 2 6 3.7 C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)CC1)c1ccc(-c2cccc(Cl)c2-c2nnn(C)n2)cc1F 10.1021/jm061094b
CHEMBL426561 172982 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 510 6 2 6 3.7 C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)CC1)c1ccc(-c2cccc(Cl)c2-c2nnn(C)n2)cc1F 10.1021/jm061094b
44580049 191367 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]des-arg10leu9kallidin from human bradykinin B1 receptor expressed in CHO cells by Wallac beta-plate scintillation countingDisplacement of [3H]des-arg10leu9kallidin from human bradykinin B1 receptor expressed in CHO cells by Wallac beta-plate scintillation counting
ChEMBL 476 5 2 8 2.5 C[C@@H](NC(=O)C1(O)CCC(=O)C1)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F 10.1016/j.bmcl.2008.07.126
CHEMBL484881 191367 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]des-arg10leu9kallidin from human bradykinin B1 receptor expressed in CHO cells by Wallac beta-plate scintillation countingDisplacement of [3H]des-arg10leu9kallidin from human bradykinin B1 receptor expressed in CHO cells by Wallac beta-plate scintillation counting
ChEMBL 476 5 2 8 2.5 C[C@@H](NC(=O)C1(O)CCC(=O)C1)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F 10.1016/j.bmcl.2008.07.126
44593650 191370 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]des-arg10leu9kallidin from human bradykinin B1 receptor expressed in CHO cells by Wallac beta-plate scintillation countingDisplacement of [3H]des-arg10leu9kallidin from human bradykinin B1 receptor expressed in CHO cells by Wallac beta-plate scintillation counting
ChEMBL 498 5 2 7 3.6 CC(NC(=O)C1(O)CCC(F)(F)C1)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F 10.1016/j.bmcl.2008.07.126
CHEMBL484882 191370 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]des-arg10leu9kallidin from human bradykinin B1 receptor expressed in CHO cells by Wallac beta-plate scintillation countingDisplacement of [3H]des-arg10leu9kallidin from human bradykinin B1 receptor expressed in CHO cells by Wallac beta-plate scintillation counting
ChEMBL 498 5 2 7 3.6 CC(NC(=O)C1(O)CCC(F)(F)C1)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F 10.1016/j.bmcl.2008.07.126
44432186 93473 0 None - 1 Human 9.2 pKi = 9.2 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 504 6 2 4 4.5 COC(=O)c1c(F)cc(Cl)cc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1016/j.bmcl.2007.04.040
CHEMBL231734 93473 0 None - 1 Human 9.2 pKi = 9.2 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 504 6 2 4 4.5 COC(=O)c1c(F)cc(Cl)cc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1016/j.bmcl.2007.04.040
10196170 143333 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 520 7 2 4 4.4 COC(=O)c1c(F)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)C(F)(F)F)CC2)c(F)c1 10.1021/jm061094b
CHEMBL373803 143333 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 520 7 2 4 4.4 COC(=O)c1c(F)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)C(F)(F)F)CC2)c(F)c1 10.1021/jm061094b
11442712 92001 0 None -1 3 Rabbit 9.2 pKi = 9.2 Binding
Binding affinity to rabbit bradykinin B1 receptorBinding affinity to rabbit bradykinin B1 receptor
ChEMBL 466 7 2 6 5.4 COC(=O)c1c(F)cccc1-c1ccc([C@@H](C)Nc2nccc(Cl)c2NC(=O)CC#N)cc1 10.1021/jm049394l
CHEMBL225607 92001 0 None -1 3 Rabbit 9.2 pKi = 9.2 Binding
Binding affinity to rabbit bradykinin B1 receptorBinding affinity to rabbit bradykinin B1 receptor
ChEMBL 466 7 2 6 5.4 COC(=O)c1c(F)cccc1-c1ccc([C@@H](C)Nc2nccc(Cl)c2NC(=O)CC#N)cc1 10.1021/jm049394l
44580048 190922 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]des-arg10leu9kallidin from human bradykinin B1 receptor expressed in CHO cells by Wallac beta-plate scintillation countingDisplacement of [3H]des-arg10leu9kallidin from human bradykinin B1 receptor expressed in CHO cells by Wallac beta-plate scintillation counting
ChEMBL 512 5 2 9 1.6 C[C@@H](NC(=O)C1(O)CCS(=O)(=O)C1)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F 10.1016/j.bmcl.2008.07.126
CHEMBL482829 190922 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]des-arg10leu9kallidin from human bradykinin B1 receptor expressed in CHO cells by Wallac beta-plate scintillation countingDisplacement of [3H]des-arg10leu9kallidin from human bradykinin B1 receptor expressed in CHO cells by Wallac beta-plate scintillation counting
ChEMBL 512 5 2 9 1.6 C[C@@H](NC(=O)C1(O)CCS(=O)(=O)C1)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F 10.1016/j.bmcl.2008.07.126
16041612 179747 0 None - 1 Human 9.2 pKi = 9.2 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 499 8 2 7 4.0 O=C(Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccc(F)cn2)cc1)OCC1CCCO1 10.1021/jm800199h
CHEMBL451761 179747 0 None - 1 Human 9.2 pKi = 9.2 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 499 8 2 7 4.0 O=C(Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccc(F)cn2)cc1)OCC1CCCO1 10.1021/jm800199h
24893993 180703 5 None - 1 Human 9.2 pKi = 9.2 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 480 8 2 6 4.4 O=C(Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1)OCC1CCCO1 10.1021/jm800199h
CHEMBL454085 180703 5 None - 1 Human 9.2 pKi = 9.2 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 480 8 2 6 4.4 O=C(Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1)OCC1CCCO1 10.1021/jm800199h
44587183 180005 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration techniqueDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration technique
ChEMBL 616 8 3 6 5.0 CC(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2008.07.055
CHEMBL452331 180005 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration techniqueDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration technique
ChEMBL 616 8 3 6 5.0 CC(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2008.07.055
16108961 7710 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 583 9 2 5 5.9 O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 10.1021/jm070055c
664 7710 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 583 9 2 5 5.9 O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 10.1021/jm070055c
CHEMBL415848 7710 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 583 9 2 5 5.9 O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 10.1021/jm070055c
11387915 21994 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptorDisplacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptor
ChEMBL 611 10 2 4 6.4 C=C(CN1CCCC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2010.06.010
CHEMBL1210744 21994 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptorDisplacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptor
ChEMBL 611 10 2 4 6.4 C=C(CN1CCCC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2010.06.010
24893993 180703 5 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]Lys0-des-Arg9-BK at human bradykinin B1 receptor expressed in HEK293 cellsDisplacement of [3H]Lys0-des-Arg9-BK at human bradykinin B1 receptor expressed in HEK293 cells
ChEMBL 480 8 2 6 4.4 O=C(Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1)OCC1CCCO1 10.1021/jm1000776
CHEMBL454085 180703 5 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]Lys0-des-Arg9-BK at human bradykinin B1 receptor expressed in HEK293 cellsDisplacement of [3H]Lys0-des-Arg9-BK at human bradykinin B1 receptor expressed in HEK293 cells
ChEMBL 480 8 2 6 4.4 O=C(Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1)OCC1CCCO1 10.1021/jm1000776
11488817 84312 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 495 9 0 6 2.5 COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCC(C3CCN(C)CC3)CC2)c(C)c1 10.1021/jm2016057
CHEMBL2087433 84312 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 495 9 0 6 2.5 COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCC(C3CCN(C)CC3)CC2)c(C)c1 10.1021/jm2016057
11386138 91216 0 None 1 3 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]des-arg10, leu9-kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-arg10, leu9-kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 482 7 2 6 5.9 COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)Nc2nccc(Cl)c2NC(=O)CC#N)cc1 10.1021/jm049394l
CHEMBL221998 91216 0 None 1 3 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]des-arg10, leu9-kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-arg10, leu9-kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 482 7 2 6 5.9 COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)Nc2nccc(Cl)c2NC(=O)CC#N)cc1 10.1021/jm049394l
11477390 91936 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]des-arg10, leu9-kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-arg10, leu9-kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 490 7 2 7 5.9 Cc1nc(-c2c(F)cccc2-c2ccc([C@@H](C)Nc3nccc(Cl)c3NC(=O)CC#N)cc2)no1 10.1021/jm049394l
CHEMBL225218 91936 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]des-arg10, leu9-kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-arg10, leu9-kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 490 7 2 7 5.9 Cc1nc(-c2c(F)cccc2-c2ccc([C@@H](C)Nc3nccc(Cl)c3NC(=O)CC#N)cc2)no1 10.1021/jm049394l
44411294 84108 0 None - 1 Human 9.2 pKi = 9.2 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 450 7 2 6 4.6 COC(=O)c1c(F)cccc1-c1ccc(CNc2nccc(C)c2NC(=O)CC#N)c(F)c1 10.1016/j.bmcl.2006.01.112
CHEMBL208371 84108 0 None - 1 Human 9.2 pKi = 9.2 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 450 7 2 6 4.6 COC(=O)c1c(F)cccc1-c1ccc(CNc2nccc(C)c2NC(=O)CC#N)c(F)c1 10.1016/j.bmcl.2006.01.112
16726109 153672 0 None - 1 Human 9.1 pKi = 9.1 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 487 6 2 5 3.7 COC(=O)c1c(Cl)cccc1-c1cnc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1016/j.bmcl.2007.04.040
CHEMBL392551 153672 0 None - 1 Human 9.1 pKi = 9.1 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 487 6 2 5 3.7 COC(=O)c1c(Cl)cccc1-c1cnc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1016/j.bmcl.2007.04.040
16108961 7710 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cells
ChEMBL 583 9 2 5 5.9 O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 10.1021/jm061224g
664 7710 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cells
ChEMBL 583 9 2 5 5.9 O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 10.1021/jm061224g
CHEMBL415848 7710 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cells
ChEMBL 583 9 2 5 5.9 O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 10.1021/jm061224g
44455073 102361 0 None - 1 Human 9.1 pKi = 9.1 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 506 5 2 6 5.0 Cc1noc(-c2c(Cl)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)[C@@](C)(O)C(F)(F)F)c(F)c2)n1 10.1016/j.bmcl.2007.11.050
CHEMBL257729 102361 0 None - 1 Human 9.1 pKi = 9.1 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 506 5 2 6 5.0 Cc1noc(-c2c(Cl)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)[C@@](C)(O)C(F)(F)F)c(F)c2)n1 10.1016/j.bmcl.2007.11.050
57382836 133969 0 None - 1 Human 9.1 pKi = 9.1 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 501 7 2 7 3.3 COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)c3ccno3)COC2)c(F)c1 nan
CHEMBL3657620 133969 0 None - 1 Human 9.1 pKi = 9.1 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 501 7 2 7 3.3 COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)c3ccno3)COC2)c(F)c1 nan
68869647 84302 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 522 10 0 7 1.7 COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCN(C3CCN(C4CC4)CC3)CC2)c(C)c1 10.1021/jm2016057
CHEMBL2087423 84302 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 522 10 0 7 1.7 COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCN(C3CCN(C4CC4)CC3)CC2)c(C)c1 10.1021/jm2016057
11167607 144123 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]des-arg10, leu9-kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-arg10, leu9-kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 482 7 2 6 5.9 COC(=O)c1ccc(Cl)cc1-c1ccc([C@@H](C)Nc2nccc(Cl)c2NC(=O)CC#N)cc1 10.1021/jm049394l
CHEMBL375288 144123 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]des-arg10, leu9-kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-arg10, leu9-kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 482 7 2 6 5.9 COC(=O)c1ccc(Cl)cc1-c1ccc([C@@H](C)Nc2nccc(Cl)c2NC(=O)CC#N)cc1 10.1021/jm049394l
44580742 194667 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]des-arg10leu9kallidin from human bradykinin B1 receptor expressed in CHO cells by Wallac beta-plate scintillation countingDisplacement of [3H]des-arg10leu9kallidin from human bradykinin B1 receptor expressed in CHO cells by Wallac beta-plate scintillation counting
ChEMBL 506 6 3 7 3.7 C[C@@H](NC(=O)[C@@](C)(O)C(F)(F)F)c1ncc(-c2cc(Cl)cc(F)c2-c2noc(CO)n2)cc1F 10.1016/j.bmcl.2008.07.126
CHEMBL496529 194667 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]des-arg10leu9kallidin from human bradykinin B1 receptor expressed in CHO cells by Wallac beta-plate scintillation countingDisplacement of [3H]des-arg10leu9kallidin from human bradykinin B1 receptor expressed in CHO cells by Wallac beta-plate scintillation counting
ChEMBL 506 6 3 7 3.7 C[C@@H](NC(=O)[C@@](C)(O)C(F)(F)F)c1ncc(-c2cc(Cl)cc(F)c2-c2noc(CO)n2)cc1F 10.1016/j.bmcl.2008.07.126
44418930 90091 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 470 7 2 4 3.6 COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)C2(NC(=O)CC(F)(F)F)CC2)c(F)c1 10.1021/jm061094b
CHEMBL219083 90091 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 470 7 2 4 3.6 COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)C2(NC(=O)CC(F)(F)F)CC2)c(F)c1 10.1021/jm061094b
16102896 90313 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 486 7 2 4 4.1 COC(=O)c1c(F)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)Cl)CC2)c(F)c1 10.1021/jm061094b
CHEMBL220371 90313 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 486 7 2 4 4.1 COC(=O)c1c(F)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)Cl)CC2)c(F)c1 10.1021/jm061094b
11281533 71851 0 None - 1 Human 9.1 pKi = 9.1 Binding
Binding affinity against Human bradykinin receptor B1Binding affinity against Human bradykinin receptor B1
ChEMBL 418 7 2 6 4.1 COC(=O)C1CC=CCC1c1ccc(CNc2nccc(C)c2NC(=O)CC#N)cc1 10.1016/j.bmcl.2005.05.133
CHEMBL182378 71851 0 None - 1 Human 9.1 pKi = 9.1 Binding
Binding affinity against Human bradykinin receptor B1Binding affinity against Human bradykinin receptor B1
ChEMBL 418 7 2 6 4.1 COC(=O)C1CC=CCC1c1ccc(CNc2nccc(C)c2NC(=O)CC#N)cc1 10.1016/j.bmcl.2005.05.133
11620871 172814 0 None - 1 Human 9.1 pKi = 9.1 Binding
Binding affinity to human BK1 receptor N298 mutantBinding affinity to human BK1 receptor N298 mutant
ChEMBL 543 7 1 7 4.8 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(c4ccncc4)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
CHEMBL425588 172814 0 None - 1 Human 9.1 pKi = 9.1 Binding
Binding affinity to human BK1 receptor N298 mutantBinding affinity to human BK1 receptor N298 mutant
ChEMBL 543 7 1 7 4.8 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(c4ccncc4)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
44411452 83693 0 None - 1 Human 9.1 pKi = 9.1 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 520 8 1 6 4.6 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(CC4CC4)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
CHEMBL207022 83693 0 None - 1 Human 9.1 pKi = 9.1 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 520 8 1 6 4.6 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(CC4CC4)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
665 7760 3 None 1023 2 Human 9.1 pKi = 9.1 Binding
Binding affinity to human BK1 receptor Q295 mutantBinding affinity to human BK1 receptor Q295 mutant
ChEMBL 585 8 3 6 3.6 O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 10.1016/j.bmcl.2006.01.112
9916412 7760 3 None 1023 2 Human 9.1 pKi = 9.1 Binding
Binding affinity to human BK1 receptor Q295 mutantBinding affinity to human BK1 receptor Q295 mutant
ChEMBL 585 8 3 6 3.6 O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 10.1016/j.bmcl.2006.01.112
CHEMBL189123 7760 3 None 1023 2 Human 9.1 pKi = 9.1 Binding
Binding affinity to human BK1 receptor Q295 mutantBinding affinity to human BK1 receptor Q295 mutant
ChEMBL 585 8 3 6 3.6 O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 10.1016/j.bmcl.2006.01.112
CHEMBL2369827 216473 0 None - 1 Human 9.1 pKi = 9.1 Binding
Ability to bind to human cloned B1 receptor in competition binding experiments with [3H][des-Arg10,Leu9]-Kallidin.Ability to bind to human cloned B1 receptor in competition binding experiments with [3H][des-Arg10,Leu9]-Kallidin.
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCCN)C(=O)O 10.1021/jm990961s
44455574 162412 0 None - 1 Human 9.1 pKi = 9.1 Binding
Binding affinity to human bradykinin B1 receptor expressed in rat CNSBinding affinity to human bradykinin B1 receptor expressed in rat CNS
ChEMBL 472 7 2 3 4.9 CCOc1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1016/j.bmcl.2007.11.057
CHEMBL404683 162412 0 None - 1 Human 9.1 pKi = 9.1 Binding
Binding affinity to human bradykinin B1 receptor expressed in rat CNSBinding affinity to human bradykinin B1 receptor expressed in rat CNS
ChEMBL 472 7 2 3 4.9 CCOc1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1016/j.bmcl.2007.11.057
44455875 162416 0 None - 1 Human 9.1 pKi = 9.1 Binding
Binding affinity to human bradykinin B1 receptor expressed in rat CNSBinding affinity to human bradykinin B1 receptor expressed in rat CNS
ChEMBL 556 9 2 3 5.9 C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)CC1)c1ccc(-c2cc(Cl)cc(Cl)c2OC(CF)CF)cc1F 10.1016/j.bmcl.2007.11.057
CHEMBL404705 162416 0 None - 1 Human 9.1 pKi = 9.1 Binding
Binding affinity to human bradykinin B1 receptor expressed in rat CNSBinding affinity to human bradykinin B1 receptor expressed in rat CNS
ChEMBL 556 9 2 3 5.9 C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)CC1)c1ccc(-c2cc(Cl)cc(Cl)c2OC(CF)CF)cc1F 10.1016/j.bmcl.2007.11.057
10031511 23718 0 None -1 2 Rat 9.0 pKi = 9.0 Binding
Binding affinity to rat bradykinin B1 receptorBinding affinity to rat bradykinin B1 receptor
ChEMBL 601 9 2 6 5.7 CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCN(c4ccncc4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 10.1021/jm1000776
CHEMBL1253497 23718 0 None -1 2 Rat 9.0 pKi = 9.0 Binding
Binding affinity to rat bradykinin B1 receptorBinding affinity to rat bradykinin B1 receptor
ChEMBL 601 9 2 6 5.7 CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCN(c4ccncc4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 10.1021/jm1000776
10031511 23718 0 None -1 2 Rat 9.0 pKi = 9.0 Binding
Compound was tested for inhibition against rat Bradykinin receptor B1Compound was tested for inhibition against rat Bradykinin receptor B1
ChEMBL 601 9 2 6 5.7 CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCN(c4ccncc4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 10.1021/jm034020y
CHEMBL1253497 23718 0 None -1 2 Rat 9.0 pKi = 9.0 Binding
Compound was tested for inhibition against rat Bradykinin receptor B1Compound was tested for inhibition against rat Bradykinin receptor B1
ChEMBL 601 9 2 6 5.7 CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCN(c4ccncc4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 10.1021/jm034020y
16102918 91048 0 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 416 6 2 4 3.3 COC(=O)c1c(F)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(C)=O)CC2)c(F)c1 10.1021/jm061094b
CHEMBL221288 91048 0 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 416 6 2 4 3.3 COC(=O)c1c(F)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(C)=O)CC2)c(F)c1 10.1021/jm061094b
44580209 191049 0 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]des-arg10leu9kallidin from human bradykinin B1 receptor expressed in CHO cells by Wallac beta-plate scintillation countingDisplacement of [3H]des-arg10leu9kallidin from human bradykinin B1 receptor expressed in CHO cells by Wallac beta-plate scintillation counting
ChEMBL 478 5 2 8 2.6 C[C@@H](NC(=O)C1(O)CCOCC1)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F 10.1016/j.bmcl.2008.07.126
CHEMBL483858 191049 0 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]des-arg10leu9kallidin from human bradykinin B1 receptor expressed in CHO cells by Wallac beta-plate scintillation countingDisplacement of [3H]des-arg10leu9kallidin from human bradykinin B1 receptor expressed in CHO cells by Wallac beta-plate scintillation counting
ChEMBL 478 5 2 8 2.6 C[C@@H](NC(=O)C1(O)CCOCC1)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F 10.1016/j.bmcl.2008.07.126
57382837 133970 0 None - 1 Human 9.0 pKi = 9 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 515 7 2 7 3.6 COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)c3cc(C)no3)COC2)c(F)c1 nan
CHEMBL3657621 133970 0 None - 1 Human 9.0 pKi = 9 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 515 7 2 7 3.6 COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)c3cc(C)no3)COC2)c(F)c1 nan
57382923 133979 0 None - 1 Human 9.0 pKi = 9 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 557 7 2 9 3.1 Cc1cc(C(=O)NC2(C(=O)N[C@H](C)c3ccc(-c4cc(Cl)cc(F)c4-c4nnn(C)n4)cc3F)COC2)on1 nan
CHEMBL3657630 133979 0 None - 1 Human 9.0 pKi = 9 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 557 7 2 9 3.1 Cc1cc(C(=O)NC2(C(=O)N[C@H](C)c3ccc(-c4cc(Cl)cc(F)c4-c4nnn(C)n4)cc3F)COC2)on1 nan
57382925 133981 0 None - 1 Human 9.0 pKi = 9 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 555 7 2 9 3.2 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)C3(NC(=O)c4ccnnc4)COC3)c(F)c2)no1 nan
CHEMBL3657632 133981 0 None - 1 Human 9.0 pKi = 9 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 555 7 2 9 3.2 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)C3(NC(=O)c4ccnnc4)COC3)c(F)c2)no1 nan
11281533 71851 0 None - 1 Human 9.0 pKi = 9 Binding
Binding affinity against Human bradykinin receptor B1Binding affinity against Human bradykinin receptor B1
ChEMBL 418 7 2 6 4.1 COC(=O)C1CC=CCC1c1ccc(CNc2nccc(C)c2NC(=O)CC#N)cc1 10.1016/j.bmcl.2005.05.133
CHEMBL182378 71851 0 None - 1 Human 9.0 pKi = 9 Binding
Binding affinity against Human bradykinin receptor B1Binding affinity against Human bradykinin receptor B1
ChEMBL 418 7 2 6 4.1 COC(=O)C1CC=CCC1c1ccc(CNc2nccc(C)c2NC(=O)CC#N)cc1 10.1016/j.bmcl.2005.05.133
11320189 72259 1 None - 1 Human 9.0 pKi = 9 Binding
Binding affinity for Bradykinin receptor B1 expressed in HEK293 cellsBinding affinity for Bradykinin receptor B1 expressed in HEK293 cells
ChEMBL 746 17 1 8 4.5 CN(C)CCCN(CCCN(C)C)C(=O)C1CCN(S(=O)(=O)c2ccc(NCC(c3ccccc3)c3ccccc3)c(C(=O)N3CCOCC3)c2)CC1 10.1021/jm049747g
CHEMBL183048 72259 1 None - 1 Human 9.0 pKi = 9 Binding
Binding affinity for Bradykinin receptor B1 expressed in HEK293 cellsBinding affinity for Bradykinin receptor B1 expressed in HEK293 cells
ChEMBL 746 17 1 8 4.5 CN(C)CCCN(CCCN(C)C)C(=O)C1CCN(S(=O)(=O)c2ccc(NCC(c3ccccc3)c3ccccc3)c(C(=O)N3CCOCC3)c2)CC1 10.1021/jm049747g
70685471 80626 0 None - 1 Human 9.0 pKi = 9 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 576 8 2 5 5.1 O=C(CC1c2ccccc2CCN1S(=O)(=O)c1ccc(Cl)c(Cl)c1)N[C@H]1CC[C@H](CCC2=NCCN2)CC1 10.1016/j.bmcl.2012.03.065
CHEMBL2018866 80626 0 None - 1 Human 9.0 pKi = 9 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 576 8 2 5 5.1 O=C(CC1c2ccccc2CCN1S(=O)(=O)c1ccc(Cl)c(Cl)c1)N[C@H]1CC[C@H](CCC2=NCCN2)CC1 10.1016/j.bmcl.2012.03.065
44593650 191370 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]des-arg10leu9kallidin from human bradykinin B1 receptor expressed in CHO cells by Wallac beta-plate scintillation countingDisplacement of [3H]des-arg10leu9kallidin from human bradykinin B1 receptor expressed in CHO cells by Wallac beta-plate scintillation counting
ChEMBL 498 5 2 7 3.6 CC(NC(=O)C1(O)CCC(F)(F)C1)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F 10.1016/j.bmcl.2008.07.126
CHEMBL484882 191370 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]des-arg10leu9kallidin from human bradykinin B1 receptor expressed in CHO cells by Wallac beta-plate scintillation countingDisplacement of [3H]des-arg10leu9kallidin from human bradykinin B1 receptor expressed in CHO cells by Wallac beta-plate scintillation counting
ChEMBL 498 5 2 7 3.6 CC(NC(=O)C1(O)CCC(F)(F)C1)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F 10.1016/j.bmcl.2008.07.126
11786597 74250 0 None - 1 Human 9.0 pKi = 9.0 Binding
Binding affinity to human Bradykinin receptor B1 over-expressed in transgenic rats was determined by ex vivo receptor occupancy assayBinding affinity to human Bradykinin receptor B1 over-expressed in transgenic rats was determined by ex vivo receptor occupancy assay
ChEMBL 583 8 2 6 4.4 O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)NCCc1ccc(-n2ccnc2)cc1 10.1016/j.bmcl.2004.09.074
CHEMBL189245 74250 0 None - 1 Human 9.0 pKi = 9.0 Binding
Binding affinity to human Bradykinin receptor B1 over-expressed in transgenic rats was determined by ex vivo receptor occupancy assayBinding affinity to human Bradykinin receptor B1 over-expressed in transgenic rats was determined by ex vivo receptor occupancy assay
ChEMBL 583 8 2 6 4.4 O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)NCCc1ccc(-n2ccnc2)cc1 10.1016/j.bmcl.2004.09.074
57382750 133962 0 None - 1 Human 9.0 pKi = 9.0 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 555 7 2 9 3.2 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)C3(NC(=O)c4cncnc4)COC3)c(F)c2)no1 nan
CHEMBL3657613 133962 0 None - 1 Human 9.0 pKi = 9.0 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 555 7 2 9 3.2 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)C3(NC(=O)c4cncnc4)COC3)c(F)c2)no1 nan
57382839 133972 0 None - 1 Human 9.0 pKi = 9.0 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 585 8 2 10 3.2 COc1ncc(C(=O)NC2(C(=O)N[C@H](C)c3ncc(-c4cc(Cl)cc(F)c4-c4noc(C)n4)cc3F)COC2)cn1 nan
CHEMBL3657623 133972 0 None - 1 Human 9.0 pKi = 9.0 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 585 8 2 10 3.2 COc1ncc(C(=O)NC2(C(=O)N[C@H](C)c3ncc(-c4cc(Cl)cc(F)c4-c4noc(C)n4)cc3F)COC2)cn1 nan
57383057 133996 0 None - 1 Human 9.0 pKi = 9.0 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 599 10 2 8 4.0 COc1ncc(C(=O)NC2(C(=O)N[C@H](C)c3ncc(-c4cc(Cl)cc(Cl)c4OCC(F)F)cc3F)COC2)cn1 nan
CHEMBL3657647 133996 0 None - 1 Human 9.0 pKi = 9.0 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 599 10 2 8 4.0 COc1ncc(C(=O)NC2(C(=O)N[C@H](C)c3ncc(-c4cc(Cl)cc(Cl)c4OCC(F)F)cc3F)COC2)cn1 nan
57383099 134000 0 None - 1 Human 9.0 pKi = 9.0 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 584 8 2 10 2.7 COc1ncc(C(=O)NC2(C(=O)N[C@H](C)c3ccc(-c4cc(Cl)cc(F)c4-c4nnn(C)n4)cc3F)COC2)cn1 nan
CHEMBL3657651 134000 0 None - 1 Human 9.0 pKi = 9.0 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 584 8 2 10 2.7 COc1ncc(C(=O)NC2(C(=O)N[C@H](C)c3ccc(-c4cc(Cl)cc(F)c4-c4nnn(C)n4)cc3F)COC2)cn1 nan
44432215 93737 0 None - 1 Human 9.0 pKi = 9.0 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 528 6 2 6 3.9 C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)CC1)c1ccc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F 10.1016/j.bmcl.2007.04.040
CHEMBL232354 93737 0 None - 1 Human 9.0 pKi = 9.0 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 528 6 2 6 3.9 C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)CC1)c1ccc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F 10.1016/j.bmcl.2007.04.040
11444668 162323 0 None - 1 Human 9.0 pKi = 9.0 Binding
Binding affinity to human bradykinin B1 receptor expressed in rat CNSBinding affinity to human bradykinin B1 receptor expressed in rat CNS
ChEMBL 586 11 2 7 5.4 CCOc1cc(C(=O)NC2(C(=O)N[C@H](C)c3ncc(-c4cc(Cl)cc(Cl)c4OCC(F)F)cc3F)CC2)on1 10.1016/j.bmcl.2007.11.057
CHEMBL404280 162323 0 None - 1 Human 9.0 pKi = 9.0 Binding
Binding affinity to human bradykinin B1 receptor expressed in rat CNSBinding affinity to human bradykinin B1 receptor expressed in rat CNS
ChEMBL 586 11 2 7 5.4 CCOc1cc(C(=O)NC2(C(=O)N[C@H](C)c3ncc(-c4cc(Cl)cc(Cl)c4OCC(F)F)cc3F)CC2)on1 10.1016/j.bmcl.2007.11.057
11386138 91216 0 None -1 3 Rabbit 9.0 pKi = 9.0 Binding
Binding affinity to rabbit bradykinin B1 receptorBinding affinity to rabbit bradykinin B1 receptor
ChEMBL 482 7 2 6 5.9 COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)Nc2nccc(Cl)c2NC(=O)CC#N)cc1 10.1021/jm049394l
CHEMBL221998 91216 0 None -1 3 Rabbit 9.0 pKi = 9.0 Binding
Binding affinity to rabbit bradykinin B1 receptorBinding affinity to rabbit bradykinin B1 receptor
ChEMBL 482 7 2 6 5.9 COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)Nc2nccc(Cl)c2NC(=O)CC#N)cc1 10.1021/jm049394l
44587185 195717 0 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration techniqueDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration technique
ChEMBL 630 7 3 6 5.4 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2008.07.055
CHEMBL508043 195717 0 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration techniqueDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration technique
ChEMBL 630 7 3 6 5.4 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2008.07.055
11306090 91922 0 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]des-arg10, leu9-kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-arg10, leu9-kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 476 6 2 4 6.6 C[C@@H](Nc1nccc(Cl)c1NC(=O)CC#N)c1ccc(-c2cccc(F)c2C(F)(F)F)cc1 10.1021/jm049394l
CHEMBL225006 91922 0 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]des-arg10, leu9-kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-arg10, leu9-kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 476 6 2 4 6.6 C[C@@H](Nc1nccc(Cl)c1NC(=O)CC#N)c1ccc(-c2cccc(F)c2C(F)(F)F)cc1 10.1021/jm049394l
57382924 133980 0 None - 1 Human 8.9 pKi = 8.9 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 557 7 2 8 4.3 Cc1cc(C(=O)NC2(C(=O)N[C@H](C)c3ccc(-c4cc(Cl)cc(F)c4-c4noc(C)n4)cc3F)COC2)on1 nan
CHEMBL3657631 133980 0 None - 1 Human 8.9 pKi = 8.9 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 557 7 2 8 4.3 Cc1cc(C(=O)NC2(C(=O)N[C@H](C)c3ccc(-c4cc(Cl)cc(F)c4-c4noc(C)n4)cc3F)COC2)on1 nan
57383053 133992 0 None - 1 Human 8.9 pKi = 8.9 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 585 8 2 11 2.0 COc1ncc(C(=O)NC2(C(=O)N[C@H](C)c3ncc(-c4cc(Cl)cc(F)c4-c4nnn(C)n4)cc3F)COC2)cn1 nan
CHEMBL3657643 133992 0 None - 1 Human 8.9 pKi = 8.9 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 585 8 2 11 2.0 COc1ncc(C(=O)NC2(C(=O)N[C@H](C)c3ncc(-c4cc(Cl)cc(F)c4-c4nnn(C)n4)cc3F)COC2)cn1 nan
44432221 94015 0 None - 1 Human 8.9 pKi = 8.9 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 501 7 2 5 4.1 CCOC(=O)c1c(Cl)cccc1-c1cnc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1016/j.bmcl.2007.04.040
CHEMBL232945 94015 0 None - 1 Human 8.9 pKi = 8.9 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 501 7 2 5 4.1 CCOC(=O)c1c(Cl)cccc1-c1cnc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1016/j.bmcl.2007.04.040
16202227 80631 0 None - 1 Human 8.9 pKi = 8.9 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 636 8 2 5 6.1 O=C(CC1c2cc(F)ccc2-c2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)NCCc1ccc(C2=NCCN2)cc1 10.1016/j.bmcl.2012.03.065
CHEMBL2018871 80631 0 None - 1 Human 8.9 pKi = 8.9 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 636 8 2 5 6.1 O=C(CC1c2cc(F)ccc2-c2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)NCCc1ccc(C2=NCCN2)cc1 10.1016/j.bmcl.2012.03.065
24895253 193501 0 None - 1 Human 8.9 pKi = 8.9 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 538 10 3 5 4.7 O=C(NCCCN1CCCC(F)C1)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1 10.1021/jm800199h
CHEMBL488662 193501 0 None - 1 Human 8.9 pKi = 8.9 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 538 10 3 5 4.7 O=C(NCCCN1CCCC(F)C1)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1 10.1021/jm800199h
44455364 161821 0 None - 1 Human 8.9 pKi = 8.9 Binding
Binding affinity to human bradykinin B1 receptor expressed in rat CNSBinding affinity to human bradykinin B1 receptor expressed in rat CNS
ChEMBL 542 9 2 6 5.0 C[C@@H](NC(=O)C1(NC(=O)c2ccon2)CC1)c1ncc(-c2cc(Cl)cc(Cl)c2OCC(F)F)cc1F 10.1016/j.bmcl.2007.11.057
CHEMBL401619 161821 0 None - 1 Human 8.9 pKi = 8.9 Binding
Binding affinity to human bradykinin B1 receptor expressed in rat CNSBinding affinity to human bradykinin B1 receptor expressed in rat CNS
ChEMBL 542 9 2 6 5.0 C[C@@H](NC(=O)C1(NC(=O)c2ccon2)CC1)c1ncc(-c2cc(Cl)cc(Cl)c2OCC(F)F)cc1F 10.1016/j.bmcl.2007.11.057
44587181 195456 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration techniqueDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration technique
ChEMBL 588 7 3 6 4.3 CNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2008.07.055
CHEMBL503847 195456 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration techniqueDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration technique
ChEMBL 588 7 3 6 4.3 CNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2008.07.055
44421279 91931 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]des-arg10, leu9-kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-arg10, leu9-kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 442 7 2 6 5.2 COC(=O)c1ccc(C)cc1-c1ccc([C@@H](C)Nc2nccc(C)c2NC(=O)CC#N)cc1 10.1021/jm049394l
CHEMBL225133 91931 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]des-arg10, leu9-kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-arg10, leu9-kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 442 7 2 6 5.2 COC(=O)c1ccc(C)cc1-c1ccc([C@@H](C)Nc2nccc(C)c2NC(=O)CC#N)cc1 10.1021/jm049394l
57398978 76833 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells membrane after 90 mins by scintillation countingDisplacement of [3H]-DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells membrane after 90 mins by scintillation counting
ChEMBL 496 7 2 5 2.6 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN(C)C)ccc32)cc1 10.1016/j.bmcl.2011.11.112
CHEMBL1939757 76833 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells membrane after 90 mins by scintillation countingDisplacement of [3H]-DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells membrane after 90 mins by scintillation counting
ChEMBL 496 7 2 5 2.6 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN(C)C)ccc32)cc1 10.1016/j.bmcl.2011.11.112
