Ligand source activities (1 row/activity)
Ligands (move mouse cursor over ligand name to see structure) | Receptor | Assay information | Chemical information | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name |
GPCRdb ID |
#Vendors |
Reference ligand |
Fold selectivity |
# Tested GPCRs |
Species |
p-value (-log) |
Activity Type |
Activity Relation |
Activity Value |
AssayType |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
51353551 | 24906 | 16 | None | 1 | 3 | Human | 11.0 | pEC50 | = | 11 | Functional | ChEMBL | 605 | 8 | 3 | 5 | 5.0 | CC(C)N(C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(C(=O)O)c2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1016/j.bmcl.2015.03.051 | ||
CHEMBL1269257 | 24906 | 16 | None | 1 | 3 | Human | 11.0 | pEC50 | = | 11 | Functional | ChEMBL | 605 | 8 | 3 | 5 | 5.0 | CC(C)N(C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(C(=O)O)c2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1016/j.bmcl.2015.03.051 | ||
51353551 | 24906 | 16 | None | 1 | 3 | Human | 10.9 | pEC50 | = | 10.9 | Functional | ChEMBL | 605 | 8 | 3 | 5 | 5.0 | CC(C)N(C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(C(=O)O)c2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1016/j.bmcl.2015.03.051 | ||
CHEMBL1269257 | 24906 | 16 | None | 1 | 3 | Human | 10.9 | pEC50 | = | 10.9 | Functional | ChEMBL | 605 | 8 | 3 | 5 | 5.0 | CC(C)N(C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(C(=O)O)c2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1016/j.bmcl.2015.03.051 | ||
10649606 | 56390 | 0 | None | 4 | 2 | Human | 10.9 | pEC50 | = | 10.9 | Functional | ChEMBL | 519 | 6 | 3 | 4 | 4.5 | O=C(CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)Nc1ccccc1 | 10.1016/j.bmcl.2015.03.051 | ||
CHEMBL156605 | 56390 | 0 | None | 4 | 2 | Human | 10.9 | pEC50 | = | 10.9 | Functional | ChEMBL | 519 | 6 | 3 | 4 | 4.5 | O=C(CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)Nc1ccccc1 | 10.1016/j.bmcl.2015.03.051 | ||
10649606 | 56390 | 0 | None | 4 | 2 | Human | 10.7 | pEC50 | = | 10.7 | Functional | ChEMBL | 519 | 6 | 3 | 4 | 4.5 | O=C(CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)Nc1ccccc1 | 10.1016/j.bmcl.2015.03.051 | ||
CHEMBL156605 | 56390 | 0 | None | 4 | 2 | Human | 10.7 | pEC50 | = | 10.7 | Functional | ChEMBL | 519 | 6 | 3 | 4 | 4.5 | O=C(CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)Nc1ccccc1 | 10.1016/j.bmcl.2015.03.051 | ||
44336539 | 11916 | 0 | None | 1 | 3 | Human | 10.7 | pEC50 | = | 10.7 | Functional | ChEMBL | 563 | 7 | 2 | 5 | 4.6 | COc1ccc(N(C)C(=O)CN2C(=O)C(NC(=O)Nc3ccccc3)C(=O)N(c3ccccc3)c3ccccc32)cc1 | 10.1016/j.bmcl.2015.03.051 | ||
CHEMBL105775 | 11916 | 0 | None | 1 | 3 | Human | 10.7 | pEC50 | = | 10.7 | Functional | ChEMBL | 563 | 7 | 2 | 5 | 4.6 | COc1ccc(N(C)C(=O)CN2C(=O)C(NC(=O)Nc3ccccc3)C(=O)N(c3ccccc3)c3ccccc32)cc1 | 10.1016/j.bmcl.2015.03.051 | ||
10819755 | 172221 | 0 | None | 218776 | 2 | Human | 10.6 | pEC50 | = | 10.6 | Functional | ChEMBL | 976 | 28 | 9 | 11 | 1.6 | CCCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
CHEMBL423907 | 172221 | 0 | None | 218776 | 2 | Human | 10.6 | pEC50 | = | 10.6 | Functional | ChEMBL | 976 | 28 | 9 | 11 | 1.6 | CCCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
24769543 | 195483 | 0 | None | 2 | 2 | Human | 10.5 | pEC50 | = | 10.5 | Functional | ChEMBL | 649 | 9 | 2 | 7 | 5.7 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)C[C@H]3CNC(C)=O)nc2-c2ccc(C)cc2F)c1 | 10.1016/j.bmcl.2008.07.083 | ||
CHEMBL504406 | 195483 | 0 | None | 2 | 2 | Human | 10.5 | pEC50 | = | 10.5 | Functional | ChEMBL | 649 | 9 | 2 | 7 | 5.7 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)C[C@H]3CNC(C)=O)nc2-c2ccc(C)cc2F)c1 | 10.1016/j.bmcl.2008.07.083 | ||
44562302 | 194970 | 0 | None | - | 1 | Human | 10.5 | pEC50 | = | 10.5 | Functional | ChEMBL | 666 | 11 | 2 | 8 | 5.7 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)C[C@H]3COCC(=O)O)nc2-c2ccc(C)cc2F)c1 | 10.1016/j.bmcl.2008.07.083 | ||
CHEMBL498958 | 194970 | 0 | None | - | 1 | Human | 10.5 | pEC50 | = | 10.5 | Functional | ChEMBL | 666 | 11 | 2 | 8 | 5.7 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)C[C@H]3COCC(=O)O)nc2-c2ccc(C)cc2F)c1 | 10.1016/j.bmcl.2008.07.083 | ||
24769604 | 195468 | 0 | None | -1 | 2 | Mouse | 10.5 | pEC50 | = | 10.5 | Functional | ChEMBL | 663 | 9 | 2 | 7 | 6.1 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)C[C@H]3C(=O)NC(C)C)nc2-c2ccc(C)cc2F)c1 | 10.1016/j.bmcl.2008.07.083 | ||
CHEMBL504114 | 195468 | 0 | None | -1 | 2 | Mouse | 10.5 | pEC50 | = | 10.5 | Functional | ChEMBL | 663 | 9 | 2 | 7 | 6.1 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)C[C@H]3C(=O)NC(C)C)nc2-c2ccc(C)cc2F)c1 | 10.1016/j.bmcl.2008.07.083 | ||
10649606 | 56390 | 0 | None | 4 | 2 | Human | 10.4 | pEC50 | = | 10.4 | Functional | ChEMBL | 519 | 6 | 3 | 4 | 4.5 | O=C(CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)Nc1ccccc1 | 10.1016/j.bmcl.2015.03.051 | ||
CHEMBL156605 | 56390 | 0 | None | 4 | 2 | Human | 10.4 | pEC50 | = | 10.4 | Functional | ChEMBL | 519 | 6 | 3 | 4 | 4.5 | O=C(CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)Nc1ccccc1 | 10.1016/j.bmcl.2015.03.051 | ||
44562297 | 195402 | 0 | None | - | 1 | Human | 10.4 | pEC50 | = | 10.4 | Functional | ChEMBL | 631 | 9 | 2 | 7 | 5.6 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)C[C@@H]3CNC(C)=O)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | ||
CHEMBL502974 | 195402 | 0 | None | - | 1 | Human | 10.4 | pEC50 | = | 10.4 | Functional | ChEMBL | 631 | 9 | 2 | 7 | 5.6 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)C[C@@H]3CNC(C)=O)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | ||
4627 | 7609 | 50 | None | -1 | 6 | Human | 10.4 | pEC50 | = | 10.4 | Functional | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b01558 | ||||
864 | 7609 | 50 | None | -1 | 6 | Human | 10.4 | pEC50 | = | 10.4 | Functional | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b01558 | ||||
9833444 | 7609 | 50 | None | -1 | 6 | Human | 10.4 | pEC50 | = | 10.4 | Functional | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b01558 | ||||
CHEMBL1121 | 7609 | 50 | None | -1 | 6 | Human | 10.4 | pEC50 | = | 10.4 | Functional | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b01558 | ||||
DB09142 | 7609 | 50 | None | -1 | 6 | Human | 10.4 | pEC50 | = | 10.4 | Functional | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b01558 | ||||
24861113 | 194969 | 0 | None | 24 | 2 | Human | 10.3 | pEC50 | = | 10.3 | Functional | ChEMBL | 564 | 7 | 1 | 6 | 5.9 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(F)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | ||
CHEMBL498942 | 194969 | 0 | None | 24 | 2 | Human | 10.3 | pEC50 | = | 10.3 | Functional | ChEMBL | 564 | 7 | 1 | 6 | 5.9 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(F)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | ||
CHEMBL506201 | 194969 | 0 | None | 24 | 2 | Human | 10.3 | pEC50 | = | 10.3 | Functional | ChEMBL | 564 | 7 | 1 | 6 | 5.9 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(F)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | ||
44336539 | 11916 | 0 | None | 1 | 3 | Human | 10.3 | pEC50 | = | 10.3 | Functional | ChEMBL | 563 | 7 | 2 | 5 | 4.6 | COc1ccc(N(C)C(=O)CN2C(=O)C(NC(=O)Nc3ccccc3)C(=O)N(c3ccccc3)c3ccccc32)cc1 | 10.1016/j.bmcl.2015.03.051 | ||
CHEMBL105775 | 11916 | 0 | None | 1 | 3 | Human | 10.3 | pEC50 | = | 10.3 | Functional | ChEMBL | 563 | 7 | 2 | 5 | 4.6 | COc1ccc(N(C)C(=O)CN2C(=O)C(NC(=O)Nc3ccccc3)C(=O)N(c3ccccc3)c3ccccc32)cc1 | 10.1016/j.bmcl.2015.03.051 | ||
24861114 | 195918 | 5 | None | - | 1 | Human | 10.3 | pEC50 | = | 10.3 | Functional | ChEMBL | 582 | 7 | 1 | 6 | 6.0 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(F)cc2F)c1 | 10.1016/j.bmcl.2008.06.057 | ||
CHEMBL510690 | 195918 | 5 | None | - | 1 | Human | 10.3 | pEC50 | = | 10.3 | Functional | ChEMBL | 582 | 7 | 1 | 6 | 6.0 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(F)cc2F)c1 | 10.1016/j.bmcl.2008.06.057 | ||
44562301 | 195830 | 0 | None | 3 | 2 | Human | 10.3 | pEC50 | = | 10.3 | Functional | ChEMBL | 645 | 9 | 2 | 7 | 6.0 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)C[C@H]3C(=O)NC(C)C)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | ||
CHEMBL509464 | 195830 | 0 | None | 3 | 2 | Human | 10.3 | pEC50 | = | 10.3 | Functional | ChEMBL | 645 | 9 | 2 | 7 | 6.0 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)C[C@H]3C(=O)NC(C)C)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | ||
24861060 | 195506 | 0 | None | 5 | 3 | Human | 10.3 | pEC50 | = | 10.3 | Functional | ChEMBL | 578 | 7 | 1 | 6 | 6.2 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2F)c1 | 10.1016/j.bmcl.2008.07.083 | ||
CHEMBL446789 | 195506 | 0 | None | 5 | 3 | Human | 10.3 | pEC50 | = | 10.3 | Functional | ChEMBL | 578 | 7 | 1 | 6 | 6.2 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2F)c1 | 10.1016/j.bmcl.2008.07.083 | ||
CHEMBL504861 | 195506 | 0 | None | 5 | 3 | Human | 10.3 | pEC50 | = | 10.3 | Functional | ChEMBL | 578 | 7 | 1 | 6 | 6.2 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2F)c1 | 10.1016/j.bmcl.2008.07.083 | ||
24861060 | 195506 | 0 | None | 5 | 3 | Human | 10.3 | pEC50 | = | 10.3 | Functional | ChEMBL | 578 | 7 | 1 | 6 | 6.2 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2F)c1 | 10.1016/j.bmcl.2008.06.057 | ||
CHEMBL446789 | 195506 | 0 | None | 5 | 3 | Human | 10.3 | pEC50 | = | 10.3 | Functional | ChEMBL | 578 | 7 | 1 | 6 | 6.2 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2F)c1 | 10.1016/j.bmcl.2008.06.057 | ||
CHEMBL504861 | 195506 | 0 | None | 5 | 3 | Human | 10.3 | pEC50 | = | 10.3 | Functional | ChEMBL | 578 | 7 | 1 | 6 | 6.2 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2F)c1 | 10.1016/j.bmcl.2008.06.057 | ||
155530671 | 178341 | 0 | None | 47863 | 2 | Human | 10.2 | pEC50 | = | 10.2 | Functional | ChEMBL | 1627 | 65 | 14 | 19 | 4.1 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](CCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)NC(=O)Cc1ccc(O)cc1)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
CHEMBL4464703 | 178341 | 0 | None | 47863 | 2 | Human | 10.2 | pEC50 | = | 10.2 | Functional | ChEMBL | 1627 | 65 | 14 | 19 | 4.1 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](CCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)NC(=O)Cc1ccc(O)cc1)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
46869398 | 68698 | 0 | None | 5 | 3 | Human | 10.2 | pEC50 | = | 10.2 | Functional | ChEMBL | 576 | 6 | 1 | 6 | 6.1 | COc1ccc(-c2cnc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2F)cc1 | 10.1016/j.bmcl.2011.03.069 | ||
CHEMBL1774043 | 68698 | 0 | None | 5 | 3 | Human | 10.2 | pEC50 | = | 10.2 | Functional | ChEMBL | 576 | 6 | 1 | 6 | 6.1 | COc1ccc(-c2cnc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2F)cc1 | 10.1016/j.bmcl.2011.03.069 | ||
24769605 | 185498 | 0 | None | - | 1 | Human | 10.2 | pEC50 | = | 10.2 | Functional | ChEMBL | 605 | 10 | 1 | 8 | 5.2 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)C[C@H]3COCC(=O)O)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | ||
CHEMBL468372 | 185498 | 0 | None | - | 1 | Human | 10.2 | pEC50 | = | 10.2 | Functional | ChEMBL | 605 | 10 | 1 | 8 | 5.2 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)C[C@H]3COCC(=O)O)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | ||
53233689 | 68630 | 0 | None | 2 | 3 | Human | 10.2 | pEC50 | = | 10.2 | Functional | ChEMBL | 604 | 5 | 1 | 7 | 5.8 | Cc1ccc(-c2nc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)ncc2-c2ccc3c(c2)OCCO3)c(F)c1 | 10.1016/j.bmcl.2011.03.069 | ||
CHEMBL1773877 | 68630 | 0 | None | 2 | 3 | Human | 10.2 | pEC50 | = | 10.2 | Functional | ChEMBL | 604 | 5 | 1 | 7 | 5.8 | Cc1ccc(-c2nc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)ncc2-c2ccc3c(c2)OCCO3)c(F)c1 | 10.1016/j.bmcl.2011.03.069 | ||
155524181 | 177632 | 0 | None | 4 | 2 | Human | 10.2 | pEC50 | = | 10.2 | Functional | ChEMBL | 1820 | 71 | 18 | 22 | 2.7 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
CHEMBL4453982 | 177632 | 0 | None | 4 | 2 | Human | 10.2 | pEC50 | = | 10.2 | Functional | ChEMBL | 1820 | 71 | 18 | 22 | 2.7 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
24769604 | 195468 | 0 | None | 1 | 2 | Human | 10.2 | pEC50 | = | 10.2 | Functional | ChEMBL | 663 | 9 | 2 | 7 | 6.1 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)C[C@H]3C(=O)NC(C)C)nc2-c2ccc(C)cc2F)c1 | 10.1016/j.bmcl.2008.07.083 | ||
CHEMBL504114 | 195468 | 0 | None | 1 | 2 | Human | 10.2 | pEC50 | = | 10.2 | Functional | ChEMBL | 663 | 9 | 2 | 7 | 6.1 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)C[C@H]3C(=O)NC(C)C)nc2-c2ccc(C)cc2F)c1 | 10.1016/j.bmcl.2008.07.083 | ||
44562304 | 195654 | 0 | None | - | 1 | Human | 10.1 | pEC50 | = | 10.1 | Functional | ChEMBL | 664 | 9 | 3 | 7 | 5.5 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)C[C@H]3CNC(=O)NC)nc2-c2ccc(C)cc2F)c1 | 10.1016/j.bmcl.2008.07.083 | ||
CHEMBL507094 | 195654 | 0 | None | - | 1 | Human | 10.1 | pEC50 | = | 10.1 | Functional | ChEMBL | 664 | 9 | 3 | 7 | 5.5 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)C[C@H]3CNC(=O)NC)nc2-c2ccc(C)cc2F)c1 | 10.1016/j.bmcl.2008.07.083 | ||
24861394 | 195834 | 0 | None | - | 1 | Human | 10.1 | pEC50 | = | 10.1 | Functional | ChEMBL | 592 | 5 | 1 | 7 | 5.6 | Cc1ccc(-c2nc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)cn2-c2ccc3c(c2)OCCO3)c(F)c1 | 10.1016/j.bmcl.2008.06.057 | ||
CHEMBL509519 | 195834 | 0 | None | - | 1 | Human | 10.1 | pEC50 | = | 10.1 | Functional | ChEMBL | 592 | 5 | 1 | 7 | 5.6 | Cc1ccc(-c2nc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)cn2-c2ccc3c(c2)OCCO3)c(F)c1 | 10.1016/j.bmcl.2008.06.057 | ||
44578457 | 179250 | 0 | None | - | 1 | Human | 10.1 | pEC50 | = | 10.1 | Functional | ChEMBL | 546 | 6 | 1 | 6 | 5.7 | COc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | ||
CHEMBL448221 | 179250 | 0 | None | - | 1 | Human | 10.1 | pEC50 | = | 10.1 | Functional | ChEMBL | 546 | 6 | 1 | 6 | 5.7 | COc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | ||
44562300 | 195416 | 0 | None | - | 1 | Human | 10.1 | pEC50 | = | 10.1 | Functional | ChEMBL | 645 | 9 | 2 | 7 | 6.0 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)C[C@@H]3C(=O)NC(C)C)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | ||
CHEMBL503107 | 195416 | 0 | None | - | 1 | Human | 10.1 | pEC50 | = | 10.1 | Functional | ChEMBL | 645 | 9 | 2 | 7 | 6.0 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)C[C@@H]3C(=O)NC(C)C)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | ||
24769546 | 179468 | 0 | None | 2 | 2 | Human | 10.1 | pEC50 | = | 10.1 | Functional | ChEMBL | 618 | 9 | 2 | 8 | 4.3 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)C[C@H]3C(=O)NCC(=O)O)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | ||
CHEMBL450105 | 179468 | 0 | None | 2 | 2 | Human | 10.1 | pEC50 | = | 10.1 | Functional | ChEMBL | 618 | 9 | 2 | 8 | 4.3 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)C[C@H]3C(=O)NCC(=O)O)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | ||
24861391 | 195530 | 0 | None | 2 | 2 | Human | 10.0 | pEC50 | = | 10.0 | Functional | ChEMBL | 578 | 5 | 1 | 7 | 5.3 | O=C(O)c1cc(N2CCN(C(=O)c3cn(-c4ccc5c(c4)OCCO5)c(-c4ccc(F)cc4)n3)CC2)cc2ccccc12 | 10.1016/j.bmcl.2008.06.057 | ||
CHEMBL505225 | 195530 | 0 | None | 2 | 2 | Human | 10.0 | pEC50 | = | 10.0 | Functional | ChEMBL | 578 | 5 | 1 | 7 | 5.3 | O=C(O)c1cc(N2CCN(C(=O)c3cn(-c4ccc5c(c4)OCCO5)c(-c4ccc(F)cc4)n3)CC2)cc2ccccc12 | 10.1016/j.bmcl.2008.06.057 | ||
CHEMBL505969 | 195530 | 0 | None | 2 | 2 | Human | 10.0 | pEC50 | = | 10.0 | Functional | ChEMBL | 578 | 5 | 1 | 7 | 5.3 | O=C(O)c1cc(N2CCN(C(=O)c3cn(-c4ccc5c(c4)OCCO5)c(-c4ccc(F)cc4)n3)CC2)cc2ccccc12 | 10.1016/j.bmcl.2008.06.057 | ||
16755781 | 195564 | 12 | None | 9 | 3 | Human | 10.0 | pEC50 | = | 10.0 | Functional | ChEMBL | 560 | 7 | 1 | 6 | 6.1 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | ||
CHEMBL443189 | 195564 | 12 | None | 9 | 3 | Human | 10.0 | pEC50 | = | 10.0 | Functional | ChEMBL | 560 | 7 | 1 | 6 | 6.1 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | ||
CHEMBL505409 | 195564 | 12 | None | 9 | 3 | Human | 10.0 | pEC50 | = | 10.0 | Functional | ChEMBL | 560 | 7 | 1 | 6 | 6.1 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | ||
CHEMBL505727 | 195564 | 12 | None | 9 | 3 | Human | 10.0 | pEC50 | = | 10.0 | Functional | ChEMBL | 560 | 7 | 1 | 6 | 6.1 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | ||
16755781 | 195564 | 12 | None | 9 | 3 | Human | 10.0 | pEC50 | = | 10.0 | Functional | ChEMBL | 560 | 7 | 1 | 6 | 6.1 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | ||
CHEMBL443189 | 195564 | 12 | None | 9 | 3 | Human | 10.0 | pEC50 | = | 10.0 | Functional | ChEMBL | 560 | 7 | 1 | 6 | 6.1 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | ||
CHEMBL505409 | 195564 | 12 | None | 9 | 3 | Human | 10.0 | pEC50 | = | 10.0 | Functional | ChEMBL | 560 | 7 | 1 | 6 | 6.1 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | ||
CHEMBL505727 | 195564 | 12 | None | 9 | 3 | Human | 10.0 | pEC50 | = | 10.0 | Functional | ChEMBL | 560 | 7 | 1 | 6 | 6.1 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | ||
44562298 | 178230 | 0 | None | - | 1 | Human | 10.0 | pEC50 | = | 10.0 | Functional | ChEMBL | 667 | 10 | 2 | 8 | 5.0 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)C[C@@H]3CNS(C)(=O)=O)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | ||
CHEMBL446324 | 178230 | 0 | None | - | 1 | Human | 10.0 | pEC50 | = | 10.0 | Functional | ChEMBL | 667 | 10 | 2 | 8 | 5.0 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)C[C@@H]3CNS(C)(=O)=O)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | ||
44562312 | 195424 | 0 | None | - | 1 | Human | 10.0 | pEC50 | = | 10.0 | Functional | ChEMBL | 588 | 8 | 1 | 7 | 5.3 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)C[C@H]3CNC(C)=O)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | ||
CHEMBL503331 | 195424 | 0 | None | - | 1 | Human | 10.0 | pEC50 | = | 10.0 | Functional | ChEMBL | 588 | 8 | 1 | 7 | 5.3 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)C[C@H]3CNC(C)=O)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | ||
44562306 | 195708 | 0 | None | 8 | 2 | Human | 10.0 | pEC50 | = | 10.0 | Functional | ChEMBL | 605 | 10 | 1 | 8 | 5.2 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)C[C@@H]3COCC(=O)O)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | ||
CHEMBL508004 | 195708 | 0 | None | 8 | 2 | Human | 10.0 | pEC50 | = | 10.0 | Functional | ChEMBL | 605 | 10 | 1 | 8 | 5.2 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)C[C@@H]3COCC(=O)O)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | ||
44562296 | 195782 | 0 | None | - | 1 | Human | 10.0 | pEC50 | = | 10.0 | Functional | ChEMBL | 648 | 11 | 2 | 8 | 5.5 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)C[C@@H]3COCC(=O)O)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | ||
CHEMBL508772 | 195782 | 0 | None | - | 1 | Human | 10.0 | pEC50 | = | 10.0 | Functional | ChEMBL | 648 | 11 | 2 | 8 | 5.5 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)C[C@@H]3COCC(=O)O)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | ||
44562307 | 179485 | 0 | None | - | 1 | Human | 10.0 | pEC50 | = | 10 | Functional | ChEMBL | 588 | 8 | 1 | 7 | 5.3 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)C[C@@H]3CNC(C)=O)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | ||
CHEMBL450443 | 179485 | 0 | None | - | 1 | Human | 10.0 | pEC50 | = | 10 | Functional | ChEMBL | 588 | 8 | 1 | 7 | 5.3 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)C[C@@H]3CNC(C)=O)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | ||
44562303 | 179567 | 0 | None | - | 1 | Human | 10.0 | pEC50 | = | 10 | Functional | ChEMBL | 685 | 10 | 2 | 8 | 5.1 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)C[C@H]3CNS(C)(=O)=O)nc2-c2ccc(C)cc2F)c1 | 10.1016/j.bmcl.2008.07.083 | ||
CHEMBL451342 | 179567 | 0 | None | - | 1 | Human | 10.0 | pEC50 | = | 10 | Functional | ChEMBL | 685 | 10 | 2 | 8 | 5.1 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)C[C@H]3CNS(C)(=O)=O)nc2-c2ccc(C)cc2F)c1 | 10.1016/j.bmcl.2008.07.083 | ||
CHEMBL386682 | 219166 | 0 | None | 60 | 2 | Guinea pig | 10.0 | pEC50 | = | 10 | Functional | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN(C)C(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00093a013 | ||||
155535107 | 178793 | 0 | None | 323 | 2 | Human | 10.0 | pEC50 | = | 10.0 | Functional | ChEMBL | 1904 | 73 | 19 | 22 | 4.7 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
CHEMBL4471525 | 178793 | 0 | None | 323 | 2 | Human | 10.0 | pEC50 | = | 10.0 | Functional | ChEMBL | 1904 | 73 | 19 | 22 | 4.7 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
155537344 | 179097 | 0 | None | 46773 | 2 | Human | 10.0 | pEC50 | = | 10.0 | Functional | ChEMBL | 1848 | 72 | 16 | 22 | 3.6 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
CHEMBL4475304 | 179097 | 0 | None | 46773 | 2 | Human | 10.0 | pEC50 | = | 10.0 | Functional | ChEMBL | 1848 | 72 | 16 | 22 | 3.6 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
155532425 | 178527 | 0 | None | 3 | 2 | Human | 10.0 | pEC50 | = | 10.0 | Functional | ChEMBL | 1822 | 71 | 18 | 23 | 2.5 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)[C@@H](C)CC | 10.1021/acs.jmedchem.8b01558 | ||
CHEMBL4467338 | 178527 | 0 | None | 3 | 2 | Human | 10.0 | pEC50 | = | 10.0 | Functional | ChEMBL | 1822 | 71 | 18 | 23 | 2.5 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)[C@@H](C)CC | 10.1021/acs.jmedchem.8b01558 | ||
24769546 | 179468 | 0 | None | -2 | 2 | Mouse | 10.0 | pEC50 | = | 10.0 | Functional | ChEMBL | 618 | 9 | 2 | 8 | 4.3 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)C[C@H]3C(=O)NCC(=O)O)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | ||
CHEMBL450105 | 179468 | 0 | None | -2 | 2 | Mouse | 10.0 | pEC50 | = | 10.0 | Functional | ChEMBL | 618 | 9 | 2 | 8 | 4.3 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)C[C@H]3C(=O)NCC(=O)O)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | ||
44562301 | 195830 | 0 | None | -3 | 2 | Mouse | 10.0 | pEC50 | = | 10.0 | Functional | ChEMBL | 645 | 9 | 2 | 7 | 6.0 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)C[C@H]3C(=O)NC(C)C)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | ||
CHEMBL509464 | 195830 | 0 | None | -3 | 2 | Mouse | 10.0 | pEC50 | = | 10.0 | Functional | ChEMBL | 645 | 9 | 2 | 7 | 6.0 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)C[C@H]3C(=O)NC(C)C)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | ||
155555346 | 181151 | 0 | None | 3 | 2 | Human | 9.9 | pEC50 | = | 9.9 | Functional | ChEMBL | 1836 | 71 | 17 | 23 | 2.9 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
CHEMBL4551834 | 181151 | 0 | None | 3 | 2 | Human | 9.9 | pEC50 | = | 9.9 | Functional | ChEMBL | 1836 | 71 | 17 | 23 | 2.9 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
155557064 | 181371 | 0 | None | - | 1 | Human | 9.9 | pEC50 | = | 9.9 | Functional | ChEMBL | 1998 | 75 | 18 | 24 | 4.5 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1C)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
CHEMBL4557012 | 181371 | 0 | None | - | 1 | Human | 9.9 | pEC50 | = | 9.9 | Functional | ChEMBL | 1998 | 75 | 18 | 24 | 4.5 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1C)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
44336539 | 11916 | 0 | None | 1 | 3 | Human | 9.9 | pEC50 | = | 9.9 | Functional | ChEMBL | 563 | 7 | 2 | 5 | 4.6 | COc1ccc(N(C)C(=O)CN2C(=O)C(NC(=O)Nc3ccccc3)C(=O)N(c3ccccc3)c3ccccc32)cc1 | 10.1016/j.bmcl.2015.03.051 | ||
CHEMBL105775 | 11916 | 0 | None | 1 | 3 | Human | 9.9 | pEC50 | = | 9.9 | Functional | ChEMBL | 563 | 7 | 2 | 5 | 4.6 | COc1ccc(N(C)C(=O)CN2C(=O)C(NC(=O)Nc3ccccc3)C(=O)N(c3ccccc3)c3ccccc32)cc1 | 10.1016/j.bmcl.2015.03.051 | ||
44578729 | 196410 | 0 | None | - | 1 | Human | 9.9 | pEC50 | = | 9.9 | Functional | ChEMBL | 531 | 4 | 0 | 7 | 5.1 | Cc1ccc(-c2nc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)cn2-c2ccc3c(c2)OCCO3)cc1 | 10.1016/j.bmcl.2008.06.057 | ||
CHEMBL514953 | 196410 | 0 | None | - | 1 | Human | 9.9 | pEC50 | = | 9.9 | Functional | ChEMBL | 531 | 4 | 0 | 7 | 5.1 | Cc1ccc(-c2nc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)cn2-c2ccc3c(c2)OCCO3)cc1 | 10.1016/j.bmcl.2008.06.057 | ||
53233689 | 68630 | 0 | None | -2 | 3 | Mouse | 9.9 | pEC50 | = | 9.9 | Functional | ChEMBL | 604 | 5 | 1 | 7 | 5.8 | Cc1ccc(-c2nc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)ncc2-c2ccc3c(c2)OCCO3)c(F)c1 | 10.1016/j.bmcl.2011.03.069 | ||
CHEMBL1773877 | 68630 | 0 | None | -2 | 3 | Mouse | 9.9 | pEC50 | = | 9.9 | Functional | ChEMBL | 604 | 5 | 1 | 7 | 5.8 | Cc1ccc(-c2nc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)ncc2-c2ccc3c(c2)OCCO3)c(F)c1 | 10.1016/j.bmcl.2011.03.069 | ||
46235271 | 80423 | 2 | None | 3 | 3 | Human | 9.9 | pEC50 | = | 9.9 | Functional | ChEMBL | 649 | 7 | 1 | 6 | 6.7 | Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1021/acs.jmedchem.5b01110 | ||
CHEMBL2017835 | 80423 | 2 | None | 3 | 3 | Human | 9.9 | pEC50 | = | 9.9 | Functional | ChEMBL | 649 | 7 | 1 | 6 | 6.7 | Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1021/acs.jmedchem.5b01110 | ||
155516677 | 176868 | 0 | None | 1 | 2 | Human | 9.9 | pEC50 | = | 9.9 | Functional | ChEMBL | 1822 | 72 | 18 | 23 | 2.7 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
CHEMBL4443415 | 176868 | 0 | None | 1 | 2 | Human | 9.9 | pEC50 | = | 9.9 | Functional | ChEMBL | 1822 | 72 | 18 | 23 | 2.7 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
155544674 | 181715 | 0 | None | 1 | 2 | Human | 9.9 | pEC50 | = | 9.9 | Functional | ChEMBL | 1822 | 71 | 18 | 23 | 2.5 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
CHEMBL4565336 | 181715 | 0 | None | 1 | 2 | Human | 9.9 | pEC50 | = | 9.9 | Functional | ChEMBL | 1822 | 71 | 18 | 23 | 2.5 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
44578728 | 186237 | 0 | None | - | 1 | Human | 9.9 | pEC50 | = | 9.9 | Functional | ChEMBL | 535 | 6 | 0 | 6 | 5.9 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(C)cc2F)c1 | 10.1016/j.bmcl.2008.06.057 | ||
CHEMBL474067 | 186237 | 0 | None | - | 1 | Human | 9.9 | pEC50 | = | 9.9 | Functional | ChEMBL | 535 | 6 | 0 | 6 | 5.9 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(C)cc2F)c1 | 10.1016/j.bmcl.2008.06.057 | ||
44562299 | 195648 | 0 | None | - | 1 | Human | 9.9 | pEC50 | = | 9.9 | Functional | ChEMBL | 646 | 9 | 3 | 7 | 5.4 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)C[C@@H]3CNC(=O)NC)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | ||
CHEMBL507051 | 195648 | 0 | None | - | 1 | Human | 9.9 | pEC50 | = | 9.9 | Functional | ChEMBL | 646 | 9 | 3 | 7 | 5.4 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)C[C@@H]3CNC(=O)NC)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | ||
24769543 | 195483 | 0 | None | -2 | 2 | Mouse | 9.9 | pEC50 | = | 9.9 | Functional | ChEMBL | 649 | 9 | 2 | 7 | 5.7 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)C[C@H]3CNC(C)=O)nc2-c2ccc(C)cc2F)c1 | 10.1016/j.bmcl.2008.07.083 | ||
CHEMBL504406 | 195483 | 0 | None | -2 | 2 | Mouse | 9.9 | pEC50 | = | 9.9 | Functional | ChEMBL | 649 | 9 | 2 | 7 | 5.7 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)C[C@H]3CNC(C)=O)nc2-c2ccc(C)cc2F)c1 | 10.1016/j.bmcl.2008.07.083 | ||
155536333 | 178951 | 0 | None | - | 1 | Human | 9.9 | pEC50 | = | 9.9 | Functional | ChEMBL | 1865 | 71 | 17 | 24 | 1.3 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(N)=O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
CHEMBL4473468 | 178951 | 0 | None | - | 1 | Human | 9.9 | pEC50 | = | 9.9 | Functional | ChEMBL | 1865 | 71 | 17 | 24 | 1.3 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(N)=O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
24861392 | 179697 | 0 | None | - | 1 | Human | 9.9 | pEC50 | = | 9.9 | Functional | ChEMBL | 574 | 5 | 1 | 7 | 5.4 | Cc1ccc(-c2nc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)cn2-c2ccc3c(c2)OCCO3)cc1 | 10.1016/j.bmcl.2008.06.057 | ||
CHEMBL451644 | 179697 | 0 | None | - | 1 | Human | 9.9 | pEC50 | = | 9.9 | Functional | ChEMBL | 574 | 5 | 1 | 7 | 5.4 | Cc1ccc(-c2nc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)cn2-c2ccc3c(c2)OCCO3)cc1 | 10.1016/j.bmcl.2008.06.057 | ||
44562314 | 195541 | 0 | None | - | 1 | Human | 9.9 | pEC50 | = | 9.9 | Functional | ChEMBL | 602 | 8 | 1 | 7 | 5.7 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)C[C@H]3C(=O)NC(C)C)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | ||
CHEMBL505432 | 195541 | 0 | None | - | 1 | Human | 9.9 | pEC50 | = | 9.9 | Functional | ChEMBL | 602 | 8 | 1 | 7 | 5.7 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)C[C@H]3C(=O)NC(C)C)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | ||
155564421 | 182047 | 0 | None | 12302 | 2 | Human | 9.8 | pEC50 | = | 9.8 | Functional | ChEMBL | 1770 | 69 | 16 | 21 | 3.7 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
CHEMBL4572516 | 182047 | 0 | None | 12302 | 2 | Human | 9.8 | pEC50 | = | 9.8 | Functional | ChEMBL | 1770 | 69 | 16 | 21 | 3.7 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
155524770 | 177717 | 0 | None | 12882 | 2 | Human | 9.8 | pEC50 | = | 9.8 | Functional | ChEMBL | 1641 | 66 | 14 | 19 | 4.5 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)NC(=O)Cc1ccc(O)cc1)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
CHEMBL4455361 | 177717 | 0 | None | 12882 | 2 | Human | 9.8 | pEC50 | = | 9.8 | Functional | ChEMBL | 1641 | 66 | 14 | 19 | 4.5 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)NC(=O)Cc1ccc(O)cc1)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
44562309 | 178361 | 0 | None | - | 1 | Human | 9.8 | pEC50 | = | 9.8 | Functional | ChEMBL | 603 | 8 | 2 | 7 | 5.1 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)C[C@@H]3CNC(=O)NC)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | ||
CHEMBL446502 | 178361 | 0 | None | - | 1 | Human | 9.8 | pEC50 | = | 9.8 | Functional | ChEMBL | 603 | 8 | 2 | 7 | 5.1 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)C[C@@H]3CNC(=O)NC)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | ||
155526914 | 177981 | 0 | None | 2 | 2 | Human | 9.8 | pEC50 | = | 9.8 | Functional | ChEMBL | 1837 | 72 | 19 | 24 | 0.8 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
CHEMBL4459331 | 177981 | 0 | None | 2 | 2 | Human | 9.8 | pEC50 | = | 9.8 | Functional | ChEMBL | 1837 | 72 | 19 | 24 | 0.8 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
155559320 | 181643 | 0 | None | 1 | 2 | Human | 9.8 | pEC50 | = | 9.8 | Functional | ChEMBL | 1872 | 72 | 18 | 23 | 3.8 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
CHEMBL4563364 | 181643 | 0 | None | 1 | 2 | Human | 9.8 | pEC50 | = | 9.8 | Functional | ChEMBL | 1872 | 72 | 18 | 23 | 3.8 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
155533399 | 178624 | 0 | None | -2 | 2 | Human | 9.8 | pEC50 | = | 9.8 | Functional | ChEMBL | 1838 | 72 | 19 | 24 | 1.4 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
CHEMBL4468861 | 178624 | 0 | None | -2 | 2 | Human | 9.8 | pEC50 | = | 9.8 | Functional | ChEMBL | 1838 | 72 | 19 | 24 | 1.4 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
155535249 | 178782 | 0 | None | 2754 | 2 | Human | 9.8 | pEC50 | = | 9.8 | Functional | ChEMBL | 1808 | 68 | 16 | 23 | 2.0 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
CHEMBL4471373 | 178782 | 0 | None | 2754 | 2 | Human | 9.8 | pEC50 | = | 9.8 | Functional | ChEMBL | 1808 | 68 | 16 | 23 | 2.0 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
155535579 | 178829 | 0 | None | 158 | 2 | Human | 9.8 | pEC50 | = | 9.8 | Functional | ChEMBL | 1836 | 71 | 17 | 23 | 2.9 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
CHEMBL4471871 | 178829 | 0 | None | 158 | 2 | Human | 9.8 | pEC50 | = | 9.8 | Functional | ChEMBL | 1836 | 71 | 17 | 23 | 2.9 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
44562310 | 179432 | 0 | None | - | 1 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 602 | 8 | 1 | 7 | 5.7 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)C[C@@H]3C(=O)NC(C)C)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | ||
CHEMBL449681 | 179432 | 0 | None | - | 1 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 602 | 8 | 1 | 7 | 5.7 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)C[C@@H]3C(=O)NC(C)C)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | ||
155552556 | 180847 | 0 | None | - | 1 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 1792 | 67 | 16 | 22 | 1.9 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
CHEMBL4544208 | 180847 | 0 | None | - | 1 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 1792 | 67 | 16 | 22 | 1.9 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
51353551 | 24906 | 16 | None | 1 | 3 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 605 | 8 | 3 | 5 | 5.0 | CC(C)N(C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(C(=O)O)c2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1016/j.bmcl.2015.03.051 | ||
CHEMBL1269257 | 24906 | 16 | None | 1 | 3 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 605 | 8 | 3 | 5 | 5.0 | CC(C)N(C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(C(=O)O)c2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1016/j.bmcl.2015.03.051 | ||
155542488 | 179913 | 0 | None | - | 1 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 1820 | 69 | 16 | 22 | 2.6 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
CHEMBL4520976 | 179913 | 0 | None | - | 1 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 1820 | 69 | 16 | 22 | 2.6 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
54583298 | 68697 | 0 | None | - | 1 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 558 | 6 | 1 | 6 | 5.9 | COc1ccc(-c2cnc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2)cc1 | 10.1016/j.bmcl.2011.03.069 | ||
CHEMBL1774042 | 68697 | 0 | None | - | 1 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 558 | 6 | 1 | 6 | 5.9 | COc1ccc(-c2cnc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2)cc1 | 10.1016/j.bmcl.2011.03.069 | ||
44562308 | 179435 | 0 | None | - | 1 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 624 | 9 | 1 | 8 | 4.7 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)C[C@@H]3CNS(C)(=O)=O)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | ||
CHEMBL449725 | 179435 | 0 | None | - | 1 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 624 | 9 | 1 | 8 | 4.7 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)C[C@@H]3CNS(C)(=O)=O)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | ||
155514270 | 176649 | 0 | None | - | 1 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 1848 | 72 | 16 | 22 | 3.6 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1016/j.ejmech.2022.114214 | ||
CHEMBL4440419 | 176649 | 0 | None | - | 1 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 1848 | 72 | 16 | 22 | 3.6 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1016/j.ejmech.2022.114214 | ||
155514432 | 176644 | 0 | None | 1096 | 2 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 2121 | 86 | 19 | 27 | 2.3 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)[C@H](CCCCN)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
CHEMBL4440303 | 176644 | 0 | None | 1096 | 2 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 2121 | 86 | 19 | 27 | 2.3 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)[C@H](CCCCN)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
155551968 | 180796 | 0 | None | 9772 | 2 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 1793 | 69 | 16 | 20 | 4.5 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
CHEMBL4542927 | 180796 | 0 | None | 9772 | 2 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 1793 | 69 | 16 | 20 | 4.5 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
54583296 | 68688 | 0 | None | - | 1 | Human | 9.6 | pEC50 | = | 9.6 | Functional | ChEMBL | 533 | 5 | 0 | 6 | 5.8 | COc1ccc(-c2cnc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(C)cc2F)cc1 | 10.1016/j.bmcl.2011.03.069 | ||
CHEMBL1774033 | 68688 | 0 | None | - | 1 | Human | 9.6 | pEC50 | = | 9.6 | Functional | ChEMBL | 533 | 5 | 0 | 6 | 5.8 | COc1ccc(-c2cnc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(C)cc2F)cc1 | 10.1016/j.bmcl.2011.03.069 | ||
155540739 | 179286 | 0 | None | 3388 | 2 | Human | 9.6 | pEC50 | = | 9.6 | Functional | ChEMBL | 1907 | 74 | 17 | 24 | 2.5 | CCCC[C@H](NC(=O)[C@H](Cc1cc2ccccc2[nH]1)NC(=O)CNC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(C)=O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
CHEMBL4483457 | 179286 | 0 | None | 3388 | 2 | Human | 9.6 | pEC50 | = | 9.6 | Functional | ChEMBL | 1907 | 74 | 17 | 24 | 2.5 | CCCC[C@H](NC(=O)[C@H](Cc1cc2ccccc2[nH]1)NC(=O)CNC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(C)=O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
44578686 | 186152 | 0 | None | - | 1 | Human | 9.6 | pEC50 | = | 9.6 | Functional | ChEMBL | 521 | 6 | 0 | 6 | 5.6 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(F)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | ||
CHEMBL473865 | 186152 | 0 | None | - | 1 | Human | 9.6 | pEC50 | = | 9.6 | Functional | ChEMBL | 521 | 6 | 0 | 6 | 5.6 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(F)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | ||
44562305 | 195399 | 0 | None | - | 1 | Human | 9.6 | pEC50 | = | 9.6 | Functional | ChEMBL | 589 | 8 | 0 | 8 | 5.7 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)C[C@@H]3COC(C)=O)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | ||
CHEMBL502924 | 195399 | 0 | None | - | 1 | Human | 9.6 | pEC50 | = | 9.6 | Functional | ChEMBL | 589 | 8 | 0 | 8 | 5.7 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)C[C@@H]3COC(C)=O)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | ||
155514270 | 176649 | 0 | None | - | 1 | Human | 9.6 | pEC50 | = | 9.6 | Functional | ChEMBL | 1848 | 72 | 16 | 22 | 3.6 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
CHEMBL4440419 | 176649 | 0 | None | - | 1 | Human | 9.6 | pEC50 | = | 9.6 | Functional | ChEMBL | 1848 | 72 | 16 | 22 | 3.6 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
44578764 | 187591 | 0 | None | - | 1 | Human | 9.6 | pEC50 | = | 9.6 | Functional | ChEMBL | 535 | 4 | 0 | 7 | 5.0 | O=C(c1cn(-c2ccc3c(c2)OCCO3)c(-c2ccc(F)cc2)n1)N1CCN(c2cnc3ccccc3c2)CC1 | 10.1016/j.bmcl.2008.06.057 | ||
CHEMBL475679 | 187591 | 0 | None | - | 1 | Human | 9.6 | pEC50 | = | 9.6 | Functional | ChEMBL | 535 | 4 | 0 | 7 | 5.0 | O=C(c1cn(-c2ccc3c(c2)OCCO3)c(-c2ccc(F)cc2)n1)N1CCN(c2cnc3ccccc3c2)CC1 | 10.1016/j.bmcl.2008.06.057 | ||
46235271 | 80423 | 2 | None | 3 | 3 | Human | 9.5 | pEC50 | = | 9.5 | Functional | ChEMBL | 649 | 7 | 1 | 6 | 6.7 | Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1021/acs.jmedchem.5b01110 | ||
CHEMBL2017835 | 80423 | 2 | None | 3 | 3 | Human | 9.5 | pEC50 | = | 9.5 | Functional | ChEMBL | 649 | 7 | 1 | 6 | 6.7 | Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1021/acs.jmedchem.5b01110 | ||
155539345 | 179612 | 0 | None | 3235 | 2 | Human | 9.5 | pEC50 | = | 9.5 | Functional | ChEMBL | 1850 | 72 | 16 | 23 | 3.4 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
CHEMBL4514283 | 179612 | 0 | None | 3235 | 2 | Human | 9.5 | pEC50 | = | 9.5 | Functional | ChEMBL | 1850 | 72 | 16 | 23 | 3.4 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
155543163 | 180065 | 0 | None | 8709 | 2 | Human | 9.5 | pEC50 | = | 9.5 | Functional | ChEMBL | 1886 | 72 | 16 | 25 | 2.5 | CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
CHEMBL4525615 | 180065 | 0 | None | 8709 | 2 | Human | 9.5 | pEC50 | = | 9.5 | Functional | ChEMBL | 1886 | 72 | 16 | 25 | 2.5 | CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
24861060 | 195506 | 0 | None | -5 | 3 | Mouse | 9.5 | pEC50 | = | 9.5 | Functional | ChEMBL | 578 | 7 | 1 | 6 | 6.2 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2F)c1 | 10.1016/j.bmcl.2008.07.083 | ||
CHEMBL446789 | 195506 | 0 | None | -5 | 3 | Mouse | 9.5 | pEC50 | = | 9.5 | Functional | ChEMBL | 578 | 7 | 1 | 6 | 6.2 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2F)c1 | 10.1016/j.bmcl.2008.07.083 | ||
CHEMBL504861 | 195506 | 0 | None | -5 | 3 | Mouse | 9.5 | pEC50 | = | 9.5 | Functional | ChEMBL | 578 | 7 | 1 | 6 | 6.2 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2F)c1 | 10.1016/j.bmcl.2008.07.083 | ||
155517239 | 176936 | 0 | None | - | 1 | Human | 9.5 | pEC50 | = | 9.5 | Functional | ChEMBL | 2582 | 122 | 16 | 39 | 4.4 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
CHEMBL4444353 | 176936 | 0 | None | - | 1 | Human | 9.5 | pEC50 | = | 9.5 | Functional | ChEMBL | 2582 | 122 | 16 | 39 | 4.4 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
155547906 | 180455 | 0 | None | - | 1 | Human | 9.5 | pEC50 | = | 9.5 | Functional | ChEMBL | 1848 | 72 | 16 | 22 | 3.6 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)C[C@H](NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
CHEMBL4534977 | 180455 | 0 | None | - | 1 | Human | 9.5 | pEC50 | = | 9.5 | Functional | ChEMBL | 1848 | 72 | 16 | 22 | 3.6 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)C[C@H](NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
155546692 | 180421 | 0 | None | -3 | 2 | Human | 9.5 | pEC50 | = | 9.5 | Functional | ChEMBL | 1861 | 72 | 19 | 23 | 3.2 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
CHEMBL4534236 | 180421 | 0 | None | -3 | 2 | Human | 9.5 | pEC50 | = | 9.5 | Functional | ChEMBL | 1861 | 72 | 19 | 23 | 3.2 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
46235271 | 80423 | 2 | None | 3 | 3 | Human | 9.5 | pEC50 | = | 9.5 | Functional | ChEMBL | 649 | 7 | 1 | 6 | 6.7 | Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1021/acs.jmedchem.5b01110 | ||
CHEMBL2017835 | 80423 | 2 | None | 3 | 3 | Human | 9.5 | pEC50 | = | 9.5 | Functional | ChEMBL | 649 | 7 | 1 | 6 | 6.7 | Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1021/acs.jmedchem.5b01110 | ||
155515427 | 176728 | 0 | None | 1819 | 2 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 1886 | 72 | 17 | 23 | 4.2 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
CHEMBL4441596 | 176728 | 0 | None | 1819 | 2 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 1886 | 72 | 17 | 23 | 4.2 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
155566319 | 182519 | 0 | None | 4677 | 2 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 1850 | 71 | 16 | 23 | 3.2 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
CHEMBL4583158 | 182519 | 0 | None | 4677 | 2 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 1850 | 71 | 16 | 23 | 3.2 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
155543995 | 180102 | 0 | None | - | 1 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 1876 | 73 | 16 | 22 | 4.2 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
CHEMBL4526455 | 180102 | 0 | None | - | 1 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 1876 | 73 | 16 | 22 | 4.2 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
155548381 | 180511 | 0 | None | - | 1 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 1720 | 69 | 15 | 20 | 3.8 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)[C@@H](C)CC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
CHEMBL4536393 | 180511 | 0 | None | - | 1 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 1720 | 69 | 15 | 20 | 3.8 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)[C@@H](C)CC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
24861174 | 181386 | 0 | None | - | 1 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 546 | 6 | 1 | 6 | 5.7 | COc1cccc(-n2cc(C(=O)N3CCN(c4cc5ccccc5cc4C(=O)O)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | ||
CHEMBL455742 | 181386 | 0 | None | - | 1 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 546 | 6 | 1 | 6 | 5.7 | COc1cccc(-n2cc(C(=O)N3CCN(c4cc5ccccc5cc4C(=O)O)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | ||
155562281 | 182620 | 0 | None | 4168 | 2 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 1900 | 71 | 16 | 23 | 4.4 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1cccc2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
CHEMBL4585323 | 182620 | 0 | None | 4168 | 2 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 1900 | 71 | 16 | 23 | 4.4 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1cccc2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
155555065 | 181113 | 0 | None | 4168 | 2 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 1836 | 71 | 17 | 23 | 2.9 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
CHEMBL4550876 | 181113 | 0 | None | 4168 | 2 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 1836 | 71 | 17 | 23 | 2.9 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
44562313 | 179237 | 0 | None | - | 1 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 624 | 9 | 1 | 8 | 4.7 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)C[C@H]3CNS(C)(=O)=O)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | ||
CHEMBL448118 | 179237 | 0 | None | - | 1 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 624 | 9 | 1 | 8 | 4.7 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)C[C@H]3CNS(C)(=O)=O)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | ||
46235271 | 80423 | 2 | None | 3 | 3 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 649 | 7 | 1 | 6 | 6.7 | Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1021/acs.jmedchem.5b01110 | ||
CHEMBL2017835 | 80423 | 2 | None | 3 | 3 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 649 | 7 | 1 | 6 | 6.7 | Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1021/acs.jmedchem.5b01110 | ||
44562306 | 195708 | 0 | None | -8 | 2 | Mouse | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 605 | 10 | 1 | 8 | 5.2 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)C[C@@H]3COCC(=O)O)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | ||
CHEMBL508004 | 195708 | 0 | None | -8 | 2 | Mouse | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 605 | 10 | 1 | 8 | 5.2 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)C[C@@H]3COCC(=O)O)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | ||
155517761 | 177002 | 0 | None | 416 | 2 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 1900 | 71 | 16 | 23 | 4.4 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1cccc2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
CHEMBL4445529 | 177002 | 0 | None | 416 | 2 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 1900 | 71 | 16 | 23 | 4.4 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1cccc2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
155560670 | 181871 | 0 | None | 72 | 2 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 1886 | 72 | 17 | 23 | 4.2 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
CHEMBL4568746 | 181871 | 0 | None | 72 | 2 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 1886 | 72 | 17 | 23 | 4.2 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
155568312 | 182857 | 0 | None | 36 | 2 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 1836 | 72 | 17 | 23 | 3.0 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
CHEMBL4591101 | 182857 | 0 | None | 36 | 2 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 1836 | 72 | 17 | 23 | 3.0 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
52949124 | 7663 | 4 | None | 2 | 3 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | ||
9055 | 7663 | 4 | None | 2 | 3 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | ||
CHEMBL1269258 | 7663 | 4 | None | 2 | 3 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | ||
DB12694 | 7663 | 4 | None | 2 | 3 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | ||
44578727 | 196529 | 0 | None | - | 1 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 521 | 6 | 0 | 6 | 5.6 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccccc2F)c1 | 10.1016/j.bmcl.2008.06.057 | ||
CHEMBL515887 | 196529 | 0 | None | - | 1 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 521 | 6 | 0 | 6 | 5.6 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccccc2F)c1 | 10.1016/j.bmcl.2008.06.057 | ||
46869398 | 68698 | 0 | None | -5 | 3 | Mouse | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 576 | 6 | 1 | 6 | 6.1 | COc1ccc(-c2cnc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2F)cc1 | 10.1016/j.bmcl.2011.03.069 | ||
CHEMBL1774043 | 68698 | 0 | None | -5 | 3 | Mouse | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 576 | 6 | 1 | 6 | 6.1 | COc1ccc(-c2cnc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2F)cc1 | 10.1016/j.bmcl.2011.03.069 | ||
54580295 | 68687 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 519 | 5 | 0 | 6 | 5.5 | COc1ccc(-c2cnc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccccc2F)cc1 | 10.1016/j.bmcl.2011.03.069 | ||
CHEMBL1774032 | 68687 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 519 | 5 | 0 | 6 | 5.5 | COc1ccc(-c2cnc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccccc2F)cc1 | 10.1016/j.bmcl.2011.03.069 | ||
155532759 | 178534 | 0 | None | 27542 | 2 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 1431 | 50 | 12 | 15 | 5.6 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
CHEMBL4467402 | 178534 | 0 | None | 27542 | 2 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 1431 | 50 | 12 | 15 | 5.6 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
44578767 | 180295 | 0 | None | 3 | 2 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 517 | 6 | 0 | 6 | 5.8 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | ||
CHEMBL453083 | 180295 | 0 | None | 3 | 2 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 517 | 6 | 0 | 6 | 5.8 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | ||
CHEMBL503822 | 180295 | 0 | None | 3 | 2 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 517 | 6 | 0 | 6 | 5.8 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | ||
44578767 | 180295 | 0 | None | 3 | 2 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 517 | 6 | 0 | 6 | 5.8 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | ||
CHEMBL453083 | 180295 | 0 | None | 3 | 2 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 517 | 6 | 0 | 6 | 5.8 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | ||
CHEMBL503822 | 180295 | 0 | None | 3 | 2 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 517 | 6 | 0 | 6 | 5.8 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | ||
54586148 | 68642 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 543 | 4 | 0 | 7 | 5.4 | Cc1ccc(-c2nc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)ncc2-c2ccc3c(c2)OCCO3)cc1 | 10.1016/j.bmcl.2011.03.069 | ||
CHEMBL1773891 | 68642 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 543 | 4 | 0 | 7 | 5.4 | Cc1ccc(-c2nc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)ncc2-c2ccc3c(c2)OCCO3)cc1 | 10.1016/j.bmcl.2011.03.069 | ||
44562311 | 195497 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 589 | 8 | 0 | 8 | 5.7 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)C[C@H]3COC(C)=O)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | ||
CHEMBL504707 | 195497 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 589 | 8 | 0 | 8 | 5.7 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)C[C@H]3COC(C)=O)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | ||
51353551 | 24906 | 16 | None | 1 | 3 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 605 | 8 | 3 | 5 | 5.0 | CC(C)N(C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(C(=O)O)c2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1016/j.bmcl.2015.03.051 | ||
CHEMBL1269257 | 24906 | 16 | None | 1 | 3 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 605 | 8 | 3 | 5 | 5.0 | CC(C)N(C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(C(=O)O)c2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1016/j.bmcl.2015.03.051 | ||
168277247 | 197488 | 0 | None | -12 | 2 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 5585 | 206 | 67 | 76 | -9.8 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)[C@@H](C)O)[C@@H](C)CC)[C@@H](C)CC)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1016/j.ejmech.2022.114214 | ||
CHEMBL5182331 | 197488 | 0 | None | -12 | 2 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 5585 | 206 | 67 | 76 | -9.8 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)[C@@H](C)O)[C@@H](C)CC)[C@@H](C)CC)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1016/j.ejmech.2022.114214 | ||
168281017 | 197693 | 0 | None | -10 | 2 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 4869 | 167 | 62 | 67 | -13.0 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)[C@@H](C)O)[C@@H](C)CC)[C@@H](C)CC)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1016/j.ejmech.2022.114214 | ||
CHEMBL5185239 | 197693 | 0 | None | -10 | 2 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 4869 | 167 | 62 | 67 | -13.0 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)[C@@H](C)O)[C@@H](C)CC)[C@@H](C)CC)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1016/j.ejmech.2022.114214 | ||
155543846 | 179991 | 0 | None | -14 | 2 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 1838 | 72 | 19 | 24 | 2.4 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
CHEMBL4522865 | 179991 | 0 | None | -14 | 2 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 1838 | 72 | 19 | 24 | 2.4 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
24785705 | 189065 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 530 | 4 | 0 | 6 | 5.7 | Cc1ccc(-c2nc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)cn2-c2ccc3c(c2)OCCO3)cc1 | 10.1016/j.bmcl.2008.06.057 | ||
CHEMBL478398 | 189065 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 530 | 4 | 0 | 6 | 5.7 | Cc1ccc(-c2nc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)cn2-c2ccc3c(c2)OCCO3)cc1 | 10.1016/j.bmcl.2008.06.057 | ||
168280134 | 197520 | 0 | None | -3 | 2 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 5585 | 206 | 67 | 76 | -9.8 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)[C@@H](C)O)[C@@H](C)CC)[C@@H](C)CC)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1016/j.ejmech.2022.114214 | ||
CHEMBL5182775 | 197520 | 0 | None | -3 | 2 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 5585 | 206 | 67 | 76 | -9.8 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)[C@@H](C)O)[C@@H](C)CC)[C@@H](C)CC)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1016/j.ejmech.2022.114214 | ||
16755782 | 186130 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 538 | 6 | 0 | 5 | 6.3 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2ccc(F)cc2F)c1 | 10.1016/j.bmcl.2008.06.057 | ||
CHEMBL473663 | 186130 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 538 | 6 | 0 | 5 | 6.3 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2ccc(F)cc2F)c1 | 10.1016/j.bmcl.2008.06.057 | ||
44578424 | 189705 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 503 | 5 | 0 | 6 | 5.4 | COc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | ||
CHEMBL479256 | 189705 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 503 | 5 | 0 | 6 | 5.4 | COc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | ||
155540394 | 179715 | 0 | None | 58 | 2 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 1820 | 69 | 17 | 23 | 2.7 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
CHEMBL4516794 | 179715 | 0 | None | 58 | 2 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 1820 | 69 | 17 | 23 | 2.7 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
168273900 | 197477 | 0 | None | -7 | 2 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 4701 | 158 | 61 | 64 | -14.6 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)CC)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1016/j.ejmech.2022.114214 | ||
CHEMBL5182173 | 197477 | 0 | None | -7 | 2 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 4701 | 158 | 61 | 64 | -14.6 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)CC)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1016/j.ejmech.2022.114214 | ||
168277239 | 197487 | 0 | None | -2 | 2 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 5417 | 197 | 66 | 73 | -11.4 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)CC)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1016/j.ejmech.2022.114214 | ||
CHEMBL5182323 | 197487 | 0 | None | -2 | 2 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 5417 | 197 | 66 | 73 | -11.4 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)CC)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1016/j.ejmech.2022.114214 | ||
CHEMBL409529 | 219546 | 2 | None | 11 | 2 | Guinea pig | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00093a013 | ||||
168276807 | 197415 | 0 | None | -9 | 2 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 5417 | 197 | 66 | 73 | -11.4 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)CC)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1016/j.ejmech.2022.114214 | ||
CHEMBL5181266 | 197415 | 0 | None | -9 | 2 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 5417 | 197 | 66 | 73 | -11.4 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)CC)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1016/j.ejmech.2022.114214 | ||
54587150 | 68638 | 0 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 515 | 5 | 0 | 6 | 5.6 | COc1ccc(-c2cnc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)cc1 | 10.1016/j.bmcl.2011.03.069 | ||
CHEMBL1773887 | 68638 | 0 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 515 | 5 | 0 | 6 | 5.6 | COc1ccc(-c2cnc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)cc1 | 10.1016/j.bmcl.2011.03.069 | ||
16755781 | 195564 | 12 | None | -12 | 3 | Mouse | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 560 | 7 | 1 | 6 | 6.1 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | ||
CHEMBL443189 | 195564 | 12 | None | -12 | 3 | Mouse | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 560 | 7 | 1 | 6 | 6.1 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | ||
CHEMBL505409 | 195564 | 12 | None | -12 | 3 | Mouse | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 560 | 7 | 1 | 6 | 6.1 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | ||
CHEMBL505727 | 195564 | 12 | None | -12 | 3 | Mouse | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 560 | 7 | 1 | 6 | 6.1 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | ||
52949124 | 7663 | 4 | None | 2 | 3 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | ||
9055 | 7663 | 4 | None | 2 | 3 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | ||
CHEMBL1269258 | 7663 | 4 | None | 2 | 3 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | ||
DB12694 | 7663 | 4 | None | 2 | 3 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | ||
CHEMBL414592 | 219924 | 0 | None | 8 | 2 | Guinea pig | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)N(C)C(=O)[C@H](CC(=O)O)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00093a013 | ||||
52949124 | 7663 | 4 | None | 2 | 3 | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | ||
9055 | 7663 | 4 | None | 2 | 3 | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | ||
CHEMBL1269258 | 7663 | 4 | None | 2 | 3 | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | ||
DB12694 | 7663 | 4 | None | 2 | 3 | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | ||
10700916 | 181215 | 0 | None | - | 1 | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 896 | 26 | 9 | 9 | 2.1 | CCCC[C@H](NC(=O)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
CHEMBL4553223 | 181215 | 0 | None | - | 1 | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 896 | 26 | 9 | 9 | 2.1 | CCCC[C@H](NC(=O)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
155550911 | 180707 | 0 | None | - | 1 | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 1884 | 70 | 16 | 23 | 3.3 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
CHEMBL4540877 | 180707 | 0 | None | - | 1 | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 1884 | 70 | 16 | 23 | 3.3 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
54583260 | 68647 | 0 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 519 | 5 | 0 | 6 | 5.5 | COc1ccc(-c2cnc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(F)cc2)cc1 | 10.1016/j.bmcl.2011.03.069 | ||
CHEMBL1773896 | 68647 | 0 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 519 | 5 | 0 | 6 | 5.5 | COc1ccc(-c2cnc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(F)cc2)cc1 | 10.1016/j.bmcl.2011.03.069 | ||
52949124 | 7663 | 4 | None | 2 | 3 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | ||
9055 | 7663 | 4 | None | 2 | 3 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | ||
CHEMBL1269258 | 7663 | 4 | None | 2 | 3 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | ||