57382967 133986 0 None - 1 Human 8.9 pKi = 8.9 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 554 7 2 8 3.8 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)C3(NC(=O)c4cccnc4)COC3)c(F)c2)no1 nan
CHEMBL3657637 133986 0 None - 1 Human 8.9 pKi = 8.9 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 554 7 2 8 3.8 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)C3(NC(=O)c4cccnc4)COC3)c(F)c2)no1 nan
11281533 71851 0 None - 1 Human 8.9 pKi = 8.9 Binding
Binding affinity against Human bradykinin receptor B1Binding affinity against Human bradykinin receptor B1
ChEMBL 418 7 2 6 4.1 COC(=O)C1CC=CCC1c1ccc(CNc2nccc(C)c2NC(=O)CC#N)cc1 10.1016/j.bmcl.2005.05.133
CHEMBL182378 71851 0 None - 1 Human 8.9 pKi = 8.9 Binding
Binding affinity against Human bradykinin receptor B1Binding affinity against Human bradykinin receptor B1
ChEMBL 418 7 2 6 4.1 COC(=O)C1CC=CCC1c1ccc(CNc2nccc(C)c2NC(=O)CC#N)cc1 10.1016/j.bmcl.2005.05.133
24895550 180704 0 None - 1 Human 8.9 pKi = 8.9 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 481 8 2 7 3.8 O=C(Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccn2)cc1)OCC1CCCO1 10.1021/jm800199h
CHEMBL454086 180704 0 None - 1 Human 8.9 pKi = 8.9 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 481 8 2 7 3.8 O=C(Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccn2)cc1)OCC1CCCO1 10.1021/jm800199h
44455549 162334 0 None - 1 Human 8.9 pKi = 8.9 Binding
Binding affinity to human bradykinin B1 receptor expressed in rat CNSBinding affinity to human bradykinin B1 receptor expressed in rat CNS
ChEMBL 506 7 2 3 5.6 CCOc1c(Cl)cc(Cl)cc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1016/j.bmcl.2007.11.057
CHEMBL404328 162334 0 None - 1 Human 8.9 pKi = 8.9 Binding
Binding affinity to human bradykinin B1 receptor expressed in rat CNSBinding affinity to human bradykinin B1 receptor expressed in rat CNS
ChEMBL 506 7 2 3 5.6 CCOc1c(Cl)cc(Cl)cc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1016/j.bmcl.2007.11.057
11215913 143317 0 None 26915 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cells
ChEMBL 646 9 2 6 4.9 CN1c2cc(CN3CCCCC3)ccc2[C@@H](NC(=O)C[C@@H](NS(=O)(=O)c2ccc3ccccc3c2)c2ccccc2)CS1(=O)=O 10.1021/jm061224g
CHEMBL373654 143317 0 None 26915 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cells
ChEMBL 646 9 2 6 4.9 CN1c2cc(CN3CCCCC3)ccc2[C@@H](NC(=O)C[C@@H](NS(=O)(=O)c2ccc3ccccc3c2)c2ccccc2)CS1(=O)=O 10.1021/jm061224g
11017305 67101 0 None - 1 Human 8.9 pKi = 8.9 Binding
Inhibition of human bradykinin B1 receptorInhibition of human bradykinin B1 receptor
ChEMBL 579 7 2 6 5.7 CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCN(c4ccncc4)CC3)cc2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm034020y
CHEMBL1744084 67101 0 None - 1 Human 8.9 pKi = 8.9 Binding
Inhibition of human bradykinin B1 receptorInhibition of human bradykinin B1 receptor
ChEMBL 579 7 2 6 5.7 CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCN(c4ccncc4)CC3)cc2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm034020y
16102920 89985 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 500 7 2 4 4.7 CCOC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1021/jm061094b
CHEMBL218553 89985 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 500 7 2 4 4.7 CCOC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1021/jm061094b
11050306 67100 0 None 1 2 Human 8.9 pKi = 8.9 Binding
Inhibition of human bradykinin B1 receptorInhibition of human bradykinin B1 receptor
ChEMBL 606 9 2 5 6.5 CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCC(N4CCCCC4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 10.1021/jm034020y
CHEMBL1744083 67100 0 None 1 2 Human 8.9 pKi = 8.9 Binding
Inhibition of human bradykinin B1 receptorInhibition of human bradykinin B1 receptor
ChEMBL 606 9 2 5 6.5 CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCC(N4CCCCC4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 10.1021/jm034020y
10128412 94173 0 None - 1 Human 8.9 pKi = 8.9 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 510 6 2 5 4.9 Cc1nc(-c2ccc(Cl)cc2-c2ccc([C@@H](C)NC(=O)C3(NC(=O)C(F)(F)F)CC3)c(F)c2)no1 10.1016/j.bmcl.2007.04.040
CHEMBL233351 94173 0 None - 1 Human 8.9 pKi = 8.9 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 510 6 2 5 4.9 Cc1nc(-c2ccc(Cl)cc2-c2ccc([C@@H](C)NC(=O)C3(NC(=O)C(F)(F)F)CC3)c(F)c2)no1 10.1016/j.bmcl.2007.04.040
57382838 133971 0 None - 1 Human 8.9 pKi = 8.9 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 574 8 2 10 3.4 COc1cc(C(=O)NC2(C(=O)N[C@H](C)c3ncc(-c4cc(Cl)cc(F)c4-c4noc(C)n4)cc3F)COC2)on1 nan
CHEMBL3657622 133971 0 None - 1 Human 8.9 pKi = 8.9 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 574 8 2 10 3.4 COc1cc(C(=O)NC2(C(=O)N[C@H](C)c3ncc(-c4cc(Cl)cc(F)c4-c4noc(C)n4)cc3F)COC2)on1 nan
57382965 133984 0 None - 1 Human 8.9 pKi = 8.9 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 569 7 3 9 3.4 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)C3(NC(=O)c4cncc(N)c4)COC3)c(F)c2)no1 nan
CHEMBL3657635 133984 0 None - 1 Human 8.9 pKi = 8.9 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 569 7 3 9 3.4 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)C3(NC(=O)c4cncc(N)c4)COC3)c(F)c2)no1 nan
57383098 133999 0 None - 1 Human 8.9 pKi = 8.9 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 573 8 2 10 2.8 COc1cc(C(=O)NC2(C(=O)N[C@H](C)c3ccc(-c4cc(Cl)cc(F)c4-c4nnn(C)n4)cc3F)COC2)on1 nan
CHEMBL3657650 133999 0 None - 1 Human 8.9 pKi = 8.9 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 573 8 2 10 2.8 COc1cc(C(=O)NC2(C(=O)N[C@H](C)c3ccc(-c4cc(Cl)cc(F)c4-c4nnn(C)n4)cc3F)COC2)on1 nan
44411062 84096 0 None - 1 Human 8.9 pKi = 8.9 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 522 9 1 6 5.0 CCCCN1CCN(C(=O)c2ccc(NCc3ccc(-c4cccc(F)c4C(=O)OC)cc3F)nc2)CC1 10.1016/j.bmcl.2006.01.112
CHEMBL208320 84096 0 None - 1 Human 8.9 pKi = 8.9 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 522 9 1 6 5.0 CCCCN1CCN(C(=O)c2ccc(NCc3ccc(-c4cccc(F)c4C(=O)OC)cc3F)nc2)CC1 10.1016/j.bmcl.2006.01.112
11307467 162002 0 None - 1 Human 8.9 pKi = 8.9 Binding
Binding affinity to human bradykinin B1 receptor expressed in rat CNSBinding affinity to human bradykinin B1 receptor expressed in rat CNS
ChEMBL 556 9 2 6 5.3 Cc1cc(C(=O)NC2(C(=O)N[C@H](C)c3ncc(-c4cc(Cl)cc(Cl)c4OCC(F)F)cc3F)CC2)no1 10.1016/j.bmcl.2007.11.057
CHEMBL402630 162002 0 None - 1 Human 8.9 pKi = 8.9 Binding
Binding affinity to human bradykinin B1 receptor expressed in rat CNSBinding affinity to human bradykinin B1 receptor expressed in rat CNS
ChEMBL 556 9 2 6 5.3 Cc1cc(C(=O)NC2(C(=O)N[C@H](C)c3ncc(-c4cc(Cl)cc(Cl)c4OCC(F)F)cc3F)CC2)no1 10.1016/j.bmcl.2007.11.057
16102899 91121 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 480 5 2 2 5.0 C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)CC1)c1ccc(-c2cccc(F)c2C(F)(F)F)cc1F 10.1021/jm061094b
CHEMBL221695 91121 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 480 5 2 2 5.0 C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)CC1)c1ccc(-c2cccc(F)c2C(F)(F)F)cc1F 10.1021/jm061094b
44432181 94531 0 None - 1 Human 8.8 pKi = 8.8 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 510 6 2 6 3.7 C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)CC1)c1ccc(-c2cc(Cl)ccc2-c2nnn(C)n2)cc1F 10.1016/j.bmcl.2007.04.040
CHEMBL233764 94531 0 None - 1 Human 8.8 pKi = 8.8 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 510 6 2 6 3.7 C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)CC1)c1ccc(-c2cc(Cl)ccc2-c2nnn(C)n2)cc1F 10.1016/j.bmcl.2007.04.040
16102907 168523 0 None 1 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 456 6 2 4 3.2 COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1021/jm061094b
CHEMBL413775 168523 0 None 1 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 456 6 2 4 3.2 COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1021/jm061094b
10233880 84229 0 None - 1 Human 8.8 pKi = 8.8 Binding
Binding affinity to B1 receptorBinding affinity to B1 receptor
ChEMBL 714 17 3 6 4.8 Cc1c(Cl)ccc(S(=O)(=O)N(CCc2ccccc2)CC(=O)NCC(=O)N(CCCCN2CCCC2)Cc2ccc(C(=N)N)cc2)c1Cl 10.1021/jm2016057
CHEMBL2087031 84229 0 None - 1 Human 8.8 pKi = 8.8 Binding
Binding affinity to B1 receptorBinding affinity to B1 receptor
ChEMBL 714 17 3 6 4.8 Cc1c(Cl)ccc(S(=O)(=O)N(CCc2ccccc2)CC(=O)NCC(=O)N(CCCCN2CCCC2)Cc2ccc(C(=N)N)cc2)c1Cl 10.1021/jm2016057
44411358 82305 0 None - 1 Human 8.8 pKi = 8.8 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 534 7 1 6 5.1 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(C4CCCC4)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
CHEMBL204356 82305 0 None - 1 Human 8.8 pKi = 8.8 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 534 7 1 6 5.1 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(C4CCCC4)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
44411364 84512 0 None - 1 Human 8.8 pKi = 8.8 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 522 8 1 6 5.0 CCC(C)N1CCN(C(=O)c2ccc(NCc3ccc(-c4cccc(F)c4C(=O)OC)cc3F)nc2)CC1 10.1016/j.bmcl.2006.01.112
CHEMBL208991 84512 0 None - 1 Human 8.8 pKi = 8.8 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 522 8 1 6 5.0 CCC(C)N1CCN(C(=O)c2ccc(NCc3ccc(-c4cccc(F)c4C(=O)OC)cc3F)nc2)CC1 10.1016/j.bmcl.2006.01.112
44411101 147655 0 None - 1 Human 8.8 pKi = 8.8 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 522 8 1 6 4.8 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(CC(C)C)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
CHEMBL381974 147655 0 None - 1 Human 8.8 pKi = 8.8 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 522 8 1 6 4.8 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(CC(C)C)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
16102907 168523 0 None 1 2 Human 8.8 pKi = 8.8 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 456 6 2 4 3.2 COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1016/j.bmcl.2007.11.050
CHEMBL413775 168523 0 None 1 2 Human 8.8 pKi = 8.8 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 456 6 2 4 3.2 COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1016/j.bmcl.2007.11.050
44455089 104200 0 None - 1 Human 8.8 pKi = 8.8 Binding
Binding affinity to human bradykinin B1 receptor expressed in rat CNSBinding affinity to human bradykinin B1 receptor expressed in rat CNS
ChEMBL 507 7 2 4 5.0 CCOc1c(Cl)cc(Cl)cc1-c1cnc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1016/j.bmcl.2007.11.057
CHEMBL269963 104200 0 None - 1 Human 8.8 pKi = 8.8 Binding
Binding affinity to human bradykinin B1 receptor expressed in rat CNSBinding affinity to human bradykinin B1 receptor expressed in rat CNS
ChEMBL 507 7 2 4 5.0 CCOc1c(Cl)cc(Cl)cc1-c1cnc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1016/j.bmcl.2007.11.057
44455366 162116 0 None - 1 Human 8.8 pKi = 8.8 Binding
Binding affinity to human bradykinin B1 receptor expressed in rat CNSBinding affinity to human bradykinin B1 receptor expressed in rat CNS
ChEMBL 543 8 2 4 5.2 C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)CC1)c1ncc(-c2cc(Cl)cc(Cl)c2OCC(F)F)cc1F 10.1016/j.bmcl.2007.11.057
CHEMBL403202 162116 0 None - 1 Human 8.8 pKi = 8.8 Binding
Binding affinity to human bradykinin B1 receptor expressed in rat CNSBinding affinity to human bradykinin B1 receptor expressed in rat CNS
ChEMBL 543 8 2 4 5.2 C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)CC1)c1ncc(-c2cc(Cl)cc(Cl)c2OCC(F)F)cc1F 10.1016/j.bmcl.2007.11.057
44561786 179442 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells
ChEMBL 580 9 1 4 7.0 O=C(CC(CS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2008.07.108
CHEMBL449789 179442 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells
ChEMBL 580 9 1 4 7.0 O=C(CC(CS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2008.07.108
44432212 151947 0 None - 1 Human 8.8 pKi = 8.8 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 544 6 2 6 4.4 C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)CC1)c1ccc(-c2cc(Cl)cc(Cl)c2-c2nnn(C)n2)cc1F 10.1016/j.bmcl.2007.04.040
CHEMBL391227 151947 0 None - 1 Human 8.8 pKi = 8.8 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 544 6 2 6 4.4 C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)CC1)c1ccc(-c2cc(Cl)cc(Cl)c2-c2nnn(C)n2)cc1F 10.1016/j.bmcl.2007.04.040
57382794 133964 0 None - 1 Human 8.8 pKi = 8.8 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 512 7 2 7 3.1 COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)c3cncnc3)COC2)c(F)c1 nan
CHEMBL3657615 133964 0 None - 1 Human 8.8 pKi = 8.8 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 512 7 2 7 3.1 COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)c3cncnc3)COC2)c(F)c1 nan
57382877 133973 0 None - 1 Human 8.8 pKi = 8.8 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 575 7 2 10 3.6 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)C3(NC(=O)c4snnc4C)COC3)c(F)c2)no1 nan
CHEMBL3657624 133973 0 None - 1 Human 8.8 pKi = 8.8 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 575 7 2 10 3.6 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)C3(NC(=O)c4snnc4C)COC3)c(F)c2)no1 nan
57382881 133977 0 None - 1 Human 8.8 pKi = 8.8 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 558 7 2 10 2.5 Cc1cc(C(=O)NC2(C(=O)N[C@H](C)c3ncc(-c4cc(Cl)cc(F)c4-c4nnn(C)n4)cc3F)COC2)on1 nan
CHEMBL3657628 133977 0 None - 1 Human 8.8 pKi = 8.8 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 558 7 2 10 2.5 Cc1cc(C(=O)NC2(C(=O)N[C@H](C)c3ncc(-c4cc(Cl)cc(F)c4-c4nnn(C)n4)cc3F)COC2)on1 nan
16108960 176038 0 None 30902 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cells
ChEMBL 567 9 2 4 6.0 O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCc2cc(CN3CCCCC3)ccc21 10.1021/jm061224g
CHEMBL441188 176038 0 None 30902 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cells
ChEMBL 567 9 2 4 6.0 O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCc2cc(CN3CCCCC3)ccc21 10.1021/jm061224g
10196170 143333 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 520 7 2 4 4.4 COC(=O)c1c(F)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)C(F)(F)F)CC2)c(F)c1 10.1021/jm061094b
CHEMBL373803 143333 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 520 7 2 4 4.4 COC(=O)c1c(F)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)C(F)(F)F)CC2)c(F)c1 10.1021/jm061094b
11340940 84300 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 496 9 0 7 1.2 COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCN(C3CCN(C)CC3)CC2)c(C)c1 10.1021/jm2016057
CHEMBL2087421 84300 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 496 9 0 7 1.2 COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCN(C3CCN(C)CC3)CC2)c(C)c1 10.1021/jm2016057
44580047 199371 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]des-arg10leu9kallidin from human bradykinin B1 receptor expressed in CHO cells by Wallac beta-plate scintillation countingDisplacement of [3H]des-arg10leu9kallidin from human bradykinin B1 receptor expressed in CHO cells by Wallac beta-plate scintillation counting
ChEMBL 496 5 2 8 1.9 C[C@@H](NC(=O)C1(O)CC[S+]([O-])C1)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F 10.1016/j.bmcl.2008.07.126
CHEMBL521454 199371 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]des-arg10leu9kallidin from human bradykinin B1 receptor expressed in CHO cells by Wallac beta-plate scintillation countingDisplacement of [3H]des-arg10leu9kallidin from human bradykinin B1 receptor expressed in CHO cells by Wallac beta-plate scintillation counting
ChEMBL 496 5 2 8 1.9 C[C@@H](NC(=O)C1(O)CC[S+]([O-])C1)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F 10.1016/j.bmcl.2008.07.126
57395448 76832 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells membrane after 90 mins by scintillation countingDisplacement of [3H]-DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells membrane after 90 mins by scintillation counting
ChEMBL 468 6 3 5 2.0 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN)ccc32)cc1 10.1016/j.bmcl.2011.11.112
CHEMBL1939756 76832 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells membrane after 90 mins by scintillation countingDisplacement of [3H]-DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells membrane after 90 mins by scintillation counting
ChEMBL 468 6 3 5 2.0 Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN)ccc32)cc1 10.1016/j.bmcl.2011.11.112
57382922 133978 0 None - 1 Human 8.8 pKi = 8.8 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 544 6 2 7 3.1 C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)COC1)c1ccc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F nan
CHEMBL3657629 133978 0 None - 1 Human 8.8 pKi = 8.8 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 544 6 2 7 3.1 C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)COC1)c1ccc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F nan
44411054 83850 0 None - 1 Human 8.8 pKi = 8.8 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 508 8 1 6 4.6 CCCN1CCN(C(=O)c2ccc(NCc3ccc(-c4cccc(F)c4C(=O)OC)cc3F)nc2)CC1 10.1016/j.bmcl.2006.01.112
CHEMBL207378 83850 0 None - 1 Human 8.8 pKi = 8.8 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 508 8 1 6 4.6 CCCN1CCN(C(=O)c2ccc(NCc3ccc(-c4cccc(F)c4C(=O)OC)cc3F)nc2)CC1 10.1016/j.bmcl.2006.01.112
44411093 147109 0 None - 1 Human 8.8 pKi = 8.8 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 548 8 1 6 5.4 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(CC4CCCC4)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
CHEMBL380679 147109 0 None - 1 Human 8.8 pKi = 8.8 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 548 8 1 6 5.4 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(CC4CCCC4)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
23627521 80633 0 None - 1 Human 8.8 pKi = 8.8 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 648 9 2 6 6.0 COc1cccc2c1-c1ccccc1N(S(=O)(=O)c1ccc(Cl)c(Cl)c1)C2CC(=O)NCCc1ccc(C2=NCCN2)cc1 10.1016/j.bmcl.2012.03.065
CHEMBL2018873 80633 0 None - 1 Human 8.8 pKi = 8.8 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 648 9 2 6 6.0 COc1cccc2c1-c1ccccc1N(S(=O)(=O)c1ccc(Cl)c(Cl)c1)C2CC(=O)NCCc1ccc(C2=NCCN2)cc1 10.1016/j.bmcl.2012.03.065
44587182 195469 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration techniqueDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration technique
ChEMBL 602 7 2 6 4.6 CN(C)Cc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2008.07.055
CHEMBL504119 195469 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration techniqueDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration technique
ChEMBL 602 7 2 6 4.6 CN(C)Cc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2008.07.055
11663809 180380 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells
ChEMBL 536 8 3 6 3.5 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1ccc2ccccc2c1 10.1016/j.bmcl.2008.07.108
CHEMBL453339 180380 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells
ChEMBL 536 8 3 6 3.5 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1ccc2ccccc2c1 10.1016/j.bmcl.2008.07.108
44432222 94016 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 535 7 2 5 4.8 CCOC(=O)c1c(Cl)cc(Cl)cc1-c1cnc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1016/j.bmcl.2007.04.040
CHEMBL232946 94016 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 535 7 2 5 4.8 CCOC(=O)c1c(Cl)cc(Cl)cc1-c1cnc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1016/j.bmcl.2007.04.040
11620238 79812 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 497 7 2 5 4.1 COC(=O)c1ccccc1-c1ccc(CNC(=O)C2(NC(=O)c3cncc(C(F)(F)F)c3)CC2)cc1 10.1021/jm0511280
CHEMBL201041 79812 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 497 7 2 5 4.1 COC(=O)c1ccccc1-c1ccc(CNC(=O)C2(NC(=O)c3cncc(C(F)(F)F)c3)CC2)cc1 10.1021/jm0511280
44455853 175494 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity to human bradykinin B1 receptor expressed in rat CNSBinding affinity to human bradykinin B1 receptor expressed in rat CNS
ChEMBL 560 7 2 3 6.1 C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)CC1)c1ccc(-c2cc(Cl)cc(Cl)c2OCC(F)(F)F)cc1F 10.1016/j.bmcl.2007.11.057
CHEMBL436854 175494 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity to human bradykinin B1 receptor expressed in rat CNSBinding affinity to human bradykinin B1 receptor expressed in rat CNS
ChEMBL 560 7 2 3 6.1 C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)CC1)c1ccc(-c2cc(Cl)cc(Cl)c2OCC(F)(F)F)cc1F 10.1016/j.bmcl.2007.11.057
44587188 200150 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration techniqueDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration technique
ChEMBL 562 7 3 6 4.1 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccccc1 10.1016/j.bmcl.2008.07.055
CHEMBL525092 200150 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration techniqueDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration technique
ChEMBL 562 7 3 6 4.1 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccccc1 10.1016/j.bmcl.2008.07.055
71454501 85784 0 None - 1 Human 8.7 pKi = 8.7 Binding
Inhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cellsInhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cells
ChEMBL 471 7 2 5 5.9 COC(=O)c1ccccc1-c1ccc([C@@H](C)Nc2nccc(C)c2NC(=O)CC(F)(F)F)cc1 10.1016/j.bmcl.2005.02.077
CHEMBL2113087 85784 0 None - 1 Human 8.7 pKi = 8.7 Binding
Inhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cellsInhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cells
ChEMBL 471 7 2 5 5.9 COC(=O)c1ccccc1-c1ccc([C@@H](C)Nc2nccc(C)c2NC(=O)CC(F)(F)F)cc1 10.1016/j.bmcl.2005.02.077
44432198 154087 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 534 7 2 4 5.4 CCOC(=O)c1c(Cl)cc(Cl)cc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1016/j.bmcl.2007.04.040
CHEMBL392903 154087 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 534 7 2 4 5.4 CCOC(=O)c1c(Cl)cc(Cl)cc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1016/j.bmcl.2007.04.040
16726096 162047 9 None 2 4 Human 8.7 pKi = 8.7 Binding
Binding affinity to monkey bradykinin B1 receptor expressed in CHO cellsBinding affinity to monkey bradykinin B1 receptor expressed in CHO cells
ChEMBL 490 5 2 6 4.5 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)[C@@](C)(O)C(F)(F)F)c(F)c2)no1 10.1016/j.bmcl.2007.11.050
CHEMBL402831 162047 9 None 2 4 Human 8.7 pKi = 8.7 Binding
Binding affinity to monkey bradykinin B1 receptor expressed in CHO cellsBinding affinity to monkey bradykinin B1 receptor expressed in CHO cells
ChEMBL 490 5 2 6 4.5 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)[C@@](C)(O)C(F)(F)F)c(F)c2)no1 10.1016/j.bmcl.2007.11.050
11398971 102179 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity to human bradykinin B1 receptor expressed in rat CNSBinding affinity to human bradykinin B1 receptor expressed in rat CNS
ChEMBL 570 10 2 6 5.5 CCc1cc(C(=O)NC2(C(=O)N[C@H](C)c3ncc(-c4cc(Cl)cc(Cl)c4OCC(F)F)cc3F)CC2)no1 10.1016/j.bmcl.2007.11.057
CHEMBL256903 102179 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity to human bradykinin B1 receptor expressed in rat CNSBinding affinity to human bradykinin B1 receptor expressed in rat CNS
ChEMBL 570 10 2 6 5.5 CCc1cc(C(=O)NC2(C(=O)N[C@H](C)c3ncc(-c4cc(Cl)cc(Cl)c4OCC(F)F)cc3F)CC2)no1 10.1016/j.bmcl.2007.11.057
16102923 91398 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 484 7 2 3 5.1 CCC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1021/jm061094b
CHEMBL222159 91398 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 484 7 2 3 5.1 CCC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1021/jm061094b
11050306 67100 0 None -1 2 Rat 8.7 pKi = 8.7 Binding
Compound was tested for inhibition against rat Bradykinin receptor B1Compound was tested for inhibition against rat Bradykinin receptor B1
ChEMBL 606 9 2 5 6.5 CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCC(N4CCCCC4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 10.1021/jm034020y
CHEMBL1744083 67100 0 None -1 2 Rat 8.7 pKi = 8.7 Binding
Compound was tested for inhibition against rat Bradykinin receptor B1Compound was tested for inhibition against rat Bradykinin receptor B1
ChEMBL 606 9 2 5 6.5 CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCC(N4CCCCC4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 10.1021/jm034020y
659 9673 17 None -1 2 Human 8.0 pKi = 8 Binding
Binding affinity for Bradykinin receptor B1 expressed in HEK293 cellsBinding affinity for Bradykinin receptor B1 expressed in HEK293 cells
ChEMBL 659 9 1 7 3.6 CN1CCN(CC1)C(=O)C1CCN(CC1)S(=O)(=O)c1ccc(c(c1)C(=O)N1CCOCC1)NCC(c1ccccc1)c1ccccc1 10.1021/jm049747g
9831083 9673 17 None -1 2 Human 8.0 pKi = 8 Binding
Binding affinity for Bradykinin receptor B1 expressed in HEK293 cellsBinding affinity for Bradykinin receptor B1 expressed in HEK293 cells
ChEMBL 659 9 1 7 3.6 CN1CCN(CC1)C(=O)C1CCN(CC1)S(=O)(=O)c1ccc(c(c1)C(=O)N1CCOCC1)NCC(c1ccccc1)c1ccccc1 10.1021/jm049747g
CHEMBL273869 9673 17 None -1 2 Human 8.0 pKi = 8 Binding
Binding affinity for Bradykinin receptor B1 expressed in HEK293 cellsBinding affinity for Bradykinin receptor B1 expressed in HEK293 cells
ChEMBL 659 9 1 7 3.6 CN1CCN(CC1)C(=O)C1CCN(CC1)S(=O)(=O)c1ccc(c(c1)C(=O)N1CCOCC1)NCC(c1ccccc1)c1ccccc1 10.1021/jm049747g
9961595 71378 0 None - 1 Human 8.0 pKi = 8 Binding
Binding affinity for Bradykinin receptor B1 expressed in HEK293 cellsBinding affinity for Bradykinin receptor B1 expressed in HEK293 cells
ChEMBL 687 10 1 7 4.4 CC(C)N1CCN(C(=O)C2CCN(S(=O)(=O)c3ccc(NCC(c4ccccc4)c4ccccc4)c(C(=O)N4CCOCC4)c3)CC2)CC1 10.1021/jm049747g
CHEMBL181695 71378 0 None - 1 Human 8.0 pKi = 8 Binding
Binding affinity for Bradykinin receptor B1 expressed in HEK293 cellsBinding affinity for Bradykinin receptor B1 expressed in HEK293 cells
ChEMBL 687 10 1 7 4.4 CC(C)N1CCN(C(=O)C2CCN(S(=O)(=O)c3ccc(NCC(c4ccccc4)c4ccccc4)c(C(=O)N4CCOCC4)c3)CC2)CC1 10.1021/jm049747g
11377529 73478 0 None - 1 Human 8.0 pKi = 8 Binding
Binding affinity for Bradykinin receptor B1 expressed in HEK293 cellsBinding affinity for Bradykinin receptor B1 expressed in HEK293 cells
ChEMBL 706 19 2 8 3.8 CN(C)CCCN(CCCN(C)C)C(=O)CCNS(=O)(=O)c1ccc(NCC(c2ccccc2)c2ccccc2)c(C(=O)N2CCOCC2)c1 10.1021/jm049747g
CHEMBL185551 73478 0 None - 1 Human 8.0 pKi = 8 Binding
Binding affinity for Bradykinin receptor B1 expressed in HEK293 cellsBinding affinity for Bradykinin receptor B1 expressed in HEK293 cells
ChEMBL 706 19 2 8 3.8 CN(C)CCCN(CCCN(C)C)C(=O)CCNS(=O)(=O)c1ccc(NCC(c2ccccc2)c2ccccc2)c(C(=O)N2CCOCC2)c1 10.1021/jm049747g
11479448 134324 0 None - 1 Human 8.0 pKi = 8 Binding
Binding affinity for Bradykinin receptor B1 expressed in HEK293 cellsBinding affinity for Bradykinin receptor B1 expressed in HEK293 cells
ChEMBL 678 17 1 8 5.0 CN(C)CCCN(CCCN(C)C)C(=O)C1CCN(S(=O)(=O)c2ccc(NCC(c3ccccc3)c3ccccc3)c([N+](=O)[O-])c2)CC1 10.1021/jm049747g
CHEMBL366294 134324 0 None - 1 Human 8.0 pKi = 8 Binding
Binding affinity for Bradykinin receptor B1 expressed in HEK293 cellsBinding affinity for Bradykinin receptor B1 expressed in HEK293 cells
ChEMBL 678 17 1 8 5.0 CN(C)CCCN(CCCN(C)C)C(=O)C1CCN(S(=O)(=O)c2ccc(NCC(c3ccccc3)c3ccccc3)c([N+](=O)[O-])c2)CC1 10.1021/jm049747g
16221229 92343 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 605 10 3 5 5.5 O=C(C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1)N[C@@H]1CCOc2cc(CNC3CCC3)ccc21 10.1021/jm070055c
CHEMBL227977 92343 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 605 10 3 5 5.5 O=C(C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1)N[C@@H]1CCOc2cc(CNC3CCC3)ccc21 10.1021/jm070055c
68868975 84305 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 498 13 0 7 1.4 CCN(CC)CCN1CCN(C(=O)COCCN(C)S(=O)(=O)c2c(C)cc(OC)cc2C)CC1 10.1021/jm2016057
CHEMBL2087426 84305 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 498 13 0 7 1.4 CCN(CC)CCN1CCN(C(=O)COCCN(C)S(=O)(=O)c2c(C)cc(OC)cc2C)CC1 10.1021/jm2016057
11214151 84307 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 497 11 0 6 2.8 COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCC(C(C)(C)CN(C)C)CC2)c(C)c1 10.1021/jm2016057
CHEMBL2087428 84307 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 497 11 0 6 2.8 COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCC(C(C)(C)CN(C)C)CC2)c(C)c1 10.1021/jm2016057
16102919 89941 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 452 6 2 4 3.7 COC(=O)c1ccccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1021/jm061094b
CHEMBL218319 89941 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 452 6 2 4 3.7 COC(=O)c1ccccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1021/jm061094b
10168110 84228 0 None - 1 Human 7.0 pKi = 7 Binding
Binding affinity to B1 receptorBinding affinity to B1 receptor
ChEMBL 625 15 3 6 3.2 Cc1c(Cl)ccc(S(=O)(=O)N(CCc2ccccc2)CC(=O)NCC(=O)N(CCCCN)CC2CCNCC2)c1Cl 10.1021/jm2016057
CHEMBL2087030 84228 0 None - 1 Human 7.0 pKi = 7 Binding
Binding affinity to B1 receptorBinding affinity to B1 receptor
ChEMBL 625 15 3 6 3.2 Cc1c(Cl)ccc(S(=O)(=O)N(CCc2ccccc2)CC(=O)NCC(=O)N(CCCCN)CC2CCNCC2)c1Cl 10.1021/jm2016057
44561641 193503 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells
ChEMBL 520 8 2 5 4.5 O=C(C[C@@H](O)CS(=O)(=O)c1ccc2ccccc2c1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2008.07.108
CHEMBL488677 193503 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells
ChEMBL 520 8 2 5 4.5 O=C(C[C@@H](O)CS(=O)(=O)c1ccc2ccccc2c1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2008.07.108
44411252 83665 0 None - 1 Human 5.0 pKi = 5 Binding
Binding affinity to human BK1 receptor Q295 mutantBinding affinity to human BK1 receptor Q295 mutant
ChEMBL 543 7 1 7 4.8 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(c4ccccn4)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
CHEMBL207011 83665 0 None - 1 Human 5.0 pKi = 5 Binding
Binding affinity to human BK1 receptor Q295 mutantBinding affinity to human BK1 receptor Q295 mutant
ChEMBL 543 7 1 7 4.8 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(c4ccccn4)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
10875606 69847 0 None - 1 Human 6.0 pKi = 6.0 Binding
Inhibition of human bradykinin B1 receptorInhibition of human bradykinin B1 receptor
ChEMBL 584 7 2 5 6.4 CCCN1C(=O)[C@@H](NC(=O)Nc2ccc(N3CCC(N4CCCCC4)CC3)cc2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm034020y
CHEMBL1788318 69847 0 None - 1 Human 6.0 pKi = 6.0 Binding
Inhibition of human bradykinin B1 receptorInhibition of human bradykinin B1 receptor
ChEMBL 584 7 2 5 6.4 CCCN1C(=O)[C@@H](NC(=O)Nc2ccc(N3CCC(N4CCCCC4)CC3)cc2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm034020y
44455182 162166 0 None - 1 Human 6.0 pKi = 6.0 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 349 5 2 4 2.4 COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)[C@@H](C)O)c(F)c1 10.1016/j.bmcl.2007.11.050
CHEMBL403519 162166 0 None - 1 Human 6.0 pKi = 6.0 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 349 5 2 4 2.4 COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)[C@@H](C)O)c(F)c1 10.1016/j.bmcl.2007.11.050
11476944 84304 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 470 11 0 7 0.7 COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCN(CCN(C)C)CC2)c(C)c1 10.1021/jm2016057
CHEMBL2087425 84304 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 470 11 0 7 0.7 COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCN(CCN(C)C)CC2)c(C)c1 10.1021/jm2016057
24895114 185759 3 None - 1 Human 7.0 pKi = 7.0 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 428 6 2 4 4.3 CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2cccc(Cl)c2)cc1 10.1021/jm800199h
CHEMBL470693 185759 3 None - 1 Human 7.0 pKi = 7.0 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 428 6 2 4 4.3 CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2cccc(Cl)c2)cc1 10.1021/jm800199h
44455150 104195 0 None - 1 Human 7.0 pKi = 7.0 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 403 5 2 4 3.0 COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)[C@@H](O)C(F)(F)F)c(F)c1 10.1016/j.bmcl.2007.11.050
CHEMBL269949 104195 0 None - 1 Human 7.0 pKi = 7.0 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 403 5 2 4 3.0 COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)[C@@H](O)C(F)(F)F)c(F)c1 10.1016/j.bmcl.2007.11.050
44455227 102153 0 None - 1 Human 6.0 pKi = 6.0 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 391 7 2 4 3.6 CCC(O)(CC)C(=O)NCc1ccc(-c2cccc(F)c2C(=O)OC)cc1F 10.1016/j.bmcl.2007.11.050
CHEMBL256793 102153 0 None - 1 Human 6.0 pKi = 6.0 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 391 7 2 4 3.6 CCC(O)(CC)C(=O)NCc1ccc(-c2cccc(F)c2C(=O)OC)cc1F 10.1016/j.bmcl.2007.11.050
44570026 183097 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]desArg from human B1 in human WI 38 cellsDisplacement of [3H]desArg from human B1 in human WI 38 cells
ChEMBL 508 11 2 5 3.3 O=C(O)CCNC(=O)CN(CCOc1cccc(Cl)c1)S(=O)(=O)c1ccc(Cl)cc1Cl 10.1016/j.bmcl.2008.11.005
CHEMBL459532 183097 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]desArg from human B1 in human WI 38 cellsDisplacement of [3H]desArg from human B1 in human WI 38 cells
ChEMBL 508 11 2 5 3.3 O=C(O)CCNC(=O)CN(CCOc1cccc(Cl)c1)S(=O)(=O)c1ccc(Cl)cc1Cl 10.1016/j.bmcl.2008.11.005
60142437 132684 0 None - 1 Human 8.0 pKi = 8.0 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 540 5 2 5 5.0 Cc1nc(-c2c(F)cc(Cl)cc2-c2cc(F)c3c(c2)CCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 nan
CHEMBL3648466 132684 0 None - 1 Human 8.0 pKi = 8.0 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 540 5 2 5 5.0 Cc1nc(-c2c(F)cc(Cl)cc2-c2cc(F)c3c(c2)CCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 nan
44392025 71604 0 None - 1 Human 8.0 pKi = 8.0 Binding
Binding affinity against Human bradykinin receptor B1Binding affinity against Human bradykinin receptor B1
ChEMBL 414 7 2 6 4.3 COC(=O)c1ccccc1-c1ccc(CNc2nccc(C)c2NC(=O)CC#N)cc1 10.1016/j.bmcl.2005.05.133
CHEMBL181968 71604 0 None - 1 Human 8.0 pKi = 8.0 Binding
Binding affinity against Human bradykinin receptor B1Binding affinity against Human bradykinin receptor B1
ChEMBL 414 7 2 6 4.3 COC(=O)c1ccccc1-c1ccc(CNc2nccc(C)c2NC(=O)CC#N)cc1 10.1016/j.bmcl.2005.05.133
49863235 22002 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptorDisplacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptor
ChEMBL 613 10 3 4 6.7 C=C(CNC(C)(C)C)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2010.06.010
CHEMBL1210752 22002 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptorDisplacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptor
ChEMBL 613 10 3 4 6.7 C=C(CNC(C)(C)C)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2010.06.010