DB12694 | 7663 | 4 | None | 2 | 3 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | ||
24785703 | 186131 | 0 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 534 | 6 | 0 | 5 | 6.5 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2ccc(C)cc2F)c1 | 10.1016/j.bmcl.2008.06.057 | ||
CHEMBL473664 | 186131 | 0 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 534 | 6 | 0 | 5 | 6.5 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2ccc(C)cc2F)c1 | 10.1016/j.bmcl.2008.06.057 | ||
54586175 | 68692 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 504 | 5 | 0 | 6 | 5.8 | COc1ccc(-c2cnc(C(=O)N3CCN(c4ccc5ccoc5c4)CC3)nc2-c2ccc(C)cc2)cc1 | 10.1016/j.bmcl.2011.03.069 | ||
CHEMBL1774037 | 68692 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 504 | 5 | 0 | 6 | 5.8 | COc1ccc(-c2cnc(C(=O)N3CCN(c4ccc5ccoc5c4)CC3)nc2-c2ccc(C)cc2)cc1 | 10.1016/j.bmcl.2011.03.069 | ||
44578611 | 196437 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 520 | 6 | 0 | 5 | 6.2 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2cccc(F)c2)c1 | 10.1016/j.bmcl.2008.06.057 | ||
CHEMBL515160 | 196437 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 520 | 6 | 0 | 5 | 6.2 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2cccc(F)c2)c1 | 10.1016/j.bmcl.2008.06.057 | ||
44578456 | 196375 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 503 | 5 | 0 | 6 | 5.4 | COc1cccc(-n2cc(C(=O)N3CCN(c4ccc5cnccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | ||
CHEMBL514716 | 196375 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 503 | 5 | 0 | 6 | 5.4 | COc1cccc(-n2cc(C(=O)N3CCN(c4ccc5cnccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | ||
155531277 | 178410 | 0 | None | 2 | 2 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 1821 | 72 | 18 | 23 | 2.1 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
CHEMBL4465747 | 178410 | 0 | None | 2 | 2 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 1821 | 72 | 18 | 23 | 2.1 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
155553502 | 180954 | 0 | None | -26 | 2 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 1822 | 72 | 19 | 22 | 3.0 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OP(=O)(O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
CHEMBL4547294 | 180954 | 0 | None | -26 | 2 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 1822 | 72 | 19 | 22 | 3.0 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OP(=O)(O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
155564367 | 181935 | 0 | None | -457 | 2 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 1836 | 72 | 18 | 23 | 2.9 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
CHEMBL4570130 | 181935 | 0 | None | -457 | 2 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 1836 | 72 | 18 | 23 | 2.9 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
70691750 | 80421 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 621 | 7 | 1 | 6 | 6.1 | O=C1[C@@H](Cc2n[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc2N1CC(=O)N1CCCCC1Cc1ccccc1 | 10.1016/j.bmcl.2012.02.049 | ||
CHEMBL2017833 | 80421 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 621 | 7 | 1 | 6 | 6.1 | O=C1[C@@H](Cc2n[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc2N1CC(=O)N1CCCCC1Cc1ccccc1 | 10.1016/j.bmcl.2012.02.049 | ||
52949124 | 7663 | 4 | None | 2 | 3 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1016/j.bmcl.2012.02.049 | ||
9055 | 7663 | 4 | None | 2 | 3 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1016/j.bmcl.2012.02.049 | ||
CHEMBL1269258 | 7663 | 4 | None | 2 | 3 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1016/j.bmcl.2012.02.049 | ||
DB12694 | 7663 | 4 | None | 2 | 3 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1016/j.bmcl.2012.02.049 | ||
10507109 | 116004 | 0 | None | -51 | 4 | Guinea pig | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 561 | 7 | 2 | 4 | 5.3 | CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1016/j.bmc.2007.12.047 | ||
CHEMBL321761 | 116004 | 0 | None | -51 | 4 | Guinea pig | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 561 | 7 | 2 | 4 | 5.3 | CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1016/j.bmc.2007.12.047 | ||
70683295 | 80371 | 0 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 606 | 7 | 1 | 5 | 6.2 | O=C(CN1C(=O)C(Cc2c[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc21)N1CCC(Cc2ccccc2)C1 | 10.1016/j.bmcl.2012.02.049 | ||
CHEMBL2017692 | 80371 | 0 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 606 | 7 | 1 | 5 | 6.2 | O=C(CN1C(=O)C(Cc2c[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc21)N1CCC(Cc2ccccc2)C1 | 10.1016/j.bmcl.2012.02.049 | ||
44578531 | 179341 | 0 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 570 | 6 | 0 | 5 | 6.9 | Cc1ccc(-c2nc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)cn2-c2cccc(OCC(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2008.06.057 | ||
CHEMBL448597 | 179341 | 0 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 570 | 6 | 0 | 5 | 6.9 | Cc1ccc(-c2nc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)cn2-c2cccc(OCC(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2008.06.057 | ||
11571172 | 147362 | 0 | None | - | 1 | Rat | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 695 | 10 | 2 | 6 | 6.6 | COc1ccc(N(C(=O)CN2C(=O)[C@H](NC(=O)Nc3cccc(C(=O)c4ccccc4)c3)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm049072h | ||
CHEMBL381347 | 147362 | 0 | None | - | 1 | Rat | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 695 | 10 | 2 | 6 | 6.6 | COc1ccc(N(C(=O)CN2C(=O)[C@H](NC(=O)Nc3cccc(C(=O)c4ccccc4)c3)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm049072h | ||
52944224 | 24907 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 586 | 8 | 2 | 7 | 5.6 | CC(C)N(C(=O)CN1C(=O)C(Nc2cccc(C(=O)O)c2)c2nnc(-c3ccccc3)n2-c2ccccc21)c1ccccc1 | 10.1016/j.bmcl.2010.08.115 | ||
CHEMBL1269259 | 24907 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 586 | 8 | 2 | 7 | 5.6 | CC(C)N(C(=O)CN1C(=O)C(Nc2cccc(C(=O)O)c2)c2nnc(-c3ccccc3)n2-c2ccccc21)c1ccccc1 | 10.1016/j.bmcl.2010.08.115 | ||
70685411 | 80412 | 0 | None | - | 1 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 606 | 6 | 1 | 5 | 6.8 | O=C1C(Cc2c[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc2N1CC(=O)N1CCCCC1c1ccccc1 | 10.1016/j.bmcl.2012.02.049 | ||
CHEMBL2017824 | 80412 | 0 | None | - | 1 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 606 | 6 | 1 | 5 | 6.8 | O=C1C(Cc2c[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc2N1CC(=O)N1CCCCC1c1ccccc1 | 10.1016/j.bmcl.2012.02.049 | ||
54580296 | 68690 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 515 | 5 | 0 | 6 | 5.6 | COc1ccc(-c2cnc(C(=O)N3CCN(c4cc5ccccc5cn4)CC3)nc2-c2ccc(C)cc2)cc1 | 10.1016/j.bmcl.2011.03.069 | ||
CHEMBL1774035 | 68690 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 515 | 5 | 0 | 6 | 5.6 | COc1ccc(-c2cnc(C(=O)N3CCN(c4cc5ccccc5cn4)CC3)nc2-c2ccc(C)cc2)cc1 | 10.1016/j.bmcl.2011.03.069 | ||
24785432 | 188340 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 530 | 7 | 0 | 5 | 6.6 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2ccc(CC)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | ||
CHEMBL476725 | 188340 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 530 | 7 | 0 | 5 | 6.6 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2ccc(CC)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | ||
52945789 | 25056 | 0 | None | - | 1 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 541 | 7 | 0 | 5 | 6.0 | CC(C)N(C(=O)CN1C(=O)C(Cc2ccccc2)c2nnc(-c3ccccc3)n2-c2ccccc21)c1ccccc1 | 10.1016/j.bmcl.2010.08.115 | ||
CHEMBL1270487 | 25056 | 0 | None | - | 1 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 541 | 7 | 0 | 5 | 6.0 | CC(C)N(C(=O)CN1C(=O)C(Cc2ccccc2)c2nnc(-c3ccccc3)n2-c2ccccc21)c1ccccc1 | 10.1016/j.bmcl.2010.08.115 | ||
54586149 | 68645 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 515 | 5 | 0 | 6 | 5.6 | COc1ccc(-c2cnc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2cccc(C)c2)cc1 | 10.1016/j.bmcl.2011.03.069 | ||
CHEMBL1773894 | 68645 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 515 | 5 | 0 | 6 | 5.6 | COc1ccc(-c2cnc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2cccc(C)c2)cc1 | 10.1016/j.bmcl.2011.03.069 | ||
CHEMBL217236 | 216151 | 0 | None | 4 | 2 | Guinea pig | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00093a013 | ||||
46235272 | 80420 | 0 | None | - | 1 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 589 | 8 | 1 | 7 | 4.9 | COCCC1CCCCN1C(=O)CN1C(=O)[C@@H](Cc2n[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc21 | 10.1016/j.bmcl.2012.02.049 | ||
CHEMBL2017832 | 80420 | 0 | None | - | 1 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 589 | 8 | 1 | 7 | 4.9 | COCCC1CCCCN1C(=O)CN1C(=O)[C@@H](Cc2n[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc21 | 10.1016/j.bmcl.2012.02.049 | ||
24785178 | 188318 | 0 | None | - | 1 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 520 | 6 | 0 | 5 | 6.2 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2ccc(F)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | ||
CHEMBL476530 | 188318 | 0 | None | - | 1 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 520 | 6 | 0 | 5 | 6.2 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2ccc(F)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | ||
24785177 | 196560 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 502 | 5 | 0 | 5 | 6.0 | COc1ccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)cc1 | 10.1016/j.bmcl.2008.06.057 | ||
CHEMBL516113 | 196560 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 502 | 5 | 0 | 5 | 6.0 | COc1ccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)cc1 | 10.1016/j.bmcl.2008.06.057 | ||
CHEMBL266839 | 217483 | 0 | None | 7 | 2 | Guinea pig | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00093a013 | ||||
54580266 | 68639 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 529 | 6 | 0 | 6 | 6.0 | CCOc1ccc(-c2cnc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)cc1 | 10.1016/j.bmcl.2011.03.069 | ||
CHEMBL1773888 | 68639 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 529 | 6 | 0 | 6 | 6.0 | CCOc1ccc(-c2cnc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)cc1 | 10.1016/j.bmcl.2011.03.069 | ||
70689619 | 80413 | 0 | None | - | 1 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 592 | 6 | 1 | 5 | 6.5 | O=C1C(Cc2c[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc2N1CC(=O)N1CCCC1c1ccccc1 | 10.1016/j.bmcl.2012.02.049 | ||
CHEMBL2017825 | 80413 | 0 | None | - | 1 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 592 | 6 | 1 | 5 | 6.5 | O=C1C(Cc2c[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc2N1CC(=O)N1CCCC1c1ccccc1 | 10.1016/j.bmcl.2012.02.049 | ||
155557285 | 181297 | 0 | None | -295 | 2 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 1779 | 74 | 19 | 22 | 1.6 | CCCC[C@H](NC(=O)[C@H](CNC(=O)CCCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
CHEMBL4555341 | 181297 | 0 | None | -295 | 2 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 1779 | 74 | 19 | 22 | 1.6 | CCCC[C@H](NC(=O)[C@H](CNC(=O)CCCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
155553269 | 180906 | 0 | None | 53 | 2 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 1818 | 68 | 15 | 22 | 3.9 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N1CCC[C@@H]1C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
CHEMBL4545970 | 180906 | 0 | None | 53 | 2 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 1818 | 68 | 15 | 22 | 3.9 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N1CCC[C@@H]1C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
44578305 | 187949 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 520 | 5 | 0 | 5 | 6.1 | COc1cccc(-n2cc(C(=O)N3CCN(c4ccc(Cl)c(Cl)c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | ||
CHEMBL476095 | 187949 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 520 | 5 | 0 | 5 | 6.1 | COc1cccc(-n2cc(C(=O)N3CCN(c4ccc(Cl)c(Cl)c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | ||
46235271 | 80423 | 2 | None | 3 | 3 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 649 | 7 | 1 | 6 | 6.7 | Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1016/j.bmcl.2012.02.049 | ||
CHEMBL2017835 | 80423 | 2 | None | 3 | 3 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 649 | 7 | 1 | 6 | 6.7 | Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1016/j.bmcl.2012.02.049 | ||
CHEMBL208479 | 215978 | 0 | None | -30 | 5 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](CCCC)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm050921q | ||||
CHEMBL208479 | 215978 | 0 | None | -30 | 5 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](CCCC)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm050921q | ||||
46234969 | 80416 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 626 | 7 | 1 | 5 | 7.4 | O=C1C(Cc2c[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc2N1CC(=O)N1CCCCC1CC1CCCCC1 | 10.1016/j.bmcl.2012.02.049 | ||
CHEMBL2017828 | 80416 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 626 | 7 | 1 | 5 | 7.4 | O=C1C(Cc2c[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc2N1CC(=O)N1CCCCC1CC1CCCCC1 | 10.1016/j.bmcl.2012.02.049 | ||
54587151 | 68640 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 545 | 6 | 0 | 7 | 5.6 | COc1ccc(-c2cnc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)cc1OC | 10.1016/j.bmcl.2011.03.069 | ||
CHEMBL1773889 | 68640 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 545 | 6 | 0 | 7 | 5.6 | COc1ccc(-c2cnc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)cc1OC | 10.1016/j.bmcl.2011.03.069 | ||
101823779 | 8178 | 35 | None | -354 | 2 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b01558 | ||||
16162108 | 8178 | 35 | None | -354 | 2 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b01558 | ||||
8408 | 8178 | 35 | None | -354 | 2 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b01558 | ||||
CHEMBL4451154 | 8178 | 35 | None | -354 | 2 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b01558 | ||||
54586174 | 68689 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 514 | 5 | 0 | 5 | 6.2 | COc1ccc(-c2cnc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)cc1 | 10.1016/j.bmcl.2011.03.069 | ||
CHEMBL1774034 | 68689 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 514 | 5 | 0 | 5 | 6.2 | COc1ccc(-c2cnc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)cc1 | 10.1016/j.bmcl.2011.03.069 | ||
CHEMBL375360 | 218997 | 4 | None | -1 | 2 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm061268p | ||||
4627 | 7609 | 50 | None | -1 | 6 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | None | None | None | None | 10.1021/jm050921q | ||||
864 | 7609 | 50 | None | -1 | 6 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | None | None | None | None | 10.1021/jm050921q | ||||
9833444 | 7609 | 50 | None | -1 | 6 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | None | None | None | None | 10.1021/jm050921q | ||||
CHEMBL1121 | 7609 | 50 | None | -1 | 6 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | None | None | None | None | 10.1021/jm050921q | ||||
DB09142 | 7609 | 50 | None | -1 | 6 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | None | None | None | None | 10.1021/jm050921q | ||||
4627 | 7609 | 50 | None | -1 | 6 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | None | None | None | None | 10.1021/jm050921q | ||||
864 | 7609 | 50 | None | -1 | 6 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | None | None | None | None | 10.1021/jm050921q | ||||
9833444 | 7609 | 50 | None | -1 | 6 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | None | None | None | None | 10.1021/jm050921q | ||||
CHEMBL1121 | 7609 | 50 | None | -1 | 6 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | None | None | None | None | 10.1021/jm050921q | ||||
DB09142 | 7609 | 50 | None | -1 | 6 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | None | None | None | None | 10.1021/jm050921q | ||||
51353551 | 24906 | 16 | None | 1 | 3 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 605 | 8 | 3 | 5 | 5.0 | CC(C)N(C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(C(=O)O)c2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1016/j.bmcl.2010.08.115 | ||
CHEMBL1269257 | 24906 | 16 | None | 1 | 3 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 605 | 8 | 3 | 5 | 5.0 | CC(C)N(C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(C(=O)O)c2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1016/j.bmcl.2010.08.115 | ||
54580265 | 68635 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 515 | 5 | 0 | 6 | 5.6 | COc1ccccc1-c1cnc(C(=O)N2CCN(c3cnc4ccccc4c3)CC2)nc1-c1ccc(C)cc1 | 10.1016/j.bmcl.2011.03.069 | ||
CHEMBL1773884 | 68635 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 515 | 5 | 0 | 6 | 5.6 | COc1ccccc1-c1cnc(C(=O)N2CCN(c3cnc4ccccc4c3)CC2)nc1-c1ccc(C)cc1 | 10.1016/j.bmcl.2011.03.069 | ||
52942901 | 24909 | 0 | None | 1 | 2 | Rat | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 556 | 8 | 1 | 6 | 5.9 | CC(C)N(Cc1ccccc1)C(=O)CN1C(=O)C(Nc2ccccc2)c2nnc(-c3ccccc3)n2-c2ccccc21 | 10.1016/j.bmcl.2010.08.115 | ||
CHEMBL1269261 | 24909 | 0 | None | 1 | 2 | Rat | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 556 | 8 | 1 | 6 | 5.9 | CC(C)N(Cc1ccccc1)C(=O)CN1C(=O)C(Nc2ccccc2)c2nnc(-c3ccccc3)n2-c2ccccc21 | 10.1016/j.bmcl.2010.08.115 | ||
CHEMBL382051 | 219072 | 0 | None | -331 | 5 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm050921q | ||||
CHEMBL217609 | 216158 | 0 | None | 6 | 2 | Guinea pig | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00093a013 | ||||
46235271 | 80423 | 2 | None | 3 | 3 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 649 | 7 | 1 | 6 | 6.7 | Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1021/acs.jmedchem.5b01110 | ||
CHEMBL2017835 | 80423 | 2 | None | 3 | 3 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 649 | 7 | 1 | 6 | 6.7 | Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1021/acs.jmedchem.5b01110 | ||
155542545 | 179898 | 0 | None | - | 1 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 1770 | 70 | 16 | 21 | 3.9 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
CHEMBL4520699 | 179898 | 0 | None | - | 1 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 1770 | 70 | 16 | 21 | 3.9 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
CHEMBL382051 | 219072 | 0 | None | -331 | 5 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm050921q | ||||
44578772 | 189575 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 486 | 5 | 0 | 5 | 5.5 | COc1cccc(-c2cc(C(=O)N3CCN(c4cccc(Cl)c4)CC3)nn2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | ||
CHEMBL479063 | 189575 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 486 | 5 | 0 | 5 | 5.5 | COc1cccc(-c2cc(C(=O)N3CCN(c4cccc(Cl)c4)CC3)nn2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | ||
70681224 | 80417 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 621 | 7 | 1 | 6 | 6.1 | O=C1C(Cc2c[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc2N1CC(=O)N1CCCCC1Cc1ccccn1 | 10.1016/j.bmcl.2012.02.049 | ||
CHEMBL2017829 | 80417 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 621 | 7 | 1 | 6 | 6.1 | O=C1C(Cc2c[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc2N1CC(=O)N1CCCCC1Cc1ccccn1 | 10.1016/j.bmcl.2012.02.049 | ||
52949124 | 7663 | 4 | None | 2 | 3 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1016/j.bmcl.2010.08.115 | ||
9055 | 7663 | 4 | None | 2 | 3 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1016/j.bmcl.2010.08.115 | ||
CHEMBL1269258 | 7663 | 4 | None | 2 | 3 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1016/j.bmcl.2010.08.115 | ||
DB12694 | 7663 | 4 | None | 2 | 3 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1016/j.bmcl.2010.08.115 | ||
44578530 | 195465 | 0 | None | - | 1 | Human | 5.5 | pEC50 | = | 5.5 | Functional | ChEMBL | 556 | 5 | 0 | 5 | 6.9 | Cc1ccc(-c2nc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)cn2-c2cccc(OC(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2008.06.057 | ||
CHEMBL504024 | 195465 | 0 | None | - | 1 | Human | 5.5 | pEC50 | = | 5.5 | Functional | ChEMBL | 556 | 5 | 0 | 5 | 6.9 | Cc1ccc(-c2nc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)cn2-c2cccc(OC(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2008.06.057 | ||
54581261 | 68637 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 529 | 6 | 0 | 6 | 6.0 | CCOc1cccc(-c2cnc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2011.03.069 | ||
CHEMBL1773886 | 68637 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 529 | 6 | 0 | 6 | 6.0 | CCOc1cccc(-c2cnc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2011.03.069 | ||
54582288 | 68644 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 515 | 5 | 0 | 6 | 5.6 | COc1ccc(-c2cnc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccccc2C)cc1 | 10.1016/j.bmcl.2011.03.069 | ||
CHEMBL1773893 | 68644 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 515 | 5 | 0 | 6 | 5.6 | COc1ccc(-c2cnc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccccc2C)cc1 | 10.1016/j.bmcl.2011.03.069 | ||
54580263 | 68631 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 519 | 5 | 0 | 6 | 5.5 | COc1ccc(-c2cnc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2cccc(F)c2)cc1 | 10.1016/j.bmcl.2011.03.069 | ||
CHEMBL1773878 | 68631 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 519 | 5 | 0 | 6 | 5.5 | COc1ccc(-c2cnc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2cccc(F)c2)cc1 | 10.1016/j.bmcl.2011.03.069 | ||
70695934 | 80419 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 595 | 8 | 1 | 6 | 5.9 | CC(C)N(Cc1ccccc1)C(=O)CN1C(=O)[C@@H](Cc2n[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc21 | 10.1016/j.bmcl.2012.02.049 | ||
CHEMBL2017831 | 80419 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 595 | 8 | 1 | 6 | 5.9 | CC(C)N(Cc1ccccc1)C(=O)CN1C(=O)[C@@H](Cc2n[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc21 | 10.1016/j.bmcl.2012.02.049 | ||
9960432 | 46198 | 5 | None | -3 | 3 | Guinea pig | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 605 | 8 | 3 | 5 | 5.0 | CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C(=O)O)c2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1016/j.bmc.2007.12.047 | ||
CHEMBL147186 | 46198 | 5 | None | -3 | 3 | Guinea pig | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 605 | 8 | 3 | 5 | 5.0 | CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C(=O)O)c2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1016/j.bmc.2007.12.047 | ||
10698109 | 114073 | 0 | None | -2 | 3 | Guinea pig | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 560 | 8 | 1 | 4 | 5.8 | CC(C)N(C(=O)CN1C(=O)C(CC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1016/j.bmc.2007.12.047 | ||
CHEMBL317181 | 114073 | 0 | None | -2 | 3 | Guinea pig | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 560 | 8 | 1 | 4 | 5.8 | CC(C)N(C(=O)CN1C(=O)C(CC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1016/j.bmc.2007.12.047 | ||
44578647 | 186107 | 0 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 538 | 6 | 0 | 5 | 6.3 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2c(F)cccc2F)c1 | 10.1016/j.bmcl.2008.06.057 | ||
CHEMBL473457 | 186107 | 0 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 538 | 6 | 0 | 5 | 6.3 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2c(F)cccc2F)c1 | 10.1016/j.bmcl.2008.06.057 | ||
70695922 | 80370 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 558 | 6 | 1 | 5 | 5.9 | CCC1CCCCN1C(=O)CN1C(=O)C(Cc2c[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc21 | 10.1016/j.bmcl.2012.02.049 | ||
CHEMBL2017691 | 80370 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 558 | 6 | 1 | 5 | 5.9 | CCC1CCCCN1C(=O)CN1C(=O)C(Cc2c[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc21 | 10.1016/j.bmcl.2012.02.049 | ||
54581301 | 68693 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 503 | 5 | 1 | 5 | 5.6 | COc1ccc(-c2cnc(C(=O)N3CCN(c4ccc5cc[nH]c5c4)CC3)nc2-c2ccc(C)cc2)cc1 | 10.1016/j.bmcl.2011.03.069 | ||
CHEMBL1774038 | 68693 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 503 | 5 | 1 | 5 | 5.6 | COc1ccc(-c2cnc(C(=O)N3CCN(c4ccc5cc[nH]c5c4)CC3)nc2-c2ccc(C)cc2)cc1 | 10.1016/j.bmcl.2011.03.069 | ||
52949124 | 7663 | 4 | None | 2 | 3 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | ||
9055 | 7663 | 4 | None | 2 | 3 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | ||
CHEMBL1269258 | 7663 | 4 | None | 2 | 3 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | ||
DB12694 | 7663 | 4 | None | 2 | 3 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | ||
54586147 | 68636 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 515 | 5 | 0 | 6 | 5.6 | COc1cccc(-c2cnc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2011.03.069 | ||
CHEMBL1773885 | 68636 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 515 | 5 | 0 | 6 | 5.6 | COc1cccc(-c2cnc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2011.03.069 | ||
70693814 | 80418 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 621 | 7 | 1 | 6 | 6.1 | O=C1C(Cc2c[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc2N1CC(=O)N1CCCCC1Cc1ccncc1 | 10.1016/j.bmcl.2012.02.049 | ||
CHEMBL2017830 | 80418 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 621 | 7 | 1 | 6 | 6.1 | O=C1C(Cc2c[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc2N1CC(=O)N1CCCCC1Cc1ccncc1 | 10.1016/j.bmcl.2012.02.049 | ||
52946666 | 24908 | 0 | None | 2 | 2 | Rat | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 600 | 9 | 2 | 7 | 5.6 | CC(C)N(Cc1ccccc1)C(=O)CN1C(=O)C(Nc2cccc(C(=O)O)c2)c2nnc(-c3ccccc3)n2-c2ccccc21 | 10.1016/j.bmcl.2010.08.115 | ||
CHEMBL1269260 | 24908 | 0 | None | 2 | 2 | Rat | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 600 | 9 | 2 | 7 | 5.6 | CC(C)N(Cc1ccccc1)C(=O)CN1C(=O)C(Nc2cccc(C(=O)O)c2)c2nnc(-c3ccccc3)n2-c2ccccc21 | 10.1016/j.bmcl.2010.08.115 | ||
44578422 | 188341 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 503 | 5 | 0 | 6 | 5.4 | COc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5n4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | ||
CHEMBL476739 | 188341 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 503 | 5 | 0 | 6 | 5.4 | COc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5n4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | ||
52949124 | 7663 | 4 | None | -2 | 3 | Rat | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1016/j.bmcl.2010.08.115 | ||
9055 | 7663 | 4 | None | -2 | 3 | Rat | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1016/j.bmcl.2010.08.115 | ||
CHEMBL1269258 | 7663 | 4 | None | -2 | 3 | Rat | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1016/j.bmcl.2010.08.115 | ||
DB12694 | 7663 | 4 | None | -2 | 3 | Rat | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1016/j.bmcl.2010.08.115 | ||
44578562 | 188313 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 530 | 4 | 0 | 6 | 5.7 | Cc1ccc(-c2nc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)cn2-c2cccc3c2OCCO3)cc1 | 10.1016/j.bmcl.2008.06.057 | ||
CHEMBL476519 | 188313 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 530 | 4 | 0 | 6 | 5.7 | Cc1ccc(-c2nc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)cn2-c2cccc3c2OCCO3)cc1 | 10.1016/j.bmcl.2008.06.057 | ||
52940616 | 24911 | 0 | None | 1 | 2 | Rat | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 581 | 7 | 1 | 6 | 5.7 | CC(C)N(Cc1ccccc1)C(=O)CN1C(=O)C(c2n[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc21 | 10.1016/j.bmcl.2010.08.115 | ||
CHEMBL1269263 | 24911 | 0 | None | 1 | 2 | Rat | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 581 | 7 | 1 | 6 | 5.7 | CC(C)N(Cc1ccccc1)C(=O)CN1C(=O)C(c2n[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc21 | 10.1016/j.bmcl.2010.08.115 | ||
46234820 | 80414 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 572 | 6 | 1 | 5 | 6.1 | CC(C)C1CCCCN1C(=O)CN1C(=O)C(Cc2c[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc21 | 10.1016/j.bmcl.2012.02.049 | ||
CHEMBL2017826 | 80414 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 572 | 6 | 1 | 5 | 6.1 | CC(C)C1CCCCN1C(=O)CN1C(=O)C(Cc2c[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc21 | 10.1016/j.bmcl.2012.02.049 | ||
46235271 | 80423 | 2 | None | 3 | 3 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 649 | 7 | 1 | 6 | 6.7 | Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1021/acs.jmedchem.5b01110 | ||
CHEMBL2017835 | 80423 | 2 | None | 3 | 3 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 649 | 7 | 1 | 6 | 6.7 | Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1021/acs.jmedchem.5b01110 | ||
24785180 | 188319 | 0 | None | - | 1 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 536 | 6 | 0 | 5 | 6.7 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2ccc(Cl)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | ||
CHEMBL476531 | 188319 | 0 | None | - | 1 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 536 | 6 | 0 | 5 | 6.7 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2ccc(Cl)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | ||
54582313 | 68694 | 0 | None | - | 1 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 572 | 6 | 0 | 7 | 6.0 | COC(=O)c1cc2ccccc2cc1N1CCN(C(=O)c2ncc(-c3ccc(OC)cc3)c(-c3ccc(C)cc3)n2)CC1 | 10.1016/j.bmcl.2011.03.069 | ||
CHEMBL1774039 | 68694 | 0 | None | - | 1 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 572 | 6 | 0 | 7 | 6.0 | COC(=O)c1cc2ccccc2cc1N1CCN(C(=O)c2ncc(-c3ccc(OC)cc3)c(-c3ccc(C)cc3)n2)CC1 | 10.1016/j.bmcl.2011.03.069 | ||
70689603 | 80369 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 588 | 8 | 1 | 6 | 5.5 | COCCC1CCCCN1C(=O)CN1C(=O)C(Cc2c[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc21 | 10.1016/j.bmcl.2012.02.049 | ||
CHEMBL2017690 | 80369 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 588 | 8 | 1 | 6 | 5.5 | COCCC1CCCCN1C(=O)CN1C(=O)C(Cc2c[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc21 | 10.1016/j.bmcl.2012.02.049 | ||
52940616 | 24911 | 0 | None | -1 | 2 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 581 | 7 | 1 | 6 | 5.7 | CC(C)N(Cc1ccccc1)C(=O)CN1C(=O)C(c2n[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc21 | 10.1016/j.bmcl.2010.08.115 | ||
CHEMBL1269263 | 24911 | 0 | None | -1 | 2 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 581 | 7 | 1 | 6 | 5.7 | CC(C)N(Cc1ccccc1)C(=O)CN1C(=O)C(c2n[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc21 | 10.1016/j.bmcl.2010.08.115 | ||
24785430 | 189063 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 530 | 6 | 0 | 5 | 6.8 | Cc1ccc(-c2nc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)cn2-c2cccc(OC(C)C)c2)cc1 | 10.1016/j.bmcl.2008.06.057 | ||
CHEMBL478397 | 189063 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 530 | 6 | 0 | 5 | 6.8 | Cc1ccc(-c2nc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)cn2-c2cccc(OC(C)C)c2)cc1 | 10.1016/j.bmcl.2008.06.057 | ||
CHEMBL269185 | 217559 | 0 | None | 5 | 2 | Guinea pig | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(C)=O)C(=O)NCC(=O)N(C)[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00093a013 | ||||
44578398 | 188563 | 0 | None | - | 1 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 502 | 5 | 0 | 5 | 6.0 | COc1cccc(-n2cc(C(=O)N3CCN(c4cccc5ccccc45)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | ||
CHEMBL477784 | 188563 | 0 | None | - | 1 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 502 | 5 | 0 | 5 | 6.0 | COc1cccc(-n2cc(C(=O)N3CCN(c4cccc5ccccc45)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | ||
70695933 | 80411 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 607 | 7 | 1 | 6 | 5.7 | O=C1C(Cc2c[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc2N1CC(=O)N1CCCC1Cc1ccccn1 | 10.1016/j.bmcl.2012.02.049 | ||
CHEMBL2017823 | 80411 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 607 | 7 | 1 | 6 | 5.7 | O=C1C(Cc2c[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc2N1CC(=O)N1CCCC1Cc1ccccn1 | 10.1016/j.bmcl.2012.02.049 | ||
54583297 | 68695 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 558 | 6 | 1 | 6 | 5.9 | COc1ccc(-c2cnc(C(=O)N3CCN(c4cc5ccccc5cc4C(=O)O)CC3)nc2-c2ccc(C)cc2)cc1 | 10.1016/j.bmcl.2011.03.069 | ||
CHEMBL1774040 | 68695 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 558 | 6 | 1 | 6 | 5.9 | COc1ccc(-c2cnc(C(=O)N3CCN(c4cc5ccccc5cc4C(=O)O)CC3)nc2-c2ccc(C)cc2)cc1 | 10.1016/j.bmcl.2011.03.069 | ||
54582287 | 68643 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 501 | 5 | 0 | 6 | 5.3 | COc1ccc(-c2cnc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccccc2)cc1 | 10.1016/j.bmcl.2011.03.069 | ||
CHEMBL1773892 | 68643 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 501 | 5 | 0 | 6 | 5.3 | COc1ccc(-c2cnc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccccc2)cc1 | 10.1016/j.bmcl.2011.03.069 | ||
24785431 | 196589 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 520 | 6 | 0 | 5 | 6.2 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2ccccc2F)c1 | 10.1016/j.bmcl.2008.06.057 | ||
CHEMBL516355 | 196589 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 520 | 6 | 0 | 5 | 6.2 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2ccccc2F)c1 | 10.1016/j.bmcl.2008.06.057 | ||
24784941 | 196497 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 516 | 6 | 0 | 5 | 6.4 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | ||
CHEMBL515616 | 196497 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 516 | 6 | 0 | 5 | 6.4 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | ||
CHEMBL2370248 | 216593 | 0 | None | -1 | 2 | Guinea pig | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00093a013 | ||||
155540415 | 179718 | 0 | None | -1584 | 2 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 1862 | 71 | 17 | 23 | 3.6 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
CHEMBL4516868 | 179718 | 0 | None | -1584 | 2 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 1862 | 71 | 17 | 23 | 3.6 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
54580267 | 68646 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 535 | 5 | 0 | 6 | 6.0 | COc1ccc(-c2cnc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccccc2Cl)cc1 | 10.1016/j.bmcl.2011.03.069 | ||
CHEMBL1773895 | 68646 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 535 | 5 | 0 | 6 | 6.0 | COc1ccc(-c2cnc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccccc2Cl)cc1 | 10.1016/j.bmcl.2011.03.069 | ||
52943046 | 24910 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 557 | 8 | 0 | 6 | 5.8 | CC(C)N(Cc1ccccc1)C(=O)CN1C(=O)C(Oc2ccccc2)c2nnc(-c3ccccc3)n2-c2ccccc21 | 10.1016/j.bmcl.2010.08.115 | ||
CHEMBL1269262 | 24910 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 557 | 8 | 0 | 6 | 5.8 | CC(C)N(Cc1ccccc1)C(=O)CN1C(=O)C(Oc2ccccc2)c2nnc(-c3ccccc3)n2-c2ccccc21 | 10.1016/j.bmcl.2010.08.115 | ||
51353551 | 24906 | 16 | None | -18 | 3 | Rat | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 605 | 8 | 3 | 5 | 5.0 | CC(C)N(C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(C(=O)O)c2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1016/j.bmcl.2010.08.115 | ||
CHEMBL1269257 | 24906 | 16 | None | -18 | 3 | Rat | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 605 | 8 | 3 | 5 | 5.0 | CC(C)N(C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(C(=O)O)c2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1016/j.bmcl.2010.08.115 | ||
52946666 | 24908 | 0 | None | -2 | 2 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 600 | 9 | 2 | 7 | 5.6 | CC(C)N(Cc1ccccc1)C(=O)CN1C(=O)C(Nc2cccc(C(=O)O)c2)c2nnc(-c3ccccc3)n2-c2ccccc21 | 10.1016/j.bmcl.2010.08.115 | ||
CHEMBL1269260 | 24908 | 0 | None | -2 | 2 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 600 | 9 | 2 | 7 | 5.6 | CC(C)N(Cc1ccccc1)C(=O)CN1C(=O)C(Nc2cccc(C(=O)O)c2)c2nnc(-c3ccccc3)n2-c2ccccc21 | 10.1016/j.bmcl.2010.08.115 | ||
24785176 | 188342 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 500 | 5 | 0 | 4 | 6.5 | CCc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | ||
CHEMBL476747 | 188342 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 500 | 5 | 0 | 4 | 6.5 | CCc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | ||
70683305 | 80422 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 635 | 7 | 1 | 6 | 6.4 | Cc1cccc(CC2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1016/j.bmcl.2012.02.049 | ||
CHEMBL2017834 | 80422 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 635 | 7 | 1 | 6 | 6.4 | Cc1cccc(CC2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1016/j.bmcl.2012.02.049 | ||
46235271 | 80423 | 2 | None | 3 | 3 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 649 | 7 | 1 | 6 | 6.7 | Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1021/acs.jmedchem.5b01110 | ||
CHEMBL2017835 | 80423 | 2 | None | 3 | 3 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 649 | 7 | 1 | 6 | 6.7 | Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1021/acs.jmedchem.5b01110 | ||
24785179 | 188315 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 502 | 6 | 0 | 5 | 6.1 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2ccccc2)c1 | 10.1016/j.bmcl.2008.06.057 | ||
CHEMBL476520 | 188315 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 502 | 6 | 0 | 5 | 6.1 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2ccccc2)c1 | 10.1016/j.bmcl.2008.06.057 | ||
54584255 | 68691 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 515 | 5 | 0 | 6 | 5.6 | COc1ccc(-c2cnc(C(=O)N3CCN(c4ccc5ncccc5c4)CC3)nc2-c2ccc(C)cc2)cc1 | 10.1016/j.bmcl.2011.03.069 | ||
CHEMBL1774036 | 68691 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 515 | 5 | 0 | 6 | 5.6 | COc1ccc(-c2cnc(C(=O)N3CCN(c4ccc5ncccc5c4)CC3)nc2-c2ccc(C)cc2)cc1 | 10.1016/j.bmcl.2011.03.069 | ||
44578251 | 189211 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 486 | 5 | 0 | 5 | 5.5 | COc1cccc(-n2cc(C(=O)N3CCN(c4cccc(Cl)c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | ||
CHEMBL478604 | 189211 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 486 | 5 | 0 | 5 | 5.5 | COc1cccc(-n2cc(C(=O)N3CCN(c4cccc(Cl)c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | ||
44578423 | 196438 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 503 | 5 | 0 | 6 | 5.4 | COc1cccc(-n2cc(C(=O)N3CCN(c4cc5ccccc5cn4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | ||
CHEMBL515161 | 196438 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 503 | 5 | 0 | 6 | 5.4 | COc1cccc(-n2cc(C(=O)N3CCN(c4cc5ccccc5cn4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | ||
155533520 | 178607 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 910 | 26 | 8 | 9 | 2.5 | CCCC[C@H](NC(=O)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
CHEMBL4468598 | 178607 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 910 | 26 | 8 | 9 | 2.5 | CCCC[C@H](NC(=O)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
24784942 | 188122 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 488 | 4 | 1 | 5 | 5.7 | Cc1ccc(-c2nc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)cn2-c2cccc(O)c2)cc1 | 10.1016/j.bmcl.2008.06.057 | ||
CHEMBL476297 | 188122 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 488 | 4 | 1 | 5 | 5.7 | Cc1ccc(-c2nc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)cn2-c2cccc(O)c2)cc1 | 10.1016/j.bmcl.2008.06.057 | ||
46234970 | 80415 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 620 | 7 | 1 | 5 | 6.7 | O=C1C(Cc2c[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc2N1CC(=O)N1CCCCC1Cc1ccccc1 | 10.1016/j.bmcl.2012.02.049 | ||
CHEMBL2017827 | 80415 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 620 | 7 | 1 | 5 | 6.7 | O=C1C(Cc2c[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc2N1CC(=O)N1CCCCC1Cc1ccccc1 | 10.1016/j.bmcl.2012.02.049 | ||
136000594 | 68641 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 517 | 4 | 2 | 7 | 5.0 | Cc1ccc(-c2nc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)ncc2-c2ccc(O)c(O)c2)cc1 | 10.1016/j.bmcl.2011.03.069 | ||
CHEMBL1773890 | 68641 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 517 | 4 | 2 | 7 | 5.0 | Cc1ccc(-c2nc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)ncc2-c2ccc(O)c(O)c2)cc1 | 10.1016/j.bmcl.2011.03.069 | ||
44578399 | 188733 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 492 | 5 | 1 | 6 | 4.7 | COc1cccc(-n2cc(C(=O)N3CCN(c4nc5ccccc5[nH]4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | ||
CHEMBL477996 | 188733 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 492 | 5 | 1 | 6 | 4.7 | COc1cccc(-n2cc(C(=O)N3CCN(c4nc5ccccc5[nH]4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | ||
10509945 | 96159 | 0 | None | 63 | 2 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 896 | 26 | 9 | 9 | 2.1 | CCCC[C@H](NC(=O)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
CHEMBL2369816 | 96159 | 0 | None | 63 | 2 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 896 | 26 | 9 | 9 | 2.1 | CCCC[C@H](NC(=O)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
44578455 | 189234 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 503 | 5 | 0 | 6 | 5.4 | COc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ncccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | ||
CHEMBL478630 | 189234 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 503 | 5 | 0 | 6 | 5.4 | COc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ncccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | ||
24784940 | 189566 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 502 | 5 | 0 | 5 | 6.0 | COc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | ||
CHEMBL479046 | 189566 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 502 | 5 | 0 | 5 | 6.0 | COc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | ||
54581302 | 68696 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 572 | 6 | 0 | 7 | 6.0 | COC(=O)c1cc(N2CCN(C(=O)c3ncc(-c4ccc(OC)cc4)c(-c4ccc(C)cc4)n3)CC2)cc2ccccc12 | 10.1016/j.bmcl.2011.03.069 | ||
CHEMBL1774041 | 68696 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 572 | 6 | 0 | 7 | 6.0 | COC(=O)c1cc(N2CCN(C(=O)c3ncc(-c4ccc(OC)cc4)c(-c4ccc(C)cc4)n3)CC2)cc2ccccc12 | 10.1016/j.bmcl.2011.03.069 | ||
44336539 | 11916 | 0 | None | 1 | 3 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 563 | 7 | 2 | 5 | 4.6 | COc1ccc(N(C)C(=O)CN2C(=O)C(NC(=O)Nc3ccccc3)C(=O)N(c3ccccc3)c3ccccc32)cc1 | 10.1016/j.bmcl.2015.03.051 | ||
CHEMBL105775 | 11916 | 0 | None | 1 | 3 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 563 | 7 | 2 | 5 | 4.6 | COc1ccc(N(C)C(=O)CN2C(=O)C(NC(=O)Nc3ccccc3)C(=O)N(c3ccccc3)c3ccccc32)cc1 | 10.1016/j.bmcl.2015.03.051 | ||
52942901 | 24909 | 0 | None | -1 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 556 | 8 | 1 | 6 | 5.9 | CC(C)N(Cc1ccccc1)C(=O)CN1C(=O)C(Nc2ccccc2)c2nnc(-c3ccccc3)n2-c2ccccc21 | 10.1016/j.bmcl.2010.08.115 | ||
CHEMBL1269261 | 24909 | 0 | None | -1 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 556 | 8 | 1 | 6 | 5.9 | CC(C)N(Cc1ccccc1)C(=O)CN1C(=O)C(Nc2ccccc2)c2nnc(-c3ccccc3)n2-c2ccccc21 | 10.1016/j.bmcl.2010.08.115 | ||
155517868 | 176990 | 0 | None | -457 | 2 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 1893 | 76 | 19 | 24 | 3.2 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
CHEMBL4445353 | 176990 | 0 | None | -457 | 2 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 1893 | 76 | 19 | 24 | 3.2 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | ||
44578529 | 189553 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 530 | 7 | 0 | 5 | 6.8 | CCCOc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | ||
CHEMBL479030 | 189553 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 530 | 7 | 0 | 5 | 6.8 | CCCOc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | ||
443375 | 214385 | 45 | None | 2 | 6 | Human | 10.1 | pIC50 | = | 10.1 | Functional | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00067a001 | ||
CHEMBL9506 | 214385 | 45 | None | 2 | 6 | Human | 10.1 | pIC50 | = | 10.1 | Functional | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00067a001 | ||
44398261 | 131164 | 0 | None | -91 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 577 | 7 | 4 | 6 | 4.2 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(S)N(Cc3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
CHEMBL363916 | 131164 | 0 | None | -91 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 577 | 7 | 4 | 6 | 4.2 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(S)N(Cc3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
11027990 | 74306 | 0 | None | -100 | 2 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 545 | 6 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
CHEMBL189634 | 74306 | 0 | None | -100 | 2 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 545 | 6 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
44398261 | 131164 | 0 | None | -91 | 2 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 577 | 7 | 4 | 6 | 4.2 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(S)N(Cc3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
CHEMBL363916 | 131164 | 0 | None | -91 | 2 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 577 | 7 | 4 | 6 | 4.2 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(S)N(Cc3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
3035433 | 106244 | 15 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 535 | 4 | 3 | 7 | 3.1 | CC(C)C[C@@H]1N[C@H]2N(C1=O)c1ccccc1[C@@]2(O)C[C@@H]1NC(=O)c2ccccc2-n2c1nc1ccccc1c2=O | 10.1021/jm00067a001 | ||
CHEMBL283117 | 106244 | 15 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 535 | 4 | 3 | 7 | 3.1 | CC(C)C[C@@H]1N[C@H]2N(C1=O)c1ccccc1[C@@]2(O)C[C@@H]1NC(=O)c2ccccc2-n2c1nc1ccccc1c2=O | 10.1021/jm00067a001 | ||
44398261 | 131164 | 0 | None | -91 | 2 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 577 | 7 | 4 | 6 | 4.2 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(S)N(Cc3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
CHEMBL363916 | 131164 | 0 | None | -91 | 2 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 577 | 7 | 4 | 6 | 4.2 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(S)N(Cc3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
44398261 | 131164 | 0 | None | -91 | 2 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 577 | 7 | 4 | 6 | 4.2 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(S)N(Cc3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
CHEMBL363916 | 131164 | 0 | None | -91 | 2 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 577 | 7 | 4 | 6 | 4.2 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(S)N(Cc3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
10507071 | 120387 | 0 | None | -524 | 4 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 559 | 7 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
CHEMBL332261 | 120387 | 0 | None | -524 | 4 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 559 | 7 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
10008654 | 134394 | 0 | None | -7 | 2 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 595 | 6 | 3 | 5 | 5.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3cccc4ccccc34)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
CHEMBL366344 | 134394 | 0 | None | -7 | 2 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 595 | 6 | 3 | 5 | 5.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3cccc4ccccc34)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
11027990 | 74306 | 0 | None | -100 | 2 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 545 | 6 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
CHEMBL189634 | 74306 | 0 | None | -100 | 2 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 545 | 6 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
11027990 | 74306 | 0 | None | -100 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 545 | 6 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
CHEMBL189634 | 74306 | 0 | None | -100 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 545 | 6 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
11027990 | 74306 | 0 | None | -100 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 545 | 6 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
CHEMBL189634 | 74306 | 0 | None | -100 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 545 | 6 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
10008654 | 134394 | 0 | None | -7 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 595 | 6 | 3 | 5 | 5.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3cccc4ccccc34)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
CHEMBL366344 | 134394 | 0 | None | -7 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 595 | 6 | 3 | 5 | 5.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3cccc4ccccc34)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
10008654 | 134394 | 0 | None | -7 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 595 | 6 | 3 | 5 | 5.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3cccc4ccccc34)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
CHEMBL366344 | 134394 | 0 | None | -7 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 595 | 6 | 3 | 5 | 5.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3cccc4ccccc34)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
44398261 | 131164 | 0 | None | -91 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 577 | 7 | 4 | 6 | 4.2 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(S)N(Cc3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
CHEMBL363916 | 131164 | 0 | None | -91 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 577 | 7 | 4 | 6 | 4.2 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(S)N(Cc3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
CHEMBL375360 | 218997 | 4 | None | -1 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm061268p | ||||
44398261 | 131164 | 0 | None | -91 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 577 | 7 | 4 | 6 | 4.2 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(S)N(Cc3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
CHEMBL363916 | 131164 | 0 | None | -91 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 577 | 7 | 4 | 6 | 4.2 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(S)N(Cc3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
52949124 | 7663 | 4 | None | 2 | 3 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | ||
9055 | 7663 | 4 | None | 2 | 3 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | ||
CHEMBL1269258 | 7663 | 4 | None | 2 | 3 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | ||
DB12694 | 7663 | 4 | None | 2 | 3 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | ||
10008654 | 134394 | 0 | None | -7 | 2 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 595 | 6 | 3 | 5 | 5.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3cccc4ccccc34)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
CHEMBL366344 | 134394 | 0 | None | -7 | 2 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 595 | 6 | 3 | 5 | 5.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3cccc4ccccc34)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
44398261 | 131164 | 0 | None | -91 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 577 | 7 | 4 | 6 | 4.2 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(S)N(Cc3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
CHEMBL363916 | 131164 | 0 | None | -91 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 577 | 7 | 4 | 6 | 4.2 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(S)N(Cc3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
11027990 | 74306 | 0 | None | -100 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 545 | 6 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
CHEMBL189634 | 74306 | 0 | None | -100 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 545 | 6 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
11027990 | 74306 | 0 | None | -100 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 545 | 6 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
CHEMBL189634 | 74306 | 0 | None | -100 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 545 | 6 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
11027990 | 74306 | 0 | None | -100 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 545 | 6 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
CHEMBL189634 | 74306 | 0 | None | -100 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 545 | 6 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
11027990 | 74306 | 0 | None | -100 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 545 | 6 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
CHEMBL189634 | 74306 | 0 | None | -100 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 545 | 6 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
11027990 | 74306 | 0 | None | -100 | 2 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 545 | 6 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
CHEMBL189634 | 74306 | 0 | None | -100 | 2 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 545 | 6 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
10008654 | 134394 | 0 | None | -7 | 2 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 595 | 6 | 3 | 5 | 5.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3cccc4ccccc34)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
CHEMBL366344 | 134394 | 0 | None | -7 | 2 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 595 | 6 | 3 | 5 | 5.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3cccc4ccccc34)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
44398261 | 131164 | 0 | None | -91 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 577 | 7 | 4 | 6 | 4.2 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(S)N(Cc3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
CHEMBL363916 | 131164 | 0 | None | -91 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 577 | 7 | 4 | 6 | 4.2 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(S)N(Cc3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
44398261 | 131164 | 0 | None | -91 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 577 | 7 | 4 | 6 | 4.2 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(S)N(Cc3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
CHEMBL363916 | 131164 | 0 | None | -91 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 577 | 7 | 4 | 6 | 4.2 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(S)N(Cc3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
11027990 | 74306 | 0 | None | -100 | 2 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 545 | 6 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
CHEMBL189634 | 74306 | 0 | None | -100 | 2 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 545 | 6 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
10008654 | 134394 | 0 | None | -7 | 2 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 595 | 6 | 3 | 5 | 5.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3cccc4ccccc34)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
CHEMBL366344 | 134394 | 0 | None | -7 | 2 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 595 | 6 | 3 | 5 | 5.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3cccc4ccccc34)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
44398261 | 131164 | 0 | None | -91 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 577 | 7 | 4 | 6 | 4.2 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(S)N(Cc3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
CHEMBL363916 | 131164 | 0 | None | -91 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 577 | 7 | 4 | 6 | 4.2 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(S)N(Cc3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
10008654 | 134394 | 0 | None | -7 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 595 | 6 | 3 | 5 | 5.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3cccc4ccccc34)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
CHEMBL366344 | 134394 | 0 | None | -7 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 595 | 6 | 3 | 5 | 5.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3cccc4ccccc34)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
11027990 | 74306 | 0 | None | -100 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 545 | 6 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
CHEMBL189634 | 74306 | 0 | None | -100 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 545 | 6 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
10008654 | 134394 | 0 | None | -7 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 595 | 6 | 3 | 5 | 5.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3cccc4ccccc34)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
CHEMBL366344 | 134394 | 0 | None | -7 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 595 | 6 | 3 | 5 | 5.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3cccc4ccccc34)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
10008654 | 134394 | 0 | None | -7 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 595 | 6 | 3 | 5 | 5.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3cccc4ccccc34)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
CHEMBL366344 | 134394 | 0 | None | -7 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 595 | 6 | 3 | 5 | 5.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3cccc4ccccc34)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
10008654 | 134394 | 0 | None | -7 | 2 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 595 | 6 | 3 | 5 | 5.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3cccc4ccccc34)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
CHEMBL366344 | 134394 | 0 | None | -7 | 2 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 595 | 6 | 3 | 5 | 5.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3cccc4ccccc34)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
44398261 | 131164 | 0 | None | -91 | 2 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 577 | 7 | 4 | 6 | 4.2 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(S)N(Cc3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
CHEMBL363916 | 131164 | 0 | None | -91 | 2 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 577 | 7 | 4 | 6 | 4.2 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(S)N(Cc3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
10008654 | 134394 | 0 | None | -7 | 2 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 595 | 6 | 3 | 5 | 5.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3cccc4ccccc34)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
CHEMBL366344 | 134394 | 0 | None | -7 | 2 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 595 | 6 | 3 | 5 | 5.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3cccc4ccccc34)C(=O)C[C@@H]12 | 10.1021/jm0501127 | ||
44306887 | 108838 | 0 | None | - | 2 | Guinea pig | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 816 | 18 | 9 | 7 | 3.4 | CC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NC(Cc1cccc(NC(=O)Nc2ccccc2C)c1)C(=O)N[C@H](CC(=O)O)C(=O)N[C@@H](Cc1ccc(C)cc1)C(N)=O | 10.1021/jm00001a027 | ||
CHEMBL302027 | 108838 | 0 | None | - | 2 | Guinea pig | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 816 | 18 | 9 | 7 | 3.4 | CC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NC(Cc1cccc(NC(=O)Nc2ccccc2C)c1)C(=O)N[C@H](CC(=O)O)C(=O)N[C@@H](Cc1ccc(C)cc1)C(N)=O | 10.1021/jm00001a027 | ||
44306360 | 164654 | 0 | None | - | 2 | Guinea pig | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 816 | 18 | 9 | 7 | 3.4 | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NC(Cc1ccc(NC(=O)Nc2ccccc2C)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccc(C)cc1)C(N)=O | 10.1021/jm00001a027 | ||
CHEMBL408395 | 164654 | 0 | None | - | 2 | Guinea pig | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 816 | 18 | 9 | 7 | 3.4 | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NC(Cc1ccc(NC(=O)Nc2ccccc2C)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccc(C)cc1)C(N)=O | 10.1021/jm00001a027 | ||
44458112 | 105483 | 0 | None | - | 1 | Guinea pig | 8.2 | pKd | = | 8.2 | Functional | ChEMBL | 374 | 4 | 2 | 3 | 2.7 | O=C(N[C@@H]1C(=O)N(c2ccccc2)C[C@@H]1C(=O)O)c1ccc2ccccc2c1 | 10.1016/S0960-894X(00)80224-3 | ||
CHEMBL277661 | 105483 | 0 | None | - | 1 | Guinea pig | 8.2 | pKd | = | 8.2 | Functional | ChEMBL | 374 | 4 | 2 | 3 | 2.7 | O=C(N[C@@H]1C(=O)N(c2ccccc2)C[C@@H]1C(=O)O)c1ccc2ccccc2c1 | 10.1016/S0960-894X(00)80224-3 | ||
44306888 | 109107 | 0 | None | - | 2 | Guinea pig | 7.2 | pKd | = | 7.2 | Functional | ChEMBL | 816 | 18 | 9 | 7 | 3.4 | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NC(Cc1cccc(NC(=O)Nc2ccccc2C)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccc(C)cc1)C(N)=O | 10.1021/jm00001a027 | ||