25181410 178993 1 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]Lys0-des-Arg9-BK at human bradykinin B1 receptor expressed in HEK293 cellsDisplacement of [3H]Lys0-des-Arg9-BK at human bradykinin B1 receptor expressed in HEK293 cells
ChEMBL 642 14 1 7 4.6 COc1cc(CN(CC(=O)NCc2ccccc2Cl)S(=O)(=O)c2ccc(CN3CCN(C)CC3)cc2)ccc1OCC(C)C 10.1021/jm1000776
CHEMBL447392 178993 1 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]Lys0-des-Arg9-BK at human bradykinin B1 receptor expressed in HEK293 cellsDisplacement of [3H]Lys0-des-Arg9-BK at human bradykinin B1 receptor expressed in HEK293 cells
ChEMBL 642 14 1 7 4.6 COc1cc(CN(CC(=O)NCc2ccccc2Cl)S(=O)(=O)c2ccc(CN3CCN(C)CC3)cc2)ccc1OCC(C)C 10.1021/jm1000776
25181410 178993 1 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]desArg from human B1 in human WI 38 cellsDisplacement of [3H]desArg from human B1 in human WI 38 cells
ChEMBL 642 14 1 7 4.6 COc1cc(CN(CC(=O)NCc2ccccc2Cl)S(=O)(=O)c2ccc(CN3CCN(C)CC3)cc2)ccc1OCC(C)C 10.1016/j.bmcl.2008.11.005
CHEMBL447392 178993 1 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]desArg from human B1 in human WI 38 cellsDisplacement of [3H]desArg from human B1 in human WI 38 cells
ChEMBL 642 14 1 7 4.6 COc1cc(CN(CC(=O)NCc2ccccc2Cl)S(=O)(=O)c2ccc(CN3CCN(C)CC3)cc2)ccc1OCC(C)C 10.1016/j.bmcl.2008.11.005
44402076 78470 0 None - 1 Human 8.0 pKi = 8.0 Binding
Inhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cellsInhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cells
ChEMBL 456 7 3 4 4.9 CNC(=O)c1ccccc1-c1ccc(CNc2nccc(C)c2NC(=O)CC(F)(F)F)cc1 10.1016/j.bmcl.2005.02.077
CHEMBL196494 78470 0 None - 1 Human 8.0 pKi = 8.0 Binding
Inhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cellsInhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cells
ChEMBL 456 7 3 4 4.9 CNC(=O)c1ccccc1-c1ccc(CNc2nccc(C)c2NC(=O)CC(F)(F)F)cc1 10.1016/j.bmcl.2005.02.077
44401932 78549 0 None - 1 Human 8.0 pKi = 8.0 Binding
Inhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cellsInhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cells
ChEMBL 400 7 2 6 4.0 COC(=O)c1ccccc1-c1ccc(CNc2ncccc2NC(=O)CC#N)cc1 10.1016/j.bmcl.2005.02.077
CHEMBL196698 78549 0 None - 1 Human 8.0 pKi = 8.0 Binding
Inhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cellsInhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cells
ChEMBL 400 7 2 6 4.0 COC(=O)c1ccccc1-c1ccc(CNc2ncccc2NC(=O)CC#N)cc1 10.1016/j.bmcl.2005.02.077
44402028 76597 0 None - 1 Human 7.9 pKi = 7.9 Binding
Inhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cellsInhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cells
ChEMBL 400 7 3 5 4.2 Cc1ccnc(NCc2ccc(-c3ccccc3C(=O)O)cc2)c1NC(=O)CC#N 10.1016/j.bmcl.2005.02.077
CHEMBL193684 76597 0 None - 1 Human 7.9 pKi = 7.9 Binding
Inhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cellsInhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cells
ChEMBL 400 7 3 5 4.2 Cc1ccnc(NCc2ccc(-c3ccccc3C(=O)O)cc2)c1NC(=O)CC#N 10.1016/j.bmcl.2005.02.077
16102908 148754 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 402 6 2 4 2.7 COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)C2(NC(C)=O)CC2)c(F)c1 10.1021/jm061094b
CHEMBL387331 148754 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 402 6 2 4 2.7 COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)C2(NC(C)=O)CC2)c(F)c1 10.1021/jm061094b
60141042 132715 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 537 6 2 8 3.8 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)c3ccno3)COC2)no1 nan
CHEMBL3648497 132715 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 537 6 2 8 3.8 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)c3ccno3)COC2)no1 nan
10388673 78178 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 443 7 2 5 5.0 COC(=O)c1ccccc1-c1ccc(CNc2ncccc2NC(=O)CC(F)(F)F)cc1 10.1021/jm0511280
CHEMBL195883 78178 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 443 7 2 5 5.0 COC(=O)c1ccccc1-c1ccc(CNc2ncccc2NC(=O)CC(F)(F)F)cc1 10.1021/jm0511280
57382747 133959 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 545 6 2 7 3.7 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)C3(NC(=O)C(F)(F)F)COC3)c(F)c2)no1 nan
CHEMBL3657610 133959 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 545 6 2 7 3.7 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)C3(NC(=O)C(F)(F)F)COC3)c(F)c2)no1 nan
44569937 195053 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]desArg from human B1 in human WI 38 cellsDisplacement of [3H]desArg from human B1 in human WI 38 cells
ChEMBL 612 13 1 6 4.6 CC(C)COc1ccc(CN(CC(=O)NCc2ccccc2Cl)S(=O)(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1 10.1016/j.bmcl.2008.11.005
CHEMBL499999 195053 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]desArg from human B1 in human WI 38 cellsDisplacement of [3H]desArg from human B1 in human WI 38 cells
ChEMBL 612 13 1 6 4.6 CC(C)COc1ccc(CN(CC(=O)NCc2ccccc2Cl)S(=O)(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1 10.1016/j.bmcl.2008.11.005
57383097 133998 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 535 10 2 6 3.5 COCC(=O)NC1(C(=O)N[C@H](C)c2ncc(-c3cc(Cl)cc(Cl)c3OCC(F)F)cc2F)COC1 nan
CHEMBL3657649 133998 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 535 10 2 6 3.5 COCC(=O)NC1(C(=O)N[C@H](C)c2ncc(-c3cc(Cl)cc(Cl)c3OCC(F)F)cc2F)COC1 nan
11719314 147287 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 448 7 2 4 3.7 COC(=O)c1ccccc1-c1ccc(CNC(=O)C2(NC(=O)CC(F)(F)F)CCC2)cc1 10.1021/jm0511280
CHEMBL381009 147287 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 448 7 2 4 3.7 COC(=O)c1ccccc1-c1ccc(CNC(=O)C2(NC(=O)CC(F)(F)F)CCC2)cc1 10.1021/jm0511280
16102909 90107 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 484 7 2 4 3.9 COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)C2(NC(=O)C(C)(Cl)Cl)CC2)c(F)c1 10.1021/jm061094b
CHEMBL219164 90107 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 484 7 2 4 3.9 COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)C2(NC(=O)C(C)(Cl)Cl)CC2)c(F)c1 10.1021/jm061094b
11225601 148805 0 None -239 3 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]des-arg10 kallidin from rat bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-arg10 kallidin from rat bradykinin B1 receptor expressed in CHO cells
ChEMBL 490 7 2 8 4.8 C[C@@H](Nc1nccc(Cl)c1NC(=O)CC#N)c1ccc(-c2cccc(F)c2-c2nnn(C)n2)cc1 10.1021/jm049394l
CHEMBL387638 148805 0 None -239 3 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]des-arg10 kallidin from rat bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-arg10 kallidin from rat bradykinin B1 receptor expressed in CHO cells
ChEMBL 490 7 2 8 4.8 C[C@@H](Nc1nccc(Cl)c1NC(=O)CC#N)c1ccc(-c2cccc(F)c2-c2nnn(C)n2)cc1 10.1021/jm049394l
44401887 76619 0 None - 1 Human 6.9 pKi = 6.9 Binding
Inhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cellsInhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cells
ChEMBL 389 7 2 5 4.5 CCC(=O)Nc1cccnc1NCc1ccc(-c2ccccc2C(=O)OC)cc1 10.1016/j.bmcl.2005.02.077
CHEMBL193819 76619 0 None - 1 Human 6.9 pKi = 6.9 Binding
Inhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cellsInhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cells
ChEMBL 389 7 2 5 4.5 CCC(=O)Nc1cccnc1NCc1ccc(-c2ccccc2C(=O)OC)cc1 10.1016/j.bmcl.2005.02.077
49863229 21996 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptorDisplacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptor
ChEMBL 627 10 3 5 5.4 C=C(CN1CC[C@@H](O)C1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2010.06.010
CHEMBL1210746 21996 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptorDisplacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptor
ChEMBL 627 10 3 5 5.4 C=C(CN1CC[C@@H](O)C1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2010.06.010
49863230 21997 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptorDisplacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptor
ChEMBL 597 10 2 4 6.0 C=C(CN1CCC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2010.06.010
CHEMBL1210747 21997 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptorDisplacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptor
ChEMBL 597 10 2 4 6.0 C=C(CN1CCC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2010.06.010
12085131 84233 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 508 8 1 5 3.5 Cc1c(Cl)ccc(S(=O)(=O)N(C)C/C=C/C(=O)N(C)Cc2ccc(C3=NCCN3)cc2)c1Cl 10.1021/jm2016057
CHEMBL2087036 84233 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 508 8 1 5 3.5 Cc1c(Cl)ccc(S(=O)(=O)N(C)C/C=C/C(=O)N(C)Cc2ccc(C3=NCCN3)cc2)c1Cl 10.1021/jm2016057
11466010 91189 0 None -1 3 Rat 7.9 pKi = 7.9 Binding
Displacement of [3H]des-arg10 kallidin from rat bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-arg10 kallidin from rat bradykinin B1 receptor expressed in CHO cells
ChEMBL 490 7 2 8 4.8 C[C@@H](Nc1nccc(Cl)c1NC(=O)CC#N)c1ccc(-c2cccc(F)c2-c2nnnn2C)cc1 10.1021/jm049394l
CHEMBL221984 91189 0 None -1 3 Rat 7.9 pKi = 7.9 Binding
Displacement of [3H]des-arg10 kallidin from rat bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-arg10 kallidin from rat bradykinin B1 receptor expressed in CHO cells
ChEMBL 490 7 2 8 4.8 C[C@@H](Nc1nccc(Cl)c1NC(=O)CC#N)c1ccc(-c2cccc(F)c2-c2nnnn2C)cc1 10.1021/jm049394l
10388673 78178 0 None - 1 Human 7.9 pKi = 7.9 Binding
Inhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cellsInhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cells
ChEMBL 443 7 2 5 5.0 COC(=O)c1ccccc1-c1ccc(CNc2ncccc2NC(=O)CC(F)(F)F)cc1 10.1016/j.bmcl.2005.02.077
CHEMBL195883 78178 0 None - 1 Human 7.9 pKi = 7.9 Binding
Inhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cellsInhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cells
ChEMBL 443 7 2 5 5.0 COC(=O)c1ccccc1-c1ccc(CNc2ncccc2NC(=O)CC(F)(F)F)cc1 10.1016/j.bmcl.2005.02.077
60141327 132725 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 554 6 2 10 3.3 Cc1nnc(C(=O)NC2(C(=O)NC3CSc4cc(-c5cc(Cl)cc(F)c5-c5nnn(C)n5)ccc43)CC2)o1 nan
CHEMBL3648507 132725 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 554 6 2 10 3.3 Cc1nnc(C(=O)NC2(C(=O)NC3CSc4cc(-c5cc(Cl)cc(F)c5-c5nnn(C)n5)ccc43)CC2)o1 nan
11685446 193483 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells
ChEMBL 554 8 3 6 3.7 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1cccc(Cl)c1Cl 10.1016/j.bmcl.2008.07.108
CHEMBL488501 193483 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells
ChEMBL 554 8 3 6 3.7 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1cccc(Cl)c1Cl 10.1016/j.bmcl.2008.07.108
16221227 149796 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 614 9 3 6 5.5 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(C#N)cc1 10.1021/jm070055c
CHEMBL389477 149796 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 614 9 3 6 5.5 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(C#N)cc1 10.1021/jm070055c
11224694 99541 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]DAKA from human bradykinin B1 receptor in IL1-beta stimulated IMR90 cellsDisplacement of [3H]DAKA from human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells
ChEMBL 447 6 3 4 3.4 O=C(Nc1[nH]nc(C(=O)NCCc2ccncc2)c1Br)c1ccccc1Cl 10.1021/jm051292n
CHEMBL243667 99541 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]DAKA from human bradykinin B1 receptor in IL1-beta stimulated IMR90 cellsDisplacement of [3H]DAKA from human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells
ChEMBL 447 6 3 4 3.4 O=C(Nc1[nH]nc(C(=O)NCCc2ccncc2)c1Br)c1ccccc1Cl 10.1021/jm051292n
44570136 190383 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]desArg from human B1 in human WI 38 cellsDisplacement of [3H]desArg from human B1 in human WI 38 cells
ChEMBL 514 12 1 5 3.7 COCCCNC(=O)CN(CCOc1ccc2c(c1)CCC2)S(=O)(=O)c1ccc(Cl)cc1Cl 10.1016/j.bmcl.2008.11.005
CHEMBL480203 190383 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]desArg from human B1 in human WI 38 cellsDisplacement of [3H]desArg from human B1 in human WI 38 cells
ChEMBL 514 12 1 5 3.7 COCCCNC(=O)CN(CCOc1ccc2c(c1)CCC2)S(=O)(=O)c1ccc(Cl)cc1Cl 10.1016/j.bmcl.2008.11.005
60142026 132670 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 480 5 2 4 4.1 COC(=O)c1c(Cl)cccc1-c1ccc2c(c1)CCC2NC(=O)C1(NC(=O)C(F)(F)F)CC1 nan
CHEMBL3648453 132670 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 480 5 2 4 4.1 COC(=O)c1c(Cl)cccc1-c1ccc2c(c1)CCC2NC(=O)C1(NC(=O)C(F)(F)F)CC1 nan
44455229 173662 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 363 5 2 4 2.8 COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)C(C)(C)O)c(F)c1 10.1016/j.bmcl.2007.11.050
CHEMBL428601 173662 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 363 5 2 4 2.8 COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)C(C)(C)O)c(F)c1 10.1016/j.bmcl.2007.11.050
44392138 129388 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity against Human bradykinin receptor B1Binding affinity against Human bradykinin receptor B1
ChEMBL 404 7 2 6 4.0 COC(=O)C1=C(c2ccc(CNc3nccc(C)c3NC(=O)CC#N)cc2)CCC1 10.1016/j.bmcl.2005.05.133
CHEMBL360260 129388 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity against Human bradykinin receptor B1Binding affinity against Human bradykinin receptor B1
ChEMBL 404 7 2 6 4.0 COC(=O)C1=C(c2ccc(CNc3nccc(C)c3NC(=O)CC#N)cc2)CCC1 10.1016/j.bmcl.2005.05.133
16221225 176147 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 589 9 3 5 5.9 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(Cl)cc1Cl)c1ccccc1 10.1021/jm070055c
CHEMBL442056 176147 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 589 9 3 5 5.9 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(Cl)cc1Cl)c1ccccc1 10.1021/jm070055c
44401768 132299 0 None - 1 Human 5.9 pKi = 5.9 Binding
Inhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cellsInhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cells
ChEMBL 418 8 2 6 3.6 COC(=O)c1ccccc1-c1ccc(CNc2ncccc2NC(=O)CN(C)C)cc1 10.1016/j.bmcl.2005.02.077
CHEMBL364670 132299 0 None - 1 Human 5.9 pKi = 5.9 Binding
Inhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cellsInhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cells
ChEMBL 418 8 2 6 3.6 COC(=O)c1ccccc1-c1ccc(CNc2ncccc2NC(=O)CN(C)C)cc1 10.1016/j.bmcl.2005.02.077
60142963 132707 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 533 6 2 8 3.8 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)c3ccnnc3)CC2)no1 nan
CHEMBL3648489 132707 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 533 6 2 8 3.8 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)c3ccnnc3)CC2)no1 nan
11293092 72034 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity against Human bradykinin receptor B1Binding affinity against Human bradykinin receptor B1
ChEMBL 421 7 2 7 3.4 COC(=O)c1ccccc1N1CCC(CNc2nccc(C)c2NC(=O)CC#N)CC1 10.1016/j.bmcl.2005.05.133
CHEMBL182785 72034 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity against Human bradykinin receptor B1Binding affinity against Human bradykinin receptor B1
ChEMBL 421 7 2 7 3.4 COC(=O)c1ccccc1N1CCC(CNc2nccc(C)c2NC(=O)CC#N)CC1 10.1016/j.bmcl.2005.05.133
16726096 162047 9 None -15 4 Rabbit 7.9 pKi = 7.9 Binding
Binding affinity to rabbit bradykinin B1 receptor expressed in CHO cellsBinding affinity to rabbit bradykinin B1 receptor expressed in CHO cells
ChEMBL 490 5 2 6 4.5 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)[C@@](C)(O)C(F)(F)F)c(F)c2)no1 10.1016/j.bmcl.2007.11.050
CHEMBL402831 162047 9 None -15 4 Rabbit 7.9 pKi = 7.9 Binding
Binding affinity to rabbit bradykinin B1 receptor expressed in CHO cellsBinding affinity to rabbit bradykinin B1 receptor expressed in CHO cells
ChEMBL 490 5 2 6 4.5 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)[C@@](C)(O)C(F)(F)F)c(F)c2)no1 10.1016/j.bmcl.2007.11.050
16221162 151101 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 611 9 2 5 6.7 CC1CCCC(C)N1Cc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 10.1021/jm070055c
CHEMBL390540 151101 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 611 9 2 5 6.7 CC1CCCC(C)N1Cc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 10.1021/jm070055c
11039234 67102 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Inhibition of human bradykinin B1 receptorInhibition of human bradykinin B1 receptor
ChEMBL 592 7 2 5 6.2 CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCC(N4CCCCC4)CC3)cc2)N=C(c2ccc(C)cc2)c2ccccc21 10.1021/jm034020y
CHEMBL1744085 67102 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Inhibition of human bradykinin B1 receptorInhibition of human bradykinin B1 receptor
ChEMBL 592 7 2 5 6.2 CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCC(N4CCCCC4)CC3)cc2)N=C(c2ccc(C)cc2)c2ccccc21 10.1021/jm034020y
16102882 148344 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 438 7 2 4 2.9 COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)C2(NC(=O)C(F)F)CC2)c(F)c1 10.1021/jm061094b
CHEMBL384893 148344 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 438 7 2 4 2.9 COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)C2(NC(=O)C(F)F)CC2)c(F)c1 10.1021/jm061094b
44392012 71655 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity against Human bradykinin receptor B1Binding affinity against Human bradykinin receptor B1
ChEMBL 419 7 2 7 3.3 COC(=O)c1ccccc1N1CC=C(CNc2nccc(C)c2NC(=O)CC#N)CC1 10.1016/j.bmcl.2005.05.133
CHEMBL182177 71655 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity against Human bradykinin receptor B1Binding affinity against Human bradykinin receptor B1
ChEMBL 419 7 2 7 3.3 COC(=O)c1ccccc1N1CC=C(CNc2nccc(C)c2NC(=O)CC#N)CC1 10.1016/j.bmcl.2005.05.133
44392544 133017 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity for Bradykinin receptor B1 expressed in HEK293 cellsBinding affinity for Bradykinin receptor B1 expressed in HEK293 cells
ChEMBL 635 19 2 7 4.5 CC(=O)c1cc(S(=O)(=O)NCCC(=O)N(CCCN(C)C)CCCN(C)C)ccc1NCC(c1ccccc1)c1ccccc1 10.1021/jm049747g
CHEMBL365009 133017 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity for Bradykinin receptor B1 expressed in HEK293 cellsBinding affinity for Bradykinin receptor B1 expressed in HEK293 cells
ChEMBL 635 19 2 7 4.5 CC(=O)c1cc(S(=O)(=O)NCCC(=O)N(CCCN(C)C)CCCN(C)C)ccc1NCC(c1ccccc1)c1ccccc1 10.1021/jm049747g
44570139 190816 0 None - 1 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]desArg from human B1 in human WI 38 cellsDisplacement of [3H]desArg from human B1 in human WI 38 cells
ChEMBL 474 11 2 5 2.7 O=C(O)CCNC(=O)CN(CCOc1ccccc1)S(=O)(=O)c1ccc(Cl)cc1Cl 10.1016/j.bmcl.2008.11.005
CHEMBL482173 190816 0 None - 1 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]desArg from human B1 in human WI 38 cellsDisplacement of [3H]desArg from human B1 in human WI 38 cells
ChEMBL 474 11 2 5 2.7 O=C(O)CCNC(=O)CN(CCOc1ccccc1)S(=O)(=O)c1ccc(Cl)cc1Cl 10.1016/j.bmcl.2008.11.005
16108968 172917 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cells
ChEMBL 541 10 2 4 5.6 O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)NCc1ccc(CN2CCCCC2)cc1 10.1021/jm061224g
CHEMBL426165 172917 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cells
ChEMBL 541 10 2 4 5.6 O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)NCc1ccc(CN2CCCCC2)cc1 10.1021/jm061224g
16221163 92346 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 555 9 3 5 5.3 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(Cl)cc1)c1ccccc1 10.1021/jm070055c
CHEMBL228030 92346 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 555 9 3 5 5.3 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(Cl)cc1)c1ccccc1 10.1021/jm070055c
44432176 94051 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 486 6 2 4 4.3 COC(=O)c1cc(Cl)ccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1016/j.bmcl.2007.04.040
CHEMBL233150 94051 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 486 6 2 4 4.3 COC(=O)c1cc(Cl)ccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1016/j.bmcl.2007.04.040
70683374 80624 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 640 7 1 5 6.8 O=C(CC1c2ccccc2CCN1S(=O)(=O)c1ccc(Cl)c(Cl)c1)Nc1ccc(N2CCC(N3CCCCC3)CC2)cc1 10.1016/j.bmcl.2012.03.065
CHEMBL2018864 80624 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 640 7 1 5 6.8 O=C(CC1c2ccccc2CCN1S(=O)(=O)c1ccc(Cl)c(Cl)c1)Nc1ccc(N2CCC(N3CCCCC3)CC2)cc1 10.1016/j.bmcl.2012.03.065
16220914 92344 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 529 9 3 5 4.6 CNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 10.1021/jm070055c
CHEMBL228014 92344 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 529 9 3 5 4.6 CNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 10.1021/jm070055c
11584184 179892 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells
ChEMBL 500 8 3 6 2.7 Cc1ccc(S(=O)(=O)C[C@@H](O)[C@@H](O)C(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2008.07.108
CHEMBL452057 179892 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells
ChEMBL 500 8 3 6 2.7 Cc1ccc(S(=O)(=O)C[C@@H](O)[C@@H](O)C(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2008.07.108
44430680 148854 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity at human bradykinin B1 receptorBinding affinity at human bradykinin B1 receptor
ChEMBL 416 6 2 4 5.0 N#CC1(c2ccccc2)CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1 10.1016/j.bmcl.2007.03.059
CHEMBL388029 148854 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity at human bradykinin B1 receptorBinding affinity at human bradykinin B1 receptor
ChEMBL 416 6 2 4 5.0 N#CC1(c2ccccc2)CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1 10.1016/j.bmcl.2007.03.059
16221056 92334 0 None 14 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 609 12 3 6 4.6 COCCNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1 10.1021/jm070055c
CHEMBL227870 92334 0 None 14 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 609 12 3 6 4.6 COCCNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1 10.1021/jm070055c
49863228 21992 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptorDisplacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptor
ChEMBL 639 10 2 4 6.8 O=C(C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1)N[C@@H]1CCCc2cc(C3(CN4CCCCC4)CC3)ccc21 10.1016/j.bmcl.2010.06.010
CHEMBL1210742 21992 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptorDisplacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptor
ChEMBL 639 10 2 4 6.8 O=C(C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1)N[C@@H]1CCCc2cc(C3(CN4CCCCC4)CC3)ccc21 10.1016/j.bmcl.2010.06.010
57382966 133985 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 555 7 2 9 3.2 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)C3(NC(=O)c4cccnn4)COC3)c(F)c2)no1 nan
CHEMBL3657636 133985 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 555 7 2 9 3.2 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)C3(NC(=O)c4cccnn4)COC3)c(F)c2)no1 nan
11422305 70533 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity for Bradykinin receptor B1 expressed in HEK293 cellsBinding affinity for Bradykinin receptor B1 expressed in HEK293 cells
ChEMBL 638 19 2 8 4.2 CN(C)CCCN(CCCN(C)C)C(=O)CCNS(=O)(=O)c1ccc(NCC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 10.1021/jm049747g
CHEMBL180143 70533 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity for Bradykinin receptor B1 expressed in HEK293 cellsBinding affinity for Bradykinin receptor B1 expressed in HEK293 cells
ChEMBL 638 19 2 8 4.2 CN(C)CCCN(CCCN(C)C)C(=O)CCNS(=O)(=O)c1ccc(NCC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 10.1021/jm049747g
70691811 80617 0 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 489 5 2 4 4.5 O=C(CC1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)Nc1ccccc1 10.1016/j.bmcl.2012.03.065
CHEMBL2018857 80617 0 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 489 5 2 4 4.5 O=C(CC1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)Nc1ccccc1 10.1016/j.bmcl.2012.03.065
10166801 109560 0 None - 1 Human 6.9 pKi = 6.9 Binding
Inhibition of human bradykinin B1 receptorInhibition of human bradykinin B1 receptor
ChEMBL 569 8 1 5 6.3 O=C(CCCN1C(=O)CN=C(C2CCCCC2)c2ccccc21)Nc1ccc(N2CCC(N3CCCCC3)CC2)cc1 10.1021/jm034020y
CHEMBL30525 109560 0 None - 1 Human 6.9 pKi = 6.9 Binding
Inhibition of human bradykinin B1 receptorInhibition of human bradykinin B1 receptor
ChEMBL 569 8 1 5 6.3 O=C(CCCN1C(=O)CN=C(C2CCCCC2)c2ccccc21)Nc1ccc(N2CCC(N3CCCCC3)CC2)cc1 10.1021/jm034020y
44392040 179659 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity against Human bradykinin receptor B1Binding affinity against Human bradykinin receptor B1
ChEMBL 444 7 2 6 4.3 COC(=O)C1C2C=CC(CC2)C1c1ccc(CNc2nccc(C)c2NC(=O)CC#N)cc1 10.1016/j.bmcl.2005.05.133
CHEMBL451549 179659 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity against Human bradykinin receptor B1Binding affinity against Human bradykinin receptor B1
ChEMBL 444 7 2 6 4.3 COC(=O)C1C2C=CC(CC2)C1c1ccc(CNc2nccc(C)c2NC(=O)CC#N)cc1 10.1016/j.bmcl.2005.05.133
57343016 84295 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 480 10 1 6 1.6 CN(Cc1ccc(C2=NCCN2)cc1)C(=O)COCCN(C)S(=O)(=O)c1c(F)cccc1F 10.1021/jm2016057
CHEMBL2087416 84295 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 480 10 1 6 1.6 CN(Cc1ccc(C2=NCCN2)cc1)C(=O)COCCN(C)S(=O)(=O)c1c(F)cccc1F 10.1021/jm2016057
16108963 168746 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cells
ChEMBL 583 9 2 5 5.9 O=C(C[C@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCOc2cc(CN3CCCCC3)ccc21 10.1021/jm061224g
CHEMBL415849 168746 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cells
ChEMBL 583 9 2 5 5.9 O=C(C[C@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCOc2cc(CN3CCCCC3)ccc21 10.1021/jm061224g
44430679 149331 0 None - 1 Human 5.8 pKi = 5.8 Binding
Binding affinity at human bradykinin B1 receptorBinding affinity at human bradykinin B1 receptor
ChEMBL 421 7 2 4 5.1 COC1(c2ccccc2)CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1 10.1016/j.bmcl.2007.03.059
CHEMBL389094 149331 0 None - 1 Human 5.8 pKi = 5.8 Binding
Binding affinity at human bradykinin B1 receptorBinding affinity at human bradykinin B1 receptor
ChEMBL 421 7 2 4 5.1 COC1(c2ccccc2)CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1 10.1016/j.bmcl.2007.03.059
60142025 132669 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 536 7 2 3 5.6 O=C(NC1(C(=O)NC2CCc3cc(-c4cc(Cl)cc(Cl)c4OCC(F)F)ccc32)CC1)C(F)(F)F nan
CHEMBL3648452 132669 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 536 7 2 3 5.6 O=C(NC1(C(=O)NC2CCc3cc(-c4cc(Cl)cc(Cl)c4OCC(F)F)ccc32)CC1)C(F)(F)F nan
44569938 195678 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]desArg from human B1 in human WI 38 cellsDisplacement of [3H]desArg from human B1 in human WI 38 cells
ChEMBL 629 14 1 7 4.7 COc1cc(CN(CC(=O)NCc2ccccc2Cl)S(=O)(=O)c2ccc(CN3CCOCC3)cc2)ccc1OCC(C)C 10.1016/j.bmcl.2008.11.005
CHEMBL507546 195678 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]desArg from human B1 in human WI 38 cellsDisplacement of [3H]desArg from human B1 in human WI 38 cells
ChEMBL 629 14 1 7 4.7 COc1cc(CN(CC(=O)NCc2ccccc2Cl)S(=O)(=O)c2ccc(CN3CCOCC3)cc2)ccc1OCC(C)C 10.1016/j.bmcl.2008.11.005
57399671 76344 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity to human B1 bradykinin receptorBinding affinity to human B1 bradykinin receptor
ChEMBL 506 5 1 4 6.6 Cc1cccc2occ(-c3ccc(C(=O)N[C@H]4CCCc5cc(CN6CCCCC6)ccc54)cc3)c(=O)c12 10.1016/j.bmcl.2011.10.068
CHEMBL1934265 76344 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity to human B1 bradykinin receptorBinding affinity to human B1 bradykinin receptor
ChEMBL 506 5 1 4 6.6 Cc1cccc2occ(-c3ccc(C(=O)N[C@H]4CCCc5cc(CN6CCCCC6)ccc54)cc3)c(=O)c12 10.1016/j.bmcl.2011.10.068
24895455 193203 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 479 8 3 5 4.0 O=C(NCC1CCCO1)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1 10.1021/jm800199h
CHEMBL487621 193203 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 479 8 3 5 4.0 O=C(NCC1CCCO1)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1 10.1021/jm800199h
12085130 84231 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 496 8 1 5 3.3 Cc1c(Cl)ccc(S(=O)(=O)N(C)CCC(=O)N(C)Cc2ccc(C3=NCCN3)cc2)c1Cl 10.1021/jm2016057
CHEMBL2087034 84231 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 496 8 1 5 3.3 Cc1c(Cl)ccc(S(=O)(=O)N(C)CCC(=O)N(C)Cc2ccc(C3=NCCN3)cc2)c1Cl 10.1021/jm2016057
60142835 132702 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 550 6 2 7 4.5 Cc1nc(-c2c(F)cc(Cl)cc2-c2cc(F)c3c(c2)CCC3NC(=O)C2(NC(=O)c3ccnnc3)CC2)no1 nan
CHEMBL3648484 132702 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 550 6 2 7 4.5 Cc1nc(-c2c(F)cc(Cl)cc2-c2cc(F)c3c(c2)CCC3NC(=O)C2(NC(=O)c3ccnnc3)CC2)no1 nan
23627520 80630 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 580 9 2 6 4.7 COc1ccc(S(=O)(=O)N2c3ccccc3-c3ccccc3C2CC(=O)NCCc2ccc(C3=NCCN3)cc2)cc1 10.1016/j.bmcl.2012.03.065
CHEMBL2018870 80630 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 580 9 2 6 4.7 COc1ccc(S(=O)(=O)N2c3ccccc3-c3ccccc3C2CC(=O)NCCc2ccc(C3=NCCN3)cc2)cc1 10.1016/j.bmcl.2012.03.065
16108965 168109 0 None 1000 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cells
ChEMBL 646 9 2 6 4.9 CN1c2cc(CN3CCCCC3)ccc2[C@H](NC(=O)C[C@@H](NS(=O)(=O)c2ccc3ccccc3c2)c2ccccc2)CS1(=O)=O 10.1021/jm061224g
CHEMBL412552 168109 0 None 1000 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cells
ChEMBL 646 9 2 6 4.9 CN1c2cc(CN3CCCCC3)ccc2[C@H](NC(=O)C[C@@H](NS(=O)(=O)c2ccc3ccccc3c2)c2ccccc2)CS1(=O)=O 10.1021/jm061224g
44561643 192427 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells
ChEMBL 542 8 3 6 3.7 CC(C)(C)c1ccc(S(=O)(=O)C[C@@H](O)[C@@H](O)C(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2008.07.108
CHEMBL486456 192427 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells
ChEMBL 542 8 3 6 3.7 CC(C)(C)c1ccc(S(=O)(=O)C[C@@H](O)[C@@H](O)C(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 10.1016/j.bmcl.2008.07.108
60143098 132710 0 None - 1 Human 5.8 pKi = 5.8 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 428 4 2 6 3.5 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)OCC3NC(=O)C2(N)CC2)no1 nan
CHEMBL3648492 132710 0 None - 1 Human 5.8 pKi = 5.8 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 428 4 2 6 3.5 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)OCC3NC(=O)C2(N)CC2)no1 nan
44570137 197756 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]desArg from human B1 in human WI 38 cellsDisplacement of [3H]desArg from human B1 in human WI 38 cells
ChEMBL 518 11 2 7 2.4 O=C(O)CCNC(=O)CN(CCOc1ccc2c(c1)OCO2)S(=O)(=O)c1ccc(Cl)cc1Cl 10.1016/j.bmcl.2008.11.005
CHEMBL518616 197756 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]desArg from human B1 in human WI 38 cellsDisplacement of [3H]desArg from human B1 in human WI 38 cells
ChEMBL 518 11 2 7 2.4 O=C(O)CCNC(=O)CN(CCOc1ccc2c(c1)OCO2)S(=O)(=O)c1ccc(Cl)cc1Cl 10.1016/j.bmcl.2008.11.005
11604201 80106 0 None - 1 Human 5.8 pKi = 5.8 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 422 7 2 4 3.2 COC(=O)c1ccccc1-c1ccc(CNC(=O)[C@@H](C)NC(=O)CC(F)(F)F)cc1 10.1021/jm0511280
CHEMBL201310 80106 0 None - 1 Human 5.8 pKi = 5.8 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 422 7 2 4 3.2 COC(=O)c1ccccc1-c1ccc(CNC(=O)[C@@H](C)NC(=O)CC(F)(F)F)cc1 10.1021/jm0511280
49863234 22001 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptorDisplacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptor
ChEMBL 611 12 3 4 6.3 C=C(CNCC1CC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2010.06.010
CHEMBL1210751 22001 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptorDisplacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptor
ChEMBL 611 12 3 4 6.3 C=C(CNCC1CC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2010.06.010
11526891 195657 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells
ChEMBL 554 8 3 6 3.7 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2008.07.108
CHEMBL507168 195657 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells
ChEMBL 554 8 3 6 3.7 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2008.07.108
57396212 76340 0 None - 1 Human 5.8 pKi = 5.8 Binding
Binding affinity to human B1 bradykinin receptorBinding affinity to human B1 bradykinin receptor
ChEMBL 526 5 1 4 6.9 O=C(N[C@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3ccc(Cl)cc3c2=O)cc1 10.1016/j.bmcl.2011.10.068
CHEMBL1934261 76340 0 None - 1 Human 5.8 pKi = 5.8 Binding
Binding affinity to human B1 bradykinin receptorBinding affinity to human B1 bradykinin receptor
ChEMBL 526 5 1 4 6.9 O=C(N[C@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3ccc(Cl)cc3c2=O)cc1 10.1016/j.bmcl.2011.10.068
11676747 94666 0 None - 1 Human 5.8 pKi = 5.8 Binding
Binding affinity at human bradykinin B1 receptorBinding affinity at human bradykinin B1 receptor
ChEMBL 449 7 2 5 4.7 COC(=O)C1(c2ccccc2)CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1 10.1016/j.bmcl.2007.03.059
CHEMBL233873 94666 0 None - 1 Human 5.8 pKi = 5.8 Binding
Binding affinity at human bradykinin B1 receptorBinding affinity at human bradykinin B1 receptor
ChEMBL 449 7 2 5 4.7 COC(=O)C1(c2ccccc2)CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1 10.1016/j.bmcl.2007.03.059
16102897 94014 17 None -1737 3 Rat 5.8 pKi = 5.8 Binding
Binding affinity to rat bradykinin B1 receptorBinding affinity to rat bradykinin B1 receptor
ChEMBL 486 6 2 4 4.3 COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1021/jm061094b
CHEMBL232943 94014 17 None -1737 3 Rat 5.8 pKi = 5.8 Binding
Binding affinity to rat bradykinin B1 receptorBinding affinity to rat bradykinin B1 receptor
ChEMBL 486 6 2 4 4.3 COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1021/jm061094b
70693872 80622 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 587 8 1 6 4.2 O=C(CC1CCc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)NCCN1CCN(c2ccncc2)CC1 10.1016/j.bmcl.2012.03.065
CHEMBL2018862 80622 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 587 8 1 6 4.2 O=C(CC1CCc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)NCCN1CCN(c2ccncc2)CC1 10.1016/j.bmcl.2012.03.065
11555599 180379 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells
ChEMBL 534 9 1 5 5.2 CO[C@H](CCS(=O)(=O)c1ccc2ccccc2c1)C(=O)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2008.07.108
CHEMBL453338 180379 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells
ChEMBL 534 9 1 5 5.2 CO[C@H](CCS(=O)(=O)c1ccc2ccccc2c1)C(=O)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2008.07.108
56835163 76343 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity to human B1 bradykinin receptorBinding affinity to human B1 bradykinin receptor