CHEMBL303635 | 109107 | 0 | None | - | 2 | Guinea pig | 7.2 | pKd | = | 7.2 | Functional | ChEMBL | 816 | 18 | 9 | 7 | 3.4 | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NC(Cc1cccc(NC(=O)Nc2ccccc2C)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccc(C)cc1)C(N)=O | 10.1021/jm00001a027 | ||
44306868 | 108860 | 0 | None | - | 2 | Guinea pig | 7.1 | pKd | = | 7.1 | Functional | ChEMBL | 836 | 18 | 9 | 7 | 3.7 | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NC(Cc1ccc(NC(=O)Nc2ccccc2Cl)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccc(C)cc1)C(N)=O | 10.1021/jm00001a027 | ||
CHEMBL302150 | 108860 | 0 | None | - | 2 | Guinea pig | 7.1 | pKd | = | 7.1 | Functional | ChEMBL | 836 | 18 | 9 | 7 | 3.7 | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NC(Cc1ccc(NC(=O)Nc2ccccc2Cl)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccc(C)cc1)C(N)=O | 10.1021/jm00001a027 | ||
2360 | 10070 | 0 | None | - | 1 | Rat | 8.4 | pIC50 | = | 8.4 | Functional | Drug Central | 370 | 5 | 3 | 3 | 2.6 | Clc1ccc(cc1)C(=O)NC(C(=O)O)Cc1cc(=O)[nH]c2c1cccc2 | None | ||
5042 | 10070 | 0 | None | - | 1 | Rat | 8.4 | pIC50 | = | 8.4 | Functional | Drug Central | 370 | 5 | 3 | 3 | 2.6 | Clc1ccc(cc1)C(=O)NC(C(=O)O)Cc1cc(=O)[nH]c2c1cccc2 | None | ||
871 | 10070 | 0 | None | - | 1 | Rat | 8.4 | pIC50 | = | 8.4 | Functional | Drug Central | 370 | 5 | 3 | 3 | 2.6 | Clc1ccc(cc1)C(=O)NC(C(=O)O)Cc1cc(=O)[nH]c2c1cccc2 | None | ||
CHEMBL1697771 | 10070 | 0 | None | - | 1 | Rat | 8.4 | pIC50 | = | 8.4 | Functional | Drug Central | 370 | 5 | 3 | 3 | 2.6 | Clc1ccc(cc1)C(=O)NC(C(=O)O)Cc1cc(=O)[nH]c2c1cccc2 | None | ||
DB11656 | 10070 | 0 | None | - | 1 | Rat | 8.4 | pIC50 | = | 8.4 | Functional | Drug Central | 370 | 5 | 3 | 3 | 2.6 | Clc1ccc(cc1)C(=O)NC(C(=O)O)Cc1cc(=O)[nH]c2c1cccc2 | None | ||
1614 | 9128 | 67 | None | -1 | 2 | Rat | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 460 | 14 | 2 | 4 | 4.0 | CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCOC | None | ||
60182 | 9128 | 67 | None | -1 | 2 | Rat | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 460 | 14 | 2 | 4 | 4.0 | CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCOC | None | ||
892 | 9128 | 67 | None | -1 | 2 | Rat | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 460 | 14 | 2 | 4 | 4.0 | CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCOC | None | ||
CHEMBL206025 | 9128 | 67 | None | -1 | 2 | Rat | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 460 | 14 | 2 | 4 | 4.0 | CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCOC | None | ||
65937 | 8185 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 460 | 14 | 2 | 4 | 4.0 | CCCCCN(C(=O)[C@H](NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCOC | None | ||
834 | 8185 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 460 | 14 | 2 | 4 | 4.0 | CCCCCN(C(=O)[C@H](NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCOC | None | ||
889 | 8185 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 460 | 14 | 2 | 4 | 4.0 | CCCCCN(C(=O)[C@H](NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCOC | None | ||
CHEMBL550781 | 8185 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 460 | 14 | 2 | 4 | 4.0 | CCCCCN(C(=O)[C@H](NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCOC | None | ||
DB04856 | 8185 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 460 | 14 | 2 | 4 | 4.0 | CCCCCN(C(=O)[C@H](NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCOC | None | ||
4329839 | 7606 | 0 | None | -158 | 2 | Rat | 5.3 | pIC50 | = | 5.3 | Functional | Guide to Pharmacology | None | None | None | None | 1975695 | ||||
861 | 7606 | 0 | None | -158 | 2 | Rat | 5.3 | pIC50 | = | 5.3 | Functional | Guide to Pharmacology | None | None | None | None | 1975695 | ||||
16168172 | 8552 | 0 | None | -158 | 2 | Rat | 6.1 | pIC50 | = | 6.1 | Functional | Guide to Pharmacology | None | None | None | None | 1975695 | ||||
3559 | 8552 | 0 | None | -158 | 2 | Rat | 6.1 | pIC50 | = | 6.1 | Functional | Guide to Pharmacology | None | None | None | None | 1975695 | ||||
444007 | 9817 | 0 | None | -794 | 2 | Rat | 6.2 | pIC50 | = | 6.2 | Functional | Guide to Pharmacology | None | None | None | None | 1975695 | ||||
870 | 9817 | 0 | None | -794 | 2 | Rat | 6.2 | pIC50 | = | 6.2 | Functional | Guide to Pharmacology | None | None | None | None | 1975695 | ||||
DB00183 | 9817 | 0 | None | -794 | 2 | Rat | 6.2 | pIC50 | = | 6.2 | Functional | Guide to Pharmacology | None | None | None | None | 1975695 | ||||
3960 | 9124 | 23 | None | 53 | 4 | Rat | 7.5 | pIC50 | = | 7.5 | Functional | Guide to Pharmacology | 458 | 14 | 2 | 3 | 5.2 | CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCCC | 1975695 | ||
3960 | 9124 | 23 | None | 53 | 4 | Rat | 7.5 | pIC50 | = | 7.5 | Functional | Guide to Pharmacology | 458 | 14 | 2 | 3 | 5.2 | CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCCC | 2437574 | ||
891 | 9124 | 23 | None | 53 | 4 | Rat | 7.5 | pIC50 | = | 7.5 | Functional | Guide to Pharmacology | 458 | 14 | 2 | 3 | 5.2 | CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCCC | 1975695 | ||
891 | 9124 | 23 | None | 53 | 4 | Rat | 7.5 | pIC50 | = | 7.5 | Functional | Guide to Pharmacology | 458 | 14 | 2 | 3 | 5.2 | CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCCC | 2437574 | ||
CHEMBL24938 | 9124 | 23 | None | 53 | 4 | Rat | 7.5 | pIC50 | = | 7.5 | Functional | Guide to Pharmacology | 458 | 14 | 2 | 3 | 5.2 | CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCCC | 1975695 | ||
CHEMBL24938 | 9124 | 23 | None | 53 | 4 | Rat | 7.5 | pIC50 | = | 7.5 | Functional | Guide to Pharmacology | 458 | 14 | 2 | 3 | 5.2 | CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCCC | 2437574 | ||
52949124 | 7663 | 4 | None | 2 | 3 | Human | 7.5 | pIC50 | = | 7.5 | Functional | Guide to Pharmacology | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 20851601 | ||
9055 | 7663 | 4 | None | 2 | 3 | Human | 7.5 | pIC50 | = | 7.5 | Functional | Guide to Pharmacology | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 20851601 | ||
CHEMBL1269258 | 7663 | 4 | None | 2 | 3 | Human | 7.5 | pIC50 | = | 7.5 | Functional | Guide to Pharmacology | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 20851601 | ||
DB12694 | 7663 | 4 | None | 2 | 3 | Human | 7.5 | pIC50 | = | 7.5 | Functional | Guide to Pharmacology | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 20851601 | ||
5311148 | 8677 | 7 | None | 41 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | Guide to Pharmacology | 587 | 8 | 1 | 5 | 5.9 | COc1ccc(cc1)N(C(=O)CN1C(=O)C(Cc2[nH]nc3c2cccc3)C(=O)N(c2c1cccc2)c1ccccc1)C(C)C | 9276016 | ||
865 | 8677 | 7 | None | 41 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | Guide to Pharmacology | 587 | 8 | 1 | 5 | 5.9 | COc1ccc(cc1)N(C(=O)CN1C(=O)C(Cc2[nH]nc3c2cccc3)C(=O)N(c2c1cccc2)c1ccccc1)C(C)C | 9276016 | ||
CHEMBL293226 | 8677 | 7 | None | 41 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | Guide to Pharmacology | 587 | 8 | 1 | 5 | 5.9 | COc1ccc(cc1)N(C(=O)CN1C(=O)C(Cc2[nH]nc3c2cccc3)C(=O)N(c2c1cccc2)c1ccccc1)C(C)C | 9276016 | ||
3888 | 8903 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Guide to Pharmacology | None | None | None | None | 7654246 | ||||
5311196 | 8903 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Guide to Pharmacology | None | None | None | None | 7654246 | ||||
122077 | 9102 | 51 | None | -8 | 2 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Guide to Pharmacology | 411 | 5 | 2 | 5 | 4.8 | OC(=O)Cn1c(cc2c1cccc2)C(=O)Nc1scc(n1)c1ccccc1Cl | 10988332 | ||
890 | 9102 | 51 | None | -8 | 2 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Guide to Pharmacology | 411 | 5 | 2 | 5 | 4.8 | OC(=O)Cn1c(cc2c1cccc2)C(=O)Nc1scc(n1)c1ccccc1Cl | 10988332 | ||
CHEMBL249973 | 9102 | 51 | None | -8 | 2 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Guide to Pharmacology | 411 | 5 | 2 | 5 | 4.8 | OC(=O)Cn1c(cc2c1cccc2)C(=O)Nc1scc(n1)c1ccccc1Cl | 10988332 | ||
DB04867 | 9102 | 51 | None | -8 | 2 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Guide to Pharmacology | 411 | 5 | 2 | 5 | 4.8 | OC(=O)Cn1c(cc2c1cccc2)C(=O)Nc1scc(n1)c1ccccc1Cl | 10988332 | ||
121964 | 6995 | 34 | None | 4265 | 2 | Rat | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | None | None | None | None | 1636779 | ||||
858 | 6995 | 34 | None | 4265 | 2 | Rat | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | None | None | None | None | 1636779 | ||||
CHEMBL323521 | 6995 | 34 | None | 4265 | 2 | Rat | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | None | None | None | None | 1636779 | ||||
904 | 9800 | 10 | None | 3 | 3 | Rat | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 8605955 | ||
9915756 | 9800 | 10 | None | 3 | 3 | Rat | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 8605955 | ||
CHEMBL2111204 | 9800 | 10 | None | 3 | 3 | Rat | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 8605955 | ||
CHEMBL356898 | 9800 | 10 | None | 3 | 3 | Rat | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 8605955 | ||
862 | 7607 | 0 | None | -1 | 2 | Mouse | 9.2 | pIC50 | = | 9.2 | Functional | Guide to Pharmacology | None | None | None | None | 12370550 | ||||
127948 | 10491 | 0 | None | 79432 | 2 | Rat | 9.6 | pIC50 | = | 9.6 | Functional | Guide to Pharmacology | 502 | 7 | 2 | 4 | 4.5 | COc1ccc2c(c1)N(c1ccccc1F)C(=O)[C@@]2(CCC(=O)O)NC(=O)C1CCc2c(C1)cccc2 | 8813597 | ||
884 | 10491 | 0 | None | 79432 | 2 | Rat | 9.6 | pIC50 | = | 9.6 | Functional | Guide to Pharmacology | 502 | 7 | 2 | 4 | 4.5 | COc1ccc2c(c1)N(c1ccccc1F)C(=O)[C@@]2(CCC(=O)O)NC(=O)C1CCc2c(C1)cccc2 | 8813597 | ||
3476 | 8182 | 9 | None | 870 | 2 | Rat | 9.7 | pIC50 | = | 9.7 | Functional | Guide to Pharmacology | 408 | 3 | 2 | 3 | 3.7 | O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 | 1975695 | ||
59751 | 8182 | 9 | None | 870 | 2 | Rat | 9.7 | pIC50 | = | 9.7 | Functional | Guide to Pharmacology | 408 | 3 | 2 | 3 | 3.7 | O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 | 1975695 | ||
878 | 8182 | 9 | None | 870 | 2 | Rat | 9.7 | pIC50 | = | 9.7 | Functional | Guide to Pharmacology | 408 | 3 | 2 | 3 | 3.7 | O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 | 1975695 | ||
CHEMBL39263 | 8182 | 9 | None | 870 | 2 | Rat | 9.7 | pIC50 | = | 9.7 | Functional | Guide to Pharmacology | 408 | 3 | 2 | 3 | 3.7 | O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 | 1975695 | ||
4627 | 7609 | 50 | None | -2 | 6 | Rat | 9.9 | pIC50 | = | 9.9 | Functional | Guide to Pharmacology | None | None | None | None | 1975695 | ||||
864 | 7609 | 50 | None | -2 | 6 | Rat | 9.9 | pIC50 | = | 9.9 | Functional | Guide to Pharmacology | None | None | None | None | 1975695 | ||||
9833444 | 7609 | 50 | None | -2 | 6 | Rat | 9.9 | pIC50 | = | 9.9 | Functional | Guide to Pharmacology | None | None | None | None | 1975695 | ||||
CHEMBL1121 | 7609 | 50 | None | -2 | 6 | Rat | 9.9 | pIC50 | = | 9.9 | Functional | Guide to Pharmacology | None | None | None | None | 1975695 | ||||
DB09142 | 7609 | 50 | None | -2 | 6 | Rat | 9.9 | pIC50 | = | 9.9 | Functional | Guide to Pharmacology | None | None | None | None | 1975695 | ||||
2281 | 9949 | 82 | None | -2454 | 2 | Rat | 2.2 | pIC50 | None | 2.2 | Functional | Guide to Pharmacology | 334 | 10 | 2 | 3 | 2.3 | CCCN(C(=O)C(NC(=O)c1ccccc1)CCC(=O)O)CCC | 3440035 | ||
4922 | 9949 | 82 | None | -2454 | 2 | Rat | 2.2 | pIC50 | None | 2.2 | Functional | Guide to Pharmacology | 334 | 10 | 2 | 3 | 2.3 | CCCN(C(=O)C(NC(=O)c1ccccc1)CCC(=O)O)CCC | 3440035 | ||
893 | 9949 | 82 | None | -2454 | 2 | Rat | 2.2 | pIC50 | None | 2.2 | Functional | Guide to Pharmacology | 334 | 10 | 2 | 3 | 2.3 | CCCN(C(=O)C(NC(=O)c1ccccc1)CCC(=O)O)CCC | 3440035 | ||
CHEMBL316561 | 9949 | 82 | None | -2454 | 2 | Rat | 2.2 | pIC50 | None | 2.2 | Functional | Guide to Pharmacology | 334 | 10 | 2 | 3 | 2.3 | CCCN(C(=O)C(NC(=O)c1ccccc1)CCC(=O)O)CCC | 3440035 | ||
DB13431 | 9949 | 82 | None | -2454 | 2 | Rat | 2.2 | pIC50 | None | 2.2 | Functional | Guide to Pharmacology | 334 | 10 | 2 | 3 | 2.3 | CCCN(C(=O)C(NC(=O)c1ccccc1)CCC(=O)O)CCC | 3440035 | ||
2360 | 10070 | 0 | None | - | 1 | Rat | 4.4 | pIC50 | None | 4.4 | Functional | Guide to Pharmacology | 370 | 5 | 3 | 3 | 2.6 | Clc1ccc(cc1)C(=O)NC(C(=O)O)Cc1cc(=O)[nH]c2c1cccc2 | 15556137 | ||
5042 | 10070 | 0 | None | - | 1 | Rat | 4.4 | pIC50 | None | 4.4 | Functional | Guide to Pharmacology | 370 | 5 | 3 | 3 | 2.6 | Clc1ccc(cc1)C(=O)NC(C(=O)O)Cc1cc(=O)[nH]c2c1cccc2 | 15556137 | ||
871 | 10070 | 0 | None | - | 1 | Rat | 4.4 | pIC50 | None | 4.4 | Functional | Guide to Pharmacology | 370 | 5 | 3 | 3 | 2.6 | Clc1ccc(cc1)C(=O)NC(C(=O)O)Cc1cc(=O)[nH]c2c1cccc2 | 15556137 | ||
CHEMBL1697771 | 10070 | 0 | None | - | 1 | Rat | 4.4 | pIC50 | None | 4.4 | Functional | Guide to Pharmacology | 370 | 5 | 3 | 3 | 2.6 | Clc1ccc(cc1)C(=O)NC(C(=O)O)Cc1cc(=O)[nH]c2c1cccc2 | 15556137 | ||
DB11656 | 10070 | 0 | None | - | 1 | Rat | 4.4 | pIC50 | None | 4.4 | Functional | Guide to Pharmacology | 370 | 5 | 3 | 3 | 2.6 | Clc1ccc(cc1)C(=O)NC(C(=O)O)Cc1cc(=O)[nH]c2c1cccc2 | 15556137 | ||
108187 | 7713 | 37 | None | -794 | 5 | Rat | 5.6 | pIC50 | None | 5.6 | Functional | Guide to Pharmacology | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 1975695 | ||
873 | 7713 | 37 | None | -794 | 5 | Rat | 5.6 | pIC50 | None | 5.6 | Functional | Guide to Pharmacology | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 1975695 | ||
CHEMBL2062154 | 7713 | 37 | None | -794 | 5 | Rat | 5.6 | pIC50 | None | 5.6 | Functional | Guide to Pharmacology | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 1975695 | ||
CHEMBL287735 | 7713 | 37 | None | -794 | 5 | Rat | 5.6 | pIC50 | None | 5.6 | Functional | Guide to Pharmacology | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 1975695 | ||
122119 | 9797 | 0 | None | -1000 | 2 | Rat | 5.9 | pIC50 | None | 5.9 | Functional | Guide to Pharmacology | 618 | 12 | 5 | 6 | 5.1 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](CC1CNc2c1cccc2)(NC(=O)OC1C[C@H]2C([C@]1(C)CC2)(C)C)C)CCC(=O)O | 1975695 | ||
882 | 9797 | 0 | None | -1000 | 2 | Rat | 5.9 | pIC50 | None | 5.9 | Functional | Guide to Pharmacology | 618 | 12 | 5 | 6 | 5.1 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](CC1CNc2c1cccc2)(NC(=O)OC1C[C@H]2C([C@]1(C)CC2)(C)C)C)CCC(=O)O | 1975695 | ||
880 | 9019 | 5 | None | -7413 | 2 | Rat | 6.4 | pIC50 | None | 6.4 | Functional | Guide to Pharmacology | 487 | 5 | 3 | 7 | 3.5 | O=C(N[C@@H]1N=C(C2CCCCC2)c2c(N(C1=O)C)cccc2)Nc1cccc(c1)N(c1n[nH]nn1)C | 8632408 | ||
9935175 | 9019 | 5 | None | -7413 | 2 | Rat | 6.4 | pIC50 | None | 6.4 | Functional | Guide to Pharmacology | 487 | 5 | 3 | 7 | 3.5 | O=C(N[C@@H]1N=C(C2CCCCC2)c2c(N(C1=O)C)cccc2)Nc1cccc(c1)N(c1n[nH]nn1)C | 8632408 | ||
CHEMBL2093059 | 9019 | 5 | None | -7413 | 2 | Rat | 6.4 | pIC50 | None | 6.4 | Functional | Guide to Pharmacology | 487 | 5 | 3 | 7 | 3.5 | O=C(N[C@@H]1N=C(C2CCCCC2)c2c(N(C1=O)C)cccc2)Nc1cccc(c1)N(c1n[nH]nn1)C | 8632408 | ||
1614 | 9128 | 67 | None | -1 | 2 | Rat | 6.5 | pIC50 | None | 6.5 | Functional | Guide to Pharmacology | 460 | 14 | 2 | 4 | 4.0 | CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCOC | 3663268 | ||
60182 | 9128 | 67 | None | -1 | 2 | Rat | 6.5 | pIC50 | None | 6.5 | Functional | Guide to Pharmacology | 460 | 14 | 2 | 4 | 4.0 | CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCOC | 3663268 | ||
892 | 9128 | 67 | None | -1 | 2 | Rat | 6.5 | pIC50 | None | 6.5 | Functional | Guide to Pharmacology | 460 | 14 | 2 | 4 | 4.0 | CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCOC | 3663268 | ||
CHEMBL206025 | 9128 | 67 | None | -1 | 2 | Rat | 6.5 | pIC50 | None | 6.5 | Functional | Guide to Pharmacology | 460 | 14 | 2 | 4 | 4.0 | CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCOC | 3663268 | ||
104929 | 9000 | 9 | None | -12 | 3 | Rat | 6.6 | pIC50 | None | 6.6 | Functional | Guide to Pharmacology | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 | 1975695 | ||
3477 | 9000 | 9 | None | -12 | 3 | Rat | 6.6 | pIC50 | None | 6.6 | Functional | Guide to Pharmacology | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 | 1975695 | ||
879 | 9000 | 9 | None | -12 | 3 | Rat | 6.6 | pIC50 | None | 6.6 | Functional | Guide to Pharmacology | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 | 1975695 | ||
CHEMBL289498 | 9000 | 9 | None | -12 | 3 | Rat | 6.6 | pIC50 | None | 6.6 | Functional | Guide to Pharmacology | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 | 1975695 | ||
10742947 | 10771 | 0 | None | - | 1 | Rat | 6.7 | pIC50 | None | 6.7 | Functional | Guide to Pharmacology | 469 | 8 | 6 | 4 | 3.7 | OC(=O)CC(c1ccccc1)NC(=O)c1cccc(c1)NC(=O)c1cc2c([nH]1)ccc(c2)C(=N)N | 12538004 | ||
886 | 10771 | 0 | None | - | 1 | Rat | 6.7 | pIC50 | None | 6.7 | Functional | Guide to Pharmacology | 469 | 8 | 6 | 4 | 3.7 | OC(=O)CC(c1ccccc1)NC(=O)c1cccc(c1)NC(=O)c1cc2c([nH]1)ccc(c2)C(=N)N | 12538004 | ||
CHEMBL137814 | 10771 | 0 | None | - | 1 | Rat | 6.7 | pIC50 | None | 6.7 | Functional | Guide to Pharmacology | 469 | 8 | 6 | 4 | 3.7 | OC(=O)CC(c1ccccc1)NC(=O)c1cccc(c1)NC(=O)c1cc2c([nH]1)ccc(c2)C(=N)N | 12538004 | ||
887 | 10882 | 33 | None | -2511 | 3 | Rat | 6.9 | pIC50 | None | 6.9 | Functional | Guide to Pharmacology | 498 | 6 | 3 | 6 | 4.1 | CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 | 9022799 | ||
9870520 | 10882 | 33 | None | -2511 | 3 | Rat | 6.9 | pIC50 | None | 6.9 | Functional | Guide to Pharmacology | 498 | 6 | 3 | 6 | 4.1 | CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 | 9022799 | ||
CHEMBL324547 | 10882 | 33 | None | -2511 | 3 | Rat | 6.9 | pIC50 | None | 6.9 | Functional | Guide to Pharmacology | 498 | 6 | 3 | 6 | 4.1 | CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 | 9022799 | ||
DB12355 | 10882 | 33 | None | -2511 | 3 | Rat | 6.9 | pIC50 | None | 6.9 | Functional | Guide to Pharmacology | 498 | 6 | 3 | 6 | 4.1 | CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 | 9022799 | ||
4627 | 7609 | 50 | None | -2 | 6 | Rat | 7.2 | pIC50 | None | 7.2 | Functional | Guide to Pharmacology | None | None | None | None | 1975695 | ||||
864 | 7609 | 50 | None | -2 | 6 | Rat | 7.2 | pIC50 | None | 7.2 | Functional | Guide to Pharmacology | None | None | None | None | 1975695 | ||||
9833444 | 7609 | 50 | None | -2 | 6 | Rat | 7.2 | pIC50 | None | 7.2 | Functional | Guide to Pharmacology | None | None | None | None | 1975695 | ||||
CHEMBL1121 | 7609 | 50 | None | -2 | 6 | Rat | 7.2 | pIC50 | None | 7.2 | Functional | Guide to Pharmacology | None | None | None | None | 1975695 | ||||
DB09142 | 7609 | 50 | None | -2 | 6 | Rat | 7.2 | pIC50 | None | 7.2 | Functional | Guide to Pharmacology | None | None | None | None | 1975695 | ||||
10348659 | 8585 | 0 | None | 3 | 2 | Human | 7.2 | pIC50 | None | 7.2 | Functional | Guide to Pharmacology | 604 | 8 | 2 | 5 | 5.4 | O=C(NC1C(=O)N(c2ccccc2)c2c(N(C1=O)CC(=O)N(c1ccc(cc1)N(C)C)C(C)C)cccc2)Nc1ccccc1 | 8558528 | ||
866 | 8585 | 0 | None | 3 | 2 | Human | 7.2 | pIC50 | None | 7.2 | Functional | Guide to Pharmacology | 604 | 8 | 2 | 5 | 5.4 | O=C(NC1C(=O)N(c2ccccc2)c2c(N(C1=O)CC(=O)N(c1ccc(cc1)N(C)C)C(C)C)cccc2)Nc1ccccc1 | 8558528 | ||
CHEMBL1184355 | 8585 | 0 | None | 3 | 2 | Human | 7.2 | pIC50 | None | 7.2 | Functional | Guide to Pharmacology | 604 | 8 | 2 | 5 | 5.4 | O=C(NC1C(=O)N(c2ccccc2)c2c(N(C1=O)CC(=O)N(c1ccc(cc1)N(C)C)C(C)C)cccc2)Nc1ccccc1 | 8558528 | ||
19023535 | 10313 | 0 | None | - | 1 | Rat | 7.8 | pIC50 | None | 7.8 | Functional | Guide to Pharmacology | 363 | 4 | 3 | 3 | 2.0 | OC(=O)C1CN(C(=O)C1NC(=O)c1c[nH]c2c1cccc2)c1ccccc1 | None | ||
883 | 10313 | 0 | None | - | 1 | Rat | 7.8 | pIC50 | None | 7.8 | Functional | Guide to Pharmacology | 363 | 4 | 3 | 3 | 2.0 | OC(=O)C1CN(C(=O)C1NC(=O)c1c[nH]c2c1cccc2)c1ccccc1 | None | ||
11757476 | 8845 | 1 | None | - | 1 | Rat | 9.0 | pIC50 | None | 9 | Functional | Guide to Pharmacology | 558 | 7 | 4 | 4 | 3.7 | O=C(NC(C)(C)C)N[C@H](C(=O)N[C@@H]1CCCN2[C@H]1CC(=O)N(C2=O)Cc1ccccc1)Cc1c[nH]c2c1cccc2 | 15331911 | ||
876 | 8845 | 1 | None | - | 1 | Rat | 9.0 | pIC50 | None | 9 | Functional | Guide to Pharmacology | 558 | 7 | 4 | 4 | 3.7 | O=C(NC(C)(C)C)N[C@H](C(=O)N[C@@H]1CCCN2[C@H]1CC(=O)N(C2=O)Cc1ccccc1)Cc1c[nH]c2c1cccc2 | 15331911 | ||
CHEMBL2112828 | 8845 | 1 | None | - | 1 | Rat | 9.0 | pIC50 | None | 9 | Functional | Guide to Pharmacology | 558 | 7 | 4 | 4 | 3.7 | O=C(NC(C)(C)C)N[C@H](C(=O)N[C@@H]1CCCN2[C@H]1CC(=O)N(C2=O)Cc1ccccc1)Cc1c[nH]c2c1cccc2 | 15331911 | ||
868 | 10439 | 0 | None | - | 1 | Human | 9.3 | pIC50 | None | 9.3 | Functional | Guide to Pharmacology | 609 | 10 | 2 | 7 | 7.9 | COc1cc(Cl)c(cc1c1nc(sc1CCC1CCCCC1)NC(=O)c1cc2c(n1CC(=O)O)c(C)cc(c2)C)OC | 10215648 | ||
9852833 | 10439 | 0 | None | - | 1 | Human | 9.3 | pIC50 | None | 9.3 | Functional | Guide to Pharmacology | 609 | 10 | 2 | 7 | 7.9 | COc1cc(Cl)c(cc1c1nc(sc1CCC1CCCCC1)NC(=O)c1cc2c(n1CC(=O)O)c(C)cc(c2)C)OC | 10215648 | ||
CHEMBL3302616 | 10439 | 0 | None | - | 1 | Human | 9.3 | pIC50 | None | 9.3 | Functional | Guide to Pharmacology | 609 | 10 | 2 | 7 | 7.9 | COc1cc(Cl)c(cc1c1nc(sc1CCC1CCCCC1)NC(=O)c1cc2c(n1CC(=O)O)c(C)cc(c2)C)OC | 10215648 | ||
132916 | 9935 | 16 | None | 602 | 2 | Rat | 9.4 | pIC50 | None | 9.4 | Functional | Guide to Pharmacology | 438 | 3 | 2 | 3 | 3.8 | O=C(c1cc2c([nH]1)cccc2)N[C@H]1N=C(c2ccccc2F)c2c3N(C1=O)CCc3ccc2 | 7509389 | ||
874 | 9935 | 16 | None | 602 | 2 | Rat | 9.4 | pIC50 | None | 9.4 | Functional | Guide to Pharmacology | 438 | 3 | 2 | 3 | 3.8 | O=C(c1cc2c([nH]1)cccc2)N[C@H]1N=C(c2ccccc2F)c2c3N(C1=O)CCc3ccc2 | 7509389 | ||
CHEMBL300072 | 9935 | 16 | None | 602 | 2 | Rat | 9.4 | pIC50 | None | 9.4 | Functional | Guide to Pharmacology | 438 | 3 | 2 | 3 | 3.8 | O=C(c1cc2c([nH]1)cccc2)N[C@H]1N=C(c2ccccc2F)c2c3N(C1=O)CCc3ccc2 | 7509389 | ||
122077 | 9102 | 51 | None | 8 | 2 | Rat | 9.7 | pIC50 | None | 9.7 | Functional | Guide to Pharmacology | 411 | 5 | 2 | 5 | 4.8 | OC(=O)Cn1c(cc2c1cccc2)C(=O)Nc1scc(n1)c1ccccc1Cl | 7681406 | ||
890 | 9102 | 51 | None | 8 | 2 | Rat | 9.7 | pIC50 | None | 9.7 | Functional | Guide to Pharmacology | 411 | 5 | 2 | 5 | 4.8 | OC(=O)Cn1c(cc2c1cccc2)C(=O)Nc1scc(n1)c1ccccc1Cl | 7681406 | ||
CHEMBL249973 | 9102 | 51 | None | 8 | 2 | Rat | 9.7 | pIC50 | None | 9.7 | Functional | Guide to Pharmacology | 411 | 5 | 2 | 5 | 4.8 | OC(=O)Cn1c(cc2c1cccc2)C(=O)Nc1scc(n1)c1ccccc1Cl | 7681406 | ||
DB04867 | 9102 | 51 | None | 8 | 2 | Rat | 9.7 | pIC50 | None | 9.7 | Functional | Guide to Pharmacology | 411 | 5 | 2 | 5 | 4.8 | OC(=O)Cn1c(cc2c1cccc2)C(=O)Nc1scc(n1)c1ccccc1Cl | 7681406 |
Ligands (move mouse cursor over ligand name to see structure) | Receptor | Assay information | Chemical information | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Similar- ity |
Common name |
GPCRdb ID |
#Vendors |
Reference ligand |
Fold selectivity |
# Tested GPCRs |
Species |
p-value (-log) |
Activity Type |
Activity Relation |
Activity Value |
Assay Type |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
45138674 | 23418 | 50 | None | - | 0 | Human | 5.0 | pAC50 | = | 5 | Binding | ChEMBL | 572 | 6 | 1 | 7 | 5.7 | COc1cccc(N2CCN(C3=Nc4c(F)cccc4[C@H](CC(=O)O)N3c3cc(C(F)(F)F)ccc3OC)CC2)c1 | 10.1038/s41467-023-40064-9 | |||
CHEMBL1241951 | 23418 | 50 | None | - | 0 | Human | 5.0 | pAC50 | = | 5 | Binding | ChEMBL | 572 | 6 | 1 | 7 | 5.7 | COc1cccc(N2CCN(C3=Nc4c(F)cccc4[C@H](CC(=O)O)N3c3cc(C(F)(F)F)ccc3OC)CC2)c1 | 10.1038/s41467-023-40064-9 | |||
25181577 | 84994 | 56 | None | - | 0 | Human | 5.0 | pAC50 | = | 5 | Binding | ChEMBL | 574 | 9 | 2 | 9 | 5.0 | CCOC(=O)[C@@H](N)Cc1ccc(-c2cc(O[C@H](c3ccc(Cl)cc3-n3ccc(C)n3)C(F)(F)F)nc(N)n2)cc1 | 10.1038/s41467-023-40064-9 | |||
CHEMBL2105695 | 84994 | 56 | None | - | 0 | Human | 5.0 | pAC50 | = | 5 | Binding | ChEMBL | 574 | 9 | 2 | 9 | 5.0 | CCOC(=O)[C@@H](N)Cc1ccc(-c2cc(O[C@H](c3ccc(Cl)cc3-n3ccc(C)n3)C(F)(F)F)nc(N)n2)cc1 | 10.1038/s41467-023-40064-9 | |||
3062316 | 40349 | 121 | None | - | 0 | Human | 5.0 | pAC50 | = | 5.0 | Binding | ChEMBL | 487 | 7 | 3 | 9 | 3.3 | Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1 | 10.1038/s41467-023-40064-9 | |||
CHEMBL1421 | 40349 | 121 | None | - | 0 | Human | 5.0 | pAC50 | = | 5.0 | Binding | ChEMBL | 487 | 7 | 3 | 9 | 3.3 | Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1 | 10.1038/s41467-023-40064-9 | |||
10184653 | 17769 | 107 | None | - | 0 | Human | 5.0 | pAC50 | = | 5.0 | Binding | ChEMBL | 485 | 8 | 2 | 7 | 4.4 | CN(C)C/C=C/C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1 | 10.1038/s41467-023-40064-9 | |||
CHEMBL1173655 | 17769 | 107 | None | - | 0 | Human | 5.0 | pAC50 | = | 5.0 | Binding | ChEMBL | 485 | 8 | 2 | 7 | 4.4 | CN(C)C/C=C/C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1 | 10.1038/s41467-023-40064-9 | |||
25025298 | 84926 | 39 | None | - | 0 | Human | 5.0 | pAC50 | = | 5.0 | Binding | ChEMBL | 546 | 8 | 3 | 8 | 4.5 | Cc1ccn(-c2cc(Cl)ccc2[C@@H](Oc2cc(-c3ccc(C[C@H](N)C(=O)O)cc3)nc(N)n2)C(F)(F)F)n1 | 10.1038/s41467-023-40064-9 | |||
CHEMBL2103855 | 84926 | 39 | None | - | 0 | Human | 5.0 | pAC50 | = | 5.0 | Binding | ChEMBL | 546 | 8 | 3 | 8 | 4.5 | Cc1ccn(-c2cc(Cl)ccc2[C@@H](Oc2cc(-c3ccc(C[C@H](N)C(=O)O)cc3)nc(N)n2)C(F)(F)F)n1 | 10.1038/s41467-023-40064-9 | |||
213046 | 9164 | 59 | None | - | 9 | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 492 | 5 | 0 | 6 | 4.3 | O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 | 10.1038/s41467-023-40064-9 | |||
4168 | 9164 | 59 | None | - | 9 | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 492 | 5 | 0 | 6 | 4.3 | O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 | 10.1038/s41467-023-40064-9 | |||
7461 | 9164 | 59 | None | - | 9 | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 492 | 5 | 0 | 6 | 4.3 | O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 | 10.1038/s41467-023-40064-9 | |||
CHEMBL1237021 | 9164 | 59 | None | - | 9 | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 492 | 5 | 0 | 6 | 4.3 | O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 | 10.1038/s41467-023-40064-9 | |||
DB08815 | 9164 | 59 | None | - | 9 | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 492 | 5 | 0 | 6 | 4.3 | O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 | 10.1038/s41467-023-40064-9 | |||
392622 | 63086 | 95 | None | - | 4 | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 720 | 17 | 4 | 9 | 5.9 | CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1 | 10.1038/s41467-023-40064-9 | |||
CHEMBL163 | 63086 | 95 | None | - | 4 | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 720 | 17 | 4 | 9 | 5.9 | CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1 | 10.1038/s41467-023-40064-9 | |||
6436173 | 61890 | 45 | None | - | 0 | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 785 | 2 | 5 | 13 | 6.2 | CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c5c(nc6cc(C)ccn65)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C | 10.1038/s41467-023-40064-9 | |||
CHEMBL1617 | 61890 | 45 | None | - | 0 | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 785 | 2 | 5 | 13 | 6.2 | CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c5c(nc6cc(C)ccn65)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C | 10.1038/s41467-023-40064-9 | |||
1890 | 9535 | 49 | None | - | 16 | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 469 | 10 | 0 | 7 | 3.6 | CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl | 10.1038/s41467-023-40064-9 | |||
4449 | 9535 | 49 | None | - | 16 | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 469 | 10 | 0 | 7 | 3.6 | CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl | 10.1038/s41467-023-40064-9 | |||
7247 | 9535 | 49 | None | - | 16 | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 469 | 10 | 0 | 7 | 3.6 | CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl | 10.1038/s41467-023-40064-9 | |||
CHEMBL623 | 9535 | 49 | None | - | 16 | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 469 | 10 | 0 | 7 | 3.6 | CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl | 10.1038/s41467-023-40064-9 | |||
DB01149 | 9535 | 49 | None | - | 16 | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 469 | 10 | 0 | 7 | 3.6 | CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl | 10.1038/s41467-023-40064-9 | |||
10831 | 123741 | 25 | None | - | 0 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 397 | 7 | 2 | 5 | 4.3 | O=C(Nc1ccccc1)OCC(CN1CCCCC1)OC(=O)Nc1ccccc1 | 10.1038/s41467-023-40064-9 | |||
CHEMBL338667 | 123741 | 25 | None | - | 0 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 397 | 7 | 2 | 5 | 4.3 | O=C(Nc1ccccc1)OCC(CN1CCCCC1)OC(=O)Nc1ccccc1 | 10.1038/s41467-023-40064-9 | |||
2713 | 212050 | 82 | None | - | 0 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 504 | 9 | 10 | 4 | 4.2 | N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 | 10.1038/s41467-023-40064-9 | |||
5353524 | 212050 | 82 | None | - | 0 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 504 | 9 | 10 | 4 | 4.2 | N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 | 10.1038/s41467-023-40064-9 | |||
5360566 | 212050 | 82 | None | - | 0 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 504 | 9 | 10 | 4 | 4.2 | N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 | 10.1038/s41467-023-40064-9 | |||
88536661 | 212050 | 82 | None | - | 0 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 504 | 9 | 10 | 4 | 4.2 | N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 | 10.1038/s41467-023-40064-9 | |||
9552079 | 212050 | 82 | None | - | 0 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 504 | 9 | 10 | 4 | 4.2 | N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 | 10.1038/s41467-023-40064-9 | |||
CHEMBL1330113 | 212050 | 82 | None | - | 0 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 504 | 9 | 10 | 4 | 4.2 | N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 | 10.1038/s41467-023-40064-9 | |||
CHEMBL790 | 212050 | 82 | None | - | 0 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 504 | 9 | 10 | 4 | 4.2 | N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 | 10.1038/s41467-023-40064-9 | |||
5353627 | 91316 | 8 | None | - | 0 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 411 | 8 | 3 | 4 | 4.6 | CC(C)n1c(/C=C/C(O)CC(O)CC(=O)O)c(-c2ccc(F)cc2)c2ccccc21 | 10.1038/s41467-023-40064-9 | |||
CHEMBL2220442 | 91316 | 8 | None | - | 0 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 411 | 8 | 3 | 4 | 4.6 | CC(C)n1c(/C=C/C(O)CC(O)CC(=O)O)c(-c2ccc(F)cc2)c2ccccc21 | 10.1038/s41467-023-40064-9 | |||
104850 | 10103 | 96 | None | - | 6 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 462 | 4 | 1 | 4 | 5.9 | Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 | 10.1038/s41467-023-40064-9 | |||
4150 | 10103 | 96 | None | - | 6 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 462 | 4 | 1 | 4 | 5.9 | Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 | 10.1038/s41467-023-40064-9 | |||
743 | 10103 | 96 | None | - | 6 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 462 | 4 | 1 | 4 | 5.9 | Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 | 10.1038/s41467-023-40064-9 | |||
CHEMBL111 | 10103 | 96 | None | - | 6 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 462 | 4 | 1 | 4 | 5.9 | Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 | 10.1038/s41467-023-40064-9 | |||
DB06155 | 10103 | 96 | None | - | 6 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 462 | 4 | 1 | 4 | 5.9 | Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 | 10.1038/s41467-023-40064-9 | |||
135398735 | 143746 | 32 | None | - | 0 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 822 | 4 | 6 | 15 | 4.3 | CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C | 10.1038/s41467-023-40064-9 | |||
136262914 | 143746 | 32 | None | - | 0 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 822 | 4 | 6 | 15 | 4.3 | CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C | 10.1038/s41467-023-40064-9 | |||
CHEMBL374478 | 143746 | 32 | None | - | 0 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 822 | 4 | 6 | 15 | 4.3 | CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C | 10.1038/s41467-023-40064-9 | |||
148192 | 17192 | 81 | None | - | 0 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 704 | 14 | 5 | 9 | 4.2 | COC(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)CN(Cc1ccc(-c2ccccn2)cc1)NC(=O)[C@@H](NC(=O)OC)C(C)(C)C)C(C)(C)C | 10.1038/s41467-023-40064-9 | |||
CHEMBL1163 | 17192 | 81 | None | - | 0 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 704 | 14 | 5 | 9 | 4.2 | COC(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)CN(Cc1ccc(-c2ccccn2)cc1)NC(=O)[C@@H](NC(=O)OC)C(C)(C)C)C(C)(C)C | 10.1038/s41467-023-40064-9 | |||
4150 | 7575 | 39 | None | - | 12 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 314 | 6 | 2 | 2 | 5.8 | CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C | 10.1038/s41467-023-40064-9 | |||
5288 | 7575 | 39 | None | - | 12 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 314 | 6 | 2 | 2 | 5.8 | CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C | 10.1038/s41467-023-40064-9 | |||
644019 | 7575 | 39 | None | - | 12 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 314 | 6 | 2 | 2 | 5.8 | CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C | 10.1038/s41467-023-40064-9 | |||
CHEMBL190461 | 7575 | 39 | None | - | 12 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 314 | 6 | 2 | 2 | 5.8 | CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C | 10.1038/s41467-023-40064-9 | |||
DB09061 | 7575 | 39 | None | - | 12 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 314 | 6 | 2 | 2 | 5.8 | CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C | 10.1038/s41467-023-40064-9 | |||
135564886 | 21265 | 5 | None | - | 0 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 752 | 14 | 1 | 6 | 8.7 | CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 | 10.1038/s41467-023-40064-9 | |||
135673376 | 21265 | 5 | None | - | 0 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 752 | 14 | 1 | 6 | 8.7 | CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 | 10.1038/s41467-023-40064-9 | |||
137157436 | 21265 | 5 | None | - | 0 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 752 | 14 | 1 | 6 | 8.7 | CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 | 10.1038/s41467-023-40064-9 | |||
145948239 | 21265 | 5 | None | - | 0 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 752 | 14 | 1 | 6 | 8.7 | CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 | 10.1038/s41467-023-40064-9 | |||
71587099 | 21265 | 5 | None | - | 0 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 752 | 14 | 1 | 6 | 8.7 | CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 | 10.1038/s41467-023-40064-9 | |||
CHEMBL1201304 | 21265 | 5 | None | - | 0 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 752 | 14 | 1 | 6 | 8.7 | CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 | 10.1038/s41467-023-40064-9 | |||
2540 | 11173 | 111 | None | - | 4 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 610 | 10 | 1 | 11 | 6.3 | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1038/s41467-023-40064-9 | |||
CHEMBL1014 | 11173 | 111 | None | - | 4 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 610 | 10 | 1 | 11 | 6.3 | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1038/s41467-023-40064-9 | |||
2179 | 174297 | 76 | None | - | 0 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 393 | 5 | 2 | 5 | 4.5 | COc1cc(NS(C)(=O)=O)ccc1Nc1c2ccccc2nc2ccccc12 | 10.1038/s41467-023-40064-9 | |||
CHEMBL1256655 | 174297 | 76 | None | - | 0 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 393 | 5 | 2 | 5 | 4.5 | COc1cc(NS(C)(=O)=O)ccc1Nc1c2ccccc2nc2ccccc12 | 10.1038/s41467-023-40064-9 | |||
CHEMBL43 | 174297 | 76 | None | - | 0 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 393 | 5 | 2 | 5 | 4.5 | COc1cc(NS(C)(=O)=O)ccc1Nc1c2ccccc2nc2ccccc12 | 10.1038/s41467-023-40064-9 | |||
2351 | 11072 | 49 | None | - | 0 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 366 | 10 | 0 | 3 | 4.8 | CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1 | 10.1038/s41467-023-40064-9 | |||
CHEMBL1008 | 11072 | 49 | None | - | 0 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 366 | 10 | 0 | 3 | 4.8 | CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1 | 10.1038/s41467-023-40064-9 | |||
CHEMBL1257078 | 11072 | 49 | None | - | 0 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 366 | 10 | 0 | 3 | 4.8 | CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1 | 10.1038/s41467-023-40064-9 | |||
30323 | 69259 | 57 | None | - | 0 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 527 | 4 | 5 | 11 | 1.0 | COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(C)=O)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 | 10.1038/s41467-023-40064-9 | |||
CHEMBL1563 | 69259 | 57 | None | - | 0 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 527 | 4 | 5 | 11 | 1.0 | COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(C)=O)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 | 10.1038/s41467-023-40064-9 | |||
CHEMBL178 | 69259 | 57 | None | - | 0 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 527 | 4 | 5 | 11 | 1.0 | COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(C)=O)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 | 10.1038/s41467-023-40064-9 | |||
2583 | 10548 | 118 | None | - | 1 | Human | 5.6 | pAC50 | = | 5.6 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1038/s41467-023-40064-9 | |||
592 | 10548 | 118 | None | - | 1 | Human | 5.6 | pAC50 | = | 5.6 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1038/s41467-023-40064-9 | |||
65999 | 10548 | 118 | None | - | 1 | Human | 5.6 | pAC50 | = | 5.6 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1038/s41467-023-40064-9 | |||
CHEMBL1017 | 10548 | 118 | None | - | 1 | Human | 5.6 | pAC50 | = | 5.6 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1038/s41467-023-40064-9 | |||
DB00966 | 10548 | 118 | None | - | 1 | Human | 5.6 | pAC50 | = | 5.6 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1038/s41467-023-40064-9 | |||
123879 | 10060 | 82 | None | - | 4 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 416 | 6 | 2 | 4 | 3.1 | OC(=O)CCn1c2CC[C@H](Cc2c2c1cccc2)NS(=O)(=O)c1ccc(cc1)F | 10.1038/s41467-023-40064-9 | |||
1910 | 10060 | 82 | None | - | 4 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 416 | 6 | 2 | 4 | 3.1 | OC(=O)CCn1c2CC[C@H](Cc2c2c1cccc2)NS(=O)(=O)c1ccc(cc1)F | 10.1038/s41467-023-40064-9 | |||
1911 | 10060 | 82 | None | - | 4 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 416 | 6 | 2 | 4 | 3.1 | OC(=O)CCn1c2CC[C@H](Cc2c2c1cccc2)NS(=O)(=O)c1ccc(cc1)F | 10.1038/s41467-023-40064-9 | |||
2354 | 10060 | 82 | None | - | 4 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 416 | 6 | 2 | 4 | 3.1 | OC(=O)CCn1c2CC[C@H](Cc2c2c1cccc2)NS(=O)(=O)c1ccc(cc1)F | 10.1038/s41467-023-40064-9 | |||
CHEMBL361812 | 10060 | 82 | None | - | 4 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 416 | 6 | 2 | 4 | 3.1 | OC(=O)CCn1c2CC[C@H](Cc2c2c1cccc2)NS(=O)(=O)c1ccc(cc1)F | 10.1038/s41467-023-40064-9 | |||
DB13036 | 10060 | 82 | None | - | 4 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 416 | 6 | 2 | 4 | 3.1 | OC(=O)CCn1c2CC[C@H](Cc2c2c1cccc2)NS(=O)(=O)c1ccc(cc1)F | 10.1038/s41467-023-40064-9 | |||
54682461 | 91461 | 62 | None | - | 0 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 602 | 11 | 2 | 6 | 7.3 | CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)C(=O)O1 | 10.1038/s41467-023-40064-9 | |||
CHEMBL222559 | 91461 | 62 | None | - | 0 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 602 | 11 | 2 | 6 | 7.3 | CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)C(=O)O1 | 10.1038/s41467-023-40064-9 | |||
CHEMBL2103737 | 84915 | 0 | None | - | 0 | Human | 4.5 | pAC50 | = | 4.5 | Binding | ChEMBL | None | None | None | None | 10.1038/s41467-023-40064-9 | |||||
8550 | 21196 | 57 | None | - | 0 | Human | 4.5 | pAC50 | = | 4.5 | Binding | ChEMBL | 578 | 7 | 1 | 9 | 4.2 | COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5ccccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC | 10.1038/s41467-023-40064-9 | |||
CHEMBL1200515 | 21196 | 57 | None | - | 0 | Human | 4.5 | pAC50 | = | 4.5 | Binding | ChEMBL | 578 | 7 | 1 | 9 | 4.2 | COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5ccccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC | 10.1038/s41467-023-40064-9 | |||
4846 | 34760 | 53 | None | - | 0 | Human | 5.3 | pAC50 | = | 5.3 | Binding | ChEMBL | 308 | 1 | 2 | 6 | 2.2 | O=C(O)c1cc(O)c2c3nc4ccccc4oc-3cc(=O)c2n1 | 10.1038/s41467-023-40064-9 | |||
CHEMBL1372341 | 34760 | 53 | None | - | 0 | Human | 5.3 | pAC50 | = | 5.3 | Binding | ChEMBL | 308 | 1 | 2 | 6 | 2.2 | O=C(O)c1cc(O)c2c3nc4ccccc4oc-3cc(=O)c2n1 | 10.1038/s41467-023-40064-9 | |||
4495 | 203314 | 92 | None | - | 29 | Human | 5.2 | pAC50 | = | 5.2 | Binding | ChEMBL | 308 | 5 | 1 | 5 | 2.8 | CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1 | 10.1038/s41467-023-40064-9 | |||
CHEMBL56367 | 203314 | 92 | None | - | 29 | Human | 5.2 | pAC50 | = | 5.2 | Binding | ChEMBL | 308 | 5 | 1 | 5 | 2.8 | CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1 | 10.1038/s41467-023-40064-9 | |||
16362 | 9899 | 71 | None | - | 29 | Human | 5.2 | pAC50 | = | 5.2 | Binding | ChEMBL | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | 10.1038/s41467-023-40064-9 | |||
2172 | 9899 | 71 | None | - | 29 | Human | 5.2 | pAC50 | = | 5.2 | Binding | ChEMBL | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | 10.1038/s41467-023-40064-9 | |||
90 | 9899 | 71 | None | - | 29 | Human | 5.2 | pAC50 | = | 5.2 | Binding | ChEMBL | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | 10.1038/s41467-023-40064-9 | |||
CHEMBL1423 | 9899 | 71 | None | - | 29 | Human | 5.2 | pAC50 | = | 5.2 | Binding | ChEMBL | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | 10.1038/s41467-023-40064-9 | |||
DB01100 | 9899 | 71 | None | - | 29 | Human | 5.2 | pAC50 | = | 5.2 | Binding | ChEMBL | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | 10.1038/s41467-023-40064-9 | |||
41684 | 37995 | 105 | None | - | 0 | Human | 5.2 | pAC50 | = | 5.2 | Binding | ChEMBL | 307 | 4 | 1 | 7 | 2.2 | CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1 | 10.1038/s41467-023-40064-9 | |||
CHEMBL1401 | 37995 | 105 | None | - | 0 | Human | 5.2 | pAC50 | = | 5.2 | Binding | ChEMBL | 307 | 4 | 1 | 7 | 2.2 | CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1 | 10.1038/s41467-023-40064-9 | |||
5329102 | 201505 | 86 | None | - | 0 | Human | 5.2 | pAC50 | = | 5.2 | Binding | ChEMBL | 398 | 7 | 3 | 3 | 3.3 | CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C | 10.1038/s41467-023-40064-9 | |||
CHEMBL535 | 201505 | 86 | None | - | 0 | Human | 5.2 | pAC50 | = | 5.2 | Binding | ChEMBL | 398 | 7 | 3 | 3 | 3.3 | CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C | 10.1038/s41467-023-40064-9 | |||
71496458 | 122342 | 87 | None | - | 0 | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 499 | 10 | 2 | 8 | 4.5 | C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C | 10.1038/s41467-023-40064-9 | |||
CHEMBL3353410 | 122342 | 87 | None | - | 0 | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 499 | 10 | 2 | 8 | 4.5 | C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C | 10.1038/s41467-023-40064-9 | |||
176870 | 202264 | 106 | None | - | 0 | Human | 5.0 | pAC50 | = | 5.0 | Binding | ChEMBL | 393 | 10 | 1 | 7 | 3.4 | C#Cc1cccc(Nc2ncnc3cc(OCCOC)c(OCCOC)cc23)c1 | 10.1038/s41467-023-40064-9 | |||
CHEMBL553 | 202264 | 106 | None | - | 0 | Human | 5.0 | pAC50 | = | 5.0 | Binding | ChEMBL | 393 | 10 | 1 | 7 | 3.4 | C#Cc1cccc(Nc2ncnc3cc(OCCOC)c(OCCOC)cc23)c1 | 10.1038/s41467-023-40064-9 | |||
4627 | 7609 | 50 | None | -2 | 5 | Human | 10.0 | pEC50 | = | 10 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00017a022 | |||||
864 | 7609 | 50 | None | -2 | 5 | Human | 10.0 | pEC50 | = | 10 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00017a022 | |||||
9833444 | 7609 | 50 | None | -2 | 5 | Human | 10.0 | pEC50 | = | 10 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00017a022 | |||||
CHEMBL1121 | 7609 | 50 | None | -2 | 5 | Human | 10.0 | pEC50 | = | 10 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00017a022 | |||||
DB09142 | 7609 | 50 | None | -2 | 5 | Human | 10.0 | pEC50 | = | 10 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00017a022 | |||||
10032955 | 174814 | 0 | None | - | 0 | Human | 8.5 | pEC50 | = | 8.5 | Binding | ChEMBL | 742 | 17 | 7 | 6 | 5.8 | Cc1ccccc1NC(=O)NCCCC[C@H](CNC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3)NC(=O)CCC(=O)O | 10.1021/jm00017a022 | |||
CHEMBL432256 | 174814 | 0 | None | - | 0 | Human | 8.5 | pEC50 | = | 8.5 | Binding | ChEMBL | 742 | 17 | 7 | 6 | 5.8 | Cc1ccccc1NC(=O)NCCCC[C@H](CNC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3)NC(=O)CCC(=O)O | 10.1021/jm00017a022 | |||
CHEMBL319438 | 217996 | 0 | None | - | 0 | Human | 8.4 | pEC50 | = | 8.4 | Binding | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00017a022 | |||||
24769604 | 195468 | 0 | None | - | 0 | Human | 11.0 | pIC50 | = | 11 | Binding | ChEMBL | 663 | 9 | 2 | 7 | 6.1 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)C[C@H]3C(=O)NC(C)C)nc2-c2ccc(C)cc2F)c1 | 10.1016/j.bmcl.2008.07.083 | |||
CHEMBL504114 | 195468 | 0 | None | - | 0 | Human | 11.0 | pIC50 | = | 11 | Binding | ChEMBL | 663 | 9 | 2 | 7 | 6.1 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)C[C@H]3C(=O)NC(C)C)nc2-c2ccc(C)cc2F)c1 | 10.1016/j.bmcl.2008.07.083 | |||
44562301 | 195830 | 0 | None | - | 0 | Human | 10.8 | pIC50 | = | 10.8 | Binding | ChEMBL | 645 | 9 | 2 | 7 | 6.0 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)C[C@H]3C(=O)NC(C)C)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | |||
CHEMBL509464 | 195830 | 0 | None | - | 0 | Human | 10.8 | pIC50 | = | 10.8 | Binding | ChEMBL | 645 | 9 | 2 | 7 | 6.0 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)C[C@H]3C(=O)NC(C)C)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | |||
24769546 | 179468 | 0 | None | - | 0 | Human | 10.7 | pIC50 | = | 10.7 | Binding | ChEMBL | 618 | 9 | 2 | 8 | 4.3 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)C[C@H]3C(=O)NCC(=O)O)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | |||
CHEMBL450105 | 179468 | 0 | None | - | 0 | Human | 10.7 | pIC50 | = | 10.7 | Binding | ChEMBL | 618 | 9 | 2 | 8 | 4.3 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)C[C@H]3C(=O)NCC(=O)O)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | |||
24861391 | 195530 | 0 | None | - | 0 | Human | 10.5 | pIC50 | = | 10.5 | Binding | ChEMBL | 578 | 5 | 1 | 7 | 5.3 | O=C(O)c1cc(N2CCN(C(=O)c3cn(-c4ccc5c(c4)OCCO5)c(-c4ccc(F)cc4)n3)CC2)cc2ccccc12 | 10.1016/j.bmcl.2008.06.057 | |||
CHEMBL505225 | 195530 | 0 | None | - | 0 | Human | 10.5 | pIC50 | = | 10.5 | Binding | ChEMBL | 578 | 5 | 1 | 7 | 5.3 | O=C(O)c1cc(N2CCN(C(=O)c3cn(-c4ccc5c(c4)OCCO5)c(-c4ccc(F)cc4)n3)CC2)cc2ccccc12 | 10.1016/j.bmcl.2008.06.057 | |||
CHEMBL505969 | 195530 | 0 | None | - | 0 | Human | 10.5 | pIC50 | = | 10.5 | Binding | ChEMBL | 578 | 5 | 1 | 7 | 5.3 | O=C(O)c1cc(N2CCN(C(=O)c3cn(-c4ccc5c(c4)OCCO5)c(-c4ccc(F)cc4)n3)CC2)cc2ccccc12 | 10.1016/j.bmcl.2008.06.057 | |||
24861394 | 195834 | 0 | None | - | 0 | Human | 10.5 | pIC50 | = | 10.5 | Binding | ChEMBL | 592 | 5 | 1 | 7 | 5.6 | Cc1ccc(-c2nc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)cn2-c2ccc3c(c2)OCCO3)c(F)c1 | 10.1016/j.bmcl.2008.06.057 | |||
CHEMBL509519 | 195834 | 0 | None | - | 0 | Human | 10.5 | pIC50 | = | 10.5 | Binding | ChEMBL | 592 | 5 | 1 | 7 | 5.6 | Cc1ccc(-c2nc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)cn2-c2ccc3c(c2)OCCO3)c(F)c1 | 10.1016/j.bmcl.2008.06.057 | |||
53233689 | 68630 | 0 | None | - | 0 | Human | 10.5 | pIC50 | = | 10.5 | Binding | ChEMBL | 604 | 5 | 1 | 7 | 5.8 | Cc1ccc(-c2nc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)ncc2-c2ccc3c(c2)OCCO3)c(F)c1 | 10.1016/j.bmcl.2011.03.069 | |||
CHEMBL1773877 | 68630 | 0 | None | - | 0 | Human | 10.5 | pIC50 | = | 10.5 | Binding | ChEMBL | 604 | 5 | 1 | 7 | 5.8 | Cc1ccc(-c2nc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)ncc2-c2ccc3c(c2)OCCO3)c(F)c1 | 10.1016/j.bmcl.2011.03.069 | |||
44562306 | 195708 | 0 | None | - | 0 | Human | 10.4 | pIC50 | = | 10.4 | Binding | ChEMBL | 605 | 10 | 1 | 8 | 5.2 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)C[C@@H]3COCC(=O)O)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | |||
CHEMBL508004 | 195708 | 0 | None | - | 0 | Human | 10.4 | pIC50 | = | 10.4 | Binding | ChEMBL | 605 | 10 | 1 | 8 | 5.2 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)C[C@@H]3COCC(=O)O)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | |||
24861060 | 195506 | 0 | None | - | 0 | Human | 10.4 | pIC50 | = | 10.4 | Binding | ChEMBL | 578 | 7 | 1 | 6 | 6.2 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2F)c1 | 10.1016/j.bmcl.2008.07.083 | |||
CHEMBL446789 | 195506 | 0 | None | - | 0 | Human | 10.4 | pIC50 | = | 10.4 | Binding | ChEMBL | 578 | 7 | 1 | 6 | 6.2 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2F)c1 | 10.1016/j.bmcl.2008.07.083 | |||
CHEMBL504861 | 195506 | 0 | None | - | 0 | Human | 10.4 | pIC50 | = | 10.4 | Binding | ChEMBL | 578 | 7 | 1 | 6 | 6.2 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2F)c1 | 10.1016/j.bmcl.2008.07.083 | |||
155543995 | 180102 | 0 | None | - | 0 | Human | 10.4 | pIC50 | = | 10.4 | Binding | ChEMBL | 1876 | 73 | 16 | 22 | 4.2 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL4526455 | 180102 | 0 | None | - | 0 | Human | 10.4 | pIC50 | = | 10.4 | Binding | ChEMBL | 1876 | 73 | 16 | 22 | 4.2 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
44562302 | 194970 | 0 | None | - | 0 | Human | 10.4 | pIC50 | = | 10.4 | Binding | ChEMBL | 666 | 11 | 2 | 8 | 5.7 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)C[C@H]3COCC(=O)O)nc2-c2ccc(C)cc2F)c1 | 10.1016/j.bmcl.2008.07.083 | |||
CHEMBL498958 | 194970 | 0 | None | - | 0 | Human | 10.4 | pIC50 | = | 10.4 | Binding | ChEMBL | 666 | 11 | 2 | 8 | 5.7 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)C[C@H]3COCC(=O)O)nc2-c2ccc(C)cc2F)c1 | 10.1016/j.bmcl.2008.07.083 | |||
155562281 | 182620 | 0 | None | - | 0 | Human | 10.4 | pIC50 | = | 10.4 | Binding | ChEMBL | 1900 | 71 | 16 | 23 | 4.4 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1cccc2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL4585323 | 182620 | 0 | None | - | 0 | Human | 10.4 | pIC50 | = | 10.4 | Binding | ChEMBL | 1900 | 71 | 16 | 23 | 4.4 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1cccc2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
10819755 | 172221 | 0 | None | - | 2 | Human | 10.4 | pIC50 | = | 10.4 | Binding | ChEMBL | 976 | 28 | 9 | 11 | 1.6 | CCCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL423907 | 172221 | 0 | None | - | 2 | Human | 10.4 | pIC50 | = | 10.4 | Binding | ChEMBL | 976 | 28 | 9 | 11 | 1.6 | CCCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL411079 | 219641 | 0 | None | - | 0 | Rat | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N1CSC(C)(C)[C@@H]1C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00100a033 | |||||
121964 | 6995 | 34 | None | 831 | 2 | Rat | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00100a033 | |||||
858 | 6995 | 34 | None | 831 | 2 | Rat | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00100a033 | |||||
CHEMBL323521 | 6995 | 34 | None | 831 | 2 | Rat | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00100a033 | |||||
155543163 | 180065 | 0 | None | - | 0 | Human | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 1886 | 72 | 16 | 25 | 2.5 | CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL4525615 | 180065 | 0 | None | - | 0 | Human | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 1886 | 72 | 16 | 25 | 2.5 | CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
24769605 | 185498 | 0 | None | - | 0 | Human | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 605 | 10 | 1 | 8 | 5.2 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)C[C@H]3COCC(=O)O)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | |||
CHEMBL468372 | 185498 | 0 | None | - | 0 | Human | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 605 | 10 | 1 | 8 | 5.2 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)C[C@H]3COCC(=O)O)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | |||
155514270 | 176649 | 0 | None | - | 0 | Human | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 1848 | 72 | 16 | 22 | 3.6 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL4440419 | 176649 | 0 | None | - | 0 | Human | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 1848 | 72 | 16 | 22 | 3.6 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
24769543 | 195483 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 649 | 9 | 2 | 7 | 5.7 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)C[C@H]3CNC(C)=O)nc2-c2ccc(C)cc2F)c1 | 10.1016/j.bmcl.2008.07.083 | |||
CHEMBL504406 | 195483 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 649 | 9 | 2 | 7 | 5.7 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)C[C@H]3CNC(C)=O)nc2-c2ccc(C)cc2F)c1 | 10.1016/j.bmcl.2008.07.083 | |||
24861060 | 195506 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 578 | 7 | 1 | 6 | 6.2 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2F)c1 | 10.1016/j.bmcl.2008.06.057 | |||
CHEMBL446789 | 195506 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 578 | 7 | 1 | 6 | 6.2 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2F)c1 | 10.1016/j.bmcl.2008.06.057 | |||
CHEMBL504861 | 195506 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 578 | 7 | 1 | 6 | 6.2 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2F)c1 | 10.1016/j.bmcl.2008.06.057 | |||
155539345 | 179612 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 1850 | 72 | 16 | 23 | 3.4 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL4514283 | 179612 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 1850 | 72 | 16 | 23 | 3.4 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
155514432 | 176644 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 2121 | 86 | 19 | 27 | 2.3 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)[C@H](CCCCN)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL4440303 | 176644 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 2121 | 86 | 19 | 27 | 2.3 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)[C@H](CCCCN)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
155540739 | 179286 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 1907 | 74 | 17 | 24 | 2.5 | CCCC[C@H](NC(=O)[C@H](Cc1cc2ccccc2[nH]1)NC(=O)CNC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(C)=O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL4483457 | 179286 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 1907 | 74 | 17 | 24 | 2.5 | CCCC[C@H](NC(=O)[C@H](Cc1cc2ccccc2[nH]1)NC(=O)CNC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(C)=O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
44562303 | 179567 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 685 | 10 | 2 | 8 | 5.1 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)C[C@H]3CNS(C)(=O)=O)nc2-c2ccc(C)cc2F)c1 | 10.1016/j.bmcl.2008.07.083 | |||
CHEMBL451342 | 179567 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 685 | 10 | 2 | 8 | 5.1 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)C[C@H]3CNS(C)(=O)=O)nc2-c2ccc(C)cc2F)c1 | 10.1016/j.bmcl.2008.07.083 | |||
24861114 | 195918 | 5 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 582 | 7 | 1 | 6 | 6.0 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(F)cc2F)c1 | 10.1016/j.bmcl.2008.06.057 | |||
CHEMBL510690 | 195918 | 5 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 582 | 7 | 1 | 6 | 6.0 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(F)cc2F)c1 | 10.1016/j.bmcl.2008.06.057 | |||
155515427 | 176728 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 1886 | 72 | 17 | 23 | 4.2 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL4441596 | 176728 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 1886 | 72 | 17 | 23 | 4.2 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
155566319 | 182519 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 1850 | 71 | 16 | 23 | 3.2 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL4583158 | 182519 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 1850 | 71 | 16 | 23 | 3.2 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
155559320 | 181643 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 1872 | 72 | 18 | 23 | 3.8 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL4563364 | 181643 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 1872 | 72 | 18 | 23 | 3.8 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
443375 | 214385 | 45 | None | -3 | 5 | Rat | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00047a021 | |||
CHEMBL9506 | 214385 | 45 | None | -3 | 5 | Rat | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00047a021 | |||
155547906 | 180455 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 1848 | 72 | 16 | 22 | 3.6 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)C[C@H](NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL4534977 | 180455 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 1848 | 72 | 16 | 22 | 3.6 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)C[C@H](NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
155560670 | 181871 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 1886 | 72 | 17 | 23 | 4.2 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL4568746 | 181871 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 1886 | 72 | 17 | 23 | 4.2 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
443375 | 214385 | 45 | None | -3 | 5 | Rat | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(00)80683-6 | |||
CHEMBL9506 | 214385 | 45 | None | -3 | 5 | Rat | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(00)80683-6 | |||
443375 | 214385 | 45 | None | -3 | 5 | Rat | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm020424z | |||
CHEMBL9506 | 214385 | 45 | None | -3 | 5 | Rat | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm020424z | |||
443375 | 214385 | 45 | None | -3 | 5 | Rat | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00121a004 | |||
CHEMBL9506 | 214385 | 45 | None | -3 | 5 | Rat | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00121a004 | |||
443375 | 214385 | 45 | None | -3 | 5 | Rat | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm000937a | |||
CHEMBL9506 | 214385 | 45 | None | -3 | 5 | Rat | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm000937a | |||
443375 | 214385 | 45 | None | -3 | 5 | Rat | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL9506 | 214385 | 45 | None | -3 | 5 | Rat | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
443375 | 214385 | 45 | None | -3 | 5 | Rat | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00609-9 | |||
CHEMBL9506 | 214385 | 45 | None | -3 | 5 | Rat | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00609-9 | |||
443375 | 214385 | 45 | None | -3 | 5 | Rat | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00164a020 | |||
CHEMBL9506 | 214385 | 45 | None | -3 | 5 | Rat | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00164a020 | |||
443375 | 214385 | 45 | None | -2 | 5 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/np9800102 | |||
CHEMBL9506 | 214385 | 45 | None | -2 | 5 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/np9800102 | |||
24861113 | 194969 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 564 | 7 | 1 | 6 | 5.9 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(F)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
CHEMBL498942 | 194969 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 564 | 7 | 1 | 6 | 5.9 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(F)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
CHEMBL506201 | 194969 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 564 | 7 | 1 | 6 | 5.9 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(F)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
44562297 | 195402 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 631 | 9 | 2 | 7 | 5.6 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)C[C@@H]3CNC(C)=O)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | |||
CHEMBL502974 | 195402 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 631 | 9 | 2 | 7 | 5.6 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)C[C@@H]3CNC(C)=O)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | |||
44562299 | 195648 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 646 | 9 | 3 | 7 | 5.4 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)C[C@@H]3CNC(=O)NC)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | |||
CHEMBL507051 | 195648 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 646 | 9 | 3 | 7 | 5.4 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)C[C@@H]3CNC(=O)NC)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | |||
443375 | 214385 | 45 | None | -3 | 5 | Rat | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(00)80684-8 | |||
CHEMBL9506 | 214385 | 45 | None | -3 | 5 | Rat | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(00)80684-8 | |||
155536333 | 178951 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 1865 | 71 | 17 | 24 | 1.3 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(N)=O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL4473468 | 178951 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 1865 | 71 | 17 | 24 | 1.3 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(N)=O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
155555346 | 181151 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 1836 | 71 | 17 | 23 | 2.9 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL4551834 | 181151 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 1836 | 71 | 17 | 23 | 2.9 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
155535579 | 178829 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 1836 | 71 | 17 | 23 | 2.9 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL4471871 | 178829 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 1836 | 71 | 17 | 23 | 2.9 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
44398261 | 131164 | 0 | None | - | 0 | Rat | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 577 | 7 | 4 | 6 | 4.2 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(S)N(Cc3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm0501127 | |||
CHEMBL363916 | 131164 | 0 | None | - | 0 | Rat | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 577 | 7 | 4 | 6 | 4.2 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(S)N(Cc3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm0501127 | |||
10460766 | 122234 | 0 | None | - | 0 | Rat | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 575 | 7 | 3 | 5 | 4.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=S)N(Cc3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm010898i | |||
CHEMBL3350858 | 122234 | 0 | None | - | 0 | Rat | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 575 | 7 | 3 | 5 | 4.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=S)N(Cc3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm010898i | |||
44562304 | 195654 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 664 | 9 | 3 | 7 | 5.5 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)C[C@H]3CNC(=O)NC)nc2-c2ccc(C)cc2F)c1 | 10.1016/j.bmcl.2008.07.083 | |||
CHEMBL507094 | 195654 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 664 | 9 | 3 | 7 | 5.5 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)C[C@H]3CNC(=O)NC)nc2-c2ccc(C)cc2F)c1 | 10.1016/j.bmcl.2008.07.083 | |||
155555065 | 181113 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 1836 | 71 | 17 | 23 | 2.9 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL4550876 | 181113 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 1836 | 71 | 17 | 23 | 2.9 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL269098 | 217557 | 0 | None | - | 0 | Rat | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCC(=O)N[C@@H](Cc1cc2ccccc2[nH]1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/S0960-894X(01)81250-6 | |||||
4627 | 7609 | 50 | None | -1 | 5 | Rat | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00092a007 | |||||
864 | 7609 | 50 | None | -1 | 5 | Rat | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00092a007 | |||||
9833444 | 7609 | 50 | None | -1 | 5 | Rat | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00092a007 | |||||
CHEMBL1121 | 7609 | 50 | None | -1 | 5 | Rat | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00092a007 | |||||
DB09142 | 7609 | 50 | None | -1 | 5 | Rat | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00092a007 | |||||
4627 | 7609 | 50 | None | -1 | 5 | Rat | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00105a062 | |||||
864 | 7609 | 50 | None | -1 | 5 | Rat | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00105a062 | |||||
9833444 | 7609 | 50 | None | -1 | 5 | Rat | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00105a062 | |||||
CHEMBL1121 | 7609 | 50 | None | -1 | 5 | Rat | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00105a062 | |||||
DB09142 | 7609 | 50 | None | -1 | 5 | Rat | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00105a062 | |||||
443375 | 214385 | 45 | None | -3 | 5 | Rat | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00105a062 | |||
CHEMBL9506 | 214385 | 45 | None | -3 | 5 | Rat | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00105a062 | |||
4627 | 7609 | 50 | None | -1 | 5 | Rat | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(00)80687-3 | |||||
864 | 7609 | 50 | None | -1 | 5 | Rat | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(00)80687-3 | |||||
9833444 | 7609 | 50 | None | -1 | 5 | Rat | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(00)80687-3 | |||||
CHEMBL1121 | 7609 | 50 | None | -1 | 5 | Rat | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(00)80687-3 | |||||
DB09142 | 7609 | 50 | None | -1 | 5 | Rat | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(00)80687-3 | |||||
443375 | 214385 | 45 | None | -3 | 5 | Rat | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(00)80687-3 | |||
CHEMBL9506 | 214385 | 45 | None | -3 | 5 | Rat | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(00)80687-3 | |||
4627 | 7609 | 50 | None | -1 | 5 | Rat | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00057a005 | |||||
864 | 7609 | 50 | None | -1 | 5 | Rat | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00057a005 | |||||
9833444 | 7609 | 50 | None | -1 | 5 | Rat | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00057a005 | |||||
CHEMBL1121 | 7609 | 50 | None | -1 | 5 | Rat | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00057a005 | |||||
DB09142 | 7609 | 50 | None | -1 | 5 | Rat | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00057a005 | |||||
443375 | 214385 | 45 | None | -3 | 5 | Rat | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00057a005 | |||
CHEMBL9506 | 214385 | 45 | None | -3 | 5 | Rat | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00057a005 | |||
155532759 | 178534 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 1431 | 50 | 12 | 15 | 5.6 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL4467402 | 178534 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 1431 | 50 | 12 | 15 | 5.6 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
155517239 | 176936 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 2582 | 122 | 16 | 39 | 4.4 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL4444353 | 176936 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 2582 | 122 | 16 | 39 | 4.4 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
44562300 | 195416 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 645 | 9 | 2 | 7 | 6.0 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)C[C@@H]3C(=O)NC(C)C)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | |||
CHEMBL503107 | 195416 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 645 | 9 | 2 | 7 | 6.0 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)C[C@@H]3C(=O)NC(C)C)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | |||
4627 | 7609 | 50 | None | -2 | 5 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b01558 | |||||
864 | 7609 | 50 | None | -2 | 5 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b01558 | |||||
9833444 | 7609 | 50 | None | -2 | 5 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b01558 | |||||
CHEMBL1121 | 7609 | 50 | None | -2 | 5 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b01558 | |||||
DB09142 | 7609 | 50 | None | -2 | 5 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b01558 | |||||
155517761 | 177002 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 1900 | 71 | 16 | 23 | 4.4 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1cccc2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL4445529 | 177002 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 1900 | 71 | 16 | 23 | 4.4 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1cccc2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
72548703 | 168346 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 583 | 8 | 3 | 6 | 5.8 | CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 | 10.1016/j.bmcl.2018.03.093 | |||
CHEMBL4128926 | 168346 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 583 | 8 | 3 | 6 | 5.8 | CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 | 10.1016/j.bmcl.2018.03.093 | |||
44562298 | 178230 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 667 | 10 | 2 | 8 | 5.0 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)C[C@@H]3CNS(C)(=O)=O)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | |||
CHEMBL446324 | 178230 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 667 | 10 | 2 | 8 | 5.0 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)C[C@@H]3CNS(C)(=O)=O)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | |||
44578764 | 187591 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 535 | 4 | 0 | 7 | 5.0 | O=C(c1cn(-c2ccc3c(c2)OCCO3)c(-c2ccc(F)cc2)n1)N1CCN(c2cnc3ccccc3c2)CC1 | 10.1016/j.bmcl.2008.06.057 | |||
CHEMBL475679 | 187591 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 535 | 4 | 0 | 7 | 5.0 | O=C(c1cn(-c2ccc3c(c2)OCCO3)c(-c2ccc(F)cc2)n1)N1CCN(c2cnc3ccccc3c2)CC1 | 10.1016/j.bmcl.2008.06.057 | |||
16755781 | 195564 | 12 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 560 | 7 | 1 | 6 | 6.1 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
16755781 | 195564 | 12 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 560 | 7 | 1 | 6 | 6.1 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | |||
CHEMBL443189 | 195564 | 12 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 560 | 7 | 1 | 6 | 6.1 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
CHEMBL443189 | 195564 | 12 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 560 | 7 | 1 | 6 | 6.1 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | |||
CHEMBL505409 | 195564 | 12 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 560 | 7 | 1 | 6 | 6.1 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
CHEMBL505409 | 195564 | 12 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 560 | 7 | 1 | 6 | 6.1 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | |||
CHEMBL505727 | 195564 | 12 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 560 | 7 | 1 | 6 | 6.1 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
CHEMBL505727 | 195564 | 12 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 560 | 7 | 1 | 6 | 6.1 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | |||
4627 | 7609 | 50 | None | -2 | 5 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.03.006 | |||||
864 | 7609 | 50 | None | -2 | 5 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.03.006 | |||||
9833444 | 7609 | 50 | None | -2 | 5 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.03.006 | |||||
CHEMBL1121 | 7609 | 50 | None | -2 | 5 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.03.006 | |||||
DB09142 | 7609 | 50 | None | -2 | 5 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.03.006 | |||||
4627 | 7609 | 50 | None | -2 | 5 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | |||||
864 | 7609 | 50 | None | -2 | 5 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | |||||
9833444 | 7609 | 50 | None | -2 | 5 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | |||||
CHEMBL1121 | 7609 | 50 | None | -2 | 5 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | |||||
DB09142 | 7609 | 50 | None | -2 | 5 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | |||||
44578457 | 179250 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 546 | 6 | 1 | 6 | 5.7 | COc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
CHEMBL448221 | 179250 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 546 | 6 | 1 | 6 | 5.7 | COc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
24861392 | 179697 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 574 | 5 | 1 | 7 | 5.4 | Cc1ccc(-c2nc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)cn2-c2ccc3c(c2)OCCO3)cc1 | 10.1016/j.bmcl.2008.06.057 | |||
CHEMBL451644 | 179697 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 574 | 5 | 1 | 7 | 5.4 | Cc1ccc(-c2nc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)cn2-c2ccc3c(c2)OCCO3)cc1 | 10.1016/j.bmcl.2008.06.057 | |||
44562296 | 195782 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 648 | 11 | 2 | 8 | 5.5 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)C[C@@H]3COCC(=O)O)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | |||
CHEMBL508772 | 195782 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 648 | 11 | 2 | 8 | 5.5 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)C[C@@H]3COCC(=O)O)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | |||
155552556 | 180847 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 1792 | 67 | 16 | 22 | 1.9 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL4544208 | 180847 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 1792 | 67 | 16 | 22 | 1.9 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
54586148 | 68642 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 543 | 4 | 0 | 7 | 5.4 | Cc1ccc(-c2nc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)ncc2-c2ccc3c(c2)OCCO3)cc1 | 10.1016/j.bmcl.2011.03.069 | |||
CHEMBL1773891 | 68642 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 543 | 4 | 0 | 7 | 5.4 | Cc1ccc(-c2nc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)ncc2-c2ccc3c(c2)OCCO3)cc1 | 10.1016/j.bmcl.2011.03.069 | |||
155542488 | 179913 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 1820 | 69 | 16 | 22 | 2.6 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL4520976 | 179913 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 1820 | 69 | 16 | 22 | 2.6 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL413654 | 219858 | 0 | None | - | 2 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | None | None | None | CSCC[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@H](CC(=O)O)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/jm00378a012 | |||||
13822923 | 201595 | 0 | None | - | 0 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 450 | 3 | 2 | 5 | 4.5 | Cc1nnc2n1-c1ccccc1C(c1ccccc1F)=NC2NC(=O)c1cc2ccccc2[nH]1 | 10.1021/jm00396a028 | |||
CHEMBL53907 | 201595 | 0 | None | - | 0 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 450 | 3 | 2 | 5 | 4.5 | Cc1nnc2n1-c1ccccc1C(c1ccccc1F)=NC2NC(=O)c1cc2ccccc2[nH]1 | 10.1021/jm00396a028 | |||
44578729 | 196410 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 531 | 4 | 0 | 7 | 5.1 | Cc1ccc(-c2nc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)cn2-c2ccc3c(c2)OCCO3)cc1 | 10.1016/j.bmcl.2008.06.057 | |||
CHEMBL514953 | 196410 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 531 | 4 | 0 | 7 | 5.1 | Cc1ccc(-c2nc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)cn2-c2ccc3c(c2)OCCO3)cc1 | 10.1016/j.bmcl.2008.06.057 | |||
44562310 | 179432 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 602 | 8 | 1 | 7 | 5.7 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)C[C@@H]3C(=O)NC(C)C)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | |||
CHEMBL449681 | 179432 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 602 | 8 | 1 | 7 | 5.7 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)C[C@@H]3C(=O)NC(C)C)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | |||
46869398 | 68698 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 576 | 6 | 1 | 6 | 6.1 | COc1ccc(-c2cnc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2F)cc1 | 10.1016/j.bmcl.2011.03.069 | |||
CHEMBL1774043 | 68698 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 576 | 6 | 1 | 6 | 6.1 | COc1ccc(-c2cnc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2F)cc1 | 10.1016/j.bmcl.2011.03.069 | |||
44578728 | 186237 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 535 | 6 | 0 | 6 | 5.9 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(C)cc2F)c1 | 10.1016/j.bmcl.2008.06.057 | |||
CHEMBL474067 | 186237 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 535 | 6 | 0 | 6 | 5.9 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(C)cc2F)c1 | 10.1016/j.bmcl.2008.06.057 | |||
44562305 | 195399 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 589 | 8 | 0 | 8 | 5.7 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)C[C@@H]3COC(C)=O)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | |||
CHEMBL502924 | 195399 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 589 | 8 | 0 | 8 | 5.7 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)C[C@@H]3COC(C)=O)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | |||
44562314 | 195541 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 602 | 8 | 1 | 7 | 5.7 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)C[C@H]3C(=O)NC(C)C)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | |||
CHEMBL505432 | 195541 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 602 | 8 | 1 | 7 | 5.7 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)C[C@H]3C(=O)NC(C)C)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | |||
155516677 | 176868 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 1822 | 72 | 18 | 23 | 2.7 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL4443415 | 176868 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 1822 | 72 | 18 | 23 | 2.7 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
155524181 | 177632 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 1820 | 71 | 18 | 22 | 2.7 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL4453982 | 177632 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 1820 | 71 | 18 | 22 | 2.7 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
14888734 | 174625 | 0 | None | - | 0 | Rat | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 1012 | 29 | 10 | 13 | 0.8 | CSCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00107a037 | |||
CHEMBL430906 | 174625 | 0 | None | - | 0 | Rat | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 1012 | 29 | 10 | 13 | 0.8 | CSCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00107a037 | |||
44562307 | 179485 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 588 | 8 | 1 | 7 | 5.3 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)C[C@@H]3CNC(C)=O)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | |||
CHEMBL450443 | 179485 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 588 | 8 | 1 | 7 | 5.3 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)C[C@@H]3CNC(C)=O)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | |||
54583296 | 68688 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 533 | 5 | 0 | 6 | 5.8 | COc1ccc(-c2cnc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(C)cc2F)cc1 | 10.1016/j.bmcl.2011.03.069 | |||
CHEMBL1774033 | 68688 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 533 | 5 | 0 | 6 | 5.8 | COc1ccc(-c2cnc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(C)cc2F)cc1 | 10.1016/j.bmcl.2011.03.069 | |||
10477146 | 85288 | 1 | None | - | 0 | Rat | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 418 | 3 | 2 | 3 | 4.3 | CN1C(=O)[C@@H](NC(=O)Nc2ccccc2Cl)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL2111920 | 85288 | 1 | None | - | 0 | Rat | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 418 | 3 | 2 | 3 | 4.3 | CN1C(=O)[C@@H](NC(=O)Nc2ccccc2Cl)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
155568312 | 182857 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 1836 | 72 | 17 | 23 | 3.0 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL4591101 | 182857 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 1836 | 72 | 17 | 23 | 3.0 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
155544674 | 181715 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 1822 | 71 | 18 | 23 | 2.5 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL4565336 | 181715 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 1822 | 71 | 18 | 23 | 2.5 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
4627 | 7609 | 50 | None | -1 | 5 | Guinea pig | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(00)80680-0 | |||||
864 | 7609 | 50 | None | -1 | 5 | Guinea pig | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(00)80680-0 | |||||
9833444 | 7609 | 50 | None | -1 | 5 | Guinea pig | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(00)80680-0 | |||||
CHEMBL1121 | 7609 | 50 | None | -1 | 5 | Guinea pig | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(00)80680-0 | |||||
DB09142 | 7609 | 50 | None | -1 | 5 | Guinea pig | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(00)80680-0 | |||||
14208286 | 74458 | 0 | None | - | 0 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 395 | 4 | 1 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)/C=C/c2ccccc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL1907661 | 74458 | 0 | None | - | 0 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 395 | 4 | 1 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)/C=C/c2ccccc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
155537344 | 179097 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 1848 | 72 | 16 | 22 | 3.6 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL4475304 | 179097 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 1848 | 72 | 16 | 22 | 3.6 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
155535107 | 178793 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 1904 | 73 | 19 | 22 | 4.7 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL4471525 | 178793 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 1904 | 73 | 19 | 22 | 4.7 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
4627 | 7609 | 50 | None | -2 | 5 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm8007618 | |||||
864 | 7609 | 50 | None | -2 | 5 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm8007618 | |||||
9833444 | 7609 | 50 | None | -2 | 5 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm8007618 | |||||
CHEMBL1121 | 7609 | 50 | None | -2 | 5 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm8007618 | |||||
DB09142 | 7609 | 50 | None | -2 | 5 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm8007618 | |||||
4627 | 7609 | 50 | None | -2 | 5 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00017a022 | |||||
864 | 7609 | 50 | None | -2 | 5 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00017a022 | |||||
9833444 | 7609 | 50 | None | -2 | 5 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00017a022 | |||||
CHEMBL1121 | 7609 | 50 | None | -2 | 5 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00017a022 | |||||
DB09142 | 7609 | 50 | None | -2 | 5 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00017a022 | |||||
14208241 | 74525 | 0 | None | - | 0 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 421 | 3 | 1 | 3 | 4.0 | CN1C(=O)[C@@H](NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00121a004 | |||
CHEMBL1907852 | 74525 | 0 | None | - | 0 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 421 | 3 | 1 | 3 | 4.0 | CN1C(=O)[C@@H](NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00121a004 | |||
44562312 | 195424 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 588 | 8 | 1 | 7 | 5.3 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)C[C@H]3CNC(C)=O)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | |||
CHEMBL503331 | 195424 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 588 | 8 | 1 | 7 | 5.3 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)C[C@H]3CNC(C)=O)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | |||
14208244 | 65642 | 0 | None | - | 0 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 403 | 3 | 1 | 3 | 3.9 | CN1C(=O)[C@@H](NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(00)80684-8 | |||
CHEMBL168852 | 65642 | 0 | None | - | 0 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 403 | 3 | 1 | 3 | 3.9 | CN1C(=O)[C@@H](NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(00)80684-8 | |||
4627 | 7609 | 50 | None | -2 | 5 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00001a027 | |||||
864 | 7609 | 50 | None | -2 | 5 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00001a027 | |||||
9833444 | 7609 | 50 | None | -2 | 5 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00001a027 | |||||
CHEMBL1121 | 7609 | 50 | None | -2 | 5 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00001a027 | |||||
DB09142 | 7609 | 50 | None | -2 | 5 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00001a027 | |||||
4627 | 7609 | 50 | None | -1 | 5 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00173a006 | |||||
864 | 7609 | 50 | None | -1 | 5 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00173a006 | |||||
9833444 | 7609 | 50 | None | -1 | 5 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00173a006 | |||||
CHEMBL1121 | 7609 | 50 | None | -1 | 5 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00173a006 | |||||
DB09142 | 7609 | 50 | None | -1 | 5 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00173a006 | |||||
24785705 | 189065 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 530 | 4 | 0 | 6 | 5.7 | Cc1ccc(-c2nc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)cn2-c2ccc3c(c2)OCCO3)cc1 | 10.1016/j.bmcl.2008.06.057 | |||
CHEMBL478398 | 189065 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 530 | 4 | 0 | 6 | 5.7 | Cc1ccc(-c2nc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)cn2-c2ccc3c(c2)OCCO3)cc1 | 10.1016/j.bmcl.2008.06.057 | |||
44562308 | 179435 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 624 | 9 | 1 | 8 | 4.7 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)C[C@@H]3CNS(C)(=O)=O)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | |||
CHEMBL449725 | 179435 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 624 | 9 | 1 | 8 | 4.7 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)C[C@@H]3CNS(C)(=O)=O)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | |||
44578767 | 180295 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 517 | 6 | 0 | 6 | 5.8 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
44578767 | 180295 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 517 | 6 | 0 | 6 | 5.8 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | |||
CHEMBL453083 | 180295 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 517 | 6 | 0 | 6 | 5.8 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
CHEMBL453083 | 180295 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 517 | 6 | 0 | 6 | 5.8 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | |||
CHEMBL503822 | 180295 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 517 | 6 | 0 | 6 | 5.8 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
CHEMBL503822 | 180295 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 517 | 6 | 0 | 6 | 5.8 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | |||
6957640 | 166140 | 0 | None | - | 0 | Rat | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 404 | 3 | 2 | 3 | 4.5 | Cc1cccc(NC(=O)N[C@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(01)80987-2 | |||
CHEMBL410035 | 166140 | 0 | None | - | 0 | Rat | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 404 | 3 | 2 | 3 | 4.5 | Cc1cccc(NC(=O)N[C@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(01)80987-2 | |||
44396718 | 74173 | 0 | None | - | 0 | Rat | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 530 | 7 | 2 | 5 | 4.6 | C[C@@H]1C(=O)N(Cc2ccccc2)C(=O)N2CCC[C@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC(C)(C)C)C12 | 10.1021/jm0498755 | |||
CHEMBL188808 | 74173 | 0 | None | - | 0 | Rat | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 530 | 7 | 2 | 5 | 4.6 | C[C@@H]1C(=O)N(Cc2ccccc2)C(=O)N2CCC[C@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC(C)(C)C)C12 | 10.1021/jm0498755 | |||
44562311 | 195497 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 589 | 8 | 0 | 8 | 5.7 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)C[C@H]3COC(C)=O)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | |||
CHEMBL504707 | 195497 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 589 | 8 | 0 | 8 | 5.7 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)C[C@H]3COC(C)=O)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | |||
155557064 | 181371 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 1998 | 75 | 18 | 24 | 4.5 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1C)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL4557012 | 181371 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 1998 | 75 | 18 | 24 | 4.5 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1C)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
443375 | 214385 | 45 | None | -2 | 5 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm701575k | |||
CHEMBL9506 | 214385 | 45 | None | -2 | 5 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm701575k | |||
4627 | 7609 | 50 | None | -1 | 5 | Rat | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00079a003 | |||||
864 | 7609 | 50 | None | -1 | 5 | Rat | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00079a003 | |||||
9833444 | 7609 | 50 | None | -1 | 5 | Rat | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00079a003 | |||||
CHEMBL1121 | 7609 | 50 | None | -1 | 5 | Rat | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00079a003 | |||||
DB09142 | 7609 | 50 | None | -1 | 5 | Rat | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00079a003 | |||||
6918156 | 104063 | 4 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 990 | 29 | 9 | 11 | 2.0 | CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00094a001 | |||
CHEMBL269016 | 104063 | 4 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 990 | 29 | 9 | 11 | 2.0 | CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00094a001 | |||
6918156 | 104063 | 4 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 990 | 29 | 9 | 11 | 2.0 | CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00031a013 | |||
CHEMBL269016 | 104063 | 4 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 990 | 29 | 9 | 11 | 2.0 | CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00031a013 | |||
155530671 | 178341 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 1627 | 65 | 14 | 19 | 4.1 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](CCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)NC(=O)Cc1ccc(O)cc1)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL4464703 | 178341 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 1627 | 65 | 14 | 19 | 4.1 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](CCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)NC(=O)Cc1ccc(O)cc1)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
155524770 | 177717 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 1641 | 66 | 14 | 19 | 4.5 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)NC(=O)Cc1ccc(O)cc1)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL4455361 | 177717 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 1641 | 66 | 14 | 19 | 4.5 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)NC(=O)Cc1ccc(O)cc1)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
44562309 | 178361 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 603 | 8 | 2 | 7 | 5.1 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)C[C@@H]3CNC(=O)NC)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | |||
CHEMBL446502 | 178361 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 603 | 8 | 2 | 7 | 5.1 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)C[C@@H]3CNC(=O)NC)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | |||
24785703 | 186131 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 534 | 6 | 0 | 5 | 6.5 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2ccc(C)cc2F)c1 | 10.1016/j.bmcl.2008.06.057 | |||
CHEMBL473664 | 186131 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 534 | 6 | 0 | 5 | 6.5 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2ccc(C)cc2F)c1 | 10.1016/j.bmcl.2008.06.057 | |||
122077 | 9102 | 51 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 411 | 5 | 2 | 5 | 4.8 | OC(=O)Cn1c(cc2c1cccc2)C(=O)Nc1scc(n1)c1ccccc1Cl | 10.1016/j.bmcl.2007.09.093 | |||
890 | 9102 | 51 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 411 | 5 | 2 | 5 | 4.8 | OC(=O)Cn1c(cc2c1cccc2)C(=O)Nc1scc(n1)c1ccccc1Cl | 10.1016/j.bmcl.2007.09.093 | |||
CHEMBL249973 | 9102 | 51 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 411 | 5 | 2 | 5 | 4.8 | OC(=O)Cn1c(cc2c1cccc2)C(=O)Nc1scc(n1)c1ccccc1Cl | 10.1016/j.bmcl.2007.09.093 | |||
DB04867 | 9102 | 51 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 411 | 5 | 2 | 5 | 4.8 | OC(=O)Cn1c(cc2c1cccc2)C(=O)Nc1scc(n1)c1ccccc1Cl | 10.1016/j.bmcl.2007.09.093 | |||
44578727 | 196529 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 521 | 6 | 0 | 6 | 5.6 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccccc2F)c1 | 10.1016/j.bmcl.2008.06.057 | |||
CHEMBL515887 | 196529 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 521 | 6 | 0 | 6 | 5.6 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccccc2F)c1 | 10.1016/j.bmcl.2008.06.057 | |||
10008654 | 134394 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 595 | 6 | 3 | 5 | 5.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3cccc4ccccc34)C(=O)C[C@@H]12 | 10.1021/jm0501127 | |||
CHEMBL366344 | 134394 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 595 | 6 | 3 | 5 | 5.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3cccc4ccccc34)C(=O)C[C@@H]12 | 10.1021/jm0501127 | |||
10008654 | 134394 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 595 | 6 | 3 | 5 | 5.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3cccc4ccccc34)C(=O)C[C@@H]12 | 10.1021/jm010813d | |||
CHEMBL366344 | 134394 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 595 | 6 | 3 | 5 | 5.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3cccc4ccccc34)C(=O)C[C@@H]12 | 10.1021/jm010813d | |||
CHEMBL438773 | 220576 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00100a033 | |||||
10482714 | 85206 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 551 | 6 | 3 | 5 | 4.2 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(C3CCCCC3)C(=O)C[C@@H]12 | 10.1021/jm010813d | |||
CHEMBL2111545 | 85206 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 551 | 6 | 3 | 5 | 4.2 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(C3CCCCC3)C(=O)C[C@@H]12 | 10.1021/jm010813d | |||
CHEMBL2370122 | 216566 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | None | None | None | CSCC[C@@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00107a037 | |||||
44578686 | 186152 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 521 | 6 | 0 | 6 | 5.6 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(F)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
CHEMBL473865 | 186152 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 521 | 6 | 0 | 6 | 5.6 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(F)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
CHEMBL267849 | 217513 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00099a005 | |||||
14208225 | 74528 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 426 | 3 | 2 | 3 | 3.9 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00047a021 | |||
CHEMBL1907855 | 74528 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 426 | 3 | 2 | 3 | 3.9 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00047a021 | |||
155535249 | 178782 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 1808 | 68 | 16 | 23 | 2.0 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL4471373 | 178782 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 1808 | 68 | 16 | 23 | 2.0 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
4627 | 7609 | 50 | None | -2 | 5 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9601664 | |||||
864 | 7609 | 50 | None | -2 | 5 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9601664 | |||||
9833444 | 7609 | 50 | None | -2 | 5 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9601664 | |||||
CHEMBL1121 | 7609 | 50 | None | -2 | 5 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9601664 | |||||
DB09142 | 7609 | 50 | None | -2 | 5 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9601664 | |||||
4627 | 7609 | 50 | None | -2 | 5 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm950626d | |||||
864 | 7609 | 50 | None | -2 | 5 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm950626d | |||||
9833444 | 7609 | 50 | None | -2 | 5 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm950626d | |||||
CHEMBL1121 | 7609 | 50 | None | -2 | 5 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm950626d | |||||
DB09142 | 7609 | 50 | None | -2 | 5 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm950626d | |||||
15667014 | 114035 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 976 | 28 | 10 | 11 | 1.5 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00094a001 | |||
CHEMBL316944 | 114035 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 976 | 28 | 10 | 11 | 1.5 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00094a001 | |||
132916 | 9935 | 16 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 438 | 3 | 2 | 3 | 3.8 | O=C(c1cc2c([nH]1)cccc2)N[C@H]1N=C(c2ccccc2F)c2c3N(C1=O)CCc3ccc2 | 10.1016/S0960-894X(96)00609-9 | |||
874 | 9935 | 16 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 438 | 3 | 2 | 3 | 3.8 | O=C(c1cc2c([nH]1)cccc2)N[C@H]1N=C(c2ccccc2F)c2c3N(C1=O)CCc3ccc2 | 10.1016/S0960-894X(96)00609-9 | |||
CHEMBL300072 | 9935 | 16 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 438 | 3 | 2 | 3 | 3.8 | O=C(c1cc2c([nH]1)cccc2)N[C@H]1N=C(c2ccccc2F)c2c3N(C1=O)CCc3ccc2 | 10.1016/S0960-894X(96)00609-9 | |||
443375 | 214385 | 45 | None | -3 | 5 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1016/0960-894X(96)00160-6 | |||
CHEMBL9506 | 214385 | 45 | None | -3 | 5 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1016/0960-894X(96)00160-6 | |||
443375 | 214385 | 45 | None | -3 | 5 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm991078x | |||
CHEMBL9506 | 214385 | 45 | None | -3 | 5 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm991078x | |||
443375 | 214385 | 45 | None | -3 | 5 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm000959x | |||
CHEMBL9506 | 214385 | 45 | None | -3 | 5 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm000959x | |||
44562313 | 179237 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 624 | 9 | 1 | 8 | 4.7 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)C[C@H]3CNS(C)(=O)=O)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | |||
CHEMBL448118 | 179237 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 624 | 9 | 1 | 8 | 4.7 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)C[C@H]3CNS(C)(=O)=O)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.07.083 | |||
14208303 | 211470 | 1 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 513 | 3 | 1 | 3 | 4.0 | CN1C(=O)C(NC(=O)c2cccc(I)c2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL73946 | 211470 | 1 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 513 | 3 | 1 | 3 | 4.0 | CN1C(=O)C(NC(=O)c2cccc(I)c2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
14208303 | 211470 | 1 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 513 | 3 | 1 | 3 | 4.0 | CN1C(=O)C(NC(=O)c2cccc(I)c2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00047a021 | |||
CHEMBL73946 | 211470 | 1 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 513 | 3 | 1 | 3 | 4.0 | CN1C(=O)C(NC(=O)c2cccc(I)c2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00047a021 | |||
15666988 | 114036 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 976 | 29 | 10 | 11 | 1.6 | CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00094a001 | |||
CHEMBL316949 | 114036 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 976 | 29 | 10 | 11 | 1.6 | CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00094a001 | |||
15666988 | 114036 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 976 | 29 | 10 | 11 | 1.6 | CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00031a013 | |||
CHEMBL316949 | 114036 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 976 | 29 | 10 | 11 | 1.6 | CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00031a013 | |||
3476 | 8182 | 9 | None | - | 3 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 | 10.1021/jm00047a021 | |||
59751 | 8182 | 9 | None | - | 3 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 | 10.1021/jm00047a021 | |||
878 | 8182 | 9 | None | - | 3 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 | 10.1021/jm00047a021 | |||
CHEMBL39263 | 8182 | 9 | None | - | 3 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 | 10.1021/jm00047a021 | |||
14208294 | 211014 | 1 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 465 | 3 | 1 | 3 | 4.2 | CN1C(=O)C(NC(=O)c2ccc(Br)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00047a021 | |||
CHEMBL70984 | 211014 | 1 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 465 | 3 | 1 | 3 | 4.2 | CN1C(=O)C(NC(=O)c2ccc(Br)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00047a021 | |||
14208296 | 211408 | 1 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 513 | 3 | 1 | 3 | 4.0 | CN1C(=O)C(NC(=O)c2ccc(I)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00047a021 | |||
CHEMBL73483 | 211408 | 1 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 513 | 3 | 1 | 3 | 4.0 | CN1C(=O)C(NC(=O)c2ccc(I)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00047a021 | |||
155532425 | 178527 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 1822 | 71 | 18 | 23 | 2.5 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)[C@@H](C)CC | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL4467338 | 178527 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 1822 | 71 | 18 | 23 | 2.5 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)[C@@H](C)CC | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL1172428 | 215365 | 0 | None | - | 3 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/j.bmcl.2010.05.078 | |||||
4627 | 7609 | 50 | None | -1 | 5 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | None | None | None | None | 10.1016/s0960-894x(98)00548-4 | |||||
864 | 7609 | 50 | None | -1 | 5 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | None | None | None | None | 10.1016/s0960-894x(98)00548-4 | |||||
9833444 | 7609 | 50 | None | -1 | 5 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | None | None | None | None | 10.1016/s0960-894x(98)00548-4 | |||||
CHEMBL1121 | 7609 | 50 | None | -1 | 5 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | None | None | None | None | 10.1016/s0960-894x(98)00548-4 | |||||
DB09142 | 7609 | 50 | None | -1 | 5 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | None | None | None | None | 10.1016/s0960-894x(98)00548-4 | |||||
3476 | 8182 | 9 | None | - | 3 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 | 10.1021/jm00120a002 | |||
59751 | 8182 | 9 | None | - | 3 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 | 10.1021/jm00120a002 | |||
878 | 8182 | 9 | None | - | 3 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 | 10.1021/jm00120a002 | |||
CHEMBL39263 | 8182 | 9 | None | - | 3 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 | 10.1021/jm00120a002 | |||
14208297 | 74520 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 513 | 3 | 1 | 3 | 4.0 | CN1C(=O)[C@@H](NC(=O)c2ccc(I)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL1907848 | 74520 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 513 | 3 | 1 | 3 | 4.0 | CN1C(=O)[C@@H](NC(=O)c2ccc(I)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
14208295 | 74523 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 465 | 3 | 1 | 3 | 4.2 | CN1C(=O)[C@@H](NC(=O)c2ccc(Br)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL1907850 | 74523 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 465 | 3 | 1 | 3 | 4.2 | CN1C(=O)[C@@H](NC(=O)c2ccc(Br)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
46235271 | 80423 | 2 | None | 2 | 2 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 649 | 7 | 1 | 6 | 6.7 | Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1021/acs.jmedchem.5b01110 | |||
CHEMBL2017835 | 80423 | 2 | None | 2 | 2 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 649 | 7 | 1 | 6 | 6.7 | Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1021/acs.jmedchem.5b01110 | |||
14208268 | 211263 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 418 | 3 | 2 | 4 | 3.5 | CN1C(=O)C(NC(=O)c2ccc(Cl)cc2N)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00047a021 | |||
CHEMBL72428 | 211263 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 418 | 3 | 2 | 4 | 3.5 | CN1C(=O)C(NC(=O)c2ccc(Cl)cc2N)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00047a021 | |||
13822922 | 195859 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 436 | 3 | 2 | 5 | 4.2 | O=C(NC1N=C(c2ccccc2F)c2ccccc2-n2cnnc21)c1cc2ccccc2[nH]1 | 10.1021/jm00396a028 | |||
CHEMBL50986 | 195859 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 436 | 3 | 2 | 5 | 4.2 | O=C(NC1N=C(c2ccccc2F)c2ccccc2-n2cnnc21)c1cc2ccccc2[nH]1 | 10.1021/jm00396a028 | |||
11757476 | 8845 | 1 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 558 | 7 | 4 | 4 | 3.7 | O=C(NC(C)(C)C)N[C@H](C(=O)N[C@@H]1CCCN2[C@H]1CC(=O)N(C2=O)Cc1ccccc1)Cc1c[nH]c2c1cccc2 | 10.1021/jm991078x | |||
876 | 8845 | 1 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 558 | 7 | 4 | 4 | 3.7 | O=C(NC(C)(C)C)N[C@H](C(=O)N[C@@H]1CCCN2[C@H]1CC(=O)N(C2=O)Cc1ccccc1)Cc1c[nH]c2c1cccc2 | 10.1021/jm991078x | |||
CHEMBL2112828 | 8845 | 1 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 558 | 7 | 4 | 4 | 3.7 | O=C(NC(C)(C)C)N[C@H](C(=O)N[C@@H]1CCCN2[C@H]1CC(=O)N(C2=O)Cc1ccccc1)Cc1c[nH]c2c1cccc2 | 10.1021/jm991078x | |||
CHEMBL384035 | 219095 | 4 | None | -8 | 4 | Guinea pig | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00031a013 | |||||
CHEMBL428666 | 219095 | 4 | None | -8 | 4 | Guinea pig | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00031a013 | |||||
155526914 | 177981 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 1837 | 72 | 19 | 24 | 0.8 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL4459331 | 177981 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 1837 | 72 | 19 | 24 | 0.8 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
11017163 | 86320 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 559 | 6 | 3 | 5 | 4.4 | Cc1ccccc1N1C(=O)C[C@H]2[C@H](NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)OC(C)(C)C)CCCN2C1=O | 10.1021/jm010813d | |||
CHEMBL2114081 | 86320 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 559 | 6 | 3 | 5 | 4.4 | Cc1ccccc1N1C(=O)C[C@H]2[C@H](NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)OC(C)(C)C)CCCN2C1=O | 10.1021/jm010813d | |||
15667011 | 103432 | 1 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 990 | 29 | 9 | 11 | 2.0 | CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00094a001 | |||
CHEMBL263742 | 103432 | 1 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 990 | 29 | 9 | 11 | 2.0 | CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00094a001 | |||
15667011 | 103432 | 1 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 990 | 29 | 9 | 11 | 2.0 | CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00031a013 | |||
CHEMBL263742 | 103432 | 1 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 990 | 29 | 9 | 11 | 2.0 | CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00031a013 | |||
196641 | 211177 | 12 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 447 | 3 | 1 | 3 | 4.0 | CN1C(=O)C(NC(=O)c2ccc(Br)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00047a021 | |||
CHEMBL71950 | 211177 | 12 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 447 | 3 | 1 | 3 | 4.0 | CN1C(=O)C(NC(=O)c2ccc(Br)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00047a021 | |||
4627 | 7609 | 50 | None | -1 | 5 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | None | None | None | None | 10.1016/s0960-894x(00)00198-0 | |||||
864 | 7609 | 50 | None | -1 | 5 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | None | None | None | None | 10.1016/s0960-894x(00)00198-0 | |||||
9833444 | 7609 | 50 | None | -1 | 5 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | None | None | None | None | 10.1016/s0960-894x(00)00198-0 | |||||
CHEMBL1121 | 7609 | 50 | None | -1 | 5 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | None | None | None | None | 10.1016/s0960-894x(00)00198-0 | |||||
DB09142 | 7609 | 50 | None | -1 | 5 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | None | None | None | None | 10.1016/s0960-894x(00)00198-0 | |||||
44469677 | 21945 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 336 | 4 | 1 | 4 | 5.4 | C/C(=N\OC(=O)Nc1ccccc1)c1cccc(-c2cccs2)c1 | 10.1016/j.bmcl.2010.06.050 | |||
CHEMBL1210154 | 21945 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 336 | 4 | 1 | 4 | 5.4 | C/C(=N\OC(=O)Nc1ccccc1)c1cccc(-c2cccs2)c1 | 10.1016/j.bmcl.2010.06.050 | |||
196641 | 211177 | 12 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 447 | 3 | 1 | 3 | 4.0 | CN1C(=O)C(NC(=O)c2ccc(Br)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL71950 | 211177 | 12 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 447 | 3 | 1 | 3 | 4.0 | CN1C(=O)C(NC(=O)c2ccc(Br)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
16755782 | 186130 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 538 | 6 | 0 | 5 | 6.3 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2ccc(F)cc2F)c1 | 10.1016/j.bmcl.2008.06.057 | |||
CHEMBL473663 | 186130 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 538 | 6 | 0 | 5 | 6.3 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2ccc(F)cc2F)c1 | 10.1016/j.bmcl.2008.06.057 | |||
44329487 | 115290 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 544 | 6 | 3 | 3 | 5.7 | Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)C[C@H](c3cccc(F)c3)N(CC(=O)NC(C)(C)C)C2=O)c1 | 10.1016/S0960-894X(01)80832-5 | |||
CHEMBL319986 | 115290 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 544 | 6 | 3 | 3 | 5.7 | Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)C[C@H](c3cccc(F)c3)N(CC(=O)NC(C)(C)C)C2=O)c1 | 10.1016/S0960-894X(01)80832-5 | |||
155564421 | 182047 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 1770 | 69 | 16 | 21 | 3.7 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL4572516 | 182047 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 1770 | 69 | 16 | 21 | 3.7 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
4627 | 7609 | 50 | None | -1 | 5 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | None | None | None | None | 10.1021/jm991078x | |||||
864 | 7609 | 50 | None | -1 | 5 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | None | None | None | None | 10.1021/jm991078x | |||||
9833444 | 7609 | 50 | None | -1 | 5 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | None | None | None | None | 10.1021/jm991078x | |||||
CHEMBL1121 | 7609 | 50 | None | -1 | 5 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | None | None | None | None | 10.1021/jm991078x | |||||
DB09142 | 7609 | 50 | None | -1 | 5 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | None | None | None | None | 10.1021/jm991078x | |||||
4627 | 7609 | 50 | None | -1 | 5 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | None | None | None | None | 10.1021/jm0498755 | |||||
864 | 7609 | 50 | None | -1 | 5 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | None | None | None | None | 10.1021/jm0498755 | |||||
9833444 | 7609 | 50 | None | -1 | 5 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | None | None | None | None | 10.1021/jm0498755 | |||||
CHEMBL1121 | 7609 | 50 | None | -1 | 5 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | None | None | None | None | 10.1021/jm0498755 | |||||
DB09142 | 7609 | 50 | None | -1 | 5 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | None | None | None | None | 10.1021/jm0498755 | |||||
4627 | 7609 | 50 | None | -1 | 5 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | None | None | None | None | 10.1021/jm010898i | |||||
864 | 7609 | 50 | None | -1 | 5 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | None | None | None | None | 10.1021/jm010898i | |||||
9833444 | 7609 | 50 | None | -1 | 5 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | None | None | None | None | 10.1021/jm010898i | |||||
CHEMBL1121 | 7609 | 50 | None | -1 | 5 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | None | None | None | None | 10.1021/jm010898i | |||||
DB09142 | 7609 | 50 | None | -1 | 5 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | None | None | None | None | 10.1021/jm010898i | |||||
444998 | 216098 | 30 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm010813d | |||||
CHEMBL216166 | 216098 | 30 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm010813d | |||||
4627 | 7609 | 50 | None | -1 | 5 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(97)00107-8 | |||||
864 | 7609 | 50 | None | -1 | 5 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(97)00107-8 | |||||
9833444 | 7609 | 50 | None | -1 | 5 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(97)00107-8 | |||||
CHEMBL1121 | 7609 | 50 | None | -1 | 5 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(97)00107-8 | |||||
DB09142 | 7609 | 50 | None | -1 | 5 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(97)00107-8 | |||||
10033396 | 115366 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 824 | 20 | 8 | 7 | 3.5 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00028a015 | |||
CHEMBL320405 | 115366 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 824 | 20 | 8 | 7 | 3.5 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00028a015 | |||
44329323 | 114120 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 574 | 7 | 3 | 3 | 6.9 | Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)Nc3ccccc3C)C2=O)c1 | 10.1016/S0960-894X(01)80832-5 | |||
CHEMBL317615 | 114120 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 574 | 7 | 3 | 3 | 6.9 | Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)Nc3ccccc3C)C2=O)c1 | 10.1016/S0960-894X(01)80832-5 | |||
44329331 | 114842 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 540 | 6 | 3 | 3 | 5.9 | Cc1ccc([C@H]2C[C@@H](NC(=O)Nc3cccc(C)c3)C(=O)N(CC(=O)NC(C)(C)C)[C@@H](c3ccccc3)C2)cc1 | 10.1016/S0960-894X(01)80832-5 | |||
CHEMBL319504 | 114842 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 540 | 6 | 3 | 3 | 5.9 | Cc1ccc([C@H]2C[C@@H](NC(=O)Nc3cccc(C)c3)C(=O)N(CC(=O)NC(C)(C)C)[C@@H](c3ccccc3)C2)cc1 | 10.1016/S0960-894X(01)80832-5 | |||
44329363 | 115481 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 594 | 7 | 3 | 3 | 7.2 | Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)Nc3ccccc3Cl)C2=O)c1 | 10.1016/S0960-894X(01)80832-5 | |||
CHEMBL320821 | 115481 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 594 | 7 | 3 | 3 | 7.2 | Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)Nc3ccccc3Cl)C2=O)c1 | 10.1016/S0960-894X(01)80832-5 | |||
11027990 | 74306 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 545 | 6 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm010813d | |||
CHEMBL189634 | 74306 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 545 | 6 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm010813d | |||
44269000 | 39690 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 671 | 14 | 6 | 5 | 6.3 | Cc1ccccc1NC(=O)NCCCC[C@@H](CC(=O)O)NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 | 10.1016/s0960-894x(00)00198-0 | |||
CHEMBL14153 | 39690 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 671 | 14 | 6 | 5 | 6.3 | Cc1ccccc1NC(=O)NCCCC[C@@H](CC(=O)O)NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 | 10.1016/s0960-894x(00)00198-0 | |||
44269000 | 39690 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 671 | 14 | 6 | 5 | 6.3 | Cc1ccccc1NC(=O)NCCCC[C@@H](CC(=O)O)NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 | 10.1016/s0960-894x(01)00630-8 | |||
CHEMBL14153 | 39690 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 671 | 14 | 6 | 5 | 6.3 | Cc1ccccc1NC(=O)NCCCC[C@@H](CC(=O)O)NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 | 10.1016/s0960-894x(01)00630-8 | |||
155533399 | 178624 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 1838 | 72 | 19 | 24 | 1.4 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL4468861 | 178624 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 1838 | 72 | 19 | 24 | 1.4 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
4627 | 7609 | 50 | None | -2 | 5 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(97)00062-0 | |||||
864 | 7609 | 50 | None | -2 | 5 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(97)00062-0 | |||||
9833444 | 7609 | 50 | None | -2 | 5 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(97)00062-0 | |||||
CHEMBL1121 | 7609 | 50 | None | -2 | 5 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(97)00062-0 | |||||
DB09142 | 7609 | 50 | None | -2 | 5 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(97)00062-0 | |||||
14208311 | 211443 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 437 | 3 | 1 | 3 | 4.3 | CN1C(=O)C(NC(=O)c2ccc(C(F)(F)F)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00047a021 | |||
CHEMBL73699 | 211443 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 437 | 3 | 1 | 3 | 4.3 | CN1C(=O)C(NC(=O)c2ccc(C(F)(F)F)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00047a021 | |||
14208227 | 109041 | 1 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 440 | 3 | 1 | 4 | 3.9 | CN1C(=O)C(NC(=O)c2cc3ccccc3n2C)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL303227 | 109041 | 1 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 440 | 3 | 1 | 4 | 3.9 | CN1C(=O)C(NC(=O)c2cc3ccccc3n2C)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
14208312 | 84597 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 437 | 3 | 1 | 3 | 4.3 | CN1C(=O)[C@@H](NC(=O)c2ccc(C(F)(F)F)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL2092865 | 84597 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 437 | 3 | 1 | 3 | 4.3 | CN1C(=O)[C@@H](NC(=O)c2ccc(C(F)(F)F)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
10373344 | 173413 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 844 | 21 | 8 | 7 | 3.8 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00028a015 | |||
CHEMBL428103 | 173413 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 844 | 21 | 8 | 7 | 3.8 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00028a015 | |||
10341724 | 85290 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 414 | 4 | 2 | 4 | 3.7 | COc1cccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00078a018 | |||
CHEMBL2111922 | 85290 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 414 | 4 | 2 | 4 | 3.7 | COc1cccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00078a018 | |||
24861174 | 181386 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 546 | 6 | 1 | 6 | 5.7 | COc1cccc(-n2cc(C(=O)N3CCN(c4cc5ccccc5cc4C(=O)O)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
CHEMBL455742 | 181386 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 546 | 6 | 1 | 6 | 5.7 | COc1cccc(-n2cc(C(=O)N3CCN(c4cc5ccccc5cc4C(=O)O)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
44578424 | 189705 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 503 | 5 | 0 | 6 | 5.4 | COc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
CHEMBL479256 | 189705 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 503 | 5 | 0 | 6 | 5.4 | COc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
44329286 | 113982 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 540 | 6 | 3 | 3 | 5.9 | Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3cccc(C)c3)C[C@H](c3ccccc3)N(CC(=O)NC(C)(C)C)C2=O)c1 | 10.1016/S0960-894X(01)80832-5 | |||
CHEMBL316619 | 113982 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 540 | 6 | 3 | 3 | 5.9 | Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3cccc(C)c3)C[C@H](c3ccccc3)N(CC(=O)NC(C)(C)C)C2=O)c1 | 10.1016/S0960-894X(01)80832-5 | |||
4627 | 7609 | 50 | None | -2 | 5 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm960249k | |||||
864 | 7609 | 50 | None | -2 | 5 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm960249k | |||||
9833444 | 7609 | 50 | None | -2 | 5 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm960249k | |||||