ChEMBL 510 5 1 4 6.4 O=C(N[C@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3cccc(F)c3c2=O)cc1 10.1016/j.bmcl.2011.10.068
CHEMBL1934264 76343 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity to human B1 bradykinin receptorBinding affinity to human B1 bradykinin receptor
ChEMBL 510 5 1 4 6.4 O=C(N[C@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3cccc(F)c3c2=O)cc1 10.1016/j.bmcl.2011.10.068
44411355 83579 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 508 6 1 6 3.7 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(C(C)=O)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
CHEMBL206935 83579 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 508 6 1 6 3.7 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(C(C)=O)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
11039234 67102 0 None -1 2 Rat 7.8 pKi = 7.8 Binding
Compound was tested for inhibition against rat Bradykinin receptor B1Compound was tested for inhibition against rat Bradykinin receptor B1
ChEMBL 592 7 2 5 6.2 CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCC(N4CCCCC4)CC3)cc2)N=C(c2ccc(C)cc2)c2ccccc21 10.1021/jm034020y
CHEMBL1744085 67102 0 None -1 2 Rat 7.8 pKi = 7.8 Binding
Compound was tested for inhibition against rat Bradykinin receptor B1Compound was tested for inhibition against rat Bradykinin receptor B1
ChEMBL 592 7 2 5 6.2 CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCC(N4CCCCC4)CC3)cc2)N=C(c2ccc(C)cc2)c2ccccc21 10.1021/jm034020y
16108966 91154 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cells
ChEMBL 555 10 2 4 6.1 C[C@@H](NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)c1ccc(CN2CCCCC2)cc1 10.1021/jm061224g
CHEMBL221925 91154 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cells
ChEMBL 555 10 2 4 6.1 C[C@@H](NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)c1ccc(CN2CCCCC2)cc1 10.1021/jm061224g
16108962 148498 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cells
ChEMBL 583 9 2 5 5.9 O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@H]1CCOc2cc(CN3CCCCC3)ccc21 10.1021/jm061224g
CHEMBL385740 148498 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cells
ChEMBL 583 9 2 5 5.9 O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@H]1CCOc2cc(CN3CCCCC3)ccc21 10.1021/jm061224g
60142836 132703 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 569 7 2 8 4.7 COc1cc(C(=O)NC2(C(=O)NC3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)cc(F)c43)CC2)on1 nan
CHEMBL3648485 132703 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 569 7 2 8 4.7 COc1cc(C(=O)NC2(C(=O)NC3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)cc(F)c43)CC2)on1 nan
11421944 92320 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 589 9 3 5 5.6 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1021/jm070055c
CHEMBL227778 92320 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 589 9 3 5 5.6 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1021/jm070055c
88925471 132683 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 538 5 2 7 3.5 Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)OCCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)n1 nan
CHEMBL3648465 132683 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 538 5 2 7 3.5 Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)OCCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)n1 nan
44430681 94773 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity at human bradykinin B1 receptorBinding affinity at human bradykinin B1 receptor
ChEMBL 434 6 2 4 5.2 N#CC1(c2ccccc2F)CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1 10.1016/j.bmcl.2007.03.059
CHEMBL234296 94773 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity at human bradykinin B1 receptorBinding affinity at human bradykinin B1 receptor
ChEMBL 434 6 2 4 5.2 N#CC1(c2ccccc2F)CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1 10.1016/j.bmcl.2007.03.059
11071992 67099 0 None -3 2 Rat 7.7 pKi = 7.7 Binding
Compound was tested for inhibition against rat Bradykinin receptor B1Compound was tested for inhibition against rat Bradykinin receptor B1
ChEMBL 584 7 2 5 6.4 CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCC(N4CCCCC4)CC3)cc2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm034020y
CHEMBL1744082 67099 0 None -3 2 Rat 7.7 pKi = 7.7 Binding
Compound was tested for inhibition against rat Bradykinin receptor B1Compound was tested for inhibition against rat Bradykinin receptor B1
ChEMBL 584 7 2 5 6.4 CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCC(N4CCCCC4)CC3)cc2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm034020y
60142834 132701 0 None - 1 Human 7.7 pKi = 7.7 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 580 7 2 8 4.5 COc1ncc(C(=O)NC2(C(=O)NC3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)cc(F)c43)CC2)cn1 nan
CHEMBL3648483 132701 0 None - 1 Human 7.7 pKi = 7.7 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 580 7 2 8 4.5 COc1ncc(C(=O)NC2(C(=O)NC3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)cc(F)c43)CC2)cn1 nan
57401425 76338 0 None - 1 Human 6.7 pKi = 6.7 Binding
Binding affinity to human B1 bradykinin receptorBinding affinity to human B1 bradykinin receptor
ChEMBL 492 5 1 4 6.3 O=C(N[C@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3ccccc3c2=O)cc1 10.1016/j.bmcl.2011.10.068
CHEMBL1934259 76338 0 None - 1 Human 6.7 pKi = 6.7 Binding
Binding affinity to human B1 bradykinin receptorBinding affinity to human B1 bradykinin receptor
ChEMBL 492 5 1 4 6.3 O=C(N[C@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3ccccc3c2=O)cc1 10.1016/j.bmcl.2011.10.068
44411050 83978 0 None - 1 Human 6.7 pKi = 6.7 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 453 7 1 6 4.3 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(CN3CCOCC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
CHEMBL207922 83978 0 None - 1 Human 6.7 pKi = 6.7 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 453 7 1 6 4.3 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(CN3CCOCC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
24895252 193075 0 None - 1 Human 7.7 pKi = 7.7 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 452 9 4 5 3.1 CNCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1 10.1021/jm800199h
CHEMBL1203967 193075 0 None - 1 Human 7.7 pKi = 7.7 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 452 9 4 5 3.1 CNCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1 10.1021/jm800199h
CHEMBL487444 193075 0 None - 1 Human 7.7 pKi = 7.7 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 452 9 4 5 3.1 CNCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1 10.1021/jm800199h
60143099 132711 0 None - 1 Human 7.7 pKi = 7.7 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 534 6 2 8 3.8 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)OCC3NC(=O)C2(NC(=O)c3ccnnc3)CC2)no1 nan
CHEMBL3648493 132711 0 None - 1 Human 7.7 pKi = 7.7 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 534 6 2 8 3.8 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)OCC3NC(=O)C2(NC(=O)c3ccnnc3)CC2)no1 nan
11519239 192539 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells
ChEMBL 520 8 2 5 4.5 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@@H](O)CCS(=O)(=O)c1ccc2ccccc2c1 10.1016/j.bmcl.2008.07.108
CHEMBL486640 192539 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells
ChEMBL 520 8 2 5 4.5 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@@H](O)CCS(=O)(=O)c1ccc2ccccc2c1 10.1016/j.bmcl.2008.07.108
57383009 133989 0 None - 1 Human 7.7 pKi = 7.7 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 558 8 2 4 5.1 C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)COC1)c1ccc(-c2cc(Cl)cc(Cl)c2OCC(F)F)cc1F nan
CHEMBL3657640 133989 0 None - 1 Human 7.7 pKi = 7.7 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 558 8 2 4 5.1 C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)COC1)c1ccc(-c2cc(Cl)cc(Cl)c2OCC(F)F)cc1F nan
16108964 148499 0 None - 1 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cells
ChEMBL 583 9 2 5 5.9 O=C(C[C@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@H]1CCOc2cc(CN3CCCCC3)ccc21 10.1021/jm061224g
CHEMBL385741 148499 0 None - 1 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cells
ChEMBL 583 9 2 5 5.9 O=C(C[C@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@H]1CCOc2cc(CN3CCCCC3)ccc21 10.1021/jm061224g
24970503 176556 0 None - 1 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]Lys-bradykinin from human recombinant bradykinin B1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]Lys-bradykinin from human recombinant bradykinin B1 receptor expressed in CHO cells by scintillation counting
ChEMBL 576 10 2 7 3.4 COc1cc2c(cc1OC)C(CC(=O)NCCc1ccc(C3=NCCN3)cc1)N(S(=O)(=O)c1ccc(C)cc1)CC2 10.1016/j.ejmech.2007.10.030
CHEMBL443900 176556 0 None - 1 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]Lys-bradykinin from human recombinant bradykinin B1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]Lys-bradykinin from human recombinant bradykinin B1 receptor expressed in CHO cells by scintillation counting
ChEMBL 576 10 2 7 3.4 COc1cc2c(cc1OC)C(CC(=O)NCCc1ccc(C3=NCCN3)cc1)N(S(=O)(=O)c1ccc(C)cc1)CC2 10.1016/j.ejmech.2007.10.030
44392068 71585 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity against Human bradykinin receptor B1Binding affinity against Human bradykinin receptor B1
ChEMBL 442 7 2 7 4.8 Cc1noc([C@H]2CC=CC[C@@H]2c2ccc(CNc3nccc(C)c3NC(=O)CC#N)cc2)n1 10.1016/j.bmcl.2005.05.133
CHEMBL181961 71585 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity against Human bradykinin receptor B1Binding affinity against Human bradykinin receptor B1
ChEMBL 442 7 2 7 4.8 Cc1noc([C@H]2CC=CC[C@@H]2c2ccc(CNc3nccc(C)c3NC(=O)CC#N)cc2)n1 10.1016/j.bmcl.2005.05.133
44430686 148856 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity at human bradykinin B1 receptorBinding affinity at human bradykinin B1 receptor
ChEMBL 452 6 2 4 5.3 N#CC1(c2cccc(F)c2F)CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1 10.1016/j.bmcl.2007.03.059
CHEMBL388031 148856 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity at human bradykinin B1 receptorBinding affinity at human bradykinin B1 receptor
ChEMBL 452 6 2 4 5.3 N#CC1(c2cccc(F)c2F)CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1 10.1016/j.bmcl.2007.03.059
16102897 94014 17 None 7 3 Human 8.7 pKi = 8.7 Binding
Binding affinity to rhesus monkey bradykinin B1 receptorBinding affinity to rhesus monkey bradykinin B1 receptor
ChEMBL 486 6 2 4 4.3 COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1021/jm061094b
CHEMBL232943 94014 17 None 7 3 Human 8.7 pKi = 8.7 Binding
Binding affinity to rhesus monkey bradykinin B1 receptorBinding affinity to rhesus monkey bradykinin B1 receptor
ChEMBL 486 6 2 4 4.3 COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1021/jm061094b
11259064 143904 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]des-arg10, leu9-kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-arg10, leu9-kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 433 6 2 5 5.4 C[C@@H](Nc1nccc(Cl)c1NC(=O)CC#N)c1ccc(-c2cccc(F)c2C#N)cc1 10.1021/jm049394l
CHEMBL374779 143904 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]des-arg10, leu9-kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-arg10, leu9-kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 433 6 2 5 5.4 C[C@@H](Nc1nccc(Cl)c1NC(=O)CC#N)c1ccc(-c2cccc(F)c2C#N)cc1 10.1021/jm049394l
10128103 152301 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 486 6 2 4 4.3 COC(=O)c1ccc(Cl)cc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1016/j.bmcl.2007.04.040
CHEMBL391491 152301 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 486 6 2 4 4.3 COC(=O)c1ccc(Cl)cc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1016/j.bmcl.2007.04.040
16041612 179747 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 499 8 2 7 4.0 O=C(Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccc(F)cn2)cc1)OCC1CCCO1 10.1021/jm800199h
CHEMBL451761 179747 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 499 8 2 7 4.0 O=C(Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccc(F)cn2)cc1)OCC1CCCO1 10.1021/jm800199h
24895454 193377 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 522 10 3 6 3.6 O=C(NCCCN1CCOCC1)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1 10.1021/jm800199h
CHEMBL487876 193377 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 522 10 3 6 3.6 O=C(NCCCN1CCOCC1)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1 10.1021/jm800199h
57342336 84232 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 526 10 1 6 2.9 Cc1c(Cl)ccc(S(=O)(=O)N(C)CCOCC(=O)N(C)Cc2ccc(C3=NCCN3)cc2)c1Cl 10.1021/jm2016057
CHEMBL2087035 84232 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 526 10 1 6 2.9 Cc1c(Cl)ccc(S(=O)(=O)N(C)CCOCC(=O)N(C)Cc2ccc(C3=NCCN3)cc2)c1Cl 10.1021/jm2016057
16726096 162047 9 None -2 4 Rat 8.7 pKi = 8.7 Binding
Binding affinity to rat bradykinin B1 receptor expressed in CHO cellsBinding affinity to rat bradykinin B1 receptor expressed in CHO cells
ChEMBL 490 5 2 6 4.5 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)[C@@](C)(O)C(F)(F)F)c(F)c2)no1 10.1016/j.bmcl.2007.11.050
CHEMBL402831 162047 9 None -2 4 Rat 8.7 pKi = 8.7 Binding
Binding affinity to rat bradykinin B1 receptor expressed in CHO cellsBinding affinity to rat bradykinin B1 receptor expressed in CHO cells
ChEMBL 490 5 2 6 4.5 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)[C@@](C)(O)C(F)(F)F)c(F)c2)no1 10.1016/j.bmcl.2007.11.050
57383010 133990 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 574 8 2 11 2.2 COc1cc(C(=O)NC2(C(=O)N[C@H](C)c3ncc(-c4cc(Cl)cc(F)c4-c4nnn(C)n4)cc3F)COC2)on1 nan
CHEMBL3657641 133990 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 574 8 2 11 2.2 COc1cc(C(=O)NC2(C(=O)N[C@H](C)c3ncc(-c4cc(Cl)cc(F)c4-c4nnn(C)n4)cc3F)COC2)on1 nan
44392156 71716 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity against Human bradykinin receptor B1Binding affinity against Human bradykinin receptor B1
ChEMBL 420 7 2 6 4.3 COC(=O)C1CCCCC1c1ccc(CNc2nccc(C)c2NC(=O)CC#N)cc1 10.1016/j.bmcl.2005.05.133
CHEMBL182275 71716 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity against Human bradykinin receptor B1Binding affinity against Human bradykinin receptor B1
ChEMBL 420 7 2 6 4.3 COC(=O)C1CCCCC1c1ccc(CNc2nccc(C)c2NC(=O)CC#N)cc1 10.1016/j.bmcl.2005.05.133
44411095 175597 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 508 7 1 6 4.6 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(C(C)C)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
CHEMBL437704 175597 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 508 7 1 6 4.6 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(C(C)C)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
70695989 80621 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 570 8 2 5 4.4 O=C(CC1c2ccccc2CCN1S(=O)(=O)c1ccc(Cl)c(Cl)c1)NCCc1ccc(C2=NCCN2)cc1 10.1016/j.bmcl.2012.03.065
CHEMBL2018861 80621 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 570 8 2 5 4.4 O=C(CC1c2ccccc2CCN1S(=O)(=O)c1ccc(Cl)c(Cl)c1)NCCc1ccc(C2=NCCN2)cc1 10.1016/j.bmcl.2012.03.065
57383008 133988 0 None - 1 Human 8.6 pKi = 8.6 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 557 9 2 6 4.8 C[C@@H](NC(=O)C1(NC(=O)c2ccno2)COC1)c1ccc(-c2cc(Cl)cc(Cl)c2OCC(F)F)cc1F nan
CHEMBL3657639 133988 0 None - 1 Human 8.6 pKi = 8.6 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 557 9 2 6 4.8 C[C@@H](NC(=O)C1(NC(=O)c2ccno2)COC1)c1ccc(-c2cc(Cl)cc(Cl)c2OCC(F)F)cc1F nan
44455492 101853 0 None - 1 Human 8.6 pKi = 8.6 Binding
Binding affinity to human bradykinin B1 receptor expressed in rat CNSBinding affinity to human bradykinin B1 receptor expressed in rat CNS
ChEMBL 520 7 2 3 6.0 CC(C)Oc1c(Cl)cc(Cl)cc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1016/j.bmcl.2007.11.057
CHEMBL255325 101853 0 None - 1 Human 8.6 pKi = 8.6 Binding
Binding affinity to human bradykinin B1 receptor expressed in rat CNSBinding affinity to human bradykinin B1 receptor expressed in rat CNS
ChEMBL 520 7 2 3 6.0 CC(C)Oc1c(Cl)cc(Cl)cc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1016/j.bmcl.2007.11.057
57382748 133960 0 None - 1 Human 8.6 pKi = 8.6 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 544 7 2 9 3.4 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)C3(NC(=O)c4ccno4)COC3)c(F)c2)no1 nan
CHEMBL3657611 133960 0 None - 1 Human 8.6 pKi = 8.6 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 544 7 2 9 3.4 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)C3(NC(=O)c4ccno4)COC3)c(F)c2)no1 nan
44432207 94012 0 None - 1 Human 8.6 pKi = 8.6 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 544 6 2 5 5.5 Cc1nc(-c2c(Cl)cc(Cl)cc2-c2ccc([C@@H](C)NC(=O)C3(NC(=O)C(F)(F)F)CC3)c(F)c2)no1 10.1016/j.bmcl.2007.04.040
CHEMBL232933 94012 0 None - 1 Human 8.6 pKi = 8.6 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 544 6 2 5 5.5 Cc1nc(-c2c(Cl)cc(Cl)cc2-c2ccc([C@@H](C)NC(=O)C3(NC(=O)C(F)(F)F)CC3)c(F)c2)no1 10.1016/j.bmcl.2007.04.040
57382749 133961 0 None - 1 Human 8.6 pKi = 8.6 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 558 7 2 9 3.7 Cc1cc(C(=O)NC2(C(=O)N[C@H](C)c3ncc(-c4cc(Cl)cc(F)c4-c4noc(C)n4)cc3F)COC2)on1 nan
CHEMBL3657612 133961 0 None - 1 Human 8.6 pKi = 8.6 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 558 7 2 9 3.7 Cc1cc(C(=O)NC2(C(=O)N[C@H](C)c3ncc(-c4cc(Cl)cc(F)c4-c4noc(C)n4)cc3F)COC2)on1 nan
16102884 89931 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 472 7 2 4 3.5 COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)C2(NC(=O)C(F)(F)Cl)CC2)c(F)c1 10.1021/jm061094b
CHEMBL218267 89931 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 472 7 2 4 3.5 COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)C2(NC(=O)C(F)(F)Cl)CC2)c(F)c1 10.1021/jm061094b
57523216 132694 0 None - 1 Human 8.6 pKi = 8.6 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 562 7 2 8 4.4 COc1ncc(C(=O)NC2(C(=O)N[C@H]3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)ccc43)CC2)cn1 nan
CHEMBL3648476 132694 0 None - 1 Human 8.6 pKi = 8.6 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 562 7 2 8 4.4 COc1ncc(C(=O)NC2(C(=O)N[C@H]3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)ccc43)CC2)cn1 nan
57382746 133958 0 None - 1 Human 8.6 pKi = 8.6 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 639 7 2 7 5.6 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)C3(NC(=O)c4cc(F)cc(C(F)(F)F)c4)COC3)c(F)c2)no1 nan
CHEMBL3657609 133958 0 None - 1 Human 8.6 pKi = 8.6 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 639 7 2 7 5.6 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)C3(NC(=O)c4cc(F)cc(C(F)(F)F)c4)COC3)c(F)c2)no1 nan
57382835 133968 0 None - 1 Human 8.6 pKi = 8.6 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 569 9 2 7 4.0 C[C@@H](NC(=O)C1(NC(=O)c2cncnc2)COC1)c1ncc(-c2cc(Cl)cc(Cl)c2OCC(F)F)cc1F nan
CHEMBL3657619 133968 0 None - 1 Human 8.6 pKi = 8.6 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 569 9 2 7 4.0 C[C@@H](NC(=O)C1(NC(=O)c2cncnc2)COC1)c1ncc(-c2cc(Cl)cc(Cl)c2OCC(F)F)cc1F nan
44432220 93976 0 None - 1 Human 8.6 pKi = 8.6 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 521 6 2 5 4.4 COC(=O)c1c(Cl)cc(Cl)cc1-c1cnc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1016/j.bmcl.2007.04.040
CHEMBL232750 93976 0 None - 1 Human 8.6 pKi = 8.6 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 521 6 2 5 4.4 COC(=O)c1c(Cl)cc(Cl)cc1-c1cnc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1016/j.bmcl.2007.04.040
24895550 180704 0 None - 1 Human 8.6 pKi = 8.6 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 481 8 2 7 3.8 O=C(Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccn2)cc1)OCC1CCCO1 10.1021/jm800199h
CHEMBL454086 180704 0 None - 1 Human 8.6 pKi = 8.6 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 481 8 2 7 3.8 O=C(Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccn2)cc1)OCC1CCCO1 10.1021/jm800199h
11456015 162156 0 None - 1 Human 8.6 pKi = 8.6 Binding
Binding affinity to human bradykinin B1 receptor expressed in rat CNSBinding affinity to human bradykinin B1 receptor expressed in rat CNS
ChEMBL 582 10 2 6 5.8 C[C@@H](NC(=O)C1(NC(=O)c2cc(C3CC3)on2)CC1)c1ncc(-c2cc(Cl)cc(Cl)c2OCC(F)F)cc1F 10.1016/j.bmcl.2007.11.057
CHEMBL403434 162156 0 None - 1 Human 8.6 pKi = 8.6 Binding
Binding affinity to human bradykinin B1 receptor expressed in rat CNSBinding affinity to human bradykinin B1 receptor expressed in rat CNS
ChEMBL 582 10 2 6 5.8 C[C@@H](NC(=O)C1(NC(=O)c2cc(C3CC3)on2)CC1)c1ncc(-c2cc(Cl)cc(Cl)c2OCC(F)F)cc1F 10.1016/j.bmcl.2007.11.057
44587041 194656 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration techniqueDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration technique
ChEMBL 574 6 3 6 4.0 NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2008.07.055
CHEMBL496459 194656 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration techniqueDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration technique
ChEMBL 574 6 3 6 4.0 NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2008.07.055
71454502 85787 0 None - 1 Human 8.6 pKi = 8.6 Binding
Inhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cellsInhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cells
ChEMBL 428 7 2 6 4.9 COC(=O)c1ccccc1-c1ccc([C@@H](C)Nc2nccc(C)c2NC(=O)CC#N)cc1 10.1016/j.bmcl.2005.02.077
CHEMBL2113091 85787 0 None - 1 Human 8.6 pKi = 8.6 Binding
Inhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cellsInhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cells
ChEMBL 428 7 2 6 4.9 COC(=O)c1ccccc1-c1ccc([C@@H](C)Nc2nccc(C)c2NC(=O)CC#N)cc1 10.1016/j.bmcl.2005.02.077
11363856 91310 0 None -5 3 Rabbit 8.6 pKi = 8.6 Binding
Binding affinity to rabbit bradykinin B1 receptorBinding affinity to rabbit bradykinin B1 receptor
ChEMBL 490 7 2 7 5.9 Cc1noc(-c2c(F)cccc2-c2ccc([C@@H](C)Nc3nccc(Cl)c3NC(=O)CC#N)cc2)n1 10.1021/jm049394l
CHEMBL222038 91310 0 None -5 3 Rabbit 8.6 pKi = 8.6 Binding
Binding affinity to rabbit bradykinin B1 receptorBinding affinity to rabbit bradykinin B1 receptor
ChEMBL 490 7 2 7 5.9 Cc1noc(-c2c(F)cccc2-c2ccc([C@@H](C)Nc3nccc(Cl)c3NC(=O)CC#N)cc2)n1 10.1021/jm049394l
44411442 147214 0 None - 1 Human 8.6 pKi = 8.6 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 548 7 1 6 5.5 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(C4CCCCC4)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
CHEMBL380920 147214 0 None - 1 Human 8.6 pKi = 8.6 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 548 7 1 6 5.5 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(C4CCCCC4)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
16102885 89984 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 454 7 2 4 3.2 COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)C2(NC(=O)C(F)Cl)CC2)c(F)c1 10.1021/jm061094b
CHEMBL218552 89984 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 454 7 2 4 3.2 COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)C2(NC(=O)C(F)Cl)CC2)c(F)c1 10.1021/jm061094b
57342845 84288 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 512 10 1 6 2.4 CN(Cc1ccc(C2=NCCN2)cc1)C(=O)COCCN(C)S(=O)(=O)c1ccccc1C(F)(F)F 10.1021/jm2016057
CHEMBL2087409 84288 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 512 10 1 6 2.4 CN(Cc1ccc(C2=NCCN2)cc1)C(=O)COCCN(C)S(=O)(=O)c1ccccc1C(F)(F)F 10.1021/jm2016057
44411353 82340 0 None - 1 Human 8.5 pKi = 8.5 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 520 7 1 6 4.7 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(C4CCC4)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
CHEMBL204562 82340 0 None - 1 Human 8.5 pKi = 8.5 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 520 7 1 6 4.7 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(C4CCC4)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
70691814 80628 0 None - 1 Human 8.5 pKi = 8.5 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 592 8 2 5 5.6 Cc1cc(C)c(S(=O)(=O)N2c3ccccc3-c3ccccc3C2CC(=O)NCCc2ccc(C3=NCCN3)cc2)cc1C 10.1016/j.bmcl.2012.03.065
CHEMBL2018868 80628 0 None - 1 Human 8.5 pKi = 8.5 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 592 8 2 5 5.6 Cc1cc(C)c(S(=O)(=O)N2c3ccccc3-c3ccccc3C2CC(=O)NCCc2ccc(C3=NCCN3)cc2)cc1C 10.1016/j.bmcl.2012.03.065
16102881 90132 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 506 7 2 4 3.9 COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)C2(NC(=O)C(F)(F)C(F)(F)F)CC2)c(F)c1 10.1021/jm061094b
CHEMBL219309 90132 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 506 7 2 4 3.9 COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)C2(NC(=O)C(F)(F)C(F)(F)F)CC2)c(F)c1 10.1021/jm061094b
60142027 132671 0 None - 1 Human 7.7 pKi = 7.7 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 522 5 2 5 4.8 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 nan
CHEMBL3648454 132671 0 None - 1 Human 7.7 pKi = 7.7 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 522 5 2 5 4.8 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 nan
16221054 148850 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 591 9 3 5 5.6 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cc(Cl)c(F)cc1F)c1ccccc1 10.1021/jm070055c
CHEMBL387982 148850 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 591 9 3 5 5.6 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cc(Cl)c(F)cc1F)c1ccccc1 10.1021/jm070055c
11452874 159168 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]DAKA from human bradykinin B1 receptor in IL1-beta stimulated IMR90 cellsDisplacement of [3H]DAKA from human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells
ChEMBL 418 4 3 3 4.3 O=C(Nc1[nH]nc(C(=O)Nc2ccccc2)c1Br)c1ccccc1Cl 10.1021/jm051292n
CHEMBL397037 159168 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]DAKA from human bradykinin B1 receptor in IL1-beta stimulated IMR90 cellsDisplacement of [3H]DAKA from human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells
ChEMBL 418 4 3 3 4.3 O=C(Nc1[nH]nc(C(=O)Nc2ccccc2)c1Br)c1ccccc1Cl 10.1021/jm051292n
44402075 78784 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]des-arg10, leu9-kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-arg10, leu9-kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 417 9 2 5 5.3 CCCCC(=O)Nc1cccnc1NCc1ccc(-c2ccccc2C(=O)OC)cc1 10.1021/jm049394l
CHEMBL197462 78784 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]des-arg10, leu9-kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-arg10, leu9-kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 417 9 2 5 5.3 CCCCC(=O)Nc1cccnc1NCc1ccc(-c2ccccc2C(=O)OC)cc1 10.1021/jm049394l
44402075 78784 0 None - 1 Human 6.7 pKi = 6.7 Binding
Inhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cellsInhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cells
ChEMBL 417 9 2 5 5.3 CCCCC(=O)Nc1cccnc1NCc1ccc(-c2ccccc2C(=O)OC)cc1 10.1016/j.bmcl.2005.02.077
CHEMBL197462 78784 0 None - 1 Human 6.7 pKi = 6.7 Binding
Inhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cellsInhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cells
ChEMBL 417 9 2 5 5.3 CCCCC(=O)Nc1cccnc1NCc1ccc(-c2ccccc2C(=O)OC)cc1 10.1016/j.bmcl.2005.02.077
24895354 185669 3 None - 1 Human 6.7 pKi = 6.7 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 395 6 2 5 3.1 CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccn2)cc1 10.1021/jm800199h
CHEMBL469875 185669 3 None - 1 Human 6.7 pKi = 6.7 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 395 6 2 5 3.1 CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccn2)cc1 10.1021/jm800199h
16726096 162047 9 None -239 4 Dog 6.7 pKi = 6.7 Binding
Binding affinity to dog bradykinin B1 receptor expressed in CHO cellsBinding affinity to dog bradykinin B1 receptor expressed in CHO cells
ChEMBL 490 5 2 6 4.5 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)[C@@](C)(O)C(F)(F)F)c(F)c2)no1 10.1016/j.bmcl.2007.11.050
CHEMBL402831 162047 9 None -239 4 Dog 6.7 pKi = 6.7 Binding
Binding affinity to dog bradykinin B1 receptor expressed in CHO cellsBinding affinity to dog bradykinin B1 receptor expressed in CHO cells
ChEMBL 490 5 2 6 4.5 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)[C@@](C)(O)C(F)(F)F)c(F)c2)no1 10.1016/j.bmcl.2007.11.050
49863232 21999 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptorDisplacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptor
ChEMBL 601 12 4 5 4.9 C=C(CNCCO)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2010.06.010
CHEMBL1210749 21999 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptorDisplacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptor
ChEMBL 601 12 4 5 4.9 C=C(CNCCO)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2010.06.010
44569935 176271 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]desArg from human B1 in human WI 38 cellsDisplacement of [3H]desArg from human B1 in human WI 38 cells
ChEMBL 646 13 1 6 5.3 CC(C)COc1ccc(CN(CC(=O)NCc2ccccc2Cl)S(=O)(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Cl 10.1016/j.bmcl.2008.11.005
CHEMBL443207 176271 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]desArg from human B1 in human WI 38 cellsDisplacement of [3H]desArg from human B1 in human WI 38 cells
ChEMBL 646 13 1 6 5.3 CC(C)COc1ccc(CN(CC(=O)NCc2ccccc2Cl)S(=O)(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Cl 10.1016/j.bmcl.2008.11.005
16221160 104045 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 597 10 3 5 6.3 O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCOc2cc(CNC3CCCCC3)ccc21 10.1021/jm070055c
CHEMBL268911 104045 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 597 10 3 5 6.3 O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCOc2cc(CNC3CCCCC3)ccc21 10.1021/jm070055c
44569939 185509 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]desArg from human B1 in human WI 38 cellsDisplacement of [3H]desArg from human B1 in human WI 38 cells
ChEMBL 580 12 1 7 4.2 COc1ccccc1CCNC(=O)CN(CCOc1ccc2c(c1)OCO2)S(=O)(=O)c1ccc(Cl)cc1Cl 10.1016/j.bmcl.2008.11.005
CHEMBL468492 185509 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]desArg from human B1 in human WI 38 cellsDisplacement of [3H]desArg from human B1 in human WI 38 cells
ChEMBL 580 12 1 7 4.2 COc1ccccc1CCNC(=O)CN(CCOc1ccc2c(c1)OCO2)S(=O)(=O)c1ccc(Cl)cc1Cl 10.1016/j.bmcl.2008.11.005
60141184 132719 0 None - 1 Human 6.7 pKi = 6.7 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 427 4 2 7 2.3 Cn1nnc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(N)CC2)n1 nan
CHEMBL3648501 132719 0 None - 1 Human 6.7 pKi = 6.7 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 427 4 2 7 2.3 Cn1nnc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(N)CC2)n1 nan
44410972 84053 0 None - 1 Human 5.7 pKi = 5.7 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 467 6 1 6 3.9 COC(=O)c1c(F)cccc1-c1ccc(CNc2cc(C(=O)N3CCOCC3)ccn2)c(F)c1 10.1016/j.bmcl.2006.01.112
CHEMBL208086 84053 0 None - 1 Human 5.7 pKi = 5.7 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 467 6 1 6 3.9 COC(=O)c1c(F)cccc1-c1ccc(CNc2cc(C(=O)N3CCOCC3)ccn2)c(F)c1 10.1016/j.bmcl.2006.01.112
60142305 132682 0 None - 1 Human 6.7 pKi = 6.7 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 538 5 2 6 4.7 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)OCCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 nan
CHEMBL3648464 132682 0 None - 1 Human 6.7 pKi = 6.7 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 538 5 2 6 4.7 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)OCCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 nan
44411349 147142 0 None - 1 Human 6.7 pKi = 6.7 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 550 6 1 6 4.8 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(C(=O)C(C)(C)C)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
CHEMBL380834 147142 0 None - 1 Human 6.7 pKi = 6.7 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 550 6 1 6 4.8 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(C(=O)C(C)(C)C)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
24895450 198170 0 None - 1 Human 6.7 pKi = 6.7 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 423 6 2 4 3.8 CN(C)C(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1 10.1021/jm800199h
CHEMBL519247 198170 0 None - 1 Human 6.7 pKi = 6.7 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 423 6 2 4 3.8 CN(C)C(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1 10.1021/jm800199h
24895186 192956 0 None - 1 Human 6.7 pKi = 6.7 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 409 6 3 4 3.5 CNC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1 10.1021/jm800199h
CHEMBL487263 192956 0 None - 1 Human 6.7 pKi = 6.7 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 409 6 3 4 3.5 CNC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1 10.1021/jm800199h
60142024 132668 0 None - 1 Human 5.7 pKi = 5.7 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 446 5 2 4 3.5 COC(=O)c1ccccc1-c1ccc2c(c1)CCC2NC(=O)C1(NC(=O)C(F)(F)F)CC1 nan
CHEMBL3648451 132668 0 None - 1 Human 5.7 pKi = 5.7 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 446 5 2 4 3.5 COC(=O)c1ccccc1-c1ccc2c(c1)CCC2NC(=O)C1(NC(=O)C(F)(F)F)CC1 nan
10311064 84759 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 484 7 2 4 4.2 COC(=O)c1c(F)cccc1-c1ccc([C@H](C)NC(=O)C2(NC(=O)CC(F)(F)F)CC2)c(F)c1 10.1021/jm061094b
CHEMBL2096845 84759 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 484 7 2 4 4.2 COC(=O)c1c(F)cccc1-c1ccc([C@H](C)NC(=O)C2(NC(=O)CC(F)(F)F)CC2)c(F)c1 10.1021/jm061094b
44570138 190384 0 None - 1 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]desArg from human B1 in human WI 38 cellsDisplacement of [3H]desArg from human B1 in human WI 38 cells
ChEMBL 456 8 1 4 3.3 CNC(=O)CN(CCOc1ccc2c(c1)CCC2)S(=O)(=O)c1ccc(Cl)cc1Cl 10.1016/j.bmcl.2008.11.005
CHEMBL480204 190384 0 None - 1 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]desArg from human B1 in human WI 38 cellsDisplacement of [3H]desArg from human B1 in human WI 38 cells
ChEMBL 456 8 1 4 3.3 CNC(=O)CN(CCOc1ccc2c(c1)CCC2)S(=O)(=O)c1ccc(Cl)cc1Cl 10.1016/j.bmcl.2008.11.005
44411360 83657 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 544 7 1 7 3.1 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(S(C)(=O)=O)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
CHEMBL206982 83657 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 544 7 1 7 3.1 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(S(C)(=O)=O)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