CHEMBL1121 | 7609 | 50 | None | -2 | 5 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm960249k | |||||
DB09142 | 7609 | 50 | None | -2 | 5 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm960249k | |||||
4627 | 7609 | 50 | None | -2 | 5 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm960205b | |||||
864 | 7609 | 50 | None | -2 | 5 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm960205b | |||||
9833444 | 7609 | 50 | None | -2 | 5 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm960205b | |||||
CHEMBL1121 | 7609 | 50 | None | -2 | 5 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm960205b | |||||
DB09142 | 7609 | 50 | None | -2 | 5 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm960205b | |||||
4627 | 7609 | 50 | None | -2 | 5 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm970265x | |||||
864 | 7609 | 50 | None | -2 | 5 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm970265x | |||||
9833444 | 7609 | 50 | None | -2 | 5 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm970265x | |||||
CHEMBL1121 | 7609 | 50 | None | -2 | 5 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm970265x | |||||
DB09142 | 7609 | 50 | None | -2 | 5 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm970265x | |||||
11082524 | 122231 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 591 | 7 | 3 | 5 | 5.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=S)N(Cc3ccccc3)C(=S)C[C@@H]12 | 10.1021/jm010898i | |||
CHEMBL3350853 | 122231 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 591 | 7 | 3 | 5 | 5.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=S)N(Cc3ccccc3)C(=S)C[C@@H]12 | 10.1021/jm010898i | |||
14208227 | 109041 | 1 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 440 | 3 | 1 | 4 | 3.9 | CN1C(=O)C(NC(=O)c2cc3ccccc3n2C)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00047a021 | |||
CHEMBL303227 | 109041 | 1 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 440 | 3 | 1 | 4 | 3.9 | CN1C(=O)C(NC(=O)c2cc3ccccc3n2C)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00047a021 | |||
CHEMBL411202 | 219652 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00100a033 | |||||
54580295 | 68687 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 519 | 5 | 0 | 6 | 5.5 | COc1ccc(-c2cnc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccccc2F)cc1 | 10.1016/j.bmcl.2011.03.069 | |||
CHEMBL1774032 | 68687 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 519 | 5 | 0 | 6 | 5.5 | COc1ccc(-c2cnc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccccc2F)cc1 | 10.1016/j.bmcl.2011.03.069 | |||
14208232 | 210918 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 452 | 5 | 3 | 4 | 3.2 | O=C(O)CN1C(=O)C(NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL70456 | 210918 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 452 | 5 | 3 | 4 | 3.2 | O=C(O)CN1C(=O)C(NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
14208231 | 211025 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 422 | 3 | 1 | 4 | 3.7 | CN1C(=O)C(NC(=O)c2cc3ccccc3n2C)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL71079 | 211025 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 422 | 3 | 1 | 4 | 3.7 | CN1C(=O)C(NC(=O)c2cc3ccccc3n2C)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
10093957 | 211413 | 1 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 426 | 3 | 2 | 3 | 3.9 | CN1C(=O)C(NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL73522 | 211413 | 1 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 426 | 3 | 2 | 3 | 3.9 | CN1C(=O)C(NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
10350551 | 115232 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 838 | 21 | 8 | 7 | 3.9 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00028a015 | |||
CHEMBL319913 | 115232 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 838 | 21 | 8 | 7 | 3.9 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00028a015 | |||
14208231 | 211025 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 422 | 3 | 1 | 4 | 3.7 | CN1C(=O)C(NC(=O)c2cc3ccccc3n2C)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(00)80682-4 | |||
CHEMBL71079 | 211025 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 422 | 3 | 1 | 4 | 3.7 | CN1C(=O)C(NC(=O)c2cc3ccccc3n2C)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(00)80682-4 | |||
14208231 | 211025 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 422 | 3 | 1 | 4 | 3.7 | CN1C(=O)C(NC(=O)c2cc3ccccc3n2C)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00047a021 | |||
CHEMBL71079 | 211025 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 422 | 3 | 1 | 4 | 3.7 | CN1C(=O)C(NC(=O)c2cc3ccccc3n2C)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00047a021 | |||
10093957 | 211413 | 1 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 426 | 3 | 2 | 3 | 3.9 | CN1C(=O)C(NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00047a021 | |||
CHEMBL73522 | 211413 | 1 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 426 | 3 | 2 | 3 | 3.9 | CN1C(=O)C(NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00047a021 | |||
46235271 | 80423 | 2 | None | 2 | 2 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 649 | 7 | 1 | 6 | 6.7 | Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1021/acs.jmedchem.5b01110 | |||
CHEMBL2017835 | 80423 | 2 | None | 2 | 2 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 649 | 7 | 1 | 6 | 6.7 | Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1021/acs.jmedchem.5b01110 | |||
14208228 | 109884 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 470 | 5 | 3 | 4 | 3.3 | O=C(O)CN1C(=O)C(NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL307661 | 109884 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 470 | 5 | 3 | 4 | 3.3 | O=C(O)CN1C(=O)C(NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL1172429 | 215366 | 0 | None | 26 | 4 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/j.bmcl.2010.05.078 | |||||
5311188 | 16577 | 2 | None | -1 | 2 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 559 | 7 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm991078x | |||
CHEMBL113718 | 16577 | 2 | None | -1 | 2 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 559 | 7 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm991078x | |||
5311188 | 16577 | 2 | None | -1 | 2 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 559 | 7 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm0501127 | |||
CHEMBL113718 | 16577 | 2 | None | -1 | 2 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 559 | 7 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm0501127 | |||
44396619 | 173024 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 516 | 7 | 2 | 5 | 4.4 | CC(C)(C)OC(=O)[C@H](Cc1c[nH]c2ccccc12)N[C@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)CC12 | 10.1021/jm0498755 | |||
CHEMBL426792 | 173024 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 516 | 7 | 2 | 5 | 4.4 | CC(C)(C)OC(=O)[C@H](Cc1c[nH]c2ccccc12)N[C@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)CC12 | 10.1021/jm0498755 | |||
5311188 | 16577 | 2 | None | -1 | 2 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 559 | 7 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm010898i | |||
CHEMBL113718 | 16577 | 2 | None | -1 | 2 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 559 | 7 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm010898i | |||
5311188 | 16577 | 2 | None | -1 | 2 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 559 | 7 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm010813d | |||
CHEMBL113718 | 16577 | 2 | None | -1 | 2 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 559 | 7 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm010813d | |||
CHEMBL107694 | 215269 | 0 | None | - | 0 | Guinea pig | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | None | None | None | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00028a015 | |||||
44329330 | 113964 | 0 | None | - | 0 | Guinea pig | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 540 | 6 | 3 | 3 | 5.9 | Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)C[C@H](c3cccc(C)c3)N(CC(=O)NC(C)(C)C)C2=O)c1 | 10.1016/S0960-894X(01)80832-5 | |||
CHEMBL316504 | 113964 | 0 | None | - | 0 | Guinea pig | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 540 | 6 | 3 | 3 | 5.9 | Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)C[C@H](c3cccc(C)c3)N(CC(=O)NC(C)(C)C)C2=O)c1 | 10.1016/S0960-894X(01)80832-5 | |||
10076650 | 33004 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 566 | 8 | 4 | 5 | 3.5 | O=C(N[C@@H]1C[C@H]2c3[nH]c4ccccc4c3C[C@H](C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N2C1=O)OCc1ccccc1 | 10.1021/jm050689o | |||
CHEMBL13577 | 33004 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 566 | 8 | 4 | 5 | 3.5 | O=C(N[C@@H]1C[C@H]2c3[nH]c4ccccc4c3C[C@H](C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N2C1=O)OCc1ccccc1 | 10.1021/jm050689o | |||
10010723 | 11685 | 0 | None | - | 0 | Guinea pig | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 836 | 20 | 8 | 7 | 3.1 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C(F)(F)F)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00028a015 | |||
CHEMBL104598 | 11685 | 0 | None | - | 0 | Guinea pig | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 836 | 20 | 8 | 7 | 3.1 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C(F)(F)F)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00028a015 | |||
108187 | 7713 | 37 | None | 4 | 5 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1021/jm00086a017 | |||
873 | 7713 | 37 | None | 4 | 5 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1021/jm00086a017 | |||
CHEMBL2062154 | 7713 | 37 | None | 4 | 5 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1021/jm00086a017 | |||
CHEMBL287735 | 7713 | 37 | None | 4 | 5 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1021/jm00086a017 | |||
10076650 | 33004 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 566 | 8 | 4 | 5 | 3.5 | O=C(N[C@@H]1C[C@H]2c3[nH]c4ccccc4c3C[C@H](C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N2C1=O)OCc1ccccc1 | 10.1016/s0960-894x(01)00630-8 | |||
CHEMBL13577 | 33004 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 566 | 8 | 4 | 5 | 3.5 | O=C(N[C@@H]1C[C@H]2c3[nH]c4ccccc4c3C[C@H](C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N2C1=O)OCc1ccccc1 | 10.1016/s0960-894x(01)00630-8 | |||
10076650 | 33004 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 566 | 8 | 4 | 5 | 3.5 | O=C(N[C@@H]1C[C@H]2c3[nH]c4ccccc4c3C[C@H](C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N2C1=O)OCc1ccccc1 | 10.1021/jm000959x | |||
CHEMBL13577 | 33004 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 566 | 8 | 4 | 5 | 3.5 | O=C(N[C@@H]1C[C@H]2c3[nH]c4ccccc4c3C[C@H](C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N2C1=O)OCc1ccccc1 | 10.1021/jm000959x | |||
44329352 | 118214 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 544 | 6 | 3 | 3 | 5.7 | Cc1ccccc1[C@H]1C[C@@H](NC(=O)Nc2cccc(F)c2)C(=O)N(CC(=O)NC(C)(C)C)[C@@H](c2ccccc2)C1 | 10.1016/S0960-894X(01)80832-5 | |||
CHEMBL327496 | 118214 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 544 | 6 | 3 | 3 | 5.7 | Cc1ccccc1[C@H]1C[C@@H](NC(=O)Nc2cccc(F)c2)C(=O)N(CC(=O)NC(C)(C)C)[C@@H](c2ccccc2)C1 | 10.1016/S0960-894X(01)80832-5 | |||
44578647 | 186107 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 538 | 6 | 0 | 5 | 6.3 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2c(F)cccc2F)c1 | 10.1016/j.bmcl.2008.06.057 | |||
CHEMBL473457 | 186107 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 538 | 6 | 0 | 5 | 6.3 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2c(F)cccc2F)c1 | 10.1016/j.bmcl.2008.06.057 | |||
24785178 | 188318 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 520 | 6 | 0 | 5 | 6.2 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2ccc(F)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
CHEMBL476530 | 188318 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 520 | 6 | 0 | 5 | 6.2 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2ccc(F)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
44578423 | 196438 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 503 | 5 | 0 | 6 | 5.4 | COc1cccc(-n2cc(C(=O)N3CCN(c4cc5ccccc5cn4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
CHEMBL515161 | 196438 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 503 | 5 | 0 | 6 | 5.4 | COc1cccc(-n2cc(C(=O)N3CCN(c4cc5ccccc5cn4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
24785431 | 196589 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 520 | 6 | 0 | 5 | 6.2 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2ccccc2F)c1 | 10.1016/j.bmcl.2008.06.057 | |||
CHEMBL516355 | 196589 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 520 | 6 | 0 | 5 | 6.2 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2ccccc2F)c1 | 10.1016/j.bmcl.2008.06.057 | |||
52949124 | 7663 | 4 | None | -2 | 2 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
9055 | 7663 | 4 | None | -2 | 2 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
CHEMBL1269258 | 7663 | 4 | None | -2 | 2 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
DB12694 | 7663 | 4 | None | -2 | 2 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
44365788 | 128471 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 643 | 7 | 1 | 7 | 5.5 | COC(=O)n1c(C(=O)NC2C(=O)N(CC(=O)N(c3ccccc3)C(C)C)c3ccccc3N(c3ccccc3)C2=O)cc2ccccc21 | 10.1021/jm9601664 | |||
CHEMBL358778 | 128471 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 643 | 7 | 1 | 7 | 5.5 | COC(=O)n1c(C(=O)NC2C(=O)N(CC(=O)N(c3ccccc3)C(C)C)c3ccccc3N(c3ccccc3)C2=O)cc2ccccc21 | 10.1021/jm9601664 | |||
46235271 | 80423 | 2 | None | 2 | 2 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 649 | 7 | 1 | 6 | 6.7 | Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1021/acs.jmedchem.5b01110 | |||
CHEMBL2017835 | 80423 | 2 | None | 2 | 2 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 649 | 7 | 1 | 6 | 6.7 | Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1021/acs.jmedchem.5b01110 | |||
CHEMBL1172252 | 215363 | 0 | None | -12 | 4 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/j.bmcl.2010.05.078 | |||||
10046672 | 122860 | 2 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 402 | 3 | 2 | 3 | 3.8 | CN1C(=O)C(NC(=O)Nc2cccc(F)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL335666 | 122860 | 2 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 402 | 3 | 2 | 3 | 3.8 | CN1C(=O)C(NC(=O)Nc2cccc(F)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
10364786 | 111648 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 419 | 2 | 2 | 4 | 3.7 | Cc1cccc(NC(=O)NC2N=C(N3CCCCCC3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm9608523 | |||
CHEMBL311061 | 111648 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 419 | 2 | 2 | 4 | 3.7 | Cc1cccc(NC(=O)NC2N=C(N3CCCCCC3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm9608523 | |||
44329383 | 115068 | 0 | None | - | 0 | Guinea pig | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 526 | 6 | 3 | 3 | 5.5 | Cc1cccc(NC(=O)N[C@H]2C[C@H](c3ccccc3)C[C@H](c3ccccc3)N(CC(=O)NC(C)(C)C)C2=O)c1 | 10.1016/S0960-894X(01)80832-5 | |||
CHEMBL319749 | 115068 | 0 | None | - | 0 | Guinea pig | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 526 | 6 | 3 | 3 | 5.5 | Cc1cccc(NC(=O)N[C@H]2C[C@H](c3ccccc3)C[C@H](c3ccccc3)N(CC(=O)NC(C)(C)C)C2=O)c1 | 10.1016/S0960-894X(01)80832-5 | |||
44336539 | 11916 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 563 | 7 | 2 | 5 | 4.6 | COc1ccc(N(C)C(=O)CN2C(=O)C(NC(=O)Nc3ccccc3)C(=O)N(c3ccccc3)c3ccccc32)cc1 | 10.1016/j.bmcl.2015.03.051 | |||
CHEMBL105775 | 11916 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 563 | 7 | 2 | 5 | 4.6 | COc1ccc(N(C)C(=O)CN2C(=O)C(NC(=O)Nc3ccccc3)C(=O)N(c3ccccc3)c3ccccc32)cc1 | 10.1016/j.bmcl.2015.03.051 | |||
10364786 | 111648 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 419 | 2 | 2 | 4 | 3.7 | Cc1cccc(NC(=O)NC2N=C(N3CCCCCC3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00032a002 | |||
CHEMBL311061 | 111648 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 419 | 2 | 2 | 4 | 3.7 | Cc1cccc(NC(=O)NC2N=C(N3CCCCCC3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00032a002 | |||
10627173 | 213321 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 586 | 8 | 1 | 4 | 6.5 | COc1ccc(N(C(=O)CN2C(=O)C(Cc3c[nH]c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm970265x | |||
CHEMBL88602 | 213321 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 586 | 8 | 1 | 4 | 6.5 | COc1ccc(N(C(=O)CN2C(=O)C(Cc3c[nH]c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm970265x | |||
44346576 | 17541 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 399 | 4 | 2 | 3 | 3.8 | O=C(/C=C\c1ccccc1)NC1N=C(c2ccccc2F)c2ccccc2NC1=O | 10.1021/jm00047a021 | |||
CHEMBL117158 | 17541 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 399 | 4 | 2 | 3 | 3.8 | O=C(/C=C\c1ccccc1)NC1N=C(c2ccccc2F)c2ccccc2NC1=O | 10.1021/jm00047a021 | |||
14208272 | 74513 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 455 | 3 | 1 | 3 | 4.4 | CN1C(=O)[C@@H](NC(=O)c2ccc(C(F)(F)F)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00047a021 | |||
CHEMBL1907841 | 74513 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 455 | 3 | 1 | 3 | 4.4 | CN1C(=O)[C@@H](NC(=O)c2ccc(C(F)(F)F)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00047a021 | |||
10627173 | 213321 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 586 | 8 | 1 | 4 | 6.5 | COc1ccc(N(C(=O)CN2C(=O)C(Cc3c[nH]c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm960249k | |||
CHEMBL88602 | 213321 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 586 | 8 | 1 | 4 | 6.5 | COc1ccc(N(C(=O)CN2C(=O)C(Cc3c[nH]c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm960249k | |||
14208230 | 109986 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 446 | 3 | 3 | 3 | 4.5 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1cc2cc(Cl)ccc2[nH]1 | 10.1021/jm00047a021 | |||
CHEMBL308414 | 109986 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 446 | 3 | 3 | 3 | 4.5 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1cc2cc(Cl)ccc2[nH]1 | 10.1021/jm00047a021 | |||
14208274 | 176071 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 443 | 3 | 1 | 3 | 4.7 | CN1C(=O)C(NC(=O)c2ccc(C(C)(C)C)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00047a021 | |||
CHEMBL441445 | 176071 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 443 | 3 | 1 | 3 | 4.7 | CN1C(=O)C(NC(=O)c2ccc(C(C)(C)C)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00047a021 | |||
15689736 | 113377 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 862 | 20 | 9 | 8 | 4.5 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC/N=C(\S)Nc1ccccc1Cl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||
CHEMBL3142702 | 113377 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 862 | 20 | 9 | 8 | 4.5 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC/N=C(\S)Nc1ccccc1Cl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||
11801335 | 126313 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 579 | 7 | 2 | 4 | 5.5 | CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccc(F)cc1 | 10.1021/jm950626d | |||
CHEMBL345786 | 126313 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 579 | 7 | 2 | 4 | 5.5 | CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccc(F)cc1 | 10.1021/jm950626d | |||
44306868 | 108860 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 836 | 18 | 9 | 7 | 3.7 | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NC(Cc1ccc(NC(=O)Nc2ccccc2Cl)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccc(C)cc1)C(N)=O | 10.1021/jm00001a027 | |||
CHEMBL302150 | 108860 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 836 | 18 | 9 | 7 | 3.7 | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NC(Cc1ccc(NC(=O)Nc2ccccc2Cl)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccc(C)cc1)C(N)=O | 10.1021/jm00001a027 | |||
44306888 | 109107 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 816 | 18 | 9 | 7 | 3.4 | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NC(Cc1cccc(NC(=O)Nc2ccccc2C)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccc(C)cc1)C(N)=O | 10.1021/jm00001a027 | |||
CHEMBL303635 | 109107 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 816 | 18 | 9 | 7 | 3.4 | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NC(Cc1cccc(NC(=O)Nc2ccccc2C)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccc(C)cc1)C(N)=O | 10.1021/jm00001a027 | |||
13953709 | 169117 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 409 | 4 | 1 | 6 | 4.0 | O=C(NC1N=C(c2ccccc2)c2ccccc2-n2cnnc21)OCc1ccccc1 | 10.1021/jm00396a028 | |||
CHEMBL416483 | 169117 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 409 | 4 | 1 | 6 | 4.0 | O=C(NC1N=C(c2ccccc2)c2ccccc2-n2cnnc21)OCc1ccccc1 | 10.1021/jm00396a028 | |||
14208274 | 176071 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 443 | 3 | 1 | 3 | 4.7 | CN1C(=O)C(NC(=O)c2ccc(C(C)(C)C)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL441445 | 176071 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 443 | 3 | 1 | 3 | 4.7 | CN1C(=O)C(NC(=O)c2ccc(C(C)(C)C)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
9988264 | 116500 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 888 | 22 | 9 | 8 | 3.5 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00028a015 | |||
CHEMBL322955 | 116500 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 888 | 22 | 9 | 8 | 3.5 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00028a015 | |||
10886229 | 85368 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 559 | 6 | 3 | 5 | 4.4 | Cc1cccc(N2C(=O)C[C@@H]3[C@@H](NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)OC(C)(C)C)CCCN3C2=O)c1 | 10.1021/jm010813d | |||
CHEMBL2112234 | 85368 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 559 | 6 | 3 | 5 | 4.4 | Cc1cccc(N2C(=O)C[C@@H]3[C@@H](NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)OC(C)(C)C)CCCN3C2=O)c1 | 10.1021/jm010813d | |||
44382057 | 127113 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 420 | 4 | 2 | 3 | 3.1 | Cc1cccc(NC(=O)N[C@H]2CCc3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 | 10.1016/S0960-894X(00)80683-6 | |||
CHEMBL352939 | 127113 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 420 | 4 | 2 | 3 | 3.1 | Cc1cccc(NC(=O)N[C@H]2CCc3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 | 10.1016/S0960-894X(00)80683-6 | |||
44301015 | 205840 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 609 | 7 | 5 | 7 | 3.7 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)Nc3nn[nH]n3)c1)C[C@@H]2c1ccccc1 | 10.1016/0960-894X(95)00327-P | |||
CHEMBL58658 | 205840 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 609 | 7 | 5 | 7 | 3.7 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)Nc3nn[nH]n3)c1)C[C@@H]2c1ccccc1 | 10.1016/0960-894X(95)00327-P | |||
10001488 | 171705 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 408 | 4 | 3 | 3 | 3.6 | O=C(Cc1c[nH]c2ccccc12)NC1N=C(c2ccccc2)c2ccccc2NC1=O | 10.1021/jm00047a021 | |||
CHEMBL422411 | 171705 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 408 | 4 | 3 | 3 | 3.6 | O=C(Cc1c[nH]c2ccccc12)NC1N=C(c2ccccc2)c2ccccc2NC1=O | 10.1021/jm00047a021 | |||
CHEMBL2112688 | 216027 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@@H](NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)[C@H](C)c1c[nH]c2ccccc12 | 10.1021/jm960078j | |||||
52949124 | 7663 | 4 | None | -2 | 2 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
9055 | 7663 | 4 | None | -2 | 2 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
CHEMBL1269258 | 7663 | 4 | None | -2 | 2 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
DB12694 | 7663 | 4 | None | -2 | 2 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
46235271 | 80423 | 2 | None | 2 | 2 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 649 | 7 | 1 | 6 | 6.7 | Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1021/acs.jmedchem.5b01110 | |||
CHEMBL2017835 | 80423 | 2 | None | 2 | 2 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 649 | 7 | 1 | 6 | 6.7 | Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1021/acs.jmedchem.5b01110 | |||
46235271 | 80423 | 2 | None | 2 | 2 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 649 | 7 | 1 | 6 | 6.7 | Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1021/acs.jmedchem.5b01110 | |||
CHEMBL2017835 | 80423 | 2 | None | 2 | 2 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 649 | 7 | 1 | 6 | 6.7 | Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1021/acs.jmedchem.5b01110 | |||
10649606 | 56390 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 519 | 6 | 3 | 4 | 4.5 | O=C(CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)Nc1ccccc1 | 10.1016/j.bmcl.2015.03.051 | |||
CHEMBL156605 | 56390 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 519 | 6 | 3 | 4 | 4.5 | O=C(CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)Nc1ccccc1 | 10.1016/j.bmcl.2015.03.051 | |||
10001488 | 171705 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 408 | 4 | 3 | 3 | 3.6 | O=C(Cc1c[nH]c2ccccc12)NC1N=C(c2ccccc2)c2ccccc2NC1=O | 10.1021/jm00120a002 | |||
CHEMBL422411 | 171705 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 408 | 4 | 3 | 3 | 3.6 | O=C(Cc1c[nH]c2ccccc12)NC1N=C(c2ccccc2)c2ccccc2NC1=O | 10.1021/jm00120a002 | |||
14208202 | 211421 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 443 | 4 | 2 | 4 | 4.5 | O=C(Cc1cccc2sccc12)NC1N=C(c2ccccc2F)c2ccccc2NC1=O | 10.1021/jm00120a002 | |||
CHEMBL73563 | 211421 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 443 | 4 | 2 | 4 | 4.5 | O=C(Cc1cccc2sccc12)NC1N=C(c2ccccc2F)c2ccccc2NC1=O | 10.1021/jm00120a002 | |||
44362701 | 127912 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 580 | 9 | 4 | 5 | 3.9 | O=C(O)C[C@@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@@H]2C[C@H](NC(=O)OCc3ccccc3)C(=O)N12 | 10.1016/s0960-894x(98)00677-5 | |||
CHEMBL357576 | 127912 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 580 | 9 | 4 | 5 | 3.9 | O=C(O)C[C@@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@@H]2C[C@H](NC(=O)OCc3ccccc3)C(=O)N12 | 10.1016/s0960-894x(98)00677-5 | |||
44370446 | 126379 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 467 | 15 | 2 | 4 | 5.4 | CCCCCN(CCCCC)C(=O)C(CCC(=O)OCC)NC(=O)Nc1ccc(Cl)cc1 | 10.1021/jm00164a020 | |||
CHEMBL346361 | 126379 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 467 | 15 | 2 | 4 | 5.4 | CCCCCN(CCCCC)C(=O)C(CCC(=O)OCC)NC(=O)Nc1ccc(Cl)cc1 | 10.1021/jm00164a020 | |||
20152922 | 125753 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 440 | 5 | 2 | 3 | 4.3 | CN1c2ccccc2C(c2ccccc2F)=NCC1CNC(=O)Cc1c[nH]c2ccccc12 | 10.1021/jm00163a069 | |||
CHEMBL342415 | 125753 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 440 | 5 | 2 | 3 | 4.3 | CN1c2ccccc2C(c2ccccc2F)=NCC1CNC(=O)Cc1c[nH]c2ccccc12 | 10.1021/jm00163a069 | |||
10414170 | 177397 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 515 | 5 | 2 | 4 | 4.3 | O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N2CCCC2)C1=O | 10.1021/jm00078a018 | |||
CHEMBL445095 | 177397 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 515 | 5 | 2 | 4 | 4.3 | O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N2CCCC2)C1=O | 10.1021/jm00078a018 | |||
15200522 | 127246 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 422 | 4 | 2 | 3 | 3.7 | CN1C(=O)C(NC(=O)Cc2c[nH]c3ccccc23)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(00)80682-4 | |||
CHEMBL354126 | 127246 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 422 | 4 | 2 | 3 | 3.7 | CN1C(=O)C(NC(=O)Cc2c[nH]c3ccccc23)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(00)80682-4 | |||
CHEMBL37983 | 219045 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | None | None | None | CS[C@H]1CCN(C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(C)=O)[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00001a019 | |||||
656755 | 74484 | 32 | None | - | 0 | Guinea pig | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 397 | 3 | 1 | 2 | 4.7 | CN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00390a019 | |||
CHEMBL1907717 | 74484 | 32 | None | - | 0 | Guinea pig | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 397 | 3 | 1 | 2 | 4.7 | CN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00390a019 | |||
15167824 | 74493 | 0 | None | - | 0 | Guinea pig | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 379 | 3 | 1 | 2 | 4.6 | CN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00390a019 | |||
CHEMBL1907731 | 74493 | 0 | None | - | 0 | Guinea pig | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 379 | 3 | 1 | 2 | 4.6 | CN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00390a019 | |||
20190196 | 38562 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 388 | 4 | 1 | 4 | 3.3 | CN1c2ccccc2C(c2ccccc2F)=NCC1CNC(=O)c1cccnc1 | 10.1021/jm00163a069 | |||
CHEMBL140620 | 38562 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 388 | 4 | 1 | 4 | 3.3 | CN1c2ccccc2C(c2ccccc2F)=NCC1CNC(=O)c1cccnc1 | 10.1021/jm00163a069 | |||
15167799 | 125965 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 379 | 4 | 2 | 4 | 3.9 | O=C(NCC1CNc2ccccc2C(c2ccccc2F)=N1)c1ccsc1 | 10.1021/jm00163a069 | |||
CHEMBL343158 | 125965 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 379 | 4 | 2 | 4 | 3.9 | O=C(NCC1CNc2ccccc2C(c2ccccc2F)=N1)c1ccsc1 | 10.1021/jm00163a069 | |||
44381820 | 127402 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 689 | 18 | 7 | 8 | 2.8 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](C#N)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/S0960-894X(97)00107-8 | |||
CHEMBL354631 | 127402 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 689 | 18 | 7 | 8 | 2.8 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](C#N)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/S0960-894X(97)00107-8 | |||
44381821 | 127403 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 689 | 18 | 7 | 8 | 2.8 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@H](C#N)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/S0960-894X(97)00107-8 | |||
CHEMBL354632 | 127403 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 689 | 18 | 7 | 8 | 2.8 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@H](C#N)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/S0960-894X(97)00107-8 | |||
44348835 | 23593 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 938 | 25 | 11 | 11 | 0.2 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00099a005 | |||
CHEMBL124719 | 23593 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 938 | 25 | 11 | 11 | 0.2 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00099a005 | |||
14208262 | 211298 | 0 | None | - | 0 | Rat | 4.0 | pIC50 | = | 4 | Binding | ChEMBL | 431 | 4 | 2 | 3 | 4.9 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccc(-c2ccccc2)cc1 | 10.1021/jm00047a021 | |||
CHEMBL72670 | 211298 | 0 | None | - | 0 | Rat | 4.0 | pIC50 | = | 4 | Binding | ChEMBL | 431 | 4 | 2 | 3 | 4.9 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccc(-c2ccccc2)cc1 | 10.1021/jm00047a021 | |||
7216755 | 66314 | 7 | None | - | 0 | Rat | 4.0 | pIC50 | = | 4 | Binding | ChEMBL | 265 | 1 | 1 | 3 | 1.8 | CN1C(=O)[C@@H](N)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL171651 | 66314 | 7 | None | - | 0 | Rat | 4.0 | pIC50 | = | 4 | Binding | ChEMBL | 265 | 1 | 1 | 3 | 1.8 | CN1C(=O)[C@@H](N)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
44311988 | 109808 | 0 | None | - | 0 | Rat | 4.0 | pIC50 | = | 4 | Binding | ChEMBL | 412 | 5 | 2 | 4 | 2.5 | CN1C(=O)[C@H](NC(=O)[C@H](N)Cc2ccccc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL307034 | 109808 | 0 | None | - | 0 | Rat | 4.0 | pIC50 | = | 4 | Binding | ChEMBL | 412 | 5 | 2 | 4 | 2.5 | CN1C(=O)[C@H](NC(=O)[C@H](N)Cc2ccccc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
14208206 | 170248 | 0 | None | - | 0 | Rat | 4.0 | pIC50 | = | 4 | Binding | ChEMBL | 403 | 4 | 3 | 4 | 2.8 | O=C1Nc2ccccc2C(c2ccccc2F)=NC1NC(=O)C(O)c1ccccc1 | 10.1021/jm00120a002 | |||
CHEMBL419997 | 170248 | 0 | None | - | 0 | Rat | 4.0 | pIC50 | = | 4 | Binding | ChEMBL | 403 | 4 | 3 | 4 | 2.8 | O=C1Nc2ccccc2C(c2ccccc2F)=NC1NC(=O)C(O)c1ccccc1 | 10.1021/jm00120a002 | |||
14208262 | 211298 | 0 | None | - | 0 | Rat | 4.0 | pIC50 | = | 4 | Binding | ChEMBL | 431 | 4 | 2 | 3 | 4.9 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccc(-c2ccccc2)cc1 | 10.1021/jm00120a002 | |||
CHEMBL72670 | 211298 | 0 | None | - | 0 | Rat | 4.0 | pIC50 | = | 4 | Binding | ChEMBL | 431 | 4 | 2 | 3 | 4.9 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccc(-c2ccccc2)cc1 | 10.1021/jm00120a002 | |||
2794055 | 74482 | 4 | None | - | 0 | Guinea pig | 4.0 | pIC50 | = | 4 | Binding | ChEMBL | 360 | 3 | 1 | 2 | 4.7 | O=C1Nc2ccc(Cl)cc2C(c2ccccc2)=N[C@@H]1Cc1ccccc1 | 10.1021/jm00390a019 | |||
CHEMBL1907712 | 74482 | 4 | None | - | 0 | Guinea pig | 4.0 | pIC50 | = | 4 | Binding | ChEMBL | 360 | 3 | 1 | 2 | 4.7 | O=C1Nc2ccc(Cl)cc2C(c2ccccc2)=N[C@@H]1Cc1ccccc1 | 10.1021/jm00390a019 | |||
15167780 | 74487 | 0 | None | - | 0 | Guinea pig | 4.0 | pIC50 | = | 4 | Binding | ChEMBL | 415 | 3 | 2 | 3 | 4.6 | O=C1Nc2ccccc2C1C[C@H]1N=C(c2ccccc2)c2cc(Cl)ccc2NC1=O | 10.1021/jm00390a019 | |||
CHEMBL1907723 | 74487 | 0 | None | - | 0 | Guinea pig | 4.0 | pIC50 | = | 4 | Binding | ChEMBL | 415 | 3 | 2 | 3 | 4.6 | O=C1Nc2ccccc2C1C[C@H]1N=C(c2ccccc2)c2cc(Cl)ccc2NC1=O | 10.1021/jm00390a019 | |||
15614736 | 174087 | 0 | None | - | 0 | Guinea pig | 4.0 | pIC50 | = | 4 | Binding | ChEMBL | 410 | 3 | 1 | 2 | 5.9 | O=C1Nc2ccc(Cl)cc2C(c2ccccc2)=NC1Cc1cccc2ccccc12 | 10.1021/jm00390a019 | |||
CHEMBL429391 | 174087 | 0 | None | - | 0 | Guinea pig | 4.0 | pIC50 | = | 4 | Binding | ChEMBL | 410 | 3 | 1 | 2 | 5.9 | O=C1Nc2ccc(Cl)cc2C(c2ccccc2)=NC1Cc1cccc2ccccc12 | 10.1021/jm00390a019 | |||
44359880 | 39103 | 0 | None | - | 0 | Rat | 4.0 | pIC50 | = | 4 | Binding | ChEMBL | 428 | 7 | 2 | 5 | 2.4 | CC(=O)NCSCC(=O)NCC1CN=C(c2ccccc2F)c2ccccc2N1C | 10.1021/jm00163a069 | |||
CHEMBL141048 | 39103 | 0 | None | - | 0 | Rat | 4.0 | pIC50 | = | 4 | Binding | ChEMBL | 428 | 7 | 2 | 5 | 2.4 | CC(=O)NCSCC(=O)NCC1CN=C(c2ccccc2F)c2ccccc2N1C | 10.1021/jm00163a069 | |||
44359841 | 123407 | 0 | None | - | 0 | Rat | 4.0 | pIC50 | = | 4 | Binding | ChEMBL | 498 | 7 | 1 | 4 | 6.5 | CCN(CC)c1ccc(NCC2CN=C(c3ccccc3F)c3ccccc3N2C)cc1C(F)(F)F | 10.1021/jm00163a069 | |||
CHEMBL336881 | 123407 | 0 | None | - | 0 | Rat | 4.0 | pIC50 | = | 4 | Binding | ChEMBL | 498 | 7 | 1 | 4 | 6.5 | CCN(CC)c1ccc(NCC2CN=C(c3ccccc3F)c3ccccc3N2C)cc1C(F)(F)F | 10.1021/jm00163a069 | |||
7216755 | 66314 | 7 | None | - | 0 | Rat | 4.0 | pIC50 | = | 4 | Binding | ChEMBL | 265 | 1 | 1 | 3 | 1.8 | CN1C(=O)[C@@H](N)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(00)80682-4 | |||
CHEMBL171651 | 66314 | 7 | None | - | 0 | Rat | 4.0 | pIC50 | = | 4 | Binding | ChEMBL | 265 | 1 | 1 | 3 | 1.8 | CN1C(=O)[C@@H](N)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(00)80682-4 | |||
71450869 | 91159 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 650 | 12 | 5 | 6 | 4.3 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCS(=O)(=O)O)c1ccccc1 | 10.1021/jm00092a007 | |||
CHEMBL2112338 | 91159 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 650 | 12 | 5 | 6 | 4.3 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCS(=O)(=O)O)c1ccccc1 | 10.1021/jm00092a007 | |||
CHEMBL2219559 | 91159 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 650 | 12 | 5 | 6 | 4.3 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCS(=O)(=O)O)c1ccccc1 | 10.1021/jm00092a007 | |||
10325770 | 137473 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 573 | 8 | 4 | 5 | 3.2 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)[C@@](Cc3ccccc3)(C(N)=O)C[C@H]12 | 10.1016/0960-894X(96)00160-6 | |||
CHEMBL368380 | 137473 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 573 | 8 | 4 | 5 | 3.2 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)[C@@](Cc3ccccc3)(C(N)=O)C[C@H]12 | 10.1016/0960-894X(96)00160-6 | |||
44349203 | 123832 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 455 | 7 | 3 | 4 | 3.6 | O=C(O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)NN1CCC2(CCCCC2)C1 | 10.1021/jm00079a003 | |||
CHEMBL339134 | 123832 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 455 | 7 | 3 | 4 | 3.6 | O=C(O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)NN1CCC2(CCCCC2)C1 | 10.1021/jm00079a003 | |||
45482109 | 204829 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 427 | 7 | 4 | 3 | 3.8 | O=C(Nc1ccccc1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 | 10.1016/j.bmc.2009.05.067 | |||
CHEMBL574062 | 204829 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 427 | 7 | 4 | 3 | 3.8 | O=C(Nc1ccccc1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 | 10.1016/j.bmc.2009.05.067 | |||
44408411 | 168089 | 0 | None | -2089 | 4 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 1242 | 31 | 11 | 15 | 4.4 | CCCC[C@@H](C(=O)N[C@@H](Cc1cn(C(C)=O)c2ccccc12)C(=O)O)N(C(=O)Nc1ccccc1Cl)C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)N(C)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O | 10.1021/jm050851n | |||
CHEMBL412331 | 168089 | 0 | None | -2089 | 4 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 1242 | 31 | 11 | 15 | 4.4 | CCCC[C@@H](C(=O)N[C@@H](Cc1cn(C(C)=O)c2ccccc12)C(=O)O)N(C(=O)Nc1ccccc1Cl)C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)N(C)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O | 10.1021/jm050851n | |||
44408484 | 144286 | 0 | None | -19498 | 4 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 1033 | 30 | 13 | 12 | 1.4 | CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm050851n | |||
CHEMBL375412 | 144286 | 0 | None | -19498 | 4 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 1033 | 30 | 13 | 12 | 1.4 | CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm050851n | |||
44418924 | 163661 | 0 | None | -19952 | 4 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 1031 | 27 | 13 | 12 | 0.2 | CCCC[C@H](NC(=O)[C@H](N)Cc1cc2ccccc2[nH]1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm061268p | |||
CHEMBL407198 | 163661 | 0 | None | -19952 | 4 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 1031 | 27 | 13 | 12 | 0.2 | CCCC[C@H](NC(=O)[C@H](N)Cc1cc2ccccc2[nH]1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm061268p | |||
CHEMBL333299 | 218170 | 0 | None | - | 0 | Guinea pig | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | None | None | None | C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00105a068 | |||||
10340882 | 32801 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 399 | 3 | 2 | 4 | 3.4 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3cccnc3N(C)C2=O)c1 | 10.1021/jm00078a018 | |||
CHEMBL135498 | 32801 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 399 | 3 | 2 | 4 | 3.4 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3cccnc3N(C)C2=O)c1 | 10.1021/jm00078a018 | |||
46235271 | 80423 | 2 | None | 2 | 2 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 649 | 7 | 1 | 6 | 6.7 | Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1021/acs.jmedchem.5b01110 | |||
CHEMBL2017835 | 80423 | 2 | None | 2 | 2 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 649 | 7 | 1 | 6 | 6.7 | Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1021/acs.jmedchem.5b01110 | |||
10256428 | 126466 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 529 | 9 | 4 | 4 | 4.9 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC12C[C@H]3C[C@@H](C1)C[C@@H](C2)C3)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
CHEMBL347278 | 126466 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 529 | 9 | 4 | 4 | 4.9 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC12C[C@H]3C[C@@H](C1)C[C@@H](C2)C3)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
108187 | 7713 | 37 | None | - | 5 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1021/jm00017a022 | |||
873 | 7713 | 37 | None | - | 5 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1021/jm00017a022 | |||
CHEMBL2062154 | 7713 | 37 | None | - | 5 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1021/jm00017a022 | |||
CHEMBL287735 | 7713 | 37 | None | - | 5 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1021/jm00017a022 | |||
CHEMBL205965 | 215948 | 0 | None | - | 3 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm050921q | |||||
44369590 | 126327 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 458 | 7 | 3 | 6 | 3.5 | Cc1cccc(NCNC2N=C(c3cc[nH]n3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1016/0960-894X(95)00557-A | |||
CHEMBL345880 | 126327 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 458 | 7 | 3 | 6 | 3.5 | Cc1cccc(NCNC2N=C(c3cc[nH]n3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1016/0960-894X(95)00557-A | |||
51353551 | 24906 | 16 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 605 | 8 | 3 | 5 | 5.0 | CC(C)N(C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(C(=O)O)c2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1016/j.bmcl.2015.03.051 | |||
CHEMBL1269257 | 24906 | 16 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 605 | 8 | 3 | 5 | 5.0 | CC(C)N(C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(C(=O)O)c2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1016/j.bmcl.2015.03.051 | |||
44353183 | 123554 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 555 | 8 | 3 | 4 | 5.2 | O=C(OC1C2CC3CC(C2)CC1C3)N1CCCC1(Cc1c[nH]c2ccccc12)C(=O)NC(CO)Cc1ccccc1 | 10.1016/S0960-894X(00)80156-0 | |||
CHEMBL337692 | 123554 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 555 | 8 | 3 | 4 | 5.2 | O=C(OC1C2CC3CC(C2)CC1C3)N1CCCC1(Cc1c[nH]c2ccccc12)C(=O)NC(CO)Cc1ccccc1 | 10.1016/S0960-894X(00)80156-0 | |||
71456173 | 85259 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 455 | 7 | 3 | 4 | 3.6 | O=C(O)CC[C@H](NC(=O)c1ccc(Cl)c(Cl)c1)C(=O)NN1CCC2(CCCC2)CC1 | 10.1021/jm00079a003 | |||
CHEMBL2111826 | 85259 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 455 | 7 | 3 | 4 | 3.6 | O=C(O)CC[C@H](NC(=O)c1ccc(Cl)c(Cl)c1)C(=O)NN1CCC2(CCCC2)CC1 | 10.1021/jm00079a003 | |||
10342469 | 205379 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 427 | 7 | 4 | 3 | 3.8 | O=C(Nc1ccccc1C(=O)N[C@H](Cc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 | 10.1016/j.bmc.2009.05.067 | |||
CHEMBL578650 | 205379 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 427 | 7 | 4 | 3 | 3.8 | O=C(Nc1ccccc1C(=O)N[C@H](Cc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 | 10.1016/j.bmc.2009.05.067 | |||
44283496 | 106950 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 527 | 9 | 2 | 3 | 6.1 | CC(=O)N(CCc1ccccc1)CC(C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1021/jm00086a017 | |||
CHEMBL288037 | 106950 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 527 | 9 | 2 | 3 | 6.1 | CC(=O)N(CCc1ccccc1)CC(C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1021/jm00086a017 | |||
10668688 | 214311 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 400 | 4 | 4 | 6 | 3.4 | Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(N)c2)c1 | 10.1021/jm970373j | |||
CHEMBL9465 | 214311 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 400 | 4 | 4 | 6 | 3.4 | Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(N)c2)c1 | 10.1021/jm970373j | |||
53465782 | 76184 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 455 | 9 | 4 | 3 | 4.6 | O=C(Nc1ccccc1C(=O)NC(CCCc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 | 10.1021/jm200438b | |||
CHEMBL1933101 | 76184 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 455 | 9 | 4 | 3 | 4.6 | O=C(Nc1ccccc1C(=O)NC(CCCc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 | 10.1021/jm200438b | |||
10793168 | 174672 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 570 | 7 | 1 | 3 | 6.9 | CC(C)N(C(=O)CN1C(=O)C(C)(Cc2c[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1021/jm960249k | |||
CHEMBL431212 | 174672 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 570 | 7 | 1 | 3 | 6.9 | CC(C)N(C(=O)CN1C(=O)C(C)(Cc2c[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1021/jm960249k | |||
9960964 | 92768 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 638 | 12 | 5 | 7 | 4.1 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCc1nnn[nH]1)c1ccccc1 | 10.1016/S0960-894X(00)80652-6 | |||
CHEMBL2304152 | 92768 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 638 | 12 | 5 | 7 | 4.1 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCc1nnn[nH]1)c1ccccc1 | 10.1016/S0960-894X(00)80652-6 | |||
10325426 | 114378 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 557 | 10 | 3 | 4 | 5.2 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccc1)CC(=O)O | 10.1016/S0960-894X(01)80769-1 | |||
CHEMBL318963 | 114378 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 557 | 10 | 3 | 4 | 5.2 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccc1)CC(=O)O | 10.1016/S0960-894X(01)80769-1 | |||
10165354 | 28918 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 529 | 9 | 4 | 4 | 4.7 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC(CO)Cc1ccccc1 | 10.1016/S0960-894X(00)80156-0 | |||
CHEMBL132233 | 28918 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 529 | 9 | 4 | 4 | 4.7 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC(CO)Cc1ccccc1 | 10.1016/S0960-894X(00)80156-0 | |||
44283132 | 127579 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 485 | 9 | 3 | 3 | 5.9 | CC(CNCCc1ccccc1)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1021/jm00086a017 | |||
CHEMBL35555 | 127579 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 485 | 9 | 3 | 3 | 5.9 | CC(CNCCc1ccccc1)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1021/jm00086a017 | |||
10624013 | 40312 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 464 | 6 | 3 | 4 | 4.1 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NN1CCCC1 | 10.1021/jm970065l | |||
CHEMBL142063 | 40312 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 464 | 6 | 3 | 4 | 4.1 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NN1CCCC1 | 10.1021/jm970065l | |||
14208240 | 109122 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 418 | 4 | 2 | 5 | 3.3 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccc([N+](=O)[O-])cc1 | 10.1021/jm00047a021 | |||
CHEMBL303724 | 109122 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 418 | 4 | 2 | 5 | 3.3 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccc([N+](=O)[O-])cc1 | 10.1021/jm00047a021 | |||
14208213 | 211387 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 362 | 3 | 3 | 3 | 2.7 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccc[nH]1 | 10.1021/jm00047a021 | |||
CHEMBL73272 | 211387 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 362 | 3 | 3 | 3 | 2.7 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccc[nH]1 | 10.1021/jm00047a021 | |||
9896825 | 109754 | 0 | None | - | 1 | Mouse | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 742 | 14 | 6 | 10 | 2.9 | Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCC(=O)NCCSCc4csc(N=C(N)N)n4)c3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
CHEMBL30656 | 109754 | 0 | None | - | 1 | Mouse | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 742 | 14 | 6 | 10 | 2.9 | Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCC(=O)NCCSCc4csc(N=C(N)N)n4)c3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
14208314 | 109700 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 495 | 3 | 1 | 3 | 3.9 | CN1C(=O)C(NC(=O)c2ccccc2I)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00047a021 | |||
CHEMBL306166 | 109700 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 495 | 3 | 1 | 3 | 3.9 | CN1C(=O)C(NC(=O)c2ccccc2I)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00047a021 | |||
14208199 | 109849 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 394 | 3 | 3 | 3 | 3.7 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1c[nH]c2ccccc12 | 10.1021/jm00047a021 | |||
CHEMBL307370 | 109849 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 394 | 3 | 3 | 3 | 3.7 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1c[nH]c2ccccc12 | 10.1021/jm00047a021 | |||
CHEMBL218327 | 216173 | 0 | None | -2630 | 4 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm050921q | |||||
14208272 | 74513 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 455 | 3 | 1 | 3 | 4.4 | CN1C(=O)[C@@H](NC(=O)c2ccc(C(F)(F)F)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL1907841 | 74513 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 455 | 3 | 1 | 3 | 4.4 | CN1C(=O)[C@@H](NC(=O)c2ccc(C(F)(F)F)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
14208208 | 176258 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 399 | 4 | 2 | 3 | 3.8 | O=C(/C=C/c1ccccc1)NC1N=C(c2ccccc2F)c2ccccc2NC1=O | 10.1021/jm00120a002 | |||
CHEMBL443009 | 176258 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 399 | 4 | 2 | 3 | 3.8 | O=C(/C=C/c1ccccc1)NC1N=C(c2ccccc2F)c2ccccc2NC1=O | 10.1021/jm00120a002 | |||
10260206 | 174253 | 0 | None | - | 0 | Guinea pig | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 918 | 21 | 8 | 8 | 4.9 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00028a015 | |||
CHEMBL429932 | 174253 | 0 | None | - | 0 | Guinea pig | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 918 | 21 | 8 | 8 | 4.9 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00028a015 | |||
CHEMBL415706 | 219978 | 0 | None | - | 0 | Guinea pig | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | None | None | None | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00028a015 | |||||
44341426 | 117116 | 0 | None | - | 0 | Guinea pig | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 514 | 13 | 3 | 4 | 6.0 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccc(O)cc12)NC(=O)c1cnc2ccccc2c1 | 10.1021/jm00116a002 | |||
CHEMBL324022 | 117116 | 0 | None | - | 0 | Guinea pig | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 514 | 13 | 3 | 4 | 6.0 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccc(O)cc12)NC(=O)c1cnc2ccccc2c1 | 10.1021/jm00116a002 | |||
9934162 | 34504 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 464 | 5 | 3 | 4 | 4.3 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(Cc3c[nH]cn3)C2=O)c1 | 10.1021/jm00078a018 | |||
CHEMBL137043 | 34504 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 464 | 5 | 3 | 4 | 4.3 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(Cc3c[nH]cn3)C2=O)c1 | 10.1021/jm00078a018 | |||
10649606 | 56390 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 519 | 6 | 3 | 4 | 4.5 | O=C(CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)Nc1ccccc1 | 10.1016/j.bmcl.2015.03.051 | |||
CHEMBL156605 | 56390 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 519 | 6 | 3 | 4 | 4.5 | O=C(CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)Nc1ccccc1 | 10.1016/j.bmcl.2015.03.051 | |||
10432393 | 107122 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 422 | 3 | 3 | 3 | 4.4 | O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2F)c2ccccc2NC1=O | 10.1021/jm00121a004 | |||
CHEMBL289533 | 107122 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 422 | 3 | 3 | 3 | 4.4 | O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2F)c2ccccc2NC1=O | 10.1021/jm00121a004 | |||
14208242 | 163202 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 493 | 6 | 1 | 5 | 4.0 | CCOC(=O)CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00121a004 | |||
CHEMBL40668 | 163202 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 493 | 6 | 1 | 5 | 4.0 | CCOC(=O)CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00121a004 | |||
14208240 | 109122 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 418 | 4 | 2 | 5 | 3.3 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccc([N+](=O)[O-])cc1 | 10.1021/jm00120a002 | |||
CHEMBL303724 | 109122 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 418 | 4 | 2 | 5 | 3.3 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccc([N+](=O)[O-])cc1 | 10.1021/jm00120a002 | |||
14208242 | 163202 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 493 | 6 | 1 | 5 | 4.0 | CCOC(=O)CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL40668 | 163202 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 493 | 6 | 1 | 5 | 4.0 | CCOC(=O)CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
14208213 | 211387 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 362 | 3 | 3 | 3 | 2.7 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccc[nH]1 | 10.1021/jm00120a002 | |||
CHEMBL73272 | 211387 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 362 | 3 | 3 | 3 | 2.7 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccc[nH]1 | 10.1021/jm00120a002 | |||
5279169 | 32971 | 1 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 404 | 3 | 3 | 3 | 4.3 | O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2NC1=O | 10.1021/jm00078a018 | |||
CHEMBL135715 | 32971 | 1 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 404 | 3 | 3 | 3 | 4.3 | O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2NC1=O | 10.1021/jm00078a018 | |||
10070678 | 127533 | 1 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 418 | 3 | 2 | 3 | 4.3 | CN1C(=O)[C@@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL355092 | 127533 | 1 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 418 | 3 | 2 | 3 | 4.3 | CN1C(=O)[C@@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
14208242 | 163202 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 493 | 6 | 1 | 5 | 4.0 | CCOC(=O)CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL40668 | 163202 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 493 | 6 | 1 | 5 | 4.0 | CCOC(=O)CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00078a018 | |||
90663976 | 113576 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 839 | 21 | 9 | 9 | 3.0 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccccc1O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
CHEMBL3144538 | 113576 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 839 | 21 | 9 | 9 | 3.0 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccccc1O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
14991577 | 170023 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 870 | 20 | 9 | 8 | 4.0 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1cc2cc(Cl)ccc2[nH]1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
CHEMBL418500 | 170023 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 870 | 20 | 9 | 8 | 4.0 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1cc2cc(Cl)ccc2[nH]1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
44381960 | 127057 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 474 | 3 | 3 | 4 | 4.6 | CN1C(=O)[C@@H](NC(=O)Nc2cc3c4ccccc4nc-3c[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(00)80682-4 | |||
CHEMBL352573 | 127057 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 474 | 3 | 3 | 4 | 4.6 | CN1C(=O)[C@@H](NC(=O)Nc2cc3c4ccccc4nc-3c[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(00)80682-4 | |||
44301037 | 107634 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 633 | 8 | 4 | 6 | 4.0 | CCS(=O)(=O)NC(=O)c1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)c3ccc(C)cc3N(CC(=O)NC(C)(C)C)C2=O)c1 | 10.1016/0960-894X(95)00327-P | |||
CHEMBL293490 | 107634 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 633 | 8 | 4 | 6 | 4.0 | CCS(=O)(=O)NC(=O)c1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)c3ccc(C)cc3N(CC(=O)NC(C)(C)C)C2=O)c1 | 10.1016/0960-894X(95)00327-P | |||
10319892 | 65865 | 2 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 418 | 3 | 2 | 3 | 4.3 | CN1C(=O)[C@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00121a004 | |||
CHEMBL169661 | 65865 | 2 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 418 | 3 | 2 | 3 | 4.3 | CN1C(=O)[C@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00121a004 | |||
14208199 | 109849 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 394 | 3 | 3 | 3 | 3.7 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1c[nH]c2ccccc12 | 10.1021/jm00120a002 | |||
CHEMBL307370 | 109849 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 394 | 3 | 3 | 3 | 3.7 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1c[nH]c2ccccc12 | 10.1021/jm00120a002 | |||
10182876 | 210901 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 457 | 7 | 1 | 3 | 5.1 | CCCCCc1ccc(C(=O)NC2N=C(c3ccccc3F)c3ccccc3N(C)C2=O)cc1 | 10.1021/jm00120a002 | |||
CHEMBL70361 | 210901 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 457 | 7 | 1 | 3 | 5.1 | CCCCCc1ccc(C(=O)NC2N=C(c3ccccc3F)c3ccccc3N(C)C2=O)cc1 | 10.1021/jm00120a002 | |||
14208280 | 74462 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 335 | 3 | 1 | 3 | 2.6 | CC(C)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2N(C)C1=O | 10.1021/jm00120a002 | |||
CHEMBL1907665 | 74462 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 335 | 3 | 1 | 3 | 2.6 | CC(C)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2N(C)C1=O | 10.1021/jm00120a002 | |||
14208315 | 74511 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 495 | 3 | 1 | 3 | 3.9 | CN1C(=O)[C@@H](NC(=O)c2ccccc2I)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL1907839 | 74511 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 495 | 3 | 1 | 3 | 3.9 | CN1C(=O)[C@@H](NC(=O)c2ccccc2I)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
14802528 | 125243 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 642 | 14 | 5 | 5 | 5.1 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](CNC(=O)CCCC(=O)O)Cc1ccccc1 | 10.1021/jm00105a062 | |||
CHEMBL341281 | 125243 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 642 | 14 | 5 | 5 | 5.1 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](CNC(=O)CCCC(=O)O)Cc1ccccc1 | 10.1021/jm00105a062 | |||
15104622 | 16805 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 476 | 13 | 3 | 2 | 6.4 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)Nc1cccc(C)c1 | 10.1021/jm00116a002 | |||
CHEMBL115093 | 16805 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 476 | 13 | 3 | 2 | 6.4 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)Nc1cccc(C)c1 | 10.1021/jm00116a002 | |||
14720389 | 171862 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 373 | 10 | 3 | 3 | 2.8 | CCCN(CCC)C(=O)[C@H](CCC(=O)O)NC(=O)c1cc2ccccc2[nH]1 | 10.1021/jm00164a020 | |||
CHEMBL422701 | 171862 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 373 | 10 | 3 | 3 | 2.8 | CCCN(CCC)C(=O)[C@H](CCC(=O)O)NC(=O)c1cc2ccccc2[nH]1 | 10.1021/jm00164a020 | |||
10075297 | 122284 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 518 | 6 | 3 | 5 | 4.4 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)Nc3ccncc3)C2=O)c1 | 10.1021/jm00078a018 | |||
CHEMBL335239 | 122284 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 518 | 6 | 3 | 5 | 4.4 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)Nc3ccncc3)C2=O)c1 | 10.1021/jm00078a018 | |||
14991564 | 113580 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 827 | 21 | 9 | 9 | 2.5 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
CHEMBL3144541 | 113580 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 827 | 21 | 9 | 9 | 2.5 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
44334338 | 115690 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 547 | 9 | 2 | 5 | 4.2 | Cc1cccc(NC(=O)N[C@H](CS(=O)(=O)Cc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
CHEMBL321107 | 115690 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 547 | 9 | 2 | 5 | 4.2 | Cc1cccc(NC(=O)N[C@H](CS(=O)(=O)Cc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
10319892 | 65865 | 2 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 418 | 3 | 2 | 3 | 4.3 | CN1C(=O)[C@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(00)80682-4 | |||
CHEMBL169661 | 65865 | 2 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 418 | 3 | 2 | 3 | 4.3 | CN1C(=O)[C@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(00)80682-4 | |||
14519983 | 126754 | 0 | None | - | 0 | Guinea pig | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 441 | 14 | 2 | 4 | 4.4 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1ccc2ncccc2c1 | 10.1021/jm00124a003 | |||
CHEMBL349857 | 126754 | 0 | None | - | 0 | Guinea pig | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 441 | 14 | 2 | 4 | 4.4 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1ccc2ncccc2c1 | 10.1021/jm00124a003 | |||
14519979 | 16302 | 0 | None | - | 0 | Guinea pig | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 440 | 14 | 2 | 3 | 5.0 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1cccc2ccccc12 | 10.1021/jm00124a003 | |||
CHEMBL112215 | 16302 | 0 | None | - | 0 | Guinea pig | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 440 | 14 | 2 | 3 | 5.0 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1cccc2ccccc12 | 10.1021/jm00124a003 | |||
44349070 | 171270 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 421 | 7 | 3 | 4 | 3.0 | O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NN1CCC2(CCCC2)CC1 | 10.1021/jm00079a003 | |||
CHEMBL421438 | 171270 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 421 | 7 | 3 | 4 | 3.0 | O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NN1CCC2(CCCC2)CC1 | 10.1021/jm00079a003 | |||
CHEMBL103485 | 215236 | 0 | None | - | 0 | Guinea pig | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | None | None | None | CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00173a006 | |||||
14208251 | 84602 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 403 | 3 | 1 | 3 | 3.9 | CN1C(=O)[C@H](NC(=O)c2ccccc2Cl)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL2092870 | 84602 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 403 | 3 | 1 | 3 | 3.9 | CN1C(=O)[C@H](NC(=O)c2ccccc2Cl)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
15167804 | 74485 | 0 | None | - | 0 | Guinea pig | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 455 | 6 | 2 | 3 | 4.6 | O=C(O)CCN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00390a019 | |||
CHEMBL1907719 | 74485 | 0 | None | - | 0 | Guinea pig | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 455 | 6 | 2 | 3 | 4.6 | O=C(O)CCN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00390a019 | |||
45482485 | 204790 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 486 | 8 | 3 | 6 | 3.8 | Cn1c(C(=O)Nc2ccccc2C(=O)NC(Cc2ccccc2)C(=O)O)cc2cc([N+](=O)[O-])ccc21 | 10.1016/j.bmc.2009.05.067 | |||
CHEMBL573793 | 204790 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 486 | 8 | 3 | 6 | 3.8 | Cn1c(C(=O)Nc2ccccc2C(=O)NC(Cc2ccccc2)C(=O)O)cc2cc([N+](=O)[O-])ccc21 | 10.1016/j.bmc.2009.05.067 | |||
21842317 | 128458 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 482 | 5 | 2 | 4 | 4.9 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1016/0960-894X(95)00557-A | |||
CHEMBL358646 | 128458 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 482 | 5 | 2 | 4 | 4.9 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1016/0960-894X(95)00557-A | |||
21842317 | 128458 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 482 | 5 | 2 | 4 | 4.9 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1016/0960-894X(95)00556-9 | |||
CHEMBL358646 | 128458 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 482 | 5 | 2 | 4 | 4.9 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1016/0960-894X(95)00556-9 | |||
10322988 | 16920 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 482 | 5 | 2 | 4 | 4.9 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1021/jm960669+ | |||
CHEMBL115772 | 16920 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 482 | 5 | 2 | 4 | 4.9 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1021/jm960669+ | |||
44349434 | 123793 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 396 | 11 | 3 | 3 | 3.6 | CCC(C)(CC)CCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 | 10.1021/jm00079a003 | |||
CHEMBL338929 | 123793 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 396 | 11 | 3 | 3 | 3.6 | CCC(C)(CC)CCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 | 10.1021/jm00079a003 | |||
5311201 | 214174 | 35 | None | - | 6 | Mouse | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
5311201 | 214174 | 35 | None | - | 6 | Mouse | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(96)00249-1 | |||
CHEMBL9387 | 214174 | 35 | None | - | 6 | Mouse | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
CHEMBL9387 | 214174 | 35 | None | - | 6 | Mouse | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(96)00249-1 | |||
10722103 | 118251 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 588 | 8 | 1 | 6 | 5.3 | COc1ccc(N(C(=O)CN2C(=O)C(Cc3n[nH]c4ncccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm970265x | |||
CHEMBL327656 | 118251 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 588 | 8 | 1 | 6 | 5.3 | COc1ccc(N(C(=O)CN2C(=O)C(Cc3n[nH]c4ncccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm970265x | |||
73349872 | 95976 | 1 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 616 | 12 | 5 | 5 | 5.2 | CC1(C)[C@H]2CC[C@@]1(C)[C@H](OC(=O)N[C@](C)(Cc1c[nH]c3ccccc13)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1)C2 | 10.1016/0960-894X(96)00160-6 | |||
CHEMBL2367718 | 95976 | 1 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 616 | 12 | 5 | 5 | 5.2 | CC1(C)[C@H]2CC[C@@]1(C)[C@H](OC(=O)N[C@](C)(Cc1c[nH]c3ccccc13)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1)C2 | 10.1016/0960-894X(96)00160-6 | |||
CHEMBL2367719 | 95976 | 1 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 616 | 12 | 5 | 5 | 5.2 | CC1(C)[C@H]2CC[C@@]1(C)[C@H](OC(=O)N[C@](C)(Cc1c[nH]c3ccccc13)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1)C2 | 10.1016/0960-894X(96)00160-6 | |||
11442153 | 204977 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 444 | 7 | 3 | 4 | 4.6 | O=C(Nc1ccccc1C(=O)NC(Cc1ccccc1)C(=O)O)c1cc2ccccc2s1 | 10.1016/j.bmc.2009.05.067 | |||
CHEMBL575161 | 204977 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 444 | 7 | 3 | 4 | 4.6 | O=C(Nc1ccccc1C(=O)NC(Cc1ccccc1)C(=O)O)c1cc2ccccc2s1 | 10.1016/j.bmc.2009.05.067 | |||
10789434 | 213415 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 444 | 6 | 3 | 8 | 3.1 | CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccnc2)c1 | 10.1021/jm970373j | |||
CHEMBL8921 | 213415 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 444 | 6 | 3 | 8 | 3.1 | CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccnc2)c1 | 10.1021/jm970373j | |||
73349872 | 95976 | 1 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 616 | 12 | 5 | 5 | 5.2 | CC1(C)[C@H]2CC[C@@]1(C)[C@H](OC(=O)N[C@](C)(Cc1c[nH]c3ccccc13)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1)C2 | 10.1021/jm0498755 | |||
CHEMBL2367718 | 95976 | 1 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 616 | 12 | 5 | 5 | 5.2 | CC1(C)[C@H]2CC[C@@]1(C)[C@H](OC(=O)N[C@](C)(Cc1c[nH]c3ccccc13)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1)C2 | 10.1021/jm0498755 | |||
CHEMBL2367719 | 95976 | 1 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 616 | 12 | 5 | 5 | 5.2 | CC1(C)[C@H]2CC[C@@]1(C)[C@H](OC(=O)N[C@](C)(Cc1c[nH]c3ccccc13)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1)C2 | 10.1021/jm0498755 | |||
10839478 | 117434 | 1 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 512 | 6 | 2 | 6 | 4.1 | CN(C)c1cccc(NC(=O)N[C@@H]2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1021/jm960669+ | |||
CHEMBL325863 | 117434 | 1 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 512 | 6 | 2 | 6 | 4.1 | CN(C)c1cccc(NC(=O)N[C@@H]2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1021/jm960669+ | |||
15104595 | 16864 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 498 | 13 | 2 | 3 | 6.3 | CCCCCN(CCCCC)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1cnc2ccccc2c1 | 10.1021/jm00116a002 | |||
CHEMBL115456 | 16864 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 498 | 13 | 2 | 3 | 6.3 | CCCCCN(CCCCC)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1cnc2ccccc2c1 | 10.1021/jm00116a002 | |||
138106885 | 173690 | 75 | None | -1 | 4 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 853 | 10 | 4 | 14 | 3.7 | CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C | nan | |||
36314 | 173690 | 75 | None | -1 | 4 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 853 | 10 | 4 | 14 | 3.7 | CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C | nan | |||
CHEMBL428647 | 173690 | 75 | None | -1 | 4 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 853 | 10 | 4 | 14 | 3.7 | CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C | nan | |||
44592082 | 185922 | 0 | None | - | 0 | Guinea pig | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 411 | 8 | 4 | 4 | 3.4 | CSCC[C@@H](NC(=O)c1ccccc1NC(=O)c1cc2ccccc2[nH]1)C(=O)O | 10.1016/j.bmc.2009.02.012 | |||
CHEMBL472079 | 185922 | 0 | None | - | 0 | Guinea pig | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 411 | 8 | 4 | 4 | 3.4 | CSCC[C@@H](NC(=O)c1ccccc1NC(=O)c1cc2ccccc2[nH]1)C(=O)O | 10.1016/j.bmc.2009.02.012 | |||
10413579 | 123861 | 0 | None | - | 0 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 498 | 5 | 3 | 3 | 5.0 | Cc1ccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)c3ccccc3N(CC(=O)NC(C)(C)C)C2=O)cc1 | 10.1021/jm00048a015 | |||
CHEMBL339260 | 123861 | 0 | None | - | 0 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 498 | 5 | 3 | 3 | 5.0 | Cc1ccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)c3ccccc3N(CC(=O)NC(C)(C)C)C2=O)cc1 | 10.1021/jm00048a015 | |||
44283152 | 106630 | 0 | None | - | 0 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 501 | 10 | 4 | 4 | 4.8 | O=C(NC(CNC(CO)Cc1ccccc1)Cc1c[nH]c2ccccc12)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1021/jm00086a017 | |||
CHEMBL285762 | 106630 | 0 | None | - | 0 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 501 | 10 | 4 | 4 | 4.8 | O=C(NC(CNC(CO)Cc1ccccc1)Cc1c[nH]c2ccccc12)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1021/jm00086a017 | |||
44591978 | 190688 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 533 | 10 | 4 | 4 | 5.4 | O=C(Nc1ccccc1C(=O)NC(Cc1ccc(OCc2ccccc2)cc1)C(=O)O)c1cc2ccccc2[nH]1 | 10.1016/j.bmc.2009.02.012 | |||
CHEMBL481265 | 190688 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 533 | 10 | 4 | 4 | 5.4 | O=C(Nc1ccccc1C(=O)NC(Cc1ccc(OCc2ccccc2)cc1)C(=O)O)c1cc2ccccc2[nH]1 | 10.1016/j.bmc.2009.02.012 | |||
19766227 | 39977 | 0 | None | - | 0 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 469 | 6 | 3 | 4 | 3.6 | CN1c2ccccc2C(c2ccccc2F)=NCC1CNC(=O)C(N)Cc1c[nH]c2ccccc12 | 10.1021/jm00163a069 | |||
CHEMBL141786 | 39977 | 0 | None | - | 0 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 469 | 6 | 3 | 4 | 3.6 | CN1c2ccccc2C(c2ccccc2F)=NCC1CNC(=O)C(N)Cc1c[nH]c2ccccc12 | 10.1021/jm00163a069 | |||
132190 | 127115 | 18 | None | - | 0 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 435 | 3 | 2 | 2 | 4.9 | O=C1NN(C(=O)Nc2ccc(Br)cc2)C(c2ccccc2)C1c1ccccc1 | 10.1016/S0960-894X(00)80684-8 | |||
CHEMBL352949 | 127115 | 18 | None | - | 0 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 435 | 3 | 2 | 2 | 4.9 | O=C1NN(C(=O)Nc2ccc(Br)cc2)C(c2ccccc2)C1c1ccccc1 | 10.1016/S0960-894X(00)80684-8 | |||
10373378 | 56438 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 854 | 20 | 8 | 8 | 4.2 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)C | 10.1021/jm00031a013 | |||
CHEMBL156642 | 56438 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 854 | 20 | 8 | 8 | 4.2 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)C | 10.1021/jm00031a013 | |||
10530757 | 125341 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 553 | 10 | 3 | 7 | 3.6 | COC(=O)CC(CC(=O)OC)NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 | 10.1021/jm970065l | |||
CHEMBL341560 | 125341 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 553 | 10 | 3 | 7 | 3.6 | COC(=O)CC(CC(=O)OC)NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 | 10.1021/jm970065l | |||
44287092 | 107237 | 0 | None | - | 0 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 824 | 21 | 7 | 7 | 5.2 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)NCCCCC(=O)N(C)C(Cc1ccccc1)C(N)=O | 10.1021/jm00037a005 | |||
CHEMBL290702 | 107237 | 0 | None | - | 0 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 824 | 21 | 7 | 7 | 5.2 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)NCCCCC(=O)N(C)C(Cc1ccccc1)C(N)=O | 10.1021/jm00037a005 | |||
44368382 | 52113 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 511 | 9 | 4 | 4 | 4.5 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1CCCCC1Cl)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
CHEMBL152682 | 52113 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 511 | 9 | 4 | 4 | 4.5 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1CCCCC1Cl)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
44286961 | 168846 | 0 | None | - | 0 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 824 | 22 | 8 | 7 | 5.3 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)NCCCCCC(=O)NC(Cc1ccccc1)C(N)=O | 10.1021/jm00037a005 | |||
CHEMBL416064 | 168846 | 0 | None | - | 0 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 824 | 22 | 8 | 7 | 5.3 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)NCCCCCC(=O)NC(Cc1ccccc1)C(N)=O | 10.1021/jm00037a005 | |||
10478431 | 16671 | 9 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 440 | 14 | 2 | 3 | 5.0 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1ccc2ccccc2c1 | 10.1021/jm00124a003 | |||
CHEMBL114325 | 16671 | 9 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 440 | 14 | 2 | 3 | 5.0 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1ccc2ccccc2c1 | 10.1021/jm00124a003 | |||
127050962 | 147524 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 283 | 3 | 1 | 2 | 2.6 | CC(C)CN1C(=O)C=C(Cl)C1(O)c1ccc(F)cc1 | 10.1039/C6MD00052E | |||
CHEMBL3818164 | 147524 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 283 | 3 | 1 | 2 | 2.6 | CC(C)CN1C(=O)C=C(Cl)C1(O)c1ccc(F)cc1 | 10.1039/C6MD00052E | |||
10478431 | 16671 | 9 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 440 | 14 | 2 | 3 | 5.0 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1ccc2ccccc2c1 | 10.1021/jm00116a002 | |||
CHEMBL114325 | 16671 | 9 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 440 | 14 | 2 | 3 | 5.0 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1ccc2ccccc2c1 | 10.1021/jm00116a002 | |||
10919004 | 85207 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 590 | 7 | 3 | 7 | 4.0 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3ccc([N+](=O)[O-])cc3)C(=O)C[C@@H]12 | 10.1021/jm010813d | |||
CHEMBL2111547 | 85207 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 590 | 7 | 3 | 7 | 4.0 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3ccc([N+](=O)[O-])cc3)C(=O)C[C@@H]12 | 10.1021/jm010813d | |||
10074366 | 127376 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 491 | 9 | 4 | 4 | 4.5 | C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
CHEMBL3349028 | 127376 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 491 | 9 | 4 | 4 | 4.5 | C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
CHEMBL3545866 | 127376 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 491 | 9 | 4 | 4 | 4.5 | C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
10032955 | 174814 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 742 | 17 | 7 | 6 | 5.8 | Cc1ccccc1NC(=O)NCCCC[C@H](CNC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3)NC(=O)CCC(=O)O | 10.1021/jm00017a022 | |||
CHEMBL432256 | 174814 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 742 | 17 | 7 | 6 | 5.8 | Cc1ccccc1NC(=O)NCCCC[C@H](CNC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3)NC(=O)CCC(=O)O | 10.1021/jm00017a022 | |||
52949124 | 7663 | 4 | None | - | 2 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1016/j.bmcl.2010.08.115 | |||
9055 | 7663 | 4 | None | - | 2 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1016/j.bmcl.2010.08.115 | |||
CHEMBL1269258 | 7663 | 4 | None | - | 2 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1016/j.bmcl.2010.08.115 | |||
DB12694 | 7663 | 4 | None | - | 2 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1016/j.bmcl.2010.08.115 | |||
13953715 | 201455 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 428 | 3 | 2 | 5 | 4.6 | O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2-n2cnnc21 | 10.1021/jm00396a028 | |||
CHEMBL53234 | 201455 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 428 | 3 | 2 | 5 | 4.6 | O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2-n2cnnc21 | 10.1021/jm00396a028 | |||
127050298 | 147618 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 265 | 1 | 1 | 2 | 2.6 | CC(C)(C)N1C(=O)C=C(Cl)C1(O)c1ccccc1 | 10.1039/C6MD00052E | |||
CHEMBL3819315 | 147618 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 265 | 1 | 1 | 2 | 2.6 | CC(C)(C)N1C(=O)C=C(Cl)C1(O)c1ccccc1 | 10.1039/C6MD00052E | |||
14208233 | 211296 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 490 | 3 | 3 | 3 | 4.6 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1cc2cc(Br)ccc2[nH]1 | 10.1021/jm00120a002 | |||
CHEMBL72667 | 211296 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 490 | 3 | 3 | 3 | 4.6 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1cc2cc(Br)ccc2[nH]1 | 10.1021/jm00120a002 | |||
44341429 | 117229 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 498 | 13 | 2 | 3 | 6.3 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccc2ccccc2n1 | 10.1021/jm00116a002 | |||
CHEMBL324652 | 117229 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 498 | 13 | 2 | 3 | 6.3 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccc2ccccc2n1 | 10.1021/jm00116a002 | |||
14888719 | 84011 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 1041 | 29 | 11 | 14 | -0.1 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@@H](Cc1ccc(-c2nn[nH]n2)cc1)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00107a037 | |||
CHEMBL2079547 | 84011 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 1041 | 29 | 11 | 14 | -0.1 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@@H](Cc1ccc(-c2nn[nH]n2)cc1)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00107a037 | |||
44370694 | 54784 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 488 | 15 | 2 | 4 | 4.8 | CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)N1CCCC1)NC(=O)Nc1cccc(OC)c1 | 10.1021/jm00164a020 | |||
CHEMBL155017 | 54784 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 488 | 15 | 2 | 4 | 4.8 | CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)N1CCCC1)NC(=O)Nc1cccc(OC)c1 | 10.1021/jm00164a020 | |||
10459108 | 35182 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 513 | 8 | 2 | 5 | 3.9 | CCN(CC)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(OC)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL137516 | 35182 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 513 | 8 | 2 | 5 | 3.9 | CCN(CC)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(OC)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
9977368 | 123026 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 385 | 3 | 2 | 4 | 3.0 | CN1C(=O)C(NC(=O)Nc2cccnc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL335865 | 123026 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 385 | 3 | 2 | 4 | 3.0 | CN1C(=O)C(NC(=O)Nc2cccnc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
90663992 | 113598 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 866 | 22 | 8 | 9 | 3.3 | CN(C)c1ccc(/C=C\C(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 | 10.1021/jm00089a010 | |||
CHEMBL3144561 | 113598 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 866 | 22 | 8 | 9 | 3.3 | CN(C)c1ccc(/C=C\C(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 | 10.1021/jm00089a010 | |||
14991536 | 113604 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 841 | 22 | 9 | 9 | 2.9 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
CHEMBL3144567 | 113604 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 841 | 22 | 9 | 9 | 2.9 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
44279861 | 109961 | 0 | None | - | 1 | Mouse | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 726 | 14 | 6 | 9 | 3.1 | CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCC(=O)NCCSCc3csc(N=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00248-X | |||
CHEMBL30821 | 109961 | 0 | None | - | 1 | Mouse | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 726 | 14 | 6 | 9 | 3.1 | CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCC(=O)NCCSCc3csc(N=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00248-X | |||
23844129 | 120276 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 497 | 6 | 3 | 5 | 4.7 | CNc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1021/jm960669+ | |||
CHEMBL332024 | 120276 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 497 | 6 | 3 | 5 | 4.7 | CNc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1021/jm960669+ | |||
14208233 | 211296 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 490 | 3 | 3 | 3 | 4.6 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1cc2cc(Br)ccc2[nH]1 | 10.1021/jm00047a021 | |||
CHEMBL72667 | 211296 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 490 | 3 | 3 | 3 | 4.6 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1cc2cc(Br)ccc2[nH]1 | 10.1021/jm00047a021 | |||
10721792 | 174565 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 571 | 7 | 1 | 4 | 6.3 | CC(C)N(C(=O)CN1C(=O)C(C)(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1021/jm960249k | |||
CHEMBL430451 | 174565 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 571 | 7 | 1 | 4 | 6.3 | CC(C)N(C(=O)CN1C(=O)C(C)(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1021/jm960249k | |||
10392653 | 125819 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 544 | 5 | 2 | 5 | 3.4 | CN1CCN(C(=O)CN2C(=O)C(NC(=O)Nc3ccc(Cl)cc3)N=C(c3ccccc3)c3ccccc32)CC1 | 10.1016/S0960-894X(00)80683-6 | |||
CHEMBL342640 | 125819 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 544 | 5 | 2 | 5 | 3.4 | CN1CCN(C(=O)CN2C(=O)C(NC(=O)Nc3ccc(Cl)cc3)N=C(c3ccccc3)c3ccccc32)CC1 | 10.1016/S0960-894X(00)80683-6 | |||
10456021 | 214287 | 1 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 442 | 4 | 2 | 5 | 3.4 | COC(=O)c1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm970373j | |||
CHEMBL9449 | 214287 | 1 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 442 | 4 | 2 | 5 | 3.4 | COC(=O)c1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm970373j | |||
21842327 | 52817 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 468 | 6 | 2 | 4 | 4.6 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)C)C2=O)c1 | 10.1016/0960-894X(95)00556-9 | |||
CHEMBL153308 | 52817 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 468 | 6 | 2 | 4 | 4.6 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)C)C2=O)c1 | 10.1016/0960-894X(95)00556-9 | |||
11316391 | 204657 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 431 | 7 | 4 | 3 | 3.6 | O=C(Nc1ccccc1C(=O)NC(Cc1ccccc1)C(=O)O)c1cc2c([nH]1)CCCC2 | 10.1016/j.bmc.2009.05.067 | |||
CHEMBL572650 | 204657 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 431 | 7 | 4 | 3 | 3.6 | O=C(Nc1ccccc1C(=O)NC(Cc1ccccc1)C(=O)O)c1cc2c([nH]1)CCCC2 | 10.1016/j.bmc.2009.05.067 | |||
44382698 | 66246 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 742 | 15 | 5 | 7 | 5.3 | O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccc(OS(=O)(=O)O)cc1)NCCc1ccccc1 | 10.1016/S0960-894X(00)80687-3 | |||
CHEMBL171375 | 66246 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 742 | 15 | 5 | 7 | 5.3 | O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccc(OS(=O)(=O)O)cc1)NCCc1ccccc1 | 10.1016/S0960-894X(00)80687-3 | |||
44370446 | 126379 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 467 | 15 | 2 | 4 | 5.4 | CCCCCN(CCCCC)C(=O)C(CCC(=O)OCC)NC(=O)Nc1ccc(Cl)cc1 | 10.1021/jm00164a020 | |||
CHEMBL346361 | 126379 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 467 | 15 | 2 | 4 | 5.4 | CCCCCN(CCCCC)C(=O)C(CCC(=O)OCC)NC(=O)Nc1ccc(Cl)cc1 | 10.1021/jm00164a020 | |||
10392653 | 125819 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 544 | 5 | 2 | 5 | 3.4 | CN1CCN(C(=O)CN2C(=O)C(NC(=O)Nc3ccc(Cl)cc3)N=C(c3ccccc3)c3ccccc32)CC1 | 10.1021/jm00078a018 | |||
CHEMBL342640 | 125819 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 544 | 5 | 2 | 5 | 3.4 | CN1CCN(C(=O)CN2C(=O)C(NC(=O)Nc3ccc(Cl)cc3)N=C(c3ccccc3)c3ccccc32)CC1 | 10.1021/jm00078a018 | |||
10070677 | 168503 | 15 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 418 | 3 | 2 | 3 | 4.3 | CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL41361 | 168503 | 15 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 418 | 3 | 2 | 3 | 4.3 | CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
10456021 | 214287 | 1 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 442 | 4 | 2 | 5 | 3.4 | COC(=O)c1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00078a018 | |||
CHEMBL9449 | 214287 | 1 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 442 | 4 | 2 | 5 | 3.4 | COC(=O)c1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00078a018 | |||
CHEMBL338056 | 218383 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00099a005 | |||||
15673180 | 92772 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 681 | 13 | 6 | 8 | 3.9 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)Nc1nn[nH]n1)c1ccccc1 | 10.1016/S0960-894X(00)80652-6 | |||
CHEMBL2304157 | 92772 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 681 | 13 | 6 | 8 | 3.9 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)Nc1nn[nH]n1)c1ccccc1 | 10.1016/S0960-894X(00)80652-6 | |||
CHEMBL3142686 | 217908 | 0 | None | - | 0 | Guinea pig | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | None | None | None | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||||
44272230 | 73849 | 0 | None | - | 0 | Mouse | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 442 | 6 | 3 | 3 | 2.9 | C[C@H](NC(=O)C1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1)C(=O)NCCc1ccccc1 | 10.1016/S0960-894X(00)80644-7 | |||
CHEMBL18727 | 73849 | 0 | None | - | 0 | Mouse | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 442 | 6 | 3 | 3 | 2.9 | C[C@H](NC(=O)C1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1)C(=O)NCCc1ccccc1 | 10.1016/S0960-894X(00)80644-7 | |||
14208310 | 74515 | 0 | None | - | 0 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 439 | 7 | 1 | 3 | 5.0 | CCCCCc1ccc(C(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc1 | 10.1021/jm00120a002 | |||
CHEMBL1907843 | 74515 | 0 | None | - | 0 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 439 | 7 | 1 | 3 | 5.0 | CCCCCc1ccc(C(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc1 | 10.1021/jm00120a002 | |||
10454826 | 106115 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 420 | 3 | 2 | 3 | 4.5 | Cc1cccc(NC(=O)N[C@@H]2C[C@H](N3CCCCCC3)c3ccccc3N(C)C2=O)c1 | 10.1016/0960-894X(95)00234-K | |||
CHEMBL282294 | 106115 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 420 | 3 | 2 | 3 | 4.5 | Cc1cccc(NC(=O)N[C@@H]2C[C@H](N3CCCCCC3)c3ccccc3N(C)C2=O)c1 | 10.1016/0960-894X(95)00234-K | |||
10838675 | 213992 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 487 | 8 | 3 | 8 | 4.1 | CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(OCC)c2)c1 | 10.1021/jm970373j | |||
CHEMBL9267 | 213992 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 487 | 8 | 3 | 8 | 4.1 | CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(OCC)c2)c1 | 10.1021/jm970373j | |||
10279334 | 131835 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 513 | 8 | 2 | 3 | 5.7 | CN(CCc1ccccc1)C(=O)C(C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1021/jm00086a017 | |||
CHEMBL36443 | 131835 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 513 | 8 | 2 | 3 | 5.7 | CN(CCc1ccccc1)C(=O)C(C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1021/jm00086a017 | |||
10253714 | 32266 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 460 | 4 | 2 | 3 | 5.3 | CN1C(=O)C(NC(=O)Nc2cccc(-c3ccccc3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL135060 | 32266 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 460 | 4 | 2 | 3 | 5.3 | CN1C(=O)C(NC(=O)Nc2cccc(-c3ccccc3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
15177358 | 105847 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 515 | 9 | 4 | 4 | 4.6 | O=C(NC(Cc1c[nH]c2ccccc12)NC(=O)C(CO)Cc1ccccc1)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1021/jm00086a017 | |||
CHEMBL280502 | 105847 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 515 | 9 | 4 | 4 | 4.6 | O=C(NC(Cc1c[nH]c2ccccc12)NC(=O)C(CO)Cc1ccccc1)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1021/jm00086a017 | |||
71457981 | 85303 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 1147 | 14 | 6 | 10 | 9.0 | CC(C)(C)OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@@H]12.CC(C)(C)OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@H]12 | 10.1021/jm991078x | |||
CHEMBL2111993 | 85303 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 1147 | 14 | 6 | 10 | 9.0 | CC(C)(C)OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@@H]12.CC(C)(C)OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@H]12 | 10.1021/jm991078x | |||
10720403 | 126208 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 507 | 6 | 4 | 4 | 4.8 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H]1CCCCC[C@H]1O | 10.1021/jm970065l | |||
CHEMBL344882 | 126208 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 507 | 6 | 4 | 4 | 4.8 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H]1CCCCC[C@H]1O | 10.1021/jm970065l | |||
13605417 | 214347 | 4 | None | - | 1 | Guinea pig | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 458 | 14 | 2 | 3 | 5.2 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1ccc(Cl)c(Cl)c1 | 10.1021/jm00124a003 | |||
CHEMBL9485 | 214347 | 4 | None | - | 1 | Guinea pig | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 458 | 14 | 2 | 3 | 5.2 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1ccc(Cl)c(Cl)c1 | 10.1021/jm00124a003 | |||
44359338 | 175445 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 489 | 6 | 3 | 3 | 5.3 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1CC2CCC1C2 | 10.1021/jm970065l | |||
CHEMBL436411 | 175445 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 489 | 6 | 3 | 3 | 5.3 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1CC2CCC1C2 | 10.1021/jm970065l | |||
9960432 | 46198 | 5 | None | -12 | 2 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 605 | 8 | 3 | 5 | 5.0 | CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C(=O)O)c2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1021/jm9601664 | |||
CHEMBL147186 | 46198 | 5 | None | -12 | 2 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 605 | 8 | 3 | 5 | 5.0 | CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C(=O)O)c2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1021/jm9601664 | |||
CHEMBL1172246 | 215360 | 0 | None | 1 | 4 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CC(=O)NCCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc2ccccc2)C(N)=O)NC(=O)[C@H](Cc2cc3ccccc3[nH]2)NC1=O | 10.1016/j.bmcl.2010.05.078 | |||||
10762723 | 103805 | 0 | None | - | 0 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 386 | 4 | 3 | 6 | 3.2 | Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccnc2)c1 | 10.1021/jm970373j | |||
CHEMBL266819 | 103805 | 0 | None | - | 0 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 386 | 4 | 3 | 6 | 3.2 | Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccnc2)c1 | 10.1021/jm970373j | |||
44349324 | 23445 | 0 | None | - | 0 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 455 | 7 | 3 | 4 | 3.4 | O=C(O)CCC(NC(=O)c1cccc(C(F)(F)F)c1)C(=O)NN1CCC2(CCCC2)CC1 | 10.1021/jm00079a003 | |||
CHEMBL124261 | 23445 | 0 | None | - | 0 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 455 | 7 | 3 | 4 | 3.4 | O=C(O)CCC(NC(=O)c1cccc(C(F)(F)F)c1)C(=O)NN1CCC2(CCCC2)CC1 | 10.1021/jm00079a003 | |||
44274261 | 105644 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 782 | 19 | 8 | 7 | 4.1 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)NCCC(=O)NC(Cc1ccccc1)C(N)=O | 10.1021/jm00037a005 | |||
CHEMBL279005 | 105644 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 782 | 19 | 8 | 7 | 4.1 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)NCCC(=O)NC(Cc1ccccc1)C(N)=O | 10.1021/jm00037a005 | |||
44283514 | 177396 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 585 | 12 | 3 | 4 | 6.0 | CC(Cc1c[nH]c2ccccc12)(CN(CCc1ccccc1)C(=O)CCC(=O)O)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1021/jm00086a017 | |||
CHEMBL445094 | 177396 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 585 | 12 | 3 | 4 | 6.0 | CC(Cc1c[nH]c2ccccc12)(CN(CCc1ccccc1)C(=O)CCC(=O)O)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1021/jm00086a017 | |||
11442807 | 84064 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 471 | 9 | 4 | 4 | 3.2 | CC(=O)N/C(=C/c1ccccc1)C(=O)Nc1ccccc1C(=O)NC(Cc1ccccc1)C(=O)O | 10.1021/jm051050n | |||
CHEMBL208171 | 84064 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 471 | 9 | 4 | 4 | 3.2 | CC(=O)N/C(=C/c1ccccc1)C(=O)Nc1ccccc1C(=O)NC(Cc1ccccc1)C(=O)O | 10.1021/jm051050n | |||
45481637 | 205121 | 0 | None | - | 0 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 471 | 10 | 4 | 4 | 3.2 | O=C(CC(=O)Nc1ccccc1C(=O)NC(Cc1ccccc1)C(=O)O)N/C=C/c1ccccc1 | 10.1016/j.bmc.2009.05.067 | |||
CHEMBL576347 | 205121 | 0 | None | - | 0 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 471 | 10 | 4 | 4 | 3.2 | O=C(CC(=O)Nc1ccccc1C(=O)NC(Cc1ccccc1)C(=O)O)N/C=C/c1ccccc1 | 10.1016/j.bmc.2009.05.067 | |||
51353551 | 24906 | 16 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 605 | 8 | 3 | 5 | 5.0 | CC(C)N(C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(C(=O)O)c2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1016/j.bmcl.2015.03.051 | |||
CHEMBL1269257 | 24906 | 16 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 605 | 8 | 3 | 5 | 5.0 | CC(C)N(C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(C(=O)O)c2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1016/j.bmcl.2015.03.051 | |||
10649606 | 56390 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 519 | 6 | 3 | 4 | 4.5 | O=C(CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)Nc1ccccc1 | 10.1016/j.bmcl.2015.03.051 | |||
CHEMBL156605 | 56390 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 519 | 6 | 3 | 4 | 4.5 | O=C(CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)Nc1ccccc1 | 10.1016/j.bmcl.2015.03.051 | |||
10817241 | 113899 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 591 | 8 | 1 | 5 | 5.6 | COc1ccc(N(C(=O)CN2C(=O)C(Cc3[nH]nc4c3CCCC4)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm970265x | |||
CHEMBL316077 | 113899 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 591 | 8 | 1 | 5 | 5.6 | COc1ccc(N(C(=O)CN2C(=O)C(Cc3[nH]nc4c3CCCC4)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm970265x | |||
44381758 | 18502 | 0 | None | - | 0 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 565 | 9 | 2 | 5 | 3.4 | CN1CCN(CCNC(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCC3)CC2)CC1 | 10.1016/S0960-894X(00)80681-2 | |||
CHEMBL1181391 | 18502 | 0 | None | - | 0 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 565 | 9 | 2 | 5 | 3.4 | CN1CCN(CCNC(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCC3)CC2)CC1 | 10.1016/S0960-894X(00)80681-2 | |||
CHEMBL169440 | 18502 | 0 | None | - | 0 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 565 | 9 | 2 | 5 | 3.4 | CN1CCN(CCNC(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCC3)CC2)CC1 | 10.1016/S0960-894X(00)80681-2 | |||
44458096 | 91824 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 388 | 5 | 2 | 3 | 2.7 | O=C(N[C@@H]1C(=O)N(Cc2ccccc2)C[C@@H]1C(=O)O)c1ccc2ccccc2c1 | 10.1016/S0960-894X(00)80224-3 | |||
CHEMBL22417 | 91824 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 388 | 5 | 2 | 3 | 2.7 | O=C(N[C@@H]1C(=O)N(Cc2ccccc2)C[C@@H]1C(=O)O)c1ccc2ccccc2c1 | 10.1016/S0960-894X(00)80224-3 | |||
10009526 | 117280 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 655 | 6 | 3 | 7 | 4.6 | O=C(Nc1cccc(-c2nn[nH]n2)c1)NC1N=C(c2ccccc2F)c2cccc(Cl)c2N(CC(=O)N2CC3CCC(CC3)C2)C1=O | 10.1016/s0960-894x(98)00237-6 | |||
CHEMBL32492 | 117280 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 655 | 6 | 3 | 7 | 4.6 | O=C(Nc1cccc(-c2nn[nH]n2)c1)NC1N=C(c2ccccc2F)c2cccc(Cl)c2N(CC(=O)N2CC3CCC(CC3)C2)C1=O | 10.1016/s0960-894x(98)00237-6 | |||
54580296 | 68690 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 515 | 5 | 0 | 6 | 5.6 | COc1ccc(-c2cnc(C(=O)N3CCN(c4cc5ccccc5cn4)CC3)nc2-c2ccc(C)cc2)cc1 | 10.1016/j.bmcl.2011.03.069 | |||
CHEMBL1774035 | 68690 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 515 | 5 | 0 | 6 | 5.6 | COc1ccc(-c2cnc(C(=O)N3CCN(c4cc5ccccc5cn4)CC3)nc2-c2ccc(C)cc2)cc1 | 10.1016/j.bmcl.2011.03.069 | |||
10418081 | 117149 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 840 | 23 | 9 | 8 | 2.4 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00028a015 | |||
CHEMBL324219 | 117149 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 840 | 23 | 9 | 8 | 2.4 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00028a015 | |||
44293998 | 195203 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 609 | 6 | 2 | 5 | 5.3 | CC(=O)c1cccc(NC(=O)NC2N=C(c3ccccc3F)c3cccc(C)c3N(CC(=O)N3CC4CCC(CC4)C3)C2=O)c1 | 10.1016/S0960-894X(96)00609-9 | |||
CHEMBL50215 | 195203 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 609 | 6 | 2 | 5 | 5.3 | CC(=O)c1cccc(NC(=O)NC2N=C(c3ccccc3F)c3cccc(C)c3N(CC(=O)N3CC4CCC(CC4)C3)C2=O)c1 | 10.1016/S0960-894X(96)00609-9 | |||
90663995 | 113601 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 919 | 23 | 9 | 11 | 2.4 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(OS(=O)(=O)O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
CHEMBL3144564 | 113601 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 919 | 23 | 9 | 11 | 2.4 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(OS(=O)(=O)O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
10769902 | 213324 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 601 | 8 | 1 | 5 | 6.3 | COc1ccc(N(C(=O)CN2C(=O)C(C)(Cc3n[nH]c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm960249k | |||
CHEMBL88629 | 213324 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 601 | 8 | 1 | 5 | 6.3 | COc1ccc(N(C(=O)CN2C(=O)C(C)(Cc3n[nH]c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm960249k | |||
10769902 | 213324 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 601 | 8 | 1 | 5 | 6.3 | COc1ccc(N(C(=O)CN2C(=O)C(C)(Cc3n[nH]c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm970265x | |||
CHEMBL88629 | 213324 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 601 | 8 | 1 | 5 | 6.3 | COc1ccc(N(C(=O)CN2C(=O)C(C)(Cc3n[nH]c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm970265x | |||
10555804 | 118375 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 616 | 9 | 1 | 5 | 6.3 | COc1ccc(N(C(=O)CN2C(=O)C(Cc3c[nH]c4ccccc34)(OC)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm970265x | |||
CHEMBL328285 | 118375 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 616 | 9 | 1 | 5 | 6.3 | COc1ccc(N(C(=O)CN2C(=O)C(Cc3c[nH]c4ccccc34)(OC)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm970265x | |||
11114520 | 122229 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 575 | 7 | 3 | 5 | 4.9 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)N(Cc3ccccc3)C(=S)C[C@H]12 | 10.1021/jm010898i | |||
CHEMBL3350849 | 122229 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 575 | 7 | 3 | 5 | 4.9 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)N(Cc3ccccc3)C(=S)C[C@H]12 | 10.1021/jm010898i | |||
19766167 | 66009 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 420 | 4 | 2 | 3 | 3.1 | Cc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 | 10.1016/S0960-894X(00)80683-6 | |||
CHEMBL170293 | 66009 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 420 | 4 | 2 | 3 | 3.1 | Cc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 | 10.1016/S0960-894X(00)80683-6 | |||
44381577 | 103411 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 840 | 23 | 10 | 10 | 2.9 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(O)cc1)C(=O)N[C@H](CNN[C@@H](Cc1ccccc1)C(N)=O)CC(=O)O | 10.1016/S0960-894X(00)80680-0 | |||
CHEMBL263525 | 103411 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 840 | 23 | 10 | 10 | 2.9 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(O)cc1)C(=O)N[C@H](CNN[C@@H](Cc1ccccc1)C(N)=O)CC(=O)O | 10.1016/S0960-894X(00)80680-0 | |||
44330731 | 215023 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 946 | 25 | 9 | 11 | 0.6 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CC[C@H](NC(=O)CCc2ccc(OS(=O)(=O)O)cc2)C1=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00094a001 | |||
CHEMBL98720 | 215023 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 946 | 25 | 9 | 11 | 0.6 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CC[C@H](NC(=O)CCc2ccc(OS(=O)(=O)O)cc2)C1=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00094a001 | |||
10369805 | 107328 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 532 | 5 | 3 | 3 | 5.6 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2c1ccccc1 | 10.1021/jm00048a015 | |||
CHEMBL291458 | 107328 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 532 | 5 | 3 | 3 | 5.6 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2c1ccccc1 | 10.1021/jm00048a015 | |||
10073082 | 31909 | 2 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 462 | 3 | 2 | 3 | 4.4 | CN1C(=O)C(NC(=O)Nc2ccc(Br)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL134750 | 31909 | 2 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 462 | 3 | 2 | 3 | 4.4 | CN1C(=O)C(NC(=O)Nc2ccc(Br)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
44578530 | 195465 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 556 | 5 | 0 | 5 | 6.9 | Cc1ccc(-c2nc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)cn2-c2cccc(OC(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2008.06.057 | |||
CHEMBL504024 | 195465 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 556 | 5 | 0 | 5 | 6.9 | Cc1ccc(-c2nc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)cn2-c2cccc(OC(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2008.06.057 | |||
90663980 | 113587 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 891 | 21 | 8 | 8 | 4.6 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(Cl)cc1Cl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
CHEMBL3144549 | 113587 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 891 | 21 | 8 | 8 | 4.6 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(Cl)cc1Cl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
44301036 | 205483 | 0 | None | - | 0 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 695 | 8 | 4 | 6 | 5.4 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)NS(=O)(=O)c3ccccc3C)c1)C[C@@H]2c1ccccc1 | 10.1016/0960-894X(95)00327-P | |||
CHEMBL58154 | 205483 | 0 | None | - | 0 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 695 | 8 | 4 | 6 | 5.4 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)NS(=O)(=O)c3ccccc3C)c1)C[C@@H]2c1ccccc1 | 10.1016/0960-894X(95)00327-P | |||
44300864 | 208698 | 0 | None | - | 0 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 681 | 8 | 4 | 6 | 5.1 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)NS(=O)(=O)c3ccccc3)c1)C[C@@H]2c1ccccc1 | 10.1016/0960-894X(95)00327-P | |||
CHEMBL60754 | 208698 | 0 | None | - | 0 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 681 | 8 | 4 | 6 | 5.1 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)NS(=O)(=O)c3ccccc3)c1)C[C@@H]2c1ccccc1 | 10.1016/0960-894X(95)00327-P | |||
367892 | 16304 | 1 | None | - | 0 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 429 | 14 | 3 | 3 | 4.3 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1cc2ccccc2[nH]1 | 10.1021/jm00124a003 | |||
CHEMBL112222 | 16304 | 1 | None | - | 0 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 429 | 14 | 3 | 3 | 4.3 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1cc2ccccc2[nH]1 | 10.1021/jm00124a003 | |||
44349027 | 23598 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 438 | 7 | 3 | 5 | 2.9 | O=C(O)CCC(NC(=O)c1cnc2ccccc2c1)C(=O)NN1CCC2(CCCC2)CC1 | 10.1021/jm00079a003 | |||
CHEMBL124732 | 23598 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 438 | 7 | 3 | 5 | 2.9 | O=C(O)CCC(NC(=O)c1cnc2ccccc2c1)C(=O)NN1CCC2(CCCC2)CC1 | 10.1021/jm00079a003 | |||
44349083 | 124841 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 455 | 7 | 3 | 4 | 3.6 | O=C(O)CCC(NC(=O)c1ccc(Cl)c(Cl)c1)C(=O)NN1CCC2(CCCC2)CC1 | 10.1021/jm00079a003 | |||
CHEMBL340463 | 124841 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 455 | 7 | 3 | 4 | 3.6 | O=C(O)CCC(NC(=O)c1ccc(Cl)c(Cl)c1)C(=O)NN1CCC2(CCCC2)CC1 | 10.1021/jm00079a003 | |||
44336486 | 116136 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 669 | 8 | 2 | 6 | 6.5 | CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C3(C(F)(F)F)N=N3)c2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1016/s0960-894x(98)00548-4 | |||
CHEMBL321915 | 116136 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 669 | 8 | 2 | 6 | 6.5 | CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C3(C(F)(F)F)N=N3)c2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1016/s0960-894x(98)00548-4 | |||
73349789 | 112914 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 629 | 12 | 6 | 6 | 4.3 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCC(=O)NO)c1ccccc1 | 10.1021/jm00092a007 | |||
CHEMBL313499 | 112914 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 629 | 12 | 6 | 6 | 4.3 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCC(=O)NO)c1ccccc1 | 10.1021/jm00092a007 | |||
73346724 | 212867 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 681 | 13 | 5 | 9 | 5.0 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCC(=O)NC1N=NN=N1)c1ccccc1 | 10.1021/jm00092a007 | |||
CHEMBL85607 | 212867 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 681 | 13 | 5 | 9 | 5.0 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCC(=O)NC1N=NN=N1)c1ccccc1 | 10.1021/jm00092a007 | |||
44311923 | 211280 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 421 | 4 | 2 | 3 | 4.0 | O=C(Cc1ccc(Cl)cc1)NC1N=C(c2ccccc2F)c2ccccc2NC1=O | 10.1021/jm00120a002 | |||
CHEMBL72570 | 211280 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 421 | 4 | 2 | 3 | 4.0 | O=C(Cc1ccc(Cl)cc1)NC1N=C(c2ccccc2F)c2ccccc2NC1=O | 10.1021/jm00120a002 | |||
14802536 | 164110 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 628 | 13 | 5 | 5 | 5.2 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NC[C@H](NC(=O)CCCC(=O)O)c1ccccc1 | 10.1021/jm00105a062 | |||
CHEMBL2112694 | 164110 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 628 | 13 | 5 | 5 | 5.2 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NC[C@H](NC(=O)CCCC(=O)O)c1ccccc1 | 10.1021/jm00105a062 | |||
CHEMBL407753 | 164110 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 628 | 13 | 5 | 5 | 5.2 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NC[C@H](NC(=O)CCCC(=O)O)c1ccccc1 | 10.1021/jm00105a062 | |||
44356799 | 32836 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 452 | 3 | 2 | 3 | 4.7 | CN1C(=O)C(NC(=O)Nc2ccc(C(F)(F)F)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL135538 | 32836 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 452 | 3 | 2 | 3 | 4.7 | CN1C(=O)C(NC(=O)Nc2ccc(C(F)(F)F)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
10392870 | 35873 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 552 | 7 | 2 | 5 | 5.4 | O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)OCc2ccccc2)C1=O | 10.1021/jm00078a018 | |||
CHEMBL138122 | 35873 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 552 | 7 | 2 | 5 | 5.4 | O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)OCc2ccccc2)C1=O | 10.1021/jm00078a018 | |||
44356710 | 123389 | 8 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 426 | 4 | 2 | 4 | 3.9 | CC(=O)c1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00078a018 | |||
CHEMBL336765 | 123389 | 8 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 426 | 4 | 2 | 4 | 3.9 | CC(=O)c1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00078a018 | |||
CHEMBL285995 | 106668 | 0 | None | - | 1 | Mouse | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 741 | 16 | 6 | 11 | 4.5 | CN1C(=O)[C@H](NC(=O)Nc2cccc(CCOC(=O)NCCCNCCSCc3csc(C=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00249-1 | |||
44280225 | 106739 | 0 | None | - | 1 | Mouse | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 743 | 15 | 4 | 7 | 5.4 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
CHEMBL286475 | 106739 | 0 | None | - | 1 | Mouse | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 743 | 15 | 4 | 7 | 5.4 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
44334278 | 11472 | 0 | None | - | 0 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 515 | 9 | 2 | 4 | 5.5 | Cc1cccc(NC(=O)N[C@H](CSCc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
CHEMBL103457 | 11472 | 0 | None | - | 0 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 515 | 9 | 2 | 4 | 5.5 | Cc1cccc(NC(=O)N[C@H](CSCc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
44334224 | 11827 | 0 | None | - | 0 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 480 | 7 | 2 | 5 | 3.3 | Cc1cccc(NC(=O)N[C@H](COC(=O)N(C)C)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
CHEMBL105303 | 11827 | 0 | None | - | 0 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 480 | 7 | 2 | 5 | 3.3 | Cc1cccc(NC(=O)N[C@H](COC(=O)N(C)C)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
44334176 | 11842 | 0 | None | - | 0 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 527 | 9 | 2 | 5 | 4.7 | Cc1cccc(NC(=O)N[C@H](CC(=O)OCc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
CHEMBL105404 | 11842 | 0 | None | - | 0 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 527 | 9 | 2 | 5 | 4.7 | Cc1cccc(NC(=O)N[C@H](CC(=O)OCc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
44334438 | 116032 | 0 | None | - | 0 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 513 | 9 | 2 | 4 | 5.2 | Cc1cccc(NC(=O)N[C@@H](C(=O)N2CCC(C(=O)c3ccccc3)CC2)[C@@H](C)OCc2ccccc2)c1 | 10.1016/0960-894X(95)00537-3 | |||
CHEMBL321800 | 116032 | 0 | None | - | 0 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 513 | 9 | 2 | 4 | 5.2 | Cc1cccc(NC(=O)N[C@@H](C(=O)N2CCC(C(=O)c3ccccc3)CC2)[C@@H](C)OCc2ccccc2)c1 | 10.1016/0960-894X(95)00537-3 | |||
44334270 | 170266 | 0 | None | - | 0 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 437 | 8 | 2 | 4 | 3.5 | CC(=O)C1CCN(C(=O)[C@@H](COCc2ccccc2)NC(=O)Nc2cccc(C)c2)CC1 | 10.1016/0960-894X(95)00537-3 | |||
CHEMBL420098 | 170266 | 0 | None | - | 0 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 437 | 8 | 2 | 4 | 3.5 | CC(=O)C1CCN(C(=O)[C@@H](COCc2ccccc2)NC(=O)Nc2cccc(C)c2)CC1 | 10.1016/0960-894X(95)00537-3 | |||
44366601 | 49200 | 11 | None | - | 0 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 323 | 4 | 0 | 3 | 3.5 | O=C1CCN(C(=O)OCc2ccccc2)CC1Cc1ccccc1 | 10.1016/0960-894X(94)80030-8 | |||
CHEMBL149905 | 49200 | 11 | None | - | 0 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 323 | 4 | 0 | 3 | 3.5 | O=C1CCN(C(=O)OCc2ccccc2)CC1Cc1ccccc1 | 10.1016/0960-894X(94)80030-8 | |||
44382487 | 172415 | 0 | None | - | 0 | Mouse | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 518 | 10 | 4 | 4 | 2.7 | CC(C)C[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N1C[C@H](Cc2ccccc2)NC(=O)[C@@H]1CC(=O)O | 10.1016/S0960-894X(01)80253-5 | |||
CHEMBL424370 | 172415 | 0 | None | - | 0 | Mouse | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 518 | 10 | 4 | 4 | 2.7 | CC(C)C[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N1C[C@H](Cc2ccccc2)NC(=O)[C@@H]1CC(=O)O | 10.1016/S0960-894X(01)80253-5 | |||
44349023 | 23126 | 0 | None | - | 0 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 384 | 8 | 3 | 3 | 3.4 | CC(C)(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1ccc2ccccc2c1 | 10.1021/jm00079a003 | |||
CHEMBL122922 | 23126 | 0 | None | - | 0 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 384 | 8 | 3 | 3 | 3.4 | CC(C)(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1ccc2ccccc2c1 | 10.1021/jm00079a003 | |||
15167808 | 211328 | 0 | None | - | 0 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 4.1 | CN(C(=O)c1cc2ccccc2[nH]1)C1N=C(c2ccccc2)c2ccccc2NC1=O | 10.1021/jm00120a002 | |||
CHEMBL72894 | 211328 | 0 | None | - | 0 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 4.1 | CN(C(=O)c1cc2ccccc2[nH]1)C1N=C(c2ccccc2)c2ccccc2NC1=O | 10.1021/jm00120a002 | |||
19766230 | 37497 | 0 | None | - | 0 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 499 | 6 | 1 | 4 | 4.7 | COC(C(=O)NCC1CN=C(c2ccccc2F)c2ccccc2N1C)(c1ccccc1)C(F)(F)F | 10.1021/jm00163a069 | |||
CHEMBL139520 | 37497 | 0 | None | - | 0 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 499 | 6 | 1 | 4 | 4.7 | COC(C(=O)NCC1CN=C(c2ccccc2F)c2ccccc2N1C)(c1ccccc1)C(F)(F)F | 10.1021/jm00163a069 | |||
45481627 | 203475 | 0 | None | - | 0 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 419 | 7 | 4 | 4 | 2.7 | O=C(Nc1ccccc1C(=O)NC(Cc1ccccc1)C(=O)O)C1=CC2CCCC2N1 | 10.1016/j.bmc.2009.05.067 | |||
CHEMBL564796 | 203475 | 0 | None | - | 0 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 419 | 7 | 4 | 4 | 2.7 | O=C(Nc1ccccc1C(=O)NC(Cc1ccccc1)C(=O)O)C1=CC2CCCC2N1 | 10.1016/j.bmc.2009.05.067 | |||
51353551 | 24906 | 16 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 605 | 8 | 3 | 5 | 5.0 | CC(C)N(C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(C(=O)O)c2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1016/j.bmcl.2010.08.115 | |||
CHEMBL1269257 | 24906 | 16 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 605 | 8 | 3 | 5 | 5.0 | CC(C)N(C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(C(=O)O)c2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1016/j.bmcl.2010.08.115 | |||
16100406 | 89999 | 0 | None | -33 | 4 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 1132 | 28 | 13 | 13 | 1.7 | CCCC[C@@H](NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1cc2ccccc2[nH]1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm061268p | |||
CHEMBL218600 | 89999 | 0 | None | -33 | 4 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 1132 | 28 | 13 | 13 | 1.7 | CCCC[C@@H](NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1cc2ccccc2[nH]1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm061268p | |||
10531224 | 174780 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 575 | 7 | 2 | 4 | 5.7 | CC(C)N(C(=O)CN1C(=O)C(C)(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1021/jm960205b | |||
CHEMBL432015 | 174780 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 575 | 7 | 2 | 4 | 5.7 | CC(C)N(C(=O)CN1C(=O)C(C)(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1021/jm960205b | |||
10531224 | 174780 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 575 | 7 | 2 | 4 | 5.7 | CC(C)N(C(=O)CN1C(=O)C(C)(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1021/acs.jmedchem.0c00829 | |||
CHEMBL432015 | 174780 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 575 | 7 | 2 | 4 | 5.7 | CC(C)N(C(=O)CN1C(=O)C(C)(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1021/acs.jmedchem.0c00829 | |||
11775012 | 204891 | 0 | None | - | 0 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 439 | 7 | 3 | 4 | 3.9 | O=C(NC(Cc1ccccc1)C(=O)O)c1ccccc1NC(=O)c1nccc2ccccc12 | 10.1016/j.bmc.2009.05.067 | |||
CHEMBL574530 | 204891 | 0 | None | - | 0 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 439 | 7 | 3 | 4 | 3.9 | O=C(NC(Cc1ccccc1)C(=O)O)c1ccccc1NC(=O)c1nccc2ccccc12 | 10.1016/j.bmc.2009.05.067 | |||
44287088 | 106987 | 0 | None | - | 0 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 838 | 22 | 7 | 7 | 5.6 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)NCCCCCC(=O)N(C)C(Cc1ccccc1)C(N)=O | 10.1021/jm00037a005 | |||
CHEMBL288373 | 106987 | 0 | None | - | 0 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 838 | 22 | 7 | 7 | 5.6 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)NCCCCCC(=O)N(C)C(Cc1ccccc1)C(N)=O | 10.1021/jm00037a005 | |||
10649606 | 56390 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 519 | 6 | 3 | 4 | 4.5 | O=C(CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)Nc1ccccc1 | 10.1016/j.bmcl.2015.03.051 | |||
CHEMBL156605 | 56390 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 519 | 6 | 3 | 4 | 4.5 | O=C(CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)Nc1ccccc1 | 10.1016/j.bmcl.2015.03.051 | |||
44396785 | 73952 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 530 | 7 | 2 | 5 | 4.6 | C[C@H]1C(=O)N(Cc2ccccc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC(C)(C)C)C12 | 10.1021/jm0498755 | |||
CHEMBL187732 | 73952 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 530 | 7 | 2 | 5 | 4.6 | C[C@H]1C(=O)N(Cc2ccccc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC(C)(C)C)C12 | 10.1021/jm0498755 | |||
44303669 | 175068 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 573 | 10 | 4 | 5 | 3.9 | O=C(O)CCC(=O)N[C@@H](CNC(=O)C1(NC(=O)OC2C3CC4CC(C3)CC2C4)Cc2ccccc2C1)c1ccccc1 | 10.1016/S0960-894X(97)00356-9 | |||
CHEMBL434020 | 175068 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 573 | 10 | 4 | 5 | 3.9 | O=C(O)CCC(=O)N[C@@H](CNC(=O)C1(NC(=O)OC2C3CC4CC(C3)CC2C4)Cc2ccccc2C1)c1ccccc1 | 10.1016/S0960-894X(97)00356-9 | |||
44349069 | 124837 | 0 | None | - | 0 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 455 | 7 | 3 | 4 | 3.6 | O=C(O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)NN1CCC2(CCCC2)CC1 | 10.1021/jm00079a003 | |||
CHEMBL340413 | 124837 | 0 | None | - | 0 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 455 | 7 | 3 | 4 | 3.6 | O=C(O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)NN1CCC2(CCCC2)CC1 | 10.1021/jm00079a003 | |||
65987 | 106353 | 13 | None | - | 0 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 440 | 6 | 2 | 3 | 4.1 | O=C(O)CC[C@@H](NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1016/S0960-894X(00)80681-2 | |||
CHEMBL283820 | 106353 | 13 | None | - | 0 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 440 | 6 | 2 | 3 | 4.1 | O=C(O)CC[C@@H](NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1016/S0960-894X(00)80681-2 | |||
65987 | 106353 | 13 | None | - | 0 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 440 | 6 | 2 | 3 | 4.1 | O=C(O)CC[C@@H](NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
CHEMBL283820 | 106353 | 13 | None | - | 0 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 440 | 6 | 2 | 3 | 4.1 | O=C(O)CC[C@@H](NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
15281185 | 56228 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 484 | 5 | 2 | 6 | 3.7 | Cc1cccc(NC(=O)NC2N=C(c3cnccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1016/0960-894X(95)00557-A | |||
CHEMBL156484 | 56228 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 484 | 5 | 2 | 6 | 3.7 | Cc1cccc(NC(=O)NC2N=C(c3cnccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1016/0960-894X(95)00557-A | |||
10555164 | 119531 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 575 | 7 | 1 | 4 | 6.0 | CC(C)N(C(=O)CN1C(=O)C(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc21)c1ccc(F)cc1 | 10.1021/jm970265x | |||
CHEMBL330521 | 119531 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 575 | 7 | 1 | 4 | 6.0 | CC(C)N(C(=O)CN1C(=O)C(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc21)c1ccc(F)cc1 | 10.1021/jm970265x | |||
44359376 | 126137 | 1 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 493 | 6 | 4 | 4 | 4.4 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1CCCCC1O | 10.1021/jm970065l | |||
CHEMBL344380 | 126137 | 1 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 493 | 6 | 4 | 4 | 4.4 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1CCCCC1O | 10.1021/jm970065l | |||
10647112 | 170202 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 447 | 3 | 3 | 4 | 4.1 | Cc1cccc(NC(=O)N[C@@H]2N=C([C@H]3CCC(C)(C)CCN3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm9608523 | |||
CHEMBL419663 | 170202 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 447 | 3 | 3 | 4 | 4.1 | Cc1cccc(NC(=O)N[C@@H]2N=C([C@H]3CCC(C)(C)CCN3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm9608523 | |||
44211353 | 65827 | 0 | None | - | 0 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 552 | 9 | 2 | 5 | 3.5 | O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NCCN1CCOCC1 | 10.1016/S0960-894X(00)80681-2 | |||
CHEMBL169453 | 65827 | 0 | None | - | 0 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 552 | 9 | 2 | 5 | 3.5 | O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NCCN1CCOCC1 | 10.1016/S0960-894X(00)80681-2 | |||
10484212 | 106655 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 635 | 6 | 3 | 7 | 4.3 | Cc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(-c3nn[nH]n3)c1)N=C2c1ccccc1F | 10.1016/s0960-894x(98)00237-6 | |||
CHEMBL285921 | 106655 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 635 | 6 | 3 | 7 | 4.3 | Cc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(-c3nn[nH]n3)c1)N=C2c1ccccc1F | 10.1016/s0960-894x(98)00237-6 | |||
CHEMBL355608 | 218518 | 0 | None | - | 0 | Mouse | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1)C(=O)N1CC(=O)N[C@H](Cc2ccccc2)C1 | 10.1016/S0960-894X(01)80253-5 | |||||
CHEMBL3142924 | 217917 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | None | None | None | COc1ccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 | 10.1021/jm960509y | |||||