24895351 196637 3 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 412 6 2 4 3.8 CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccc(F)cc2)cc1 10.1021/jm800199h
CHEMBL516783 196637 3 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 412 6 2 4 3.8 CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccc(F)cc2)cc1 10.1021/jm800199h
11284458 147366 2 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration techniqueDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration technique
ChEMBL 565 7 2 4 5.7 CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2008.07.055
CHEMBL381366 147366 2 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration techniqueDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration technique
ChEMBL 565 7 2 4 5.7 CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2008.07.055
11670860 192541 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells
ChEMBL 520 8 2 5 4.5 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)CCS(=O)(=O)c1ccc2ccccc2c1 10.1016/j.bmcl.2008.07.108
CHEMBL486641 192541 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells
ChEMBL 520 8 2 5 4.5 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)CCS(=O)(=O)c1ccc2ccccc2c1 10.1016/j.bmcl.2008.07.108
60141039 132713 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 553 7 2 9 4.0 COc1cc(C(=O)NC2(C(=O)NC3COc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)ccc43)CC2)on1 nan
CHEMBL3648495 132713 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 553 7 2 9 4.0 COc1cc(C(=O)NC2(C(=O)NC3COc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)ccc43)CC2)on1 nan
11376509 71090 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity for Bradykinin receptor B1 expressed in HEK293 cellsBinding affinity for Bradykinin receptor B1 expressed in HEK293 cells
ChEMBL 567 16 1 7 4.7 CN(C)CCCN(CCCN(C)C)S(=O)(=O)c1ccc(NCC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 10.1021/jm049747g
CHEMBL181098 71090 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity for Bradykinin receptor B1 expressed in HEK293 cellsBinding affinity for Bradykinin receptor B1 expressed in HEK293 cells
ChEMBL 567 16 1 7 4.7 CN(C)CCCN(CCCN(C)C)S(=O)(=O)c1ccc(NCC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 10.1021/jm049747g
44401703 140256 0 None - 1 Human 6.6 pKi = 6.6 Binding
Inhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cellsInhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cells
ChEMBL 403 7 2 5 4.7 COC(=O)c1ccccc1-c1ccc(CNc2ncccc2NC(=O)C(C)C)cc1 10.1016/j.bmcl.2005.02.077
CHEMBL370704 140256 0 None - 1 Human 6.6 pKi = 6.6 Binding
Inhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cellsInhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cells
ChEMBL 403 7 2 5 4.7 COC(=O)c1ccccc1-c1ccc(CNc2ncccc2NC(=O)C(C)C)cc1 10.1016/j.bmcl.2005.02.077
70695304 84225 0 None -17 2 Human 5.6 pKi = 5.6 Binding
Binding affinity to B1 receptorBinding affinity to B1 receptor
ChEMBL 556 8 2 6 4.0 Cc1ccc2cccc(OCc3cc(S(=O)(=O)N4CCC[C@H]4C(=O)NCC4CCNCC4)ccc3Cl)c2n1 10.1021/jm2016057
CHEMBL2087027 84225 0 None -17 2 Human 5.6 pKi = 5.6 Binding
Binding affinity to B1 receptorBinding affinity to B1 receptor
ChEMBL 556 8 2 6 4.0 Cc1ccc2cccc(OCc3cc(S(=O)(=O)N4CCC[C@H]4C(=O)NCC4CCNCC4)ccc3Cl)c2n1 10.1021/jm2016057
70688994 84226 0 None 18 2 Human 5.6 pKi = 5.6 Binding
Binding affinity to B1 receptorBinding affinity to B1 receptor
ChEMBL 433 5 2 4 2.6 Cc1c(Cl)ccc(S(=O)(=O)N2CCC[C@H]2C(=O)NCC2CCNCC2)c1Cl 10.1021/jm2016057
CHEMBL2087028 84226 0 None 18 2 Human 5.6 pKi = 5.6 Binding
Binding affinity to B1 receptorBinding affinity to B1 receptor
ChEMBL 433 5 2 4 2.6 Cc1c(Cl)ccc(S(=O)(=O)N2CCC[C@H]2C(=O)NCC2CCNCC2)c1Cl 10.1021/jm2016057
60142168 132676 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 550 7 2 3 6.0 O=C(NC1(C(=O)NC2CCCc3cc(-c4cc(Cl)cc(Cl)c4OCC(F)F)ccc32)CC1)C(F)(F)F nan
CHEMBL3648459 132676 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 550 7 2 3 6.0 O=C(NC1(C(=O)NC2CCCc3cc(-c4cc(Cl)cc(Cl)c4OCC(F)F)ccc32)CC1)C(F)(F)F nan
CHEMBL2369828 216474 0 None - 1 Human 7.6 pKi = 7.6 Binding
Ability to bind to human cloned B1 receptor in competition binding experiments with [3H][des-Arg10,Leu9]-Kallidin.Ability to bind to human cloned B1 receptor in competition binding experiments with [3H][des-Arg10,Leu9]-Kallidin.
ChEMBL None None None NC(N)=NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1c2ccccc2C[C@H]1C(=O)O 10.1021/jm990961s
60142439 132688 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 524 5 2 7 3.1 Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)OCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)n1 nan
CHEMBL3648470 132688 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 524 5 2 7 3.1 Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)OCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)n1 nan
24895256 193201 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 453 9 3 5 3.5 COCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1 10.1021/jm800199h
CHEMBL487620 193201 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 453 9 3 5 3.5 COCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1 10.1021/jm800199h
24895184 201357 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 413 6 2 5 3.2 CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccc(F)cn2)cc1 10.1021/jm800199h
CHEMBL530549 201357 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 413 6 2 5 3.2 CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccc(F)cn2)cc1 10.1021/jm800199h
9919335 113362 1 None 489 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards human cloned B1 receptor was determined using [3H][des-Arg10-Leu9]-kallidin as radioligandBinding affinity towards human cloned B1 receptor was determined using [3H][des-Arg10-Leu9]-kallidin as radioligand
ChEMBL 922 22 9 13 -2.1 NCCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC2(CC1)C(=O)N(CC(=O)N[C@@H](CO)C(=O)N[C@@H]1CSc3ccccc3N(CC(=O)O)C1=O)CN2CCc1ccccc1 10.1021/jm990962k
CHEMBL3142392 113362 1 None 489 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards human cloned B1 receptor was determined using [3H][des-Arg10-Leu9]-kallidin as radioligandBinding affinity towards human cloned B1 receptor was determined using [3H][des-Arg10-Leu9]-kallidin as radioligand
ChEMBL 922 22 9 13 -2.1 NCCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC2(CC1)C(=O)N(CC(=O)N[C@@H](CO)C(=O)N[C@@H]1CSc3ccccc3N(CC(=O)O)C1=O)CN2CCc1ccccc1 10.1021/jm990962k
44430684 94819 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity at human bradykinin B1 receptorBinding affinity at human bradykinin B1 receptor
ChEMBL 484 6 2 4 6.1 N#CC1(c2cccc(C(F)(F)F)c2)CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1 10.1016/j.bmcl.2007.03.059
CHEMBL234512 94819 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity at human bradykinin B1 receptorBinding affinity at human bradykinin B1 receptor
ChEMBL 484 6 2 4 6.1 N#CC1(c2cccc(C(F)(F)F)c2)CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1 10.1016/j.bmcl.2007.03.059
44455108 161923 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 417 5 2 4 3.3 COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)[C@@](C)(O)C(F)(F)F)c(F)c1 10.1016/j.bmcl.2007.11.050
CHEMBL402114 161923 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 417 5 2 4 3.3 COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)[C@@](C)(O)C(F)(F)F)c(F)c1 10.1016/j.bmcl.2007.11.050
16221164 168525 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 577 9 3 5 5.9 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(C(C)(C)C)cc1)c1ccccc1 10.1021/jm070055c
CHEMBL413786 168525 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 577 9 3 5 5.9 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(C(C)(C)C)cc1)c1ccccc1 10.1021/jm070055c
57382878 133974 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 521 8 2 8 2.7 COCC(=O)NC1(C(=O)N[C@H](C)c2ncc(-c3cc(Cl)cc(F)c3-c3noc(C)n3)cc2F)COC1 nan
CHEMBL3657625 133974 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 521 8 2 8 2.7 COCC(=O)NC1(C(=O)N[C@H](C)c2ncc(-c3cc(Cl)cc(F)c3-c3noc(C)n3)cc2F)COC1 nan
44392045 138561 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity against Human bradykinin receptor B1Binding affinity against Human bradykinin receptor B1
ChEMBL 418 7 2 6 4.3 COC(=O)c1ccccc1C1=CCC(CNc2nccc(C)c2NC(=O)CC#N)CC1 10.1016/j.bmcl.2005.05.133
CHEMBL369307 138561 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity against Human bradykinin receptor B1Binding affinity against Human bradykinin receptor B1
ChEMBL 418 7 2 6 4.3 COC(=O)c1ccccc1C1=CCC(CNc2nccc(C)c2NC(=O)CC#N)CC1 10.1016/j.bmcl.2005.05.133
44411347 83663 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 504 7 1 6 3.8 C#CCN1CCN(C(=O)c2ccc(NCc3ccc(-c4cccc(F)c4C(=O)OC)cc3F)nc2)CC1 10.1016/j.bmcl.2006.01.112
CHEMBL207000 83663 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 504 7 1 6 3.8 C#CCN1CCN(C(=O)c2ccc(NCc3ccc(-c4cccc(F)c4C(=O)OC)cc3F)nc2)CC1 10.1016/j.bmcl.2006.01.112
16221053 149127 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 573 9 3 5 5.4 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(F)c(Cl)c1)c1ccccc1 10.1021/jm070055c
CHEMBL388720 149127 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 573 9 3 5 5.4 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(F)c(Cl)c1)c1ccccc1 10.1021/jm070055c
11575578 80712 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 430 7 2 6 2.5 COC(=O)c1ccccc1-c1ccc(CNC(=O)C2(NC(=O)c3cncnc3)CC2)cc1 10.1021/jm0511280
CHEMBL202090 80712 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 430 7 2 6 2.5 COC(=O)c1ccccc1-c1ccc(CNC(=O)C2(NC(=O)c3cncnc3)CC2)cc1 10.1021/jm0511280
60141181 132716 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 551 6 2 8 4.1 Cc1cc(C(=O)NC2(C(=O)N[C@H]3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)ccc43)COC2)on1 nan
CHEMBL3648498 132716 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 551 6 2 8 4.1 Cc1cc(C(=O)NC2(C(=O)N[C@H]3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)ccc43)COC2)on1 nan
44391977 129551 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity against Human bradykinin receptor B1Binding affinity against Human bradykinin receptor B1
ChEMBL 403 7 2 7 3.4 COC(=O)c1cccn1-c1ccc(CNc2nccc(C)c2NC(=O)CC#N)cc1 10.1016/j.bmcl.2005.05.133
CHEMBL360500 129551 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity against Human bradykinin receptor B1Binding affinity against Human bradykinin receptor B1
ChEMBL 403 7 2 7 3.4 COC(=O)c1cccn1-c1ccc(CNc2nccc(C)c2NC(=O)CC#N)cc1 10.1016/j.bmcl.2005.05.133
11180748 175121 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity for Bradykinin receptor B1 expressed in HEK293 cellsBinding affinity for Bradykinin receptor B1 expressed in HEK293 cells
ChEMBL 581 17 1 7 4.8 CN(C)CCCN(CCCN(C)C)S(=O)(=O)c1ccc(NC(Cc2ccccc2)Cc2ccccc2)c([N+](=O)[O-])c1 10.1021/jm049747g
CHEMBL434341 175121 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity for Bradykinin receptor B1 expressed in HEK293 cellsBinding affinity for Bradykinin receptor B1 expressed in HEK293 cells
ChEMBL 581 17 1 7 4.8 CN(C)CCCN(CCCN(C)C)S(=O)(=O)c1ccc(NC(Cc2ccccc2)Cc2ccccc2)c([N+](=O)[O-])c1 10.1021/jm049747g
24895111 183499 3 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 412 6 2 4 3.8 CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2F)cc1 10.1021/jm800199h
CHEMBL460045 183499 3 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 412 6 2 4 3.8 CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2F)cc1 10.1021/jm800199h
44411080 173005 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 556 8 1 6 5.4 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(Cc4ccccc4)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
CHEMBL426681 173005 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 556 8 1 6 5.4 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(Cc4ccccc4)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
60141326 132724 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 444 4 2 7 3.1 Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)SCC3NC(=O)C2(N)CC2)n1 nan
CHEMBL3648506 132724 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 444 4 2 7 3.1 Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)SCC3NC(=O)C2(N)CC2)n1 nan
16220987 85887 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 555 9 3 5 5.3 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(Cl)c1)c1ccccc1 10.1021/jm070055c
CHEMBL2113274 85887 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 555 9 3 5 5.3 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(Cl)c1)c1ccccc1 10.1021/jm070055c
44411071 83656 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 530 8 1 6 4.4 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(CC(F)F)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
CHEMBL206975 83656 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 530 8 1 6 4.4 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(CC(F)F)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
24895182 185643 3 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 430 6 2 4 4.0 CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2cccc(F)c2F)cc1 10.1021/jm800199h
CHEMBL469675 185643 3 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 430 6 2 4 4.0 CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2cccc(F)c2F)cc1 10.1021/jm800199h
10187347 200139 0 None - 1 Human 7.6 pKi = 7.6 Binding
Inhibition of human bradykinin B1 receptorInhibition of human bradykinin B1 receptor
ChEMBL 544 7 2 5 5.5 CCCN1C(=O)C(NC(=O)Nc2ccc(N3CCC(N(C)C)CC3)cc2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm034020y
CHEMBL52498 200139 0 None - 1 Human 7.6 pKi = 7.6 Binding
Inhibition of human bradykinin B1 receptorInhibition of human bradykinin B1 receptor
ChEMBL 544 7 2 5 5.5 CCCN1C(=O)C(NC(=O)Nc2ccc(N3CCC(N(C)C)CC3)cc2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm034020y
44411252 83665 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity to human BK1 receptor E273 mutantBinding affinity to human BK1 receptor E273 mutant
ChEMBL 543 7 1 7 4.8 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(c4ccccn4)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
CHEMBL207011 83665 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity to human BK1 receptor E273 mutantBinding affinity to human BK1 receptor E273 mutant
ChEMBL 543 7 1 7 4.8 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(c4ccccn4)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
57390932 76333 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity to human B1 bradykinin receptorBinding affinity to human B1 bradykinin receptor
ChEMBL 526 5 1 4 6.9 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3cccc(Cl)c3c2=O)c1 10.1016/j.bmcl.2011.10.068
CHEMBL1934254 76333 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity to human B1 bradykinin receptorBinding affinity to human B1 bradykinin receptor
ChEMBL 526 5 1 4 6.9 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3cccc(Cl)c3c2=O)c1 10.1016/j.bmcl.2011.10.068
60142962 132706 0 None - 1 Human 8.5 pKi = 8.5 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 552 7 2 9 4.0 COc1cc(C(=O)NC2(C(=O)NC3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)cnc43)CC2)on1 nan
CHEMBL3648488 132706 0 None - 1 Human 8.5 pKi = 8.5 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 552 7 2 9 4.0 COc1cc(C(=O)NC2(C(=O)NC3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)cnc43)CC2)on1 nan
88574592 133975 0 None - 1 Human 8.5 pKi = 8.5 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 588 10 2 8 4.2 COc1cc(C(=O)NC2(C(=O)N[C@H](C)c3ncc(-c4cc(Cl)cc(Cl)c4OCC(F)F)cc3F)COC2)on1 nan
CHEMBL3657626 133975 0 None - 1 Human 8.5 pKi = 8.5 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 588 10 2 8 4.2 COc1cc(C(=O)NC2(C(=O)N[C@H](C)c3ncc(-c4cc(Cl)cc(Cl)c4OCC(F)F)cc3F)COC2)on1 nan
11225601 148805 0 None -6 3 Rabbit 8.5 pKi = 8.5 Binding
Binding affinity to rabbit bradykinin B1 receptorBinding affinity to rabbit bradykinin B1 receptor
ChEMBL 490 7 2 8 4.8 C[C@@H](Nc1nccc(Cl)c1NC(=O)CC#N)c1ccc(-c2cccc(F)c2-c2nnn(C)n2)cc1 10.1021/jm049394l
CHEMBL387638 148805 0 None -6 3 Rabbit 8.5 pKi = 8.5 Binding
Binding affinity to rabbit bradykinin B1 receptorBinding affinity to rabbit bradykinin B1 receptor
ChEMBL 490 7 2 8 4.8 C[C@@H](Nc1nccc(Cl)c1NC(=O)CC#N)c1ccc(-c2cccc(F)c2-c2nnn(C)n2)cc1 10.1021/jm049394l
60142570 132693 0 None - 1 Human 8.5 pKi = 8.5 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 532 6 2 7 4.4 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)c3cncnc3)CC2)no1 nan
CHEMBL3648475 132693 0 None - 1 Human 8.5 pKi = 8.5 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 532 6 2 7 4.4 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)c3cncnc3)CC2)no1 nan
23627396 80627 0 None - 1 Human 8.5 pKi = 8.5 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 618 8 2 5 6.0 O=C(CC1c2ccccc2-c2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)NCCc1ccc(C2=NCCN2)cc1 10.1016/j.bmcl.2012.03.065
CHEMBL2018867 80627 0 None - 1 Human 8.5 pKi = 8.5 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 618 8 2 5 6.0 O=C(CC1c2ccccc2-c2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)NCCc1ccc(C2=NCCN2)cc1 10.1016/j.bmcl.2012.03.065
57342494 84290 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 512 10 1 6 2.6 CN(Cc1ccc(C2=NCCN2)cc1)C(=O)COCCN(C)S(=O)(=O)c1cccc(Cl)c1Cl 10.1021/jm2016057
CHEMBL2087411 84290 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 512 10 1 6 2.6 CN(Cc1ccc(C2=NCCN2)cc1)C(=O)COCCN(C)S(=O)(=O)c1cccc(Cl)c1Cl 10.1021/jm2016057
57383011 133991 0 None - 1 Human 8.5 pKi = 8.5 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 598 10 2 7 4.6 COc1ncc(C(=O)NC2(C(=O)N[C@H](C)c3ccc(-c4cc(Cl)cc(Cl)c4OCC(F)F)cc3F)COC2)cn1 nan
CHEMBL3657642 133991 0 None - 1 Human 8.5 pKi = 8.5 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 598 10 2 7 4.6 COc1ncc(C(=O)NC2(C(=O)N[C@H](C)c3ccc(-c4cc(Cl)cc(Cl)c4OCC(F)F)cc3F)COC2)cn1 nan
44411368 83927 0 None - 1 Human 8.5 pKi = 8.5 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 520 8 1 6 4.8 C/C=C/CN1CCN(C(=O)c2ccc(NCc3ccc(-c4cccc(F)c4C(=O)OC)cc3F)nc2)CC1 10.1016/j.bmcl.2006.01.112
CHEMBL207800 83927 0 None - 1 Human 8.5 pKi = 8.5 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 520 8 1 6 4.8 C/C=C/CN1CCN(C(=O)c2ccc(NCc3ccc(-c4cccc(F)c4C(=O)OC)cc3F)nc2)CC1 10.1016/j.bmcl.2006.01.112
11331054 21993 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptorDisplacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptor
ChEMBL 625 10 2 4 6.8 C=C(CN1CCCCC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2010.06.010
CHEMBL1210743 21993 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptorDisplacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptor
ChEMBL 625 10 2 4 6.8 C=C(CN1CCCCC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2010.06.010
68869570 84299 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 522 9 0 7 1.7 COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCN(C3CC4CCC(C3)N4C)CC2)c(C)c1 10.1021/jm2016057
CHEMBL2087420 84299 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 522 9 0 7 1.7 COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCN(C3CC4CCC(C3)N4C)CC2)c(C)c1 10.1021/jm2016057
44411457 83487 0 None - 1 Human 8.5 pKi = 8.5 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 534 8 1 6 5.0 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(CC4CCC4)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
CHEMBL206519 83487 0 None - 1 Human 8.5 pKi = 8.5 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 534 8 1 6 5.0 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(CC4CCC4)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
44411051 83849 0 None - 1 Human 8.5 pKi = 8.5 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 494 7 1 6 4.2 CCN1CCN(C(=O)c2ccc(NCc3ccc(-c4cccc(F)c4C(=O)OC)cc3F)nc2)CC1 10.1016/j.bmcl.2006.01.112
CHEMBL207377 83849 0 None - 1 Human 8.5 pKi = 8.5 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 494 7 1 6 4.2 CCN1CCN(C(=O)c2ccc(NCc3ccc(-c4cccc(F)c4C(=O)OC)cc3F)nc2)CC1 10.1016/j.bmcl.2006.01.112
49863236 22004 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptorDisplacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptor
ChEMBL 611 11 3 4 6.5 C=C(CNC1CCC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2010.06.010
CHEMBL1210754 22004 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptorDisplacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptor
ChEMBL 611 11 3 4 6.5 C=C(CNC1CCC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2010.06.010
60141324 132723 0 None - 1 Human 8.5 pKi = 8.5 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 552 7 2 10 2.8 COc1cc(C(=O)NC2(C(=O)NC3CCc4cc(-c5cc(Cl)cc(F)c5-c5nnn(C)n5)cnc43)CC2)on1 nan
CHEMBL3648505 132723 0 None - 1 Human 8.5 pKi = 8.5 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 552 7 2 10 2.8 COc1cc(C(=O)NC2(C(=O)NC3CCc4cc(-c5cc(Cl)cc(F)c5-c5nnn(C)n5)cnc43)CC2)on1 nan
57383054 133993 0 None - 1 Human 8.5 pKi = 8.5 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 587 10 2 7 4.8 COc1cc(C(=O)NC2(C(=O)N[C@H](C)c3ccc(-c4cc(Cl)cc(Cl)c4OCC(F)F)cc3F)COC2)on1 nan
CHEMBL3657644 133993 0 None - 1 Human 8.5 pKi = 8.5 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 587 10 2 7 4.8 COc1cc(C(=O)NC2(C(=O)N[C@H](C)c3ccc(-c4cc(Cl)cc(Cl)c4OCC(F)F)cc3F)COC2)on1 nan
44411138 172612 0 None - 1 Human 8.5 pKi = 8.5 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 543 7 1 7 4.8 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(c4cccnc4)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
CHEMBL424868 172612 0 None - 1 Human 8.5 pKi = 8.5 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 543 7 1 7 4.8 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(c4cccnc4)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
11433587 21995 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptorDisplacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptor
ChEMBL 627 10 3 5 5.4 C=C(CN1CC[C@H](O)C1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2010.06.010
CHEMBL1210745 21995 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptorDisplacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptor
ChEMBL 627 10 3 5 5.4 C=C(CN1CC[C@H](O)C1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2010.06.010
68867798 84308 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 469 11 0 6 2.1 COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCC(CCN(C)C)CC2)c(C)c1 10.1021/jm2016057
CHEMBL2087429 84308 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 469 11 0 6 2.1 COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCC(CCN(C)C)CC2)c(C)c1 10.1021/jm2016057
60142703 132695 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 532 6 2 7 4.4 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)c3ccnnc3)CC2)no1 nan
CHEMBL3648477 132695 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 532 6 2 7 4.4 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)c3ccnnc3)CC2)no1 nan
60141182 132717 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 567 7 2 9 3.8 COc1cc(C(=O)NC2(C(=O)N[C@H]3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)ccc43)COC2)on1 nan
CHEMBL3648499 132717 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 567 7 2 9 3.8 COc1cc(C(=O)NC2(C(=O)N[C@H]3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)ccc43)COC2)on1 nan
44430694 94696 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity at human bradykinin B1 receptorBinding affinity at human bradykinin B1 receptor
ChEMBL 500 7 2 5 5.9 N#CC1(c2ccccc2OC(F)(F)F)CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1 10.1016/j.bmcl.2007.03.059
CHEMBL233887 94696 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity at human bradykinin B1 receptorBinding affinity at human bradykinin B1 receptor
ChEMBL 500 7 2 5 5.9 N#CC1(c2ccccc2OC(F)(F)F)CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1 10.1016/j.bmcl.2007.03.059
44430692 94695 1 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity at human bradykinin B1 receptorBinding affinity at human bradykinin B1 receptor
ChEMBL 450 6 2 4 5.7 N#CC1(c2ccccc2Cl)CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1 10.1016/j.bmcl.2007.03.059
CHEMBL233886 94695 1 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity at human bradykinin B1 receptorBinding affinity at human bradykinin B1 receptor
ChEMBL 450 6 2 4 5.7 N#CC1(c2ccccc2Cl)CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1 10.1016/j.bmcl.2007.03.059
44430682 148855 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity at human bradykinin B1 receptorBinding affinity at human bradykinin B1 receptor
ChEMBL 434 6 2 4 5.2 N#CC1(c2cccc(F)c2)CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1 10.1016/j.bmcl.2007.03.059
CHEMBL388030 148855 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity at human bradykinin B1 receptorBinding affinity at human bradykinin B1 receptor
ChEMBL 434 6 2 4 5.2 N#CC1(c2cccc(F)c2)CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1 10.1016/j.bmcl.2007.03.059
16220918 168249 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 585 9 2 6 4.7 O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCOc2cc(CN3CCOCC3)ccc21 10.1021/jm070055c
CHEMBL412762 168249 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 585 9 2 6 4.7 O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCOc2cc(CN3CCOCC3)ccc21 10.1021/jm070055c
11227059 74137 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity to human Bradykinin receptor B1 over-expressed in transgenic rats was determined by ex vivo receptor occupancy assayBinding affinity to human Bradykinin receptor B1 over-expressed in transgenic rats was determined by ex vivo receptor occupancy assay
ChEMBL 584 8 2 7 3.8 O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)NCCc1ccc(-n2cnnc2)cc1 10.1016/j.bmcl.2004.09.074
CHEMBL188617 74137 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity to human Bradykinin receptor B1 over-expressed in transgenic rats was determined by ex vivo receptor occupancy assayBinding affinity to human Bradykinin receptor B1 over-expressed in transgenic rats was determined by ex vivo receptor occupancy assay
ChEMBL 584 8 2 7 3.8 O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)NCCc1ccc(-n2cnnc2)cc1 10.1016/j.bmcl.2004.09.074
44432223 173928 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 545 6 2 7 3.8 C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)CC1)c1ncc(-c2cc(Cl)cc(Cl)c2-c2nnn(C)n2)cc1F 10.1016/j.bmcl.2007.04.040
CHEMBL429074 173928 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 545 6 2 7 3.8 C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)CC1)c1ncc(-c2cc(Cl)cc(Cl)c2-c2nnn(C)n2)cc1F 10.1016/j.bmcl.2007.04.040
70687620 80625 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 624 7 1 5 5.5 O=C(CC1c2ccccc2CCN1S(=O)(=O)c1ccc(Cl)c(Cl)c1)N1CCC(Cc2ccc(C3=NCCN3)cc2)CC1 10.1016/j.bmcl.2012.03.065
CHEMBL2018865 80625 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 624 7 1 5 5.5 O=C(CC1c2ccccc2CCN1S(=O)(=O)c1ccc(Cl)c(Cl)c1)N1CCC(Cc2ccc(C3=NCCN3)cc2)CC1 10.1016/j.bmcl.2012.03.065
11341448 84311 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 524 10 0 7 2.0 COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCC(N3CCN(C(C)C)CC3)CC2)c(C)c1 10.1021/jm2016057
CHEMBL2087432 84311 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 524 10 0 7 2.0 COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCC(N3CCN(C(C)C)CC3)CC2)c(C)c1 10.1021/jm2016057
60142706 132698 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 551 7 2 8 4.6 COc1cc(C(=O)NC2(C(=O)N[C@H]3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)ccc43)CC2)on1 nan
CHEMBL3648480 132698 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 551 7 2 8 4.6 COc1cc(C(=O)NC2(C(=O)N[C@H]3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)ccc43)CC2)on1 nan
44430687 94821 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity at human bradykinin B1 receptorBinding affinity at human bradykinin B1 receptor
ChEMBL 484 6 2 4 6.3 N#CC1(c2ccc(Cl)c(Cl)c2)CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1 10.1016/j.bmcl.2007.03.059
CHEMBL234514 94821 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity at human bradykinin B1 receptorBinding affinity at human bradykinin B1 receptor
ChEMBL 484 6 2 4 6.3 N#CC1(c2ccc(Cl)c(Cl)c2)CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1 10.1016/j.bmcl.2007.03.059
49863237 22005 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptorDisplacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptor
ChEMBL 625 11 3 4 6.9 C=C(CNC1CCCC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2010.06.010
CHEMBL1210755 22005 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptorDisplacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptor
ChEMBL 625 11 3 4 6.9 C=C(CNC1CCCC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2010.06.010
11454567 84309 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 485 11 1 7 1.1 COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCC(C(O)CN(C)C)CC2)c(C)c1 10.1021/jm2016057
CHEMBL2087430 84309 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 485 11 1 7 1.1 COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCC(C(O)CN(C)C)CC2)c(C)c1 10.1021/jm2016057
60142167 132675 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 538 5 2 7 2.9 Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)C(F)(F)F)COC2)n1 nan
CHEMBL3648458 132675 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 538 5 2 7 2.9 Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)C(F)(F)F)COC2)n1 nan
11284303 73116 0 None -2 2 Human 5.5 pKi = 5.5 Binding
Binding affinity for Bradykinin receptor B1 expressed in HEK293 cellsBinding affinity for Bradykinin receptor B1 expressed in HEK293 cells
ChEMBL 553 15 1 7 4.7 CN(C)CCCN(CCCN(C)C)S(=O)(=O)c1ccc(NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 10.1021/jm049747g
CHEMBL185068 73116 0 None -2 2 Human 5.5 pKi = 5.5 Binding
Binding affinity for Bradykinin receptor B1 expressed in HEK293 cellsBinding affinity for Bradykinin receptor B1 expressed in HEK293 cells
ChEMBL 553 15 1 7 4.7 CN(C)CCCN(CCCN(C)C)S(=O)(=O)c1ccc(NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 10.1021/jm049747g
16220913 92326 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 515 8 3 5 4.3 NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 10.1021/jm070055c
CHEMBL227828 92326 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 515 8 3 5 4.3 NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 10.1021/jm070055c
11467345 168730 0 None 489 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cells
ChEMBL 581 9 2 4 6.4 O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1021/jm061224g
CHEMBL415629 168730 0 None 489 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cells
ChEMBL 581 9 2 4 6.4 O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1021/jm061224g
57403175 76337 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity to human B1 bradykinin receptorBinding affinity to human B1 bradykinin receptor
ChEMBL 526 5 1 4 6.9 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3c(Cl)cccc3c2=O)c1 10.1016/j.bmcl.2011.10.068
CHEMBL1934258 76337 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity to human B1 bradykinin receptorBinding affinity to human B1 bradykinin receptor
ChEMBL 526 5 1 4 6.9 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3c(Cl)cccc3c2=O)c1 10.1016/j.bmcl.2011.10.068
44401834 130796 0 None - 1 Human 7.5 pKi = 7.5 Binding
Inhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cellsInhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cells
ChEMBL 442 7 3 4 4.6 CNC(=O)c1ccccc1-c1ccc(CNc2ncccc2NC(=O)CC(F)(F)F)cc1 10.1016/j.bmcl.2005.02.077
CHEMBL362974 130796 0 None - 1 Human 7.5 pKi = 7.5 Binding
Inhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cellsInhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cells
ChEMBL 442 7 3 4 4.6 CNC(=O)c1ccccc1-c1ccc(CNc2ncccc2NC(=O)CC(F)(F)F)cc1 10.1016/j.bmcl.2005.02.077
60142566 132687 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 524 5 2 6 4.3 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)OCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 nan
CHEMBL3648469 132687 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 524 5 2 6 4.3 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)OCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 nan
24895353 185732 3 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 430 6 2 4 4.0 CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccc(F)c(F)c2)cc1 10.1021/jm800199h
CHEMBL470487 185732 3 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 430 6 2 4 4.0 CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccc(F)c(F)c2)cc1 10.1021/jm800199h
11757682 128818 0 None -1949 4 Rat 7.5 pKi = 7.5 Binding
Binding affinity of the [35S]- radiolabeled compound to rat Bradykinin receptor B1Binding affinity of the [35S]- radiolabeled compound to rat Bradykinin receptor B1
ChEMBL 567 8 3 6 3.5 O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc2ccccc2c1)NCCc1ccc(C2=NCCN2)cc1 10.1016/j.bmcl.2004.09.074
CHEMBL359553 128818 0 None -1949 4 Rat 7.5 pKi = 7.5 Binding
Binding affinity of the [35S]- radiolabeled compound to rat Bradykinin receptor B1Binding affinity of the [35S]- radiolabeled compound to rat Bradykinin receptor B1
ChEMBL 567 8 3 6 3.5 O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc2ccccc2c1)NCCc1ccc(C2=NCCN2)cc1 10.1016/j.bmcl.2004.09.074
44411392 148034 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 524 6 1 7 4.0 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(C(=O)OC)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
CHEMBL383089 148034 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 524 6 1 7 4.0 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(C(=O)OC)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
49863227 21991 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptorDisplacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptor
ChEMBL 627 10 2 4 6.9 CC(CN1CCCCC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2010.06.010
CHEMBL1210741 21991 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptorDisplacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptor
ChEMBL 627 10 2 4 6.9 CC(CN1CCCCC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2010.06.010
68869351 84298 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 508 9 0 7 1.2 COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCN([C@H]3CN4CCC3CC4)CC2)c(C)c1 10.1021/jm2016057
CHEMBL2087419 84298 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 508 9 0 7 1.2 COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCN([C@H]3CN4CCC3CC4)CC2)c(C)c1 10.1021/jm2016057
44569936 179964 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]desArg from human B1 in human WI 38 cellsDisplacement of [3H]desArg from human B1 in human WI 38 cells
ChEMBL 627 14 1 6 5.9 COc1cc(CN(CC(=O)NCc2ccccc2Cl)S(=O)(=O)c2ccc(CN3CCCCC3)cc2)ccc1OCC(C)C 10.1016/j.bmcl.2008.11.005
CHEMBL452238 179964 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]desArg from human B1 in human WI 38 cellsDisplacement of [3H]desArg from human B1 in human WI 38 cells
ChEMBL 627 14 1 6 5.9 COc1cc(CN(CC(=O)NCc2ccccc2Cl)S(=O)(=O)c2ccc(CN3CCCCC3)cc2)ccc1OCC(C)C 10.1016/j.bmcl.2008.11.005
11495796 80310 0 None - 1 Human 5.5 pKi = 5.5 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 436 7 2 4 3.6 COC(=O)c1ccccc1-c1ccc(CNC(=O)C(C)(C)NC(=O)CC(F)(F)F)cc1 10.1021/jm0511280
CHEMBL201717 80310 0 None - 1 Human 5.5 pKi = 5.5 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 436 7 2 4 3.6 COC(=O)c1ccccc1-c1ccc(CNC(=O)C(C)(C)NC(=O)CC(F)(F)F)cc1 10.1021/jm0511280
44391980 71790 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity against Human bradykinin receptor B1Binding affinity against Human bradykinin receptor B1
ChEMBL 418 7 2 6 4.4 COC(=O)C1=C(c2ccc(CNc3nccc(C)c3NC(=O)CC#N)cc2)CCCC1 10.1016/j.bmcl.2005.05.133
CHEMBL182331 71790 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity against Human bradykinin receptor B1Binding affinity against Human bradykinin receptor B1
ChEMBL 418 7 2 6 4.4 COC(=O)C1=C(c2ccc(CNc3nccc(C)c3NC(=O)CC#N)cc2)CCCC1 10.1016/j.bmcl.2005.05.133
11442712 92001 0 None -89 3 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]des-arg10 kallidin from rat bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-arg10 kallidin from rat bradykinin B1 receptor expressed in CHO cells
ChEMBL 466 7 2 6 5.4 COC(=O)c1c(F)cccc1-c1ccc([C@@H](C)Nc2nccc(Cl)c2NC(=O)CC#N)cc1 10.1021/jm049394l
CHEMBL225607 92001 0 None -89 3 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]des-arg10 kallidin from rat bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-arg10 kallidin from rat bradykinin B1 receptor expressed in CHO cells
ChEMBL 466 7 2 6 5.4 COC(=O)c1c(F)cccc1-c1ccc([C@@H](C)Nc2nccc(Cl)c2NC(=O)CC#N)cc1 10.1021/jm049394l
11386138 91216 0 None -50 3 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]des-arg10 kallidin from rat bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-arg10 kallidin from rat bradykinin B1 receptor expressed in CHO cells
ChEMBL 482 7 2 6 5.9 COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)Nc2nccc(Cl)c2NC(=O)CC#N)cc1 10.1021/jm049394l
CHEMBL221998 91216 0 None -50 3 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]des-arg10 kallidin from rat bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-arg10 kallidin from rat bradykinin B1 receptor expressed in CHO cells
ChEMBL 482 7 2 6 5.9 COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)Nc2nccc(Cl)c2NC(=O)CC#N)cc1 10.1021/jm049394l
44392010 72633 0 None - 1 Human 5.5 pKi = 5.5 Binding
Binding affinity against Human bradykinin receptor B1Binding affinity against Human bradykinin receptor B1
ChEMBL 435 7 2 7 3.7 COC(=O)c1ccccc1N1CCC(C)(CNc2nccc(C)c2NC(=O)CC#N)CC1 10.1016/j.bmcl.2005.05.133
CHEMBL183538 72633 0 None - 1 Human 5.5 pKi = 5.5 Binding
Binding affinity against Human bradykinin receptor B1Binding affinity against Human bradykinin receptor B1
ChEMBL 435 7 2 7 3.7 COC(=O)c1ccccc1N1CCC(C)(CNc2nccc(C)c2NC(=O)CC#N)CC1 10.1016/j.bmcl.2005.05.133
60142569 132692 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 426 4 2 5 4.1 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(N)CC2)no1 nan
CHEMBL3648474 132692 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 426 4 2 5 4.1 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(N)CC2)no1 nan
60142837 132704 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 527 5 2 7 5.1 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)OC(C)(C)C)CC2)no1 nan
CHEMBL3648486 132704 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 527 5 2 7 5.1 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)OC(C)(C)C)CC2)no1 nan
16220988 92310 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 589 9 3 5 5.6 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccccc1C(F)(F)F)c1ccccc1 10.1021/jm070055c
CHEMBL227697 92310 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 589 9 3 5 5.6 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccccc1C(F)(F)F)c1ccccc1 10.1021/jm070055c
25181410 178993 1 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 642 14 1 7 4.6 COc1cc(CN(CC(=O)NCc2ccccc2Cl)S(=O)(=O)c2ccc(CN3CCN(C)CC3)cc2)ccc1OCC(C)C 10.1021/jm1000776
CHEMBL447392 178993 1 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 642 14 1 7 4.6 COc1cc(CN(CC(=O)NCc2ccccc2Cl)S(=O)(=O)c2ccc(CN3CCN(C)CC3)cc2)ccc1OCC(C)C 10.1021/jm1000776
60142166 132674 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 538 5 2 6 4.1 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)C(F)(F)F)COC2)no1 nan
CHEMBL3648457 132674 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 538 5 2 6 4.1 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)C(F)(F)F)COC2)no1 nan
44392040 179659 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity against Human bradykinin receptor B1Binding affinity against Human bradykinin receptor B1
ChEMBL 444 7 2 6 4.3 COC(=O)C1C2C=CC(CC2)C1c1ccc(CNc2nccc(C)c2NC(=O)CC#N)cc1 10.1016/j.bmcl.2005.05.133
CHEMBL451549 179659 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity against Human bradykinin receptor B1Binding affinity against Human bradykinin receptor B1
ChEMBL 444 7 2 6 4.3 COC(=O)C1C2C=CC(CC2)C1c1ccc(CNc2nccc(C)c2NC(=O)CC#N)cc1 10.1016/j.bmcl.2005.05.133
60142165 132673 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 496 5 2 5 3.3 COC(=O)c1c(Cl)cccc1-c1ccc2c(c1)CC[C@@H]2NC(=O)C1(NC(=O)C(F)(F)F)COC1 nan
CHEMBL3648456 132673 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 496 5 2 5 3.3 COC(=O)c1c(Cl)cccc1-c1ccc2c(c1)CC[C@@H]2NC(=O)C1(NC(=O)C(F)(F)F)COC1 nan
123884 9086 14 None -87 3 Human 6.4 pKi = 6.4 Binding
Ability to bind to human cloned B1 receptor in competition binding experiments with [3H][des-Arg10,Leu9]-Kallidin.Ability to bind to human cloned B1 receptor in competition binding experiments with [3H][des-Arg10,Leu9]-Kallidin.
ChEMBL None None None None 10.1021/jm990961s
641 9086 14 None -87 3 Human 6.4 pKi = 6.4 Binding
Ability to bind to human cloned B1 receptor in competition binding experiments with [3H][des-Arg10,Leu9]-Kallidin.Ability to bind to human cloned B1 receptor in competition binding experiments with [3H][des-Arg10,Leu9]-Kallidin.
ChEMBL None None None None 10.1021/jm990961s
CHEMBL80472 9086 14 None -87 3 Human 6.4 pKi = 6.4 Binding
Ability to bind to human cloned B1 receptor in competition binding experiments with [3H][des-Arg10,Leu9]-Kallidin.Ability to bind to human cloned B1 receptor in competition binding experiments with [3H][des-Arg10,Leu9]-Kallidin.
ChEMBL None None None None 10.1021/jm990961s
16108967 91119 0 None 147 2 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cells
ChEMBL 541 10 2 4 5.6 O=C(CC(NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)NCc1ccc(CN2CCCCC2)cc1 10.1021/jm061224g
CHEMBL221691 91119 0 None 147 2 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cells
ChEMBL 541 10 2 4 5.6 O=C(CC(NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)NCc1ccc(CN2CCCCC2)cc1 10.1021/jm061224g
44391962 71509 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity against Human bradykinin receptor B1Binding affinity against Human bradykinin receptor B1
ChEMBL 420 7 2 6 4.4 COC(=O)c1ccccc1C1CCC(CNc2nccc(C)c2NC(=O)CC#N)CC1 10.1016/j.bmcl.2005.05.133
CHEMBL181899 71509 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity against Human bradykinin receptor B1Binding affinity against Human bradykinin receptor B1
ChEMBL 420 7 2 6 4.4 COC(=O)c1ccccc1C1CCC(CNc2nccc(C)c2NC(=O)CC#N)CC1 10.1016/j.bmcl.2005.05.133
10001334 76900 0 None - 1 Human 6.4 pKi = 6.4 Binding
Inhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cellsInhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cells
ChEMBL 405 8 2 6 3.7 COCC(=O)Nc1cccnc1NCc1ccc(-c2ccccc2C(=O)OC)cc1 10.1016/j.bmcl.2005.02.077
CHEMBL194018 76900 0 None - 1 Human 6.4 pKi = 6.4 Binding
Inhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cellsInhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cells
ChEMBL 405 8 2 6 3.7 COCC(=O)Nc1cccnc1NCc1ccc(-c2ccccc2C(=O)OC)cc1 10.1016/j.bmcl.2005.02.077
16220986 144395 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 555 9 3 5 5.3 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccccc1Cl)c1ccccc1 10.1021/jm070055c
CHEMBL375709 144395 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 555 9 3 5 5.3 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccccc1Cl)c1ccccc1 10.1021/jm070055c
57403174 76335 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity to human B1 bradykinin receptorBinding affinity to human B1 bradykinin receptor
ChEMBL 510 5 1 4 6.4 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3ccc(F)cc3c2=O)c1 10.1016/j.bmcl.2011.10.068
CHEMBL1934256 76335 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity to human B1 bradykinin receptorBinding affinity to human B1 bradykinin receptor
ChEMBL 510 5 1 4 6.4 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3ccc(F)cc3c2=O)c1 10.1016/j.bmcl.2011.10.068
60142963 132707 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 533 6 2 8 3.8 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)c3ccnnc3)CC2)no1 nan
CHEMBL3648489 132707 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 533 6 2 8 3.8 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)c3ccnnc3)CC2)no1 nan
60143095 132708 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 563 7 2 9 3.8 COc1ncc(C(=O)NC2(C(=O)NC3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)cnc43)CC2)cn1 nan
CHEMBL3648490 132708 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 563 7 2 9 3.8 COc1ncc(C(=O)NC2(C(=O)NC3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)cnc43)CC2)cn1 nan
56835162 76339 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity to human B1 bradykinin receptorBinding affinity to human B1 bradykinin receptor
ChEMBL 526 5 1 4 6.9 O=C(N[C@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3cccc(Cl)c3c2=O)cc1 10.1016/j.bmcl.2011.10.068
CHEMBL1934260 76339 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity to human B1 bradykinin receptorBinding affinity to human B1 bradykinin receptor
ChEMBL 526 5 1 4 6.9 O=C(N[C@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3cccc(Cl)c3c2=O)cc1 10.1016/j.bmcl.2011.10.068
44411343 84039 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 520 9 1 6 4.8 C=CCCN1CCN(C(=O)c2ccc(NCc3ccc(-c4cccc(F)c4C(=O)OC)cc3F)nc2)CC1 10.1016/j.bmcl.2006.01.112
CHEMBL208006 84039 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 520 9 1 6 4.8 C=CCCN1CCN(C(=O)c2ccc(NCc3ccc(-c4cccc(F)c4C(=O)OC)cc3F)nc2)CC1 10.1016/j.bmcl.2006.01.112
60142704 132696 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 521 6 2 7 4.6 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)c3ccno3)CC2)no1 nan
CHEMBL3648478 132696 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 521 6 2 7 4.6 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)c3ccno3)CC2)no1 nan
11635365 181340 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells
ChEMBL 554 8 3 6 3.4 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2008.07.108
CHEMBL455642 181340 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells
ChEMBL 554 8 3 6 3.4 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2008.07.108
57342496 84291 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 512 10 1 6 2.6 CN(Cc1ccc(C2=NCCN2)cc1)C(=O)COCCN(C)S(=O)(=O)c1c(Cl)cccc1Cl 10.1021/jm2016057
CHEMBL2087412 84291 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 512 10 1 6 2.6 CN(Cc1ccc(C2=NCCN2)cc1)C(=O)COCCN(C)S(=O)(=O)c1c(Cl)cccc1Cl 10.1021/jm2016057
57382921 131197 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 545 6 2 8 2.5 C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)COC1)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F nan
CHEMBL3639564 131197 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 545 6 2 8 2.5 C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)COC1)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F nan
57383055 133994 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 572 9 2 7 4.5 Cc1nnc(C(=O)NC2(C(=O)N[C@H](C)c3ccc(-c4cc(Cl)cc(Cl)c4OCC(F)F)cc3F)COC2)o1 nan
CHEMBL3657645 133994 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 572 9 2 7 4.5 Cc1nnc(C(=O)NC2(C(=O)N[C@H](C)c3ccc(-c4cc(Cl)cc(Cl)c4OCC(F)F)cc3F)COC2)o1 nan
70693873 80623 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 576 8 2 5 5.4 O=C(CC1CCc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)N[C@H]1CC[C@H](CCC2=NCCN2)CC1 10.1016/j.bmcl.2012.03.065
CHEMBL2018863 80623 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 576 8 2 5 5.4 O=C(CC1CCc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)N[C@H]1CC[C@H](CCC2=NCCN2)CC1 10.1016/j.bmcl.2012.03.065
57342849 84292 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 508 11 1 7 2.0 COc1ccc(S(=O)(=O)N(C)CCOCC(=O)N(C)Cc2ccc(C3=NCCN3)cc2)c(Cl)c1 10.1021/jm2016057
CHEMBL2087413 84292 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 508 11 1 7 2.0 COc1ccc(S(=O)(=O)N(C)CCOCC(=O)N(C)Cc2ccc(C3=NCCN3)cc2)c(Cl)c1 10.1021/jm2016057
60142303 132680 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 523 5 2 6 4.2 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 nan
CHEMBL3648462 132680 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 523 5 2 6 4.2 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 nan
60141466 132728 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 569 7 2 10 3.6 COc1cc(C(=O)NC2(C(=O)NC3CSc4cc(-c5cc(Cl)cc(F)c5-c5nnn(C)n5)ccc43)CC2)on1 nan
CHEMBL3648510 132728 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 569 7 2 10 3.6 COc1cc(C(=O)NC2(C(=O)NC3CSc4cc(-c5cc(Cl)cc(F)c5-c5nnn(C)n5)ccc43)CC2)on1 nan
16047262 83983 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 480 6 1 6 3.8 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(C)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
CHEMBL207937 83983 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 480 6 1 6 3.8 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(C)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
60141185 132720 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 563 7 2 10 2.6 COc1ncc(C(=O)NC2(C(=O)NC3CCc4cc(-c5cc(Cl)cc(F)c5-c5nnn(C)n5)cnc43)CC2)cn1 nan
CHEMBL3648502 132720 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 563 7 2 10 2.6 COc1ncc(C(=O)NC2(C(=O)NC3CCc4cc(-c5cc(Cl)cc(F)c5-c5nnn(C)n5)cnc43)CC2)cn1 nan
11260745 84303 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 510 10 0 7 1.4 COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCN(CC3CCN(C)CC3)CC2)c(C)c1 10.1021/jm2016057
CHEMBL2087424 84303 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 510 10 0 7 1.4 COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCN(CC3CCN(C)CC3)CC2)c(C)c1 10.1021/jm2016057
46911684 22003 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptorDisplacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptor
ChEMBL 599 11 3 4 6.3 C=C(CNC(C)C)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2010.06.010
CHEMBL1210753 22003 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptorDisplacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptor
ChEMBL 599 11 3 4 6.3 C=C(CNC(C)C)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2010.06.010
57382797 133967 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 558 9 2 7 4.2 C[C@@H](NC(=O)C1(NC(=O)c2ccno2)COC1)c1ncc(-c2cc(Cl)cc(Cl)c2OCC(F)F)cc1F nan
CHEMBL3657618 133967 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 558 9 2 7 4.2 C[C@@H](NC(=O)C1(NC(=O)c2ccno2)COC1)c1ncc(-c2cc(Cl)cc(Cl)c2OCC(F)F)cc1F nan
23627458 80629 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 564 8 2 5 5.0 Cc1ccc(S(=O)(=O)N2c3ccccc3-c3ccccc3C2CC(=O)NCCc2ccc(C3=NCCN3)cc2)cc1 10.1016/j.bmcl.2012.03.065
CHEMBL2018869 80629 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 564 8 2 5 5.0 Cc1ccc(S(=O)(=O)N2c3ccccc3-c3ccccc3C2CC(=O)NCCc2ccc(C3=NCCN3)cc2)cc1 10.1016/j.bmcl.2012.03.065
16221228 172796 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 593 10 3 5 5.4 CC(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1 10.1021/jm070055c
CHEMBL425490 172796 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 593 10 3 5 5.4 CC(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1 10.1021/jm070055c
68870388 84314 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 510 10 0 7 1.4 COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCC(CN3CCN(C)CC3)CC2)c(C)c1 10.1021/jm2016057
CHEMBL2087435 84314 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 510 10 0 7 1.4 COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCC(CN3CCN(C)CC3)CC2)c(C)c1 10.1021/jm2016057
60141041 132714 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 548 6 2 8 3.6 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)c3cncnc3)COC2)no1 nan
CHEMBL3648496 132714 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 548 6 2 8 3.6 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)c3cncnc3)COC2)no1 nan
60141464 132726 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 550 6 2 9 3.4 Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)SCC3NC(=O)C2(NC(=O)c3cncnc3)CC2)n1 nan
CHEMBL3648508 132726 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 550 6 2 9 3.4 Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)SCC3NC(=O)C2(NC(=O)c3cncnc3)CC2)n1 nan
16221055 149526 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 607 9 3 5 5.8 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1 10.1021/jm070055c
CHEMBL389249 149526 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 607 9 3 5 5.8 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1 10.1021/jm070055c
44430688 94934 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity at human bradykinin B1 receptorBinding affinity at human bradykinin B1 receptor
ChEMBL 484 6 2 4 6.3 N#CC1(c2cccc(Cl)c2Cl)CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1 10.1016/j.bmcl.2007.03.059
CHEMBL234720 94934 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity at human bradykinin B1 receptorBinding affinity at human bradykinin B1 receptor
ChEMBL 484 6 2 4 6.3 N#CC1(c2cccc(Cl)c2Cl)CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1 10.1016/j.bmcl.2007.03.059
10456579 131395 0 None - 1 Human 7.4 pKi = 7.4 Binding
Inhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cellsInhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cells
ChEMBL 453 8 2 7 3.1 COC(=O)c1ccccc1-c1ccc(CNc2ncccc2NC(=O)CS(C)(=O)=O)cc1 10.1016/j.bmcl.2005.02.077
CHEMBL364073 131395 0 None - 1 Human 7.4 pKi = 7.4 Binding
Inhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cellsInhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cells
ChEMBL 453 8 2 7 3.1 COC(=O)c1ccccc1-c1ccc(CNc2ncccc2NC(=O)CS(C)(=O)=O)cc1 10.1016/j.bmcl.2005.02.077
16221226 151176 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 569 9 3 5 5.6 Cc1c(Cl)cccc1S(=O)(=O)N[C@H](CC(=O)N[C@@H]1CCOc2cc(CNC(C)(C)C)ccc21)c1ccccc1 10.1021/jm070055c
CHEMBL390603 151176 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 569 9 3 5 5.6 Cc1c(Cl)cccc1S(=O)(=O)N[C@H](CC(=O)N[C@@H]1CCOc2cc(CNC(C)(C)C)ccc21)c1ccccc1 10.1021/jm070055c
11663606 201358 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells
ChEMBL 520 8 2 5 4.5 O=C(C[C@H](O)CS(=O)(=O)c1ccc2ccccc2c1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2008.07.108
CHEMBL530554 201358 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells
ChEMBL 520 8 2 5 4.5 O=C(C[C@H](O)CS(=O)(=O)c1ccc2ccccc2c1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2008.07.108
11466010 91189 0 None -6 3 Rabbit 7.4 pKi = 7.4 Binding
Binding affinity to rabbit bradykinin B1 receptorBinding affinity to rabbit bradykinin B1 receptor
ChEMBL 490 7 2 8 4.8 C[C@@H](Nc1nccc(Cl)c1NC(=O)CC#N)c1ccc(-c2cccc(F)c2-c2nnnn2C)cc1 10.1021/jm049394l
CHEMBL221984 91189 0 None -6 3 Rabbit 7.4 pKi = 7.4 Binding
Binding affinity to rabbit bradykinin B1 receptorBinding affinity to rabbit bradykinin B1 receptor
ChEMBL 490 7 2 8 4.8 C[C@@H](Nc1nccc(Cl)c1NC(=O)CC#N)c1ccc(-c2cccc(F)c2-c2nnnn2C)cc1 10.1021/jm049394l
60142302 132679 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 536 5 2 5 5.2 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CCCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 nan
CHEMBL3648461 132679 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 536 5 2 5 5.2 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CCCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 nan
44569940 185510 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]desArg from human B1 in human WI 38 cellsDisplacement of [3H]desArg from human B1 in human WI 38 cells
ChEMBL 514 11 2 5 3.1 O=C(O)CCNC(=O)CN(CCOc1ccc2c(c1)CCC2)S(=O)(=O)c1ccc(Cl)cc1Cl 10.1016/j.bmcl.2008.11.005
CHEMBL468493 185510 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]desArg from human B1 in human WI 38 cellsDisplacement of [3H]desArg from human B1 in human WI 38 cells
ChEMBL 514 11 2 5 3.1 O=C(O)CCNC(=O)CN(CCOc1ccc2c(c1)CCC2)S(=O)(=O)c1ccc(Cl)cc1Cl 10.1016/j.bmcl.2008.11.005
57401426 76341 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity to human B1 bradykinin receptorBinding affinity to human B1 bradykinin receptor
ChEMBL 526 5 1 4 6.9 O=C(N[C@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3cc(Cl)ccc3c2=O)cc1 10.1016/j.bmcl.2011.10.068
CHEMBL1934262 76341 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity to human B1 bradykinin receptorBinding affinity to human B1 bradykinin receptor
ChEMBL 526 5 1 4 6.9 O=C(N[C@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3cc(Cl)ccc3c2=O)cc1 10.1016/j.bmcl.2011.10.068
49863233 22000 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptorDisplacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptor
ChEMBL 615 13 3 5 5.6 C=C(CNCCOC)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2010.06.010
CHEMBL1210750 22000 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptorDisplacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptor
ChEMBL 615 13 3 5 5.6 C=C(CNCCOC)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2010.06.010
57399670 76332 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity to human B1 bradykinin receptorBinding affinity to human B1 bradykinin receptor
ChEMBL 506 5 1 5 5.5 Cc1nn(-c2ccc(C(=O)N[C@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2ccccc12 10.1016/j.bmcl.2011.10.068
CHEMBL1934253 76332 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity to human B1 bradykinin receptorBinding affinity to human B1 bradykinin receptor
ChEMBL 506 5 1 5 5.5 Cc1nn(-c2ccc(C(=O)N[C@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2ccccc12 10.1016/j.bmcl.2011.10.068
24895449 193496 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 413 6 2 5 3.2 CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccc(F)nc2)cc1 10.1021/jm800199h
CHEMBL488626 193496 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 413 6 2 5 3.2 CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccc(F)nc2)cc1 10.1021/jm800199h
11620980 180491 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells
ChEMBL 554 8 3 6 3.4 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1ccccc1C(F)(F)F 10.1016/j.bmcl.2008.07.108
CHEMBL453596 180491 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells
ChEMBL 554 8 3 6 3.4 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1ccccc1C(F)(F)F 10.1016/j.bmcl.2008.07.108
24895355 193478 3 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 395 6 2 5 3.1 CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccncc2)cc1 10.1021/jm800199h
CHEMBL488461 193478 3 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 395 6 2 5 3.1 CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccncc2)cc1 10.1021/jm800199h
4227718 185825 7 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 394 6 2 4 3.7 CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1 10.1021/jm800199h
CHEMBL471371 185825 7 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 394 6 2 4 3.7 CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1 10.1021/jm800199h
4227718 185825 7 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]Lys0-des-Arg9-BK at human bradykinin B1 receptor expressed in HEK293 cellsDisplacement of [3H]Lys0-des-Arg9-BK at human bradykinin B1 receptor expressed in HEK293 cells
ChEMBL 394 6 2 4 3.7 CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1 10.1021/jm1000776
CHEMBL471371 185825 7 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]Lys0-des-Arg9-BK at human bradykinin B1 receptor expressed in HEK293 cellsDisplacement of [3H]Lys0-des-Arg9-BK at human bradykinin B1 receptor expressed in HEK293 cells
ChEMBL 394 6 2 4 3.7 CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1 10.1021/jm1000776
60142833 132700 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 444 4 2 5 4.2 Cc1nc(-c2c(F)cc(Cl)cc2-c2cc(F)c3c(c2)CCC3NC(=O)C2(N)CC2)no1 nan
CHEMBL3648482 132700 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 444 4 2 5 4.2 Cc1nc(-c2c(F)cc(Cl)cc2-c2cc(F)c3c(c2)CCC3NC(=O)C2(N)CC2)no1 nan
11641218 80007 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 462 7 2 4 4.1 COC(=O)c1ccccc1-c1ccc(CNC(=O)C2(NC(=O)CC(F)(F)F)CCCC2)cc1 10.1021/jm0511280
CHEMBL201210 80007 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 462 7 2 4 4.1 COC(=O)c1ccccc1-c1ccc(CNC(=O)C2(NC(=O)CC(F)(F)F)CCCC2)cc1 10.1021/jm0511280
60142707 132699 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 544 5 2 6 5.8 Cc1nc(-c2c(F)cc(Cl)cc2-c2cc(F)c3c(c2)CCC3NC(=O)C2(NC(=O)OC(C)(C)C)CC2)no1 nan
CHEMBL3648481 132699 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 544 5 2 6 5.8 Cc1nc(-c2c(F)cc(Cl)cc2-c2cc(F)c3c(c2)CCC3NC(=O)C2(NC(=O)OC(C)(C)C)CC2)no1 nan
11596635 93591 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding affinity at human bradykinin B1 receptorBinding affinity at human bradykinin B1 receptor
ChEMBL 407 6 3 4 4.5 O=C(CC(F)(F)F)Nc1cccnc1NCC1CCC(O)(c2ccccc2)CC1 10.1016/j.bmcl.2007.03.059
CHEMBL232237 93591 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding affinity at human bradykinin B1 receptorBinding affinity at human bradykinin B1 receptor
ChEMBL 407 6 3 4 4.5 O=C(CC(F)(F)F)Nc1cccnc1NCC1CCC(O)(c2ccccc2)CC1 10.1016/j.bmcl.2007.03.059
44455147 104831 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 403 5 2 4 3.0 COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)[C@H](O)C(F)(F)F)c(F)c1 10.1016/j.bmcl.2007.11.050
CHEMBL273156 104831 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 403 5 2 4 3.0 COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)[C@H](O)C(F)(F)F)c(F)c1 10.1016/j.bmcl.2007.11.050
11635364 181341 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells
ChEMBL 554 8 3 6 3.4 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1ccc(C(F)(F)F)cc1 10.1016/j.bmcl.2008.07.108
CHEMBL455643 181341 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells
ChEMBL 554 8 3 6 3.4 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1ccc(C(F)(F)F)cc1 10.1016/j.bmcl.2008.07.108
70689675 80618 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 572 8 2 6 4.0 O=C(CC1COc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)NCCc1ccc(C2=NCCN2)cc1 10.1016/j.bmcl.2012.03.065
CHEMBL2018858 80618 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 572 8 2 6 4.0 O=C(CC1COc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)NCCc1ccc(C2=NCCN2)cc1 10.1016/j.bmcl.2012.03.065
57392728 76342 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding affinity to human B1 bradykinin receptorBinding affinity to human B1 bradykinin receptor
ChEMBL 526 5 1 4 6.9 O=C(N[C@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3c(Cl)cccc3c2=O)cc1 10.1016/j.bmcl.2011.10.068
CHEMBL1934263 76342 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding affinity to human B1 bradykinin receptorBinding affinity to human B1 bradykinin receptor
ChEMBL 526 5 1 4 6.9 O=C(N[C@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3c(Cl)cccc3c2=O)cc1 10.1016/j.bmcl.2011.10.068
70685470 80620 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 570 8 2 5 4.2 O=C(CC1Cc2ccccc2CN1S(=O)(=O)c1ccc(Cl)c(Cl)c1)NCCc1ccc(C2=NCCN2)cc1 10.1016/j.bmcl.2012.03.065
CHEMBL2018860 80620 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 570 8 2 5 4.2 O=C(CC1Cc2ccccc2CN1S(=O)(=O)c1ccc(Cl)c(Cl)c1)NCCc1ccc(C2=NCCN2)cc1 10.1016/j.bmcl.2012.03.065
44430685 94820 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity at human bradykinin B1 receptorBinding affinity at human bradykinin B1 receptor
ChEMBL 474 7 2 6 4.8 COC(=O)c1cccc(C2(C#N)CCC(CNc3ncccc3NC(=O)CC(F)(F)F)CC2)c1 10.1016/j.bmcl.2007.03.059
CHEMBL234513 94820 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity at human bradykinin B1 receptorBinding affinity at human bradykinin B1 receptor
ChEMBL 474 7 2 6 4.8 COC(=O)c1cccc(C2(C#N)CCC(CNc3ncccc3NC(=O)CC(F)(F)F)CC2)c1 10.1016/j.bmcl.2007.03.059
16221111 92314 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 571 11 3 5 5.6 CC(C)CNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 10.1021/jm070055c
CHEMBL227721 92314 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 571 11 3 5 5.6 CC(C)CNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 10.1021/jm070055c
16221109 150825 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 607 9 3 5 6.1 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(Cl)c(Cl)c1)c1ccc(F)cc1 10.1021/jm070055c
CHEMBL390311 150825 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 607 9 3 5 6.1 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(Cl)c(Cl)c1)c1ccc(F)cc1 10.1021/jm070055c
88574478 133966 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 572 9 2 7 4.5 Cc1cc(C(=O)NC2(C(=O)N[C@H](C)c3ncc(-c4cc(Cl)cc(Cl)c4OCC(F)F)cc3F)COC2)on1 nan
CHEMBL3657617 133966 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 572 9 2 7 4.5 Cc1cc(C(=O)NC2(C(=O)N[C@H](C)c3ncc(-c4cc(Cl)cc(Cl)c4OCC(F)F)cc3F)COC2)on1 nan
57382880 133976 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 559 7 2 10 3.1 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)C3(NC(=O)c4nnc(C)o4)COC3)c(F)c2)no1 nan
CHEMBL3657627 133976 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 559 7 2 10 3.1 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)C3(NC(=O)c4nnc(C)o4)COC3)c(F)c2)no1 nan
11620871 172814 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity to human BK1 receptor Q295 mutantBinding affinity to human BK1 receptor Q295 mutant
ChEMBL 543 7 1 7 4.8 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(c4ccncc4)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
CHEMBL425588 172814 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity to human BK1 receptor Q295 mutantBinding affinity to human BK1 receptor Q295 mutant
ChEMBL 543 7 1 7 4.8 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(c4ccncc4)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
44411068 147690 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 512 8 1 6 4.2 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(CCF)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
CHEMBL382228 147690 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 512 8 1 6 4.2 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(CCF)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
57382795 133965 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 516 7 2 5 3.9 COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)CC(F)(F)F)COC2)c(F)c1 nan
CHEMBL3657616 133965 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 516 7 2 5 3.9 COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)CC(F)(F)F)COC2)c(F)c1 nan
60141038 132712 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 564 7 2 9 3.8 COc1ncc(C(=O)NC2(C(=O)NC3COc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)ccc43)CC2)cn1 nan
CHEMBL3648494 132712 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 564 7 2 9 3.8 COc1ncc(C(=O)NC2(C(=O)NC3COc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)ccc43)CC2)cn1 nan
16220916 92336 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 571 9 3 5 5.8 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 10.1021/jm070055c
CHEMBL227879 92336 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 571 9 3 5 5.8 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 10.1021/jm070055c
44411393 83782 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 466 6 2 6 3.5 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCNCC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
CHEMBL207122 83782 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 466 6 2 6 3.5 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCNCC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
16221108 92306 0 None 27 2 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 605 9 2 5 5.5 O=C(C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1)N[C@@H]1CCOc2cc(CN3CCCC3)ccc21 10.1021/jm070055c
CHEMBL227600 92306 0 None 27 2 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 605 9 2 5 5.5 O=C(C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1)N[C@@H]1CCOc2cc(CN3CCCC3)ccc21 10.1021/jm070055c
57342847 84289 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 488 11 1 7 1.6 COc1ccc(S(=O)(=O)N(C)CCOCC(=O)N(C)Cc2ccc(C3=NCCN3)cc2)c(C)c1 10.1021/jm2016057
CHEMBL2087410 84289 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 488 11 1 7 1.6 COc1ccc(S(=O)(=O)N(C)CCOCC(=O)N(C)Cc2ccc(C3=NCCN3)cc2)c(C)c1 10.1021/jm2016057
44316621 88891 0 None 57 2 Human 8.3 pKi = 8.3 Binding
Ability to bind to human cloned B1 receptor in competition binding experiments with [3H][des-Arg10,Leu9]-Kallidin.Ability to bind to human cloned B1 receptor in competition binding experiments with [3H][des-Arg10,Leu9]-Kallidin.