10484212 | 106655 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 635 | 6 | 3 | 7 | 4.3 | Cc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(-c3nn[nH]n3)c1)N=C2c1ccccc1F | 10.1016/S0960-894X(96)00609-9 | |||
CHEMBL285921 | 106655 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 635 | 6 | 3 | 7 | 4.3 | Cc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(-c3nn[nH]n3)c1)N=C2c1ccccc1F | 10.1016/S0960-894X(96)00609-9 | |||
9823890 | 33707 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 428 | 4 | 3 | 4 | 3.3 | CN1C(=O)C(NC(=O)Nc2cccc(C(=O)O)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL136412 | 33707 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 428 | 4 | 3 | 4 | 3.3 | CN1C(=O)C(NC(=O)Nc2cccc(C(=O)O)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
44578251 | 189211 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 486 | 5 | 0 | 5 | 5.5 | COc1cccc(-n2cc(C(=O)N3CCN(c4cccc(Cl)c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
CHEMBL478604 | 189211 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 486 | 5 | 0 | 5 | 5.5 | COc1cccc(-n2cc(C(=O)N3CCN(c4cccc(Cl)c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
14991568 | 107487 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 847 | 20 | 8 | 8 | 4.0 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1ccc2ccccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
CHEMBL292519 | 107487 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 847 | 20 | 8 | 8 | 4.0 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1ccc2ccccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
14991575 | 107561 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 852 | 20 | 10 | 9 | 3.0 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1cc2cc(O)ccc2[nH]1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
CHEMBL293026 | 107561 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 852 | 20 | 10 | 9 | 3.0 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1cc2cc(O)ccc2[nH]1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
CHEMBL434674 | 220439 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | None | None | None | CN[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1C)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00031a013 | |||||
44336539 | 11916 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 563 | 7 | 2 | 5 | 4.6 | COc1ccc(N(C)C(=O)CN2C(=O)C(NC(=O)Nc3ccccc3)C(=O)N(c3ccccc3)c3ccccc32)cc1 | 10.1016/j.bmcl.2015.03.051 | |||
CHEMBL105775 | 11916 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 563 | 7 | 2 | 5 | 4.6 | COc1ccc(N(C)C(=O)CN2C(=O)C(NC(=O)Nc3ccccc3)C(=O)N(c3ccccc3)c3ccccc32)cc1 | 10.1016/j.bmcl.2015.03.051 | |||
10675328 | 118282 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 617 | 9 | 1 | 6 | 5.7 | COc1ccc(N(C(=O)CN2C(=O)C(Cc3n[nH]c4ccccc34)(OC)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm970265x | |||
CHEMBL327815 | 118282 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 617 | 9 | 1 | 6 | 5.7 | COc1ccc(N(C(=O)CN2C(=O)C(Cc3n[nH]c4ccccc34)(OC)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm970265x | |||
46235271 | 80423 | 2 | None | - | 2 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 649 | 7 | 1 | 6 | 6.7 | Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1016/j.bmcl.2012.02.049 | |||
CHEMBL2017835 | 80423 | 2 | None | - | 2 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 649 | 7 | 1 | 6 | 6.7 | Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1016/j.bmcl.2012.02.049 | |||
44210424 | 125996 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 423 | 4 | 2 | 4 | 3.8 | Cc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)OC(C)(C)C)C2=O)c1 | 10.1016/S0960-894X(00)80683-6 | |||
CHEMBL34335 | 125996 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 423 | 4 | 2 | 4 | 3.8 | Cc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)OC(C)(C)C)C2=O)c1 | 10.1016/S0960-894X(00)80683-6 | |||
9868877 | 214445 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 460 | 8 | 2 | 4 | 3.8 | COc1cccc(N(CC(=O)N(C)c2ccccc2)C(=O)CNC(=O)Nc2cccc(C)c2)c1 | 10.1021/jm970373j | |||
CHEMBL9534 | 214445 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 460 | 8 | 2 | 4 | 3.8 | COc1cccc(N(CC(=O)N(C)c2ccccc2)C(=O)CNC(=O)Nc2cccc(C)c2)c1 | 10.1021/jm970373j | |||
10440992 | 168075 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 990 | 28 | 9 | 11 | 1.8 | CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00094a001 | |||
CHEMBL412238 | 168075 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 990 | 28 | 9 | 11 | 1.8 | CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00094a001 | |||
10440992 | 168075 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 990 | 28 | 9 | 11 | 1.8 | CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00031a013 | |||
CHEMBL412238 | 168075 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 990 | 28 | 9 | 11 | 1.8 | CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00031a013 | |||
44382735 | 127541 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 646 | 13 | 4 | 4 | 6.1 | O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1)NCCc1ccccc1 | 10.1016/S0960-894X(00)80687-3 | |||
CHEMBL355275 | 127541 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 646 | 13 | 4 | 4 | 6.1 | O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1)NCCc1ccccc1 | 10.1016/S0960-894X(00)80687-3 | |||
CHEMBL2079550 | 215972 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1ccc(C(F)(F)C(=O)O)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00107a037 | |||||
19910130 | 126569 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 439 | 14 | 3 | 3 | 4.9 | CCCCCN(CCCCC)C(=O)C(CCC(=O)O)NC(=O)Nc1ccc(Cl)cc1 | 10.1021/jm00164a020 | |||
CHEMBL348168 | 126569 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 439 | 14 | 3 | 3 | 4.9 | CCCCCN(CCCCC)C(=O)C(CCC(=O)O)NC(=O)Nc1ccc(Cl)cc1 | 10.1021/jm00164a020 | |||
44578562 | 188313 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 530 | 4 | 0 | 6 | 5.7 | Cc1ccc(-c2nc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)cn2-c2cccc3c2OCCO3)cc1 | 10.1016/j.bmcl.2008.06.057 | |||
CHEMBL476519 | 188313 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 530 | 4 | 0 | 6 | 5.7 | Cc1ccc(-c2nc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)cn2-c2cccc3c2OCCO3)cc1 | 10.1016/j.bmcl.2008.06.057 | |||
14991540 | 113579 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 855 | 23 | 8 | 9 | 3.2 | COc1ccc(CCC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 | 10.1021/jm00089a010 | |||
CHEMBL3144540 | 113579 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 855 | 23 | 8 | 9 | 3.2 | COc1ccc(CCC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 | 10.1021/jm00089a010 | |||
90663993 | 113599 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 901 | 21 | 8 | 8 | 4.0 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(Br)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
CHEMBL3144562 | 113599 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 901 | 21 | 8 | 8 | 4.0 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(Br)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
9828961 | 174765 | 0 | None | - | 0 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 548 | 6 | 4 | 4 | 5.2 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)O)c1)C[C@@H]2C1CCCCC1 | 10.1016/0960-894X(95)00327-P | |||
CHEMBL431919 | 174765 | 0 | None | - | 0 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 548 | 6 | 4 | 4 | 5.2 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)O)c1)C[C@@H]2C1CCCCC1 | 10.1016/0960-894X(95)00327-P | |||
44382709 | 65991 | 0 | None | - | 0 | Mouse | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 504 | 10 | 4 | 4 | 2.9 | CCCC[C@H](NC(=O)c1c[nH]c2ccccc12)C(=O)N1C[C@H](Cc2ccccc2)NC(=O)[C@@H]1CC(=O)O | 10.1016/S0960-894X(01)80253-5 | |||
CHEMBL170207 | 65991 | 0 | None | - | 0 | Mouse | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 504 | 10 | 4 | 4 | 2.9 | CCCC[C@H](NC(=O)c1c[nH]c2ccccc12)C(=O)N1C[C@H](Cc2ccccc2)NC(=O)[C@@H]1CC(=O)O | 10.1016/S0960-894X(01)80253-5 | |||
44368454 | 127993 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 549 | 4 | 3 | 7 | 3.5 | CC(C)C[C@]1(C)N[C@H]2N(C1=O)c1ccccc1[C@@]2(O)C[C@@H]1NC(=O)c2ccccc2-n2c1nc1ccccc1c2=O | 10.1021/jm020424z | |||
CHEMBL357749 | 127993 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 549 | 4 | 3 | 7 | 3.5 | CC(C)C[C@]1(C)N[C@H]2N(C1=O)c1ccccc1[C@@]2(O)C[C@@H]1NC(=O)c2ccccc2-n2c1nc1ccccc1c2=O | 10.1021/jm020424z | |||
14208264 | 108886 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 411 | 3 | 2 | 3 | 4.5 | CC(C)(C)c1ccc(C(=O)NC2N=C(c3ccccc3)c3ccccc3NC2=O)cc1 | 10.1021/jm00120a002 | |||
CHEMBL302282 | 108886 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 411 | 3 | 2 | 3 | 4.5 | CC(C)(C)c1ccc(C(=O)NC2N=C(c3ccccc3)c3ccccc3NC2=O)cc1 | 10.1021/jm00120a002 | |||
44382560 | 127095 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 660 | 14 | 4 | 4 | 6.5 | O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1)NCCCc1ccccc1 | 10.1016/S0960-894X(00)80687-3 | |||
CHEMBL352817 | 127095 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 660 | 14 | 4 | 4 | 6.5 | O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1)NCCCc1ccccc1 | 10.1016/S0960-894X(00)80687-3 | |||
44362745 | 39830 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 680 | 12 | 3 | 6 | 5.7 | C[Si](C)(C)CCOC(=O)C[C@@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@@H]2C[C@H](NC(=O)OCc3ccccc3)C(=O)N12 | 10.1016/s0960-894x(98)00677-5 | |||
CHEMBL141655 | 39830 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 680 | 12 | 3 | 6 | 5.7 | C[Si](C)(C)CCOC(=O)C[C@@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@@H]2C[C@H](NC(=O)OCc3ccccc3)C(=O)N12 | 10.1016/s0960-894x(98)00677-5 | |||
10030203 | 32662 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 540 | 6 | 2 | 6 | 2.8 | COc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)N3CCN(C)CC3)C2=O)c1 | 10.1021/jm00078a018 | |||
CHEMBL135371 | 32662 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 540 | 6 | 2 | 6 | 2.8 | COc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)N3CCN(C)CC3)C2=O)c1 | 10.1021/jm00078a018 | |||
44357031 | 35471 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 585 | 8 | 2 | 9 | 3.1 | COC(=O)[C@H]1CCCN1OC(=O)CN1C(=O)C(NC(=O)Nc2cccc(OC)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL137779 | 35471 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 585 | 8 | 2 | 9 | 3.1 | COC(=O)[C@H]1CCCN1OC(=O)CN1C(=O)C(NC(=O)Nc2cccc(OC)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
3035433 | 106244 | 15 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 535 | 4 | 3 | 7 | 3.1 | CC(C)C[C@@H]1N[C@H]2N(C1=O)c1ccccc1[C@@]2(O)C[C@@H]1NC(=O)c2ccccc2-n2c1nc1ccccc1c2=O | 10.1021/np9800102 | |||
CHEMBL283117 | 106244 | 15 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 535 | 4 | 3 | 7 | 3.1 | CC(C)C[C@@H]1N[C@H]2N(C1=O)c1ccccc1[C@@]2(O)C[C@@H]1NC(=O)c2ccccc2-n2c1nc1ccccc1c2=O | 10.1021/np9800102 | |||
44334177 | 116544 | 0 | None | - | 0 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 508 | 7 | 3 | 3 | 5.3 | Cc1cccc(NC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
CHEMBL323127 | 116544 | 0 | None | - | 0 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 508 | 7 | 3 | 3 | 5.3 | Cc1cccc(NC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
9983680 | 170102 | 0 | None | - | 0 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 506 | 7 | 2 | 5 | 3.8 | Cc1cccc(NC(=O)N[C@H](COC(=O)N2CCCC2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
CHEMBL418987 | 170102 | 0 | None | - | 0 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 506 | 7 | 2 | 5 | 3.8 | Cc1cccc(NC(=O)N[C@H](COC(=O)N2CCCC2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
44349185 | 23303 | 0 | None | - | 0 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 421 | 7 | 3 | 4 | 3.0 | O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NN1CCC2(CCCCC2)C1 | 10.1021/jm00079a003 | |||
CHEMBL123720 | 23303 | 0 | None | - | 0 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 421 | 7 | 3 | 4 | 3.0 | O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NN1CCC2(CCCCC2)C1 | 10.1021/jm00079a003 | |||
13953698 | 108686 | 0 | None | - | 0 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 464 | 5 | 1 | 5 | 5.1 | CN(C)Cc1nnc2n1-c1ccccc1C(c1ccccc1F)=N[C@@H]2Cc1c[nH]c2ccccc12 | 10.1021/jm00396a028 | |||
CHEMBL300926 | 108686 | 0 | None | - | 0 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 464 | 5 | 1 | 5 | 5.1 | CN(C)Cc1nnc2n1-c1ccccc1C(c1ccccc1F)=N[C@@H]2Cc1c[nH]c2ccccc12 | 10.1021/jm00396a028 | |||
15614752 | 125527 | 0 | None | - | 0 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 549 | 6 | 3 | 5 | 4.6 | O=C1Nc2ccccc2C(c2ccccc2F)=NC1CNCC1N=C(c2ccccc2F)c2ccccc2NC1=O | 10.1021/jm00163a069 | |||
CHEMBL341815 | 125527 | 0 | None | - | 0 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 549 | 6 | 3 | 5 | 4.6 | O=C1Nc2ccccc2C(c2ccccc2F)=NC1CNCC1N=C(c2ccccc2F)c2ccccc2NC1=O | 10.1021/jm00163a069 | |||
44286977 | 106914 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 782 | 18 | 7 | 7 | 4.1 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N(C)C(Cc1ccccc1)C(N)=O | 10.1021/jm00037a005 | |||
CHEMBL287712 | 106914 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 782 | 18 | 7 | 7 | 4.1 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N(C)C(Cc1ccccc1)C(N)=O | 10.1021/jm00037a005 | |||
14208264 | 108886 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 411 | 3 | 2 | 3 | 4.5 | CC(C)(C)c1ccc(C(=O)NC2N=C(c3ccccc3)c3ccccc3NC2=O)cc1 | 10.1021/jm00047a021 | |||
CHEMBL302282 | 108886 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 411 | 3 | 2 | 3 | 4.5 | CC(C)(C)c1ccc(C(=O)NC2N=C(c3ccccc3)c3ccccc3NC2=O)cc1 | 10.1021/jm00047a021 | |||
10625001 | 35951 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 493 | 7 | 4 | 4 | 4.4 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1(CO)CCCC1 | 10.1021/jm970065l | |||
CHEMBL138190 | 35951 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 493 | 7 | 4 | 4 | 4.4 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1(CO)CCCC1 | 10.1021/jm970065l | |||
73349872 | 95976 | 1 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 616 | 12 | 5 | 5 | 5.2 | CC1(C)[C@H]2CC[C@@]1(C)[C@H](OC(=O)N[C@](C)(Cc1c[nH]c3ccccc13)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1)C2 | 10.1016/S0960-894X(97)00107-8 | |||
CHEMBL2367718 | 95976 | 1 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 616 | 12 | 5 | 5 | 5.2 | CC1(C)[C@H]2CC[C@@]1(C)[C@H](OC(=O)N[C@](C)(Cc1c[nH]c3ccccc13)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1)C2 | 10.1016/S0960-894X(97)00107-8 | |||
CHEMBL2367719 | 95976 | 1 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 616 | 12 | 5 | 5 | 5.2 | CC1(C)[C@H]2CC[C@@]1(C)[C@H](OC(=O)N[C@](C)(Cc1c[nH]c3ccccc13)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1)C2 | 10.1016/S0960-894X(97)00107-8 | |||
44376113 | 126739 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 494 | 6 | 3 | 6 | 3.9 | CC(C)CN1C(=O)[C@@H](NC(=O)Nc2ccc(-c3nn[nH]n3)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00032a003 | |||
CHEMBL349730 | 126739 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 494 | 6 | 3 | 6 | 3.9 | CC(C)CN1C(=O)[C@@H](NC(=O)Nc2ccc(-c3nn[nH]n3)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00032a003 | |||
10369803 | 23354 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 532 | 7 | 3 | 3 | 5.7 | CCC(C)(C)NC(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](c2ccccc2)c2ccccc21 | 10.1021/jm00048a015 | |||
CHEMBL123951 | 23354 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 532 | 7 | 3 | 3 | 5.7 | CCC(C)(C)NC(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](c2ccccc2)c2ccccc21 | 10.1021/jm00048a015 | |||
10481751 | 119868 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 518 | 5 | 3 | 3 | 5.3 | CC(C)(C)NC(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](c2ccccc2)c2ccccc21 | 10.1021/jm00048a015 | |||
CHEMBL331315 | 119868 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 518 | 5 | 3 | 3 | 5.3 | CC(C)(C)NC(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](c2ccccc2)c2ccccc21 | 10.1021/jm00048a015 | |||
11741648 | 33131 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 399 | 3 | 2 | 4 | 3.4 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccncc3N(C)C2=O)c1 | 10.1021/jm00078a018 | |||
CHEMBL135909 | 33131 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 399 | 3 | 2 | 4 | 3.4 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccncc3N(C)C2=O)c1 | 10.1021/jm00078a018 | |||
3452843 | 126303 | 15 | None | - | 10 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 516 | 6 | 2 | 4 | 5.5 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1 | 10.1016/0960-894X(95)00557-A | |||
CHEMBL345686 | 126303 | 15 | None | - | 10 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 516 | 6 | 2 | 4 | 5.5 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1 | 10.1016/0960-894X(95)00557-A | |||
122130 | 10887 | 39 | None | - | 1 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 516 | 6 | 2 | 4 | 5.5 | Cc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccc2)c2c(N(C1=O)CC(=O)c1ccccc1C)cccc2 | 10.1016/0960-894X(95)00556-9 | |||
888 | 10887 | 39 | None | - | 1 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 516 | 6 | 2 | 4 | 5.5 | Cc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccc2)c2c(N(C1=O)CC(=O)c1ccccc1C)cccc2 | 10.1016/0960-894X(95)00556-9 | |||
CHEMBL115121 | 10887 | 39 | None | - | 1 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 516 | 6 | 2 | 4 | 5.5 | Cc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccc2)c2c(N(C1=O)CC(=O)c1ccccc1C)cccc2 | 10.1016/0960-894X(95)00556-9 | |||
122130 | 10887 | 39 | None | - | 1 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 516 | 6 | 2 | 4 | 5.5 | Cc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccc2)c2c(N(C1=O)CC(=O)c1ccccc1C)cccc2 | 10.1021/jm960669+ | |||
888 | 10887 | 39 | None | - | 1 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 516 | 6 | 2 | 4 | 5.5 | Cc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccc2)c2c(N(C1=O)CC(=O)c1ccccc1C)cccc2 | 10.1021/jm960669+ | |||
CHEMBL115121 | 10887 | 39 | None | - | 1 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 516 | 6 | 2 | 4 | 5.5 | Cc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccc2)c2c(N(C1=O)CC(=O)c1ccccc1C)cccc2 | 10.1021/jm960669+ | |||
44283150 | 172024 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 529 | 9 | 3 | 4 | 4.7 | CN(C(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(CO)Cc1ccccc1 | 10.1021/jm00086a017 | |||
CHEMBL422941 | 172024 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 529 | 9 | 3 | 4 | 4.7 | CN(C(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(CO)Cc1ccccc1 | 10.1021/jm00086a017 | |||
15104604 | 116241 | 0 | None | - | 0 | Guinea pig | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 448 | 13 | 2 | 3 | 5.1 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cccnc1 | 10.1021/jm00116a002 | |||
CHEMBL322031 | 116241 | 0 | None | - | 0 | Guinea pig | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 448 | 13 | 2 | 3 | 5.1 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cccnc1 | 10.1021/jm00116a002 | |||
44359338 | 175445 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 489 | 6 | 3 | 3 | 5.3 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1CC2CCC1C2 | 10.1021/jm970065l | |||
CHEMBL436411 | 175445 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 489 | 6 | 3 | 3 | 5.3 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1CC2CCC1C2 | 10.1021/jm970065l | |||
11755707 | 64296 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 500 | 8 | 2 | 7 | 4.7 | CCOC(=O)c1cccc(NC(=O)NCc2nc3ccccc3c(=O)n2-c2cccc(OC(C)C)c2)c1 | 10.1016/S0960-894X(97)00108-X | |||
CHEMBL166168 | 64296 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 500 | 8 | 2 | 7 | 4.7 | CCOC(=O)c1cccc(NC(=O)NCc2nc3ccccc3c(=O)n2-c2cccc(OC(C)C)c2)c1 | 10.1016/S0960-894X(97)00108-X | |||
10345812 | 25422 | 0 | None | - | 0 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 498 | 5 | 3 | 3 | 5.0 | Cc1ccccc1NC(=O)N[C@@H]1C[C@H](c2ccccc2)c2ccccc2N(CC(=O)NC(C)(C)C)C1=O | 10.1021/jm00048a015 | |||
CHEMBL127687 | 25422 | 0 | None | - | 0 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 498 | 5 | 3 | 3 | 5.0 | Cc1ccccc1NC(=O)N[C@@H]1C[C@H](c2ccccc2)c2ccccc2N(CC(=O)NC(C)(C)C)C1=O | 10.1021/jm00048a015 | |||
42636923 | 185610 | 0 | None | - | 0 | Guinea pig | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 393 | 7 | 4 | 3 | 3.6 | CC(C)C[C@@H](NC(=O)c1ccccc1NC(=O)c1cc2ccccc2[nH]1)C(=O)O | 10.1016/j.bmc.2009.02.012 | |||
CHEMBL469341 | 185610 | 0 | None | - | 0 | Guinea pig | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 393 | 7 | 4 | 3 | 3.6 | CC(C)C[C@@H](NC(=O)c1ccccc1NC(=O)c1cc2ccccc2[nH]1)C(=O)O | 10.1016/j.bmc.2009.02.012 | |||
15689733 | 113391 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 870 | 21 | 9 | 10 | 3.0 | COC(=O)c1cccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c1 | 10.1021/jm960509y | |||
CHEMBL3142905 | 113391 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 870 | 21 | 9 | 10 | 3.0 | COC(=O)c1cccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c1 | 10.1021/jm960509y | |||
52943046 | 24910 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 557 | 8 | 0 | 6 | 5.8 | CC(C)N(Cc1ccccc1)C(=O)CN1C(=O)C(Oc2ccccc2)c2nnc(-c3ccccc3)n2-c2ccccc21 | 10.1016/j.bmcl.2010.08.115 | |||
CHEMBL1269262 | 24910 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 557 | 8 | 0 | 6 | 5.8 | CC(C)N(Cc1ccccc1)C(=O)CN1C(=O)C(Oc2ccccc2)c2nnc(-c3ccccc3)n2-c2ccccc21 | 10.1016/j.bmcl.2010.08.115 | |||
14208305 | 74518 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 513 | 3 | 1 | 3 | 4.0 | CN1C(=O)[C@H](NC(=O)c2cccc(I)c2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL1907846 | 74518 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 513 | 3 | 1 | 3 | 4.0 | CN1C(=O)[C@H](NC(=O)c2cccc(I)c2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
14208248 | 211420 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 441 | 3 | 2 | 3 | 4.4 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccc(C(F)(F)F)cc1 | 10.1021/jm00120a002 | |||
CHEMBL73561 | 211420 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 441 | 3 | 2 | 3 | 4.4 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccc(C(F)(F)F)cc1 | 10.1021/jm00120a002 | |||
10897104 | 85370 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 573 | 7 | 3 | 5 | 4.7 | C[C@H](c1ccccc1)N1C(=O)C[C@H]2[C@H](NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)OC(C)(C)C)CCCN2C1=O | 10.1021/jm010813d | |||
CHEMBL2112237 | 85370 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 573 | 7 | 3 | 5 | 4.7 | C[C@H](c1ccccc1)N1C(=O)C[C@H]2[C@H](NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)OC(C)(C)C)CCCN2C1=O | 10.1021/jm010813d | |||
14991582 | 208028 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 871 | 21 | 7 | 8 | 4.3 | CN(C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCNC(=O)/C=C/c1ccc(Cl)cc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
CHEMBL60385 | 208028 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 871 | 21 | 7 | 8 | 4.3 | CN(C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCNC(=O)/C=C/c1ccc(Cl)cc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
14208248 | 211420 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 441 | 3 | 2 | 3 | 4.4 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccc(C(F)(F)F)cc1 | 10.1021/jm00047a021 | |||
CHEMBL73561 | 211420 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 441 | 3 | 2 | 3 | 4.4 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccc(C(F)(F)F)cc1 | 10.1021/jm00047a021 | |||
52949124 | 7663 | 4 | None | -2 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
9055 | 7663 | 4 | None | -2 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
CHEMBL1269258 | 7663 | 4 | None | -2 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
DB12694 | 7663 | 4 | None | -2 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
10008654 | 134394 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 595 | 6 | 3 | 5 | 5.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3cccc4ccccc34)C(=O)C[C@@H]12 | 10.1021/jm0501127 | |||
CHEMBL366344 | 134394 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 595 | 6 | 3 | 5 | 5.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3cccc4ccccc34)C(=O)C[C@@H]12 | 10.1021/jm0501127 | |||
71456294 | 86433 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 595 | 6 | 3 | 5 | 5.3 | CC(C)(C)OC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3cccc4ccccc34)C(=O)C[C@@H]12 | 10.1021/jm010813d | |||
CHEMBL2115133 | 86433 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 595 | 6 | 3 | 5 | 5.3 | CC(C)(C)OC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3cccc4ccccc34)C(=O)C[C@@H]12 | 10.1021/jm010813d | |||
136055866 | 63291 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 468 | 4 | 3 | 7 | 3.4 | CN1C(=O)[C@H](NC(=O)Nc2ccc(-c3noc(O)n3)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00032a003 | |||
CHEMBL163610 | 63291 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 468 | 4 | 3 | 7 | 3.4 | CN1C(=O)[C@H](NC(=O)Nc2ccc(-c3noc(O)n3)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00032a003 | |||
10509945 | 96159 | 0 | None | - | 2 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 896 | 26 | 9 | 9 | 2.1 | CCCC[C@H](NC(=O)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL2369816 | 96159 | 0 | None | - | 2 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 896 | 26 | 9 | 9 | 2.1 | CCCC[C@H](NC(=O)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
44215880 | 76183 | 0 | None | - | 2 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 441 | 8 | 4 | 3 | 4.2 | O=C(Nc1ccccc1C(=O)NC(CCc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 | 10.1021/jm200438b | |||
CHEMBL1933100 | 76183 | 0 | None | - | 2 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 441 | 8 | 4 | 3 | 4.2 | O=C(Nc1ccccc1C(=O)NC(CCc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 | 10.1021/jm200438b | |||
10507561 | 127779 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 585 | 7 | 2 | 4 | 5.4 | CC(C)N(C(=O)CN1C(=O)C(NC(=O)c2cc3ccccc3[nH]2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1021/jm9601664 | |||
CHEMBL356408 | 127779 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 585 | 7 | 2 | 4 | 5.4 | CC(C)N(C(=O)CN1C(=O)C(NC(=O)c2cc3ccccc3[nH]2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1021/jm9601664 | |||
CHEMBL2372623 | 217056 | 0 | None | -16 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/j.bmcl.2010.05.078 | |||||
44310934 | 211183 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 575 | 7 | 3 | 6 | 4.1 | COc1ccc(N2C(=O)CC3C(NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)OC(C)(C)C)CCCN3C2=O)cc1 | 10.1021/jm010813d | |||
CHEMBL71996 | 211183 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 575 | 7 | 3 | 6 | 4.1 | COc1ccc(N2C(=O)CC3C(NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)OC(C)(C)C)CCCN3C2=O)cc1 | 10.1021/jm010813d | |||
10462874 | 105612 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 766 | 16 | 6 | 5 | 7.1 | O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1)NCCCCNC(=O)Nc1ccccc1Cl | 10.1016/s0960-894x(00)00198-0 | |||
CHEMBL278780 | 105612 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 766 | 16 | 6 | 5 | 7.1 | O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1)NCCCCNC(=O)Nc1ccccc1Cl | 10.1016/s0960-894x(00)00198-0 | |||
15666987 | 214976 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 976 | 29 | 10 | 11 | 1.6 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](CCCC)NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00094a001 | |||
CHEMBL98446 | 214976 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 976 | 29 | 10 | 11 | 1.6 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](CCCC)NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00094a001 | |||
15667019 | 215008 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 905 | 26 | 9 | 10 | 2.0 | CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCNC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00094a001 | |||
CHEMBL98631 | 215008 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 905 | 26 | 9 | 10 | 2.0 | CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCNC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00094a001 | |||
14208217 | 210929 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 379 | 3 | 2 | 4 | 3.4 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccsc1 | 10.1021/jm00120a002 | |||
CHEMBL70550 | 210929 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 379 | 3 | 2 | 4 | 3.4 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccsc1 | 10.1021/jm00120a002 | |||
44381914 | 19775 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 522 | 14 | 1 | 4 | 4.7 | CCCCCN(CCCCC)C(=O)C(CCC(=O)N1CCN(C)CC1)NC(=O)c1ccc2ccccc2c1 | 10.1016/S0960-894X(00)80681-2 | |||
CHEMBL1189721 | 19775 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 522 | 14 | 1 | 4 | 4.7 | CCCCCN(CCCCC)C(=O)C(CCC(=O)N1CCN(C)CC1)NC(=O)c1ccc2ccccc2c1 | 10.1016/S0960-894X(00)80681-2 | |||
CHEMBL539320 | 19775 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 522 | 14 | 1 | 4 | 4.7 | CCCCCN(CCCCC)C(=O)C(CCC(=O)N1CCN(C)CC1)NC(=O)c1ccc2ccccc2c1 | 10.1016/S0960-894X(00)80681-2 | |||
73354295 | 112723 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 643 | 13 | 5 | 6 | 4.5 | CONC(=O)CCC(=O)N[C@H](CNC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3)c1ccccc1 | 10.1021/jm00092a007 | |||
CHEMBL312894 | 112723 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 643 | 13 | 5 | 6 | 4.5 | CONC(=O)CCC(=O)N[C@H](CNC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3)c1ccccc1 | 10.1021/jm00092a007 | |||
44311626 | 210923 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 455 | 4 | 2 | 4 | 4.8 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccc(SC(F)(F)F)cc1 | 10.1021/jm00120a002 | |||
CHEMBL70499 | 210923 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 455 | 4 | 2 | 4 | 4.8 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccc(SC(F)(F)F)cc1 | 10.1021/jm00120a002 | |||
15104623 | 16792 | 0 | None | - | 0 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 476 | 13 | 3 | 2 | 6.4 | CCCCCN(CCCCC)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)Nc1cccc(C)c1 | 10.1021/jm00116a002 | |||
CHEMBL114997 | 16792 | 0 | None | - | 0 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 476 | 13 | 3 | 2 | 6.4 | CCCCCN(CCCCC)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)Nc1cccc(C)c1 | 10.1021/jm00116a002 | |||
15104625 | 117299 | 0 | None | - | 0 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 651 | 16 | 2 | 6 | 8.3 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c(Sc2ccccc2[N+](=O)[O-])[nH]c2ccccc12)NC(=O)c1cnc2ccccc2c1 | 10.1021/jm00116a002 | |||
CHEMBL325067 | 117299 | 0 | None | - | 0 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 651 | 16 | 2 | 6 | 8.3 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c(Sc2ccccc2[N+](=O)[O-])[nH]c2ccccc12)NC(=O)c1cnc2ccccc2c1 | 10.1021/jm00116a002 | |||
44334225 | 11760 | 0 | None | - | 0 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 522 | 7 | 2 | 6 | 3.1 | Cc1cccc(NC(=O)N[C@H](COC(=O)N2CCOCC2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
CHEMBL104958 | 11760 | 0 | None | - | 0 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 522 | 7 | 2 | 6 | 3.1 | Cc1cccc(NC(=O)N[C@H](COC(=O)N2CCOCC2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
71452639 | 85226 | 0 | None | - | 0 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 542 | 9 | 2 | 5 | 4.0 | Cc1cccc(NC(=O)N[C@H](CCC(=O)OCc2ccccc2)C(=O)N2CCN(C(=O)c3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
CHEMBL2111654 | 85226 | 0 | None | - | 0 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 542 | 9 | 2 | 5 | 4.0 | Cc1cccc(NC(=O)N[C@H](CCC(=O)OCc2ccccc2)C(=O)N2CCN(C(=O)c3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
10673078 | 35860 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 502 | 6 | 3 | 4 | 5.2 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1CCCCC1C#N | 10.1021/jm970065l | |||
CHEMBL138112 | 35860 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 502 | 6 | 3 | 4 | 5.2 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1CCCCC1C#N | 10.1021/jm970065l | |||
CHEMBL406978 | 219410 | 0 | None | - | 0 | Rat | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(N)=O | 10.1021/jm00378a012 | |||||
CHEMBL2372073 | 216959 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H]1CNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1016/j.bmc.2007.05.067 | |||||
44359840 | 172227 | 0 | None | - | 0 | Rat | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 395 | 4 | 2 | 5 | 3.5 | O=C1Nc2ccccc2C(c2ccccc2F)=NC1CNc1cnc(Cl)cn1 | 10.1021/jm00163a069 | |||
CHEMBL423918 | 172227 | 0 | None | - | 0 | Rat | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 395 | 4 | 2 | 5 | 3.5 | O=C1Nc2ccccc2C(c2ccccc2F)=NC1CNc1cnc(Cl)cn1 | 10.1021/jm00163a069 | |||
44280373 | 106164 | 0 | None | - | 1 | Mouse | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 773 | 16 | 4 | 8 | 5.4 | Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
CHEMBL282646 | 106164 | 0 | None | - | 1 | Mouse | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 773 | 16 | 4 | 8 | 5.4 | Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
10839347 | 37034 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 507 | 7 | 4 | 4 | 4.8 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1(CO)CCCCC1 | 10.1021/jm970065l | |||
CHEMBL139101 | 37034 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 507 | 7 | 4 | 4 | 4.8 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1(CO)CCCCC1 | 10.1021/jm970065l | |||
45482481 | 204656 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 445 | 7 | 4 | 3 | 4.0 | O=C(Nc1ccccc1C(=O)N[C@H](Cc1ccccc1)C(=O)O)c1cc2cc(F)ccc2[nH]1 | 10.1016/j.bmc.2009.05.067 | |||
CHEMBL572649 | 204656 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 445 | 7 | 4 | 3 | 4.0 | O=C(Nc1ccccc1C(=O)N[C@H](Cc1ccccc1)C(=O)O)c1cc2cc(F)ccc2[nH]1 | 10.1016/j.bmc.2009.05.067 | |||
44336539 | 11916 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 563 | 7 | 2 | 5 | 4.6 | COc1ccc(N(C)C(=O)CN2C(=O)C(NC(=O)Nc3ccccc3)C(=O)N(c3ccccc3)c3ccccc32)cc1 | 10.1016/j.bmcl.2015.03.051 | |||
CHEMBL105775 | 11916 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 563 | 7 | 2 | 5 | 4.6 | COc1ccc(N(C)C(=O)CN2C(=O)C(NC(=O)Nc3ccccc3)C(=O)N(c3ccccc3)c3ccccc32)cc1 | 10.1016/j.bmcl.2015.03.051 | |||
10156187 | 109883 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 373 | 3 | 2 | 3 | 3.4 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccccc1 | 10.1021/jm00120a002 | |||
CHEMBL307659 | 109883 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 373 | 3 | 2 | 3 | 3.4 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccccc1 | 10.1021/jm00120a002 | |||
10156187 | 109883 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 373 | 3 | 2 | 3 | 3.4 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccccc1 | 10.1021/jm00047a021 | |||
CHEMBL307659 | 109883 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 373 | 3 | 2 | 3 | 3.4 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccccc1 | 10.1021/jm00047a021 | |||
10249484 | 29426 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 385 | 3 | 2 | 4 | 3.0 | CN1C(=O)C(NC(=O)Nc2ccncc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL132699 | 29426 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 385 | 3 | 2 | 4 | 3.0 | CN1C(=O)C(NC(=O)Nc2ccncc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
10672231 | 212736 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 475 | 5 | 3 | 4 | 4.9 | CCCN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C([C@H]2CCC(C)(C)CCN2)c2ccccc21 | 10.1021/jm9608523 | |||
CHEMBL84433 | 212736 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 475 | 5 | 3 | 4 | 4.9 | CCCN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C([C@H]2CCC(C)(C)CCN2)c2ccccc21 | 10.1021/jm9608523 | |||
14208195 | 22031 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 455 | 4 | 2 | 4 | 4.8 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1cccc(SC(F)(F)F)c1 | 10.1021/jm00047a021 | |||
CHEMBL121210 | 22031 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 455 | 4 | 2 | 4 | 4.8 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1cccc(SC(F)(F)F)c1 | 10.1021/jm00047a021 | |||
10673570 | 36929 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 521 | 7 | 4 | 4 | 4.9 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1(C(=O)O)CCCCC1 | 10.1021/jm970065l | |||
CHEMBL139001 | 36929 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 521 | 7 | 4 | 4 | 4.9 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1(C(=O)O)CCCCC1 | 10.1021/jm970065l | |||
10719765 | 85136 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 487 | 6 | 4 | 7 | 3.3 | CN1C(=O)[C@H](NC(=O)Nc2cccc(CNc3nn[nH]n3)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm9506736 | |||
CHEMBL2110202 | 85136 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 487 | 6 | 4 | 7 | 3.3 | CN1C(=O)[C@H](NC(=O)Nc2cccc(CNc3nn[nH]n3)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm9506736 | |||
44336539 | 11916 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 563 | 7 | 2 | 5 | 4.6 | COc1ccc(N(C)C(=O)CN2C(=O)C(NC(=O)Nc3ccccc3)C(=O)N(c3ccccc3)c3ccccc32)cc1 | 10.1016/j.bmcl.2015.03.051 | |||
CHEMBL105775 | 11916 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 563 | 7 | 2 | 5 | 4.6 | COc1ccc(N(C)C(=O)CN2C(=O)C(NC(=O)Nc3ccccc3)C(=O)N(c3ccccc3)c3ccccc32)cc1 | 10.1016/j.bmcl.2015.03.051 | |||
44368562 | 128741 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 588 | 12 | 5 | 5 | 4.3 | C[C@H]1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CNC(=O)/C=C/C(=O)O)Cc1ccccc1 | 10.1021/jm00057a005 | |||
CHEMBL359076 | 128741 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 588 | 12 | 5 | 5 | 4.3 | C[C@H]1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CNC(=O)/C=C/C(=O)O)Cc1ccccc1 | 10.1021/jm00057a005 | |||
10698109 | 114073 | 0 | None | 5 | 2 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 560 | 8 | 1 | 4 | 5.8 | CC(C)N(C(=O)CN1C(=O)C(CC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1021/jm960205b | |||
CHEMBL317181 | 114073 | 0 | None | 5 | 2 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 560 | 8 | 1 | 4 | 5.8 | CC(C)N(C(=O)CN1C(=O)C(CC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1021/jm960205b | |||
10698109 | 114073 | 0 | None | 5 | 2 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 560 | 8 | 1 | 4 | 5.8 | CC(C)N(C(=O)CN1C(=O)C(CC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1021/acs.jmedchem.0c00829 | |||
CHEMBL317181 | 114073 | 0 | None | 5 | 2 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 560 | 8 | 1 | 4 | 5.8 | CC(C)N(C(=O)CN1C(=O)C(CC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1021/acs.jmedchem.0c00829 | |||
10790099 | 214053 | 0 | None | - | 0 | Rat | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 459 | 7 | 3 | 7 | 4.3 | COc1ccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(OC(C)C)c2)cc1 | 10.1021/jm970373j | |||
CHEMBL9311 | 214053 | 0 | None | - | 0 | Rat | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 459 | 7 | 3 | 7 | 4.3 | COc1ccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(OC(C)C)c2)cc1 | 10.1021/jm970373j | |||
44341327 | 170111 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 504 | 13 | 3 | 2 | 6.3 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cc2cc(F)ccc2[nH]1 | 10.1021/jm00116a002 | |||
CHEMBL419031 | 170111 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 504 | 13 | 3 | 2 | 6.3 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cc2cc(F)ccc2[nH]1 | 10.1021/jm00116a002 | |||
15637206 | 85676 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 428 | 4 | 3 | 4 | 3.3 | CN1C(=O)[C@H](NC(=O)Nc2ccc(C(=O)O)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00032a003 | |||
CHEMBL2112932 | 85676 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 428 | 4 | 3 | 4 | 3.3 | CN1C(=O)[C@H](NC(=O)Nc2ccc(C(=O)O)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00032a003 | |||
9866980 | 11428 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 423 | 3 | 2 | 4 | 4.6 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N3C[C@H](C)N=C23)c1 | 10.1016/0960-894X(95)00530-0 | |||
CHEMBL103119 | 11428 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 423 | 3 | 2 | 4 | 4.6 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N3C[C@H](C)N=C23)c1 | 10.1016/0960-894X(95)00530-0 | |||
10577834 | 123522 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 518 | 6 | 3 | 4 | 5.2 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NN1CC2CCC(CC2)C1 | 10.1021/jm970065l | |||
CHEMBL337529 | 123522 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 518 | 6 | 3 | 4 | 5.2 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NN1CC2CCC(CC2)C1 | 10.1021/jm970065l | |||
10768419 | 35881 | 0 | None | - | 0 | Rat | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 525 | 10 | 5 | 5 | 3.5 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC(CC(=O)O)CC(=O)O | 10.1021/jm970065l | |||
CHEMBL138127 | 35881 | 0 | None | - | 0 | Rat | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 525 | 10 | 5 | 5 | 3.5 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC(CC(=O)O)CC(=O)O | 10.1021/jm970065l | |||
15291593 | 119629 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 537 | 6 | 2 | 5 | 5.2 | CC(C)(C)C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(N3CCCC3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm960669+ | |||
CHEMBL330933 | 119629 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 537 | 6 | 2 | 5 | 5.2 | CC(C)(C)C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(N3CCCC3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm960669+ | |||
5311201 | 214174 | 35 | None | -1174 | 6 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00001a027 | |||
CHEMBL9387 | 214174 | 35 | None | -1174 | 6 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00001a027 | |||
14208215 | 110577 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 405 | 3 | 2 | 3 | 4.4 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1cccc2ccccc12 | 10.1021/jm00047a021 | |||
CHEMBL309017 | 110577 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 405 | 3 | 2 | 3 | 4.4 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1cccc2ccccc12 | 10.1021/jm00047a021 | |||
10531430 | 119124 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 587 | 8 | 1 | 5 | 5.9 | COc1ccccc1N(C(=O)CN1C(=O)C(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc21)C(C)C | 10.1021/jm970265x | |||
CHEMBL329407 | 119124 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 587 | 8 | 1 | 5 | 5.9 | COc1ccccc1N(C(=O)CN1C(=O)C(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc21)C(C)C | 10.1021/jm970265x | |||
10391834 | 44998 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 516 | 11 | 3 | 4 | 4.5 | CC(C)N(C(=O)CN(C(=O)[C@@H](CCC(=O)O)NC(=O)Nc1ccccc1)c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(97)00062-0 | |||
CHEMBL146206 | 44998 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 516 | 11 | 3 | 4 | 4.5 | CC(C)N(C(=O)CN(C(=O)[C@@H](CCC(=O)O)NC(=O)Nc1ccccc1)c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(97)00062-0 | |||
45482491 | 205189 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 445 | 7 | 4 | 3 | 4.0 | O=C(Nc1ccccc1C(=O)NC(Cc1ccccc1)C(=O)O)c1cc2cccc(F)c2[nH]1 | 10.1016/j.bmc.2009.05.067 | |||
CHEMBL576957 | 205189 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 445 | 7 | 4 | 3 | 4.0 | O=C(Nc1ccccc1C(=O)NC(Cc1ccccc1)C(=O)O)c1cc2cccc(F)c2[nH]1 | 10.1016/j.bmc.2009.05.067 | |||
44283151 | 125945 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 531 | 9 | 4 | 4 | 5.6 | O=C(NC(Cc1c[nH]c2ccccc12)/C(S)=N/C(CO)Cc1ccccc1)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1021/jm00086a017 | |||
CHEMBL34300 | 125945 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 531 | 9 | 4 | 4 | 5.6 | O=C(NC(Cc1c[nH]c2ccccc12)/C(S)=N/C(CO)Cc1ccccc1)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1021/jm00086a017 | |||
15689739 | 113369 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 862 | 20 | 9 | 8 | 4.4 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccc2ccccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||
CHEMBL3142683 | 113369 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 862 | 20 | 9 | 8 | 4.4 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccc2ccccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||
15689738 | 113380 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 862 | 20 | 9 | 8 | 4.4 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1cccc2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||
CHEMBL3142705 | 113380 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 862 | 20 | 9 | 8 | 4.4 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1cccc2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||
CHEMBL98468 | 222706 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | None | None | None | Cc1cccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c1 | 10.1021/jm00113a023 | |||||
44286653 | 154364 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 794 | 17 | 7 | 7 | 4.2 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H]1CC(=O)N([C@@H](Cc2ccccc2)C(N)=O)C1 | 10.1021/jm00037a005 | |||
CHEMBL39310 | 154364 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 794 | 17 | 7 | 7 | 4.2 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H]1CC(=O)N([C@@H](Cc2ccccc2)C(N)=O)C1 | 10.1021/jm00037a005 | |||
CHEMBL98468 | 222706 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | None | None | None | Cc1cccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c1 | 10.1021/jm960509y | |||||
CHEMBL98468 | 222706 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | None | None | None | Cc1cccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c1 | 10.1021/jm00173a006 | |||||
44381479 | 66298 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 824 | 21 | 8 | 9 | 3.7 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)[C@@H](CCCCNC(=O)/C=C\c1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/S0960-894X(00)80680-0 | |||
CHEMBL171593 | 66298 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 824 | 21 | 8 | 9 | 3.7 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)[C@@H](CCCCNC(=O)/C=C\c1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/S0960-894X(00)80680-0 | |||
44458112 | 105483 | 0 | None | - | 1 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 374 | 4 | 2 | 3 | 2.7 | O=C(N[C@@H]1C(=O)N(c2ccccc2)C[C@@H]1C(=O)O)c1ccc2ccccc2c1 | 10.1016/S0960-894X(00)80224-3 | |||
CHEMBL277661 | 105483 | 0 | None | - | 1 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 374 | 4 | 2 | 3 | 2.7 | O=C(N[C@@H]1C(=O)N(c2ccccc2)C[C@@H]1C(=O)O)c1ccc2ccccc2c1 | 10.1016/S0960-894X(00)80224-3 | |||
CHEMBL2310857 | 216268 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N1CC(OS(=O)(=O)O)C[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00094a001 | |||||
44578422 | 188341 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 503 | 5 | 0 | 6 | 5.4 | COc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5n4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
CHEMBL476739 | 188341 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 503 | 5 | 0 | 6 | 5.4 | COc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5n4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
90663974 | 113574 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 839 | 21 | 9 | 9 | 3.0 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
CHEMBL3144536 | 113574 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 839 | 21 | 9 | 9 | 3.0 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
155550911 | 180707 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 1884 | 70 | 16 | 23 | 3.3 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL4540877 | 180707 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 1884 | 70 | 16 | 23 | 3.3 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL160753 | 215588 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | None | None | None | CN[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00031a013 | |||||
52949124 | 7663 | 4 | None | -2 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
9055 | 7663 | 4 | None | -2 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
CHEMBL1269258 | 7663 | 4 | None | -2 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
DB12694 | 7663 | 4 | None | -2 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
54586174 | 68689 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 514 | 5 | 0 | 5 | 6.2 | COc1ccc(-c2cnc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)cc1 | 10.1016/j.bmcl.2011.03.069 | |||
CHEMBL1774034 | 68689 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 514 | 5 | 0 | 5 | 6.2 | COc1ccc(-c2cnc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)cc1 | 10.1016/j.bmcl.2011.03.069 | |||
11801911 | 118292 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 613 | 8 | 1 | 5 | 6.4 | COc1ccc(N(C(=O)CN2C(=O)C(Cc3n[nH]c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C2CCCC2)cc1 | 10.1021/jm970265x | |||
CHEMBL327849 | 118292 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 613 | 8 | 1 | 5 | 6.4 | COc1ccc(N(C(=O)CN2C(=O)C(Cc3n[nH]c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C2CCCC2)cc1 | 10.1021/jm970265x | |||
15689728 | 113378 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 880 | 20 | 9 | 8 | 4.6 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1c(Cl)cccc1Cl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||
CHEMBL3142703 | 113378 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 880 | 20 | 9 | 8 | 4.6 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1c(Cl)cccc1Cl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||
44336583 | 116821 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 665 | 9 | 2 | 5 | 6.6 | CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C(=O)c3ccccc3)c2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1016/s0960-894x(98)00548-4 | |||
CHEMBL323512 | 116821 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 665 | 9 | 2 | 5 | 6.6 | CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C(=O)c3ccccc3)c2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1016/s0960-894x(98)00548-4 | |||
44293971 | 195812 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 611 | 6 | 3 | 5 | 4.8 | Cc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(C(=O)O)c1)N=C2c1ccccc1F | 10.1016/S0960-894X(96)00609-9 | |||
CHEMBL50926 | 195812 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 611 | 6 | 3 | 5 | 4.8 | Cc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(C(=O)O)c1)N=C2c1ccccc1F | 10.1016/S0960-894X(96)00609-9 | |||
9802550 | 125954 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 426 | 4 | 2 | 3 | 4.4 | CN1c2ccccc2C(c2ccccc2F)=NCC1CNC(=O)c1cc2ccccc2[nH]1 | 10.1021/jm00163a069 | |||
CHEMBL343066 | 125954 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 426 | 4 | 2 | 3 | 4.4 | CN1c2ccccc2C(c2ccccc2F)=NCC1CNC(=O)c1cc2ccccc2[nH]1 | 10.1021/jm00163a069 | |||
10047370 | 85592 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 413 | 4 | 3 | 4 | 3.1 | CN1C(=O)[C@H](NC(=O)Nc2cccc(CN)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL2112754 | 85592 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 413 | 4 | 3 | 4 | 3.1 | CN1C(=O)[C@H](NC(=O)Nc2cccc(CN)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
44578529 | 189553 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 530 | 7 | 0 | 5 | 6.8 | CCCOc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
CHEMBL479030 | 189553 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 530 | 7 | 0 | 5 | 6.8 | CCCOc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
14991544 | 113582 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 857 | 22 | 10 | 10 | 2.6 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCc1ccc(O)c(O)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
CHEMBL3144543 | 113582 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 857 | 22 | 10 | 10 | 2.6 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCc1ccc(O)c(O)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
44381481 | 127412 | 0 | None | - | 0 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 841 | 22 | 9 | 9 | 3.9 | Cc1ccccc1NC(=O)NCCCC[C@@H](CNN[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C | 10.1016/S0960-894X(00)80680-0 | |||
CHEMBL354670 | 127412 | 0 | None | - | 0 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 841 | 22 | 9 | 9 | 3.9 | Cc1ccccc1NC(=O)NCCCC[C@@H](CNN[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C | 10.1016/S0960-894X(00)80680-0 | |||
14208288 | 74457 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 349 | 2 | 1 | 3 | 3.0 | CN1C(=O)[C@@H](NC(=O)C(C)(C)C)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL1907660 | 74457 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 349 | 2 | 1 | 3 | 3.0 | CN1C(=O)[C@@H](NC(=O)C(C)(C)C)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
14208215 | 110577 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 405 | 3 | 2 | 3 | 4.4 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1cccc2ccccc12 | 10.1021/jm00120a002 | |||
CHEMBL309017 | 110577 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 405 | 3 | 2 | 3 | 4.4 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1cccc2ccccc12 | 10.1021/jm00120a002 | |||
10673039 | 65038 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 501 | 5 | 3 | 7 | 3.8 | Cc1ccc(NC(=O)N[C@@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)cc1N(C)c1nn[nH]n1 | 10.1021/jm9506736 | |||
CHEMBL168253 | 65038 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 501 | 5 | 3 | 7 | 3.8 | Cc1ccc(NC(=O)N[C@@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)cc1N(C)c1nn[nH]n1 | 10.1021/jm9506736 | |||
162672110 | 189639 | 0 | None | - | 0 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 848 | 22 | 9 | 9 | 2.0 | CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.0c00530 | |||
CHEMBL4791620 | 189639 | 0 | None | - | 0 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 848 | 22 | 9 | 9 | 2.0 | CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.0c00530 | |||
132980 | 9020 | 12 | None | - | 1 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 445 | 2 | 2 | 4 | 4.0 | Cc1cccc(c1)NC(=O)N[C@@H]1N=C(N2CC3CCC(C2)CC3)c2c(N(C1=O)C)cccc2 | 10.1021/jm9608523 | |||
881 | 9020 | 12 | None | - | 1 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 445 | 2 | 2 | 4 | 4.0 | Cc1cccc(c1)NC(=O)N[C@@H]1N=C(N2CC3CCC(C2)CC3)c2c(N(C1=O)C)cccc2 | 10.1021/jm9608523 | |||
CHEMBL420783 | 9020 | 12 | None | - | 1 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 445 | 2 | 2 | 4 | 4.0 | Cc1cccc(c1)NC(=O)N[C@@H]1N=C(N2CC3CCC(C2)CC3)c2c(N(C1=O)C)cccc2 | 10.1021/jm9608523 | |||
44348850 | 24720 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 986 | 24 | 11 | 11 | 2.0 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccc(NC(=O)[C@H](Cc2ccc(S(=O)(=O)O)cc2)NC(=O)O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00099a005 | |||
CHEMBL126008 | 24720 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 986 | 24 | 11 | 11 | 2.0 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccc(NC(=O)[C@H](Cc2ccc(S(=O)(=O)O)cc2)NC(=O)O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00099a005 | |||
3040489 | 51335 | 2 | None | - | 0 | Rat | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 318 | 4 | 1 | 2 | 3.8 | O=C1CCN(Cc2ccccc2)CC1Cc1c[nH]c2ccccc12 | 10.1016/0960-894X(94)80030-8 | |||
CHEMBL151990 | 51335 | 2 | None | - | 0 | Rat | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 318 | 4 | 1 | 2 | 3.8 | O=C1CCN(Cc2ccccc2)CC1Cc1c[nH]c2ccccc12 | 10.1016/0960-894X(94)80030-8 | |||
15167783 | 74496 | 0 | None | - | 0 | Guinea pig | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 409 | 4 | 3 | 3 | 4.3 | O=C(O)c1ccccc1C1=N[C@H](Cc2c[nH]c3ccccc23)C(=O)Nc2ccccc21 | 10.1021/jm00390a019 | |||
CHEMBL1907735 | 74496 | 0 | None | - | 0 | Guinea pig | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 409 | 4 | 3 | 3 | 4.3 | O=C(O)c1ccccc1C1=N[C@H](Cc2c[nH]c3ccccc23)C(=O)Nc2ccccc21 | 10.1021/jm00390a019 | |||
44370406 | 56661 | 0 | None | - | 0 | Guinea pig | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 529 | 16 | 2 | 4 | 6.6 | CCCCCN(CCCCC)C(=O)C(CCC(=O)OCc1ccccc1)NC(=O)Nc1ccc(Cl)cc1 | 10.1021/jm00164a020 | |||
CHEMBL156814 | 56661 | 0 | None | - | 0 | Guinea pig | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 529 | 16 | 2 | 4 | 6.6 | CCCCCN(CCCCC)C(=O)C(CCC(=O)OCc1ccccc1)NC(=O)Nc1ccc(Cl)cc1 | 10.1021/jm00164a020 | |||
132980 | 9020 | 12 | None | - | 1 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 445 | 2 | 2 | 4 | 4.0 | Cc1cccc(c1)NC(=O)N[C@@H]1N=C(N2CC3CCC(C2)CC3)c2c(N(C1=O)C)cccc2 | 10.1021/jm00032a002 | |||
881 | 9020 | 12 | None | - | 1 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 445 | 2 | 2 | 4 | 4.0 | Cc1cccc(c1)NC(=O)N[C@@H]1N=C(N2CC3CCC(C2)CC3)c2c(N(C1=O)C)cccc2 | 10.1021/jm00032a002 | |||
CHEMBL420783 | 9020 | 12 | None | - | 1 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 445 | 2 | 2 | 4 | 4.0 | Cc1cccc(c1)NC(=O)N[C@@H]1N=C(N2CC3CCC(C2)CC3)c2c(N(C1=O)C)cccc2 | 10.1021/jm00032a002 | |||
132980 | 9020 | 12 | None | - | 1 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 445 | 2 | 2 | 4 | 4.0 | Cc1cccc(c1)NC(=O)N[C@@H]1N=C(N2CC3CCC(C2)CC3)c2c(N(C1=O)C)cccc2 | 10.1016/0960-894X(95)00530-0 | |||
881 | 9020 | 12 | None | - | 1 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 445 | 2 | 2 | 4 | 4.0 | Cc1cccc(c1)NC(=O)N[C@@H]1N=C(N2CC3CCC(C2)CC3)c2c(N(C1=O)C)cccc2 | 10.1016/0960-894X(95)00530-0 | |||
CHEMBL420783 | 9020 | 12 | None | - | 1 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 445 | 2 | 2 | 4 | 4.0 | Cc1cccc(c1)NC(=O)N[C@@H]1N=C(N2CC3CCC(C2)CC3)c2c(N(C1=O)C)cccc2 | 10.1016/0960-894X(95)00530-0 | |||
71456223 | 85541 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 1006 | 25 | 11 | 11 | 1.8 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1CCCC[C@@H]1NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00099a005 | |||
CHEMBL2112635 | 85541 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 1006 | 25 | 11 | 11 | 1.8 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1CCCC[C@@H]1NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00099a005 | |||
10530003 | 103778 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 520 | 7 | 2 | 5 | 5.3 | CC(C)Oc1cccc(-n2c(CCNC(=O)Nc3ccc(Br)cc3)nc3ccccc3c2=O)c1 | 10.1021/jm970373j | |||
CHEMBL266598 | 103778 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 520 | 7 | 2 | 5 | 5.3 | CC(C)Oc1cccc(-n2c(CCNC(=O)Nc3ccc(Br)cc3)nc3ccccc3c2=O)c1 | 10.1021/jm970373j | |||
44283031 | 106765 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 613 | 13 | 2 | 5 | 6.4 | CCOC(=O)CCC(=O)N(CCc1ccccc1)CC(C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1021/jm00086a017 | |||
CHEMBL286664 | 106765 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 613 | 13 | 2 | 5 | 6.4 | CCOC(=O)CCC(=O)N(CCc1ccccc1)CC(C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1021/jm00086a017 | |||
10530003 | 103778 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 520 | 7 | 2 | 5 | 5.3 | CC(C)Oc1cccc(-n2c(CCNC(=O)Nc3ccc(Br)cc3)nc3ccccc3c2=O)c1 | 10.1016/S0960-894X(97)00108-X | |||
CHEMBL266598 | 103778 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 520 | 7 | 2 | 5 | 5.3 | CC(C)Oc1cccc(-n2c(CCNC(=O)Nc3ccc(Br)cc3)nc3ccccc3c2=O)c1 | 10.1016/S0960-894X(97)00108-X | |||
136000594 | 68641 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 517 | 4 | 2 | 7 | 5.0 | Cc1ccc(-c2nc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)ncc2-c2ccc(O)c(O)c2)cc1 | 10.1016/j.bmcl.2011.03.069 | |||
CHEMBL1773890 | 68641 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 517 | 4 | 2 | 7 | 5.0 | Cc1ccc(-c2nc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)ncc2-c2ccc(O)c(O)c2)cc1 | 10.1016/j.bmcl.2011.03.069 | |||
44379911 | 65647 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 442 | 6 | 2 | 5 | 4.8 | Cc1cccc(NC(=O)NCc2nc3ccccc3c(=O)n2-c2cccc(OC(C)C)c2)c1 | 10.1016/S0960-894X(97)00108-X | |||
CHEMBL168875 | 65647 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 442 | 6 | 2 | 5 | 4.8 | Cc1cccc(NC(=O)NCc2nc3ccccc3c(=O)n2-c2cccc(OC(C)C)c2)c1 | 10.1016/S0960-894X(97)00108-X | |||