ChEMBL 1091 24 13 15 -4.9 NC(N)=NCCCC(N)C(=O)N[C@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1CC(O)C[C@H]1C(=O)NCC(=O)NC(C(=O)N[C@@H](CO)C(=O)N[C@@H]1CSc2ccccc2N(CC(=O)O)C1=O)C1Cc2ccccc2C1 10.1021/jm990961s
CHEMBL216618 88891 0 None 57 2 Human 8.3 pKi = 8.3 Binding
Ability to bind to human cloned B1 receptor in competition binding experiments with [3H][des-Arg10,Leu9]-Kallidin.Ability to bind to human cloned B1 receptor in competition binding experiments with [3H][des-Arg10,Leu9]-Kallidin.
ChEMBL 1091 24 13 15 -4.9 NC(N)=NCCCC(N)C(=O)N[C@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1CC(O)C[C@H]1C(=O)NCC(=O)NC(C(=O)N[C@@H](CO)C(=O)N[C@@H]1CSc2ccccc2N(CC(=O)O)C1=O)C1Cc2ccccc2C1 10.1021/jm990961s
24895255 192155 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 556 10 3 5 5.0 O=C(NCCCN1CCCC(F)(F)C1)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1 10.1021/jm800199h
CHEMBL486052 192155 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 556 10 3 5 5.0 O=C(NCCCN1CCCC(F)(F)C1)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1 10.1021/jm800199h
9852117 84297 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 508 9 0 7 1.2 COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCN([C@@H]3CN4CCC3CC4)CC2)c(C)c1 10.1021/jm2016057
CHEMBL2087418 84297 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 508 9 0 7 1.2 COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCN([C@@H]3CN4CCC3CC4)CC2)c(C)c1 10.1021/jm2016057
16221161 151099 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 569 9 2 5 5.5 O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCOc2cc(CN3CCCC3)ccc21 10.1021/jm070055c
CHEMBL390539 151099 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 569 9 2 5 5.5 O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCOc2cc(CN3CCCC3)ccc21 10.1021/jm070055c
11071992 67099 0 None 3 2 Human 8.2 pKi = 8.2 Binding
Inhibition of human bradykinin B1 receptorInhibition of human bradykinin B1 receptor
ChEMBL 584 7 2 5 6.4 CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCC(N4CCCCC4)CC3)cc2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm034020y
CHEMBL1744082 67099 0 None 3 2 Human 8.2 pKi = 8.2 Binding
Inhibition of human bradykinin B1 receptorInhibition of human bradykinin B1 receptor
ChEMBL 584 7 2 5 6.4 CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCC(N4CCCCC4)CC3)cc2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm034020y
71229238 132721 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 522 6 2 9 2.8 Cn1nnc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)c3ccno3)CC2)n1 nan
CHEMBL3648503 132721 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 522 6 2 9 2.8 Cn1nnc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)c3ccno3)CC2)n1 nan
68868627 84306 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 484 12 0 7 1.0 COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCN(CCCN(C)C)CC2)c(C)c1 10.1021/jm2016057
CHEMBL2087427 84306 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 484 12 0 7 1.0 COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCN(CCCN(C)C)CC2)c(C)c1 10.1021/jm2016057
60142438 132685 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 536 5 2 5 5.0 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CCC3(C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 nan
CHEMBL3648467 132685 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 536 5 2 5 5.0 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CCC3(C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 nan
16221057 149798 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 607 11 3 5 5.6 CC(C)CNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1 10.1021/jm070055c
CHEMBL389478 149798 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 607 11 3 5 5.6 CC(C)CNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1 10.1021/jm070055c
3102216 194946 6 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration techniqueDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration technique
ChEMBL 493 6 2 5 4.2 COc1ccccc1NC(=O)CC1C(=O)Nc2ccccc2N1S(=O)(=O)c1c(C)cc(C)cc1C 10.1016/j.bmcl.2008.07.055
CHEMBL498679 194946 6 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration techniqueDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration technique
ChEMBL 493 6 2 5 4.2 COc1ccccc1NC(=O)CC1C(=O)Nc2ccccc2N1S(=O)(=O)c1c(C)cc(C)cc1C 10.1016/j.bmcl.2008.07.055
57382963 133982 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 557 7 2 9 3.1 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)C3(NC(=O)c4nccn4C)COC3)c(F)c2)no1 nan
CHEMBL3657633 133982 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 557 7 2 9 3.1 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)C3(NC(=O)c4nccn4C)COC3)c(F)c2)no1 nan
44455255 102210 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 335 5 2 4 2.0 COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)CO)c(F)c1 10.1016/j.bmcl.2007.11.050
CHEMBL257053 102210 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 335 5 2 4 2.0 COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)CO)c(F)c1 10.1016/j.bmcl.2007.11.050
44411153 148008 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 548 7 1 6 4.7 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(CC(F)(F)F)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
CHEMBL382909 148008 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 548 7 1 6 4.7 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(CC(F)(F)F)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
11553268 81170 0 None - 1 Human 4.3 pKi = 4.3 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 408 7 2 4 2.8 COC(=O)c1ccccc1-c1ccc(CNC(=O)CNC(=O)CC(F)(F)F)cc1 10.1021/jm0511280
CHEMBL202463 81170 0 None - 1 Human 4.3 pKi = 4.3 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 408 7 2 4 2.8 COC(=O)c1ccccc1-c1ccc(CNC(=O)CNC(=O)CC(F)(F)F)cc1 10.1021/jm0511280
60142169 132678 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 494 5 2 4 4.5 COC(=O)c1c(Cl)cccc1-c1ccc2c(c1)CCCC2NC(=O)C1(NC(=O)C(F)(F)F)CC1 nan
CHEMBL3648460 132678 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 494 5 2 4 4.5 COC(=O)c1c(Cl)cccc1-c1ccc2c(c1)CCCC2NC(=O)C1(NC(=O)C(F)(F)F)CC1 nan
44392133 72869 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity against Human bradykinin receptor B1Binding affinity against Human bradykinin receptor B1
ChEMBL 446 7 2 6 4.5 COC(=O)C1C2CCC(CC2)C1c1ccc(CNc2nccc(C)c2NC(=O)CC#N)cc1 10.1016/j.bmcl.2005.05.133
CHEMBL183876 72869 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity against Human bradykinin receptor B1Binding affinity against Human bradykinin receptor B1
ChEMBL 446 7 2 6 4.5 COC(=O)C1C2CCC(CC2)C1c1ccc(CNc2nccc(C)c2NC(=O)CC#N)cc1 10.1016/j.bmcl.2005.05.133
11555433 195768 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells
ChEMBL 520 8 3 6 3.0 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1cccc(Cl)c1 10.1016/j.bmcl.2008.07.108
CHEMBL508632 195768 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells
ChEMBL 520 8 3 6 3.0 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1cccc(Cl)c1 10.1016/j.bmcl.2008.07.108
10282203 195196 0 None - 1 Human 7.3 pKi = 7.3 Binding
Inhibition of human bradykinin B1 receptorInhibition of human bradykinin B1 receptor
ChEMBL 600 9 2 5 6.8 CCCN1C(=O)C(NC(=O)Nc2ccc(N3CCC(c4ccncc4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 10.1021/jm034020y
CHEMBL50208 195196 0 None - 1 Human 7.3 pKi = 7.3 Binding
Inhibition of human bradykinin B1 receptorInhibition of human bradykinin B1 receptor
ChEMBL 600 9 2 5 6.8 CCCN1C(=O)C(NC(=O)Nc2ccc(N3CCC(c4ccncc4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 10.1021/jm034020y
24895181 185731 3 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 430 6 2 4 4.0 CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccc(F)cc2F)cc1 10.1021/jm800199h
CHEMBL470486 185731 3 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 430 6 2 4 4.0 CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccc(F)cc2F)cc1 10.1021/jm800199h
11605512 180382 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells
ChEMBL 486 8 3 6 2.4 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1ccccc1 10.1016/j.bmcl.2008.07.108
CHEMBL453340 180382 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells
ChEMBL 486 8 3 6 2.4 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1ccccc1 10.1016/j.bmcl.2008.07.108
44587207 194927 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration techniqueDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration technique
ChEMBL 573 6 2 6 4.4 O=Cc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2008.07.055
CHEMBL498489 194927 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration techniqueDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration technique
ChEMBL 573 6 2 6 4.4 O=Cc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2008.07.055
44455074 162311 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 417 5 2 4 3.3 COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)[C@](C)(O)C(F)(F)F)c(F)c1 10.1016/j.bmcl.2007.11.050
CHEMBL404246 162311 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 417 5 2 4 3.3 COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)[C@](C)(O)C(F)(F)F)c(F)c1 10.1016/j.bmcl.2007.11.050
70688995 84227 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity to B1 receptorBinding affinity to B1 receptor
ChEMBL 611 14 5 6 2.9 Cc1c(Cl)ccc(S(=O)(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCCN)C(=O)NCC2CCNCC2)c1Cl 10.1021/jm2016057
CHEMBL2087029 84227 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity to B1 receptorBinding affinity to B1 receptor
ChEMBL 611 14 5 6 2.9 Cc1c(Cl)ccc(S(=O)(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCCN)C(=O)NCC2CCNCC2)c1Cl 10.1021/jm2016057
44455256 173853 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 361 5 2 4 2.6 COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)C2(O)CC2)c(F)c1 10.1016/j.bmcl.2007.11.050
CHEMBL428954 173853 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 361 5 2 4 2.6 COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)C2(O)CC2)c(F)c1 10.1016/j.bmcl.2007.11.050
11691896 193484 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells
ChEMBL 504 8 1 4 5.6 O=C(CCCS(=O)(=O)c1ccc2ccccc2c1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2008.07.108
CHEMBL488512 193484 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells
ChEMBL 504 8 1 4 5.6 O=C(CCCS(=O)(=O)c1ccc2ccccc2c1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 10.1016/j.bmcl.2008.07.108
60142961 132705 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 427 4 2 6 3.5 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(N)CC2)no1 nan
CHEMBL3648487 132705 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 427 4 2 6 3.5 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(N)CC2)no1 nan
11466010 91189 0 None 1 3 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]des-arg10, leu9-kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-arg10, leu9-kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 490 7 2 8 4.8 C[C@@H](Nc1nccc(Cl)c1NC(=O)CC#N)c1ccc(-c2cccc(F)c2-c2nnnn2C)cc1 10.1021/jm049394l
CHEMBL221984 91189 0 None 1 3 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]des-arg10, leu9-kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-arg10, leu9-kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 490 7 2 8 4.8 C[C@@H](Nc1nccc(Cl)c1NC(=O)CC#N)c1ccc(-c2cccc(F)c2-c2nnnn2C)cc1 10.1021/jm049394l
44402298 78411 0 None - 1 Human 8.2 pKi = 8.2 Binding
Inhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cellsInhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cells
ChEMBL 470 7 3 4 5.5 CNC(=O)c1ccccc1-c1ccc([C@@H](C)Nc2nccc(C)c2NC(=O)CC(F)(F)F)cc1 10.1016/j.bmcl.2005.02.077
CHEMBL196352 78411 0 None - 1 Human 8.2 pKi = 8.2 Binding
Inhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cellsInhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cells
ChEMBL 470 7 3 4 5.5 CNC(=O)c1ccccc1-c1ccc([C@@H](C)Nc2nccc(C)c2NC(=O)CC(F)(F)F)cc1 10.1016/j.bmcl.2005.02.077
60142028 132672 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 522 5 2 5 4.8 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 nan
CHEMBL3648455 132672 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 522 5 2 5 4.8 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 nan
60143096 132709 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 522 6 2 8 4.0 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)c3ccno3)CC2)no1 nan
CHEMBL3648491 132709 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 522 6 2 8 4.0 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)c3ccno3)CC2)no1 nan
60141323 132722 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 536 6 2 9 3.1 Cc1cc(C(=O)NC2(C(=O)NC3CCc4cc(-c5cc(Cl)cc(F)c5-c5nnn(C)n5)cnc43)CC2)on1 nan
CHEMBL3648504 132722 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 536 6 2 9 3.1 Cc1cc(C(=O)NC2(C(=O)NC3CCc4cc(-c5cc(Cl)cc(F)c5-c5nnn(C)n5)cnc43)CC2)on1 nan
70691812 80619 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 570 8 2 5 4.6 O=C(CC1CCc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)NCCc1ccc(C2=NCCN2)cc1 10.1016/j.bmcl.2012.03.065
CHEMBL2018859 80619 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 570 8 2 5 4.6 O=C(CC1CCc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)NCCc1ccc(C2=NCCN2)cc1 10.1016/j.bmcl.2012.03.065
11526655 193346 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells
ChEMBL 534 9 1 5 5.2 CO[C@@H](CC(=O)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)CS(=O)(=O)c1ccc2ccccc2c1 10.1016/j.bmcl.2008.07.108
CHEMBL487823 193346 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells
ChEMBL 534 9 1 5 5.2 CO[C@@H](CC(=O)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)CS(=O)(=O)c1ccc2ccccc2c1 10.1016/j.bmcl.2008.07.108
57382793 133963 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 502 6 2 5 3.6 COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)COC2)c(F)c1 nan
CHEMBL3657614 133963 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 502 6 2 5 3.6 COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)COC2)c(F)c1 nan
11953367 23843 19 None -19 2 Mouse 8.2 pKi = 8.2 Binding
Binding affinity to mouse bradykinin B1 receptorBinding affinity to mouse bradykinin B1 receptor
ChEMBL 502 11 1 7 2.0 COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N(C)Cc2ccc(C3=NCCN3)cc2)c(C)c1 10.1021/jm1000776
CHEMBL1254771 23843 19 None -19 2 Mouse 8.2 pKi = 8.2 Binding
Binding affinity to mouse bradykinin B1 receptorBinding affinity to mouse bradykinin B1 receptor
ChEMBL 502 11 1 7 2.0 COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N(C)Cc2ccc(C3=NCCN3)cc2)c(C)c1 10.1021/jm1000776
60142567 132690 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 540 5 2 7 3.8 Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)SCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)n1 nan
CHEMBL3648472 132690 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 540 5 2 7 3.8 Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)SCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)n1 nan
60142440 132686 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 536 5 2 6 3.8 Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CCC3(C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)n1 nan
CHEMBL3648468 132686 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 536 5 2 6 3.8 Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CCC3(C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)n1 nan
16221283 92307 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 609 12 3 6 4.9 COCCNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(Cl)c(Cl)c1)c1ccc(F)cc1 10.1021/jm070055c
CHEMBL227655 92307 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 609 12 3 6 4.9 COCCNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(Cl)c(Cl)c1)c1ccc(F)cc1 10.1021/jm070055c
57342852 84294 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 492 10 1 6 2.3 Cc1c(Cl)cccc1S(=O)(=O)N(C)CCOCC(=O)N(C)Cc1ccc(C2=NCCN2)cc1 10.1021/jm2016057
CHEMBL2087415 84294 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 492 10 1 6 2.3 Cc1c(Cl)cccc1S(=O)(=O)N(C)CCOCC(=O)N(C)Cc1ccc(C2=NCCN2)cc1 10.1021/jm2016057
44430683 94774 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity at human bradykinin B1 receptorBinding affinity at human bradykinin B1 receptor
ChEMBL 434 6 2 4 5.2 N#CC1(c2ccc(F)cc2)CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1 10.1016/j.bmcl.2007.03.059
CHEMBL234297 94774 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity at human bradykinin B1 receptorBinding affinity at human bradykinin B1 receptor
ChEMBL 434 6 2 4 5.2 N#CC1(c2ccc(F)cc2)CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1 10.1016/j.bmcl.2007.03.059
54585539 68974 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells membrane after 90 mins by scintillation countingDisplacement of [3H]-DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells membrane after 90 mins by scintillation counting
ChEMBL 470 6 3 5 1.5 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN)ccc32)cc1 10.1016/j.bmcl.2011.11.112
CHEMBL1777973 68974 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells membrane after 90 mins by scintillation countingDisplacement of [3H]-DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells membrane after 90 mins by scintillation counting
ChEMBL 470 6 3 5 1.5 Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN)ccc32)cc1 10.1016/j.bmcl.2011.11.112
44411338 145208 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 467 7 1 5 5.9 COC(=O)c1c(Cl)cccc1-c1ccc(CNc2cc(CN3CCCCC3)ccn2)c(F)c1 10.1016/j.bmcl.2006.01.112
CHEMBL377440 145208 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 467 7 1 5 5.9 COC(=O)c1c(Cl)cccc1-c1ccc(CNc2cc(CN3CCCCC3)ccn2)c(F)c1 10.1016/j.bmcl.2006.01.112
44411245 84070 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 542 7 1 6 5.4 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(c4ccccc4)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
CHEMBL208210 84070 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 542 7 1 6 5.4 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(c4ccccc4)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
16102922 91009 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 494 6 2 6 3.2 C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)CC1)c1ccc(-c2cccc(F)c2-c2nnnn2C)cc1F 10.1021/jm061094b
CHEMBL220978 91009 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cells
ChEMBL 494 6 2 6 3.2 C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)CC1)c1ccc(-c2cccc(F)c2-c2nnnn2C)cc1F 10.1021/jm061094b
70691813 80195 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 640 7 1 5 7.0 O=C(CC1CCc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)Nc1ccc(N2CCC(N3CCCCC3)CC2)cc1 10.1016/j.bmcl.2012.03.065
CHEMBL2016601 80195 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 640 7 1 5 7.0 O=C(CC1CCc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)Nc1ccc(N2CCC(N3CCCCC3)CC2)cc1 10.1016/j.bmcl.2012.03.065
11546560 80711 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 434 7 2 4 3.4 COC(=O)c1ccccc1-c1ccc(CNC(=O)C2(NC(=O)CC(F)(F)F)CC2)cc1 10.1021/jm0511280
CHEMBL202089 80711 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 434 7 2 4 3.4 COC(=O)c1ccccc1-c1ccc(CNC(=O)C2(NC(=O)CC(F)(F)F)CC2)cc1 10.1021/jm0511280
60141183 132718 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 527 5 2 8 3.9 Cn1nnc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)OC(C)(C)C)CC2)n1 nan
CHEMBL3648500 132718 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 527 5 2 8 3.9 Cn1nnc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)OC(C)(C)C)CC2)n1 nan
12085225 84293 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 469 10 1 7 1.2 CN(Cc1ccc(C2=NCCN2)cc1)C(=O)COCCN(C)S(=O)(=O)c1ccccc1C#N 10.1021/jm2016057
CHEMBL2087414 84293 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 469 10 1 7 1.2 CN(Cc1ccc(C2=NCCN2)cc1)C(=O)COCCN(C)S(=O)(=O)c1ccccc1C#N 10.1021/jm2016057
56594373 72657 0 None - 1 Human 5.2 pKi = 5.2 Binding
Binding affinity to human B1 bradykinin receptorBinding affinity to human B1 bradykinin receptor
ChEMBL 506 5 1 5 5.5 Cc1nn(-c2cccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)c2)c(=O)c2ccccc12 10.1016/j.bmcl.2011.10.068
CHEMBL1835762 72657 0 None - 1 Human 5.2 pKi = 5.2 Binding
Binding affinity to human B1 bradykinin receptorBinding affinity to human B1 bradykinin receptor
ChEMBL 506 5 1 5 5.5 Cc1nn(-c2cccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)c2)c(=O)c2ccccc12 10.1016/j.bmcl.2011.10.068
56594241 72651 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity to human B1 bradykinin receptorBinding affinity to human B1 bradykinin receptor
ChEMBL 492 5 1 4 6.3 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3ccccc3c2=O)c1 10.1016/j.bmcl.2011.10.068
CHEMBL1835756 72651 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity to human B1 bradykinin receptorBinding affinity to human B1 bradykinin receptor
ChEMBL 492 5 1 4 6.3 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3ccccc3c2=O)c1 10.1016/j.bmcl.2011.10.068
44411252 83665 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 543 7 1 7 4.8 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(c4ccccn4)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
CHEMBL207011 83665 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 543 7 1 7 4.8 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(c4ccccn4)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
24895112 183500 3 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 412 6 2 4 3.8 CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2cccc(F)c2)cc1 10.1021/jm800199h
CHEMBL460046 183500 3 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 412 6 2 4 3.8 CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2cccc(F)c2)cc1 10.1021/jm800199h
12085129 84230 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 510 9 1 5 3.7 Cc1c(Cl)ccc(S(=O)(=O)N(C)CCCC(=O)N(C)Cc2ccc(C3=NCCN3)cc2)c1Cl 10.1021/jm2016057
CHEMBL2087033 84230 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 510 9 1 5 3.7 Cc1c(Cl)ccc(S(=O)(=O)N(C)CCCC(=O)N(C)Cc2ccc(C3=NCCN3)cc2)c1Cl 10.1021/jm2016057
44455181 104215 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 349 5 2 4 2.4 COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)[C@H](C)O)c(F)c1 10.1016/j.bmcl.2007.11.050
CHEMBL270017 104215 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 349 5 2 4 2.4 COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)[C@H](C)O)c(F)c1 10.1016/j.bmcl.2007.11.050
60142568 132691 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 526 5 2 6 5.7 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)OC(C)(C)C)CC2)no1 nan
CHEMBL3648473 132691 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 526 5 2 6 5.7 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)OC(C)(C)C)CC2)no1 nan
24970501 194911 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]Lys-bradykinin from human recombinant bradykinin B1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]Lys-bradykinin from human recombinant bradykinin B1 receptor expressed in CHO cells by scintillation counting
ChEMBL 516 8 2 5 3.4 Cc1ccc(S(=O)(=O)N2CCc3ccccc3C2CC(=O)NCCc2ccc(C3=NCCN3)cc2)cc1 10.1016/j.ejmech.2007.10.030
CHEMBL498394 194911 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]Lys-bradykinin from human recombinant bradykinin B1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]Lys-bradykinin from human recombinant bradykinin B1 receptor expressed in CHO cells by scintillation counting
ChEMBL 516 8 2 5 3.4 Cc1ccc(S(=O)(=O)N2CCc3ccccc3C2CC(=O)NCCc2ccc(C3=NCCN3)cc2)cc1 10.1016/j.ejmech.2007.10.030
11281533 71851 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity against Human bradykinin receptor B1Binding affinity against Human bradykinin receptor B1
ChEMBL 418 7 2 6 4.1 COC(=O)C1CC=CCC1c1ccc(CNc2nccc(C)c2NC(=O)CC#N)cc1 10.1016/j.bmcl.2005.05.133
CHEMBL182378 71851 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity against Human bradykinin receptor B1Binding affinity against Human bradykinin receptor B1
ChEMBL 418 7 2 6 4.1 COC(=O)C1CC=CCC1c1ccc(CNc2nccc(C)c2NC(=O)CC#N)cc1 10.1016/j.bmcl.2005.05.133
60141465 132727 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 539 6 2 9 3.6 Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)SCC3NC(=O)C2(NC(=O)c3ccno3)CC2)n1 nan
CHEMBL3648509 132727 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 539 6 2 9 3.6 Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)SCC3NC(=O)C2(NC(=O)c3ccno3)CC2)n1 nan
57383096 133997 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 589 9 2 8 4.4 Cc1nnsc1C(=O)NC1(C(=O)N[C@H](C)c2ncc(-c3cc(Cl)cc(Cl)c3OCC(F)F)cc2F)COC1 nan
CHEMBL3657648 133997 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 589 9 2 8 4.4 Cc1nnsc1C(=O)NC1(C(=O)N[C@H](C)c2ncc(-c3cc(Cl)cc(Cl)c3OCC(F)F)cc2F)COC1 nan
71456247 85782 0 None - 1 Human 8.2 pKi = 8.2 Binding
Inhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cellsInhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cells
ChEMBL 457 7 2 5 5.3 COC(=O)c1ccccc1-c1ccc(CNc2nccc(C)c2NC(=O)CC(F)(F)F)cc1 10.1016/j.bmcl.2005.02.077
CHEMBL2113085 85782 0 None - 1 Human 8.2 pKi = 8.2 Binding
Inhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cellsInhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cells
ChEMBL 457 7 2 5 5.3 COC(=O)c1ccccc1-c1ccc(CNc2nccc(C)c2NC(=O)CC(F)(F)F)cc1 10.1016/j.bmcl.2005.02.077
16102897 94014 17 None -7 3 Rabbit 8.1 pKi = 8.1 Binding
Binding affinity to rabbit bradykinin B1 receptorBinding affinity to rabbit bradykinin B1 receptor
ChEMBL 486 6 2 4 4.3 COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1021/jm061094b
CHEMBL232943 94014 17 None -7 3 Rabbit 8.1 pKi = 8.1 Binding
Binding affinity to rabbit bradykinin B1 receptorBinding affinity to rabbit bradykinin B1 receptor
ChEMBL 486 6 2 4 4.3 COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 10.1021/jm061094b
60142963 132707 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 533 6 2 8 3.8 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)c3ccnnc3)CC2)no1 nan
CHEMBL3648489 132707 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 533 6 2 8 3.8 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)c3ccnnc3)CC2)no1 nan
44432178 94172 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 510 6 2 5 4.9 Cc1noc(-c2ccc(Cl)cc2-c2ccc([C@@H](C)NC(=O)C3(NC(=O)C(F)(F)F)CC3)c(F)c2)n1 10.1016/j.bmcl.2007.04.040
CHEMBL233350 94172 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 510 6 2 5 4.9 Cc1noc(-c2ccc(Cl)cc2-c2ccc([C@@H](C)NC(=O)C3(NC(=O)C(F)(F)F)CC3)c(F)c2)n1 10.1016/j.bmcl.2007.04.040
16220990 92321 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 589 9 3 5 5.9 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(Cl)c(Cl)c1)c1ccccc1 10.1021/jm070055c
CHEMBL227786 92321 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 589 9 3 5 5.9 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(Cl)c(Cl)c1)c1ccccc1 10.1021/jm070055c
659 9673 17 None 1 2 Rhesus macaque 8.1 pKi = 8.1 Binding
Binding affinity to monkey bradykinin B1 receptorBinding affinity to monkey bradykinin B1 receptor
ChEMBL 659 9 1 7 3.6 CN1CCN(CC1)C(=O)C1CCN(CC1)S(=O)(=O)c1ccc(c(c1)C(=O)N1CCOCC1)NCC(c1ccccc1)c1ccccc1 10.1021/jm1000776
9831083 9673 17 None 1 2 Rhesus macaque 8.1 pKi = 8.1 Binding
Binding affinity to monkey bradykinin B1 receptorBinding affinity to monkey bradykinin B1 receptor
ChEMBL 659 9 1 7 3.6 CN1CCN(CC1)C(=O)C1CCN(CC1)S(=O)(=O)c1ccc(c(c1)C(=O)N1CCOCC1)NCC(c1ccccc1)c1ccccc1 10.1021/jm1000776
CHEMBL273869 9673 17 None 1 2 Rhesus macaque 8.1 pKi = 8.1 Binding
Binding affinity to monkey bradykinin B1 receptorBinding affinity to monkey bradykinin B1 receptor
ChEMBL 659 9 1 7 3.6 CN1CCN(CC1)C(=O)C1CCN(CC1)S(=O)(=O)c1ccc(c(c1)C(=O)N1CCOCC1)NCC(c1ccccc1)c1ccccc1 10.1021/jm1000776
44411091 83877 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 465 6 1 5 5.1 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCCCC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
CHEMBL207539 83877 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 465 6 1 5 5.1 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCCCC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
24895352 185963 3 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 428 6 2 4 4.3 CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccc(Cl)cc2)cc1 10.1021/jm800199h
CHEMBL472303 185963 3 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 428 6 2 4 4.3 CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccc(Cl)cc2)cc1 10.1021/jm800199h
44455148 104194 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 377 6 2 4 3.1 COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)[C@@H](O)C(C)C)c(F)c1 10.1016/j.bmcl.2007.11.050
CHEMBL269948 104194 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 377 6 2 4 3.1 COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)[C@@H](O)C(C)C)c(F)c1 10.1016/j.bmcl.2007.11.050
24895183 195074 3 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 395 6 2 5 3.1 CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2cccnc2)cc1 10.1021/jm800199h
CHEMBL500312 195074 3 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 395 6 2 5 3.1 CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2cccnc2)cc1 10.1021/jm800199h
44411252 83665 0 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity to human BK1 receptor N298 mutantBinding affinity to human BK1 receptor N298 mutant
ChEMBL 543 7 1 7 4.8 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(c4ccccn4)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
CHEMBL207011 83665 0 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity to human BK1 receptor N298 mutantBinding affinity to human BK1 receptor N298 mutant
ChEMBL 543 7 1 7 4.8 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(c4ccccn4)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
11375297 99347 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]DAKA from human bradykinin B1 receptor in IL1-beta stimulated IMR90 cellsDisplacement of [3H]DAKA from human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells
ChEMBL 490 6 3 5 3.7 COC(=O)[C@@H](NC(=O)c1n[nH]c(NC(=O)c2ccccc2Cl)c1Br)c1ccccc1 10.1021/jm051292n
CHEMBL243467 99347 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]DAKA from human bradykinin B1 receptor in IL1-beta stimulated IMR90 cellsDisplacement of [3H]DAKA from human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells
ChEMBL 490 6 3 5 3.7 COC(=O)[C@@H](NC(=O)c1n[nH]c(NC(=O)c2ccccc2Cl)c1Br)c1ccccc1 10.1021/jm051292n
44392113 72640 0 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity against Human bradykinin receptor B1Binding affinity against Human bradykinin receptor B1
ChEMBL 432 7 2 6 4.2 COC(=O)C1C2CCC(C2)C1c1ccc(CNc2nccc(C)c2NC(=O)CC#N)cc1 10.1016/j.bmcl.2005.05.133
CHEMBL183562 72640 0 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity against Human bradykinin receptor B1Binding affinity against Human bradykinin receptor B1
ChEMBL 432 7 2 6 4.2 COC(=O)C1C2CCC(C2)C1c1ccc(CNc2nccc(C)c2NC(=O)CC#N)cc1 10.1016/j.bmcl.2005.05.133
11670114 79864 0 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 476 7 2 4 4.5 COC(=O)c1ccccc1-c1ccc(CNC(=O)C2(NC(=O)CC(F)(F)F)CCCCC2)cc1 10.1021/jm0511280
CHEMBL201107 79864 0 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 476 7 2 4 4.5 COC(=O)c1ccccc1-c1ccc(CNC(=O)C2(NC(=O)CC(F)(F)F)CCCCC2)cc1 10.1021/jm0511280
57390933 76334 0 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity to human B1 bradykinin receptorBinding affinity to human B1 bradykinin receptor
ChEMBL 526 5 1 4 6.9 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3ccc(Cl)cc3c2=O)c1 10.1016/j.bmcl.2011.10.068
CHEMBL1934255 76334 0 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity to human B1 bradykinin receptorBinding affinity to human B1 bradykinin receptor
ChEMBL 526 5 1 4 6.9 O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3ccc(Cl)cc3c2=O)c1 10.1016/j.bmcl.2011.10.068
16220989 149277 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 589 9 3 5 5.6 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(C(F)(F)F)cc1)c1ccccc1 10.1021/jm070055c
CHEMBL389054 149277 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 589 9 3 5 5.6 CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(C(F)(F)F)cc1)c1ccccc1 10.1021/jm070055c
49863231 21998 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptorDisplacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptor
ChEMBL 585 10 2 4 5.9 C=C(CN(C)C)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2010.06.010
CHEMBL1210748 21998 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptorDisplacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptor
ChEMBL 585 10 2 4 5.9 C=C(CN(C)C)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2010.06.010
10187167 84315 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 539 9 2 6 2.0 Cc1c(Cl)ccc(S(=O)(=O)N(C)CC(=O)NCC(=O)N(C)Cc2ccc(C3=NCCN3)cc2)c1Cl 10.1021/jm2016057
CHEMBL2087436 84315 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 539 9 2 6 2.0 Cc1c(Cl)ccc(S(=O)(=O)N(C)CC(=O)NCC(=O)N(C)Cc2ccc(C3=NCCN3)cc2)c1Cl 10.1021/jm2016057
44411372 84076 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 506 8 1 6 4.4 C=CCN1CCN(C(=O)c2ccc(NCc3ccc(-c4cccc(F)c4C(=O)OC)cc3F)nc2)CC1 10.1016/j.bmcl.2006.01.112
CHEMBL208241 84076 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 506 8 1 6 4.4 C=CCN1CCN(C(=O)c2ccc(NCc3ccc(-c4cccc(F)c4C(=O)OC)cc3F)nc2)CC1 10.1016/j.bmcl.2006.01.112
659 9673 17 None -1 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]Lys0-des-Arg9-BK at human bradykinin B1 receptor expressed in HEK293 cellsDisplacement of [3H]Lys0-des-Arg9-BK at human bradykinin B1 receptor expressed in HEK293 cells
ChEMBL 659 9 1 7 3.6 CN1CCN(CC1)C(=O)C1CCN(CC1)S(=O)(=O)c1ccc(c(c1)C(=O)N1CCOCC1)NCC(c1ccccc1)c1ccccc1 10.1021/jm1000776
9831083 9673 17 None -1 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]Lys0-des-Arg9-BK at human bradykinin B1 receptor expressed in HEK293 cellsDisplacement of [3H]Lys0-des-Arg9-BK at human bradykinin B1 receptor expressed in HEK293 cells
ChEMBL 659 9 1 7 3.6 CN1CCN(CC1)C(=O)C1CCN(CC1)S(=O)(=O)c1ccc(c(c1)C(=O)N1CCOCC1)NCC(c1ccccc1)c1ccccc1 10.1021/jm1000776
CHEMBL273869 9673 17 None -1 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]Lys0-des-Arg9-BK at human bradykinin B1 receptor expressed in HEK293 cellsDisplacement of [3H]Lys0-des-Arg9-BK at human bradykinin B1 receptor expressed in HEK293 cells
ChEMBL 659 9 1 7 3.6 CN1CCN(CC1)C(=O)C1CCN(CC1)S(=O)(=O)c1ccc(c(c1)C(=O)N1CCOCC1)NCC(c1ccccc1)c1ccccc1 10.1021/jm1000776
16220915 92309 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 557 10 3 5 5.4 CC(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 10.1021/jm070055c
CHEMBL227690 92309 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 557 10 3 5 5.4 CC(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 10.1021/jm070055c
57383056 133995 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 573 9 2 8 3.9 Cc1nnc(C(=O)NC2(C(=O)N[C@H](C)c3ncc(-c4cc(Cl)cc(Cl)c4OCC(F)F)cc3F)COC2)o1 nan
CHEMBL3657646 133995 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 573 9 2 8 3.9 Cc1nnc(C(=O)NC2(C(=O)N[C@H](C)c3ncc(-c4cc(Cl)cc(Cl)c4OCC(F)F)cc3F)COC2)o1 nan
23627583 80634 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 655 9 1 5 7.5 COc1cccc2c1-c1ccccc1N(S(=O)(=O)c1ccc(Cl)c(Cl)c1)C2CC(=O)N[C@H]1CC[C@H](CCN2CCCC2)CC1 10.1016/j.bmcl.2012.03.065
CHEMBL2018874 80634 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 655 9 1 5 7.5 COc1cccc2c1-c1ccccc1N(S(=O)(=O)c1ccc(Cl)c(Cl)c1)C2CC(=O)N[C@H]1CC[C@H](CCN2CCCC2)CC1 10.1016/j.bmcl.2012.03.065
16221110 91810 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 543 10 3 5 5.0 CCNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 10.1021/jm070055c
CHEMBL224071 91810 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 543 10 3 5 5.0 CCNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 10.1021/jm070055c
44411092 83811 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 467 6 1 6 3.9 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCOCC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
CHEMBL207178 83811 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 467 6 1 6 3.9 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCOCC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
11363856 91310 0 None -162 3 Rat 7.1 pKi = 7.1 Binding
Displacement of [3H]des-arg10 kallidin from rat bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-arg10 kallidin from rat bradykinin B1 receptor expressed in CHO cells
ChEMBL 490 7 2 7 5.9 Cc1noc(-c2c(F)cccc2-c2ccc([C@@H](C)Nc3nccc(Cl)c3NC(=O)CC#N)cc2)n1 10.1021/jm049394l
CHEMBL222038 91310 0 None -162 3 Rat 7.1 pKi = 7.1 Binding
Displacement of [3H]des-arg10 kallidin from rat bradykinin B1 receptor expressed in CHO cellsDisplacement of [3H]des-arg10 kallidin from rat bradykinin B1 receptor expressed in CHO cells
ChEMBL 490 7 2 7 5.9 Cc1noc(-c2c(F)cccc2-c2ccc([C@@H](C)Nc3nccc(Cl)c3NC(=O)CC#N)cc2)n1 10.1021/jm049394l
44411297 84136 0 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 354 5 1 4 4.4 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccccn2)c(F)c1 10.1016/j.bmcl.2006.01.112
CHEMBL208538 84136 0 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 354 5 1 4 4.4 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccccn2)c(F)c1 10.1016/j.bmcl.2006.01.112
57382964 133983 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 557 7 2 9 3.1 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)C3(NC(=O)c4cn(C)cn4)COC3)c(F)c2)no1 nan
CHEMBL3657634 133983 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.Binding Assay: For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kallidin (Des Arg10, Leu9), [3,4-Prolyl-3,4-3H(N)] (PerkinElmer, 1.85-4.44 TBq/mmol) to 40 μg membrane protein containing approximately 1 fmol Bradykinin-1 receptor and incubated for 15 min at 27° C. To determine non-specific binding 10 μM Lys-(Des-Arg9)-Bradykinin (Bachem) was added. Membranes were harvested through GF/B (glass fiber filter; PerkinElmer) plates, equilibrated with 0.5% polyethylenimine, air dried at 50° C. for 2 hr. Radioactivity was determined by counting in a topcounter (NXT Packard). Specific binding was defined as total binding minus nonspecific binding and typically represents about 90-95% of the total binding. Antagonist activity is expressed as Ki: inhibitor concentration required for 50% inhibition of specific binding corrected for the concentration of the radioligand.
ChEMBL 557 7 2 9 3.1 Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)C3(NC(=O)c4cn(C)cn4)COC3)c(F)c2)no1 nan
44316620 8902 0 None -19 2 Human 7.1 pKi = 7.1 Binding
Ability to bind to human cloned B1 receptor in competition binding experiments with [3H][des-Arg10,Leu9]-Kallidin.Ability to bind to human cloned B1 receptor in competition binding experiments with [3H][des-Arg10,Leu9]-Kallidin.
ChEMBL None None None None 10.1021/jm990961s
656 8902 0 None -19 2 Human 7.1 pKi = 7.1 Binding
Ability to bind to human cloned B1 receptor in competition binding experiments with [3H][des-Arg10,Leu9]-Kallidin.Ability to bind to human cloned B1 receptor in competition binding experiments with [3H][des-Arg10,Leu9]-Kallidin.
ChEMBL None None None None 10.1021/jm990961s
CHEMBL408846 8902 0 None -19 2 Human 7.1 pKi = 7.1 Binding
Ability to bind to human cloned B1 receptor in competition binding experiments with [3H][des-Arg10,Leu9]-Kallidin.Ability to bind to human cloned B1 receptor in competition binding experiments with [3H][des-Arg10,Leu9]-Kallidin.
ChEMBL None None None None 10.1021/jm990961s
44455107 104770 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 391 6 2 4 3.4 COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)[C@@](C)(O)C(C)C)c(F)c1 10.1016/j.bmcl.2007.11.050
CHEMBL272791 104770 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 391 6 2 4 3.4 COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)[C@@](C)(O)C(C)C)c(F)c1 10.1016/j.bmcl.2007.11.050
16220917 173114 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 543 9 2 5 5.0 CN(C)Cc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 10.1021/jm070055c
CHEMBL427279 173114 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
ChEMBL 543 9 2 5 5.0 CN(C)Cc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 10.1021/jm070055c
44411252 83665 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity to human BK1 receptor D291 mutantBinding affinity to human BK1 receptor D291 mutant
ChEMBL 543 7 1 7 4.8 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(c4ccccn4)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
CHEMBL207011 83665 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity to human BK1 receptor D291 mutantBinding affinity to human BK1 receptor D291 mutant
ChEMBL 543 7 1 7 4.8 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(c4ccccn4)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
12085227 84296 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 528 11 1 7 2.2 CN(Cc1ccc(C2=NCCN2)cc1)C(=O)COCCN(C)S(=O)(=O)c1ccc(OC(F)(F)F)cc1 10.1021/jm2016057
CHEMBL2087417 84296 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 528 11 1 7 2.2 CN(Cc1ccc(C2=NCCN2)cc1)C(=O)COCCN(C)S(=O)(=O)c1ccc(OC(F)(F)F)cc1 10.1021/jm2016057
10281725 7766 0 None -7 2 Human 7.1 pKi = 7.1 Binding
Inhibition of human bradykinin B1 receptorInhibition of human bradykinin B1 receptor
ChEMBL 579 7 2 6 5.7 CCCN1C(=O)C(NC(=O)Nc2ccc(cc2)N2CCN(CC2)c2cccnc2)N=C(c2c1cccc2)C1CCCCC1 10.1021/jm034020y
666 7766 0 None -7 2 Human 7.1 pKi = 7.1 Binding
Inhibition of human bradykinin B1 receptorInhibition of human bradykinin B1 receptor
ChEMBL 579 7 2 6 5.7 CCCN1C(=O)C(NC(=O)Nc2ccc(cc2)N2CCN(CC2)c2cccnc2)N=C(c2c1cccc2)C1CCCCC1 10.1021/jm034020y
CHEMBL299164 7766 0 None -7 2 Human 7.1 pKi = 7.1 Binding
Inhibition of human bradykinin B1 receptorInhibition of human bradykinin B1 receptor
ChEMBL 579 7 2 6 5.7 CCCN1C(=O)C(NC(=O)Nc2ccc(cc2)N2CCN(CC2)c2cccnc2)N=C(c2c1cccc2)C1CCCCC1 10.1021/jm034020y
44587206 194926 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration techniqueDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration technique
ChEMBL 575 6 3 6 4.0 O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)N[C@@H]1CCOc2cc(CO)ccc21 10.1016/j.bmcl.2008.07.055
CHEMBL498488 194926 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration techniqueDisplacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration technique
ChEMBL 575 6 3 6 4.0 O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)N[C@@H]1CCOc2cc(CO)ccc21 10.1016/j.bmcl.2008.07.055
44402279 77953 0 None - 1 Human 7.1 pKi = 7.1 Binding
Inhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cellsInhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cells
ChEMBL 403 8 2 5 4.9 CCCC(=O)Nc1cccnc1NCc1ccc(-c2ccccc2C(=O)OC)cc1 10.1016/j.bmcl.2005.02.077
CHEMBL195617 77953 0 None - 1 Human 7.1 pKi = 7.1 Binding
Inhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cellsInhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cells
ChEMBL 403 8 2 5 4.9 CCCC(=O)Nc1cccnc1NCc1ccc(-c2ccccc2C(=O)OC)cc1 10.1016/j.bmcl.2005.02.077
44455145 104688 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 391 5 2 4 3.4 COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)[C@@H](O)C(C)(C)C)c(F)c1 10.1016/j.bmcl.2007.11.050
CHEMBL272491 104688 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 391 5 2 4 3.4 COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)[C@@H](O)C(C)(C)C)c(F)c1 10.1016/j.bmcl.2007.11.050
44411134 84077 0 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 480 6 1 6 3.8 COC(=O)c1c(F)cccc1-c1ccc(CNc2cc(C(=O)N3CCN(C)CC3)ccn2)c(F)c1 10.1016/j.bmcl.2006.01.112
CHEMBL208247 84077 0 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 480 6 1 6 3.8 COC(=O)c1c(F)cccc1-c1ccc(CNc2cc(C(=O)N3CCN(C)CC3)ccn2)c(F)c1 10.1016/j.bmcl.2006.01.112
44411135 84078 0 None - 1 Human 8.0 pKi = 8.0 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 451 7 1 5 5.4 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(CN3CCCCC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
CHEMBL208248 84078 0 None - 1 Human 8.0 pKi = 8.0 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 451 7 1 5 5.4 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(CN3CCCCC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
23627523 80632 0 None - 1 Human 8.0 pKi = 8.0 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 654 8 2 5 6.3 O=C(CC1c2cc(F)cc(F)c2-c2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)NCCc1ccc(C2=NCCN2)cc1 10.1016/j.bmcl.2012.03.065
CHEMBL2018872 80632 0 None - 1 Human 8.0 pKi = 8.0 Binding
Binding affinity to human bradykinin B1 receptorBinding affinity to human bradykinin B1 receptor
ChEMBL 654 8 2 5 6.3 O=C(CC1c2cc(F)cc(F)c2-c2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)NCCc1ccc(C2=NCCN2)cc1 10.1016/j.bmcl.2012.03.065
60142304 132681 0 None - 1 Human 8.0 pKi = 8.0 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 523 5 2 7 3.0 Cn1nnc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)n1 nan
CHEMBL3648463 132681 0 None - 1 Human 8.0 pKi = 8.0 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 523 5 2 7 3.0 Cn1nnc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)n1 nan
60142441 132689 0 None - 1 Human 8.0 pKi = 8.0 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 540 5 2 6 5.0 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)SCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 nan
CHEMBL3648471 132689 0 None - 1 Human 8.0 pKi = 8.0 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 540 5 2 6 5.0 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)SCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 nan
60142705 132697 0 None - 1 Human 8.0 pKi = 8.0 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 536 6 2 8 4.3 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)c3nnc(C)o3)CC2)no1 nan
CHEMBL3648479 132697 0 None - 1 Human 8.0 pKi = 8.0 Binding
Binding Assay: Binding assay using Bradykinin-1 receptor.Binding Assay: Binding assay using Bradykinin-1 receptor.
ChEMBL 536 6 2 8 4.3 Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)c3nnc(C)o3)CC2)no1 nan
44411058 83972 0 None - 1 Human 8.0 pKi = 8.0 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 536 9 1 6 5.2 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(CCC(C)C)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
CHEMBL207913 83972 0 None - 1 Human 8.0 pKi = 8.0 Binding
Binding affinity to human BK1 receptorBinding affinity to human BK1 receptor
ChEMBL 536 9 1 6 5.2 COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(CCC(C)C)CC3)cn2)c(F)c1 10.1016/j.bmcl.2006.01.112
11752335 84310 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 496 9 0 7 1.2 COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCC(N3CCN(C)CC3)CC2)c(C)c1 10.1021/jm2016057
CHEMBL2087431 84310 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counterDisplacement of [3H]des-Arg10-KD from human recombinant B1 receptor expressed in HEK293 cells by liquid scintillation counter
ChEMBL 496 9 0 7 1.2 COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCC(N3CCN(C)CC3)CC2)c(C)c1 10.1021/jm2016057
25181411 196072 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]desArg from human B1 in human WI 38 cellsDisplacement of [3H]desArg from human B1 in human WI 38 cells
ChEMBL 587 14 1 6 5.0 COc1cc(CN(CC(=O)NCc2ccccc2Cl)S(=O)(=O)c2ccc(CN(C)C)cc2)ccc1OCC(C)C 10.1016/j.bmcl.2008.11.005
CHEMBL512111 196072 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]desArg from human B1 in human WI 38 cellsDisplacement of [3H]desArg from human B1 in human WI 38 cells
ChEMBL 587 14 1 6 5.0 COc1cc(CN(CC(=O)NCc2ccccc2Cl)S(=O)(=O)c2ccc(CN(C)C)cc2)ccc1OCC(C)C 10.1016/j.bmcl.2008.11.005
44455228 102198 0 None - 1 Human 7.0 pKi = 7.0 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 471 5 2 4 3.9 COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)C(O)(C(F)(F)F)C(F)(F)F)c(F)c1 10.1016/j.bmcl.2007.11.050
CHEMBL257016 102198 0 None - 1 Human 7.0 pKi = 7.0 Binding
Binding affinity to human bradykinin B1 receptor expressed in CHO cellsBinding affinity to human bradykinin B1 receptor expressed in CHO cells
ChEMBL 471 5 2 4 3.9 COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)C(O)(C(F)(F)F)C(F)(F)F)c(F)c1 10.1016/j.bmcl.2007.11.050
10120979 108391 0 None - 1 Human 7.0 pKi = 7.0 Binding
Inhibition of human bradykinin B1 receptorInhibition of human bradykinin B1 receptor
ChEMBL 579 7 2 6 5.7 CCCN1C(=O)C(NC(=O)Nc2ccc(N3CCN(c4ccccn4)CC3)cc2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm034020y
CHEMBL298860 108391 0 None - 1 Human 7.0 pKi = 7.0 Binding
Inhibition of human bradykinin B1 receptorInhibition of human bradykinin B1 receptor
ChEMBL 579 7 2 6 5.7 CCCN1C(=O)C(NC(=O)Nc2ccc(N3CCN(c4ccccn4)CC3)cc2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm034020y
122227 8160 31 None 6 3 Human 9.4 pKd None 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None None
3825 8160 31 None 6 3 Human 9.4 pKd None 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None None
644 8160 31 None 6 3 Human 9.4 pKd None 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None None
CHEMBL264100 8160 31 None 6 3 Human 9.4 pKd None 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None None
119376 8622 48 3H-BRADYKININ -54954 27 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 393 7 1 6 1.6 O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C None
247 8622 48 3H-BRADYKININ -54954 27 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 393 7 1 6 1.6 O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C None
CHEMBL33884 8622 48 3H-BRADYKININ -54954 27 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 393 7 1 6 1.6 O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C None
44208932 147485 7 UNDEFINED -89125 37 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 475 5 1 3 6.8 Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1 None
CHEMBL381689 147485 7 UNDEFINED -89125 37 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 475 5 1 3 6.8 Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1 None
None 222907 0 3H-BRADYKININ -1 13 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 164 3 1 3 0.8 C1CNC1COC2=CN=CC=C2 None
122173054 224513 0 None 1 6 Rat 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 1304 30 18 17 -4.4 N[C@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](CC1=CC=CS1)C(=O)N[C@@H](CO)C(=O)N1CC2=C(C[C@@H]1C(=O)N1[C@H]3CCCC[C@H]3C[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C=CC=C2 None
122173054 224513 0 None -1 6 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 1304 30 18 17 -4.4 N[C@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](CC1=CC=CS1)C(=O)N[C@@H](CO)C(=O)N1CC2=C(C[C@@H]1C(=O)N1[C@H]3CCCC[C@H]3C[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C=CC=C2 None
3812 7504 42 None -309029 6 Human 4.0 pKi = 4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9111052
439201 7504 42 None -309029 6 Human 4.0 pKi = 4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9111052
649 7504 42 None -309029 6 Human 4.0 pKi = 4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9111052
CHEMBL406291 7504 42 None -309029 6 Human 4.0 pKi = 4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9111052
DB12126 7504 42 None -309029 6 Human 4.0 pKi = 4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9111052
123643 10607 0 None -1 2 Rat 5.1 pKi = 5.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10422787
639 10607 0 None -1 2 Rat 5.1 pKi = 5.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10422787
3812 7504 42 None -19498 6 Rat 5.2 pKi = 5.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10422787
439201 7504 42 None -19498 6 Rat 5.2 pKi = 5.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10422787
649 7504 42 None -19498 6 Rat 5.2 pKi = 5.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10422787
CHEMBL406291 7504 42 None -19498 6 Rat 5.2 pKi = 5.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10422787
DB12126 7504 42 None -19498 6 Rat 5.2 pKi = 5.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10422787
123643 10607 0 None 1 2 Human 5.2 pKi = 5.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10422787
639 10607 0 None 1 2 Human 5.2 pKi = 5.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10422787
164234 10251 0 None -35 2 Human 5.7 pKi = 5.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10422787
164234 10251 0 None -35 2 Human 5.7 pKi = 5.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8996175
643 10251 0 None -35 2 Human 5.7 pKi = 5.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10422787
643 10251 0 None -35 2 Human 5.7 pKi = 5.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8996175
5311111 8956 0 None -44 3 Mouse 6.3 pKi = 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8302267
5311111 8956 0 None -44 3 Mouse 6.3 pKi = 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8856107
650 8956 0 None -44 3 Mouse 6.3 pKi = 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8302267
650 8956 0 None -44 3 Mouse 6.3 pKi = 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8856107
5311111 8956 0 None -25 3 Rat 6.6 pKi = 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10422787
650 8956 0 None -25 3 Rat 6.6 pKi = 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10422787
3812 7504 42 None -616 6 Mouse 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8856107
439201 7504 42 None -616 6 Mouse 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8856107
649 7504 42 None -616 6 Mouse 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8856107
CHEMBL406291 7504 42 None -616 6 Mouse 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8856107
DB12126 7504 42 None -616 6 Mouse 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8856107
122227 8160 31 None -6 3 Rat 8.8 pKi = 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10422787
3825 8160 31 None -6 3 Rat 8.8 pKi = 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10422787
644 8160 31 None -6 3 Rat 8.8 pKi = 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10422787
CHEMBL264100 8160 31 None -6 3 Rat 8.8 pKi = 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10422787
122227 8160 31 None -6 3 Mouse 8.8 pKi = 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8856107
3825 8160 31 None -6 3 Mouse 8.8 pKi = 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8856107
644 8160 31 None -6 3 Mouse 8.8 pKi = 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8856107
CHEMBL264100 8160 31 None -6 3 Mouse 8.8 pKi = 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8856107
662 10452 0 None - 1 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 756 14 2 8 6.3 COc1ccc2c(c1)ccc(c2)S(=O)(=O)N[C@@H](c1ccc2c(c1)OCO2)CC(=O)N[C@@H](C(=O)N(C(C)C)C)Cc1ccc(cc1)CN1[C@H](C)CCC[C@@H]1C 14747609
9853583 10452 0 None - 1 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 756 14 2 8 6.3 COc1ccc2c(c1)ccc(c2)S(=O)(=O)N[C@@H](c1ccc2c(c1)OCO2)CC(=O)N[C@@H](C(=O)N(C(C)C)C)Cc1ccc(cc1)CN1[C@H](C)CCC[C@@H]1C 14747609
CHEMBL2021721 10452 0 None - 1 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 756 14 2 8 6.3 COc1ccc2c(c1)ccc(c2)S(=O)(=O)N[C@@H](c1ccc2c(c1)OCO2)CC(=O)N[C@@H](C(=O)N(C(C)C)C)Cc1ccc(cc1)CN1[C@H](C)CCC[C@@H]1C 14747609
642 9088 19 None 12 2 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9111052
642 9088 19 None 12 2 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9313952
CHEMBL384721 9088 19 None 12 2 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9111052
CHEMBL384721 9088 19 None 12 2 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9313952
661 10052 0 None 63 2 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9276157
654 7354 0 None 10 3 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10422787
654 7354 0 None 10 3 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8995263
654 7354 0 None 10 3 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9276157
655 7355 0 None - 1 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 16368899
655 7355 0 None - 1 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9650825
122227 8160 31 None 6 3 Human 9.8 pKi = 9.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10422787
122227 8160 31 None 6 3 Human 9.8 pKi = 9.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8735629
122227 8160 31 None 6 3 Human 9.8 pKi = 9.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9111052
122227 8160 31 None 6 3 Human 9.8 pKi = 9.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9313952
3825 8160 31 None 6 3 Human 9.8 pKi = 9.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10422787
3825 8160 31 None 6 3 Human 9.8 pKi = 9.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8735629
3825 8160 31 None 6 3 Human 9.8 pKi = 9.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9111052
3825 8160 31 None 6 3 Human 9.8 pKi = 9.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9313952
644 8160 31 None 6 3 Human 9.8 pKi = 9.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10422787
644 8160 31 None 6 3 Human 9.8 pKi = 9.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8735629
644 8160 31 None 6 3 Human 9.8 pKi = 9.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9111052
644 8160 31 None 6 3 Human 9.8 pKi = 9.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9313952
CHEMBL264100 8160 31 None 6 3 Human 9.8 pKi = 9.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10422787
CHEMBL264100 8160 31 None 6 3 Human 9.8 pKi = 9.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8735629
CHEMBL264100 8160 31 None 6 3 Human 9.8 pKi = 9.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9111052
CHEMBL264100 8160 31 None 6 3 Human 9.8 pKi = 9.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9313952
658 9647 0 None 3981 2 Human 10.2 pKi None 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8995263
665 7760 3 None 1023 2 Human 10.5 pKi None 10.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 585 8 3 6 3.6 O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 12812482
9916412 7760 3 None 1023 2 Human 10.5 pKi None 10.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 585 8 3 6 3.6 O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 12812482
CHEMBL189123 7760 3 None 1023 2 Human 10.5 pKi None 10.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 585 8 3 6 3.6 O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 12812482
5128451 8162 0 None -2818 2 Human 5.8 pKi None 5.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10422787
5128451 8162 0 None -2818 2 Human 5.8 pKi None 5.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9313952
646 8162 0 None -2818 2 Human 5.8 pKi None 5.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10422787
646 8162 0 None -2818 2 Human 5.8 pKi None 5.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9313952
100978427 8161 0 None -35 2 Human 5.8 pKi None 5.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10422787
645 8161 0 None -35 2 Human 5.8 pKi None 5.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10422787
155817380 8175 0 None - 1 Human 5.9 pKi None 5.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9111052
648 8175 0 None - 1 Human 5.9 pKi None 5.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9111052
102061602 8174 0 None - 1 Human 6.2 pKi None 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9111052
647 8174 0 None - 1 Human 6.2 pKi None 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9111052
651 7050 0 None - 1 Human 6.2 pKi None 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9276157
667 8754 37 None -5128 6 Rat 6.3 pKi None 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10422787
71364 8754 37 None -5128 6 Rat 6.3 pKi None 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10422787
CHEMBL2028850 8754 37 None -5128 6 Rat 6.3 pKi None 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10422787
DB06196 8754 37 None -5128 6 Rat 6.3 pKi None 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10422787
123884 9086 14 None -87 3 Human 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10422787
123884 9086 14 None -87 3 Human 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8063797
123884 9086 14 None -87 3 Human 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9111052
123884 9086 14 None -87 3 Human 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9203620
123884 9086 14 None -87 3 Human 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9313952
641 9086 14 None -87 3 Human 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10422787
641 9086 14 None -87 3 Human 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8063797
641 9086 14 None -87 3 Human 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9111052
641 9086 14 None -87 3 Human 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9203620
641 9086 14 None -87 3 Human 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9313952
CHEMBL80472 9086 14 None -87 3 Human 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10422787
CHEMBL80472 9086 14 None -87 3 Human 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8063797
CHEMBL80472 9086 14 None -87 3 Human 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9111052
CHEMBL80472 9086 14 None -87 3 Human 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9203620
CHEMBL80472 9086 14 None -87 3 Human 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9313952
653 7353 0 None -316 4 Mouse 6.6 pKi None 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9276157
667 8754 37 None -1819 6 Human 6.7 pKi None 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10422787
667 8754 37 None -1819 6 Human 6.7 pKi None 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9313952
71364 8754 37 None -1819 6 Human 6.7 pKi None 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10422787
71364 8754 37 None -1819 6 Human 6.7 pKi None 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9313952
CHEMBL2028850 8754 37 None -1819 6 Human 6.7 pKi None 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10422787
CHEMBL2028850 8754 37 None -1819 6 Human 6.7 pKi None 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9313952
DB06196 8754 37 None -1819 6 Human 6.7 pKi None 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10422787
DB06196 8754 37 None -1819 6 Human 6.7 pKi None 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9313952
101607591 9210 0 None - 1 Human 6.8 pKi None 6.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9111052
637 9210 0 None - 1 Human 6.8 pKi None 6.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9111052
3081308 9646 0 None -15 2 Human 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8995263
657 9646 0 None -15 2 Human 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8995263
44316620 8902 0 None -19 2 Human 7.1 pKi None 7.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10882364
656 8902 0 None -19 2 Human 7.1 pKi None 7.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10882364
CHEMBL408846 8902 0 None -19 2 Human 7.1 pKi None 7.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10882364
665 7760 3 None -1023 2 Rat 7.2 pKi None 7.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 585 8 3 6 3.6 O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 12812482
9916412 7760 3 None -1023 2 Rat 7.2 pKi None 7.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 585 8 3 6 3.6 O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 12812482
CHEMBL189123 7760 3 None -1023 2 Rat 7.2 pKi None 7.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 585 8 3 6 3.6 O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 12812482
164234 10251 0 None 35 2 Rat 7.3 pKi None 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10422787
643 10251 0 None 35 2 Rat 7.3 pKi None 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10422787
100978427 8161 0 None 35 2 Rat 7.4 pKi None 7.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10422787
645 8161 0 None 35 2 Rat 7.4 pKi None 7.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10422787
661 10052 0 None -63 2 Mouse 7.4 pKi None 7.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9276157
663 8159 0 None -1 3 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10422787
663 8159 0 None -1 3 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9313952
663 8159 0 None -1 3 Rat 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10422787
640 10399 0 None - 1 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9111052
123884 9086 14 None -7 3 Rat 7.6 pKi None 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10422787
641 9086 14 None -7 3 Rat 7.6 pKi None 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10422787
CHEMBL80472 9086 14 None -7 3 Rat 7.6 pKi None 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10422787
663 8159 0 None 1 3 Mouse 7.6 pKi None 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8856107
653 7353 0 None -15 4 Human 7.9 pKi None 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8856115
653 7353 0 None -15 4 Human 7.9 pKi None 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9276157
5311111 8956 0 None 25 3 Human 8.0 pKi None 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10422787
5311111 8956 0 None 25 3 Human 8.0 pKi None 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9111052
5311111 8956 0 None 25 3 Human 8.0 pKi None 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9313952
650 8956 0 None 25 3 Human 8.0 pKi None 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10422787
650 8956 0 None 25 3 Human 8.0 pKi None 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9111052
650 8956 0 None 25 3 Human 8.0 pKi None 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9313952
659 9673 17 None -1 2 Human 8.0 pKi None 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 659 9 1 7 3.6 CN1CCN(CC1)C(=O)C1CCN(CC1)S(=O)(=O)c1ccc(c(c1)C(=O)N1CCOCC1)NCC(c1ccccc1)c1ccccc1 15341478
659 9673 17 None -1 2 Human 8.0 pKi None 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 659 9 1 7 3.6 CN1CCN(CC1)C(=O)C1CCN(CC1)S(=O)(=O)c1ccc(c(c1)C(=O)N1CCOCC1)NCC(c1ccccc1)c1ccccc1 15685199
9831083 9673 17 None -1 2 Human 8.0 pKi None 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 659 9 1 7 3.6 CN1CCN(CC1)C(=O)C1CCN(CC1)S(=O)(=O)c1ccc(c(c1)C(=O)N1CCOCC1)NCC(c1ccccc1)c1ccccc1 15341478
9831083 9673 17 None -1 2 Human 8.0 pKi None 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 659 9 1 7 3.6 CN1CCN(CC1)C(=O)C1CCN(CC1)S(=O)(=O)c1ccc(c(c1)C(=O)N1CCOCC1)NCC(c1ccccc1)c1ccccc1 15685199
CHEMBL273869 9673 17 None -1 2 Human 8.0 pKi None 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 659 9 1 7 3.6 CN1CCN(CC1)C(=O)C1CCN(CC1)S(=O)(=O)c1ccc(c(c1)C(=O)N1CCOCC1)NCC(c1ccccc1)c1ccccc1 15341478
CHEMBL273869 9673 17 None -1 2 Human 8.0 pKi None 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 659 9 1 7 3.6 CN1CCN(CC1)C(=O)C1CCN(CC1)S(=O)(=O)c1ccc(c(c1)C(=O)N1CCOCC1)NCC(c1ccccc1)c1ccccc1 15685199
642 9088 19 None -12 2 Mouse 8.1 pKi None 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8856107
CHEMBL384721 9088 19 None -12 2 Mouse 8.1 pKi None 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8856107
20814785 9977 0 None - 1 Human 8.2 pKi None 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 577 11 3 7 6.6 Clc1ccc(cc1)CNC(=O)C(Nc1nc(NCc2cccc(c2)Cl)nc(c1)n1ccnc1)CC1CCCCC1 10596850
660 9977 0 None - 1 Human 8.2 pKi None 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 577 11 3 7 6.6 Clc1ccc(cc1)CNC(=O)C(Nc1nc(NCc2cccc(c2)Cl)nc(c1)n1ccnc1)CC1CCCCC1 10596850
654 7354 0 None -17 3 Mouse 8.3 pKi None 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9276157
123884 9086 14 None 7 3 Mouse 8.4 pKi None 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8856107
641 9086 14 None 7 3 Mouse 8.4 pKi None 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8856107
CHEMBL80472 9086 14 None 7 3 Mouse 8.4 pKi None 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8856107
654 7354 0 None -10 3 Rat 8.6 pKi None 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10422787
10281725 7766 0 None 7 2 Rat 9.0 pKi None 9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 579 7 2 6 5.7 CCCN1C(=O)C(NC(=O)Nc2ccc(cc2)N2CCN(CC2)c2cccnc2)N=C(c2c1cccc2)C1CCCCC1 12723943
666 7766 0 None 7 2 Rat 9.0 pKi None 9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 579 7 2 6 5.7 CCCN1C(=O)C(NC(=O)Nc2ccc(cc2)N2CCN(CC2)c2cccnc2)N=C(c2c1cccc2)C1CCCCC1 12723943
CHEMBL299164 7766 0 None 7 2 Rat 9.0 pKi None 9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 579 7 2 6 5.7 CCCN1C(=O)C(NC(=O)Nc2ccc(cc2)N2CCN(CC2)c2cccnc2)N=C(c2c1cccc2)C1CCCCC1 12723943
10281725 7766 0 None -7 2 Human 9.2 pKi None 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 579 7 2 6 5.7 CCCN1C(=O)C(NC(=O)Nc2ccc(cc2)N2CCN(CC2)c2cccnc2)N=C(c2c1cccc2)C1CCCCC1 12723943
666 7766 0 None -7 2 Human 9.2 pKi None 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 579 7 2 6 5.7 CCCN1C(=O)C(NC(=O)Nc2ccc(cc2)N2CCN(CC2)c2cccnc2)N=C(c2c1cccc2)C1CCCCC1 12723943
CHEMBL299164 7766 0 None -7 2 Human 9.2 pKi None 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 579 7 2 6 5.7 CCCN1C(=O)C(NC(=O)Nc2ccc(cc2)N2CCN(CC2)c2cccnc2)N=C(c2c1cccc2)C1CCCCC1 12723943
5128451 8162 0 None 2818 2 Mouse 9.2 pKi None 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8856107
646 8162 0 None 2818 2 Mouse 9.2 pKi None 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8856107
652 7350 0 None - 1 Human 9.5 pKi None 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 16368899
636 10398 0 None - 1 Human 9.5 pKi None 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9111052