136060576 | 94267 | 0 | None | - | 0 | Guinea pig | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 571 | 5 | 1 | 5 | 8.0 | O=C1c2ccccc2C(=O)N1Cc1c(O)ccc2c(/C=C/c3ccc(-c4ccccc4)cc3)cc3nc4ccccc4n3c12 | 10.1016/j.bmcl.2007.02.071 | |||
CHEMBL233457 | 94267 | 0 | None | - | 0 | Guinea pig | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 571 | 5 | 1 | 5 | 8.0 | O=C1c2ccccc2C(=O)N1Cc1c(O)ccc2c(/C=C/c3ccc(-c4ccccc4)cc3)cc3nc4ccccc4n3c12 | 10.1016/j.bmcl.2007.02.071 | |||
10071178 | 81270 | 2 | None | - | 2 | Guinea pig | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 427 | 7 | 4 | 3 | 3.8 | O=C(Nc1ccccc1C(=O)NC(Cc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 | 10.1016/j.bmc.2009.02.012 | |||
CHEMBL202861 | 81270 | 2 | None | - | 2 | Guinea pig | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 427 | 7 | 4 | 3 | 3.8 | O=C(Nc1ccccc1C(=O)NC(Cc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 | 10.1016/j.bmc.2009.02.012 | |||
54580265 | 68635 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 515 | 5 | 0 | 6 | 5.6 | COc1ccccc1-c1cnc(C(=O)N2CCN(c3cnc4ccccc4c3)CC2)nc1-c1ccc(C)cc1 | 10.1016/j.bmcl.2011.03.069 | |||
CHEMBL1773884 | 68635 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 515 | 5 | 0 | 6 | 5.6 | COc1ccccc1-c1cnc(C(=O)N2CCN(c3cnc4ccccc4c3)CC2)nc1-c1ccc(C)cc1 | 10.1016/j.bmcl.2011.03.069 | |||
15104632 | 117317 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 520 | 9 | 3 | 5 | 4.5 | CCOC(=O)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cnc2ccccc2c1)c1ccccc1 | 10.1021/jm00116a002 | |||
CHEMBL325161 | 117317 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 520 | 9 | 3 | 5 | 4.5 | CCOC(=O)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cnc2ccccc2c1)c1ccccc1 | 10.1021/jm00116a002 | |||
11734332 | 85367 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 551 | 6 | 3 | 5 | 4.2 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)N(C3CCCCC3)C(=O)C[C@H]12 | 10.1021/jm010813d | |||
CHEMBL2112233 | 85367 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 551 | 6 | 3 | 5 | 4.2 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)N(C3CCCCC3)C(=O)C[C@H]12 | 10.1021/jm010813d | |||
10047411 | 35378 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 414 | 4 | 2 | 4 | 3.7 | COc1ccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc1 | 10.1021/jm00078a018 | |||
CHEMBL137684 | 35378 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 414 | 4 | 2 | 4 | 3.7 | COc1ccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc1 | 10.1021/jm00078a018 | |||
71459887 | 85257 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 1006 | 25 | 11 | 11 | 1.8 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@H]1CCCC[C@@H]1NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00099a005 | |||
CHEMBL2111823 | 85257 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 1006 | 25 | 11 | 11 | 1.8 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@H]1CCCC[C@@H]1NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00099a005 | |||
52949124 | 7663 | 4 | None | -2 | 2 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
9055 | 7663 | 4 | None | -2 | 2 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
CHEMBL1269258 | 7663 | 4 | None | -2 | 2 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
DB12694 | 7663 | 4 | None | -2 | 2 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
155542545 | 179898 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 1770 | 70 | 16 | 21 | 3.9 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL4520699 | 179898 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 1770 | 70 | 16 | 21 | 3.9 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
44281204 | 106626 | 0 | None | - | 1 | Mouse | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 871 | 18 | 4 | 10 | 5.5 | CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCCCN3CCN(C(=O)CNCCCOc4cccc(CN5CCCCC5)c4)CC3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00249-1 | |||
CHEMBL285719 | 106626 | 0 | None | - | 1 | Mouse | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 871 | 18 | 4 | 10 | 5.5 | CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCCCN3CCN(C(=O)CNCCCOc4cccc(CN5CCCCC5)c4)CC3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00249-1 | |||
10649296 | 37549 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 507 | 6 | 4 | 4 | 4.8 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H]1CCCCC[C@@H]1O | 10.1021/jm970065l | |||
CHEMBL139601 | 37549 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 507 | 6 | 4 | 4 | 4.8 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H]1CCCCC[C@@H]1O | 10.1021/jm970065l | |||
10391769 | 24510 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 514 | 6 | 3 | 4 | 4.7 | COc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)c3ccccc3N(CC(=O)NC(C)(C)C)C2=O)c1 | 10.1021/jm00048a015 | |||
CHEMBL125863 | 24510 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 514 | 6 | 3 | 4 | 4.7 | COc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)c3ccccc3N(CC(=O)NC(C)(C)C)C2=O)c1 | 10.1021/jm00048a015 | |||
10601831 | 103279 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 511 | 6 | 3 | 7 | 5.0 | CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(Cl)c2Cl)c1 | 10.1021/jm970373j | |||
CHEMBL262569 | 103279 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 511 | 6 | 3 | 7 | 5.0 | CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(Cl)c2Cl)c1 | 10.1021/jm970373j | |||
44336539 | 11916 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 563 | 7 | 2 | 5 | 4.6 | COc1ccc(N(C)C(=O)CN2C(=O)C(NC(=O)Nc3ccccc3)C(=O)N(c3ccccc3)c3ccccc32)cc1 | 10.1016/j.bmcl.2015.03.051 | |||
CHEMBL105775 | 11916 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 563 | 7 | 2 | 5 | 4.6 | COc1ccc(N(C)C(=O)CN2C(=O)C(NC(=O)Nc3ccccc3)C(=O)N(c3ccccc3)c3ccccc32)cc1 | 10.1016/j.bmcl.2015.03.051 | |||
10047172 | 85590 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 410 | 4 | 2 | 3 | 4.3 | C=Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00078a018 | |||
CHEMBL2112752 | 85590 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 410 | 4 | 2 | 3 | 4.3 | C=Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00078a018 | |||
70689619 | 80413 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 592 | 6 | 1 | 5 | 6.5 | O=C1C(Cc2c[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc2N1CC(=O)N1CCCC1c1ccccc1 | 10.1016/j.bmcl.2012.02.049 | |||
CHEMBL2017825 | 80413 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 592 | 6 | 1 | 5 | 6.5 | O=C1C(Cc2c[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc2N1CC(=O)N1CCCC1c1ccccc1 | 10.1016/j.bmcl.2012.02.049 | |||
46235271 | 80423 | 2 | None | - | 2 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 649 | 7 | 1 | 6 | 6.7 | Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1021/acs.jmedchem.5b01110 | |||
CHEMBL2017835 | 80423 | 2 | None | - | 2 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 649 | 7 | 1 | 6 | 6.7 | Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1021/acs.jmedchem.5b01110 | |||
44592045 | 185684 | 0 | None | - | 0 | Guinea pig | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 441 | 8 | 4 | 3 | 4.2 | O=C(O)CC(Cc1ccccc1)NC(=O)c1ccccc1NC(=O)c1cc2ccccc2[nH]1 | 10.1016/j.bmc.2009.02.012 | |||
CHEMBL469979 | 185684 | 0 | None | - | 0 | Guinea pig | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 441 | 8 | 4 | 3 | 4.2 | O=C(O)CC(Cc1ccccc1)NC(=O)c1ccccc1NC(=O)c1cc2ccccc2[nH]1 | 10.1016/j.bmc.2009.02.012 | |||
14208252 | 74527 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 403 | 3 | 1 | 3 | 3.9 | CN1C(=O)[C@@H](NC(=O)c2ccccc2Cl)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00047a021 | |||
CHEMBL1907854 | 74527 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 403 | 3 | 1 | 3 | 3.9 | CN1C(=O)[C@@H](NC(=O)c2ccccc2Cl)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00047a021 | |||
14208256 | 211308 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 433 | 5 | 2 | 5 | 3.4 | COc1ccc(C(=O)NC2N=C(c3ccccc3F)c3ccccc3NC2=O)cc1OC | 10.1021/jm00047a021 | |||
CHEMBL72727 | 211308 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 433 | 5 | 2 | 5 | 3.4 | COc1ccc(C(=O)NC2N=C(c3ccccc3F)c3ccccc3NC2=O)cc1OC | 10.1021/jm00047a021 | |||
10341247 | 126868 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 405 | 2 | 2 | 4 | 3.4 | Cc1cccc(NC(=O)NC2N=C(N3CCCCC3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00032a002 | |||
CHEMBL350853 | 126868 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 405 | 2 | 2 | 4 | 3.4 | Cc1cccc(NC(=O)NC2N=C(N3CCCCC3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00032a002 | |||
44286672 | 107151 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 836 | 18 | 6 | 7 | 5.3 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N1CCC[C@H]1CC(=O)N(C)C(Cc1ccccc1)C(N)=O | 10.1021/jm00037a005 | |||
CHEMBL289804 | 107151 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 836 | 18 | 6 | 7 | 5.3 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N1CCC[C@H]1CC(=O)N(C)C(Cc1ccccc1)C(N)=O | 10.1021/jm00037a005 | |||
52946666 | 24908 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 600 | 9 | 2 | 7 | 5.6 | CC(C)N(Cc1ccccc1)C(=O)CN1C(=O)C(Nc2cccc(C(=O)O)c2)c2nnc(-c3ccccc3)n2-c2ccccc21 | 10.1016/j.bmcl.2010.08.115 | |||
CHEMBL1269260 | 24908 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 600 | 9 | 2 | 7 | 5.6 | CC(C)N(Cc1ccccc1)C(=O)CN1C(=O)C(Nc2cccc(C(=O)O)c2)c2nnc(-c3ccccc3)n2-c2ccccc21 | 10.1016/j.bmcl.2010.08.115 | |||
10056643 | 115984 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 918 | 21 | 8 | 8 | 5.1 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC12CC3CC(CC(C3)C1)C2)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00028a015 | |||
CHEMBL321653 | 115984 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 918 | 21 | 8 | 8 | 5.1 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC12CC3CC(CC(C3)C1)C2)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00028a015 | |||
44293810 | 108530 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 581 | 5 | 2 | 4 | 5.4 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3F)c3cccc(C)c3N(CC(=O)N3CC4CCC(CC4)C3)C2=O)c1 | 10.1016/S0960-894X(96)00609-9 | |||
CHEMBL299800 | 108530 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 581 | 5 | 2 | 4 | 5.4 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3F)c3cccc(C)c3N(CC(=O)N3CC4CCC(CC4)C3)C2=O)c1 | 10.1016/S0960-894X(96)00609-9 | |||
44578399 | 188733 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 492 | 5 | 1 | 6 | 4.7 | COc1cccc(-n2cc(C(=O)N3CCN(c4nc5ccccc5[nH]4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
CHEMBL477996 | 188733 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 492 | 5 | 1 | 6 | 4.7 | COc1cccc(-n2cc(C(=O)N3CCN(c4nc5ccccc5[nH]4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
44382329 | 127404 | 1 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 475 | 3 | 2 | 2 | 5.9 | O=C1NN(C(=S)Nc2ccc(Cl)c(C(F)(F)F)c2)[C@H](c2ccccc2)[C@H]1c1ccccc1 | 10.1016/S0960-894X(00)80684-8 | |||
CHEMBL354633 | 127404 | 1 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 475 | 3 | 2 | 2 | 5.9 | O=C1NN(C(=S)Nc2ccc(Cl)c(C(F)(F)F)c2)[C@H](c2ccccc2)[C@H]1c1ccccc1 | 10.1016/S0960-894X(00)80684-8 | |||
10603713 | 118425 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 605 | 8 | 1 | 5 | 6.0 | COc1ccc(N(C(=O)CN2C(=O)C(Cc3n[nH]c4cccc(F)c34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm970265x | |||
CHEMBL328586 | 118425 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 605 | 8 | 1 | 5 | 6.0 | COc1ccc(N(C(=O)CN2C(=O)C(Cc3n[nH]c4cccc(F)c34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm970265x | |||
10770092 | 118307 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 614 | 8 | 0 | 5 | 6.9 | COc1ccc(N(C(=O)CN2C(=O)C(C)(Cc3cn(C)c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm970265x | |||
CHEMBL327909 | 118307 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 614 | 8 | 0 | 5 | 6.9 | COc1ccc(N(C(=O)CN2C(=O)C(C)(Cc3cn(C)c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm970265x | |||
54582287 | 68643 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 501 | 5 | 0 | 6 | 5.3 | COc1ccc(-c2cnc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccccc2)cc1 | 10.1016/j.bmcl.2011.03.069 | |||
CHEMBL1773892 | 68643 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 501 | 5 | 0 | 6 | 5.3 | COc1ccc(-c2cnc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccccc2)cc1 | 10.1016/j.bmcl.2011.03.069 | |||
15689725 | 113379 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 880 | 20 | 9 | 8 | 4.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccc(C(F)(F)F)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||
CHEMBL3142704 | 113379 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 880 | 20 | 9 | 8 | 4.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccc(C(F)(F)F)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||
CHEMBL3142689 | 217910 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | None | None | None | CC(C)(C)NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||||
44458114 | 92173 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 393 | 4 | 2 | 4 | 2.2 | O=C(N[C@@H]1C(=O)N(c2ccccc2F)C[C@@H]1C(=O)O)c1cnc2ccccc2c1 | 10.1016/S0960-894X(00)80224-3 | |||
CHEMBL22630 | 92173 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 393 | 4 | 2 | 4 | 2.2 | O=C(N[C@@H]1C(=O)N(c2ccccc2F)C[C@@H]1C(=O)O)c1cnc2ccccc2c1 | 10.1016/S0960-894X(00)80224-3 | |||
3960 | 9124 | 23 | None | - | 1 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 458 | 14 | 2 | 3 | 5.2 | CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCCC | 10.1039/C6MD00052E | |||
891 | 9124 | 23 | None | - | 1 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 458 | 14 | 2 | 3 | 5.2 | CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCCC | 10.1039/C6MD00052E | |||
CHEMBL24938 | 9124 | 23 | None | - | 1 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 458 | 14 | 2 | 3 | 5.2 | CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCCC | 10.1039/C6MD00052E | |||
10463229 | 126587 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 840 | 20 | 9 | 8 | 3.8 | CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCNC(=O)Nc1ccccc1C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C | 10.1021/jm00031a013 | |||
CHEMBL348346 | 126587 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 840 | 20 | 9 | 8 | 3.8 | CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCNC(=O)Nc1ccccc1C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C | 10.1021/jm00031a013 | |||
14888714 | 84024 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 1067 | 30 | 11 | 12 | 0.9 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@@H](Cc1ccc(C(F)(F)C(=O)O)cc1)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00107a037 | |||
CHEMBL2079602 | 84024 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 1067 | 30 | 11 | 12 | 0.9 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@@H](Cc1ccc(C(F)(F)C(=O)O)cc1)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00107a037 | |||
44370461 | 126344 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 488 | 15 | 2 | 4 | 4.8 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)N1CCCC1)NC(=O)Nc1cccc(OC)c1 | 10.1021/jm00164a020 | |||
CHEMBL346070 | 126344 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 488 | 15 | 2 | 4 | 4.8 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)N1CCCC1)NC(=O)Nc1cccc(OC)c1 | 10.1021/jm00164a020 | |||
10075097 | 35417 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 511 | 6 | 2 | 5 | 3.6 | COc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 | 10.1021/jm00078a018 | |||
CHEMBL137726 | 35417 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 511 | 6 | 2 | 5 | 3.6 | COc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 | 10.1021/jm00078a018 | |||
19766160 | 65283 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 456 | 4 | 2 | 3 | 3.9 | O=C(Nc1cccc2ccccc12)NC1CCc2ccccc2N(CC(=O)N2CCCC2)C1=O | 10.1016/S0960-894X(00)80683-6 | |||
CHEMBL168386 | 65283 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 456 | 4 | 2 | 3 | 3.9 | O=C(Nc1cccc2ccccc12)NC1CCc2ccccc2N(CC(=O)N2CCCC2)C1=O | 10.1016/S0960-894X(00)80683-6 | |||
71449079 | 85402 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 639 | 11 | 5 | 7 | 4.9 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)Cc1cc(O)no1)c1ccccc1 | 10.1021/jm00092a007 | |||
CHEMBL2112334 | 85402 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 639 | 11 | 5 | 7 | 4.9 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)Cc1cc(O)no1)c1ccccc1 | 10.1021/jm00092a007 | |||
73348230 | 213141 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 634 | 11 | 5 | 5 | 4.9 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CP(C)(=O)O)c1ccccc1 | 10.1021/jm00092a007 | |||
CHEMBL87470 | 213141 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 634 | 11 | 5 | 5 | 4.9 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CP(C)(=O)O)c1ccccc1 | 10.1021/jm00092a007 | |||
14208252 | 74527 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 403 | 3 | 1 | 3 | 3.9 | CN1C(=O)[C@@H](NC(=O)c2ccccc2Cl)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL1907854 | 74527 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 403 | 3 | 1 | 3 | 3.9 | CN1C(=O)[C@@H](NC(=O)c2ccccc2Cl)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
14208256 | 211308 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 433 | 5 | 2 | 5 | 3.4 | COc1ccc(C(=O)NC2N=C(c3ccccc3F)c3ccccc3NC2=O)cc1OC | 10.1021/jm00120a002 | |||
CHEMBL72727 | 211308 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 433 | 5 | 2 | 5 | 3.4 | COc1ccc(C(=O)NC2N=C(c3ccccc3F)c3ccccc3NC2=O)cc1OC | 10.1021/jm00120a002 | |||
15104631 | 119625 | 0 | None | - | 0 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 520 | 9 | 3 | 5 | 4.5 | CCOC(=O)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cnc2ccccc2c1)c1ccccc1 | 10.1021/jm00116a002 | |||
CHEMBL330918 | 119625 | 0 | None | - | 0 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 520 | 9 | 3 | 5 | 4.5 | CCOC(=O)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cnc2ccccc2c1)c1ccccc1 | 10.1021/jm00116a002 | |||
44280114 | 11882 | 0 | None | 1 | 2 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 567 | 7 | 2 | 4 | 6.1 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1CCC(C(=O)c2ccccc2)CC1 | 10.1016/0960-894X(95)00537-3 | |||
CHEMBL105618 | 11882 | 0 | None | 1 | 2 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 567 | 7 | 2 | 4 | 6.1 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1CCC(C(=O)c2ccccc2)CC1 | 10.1016/0960-894X(95)00537-3 | |||
14208197 | 211416 | 0 | None | - | 0 | Rat | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 537 | 6 | 4 | 5 | 4.5 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NC1N=C(c2ccccc2)c2ccccc2NC1=O | 10.1021/jm00120a002 | |||
CHEMBL73535 | 211416 | 0 | None | - | 0 | Rat | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 537 | 6 | 4 | 5 | 4.5 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NC1N=C(c2ccccc2)c2ccccc2NC1=O | 10.1021/jm00120a002 | |||
15614734 | 74491 | 1 | None | - | 0 | Guinea pig | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 411 | 3 | 0 | 3 | 4.7 | CN1C(=O)[C@@H](Cc2cn(C)c3ccccc23)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00390a019 | |||
CHEMBL1907729 | 74491 | 1 | None | - | 0 | Guinea pig | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 411 | 3 | 0 | 3 | 4.7 | CN1C(=O)[C@@H](Cc2cn(C)c3ccccc23)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00390a019 | |||
10031700 | 18962 | 0 | None | - | 0 | Rat | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 486 | 7 | 2 | 4 | 3.7 | COc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC[N+](C)(C)C)C2=O)c1 | 10.1021/jm00078a018 | |||
CHEMBL1184246 | 18962 | 0 | None | - | 0 | Rat | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 486 | 7 | 2 | 4 | 3.7 | COc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC[N+](C)(C)C)C2=O)c1 | 10.1021/jm00078a018 | |||
CHEMBL340975 | 18962 | 0 | None | - | 0 | Rat | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 486 | 7 | 2 | 4 | 3.7 | COc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC[N+](C)(C)C)C2=O)c1 | 10.1021/jm00078a018 | |||
10007047 | 23695 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 524 | 5 | 3 | 3 | 5.8 | CC(C)(C)NC(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](C2CCCCC2)c2ccccc21 | 10.1021/jm00048a015 | |||
CHEMBL125253 | 23695 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 524 | 5 | 3 | 3 | 5.8 | CC(C)(C)NC(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](C2CCCCC2)c2ccccc21 | 10.1021/jm00048a015 | |||
44381641 | 175420 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 723 | 20 | 7 | 8 | 3.2 | CCCC[C@H](N[C@H](C#N)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/S0960-894X(97)00107-8 | |||
CHEMBL436253 | 175420 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 723 | 20 | 7 | 8 | 3.2 | CCCC[C@H](N[C@H](C#N)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/S0960-894X(97)00107-8 | |||
10646538 | 104142 | 0 | None | - | 0 | Rat | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 435 | 6 | 3 | 6 | 4.1 | CC(C)Oc1cccc(-n2c(NNC(=O)NC3CCCCC3)nc3ccccc3c2=O)c1 | 10.1021/jm970373j | |||
CHEMBL269606 | 104142 | 0 | None | - | 0 | Rat | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 435 | 6 | 3 | 6 | 4.1 | CC(C)Oc1cccc(-n2c(NNC(=O)NC3CCCCC3)nc3ccccc3c2=O)c1 | 10.1021/jm970373j | |||
54586149 | 68645 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 515 | 5 | 0 | 6 | 5.6 | COc1ccc(-c2cnc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2cccc(C)c2)cc1 | 10.1016/j.bmcl.2011.03.069 | |||
CHEMBL1773894 | 68645 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 515 | 5 | 0 | 6 | 5.6 | COc1ccc(-c2cnc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2cccc(C)c2)cc1 | 10.1016/j.bmcl.2011.03.069 | |||
9853654 | 29561 | 41 | None | - | 2 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 767 | 20 | 8 | 9 | 1.5 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00079a003 | |||
CHEMBL1328 | 29561 | 41 | None | - | 2 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 767 | 20 | 8 | 9 | 1.5 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00079a003 | |||
44318235 | 18849 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 513 | 7 | 2 | 4 | 3.0 | CCN(CC)C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C(c2cccc[n+]2C)c2ccccc21 | 10.1021/jm9608523 | |||
CHEMBL1183721 | 18849 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 513 | 7 | 2 | 4 | 3.0 | CCN(CC)C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C(c2cccc[n+]2C)c2ccccc21 | 10.1021/jm9608523 | |||
CHEMBL314846 | 18849 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 513 | 7 | 2 | 4 | 3.0 | CCN(CC)C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C(c2cccc[n+]2C)c2ccccc21 | 10.1021/jm9608523 | |||
10369805 | 107328 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 532 | 5 | 3 | 3 | 5.6 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2c1ccccc1 | 10.1021/jm00048a015 | |||
CHEMBL291458 | 107328 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 532 | 5 | 3 | 3 | 5.6 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2c1ccccc1 | 10.1021/jm00048a015 | |||
14208266 | 111157 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 371 | 3 | 3 | 4 | 2.9 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccc(O)cc1 | 10.1021/jm00047a021 | |||
CHEMBL310250 | 111157 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 371 | 3 | 3 | 4 | 2.9 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccc(O)cc1 | 10.1021/jm00047a021 | |||
45482484 | 204759 | 0 | None | - | 0 | Rat | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 455 | 9 | 4 | 3 | 4.2 | O=C(CCc1c[nH]c2ccccc12)Nc1ccccc1C(=O)NC(Cc1ccccc1)C(=O)O | 10.1016/j.bmc.2009.05.067 | |||
CHEMBL573555 | 204759 | 0 | None | - | 0 | Rat | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 455 | 9 | 4 | 3 | 4.2 | O=C(CCc1c[nH]c2ccccc12)Nc1ccccc1C(=O)NC(Cc1ccccc1)C(=O)O | 10.1016/j.bmc.2009.05.067 | |||
9953071 | 205844 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 404 | 3 | 2 | 3 | 4.5 | Cc1cccc(NC(=O)N[C@@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00032a002 | |||
CHEMBL58699 | 205844 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 404 | 3 | 2 | 3 | 4.5 | Cc1cccc(NC(=O)N[C@@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00032a002 | |||
9953071 | 205844 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 404 | 3 | 2 | 3 | 4.5 | Cc1cccc(NC(=O)N[C@@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(01)80987-2 | |||
CHEMBL58699 | 205844 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 404 | 3 | 2 | 3 | 4.5 | Cc1cccc(NC(=O)N[C@@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(01)80987-2 | |||
71460027 | 86490 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 541 | 9 | 4 | 4 | 5.3 | O=C(O)C[C@H](Cc1ccccc1)NC(=O)C(=Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 | 10.1016/S0960-894X(00)80273-5 | |||
CHEMBL2115544 | 86490 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 541 | 9 | 4 | 4 | 5.3 | O=C(O)C[C@H](Cc1ccccc1)NC(=O)C(=Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 | 10.1016/S0960-894X(00)80273-5 | |||
10009450 | 106642 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 649 | 7 | 3 | 7 | 4.5 | CCc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(-c3nn[nH]n3)c1)N=C2c1ccccc1F | 10.1016/s0960-894x(98)00237-6 | |||
CHEMBL285850 | 106642 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 649 | 7 | 3 | 7 | 4.5 | CCc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(-c3nn[nH]n3)c1)N=C2c1ccccc1F | 10.1016/s0960-894x(98)00237-6 | |||
14208259 | 210936 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 545 | 4 | 1 | 4 | 5.9 | O=C(NC1N=C(c2ccccc2F)c2ccccc2N(C(=O)c2ccc(Cl)cc2)C1=O)c1ccc(Cl)cc1 | 10.1021/jm00120a002 | |||
CHEMBL70593 | 210936 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 545 | 4 | 1 | 4 | 5.9 | O=C(NC1N=C(c2ccccc2F)c2ccccc2N(C(=O)c2ccc(Cl)cc2)C1=O)c1ccc(Cl)cc1 | 10.1021/jm00120a002 | |||
10260012 | 116426 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 858 | 22 | 8 | 7 | 3.7 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)Cc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00028a015 | |||
CHEMBL322391 | 116426 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 858 | 22 | 8 | 7 | 3.7 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)Cc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00028a015 | |||
3960 | 9124 | 23 | None | - | 1 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 458 | 14 | 2 | 3 | 5.2 | CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCCC | 10.1021/jm00164a020 | |||
891 | 9124 | 23 | None | - | 1 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 458 | 14 | 2 | 3 | 5.2 | CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCCC | 10.1021/jm00164a020 | |||
CHEMBL24938 | 9124 | 23 | None | - | 1 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 458 | 14 | 2 | 3 | 5.2 | CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCCC | 10.1021/jm00164a020 | |||
10074366 | 127376 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 491 | 9 | 4 | 4 | 4.5 | C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
CHEMBL3349028 | 127376 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 491 | 9 | 4 | 4 | 4.5 | C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
CHEMBL3545866 | 127376 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 491 | 9 | 4 | 4 | 4.5 | C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
44359879 | 39797 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 445 | 7 | 1 | 5 | 4.4 | COC(=O)CC(NCC1CN=C(c2ccccc2F)c2ccccc2N1C)c1ccccc1 | 10.1021/jm00163a069 | |||
CHEMBL141629 | 39797 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 445 | 7 | 1 | 5 | 4.4 | COC(=O)CC(NCC1CN=C(c2ccccc2F)c2ccccc2N1C)c1ccccc1 | 10.1021/jm00163a069 | |||
44458049 | 105873 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 363 | 4 | 3 | 3 | 2.0 | O=C(N[C@@H]1C(=O)N(c2ccccc2)C[C@@H]1C(=O)O)c1cc2ccccc2[nH]1 | 10.1016/S0960-894X(00)80224-3 | |||
CHEMBL280733 | 105873 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 363 | 4 | 3 | 3 | 2.0 | O=C(N[C@@H]1C(=O)N(c2ccccc2)C[C@@H]1C(=O)O)c1cc2ccccc2[nH]1 | 10.1016/S0960-894X(00)80224-3 | |||
44372113 | 17042 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 1105 | 30 | 11 | 13 | 2.4 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NC | 10.1021/jm00031a013 | |||
CHEMBL1161390 | 17042 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 1105 | 30 | 11 | 13 | 2.4 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NC | 10.1021/jm00031a013 | |||
10369805 | 107328 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 532 | 5 | 3 | 3 | 5.6 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2c1ccccc1 | 10.1016/0960-894X(95)00327-P | |||
CHEMBL291458 | 107328 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 532 | 5 | 3 | 3 | 5.6 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2c1ccccc1 | 10.1016/0960-894X(95)00327-P | |||
15104630 | 16337 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 462 | 7 | 3 | 3 | 4.9 | C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cnc2ccccc2c1)c1ccccc1 | 10.1021/jm00116a002 | |||
CHEMBL112387 | 16337 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 462 | 7 | 3 | 3 | 4.9 | C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cnc2ccccc2c1)c1ccccc1 | 10.1021/jm00116a002 | |||
44362746 | 125769 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 680 | 12 | 3 | 6 | 5.7 | C[Si](C)(C)CCOC(=O)C[C@@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@H]2C[C@H](NC(=O)OCc3ccccc3)C(=O)N12 | 10.1016/s0960-894x(98)00677-5 | |||
CHEMBL342520 | 125769 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 680 | 12 | 3 | 6 | 5.7 | C[Si](C)(C)CCOC(=O)C[C@@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@H]2C[C@H](NC(=O)OCc3ccccc3)C(=O)N12 | 10.1016/s0960-894x(98)00677-5 | |||
10252412 | 32544 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 435 | 3 | 2 | 4 | 4.2 | CN1C(=O)C(NC(=O)Nc2ccc3ccccc3n2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL135289 | 32544 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 435 | 3 | 2 | 4 | 4.2 | CN1C(=O)C(NC(=O)Nc2ccc3ccccc3n2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
14991537 | 113573 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 921 | 24 | 9 | 11 | 2.4 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCc1cccc(OS(=O)(=O)O)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
CHEMBL3144535 | 113573 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 921 | 24 | 9 | 11 | 2.4 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCc1cccc(OS(=O)(=O)O)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
CHEMBL3143668 | 217958 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/0960-894X(96)00160-6 | |||||
CHEMBL64605 | 222635 | 7 | None | -1288 | 3 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00105a068 | |||||
44381749 | 19670 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 540 | 14 | 1 | 4 | 4.9 | CCCCCN(CCCCC)C(=O)C(CCC(=O)N1CCN(C)CC1)NC(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/S0960-894X(00)80681-2 | |||
CHEMBL1188959 | 19670 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 540 | 14 | 1 | 4 | 4.9 | CCCCCN(CCCCC)C(=O)C(CCC(=O)N1CCN(C)CC1)NC(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/S0960-894X(00)80681-2 | |||
CHEMBL537834 | 19670 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 540 | 14 | 1 | 4 | 4.9 | CCCCCN(CCCCC)C(=O)C(CCC(=O)N1CCN(C)CC1)NC(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/S0960-894X(00)80681-2 | |||
CHEMBL64605 | 222635 | 7 | None | -1288 | 3 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00173a006 | |||||
CHEMBL64605 | 222635 | 7 | None | -1288 | 3 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/S0960-894X(00)80680-0 | |||||
CHEMBL64605 | 222635 | 7 | None | - | 3 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm050689o | |||||
14208266 | 111157 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 371 | 3 | 3 | 4 | 2.9 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccc(O)cc1 | 10.1021/jm00120a002 | |||
CHEMBL310250 | 111157 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 371 | 3 | 3 | 4 | 2.9 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccc(O)cc1 | 10.1021/jm00120a002 | |||
CHEMBL64605 | 222635 | 7 | None | -1288 | 3 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.0c00530 | |||||
9953071 | 205844 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 404 | 3 | 2 | 3 | 4.5 | Cc1cccc(NC(=O)N[C@@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm9608523 | |||
CHEMBL58699 | 205844 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 404 | 3 | 2 | 3 | 4.5 | Cc1cccc(NC(=O)N[C@@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm9608523 | |||
CHEMBL64605 | 222635 | 7 | None | -1288 | 3 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||||
44334258 | 11236 | 0 | None | - | 0 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 451 | 8 | 3 | 4 | 3.5 | Cc1cccc(NC(=O)N[C@H](CCC(=O)O)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
CHEMBL101752 | 11236 | 0 | None | - | 0 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 451 | 8 | 3 | 4 | 3.5 | Cc1cccc(NC(=O)N[C@H](CCC(=O)O)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
44334452 | 11331 | 0 | None | - | 0 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 497 | 9 | 2 | 3 | 5.6 | Cc1cccc(NC(=O)N[C@H](CCCc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
CHEMBL102461 | 11331 | 0 | None | - | 0 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 497 | 9 | 2 | 3 | 5.6 | Cc1cccc(NC(=O)N[C@H](CCCc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
CHEMBL64605 | 222635 | 7 | None | -1288 | 3 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/S0960-894X(97)00107-8 | |||||
15673181 | 92771 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 629 | 12 | 6 | 6 | 4.3 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)NO)c1ccccc1 | 10.1016/S0960-894X(00)80652-6 | |||
CHEMBL2304156 | 92771 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 629 | 12 | 6 | 6 | 4.3 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)NO)c1ccccc1 | 10.1016/S0960-894X(00)80652-6 | |||
44354125 | 29923 | 0 | None | - | 0 | Rat | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 628 | 13 | 5 | 5 | 5.2 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCC[C@H](NC(=O)CCC(=O)O)c1ccccc1 | 10.1021/jm00105a062 | |||
CHEMBL133101 | 29923 | 0 | None | - | 0 | Rat | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 628 | 13 | 5 | 5 | 5.2 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCC[C@H](NC(=O)CCC(=O)O)c1ccccc1 | 10.1021/jm00105a062 | |||
14802539 | 83327 | 1 | None | - | 1 | Rat | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1 | 10.1016/S0960-894X(00)80685-X | |||
CHEMBL2062144 | 83327 | 1 | None | - | 1 | Rat | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1 | 10.1016/S0960-894X(00)80685-X | |||
44286962 | 107254 | 0 | None | - | 0 | Guinea pig | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 810 | 21 | 8 | 7 | 4.9 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)NCCCCC(=O)NC(Cc1ccccc1)C(N)=O | 10.1021/jm00037a005 | |||
CHEMBL290896 | 107254 | 0 | None | - | 0 | Guinea pig | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 810 | 21 | 8 | 7 | 4.9 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)NCCCCC(=O)NC(Cc1ccccc1)C(N)=O | 10.1021/jm00037a005 | |||
44368521 | 53068 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 576 | 12 | 5 | 5 | 4.6 | C[C@H]1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1 | 10.1021/jm00057a005 | |||
CHEMBL153557 | 53068 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 576 | 12 | 5 | 5 | 4.6 | C[C@H]1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1 | 10.1021/jm00057a005 | |||
23844130 | 16886 | 16 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 484 | 5 | 3 | 6 | 3.6 | CC(C)(C)C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(N)c2)N=C(c2ccccn2)c2ccccc21 | 10.1021/jm960669+ | |||
CHEMBL115612 | 16886 | 16 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 484 | 5 | 3 | 6 | 3.6 | CC(C)(C)C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(N)c2)N=C(c2ccccn2)c2ccccc21 | 10.1021/jm960669+ | |||
45482479 | 204623 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 461 | 7 | 4 | 3 | 4.5 | O=C(Nc1ccccc1C(=O)NC(Cc1ccccc1)C(=O)O)c1cc2cc(Cl)ccc2[nH]1 | 10.1016/j.bmc.2009.05.067 | |||
CHEMBL572412 | 204623 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 461 | 7 | 4 | 3 | 4.5 | O=C(Nc1ccccc1C(=O)NC(Cc1ccccc1)C(=O)O)c1cc2cc(Cl)ccc2[nH]1 | 10.1016/j.bmc.2009.05.067 | |||
71719689 | 92764 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 500 | 8 | 3 | 4 | 4.8 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccn1 | 10.1016/S0960-894X(01)80769-1 | |||
CHEMBL2304063 | 92764 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 500 | 8 | 3 | 4 | 4.8 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccn1 | 10.1016/S0960-894X(01)80769-1 | |||
44381925 | 19624 | 0 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 538 | 11 | 2 | 4 | 4.5 | CCN(CC)CCNC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1016/S0960-894X(00)80681-2 | |||
CHEMBL1188615 | 19624 | 0 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 538 | 11 | 2 | 4 | 4.5 | CCN(CC)CCNC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1016/S0960-894X(00)80681-2 | |||
CHEMBL536938 | 19624 | 0 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 538 | 11 | 2 | 4 | 4.5 | CCN(CC)CCNC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1016/S0960-894X(00)80681-2 | |||
5311347 | 114133 | 3 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@@H](CC(=O)O)Cc1ccccc1 | 10.1016/S0960-894X(01)80769-1 | |||
CHEMBL317675 | 114133 | 3 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@@H](CC(=O)O)Cc1ccccc1 | 10.1016/S0960-894X(01)80769-1 | |||
5311347 | 39800 | 3 | None | - | 1 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccccc1 | 10.1016/S0960-894X(00)80685-X | |||
CHEMBL141630 | 39800 | 3 | None | - | 1 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccccc1 | 10.1016/S0960-894X(00)80685-X | |||
5311347 | 114133 | 3 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@@H](CC(=O)O)Cc1ccccc1 | 10.1021/jm00057a005 | |||
CHEMBL317675 | 114133 | 3 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@@H](CC(=O)O)Cc1ccccc1 | 10.1021/jm00057a005 | |||
5311347 | 39800 | 3 | None | - | 1 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccccc1 | 10.1021/jm970065l | |||
CHEMBL141630 | 39800 | 3 | None | - | 1 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccccc1 | 10.1021/jm970065l | |||
45482097 | 205141 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 427 | 7 | 4 | 3 | 3.8 | O=C(NC(Cc1ccccc1)C(=O)O)c1ccccc1NC(=O)c1c[nH]c2ccccc12 | 10.1016/j.bmc.2009.05.067 | |||
CHEMBL576584 | 205141 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 427 | 7 | 4 | 3 | 3.8 | O=C(NC(Cc1ccccc1)C(=O)O)c1ccccc1NC(=O)c1c[nH]c2ccccc12 | 10.1016/j.bmc.2009.05.067 | |||
10649606 | 56390 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 519 | 6 | 3 | 4 | 4.5 | O=C(CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)Nc1ccccc1 | 10.1016/j.bmcl.2015.03.051 | |||
CHEMBL156605 | 56390 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 519 | 6 | 3 | 4 | 4.5 | O=C(CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)Nc1ccccc1 | 10.1016/j.bmcl.2015.03.051 | |||
44349024 | 23903 | 0 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 402 | 8 | 3 | 3 | 3.5 | CC(C)(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1ccc(Cl)c(Cl)c1 | 10.1021/jm00079a003 | |||
CHEMBL125551 | 23903 | 0 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 402 | 8 | 3 | 3 | 3.5 | CC(C)(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1ccc(Cl)c(Cl)c1 | 10.1021/jm00079a003 | |||
44381851 | 127156 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 723 | 20 | 7 | 8 | 3.2 | CCCC[C@H](N[C@H](C#N)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(=O)N[C@@H](Cc1ccccc1)C(N)=O)C(=O)O | 10.1016/S0960-894X(97)00107-8 | |||
CHEMBL353305 | 127156 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 723 | 20 | 7 | 8 | 3.2 | CCCC[C@H](N[C@H](C#N)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(=O)N[C@@H](Cc1ccccc1)C(N)=O)C(=O)O | 10.1016/S0960-894X(97)00107-8 | |||
44283500 | 146041 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 516 | 9 | 3 | 5 | 4.8 | O=C(NC(Cc1c[nH]c2ccccc12)C(=O)OC(CO)Cc1ccccc1)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1021/jm00086a017 | |||
CHEMBL37903 | 146041 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 516 | 9 | 3 | 5 | 4.8 | O=C(NC(Cc1c[nH]c2ccccc12)C(=O)OC(CO)Cc1ccccc1)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1021/jm00086a017 | |||
11753772 | 32763 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 455 | 6 | 2 | 4 | 3.9 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CCN(C)C)C2=O)c1 | 10.1021/jm00078a018 | |||
CHEMBL135447 | 32763 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 455 | 6 | 2 | 4 | 3.9 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CCN(C)C)C2=O)c1 | 10.1021/jm00078a018 | |||
15689734 | 113386 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 854 | 21 | 9 | 9 | 3.5 | CC(=O)c1cccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c1 | 10.1021/jm00113a023 | |||
CHEMBL3142899 | 113386 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 854 | 21 | 9 | 9 | 3.5 | CC(=O)c1cccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c1 | 10.1021/jm00113a023 | |||
367892 | 16304 | 1 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 429 | 14 | 3 | 3 | 4.3 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1cc2ccccc2[nH]1 | 10.1021/jm00124a003 | |||
CHEMBL112222 | 16304 | 1 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 429 | 14 | 3 | 3 | 4.3 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1cc2ccccc2[nH]1 | 10.1021/jm00124a003 | |||
44287094 | 107077 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 824 | 20 | 6 | 7 | 5.2 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N(C)CCCC(=O)N(C)C(Cc1ccccc1)C(N)=O | 10.1021/jm00037a005 | |||
CHEMBL289209 | 107077 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 824 | 20 | 6 | 7 | 5.2 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N(C)CCCC(=O)N(C)C(Cc1ccccc1)C(N)=O | 10.1021/jm00037a005 | |||
15689734 | 113386 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 854 | 21 | 9 | 9 | 3.5 | CC(=O)c1cccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c1 | 10.1021/jm960509y | |||
CHEMBL3142899 | 113386 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 854 | 21 | 9 | 9 | 3.5 | CC(=O)c1cccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c1 | 10.1021/jm960509y | |||
54584255 | 68691 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 515 | 5 | 0 | 6 | 5.6 | COc1ccc(-c2cnc(C(=O)N3CCN(c4ccc5ncccc5c4)CC3)nc2-c2ccc(C)cc2)cc1 | 10.1016/j.bmcl.2011.03.069 | |||
CHEMBL1774036 | 68691 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 515 | 5 | 0 | 6 | 5.6 | COc1ccc(-c2cnc(C(=O)N3CCN(c4ccc5ncccc5c4)CC3)nc2-c2ccc(C)cc2)cc1 | 10.1016/j.bmcl.2011.03.069 | |||
14208275 | 74521 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 443 | 3 | 1 | 3 | 4.7 | CN1C(=O)[C@@H](NC(=O)c2ccc(C(C)(C)C)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL1907849 | 74521 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 443 | 3 | 1 | 3 | 4.7 | CN1C(=O)[C@@H](NC(=O)c2ccc(C(C)(C)C)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
14208226 | 84603 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 426 | 3 | 2 | 3 | 3.9 | CN1C(=O)[C@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL2092871 | 84603 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 426 | 3 | 2 | 3 | 3.9 | CN1C(=O)[C@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
10011017 | 115509 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 916 | 22 | 8 | 7 | 5.1 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC12CC3CC(CC(C3)C1)C2)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00028a015 | |||
CHEMBL320854 | 115509 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 916 | 22 | 8 | 7 | 5.1 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC12CC3CC(CC(C3)C1)C2)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00028a015 | |||
367892 | 16304 | 1 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 429 | 14 | 3 | 3 | 4.3 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1cc2ccccc2[nH]1 | 10.1021/jm00116a002 | |||
CHEMBL112222 | 16304 | 1 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 429 | 14 | 3 | 3 | 4.3 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1cc2ccccc2[nH]1 | 10.1021/jm00116a002 | |||
14991579 | 107767 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 862 | 21 | 9 | 8 | 3.7 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C/c1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
CHEMBL294304 | 107767 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 862 | 21 | 9 | 8 | 3.7 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C/c1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
14208275 | 74521 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 443 | 3 | 1 | 3 | 4.7 | CN1C(=O)[C@@H](NC(=O)c2ccc(C(C)(C)C)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00047a021 | |||
CHEMBL1907849 | 74521 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 443 | 3 | 1 | 3 | 4.7 | CN1C(=O)[C@@H](NC(=O)c2ccc(C(C)(C)C)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00047a021 | |||
155531277 | 178410 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 1821 | 72 | 18 | 23 | 2.1 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL4465747 | 178410 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 1821 | 72 | 18 | 23 | 2.1 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
52944224 | 24907 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 586 | 8 | 2 | 7 | 5.6 | CC(C)N(C(=O)CN1C(=O)C(Nc2cccc(C(=O)O)c2)c2nnc(-c3ccccc3)n2-c2ccccc21)c1ccccc1 | 10.1016/j.bmcl.2010.08.115 | |||
CHEMBL1269259 | 24907 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 586 | 8 | 2 | 7 | 5.6 | CC(C)N(C(=O)CN1C(=O)C(Nc2cccc(C(=O)O)c2)c2nnc(-c3ccccc3)n2-c2ccccc21)c1ccccc1 | 10.1016/j.bmcl.2010.08.115 | |||
10478703 | 126690 | 1 | None | - | 1 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 445 | 2 | 2 | 4 | 4.0 | Cc1cccc(NC(=O)NC2N=C(N3CC4CCC(CC4)C3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00032a002 | |||
CHEMBL349291 | 126690 | 1 | None | - | 1 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 445 | 2 | 2 | 4 | 4.0 | Cc1cccc(NC(=O)NC2N=C(N3CC4CCC(CC4)C3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00032a002 | |||
14208271 | 109672 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 455 | 3 | 1 | 3 | 4.4 | CN1C(=O)C(NC(=O)c2ccc(C(F)(F)F)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00047a021 | |||
CHEMBL305951 | 109672 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 455 | 3 | 1 | 3 | 4.4 | CN1C(=O)C(NC(=O)c2ccc(C(F)(F)F)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00047a021 | |||
14208214 | 172027 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 405 | 3 | 2 | 3 | 4.4 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccc2ccccc2c1 | 10.1021/jm00047a021 | |||
CHEMBL422951 | 172027 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 405 | 3 | 2 | 3 | 4.4 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccc2ccccc2c1 | 10.1021/jm00047a021 | |||
44306744 | 109443 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 782 | 20 | 9 | 7 | 2.5 | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NC(CCCCNC(=O)Nc1ccccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccc(C)cc1)C(N)=O | 10.1021/jm00001a027 | |||
CHEMBL304524 | 109443 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 782 | 20 | 9 | 7 | 2.5 | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NC(CCCCNC(=O)Nc1ccccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccc(C)cc1)C(N)=O | 10.1021/jm00001a027 | |||
CHEMBL1172253 | 215364 | 0 | None | -138 | 4 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/j.bmcl.2010.05.078 | |||||
CHEMBL319438 | 217996 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00017a022 | |||||
44304324 | 207482 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 515 | 13 | 2 | 2 | 7.0 | CCCCCN(CCCCC)C(=O)C(Cc1c[nH]c2ccccc12)NC(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/S0960-894X(97)00353-3 | |||
CHEMBL59993 | 207482 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 515 | 13 | 2 | 2 | 7.0 | CCCCCN(CCCCC)C(=O)C(Cc1c[nH]c2ccccc12)NC(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/S0960-894X(97)00353-3 | |||
444998 | 216098 | 30 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00173a006 | |||||
CHEMBL216166 | 216098 | 30 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00173a006 | |||||
44382563 | 127530 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 742 | 15 | 5 | 7 | 5.3 | O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1)NCCc1ccc(OS(=O)(=O)O)cc1 | 10.1016/S0960-894X(00)80687-3 | |||
CHEMBL355052 | 127530 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 742 | 15 | 5 | 7 | 5.3 | O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1)NCCc1ccc(OS(=O)(=O)O)cc1 | 10.1016/S0960-894X(00)80687-3 | |||
15104599 | 16787 | 0 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 515 | 13 | 2 | 2 | 7.0 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccc(Cl)c(Cl)c1 | 10.1021/jm00116a002 | |||
CHEMBL114980 | 16787 | 0 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 515 | 13 | 2 | 2 | 7.0 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccc(Cl)c(Cl)c1 | 10.1021/jm00116a002 | |||
11757086 | 32448 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 541 | 10 | 2 | 6 | 4.2 | CCN(CC)CC(=O)OCCN1C(=O)C(NC(=O)Nc2cccc(C)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL135218 | 32448 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 541 | 10 | 2 | 6 | 4.2 | CCN(CC)CC(=O)OCCN1C(=O)C(NC(=O)Nc2cccc(C)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
44578456 | 196375 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 503 | 5 | 0 | 6 | 5.4 | COc1cccc(-n2cc(C(=O)N3CCN(c4ccc5cnccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
CHEMBL514716 | 196375 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 503 | 5 | 0 | 6 | 5.4 | COc1cccc(-n2cc(C(=O)N3CCN(c4ccc5cnccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
44279811 | 103700 | 0 | None | - | 1 | Mouse | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 743 | 15 | 4 | 7 | 5.3 | CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00248-X | |||
CHEMBL265987 | 103700 | 0 | None | - | 1 | Mouse | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 743 | 15 | 4 | 7 | 5.3 | CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00248-X | |||
44280028 | 105953 | 0 | None | - | 1 | Mouse | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 768 | 17 | 6 | 9 | 4.3 | CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCCCC(=O)NCCSCc3csc(N=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00248-X | |||
CHEMBL281318 | 105953 | 0 | None | - | 1 | Mouse | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 768 | 17 | 6 | 9 | 4.3 | CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCCCC(=O)NCCSCc3csc(N=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00248-X | |||
44333341 | 114563 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 448 | 4 | 2 | 5 | 2.9 | CCCN1C(=O)[C@@H](NC(=O)Nc2cccc(C)c2)N=C(N2CCN(C)CC2)c2ccccc21 | 10.1016/0960-894X(95)00530-0 | |||
CHEMBL319180 | 114563 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 448 | 4 | 2 | 5 | 2.9 | CCCN1C(=O)[C@@H](NC(=O)Nc2cccc(C)c2)N=C(N2CCN(C)CC2)c2ccccc21 | 10.1016/0960-894X(95)00530-0 | |||
13809514 | 210882 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 412 | 5 | 2 | 4 | 2.5 | CN1C(=O)[C@@H](NC(=O)[C@H](N)Cc2ccccc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL70259 | 210882 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 412 | 5 | 2 | 4 | 2.5 | CN1C(=O)[C@@H](NC(=O)[C@H](N)Cc2ccccc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
121964 | 6995 | 34 | None | - | 2 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00100a033 | |||||
858 | 6995 | 34 | None | - | 2 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00100a033 | |||||
CHEMBL323521 | 6995 | 34 | None | - | 2 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00100a033 | |||||
44334345 | 170633 | 0 | None | - | 0 | Guinea pig | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 504 | 8 | 2 | 4 | 4.0 | Cc1cccc(NC(=O)N[C@H](CCC(=O)N2CCCC2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
CHEMBL420658 | 170633 | 0 | None | - | 0 | Guinea pig | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 504 | 8 | 2 | 4 | 4.0 | Cc1cccc(NC(=O)N[C@H](CCC(=O)N2CCCC2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
367893 | 58394 | 1 | None | - | 0 | Guinea pig | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 429 | 14 | 3 | 3 | 4.3 | CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)O)NC(=O)c1cc2ccccc2[nH]1 | 10.1021/jm00124a003 | |||
CHEMBL158362 | 58394 | 1 | None | - | 0 | Guinea pig | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 429 | 14 | 3 | 3 | 4.3 | CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)O)NC(=O)c1cc2ccccc2[nH]1 | 10.1021/jm00124a003 | |||
44408526 | 143723 | 0 | None | -2344 | 4 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 1148 | 30 | 11 | 15 | 3.0 | CCCC[C@@H](C(=O)N[C@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)C(=O)O)N(C)C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O | 10.1021/jm050851n | |||
CHEMBL374325 | 143723 | 0 | None | -2344 | 4 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 1148 | 30 | 11 | 15 | 3.0 | CCCC[C@@H](C(=O)N[C@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)C(=O)O)N(C)C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O | 10.1021/jm050851n | |||
16100409 | 90009 | 0 | None | -870 | 3 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 1031 | 27 | 13 | 12 | 0.2 | CCCC[C@@H](NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](N)Cc1ccccc1)C(=O)N[C@@H](Cc1cc2ccccc2[nH]1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm061268p | |||
CHEMBL218651 | 90009 | 0 | None | -870 | 3 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 1031 | 27 | 13 | 12 | 0.2 | CCCC[C@@H](NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](N)Cc1ccccc1)C(=O)N[C@@H](Cc1cc2ccccc2[nH]1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm061268p | |||
44303251 | 109011 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 618 | 12 | 5 | 5 | 4.6 | O=C(O)CCC(=O)N[C@@H](CNC(=O)C(Cc1c[nH]c2ccc(F)cc12)NC(=O)OC1C2CC3CC(C2)CC1C3)c1ccccc1 | 10.1016/S0960-894X(97)00356-9 | |||
CHEMBL303020 | 109011 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 618 | 12 | 5 | 5 | 4.6 | O=C(O)CCC(=O)N[C@@H](CNC(=O)C(Cc1c[nH]c2ccc(F)cc12)NC(=O)OC1C2CC3CC(C2)CC1C3)c1ccccc1 | 10.1016/S0960-894X(97)00356-9 | |||
44349325 | 175327 | 0 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 465 | 7 | 3 | 4 | 3.1 | O=C(O)CCC(NC(=O)c1cccc(Br)c1)C(=O)NN1CCC2(CCCC2)CC1 | 10.1021/jm00079a003 | |||
CHEMBL435587 | 175327 | 0 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 465 | 7 | 3 | 4 | 3.1 | O=C(O)CCC(NC(=O)c1cccc(Br)c1)C(=O)NN1CCC2(CCCC2)CC1 | 10.1021/jm00079a003 | |||
9827037 | 85604 | 8 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 493 | 6 | 4 | 4 | 4.4 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H]1CCCC[C@@H]1O | 10.1021/jm970065l | |||
CHEMBL2112795 | 85604 | 8 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 493 | 6 | 4 | 4 | 4.4 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H]1CCCC[C@@H]1O | 10.1021/jm970065l | |||
CHEMBL379405 | 219044 | 0 | None | -11 | 4 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm050921q | |||||
1614 | 9128 | 67 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 460 | 14 | 2 | 4 | 4.0 | CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCOC | 10.1021/jm051050n | |||
60182 | 9128 | 67 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 460 | 14 | 2 | 4 | 4.0 | CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCOC | 10.1021/jm051050n | |||
892 | 9128 | 67 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 460 | 14 | 2 | 4 | 4.0 | CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCOC | 10.1021/jm051050n | |||
CHEMBL206025 | 9128 | 67 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 460 | 14 | 2 | 4 | 4.0 | CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCOC | 10.1021/jm051050n | |||
44368368 | 127855 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 481 | 8 | 3 | 3 | 5.1 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1CCCCC1Cl)C(=O)NCCc1ccccc1 | 10.1021/jm00057a005 | |||
CHEMBL357027 | 127855 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 481 | 8 | 3 | 3 | 5.1 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1CCCCC1Cl)C(=O)NCCc1ccccc1 | 10.1021/jm00057a005 | |||
10071178 | 81270 | 2 | None | 501 | 2 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 427 | 7 | 4 | 3 | 3.8 | O=C(Nc1ccccc1C(=O)NC(Cc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 | 10.1021/jm051050n | |||
CHEMBL202861 | 81270 | 2 | None | 501 | 2 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 427 | 7 | 4 | 3 | 3.8 | O=C(Nc1ccccc1C(=O)NC(Cc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 | 10.1021/jm051050n | |||
136060576 | 94267 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 571 | 5 | 1 | 5 | 8.0 | O=C1c2ccccc2C(=O)N1Cc1c(O)ccc2c(/C=C/c3ccc(-c4ccccc4)cc3)cc3nc4ccccc4n3c12 | 10.1016/j.bmcl.2007.02.071 | |||
CHEMBL233457 | 94267 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 571 | 5 | 1 | 5 | 8.0 | O=C1c2ccccc2C(=O)N1Cc1c(O)ccc2c(/C=C/c3ccc(-c4ccccc4)cc3)cc3nc4ccccc4n3c12 | 10.1016/j.bmcl.2007.02.071 | |||
10071178 | 81270 | 2 | None | - | 2 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 427 | 7 | 4 | 3 | 3.8 | O=C(Nc1ccccc1C(=O)NC(Cc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 | 10.1021/jm200438b | |||
CHEMBL202861 | 81270 | 2 | None | - | 2 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 427 | 7 | 4 | 3 | 3.8 | O=C(Nc1ccccc1C(=O)NC(Cc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 | 10.1021/jm200438b | |||
10071178 | 81270 | 2 | None | - | 2 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 427 | 7 | 4 | 3 | 3.8 | O=C(Nc1ccccc1C(=O)NC(Cc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 | 10.1016/j.bmc.2009.05.067 | |||
CHEMBL202861 | 81270 | 2 | None | - | 2 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 427 | 7 | 4 | 3 | 3.8 | O=C(Nc1ccccc1C(=O)NC(Cc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 | 10.1016/j.bmc.2009.05.067 | |||
10071178 | 81270 | 2 | None | - | 2 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 427 | 7 | 4 | 3 | 3.8 | O=C(Nc1ccccc1C(=O)NC(Cc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 | 10.1016/j.bmc.2009.02.012 | |||
CHEMBL202861 | 81270 | 2 | None | - | 2 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 427 | 7 | 4 | 3 | 3.8 | O=C(Nc1ccccc1C(=O)NC(Cc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 | 10.1016/j.bmc.2009.02.012 | |||
44283081 | 106647 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 500 | 9 | 3 | 3 | 6.4 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(O)CCCc1ccccc1 | 10.1021/jm00086a017 | |||
CHEMBL2112071 | 106647 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 500 | 9 | 3 | 3 | 6.4 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(O)CCCc1ccccc1 | 10.1021/jm00086a017 | |||
CHEMBL285880 | 106647 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 500 | 9 | 3 | 3 | 6.4 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(O)CCCc1ccccc1 | 10.1021/jm00086a017 | |||
44327456 | 214621 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 585 | 11 | 2 | 5 | 5.7 | COC(=O)CCN(CCc1ccccc1)C(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1016/S0960-894X(01)80769-1 | |||
CHEMBL96401 | 214621 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 585 | 11 | 2 | 5 | 5.7 | COC(=O)CCN(CCc1ccccc1)C(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1016/S0960-894X(01)80769-1 | |||
44303652 | 207469 | 0 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 570 | 8 | 2 | 3 | 7.2 | CC(Cc1ccc2c(c1)C(C)(C)CCC2(C)C)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 | 10.1016/S0960-894X(97)00356-9 | |||
CHEMBL59985 | 207469 | 0 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 570 | 8 | 2 | 3 | 7.2 | CC(Cc1ccc2c(c1)C(C)(C)CCC2(C)C)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 | 10.1016/S0960-894X(97)00356-9 | |||
10530400 | 126113 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 535 | 7 | 3 | 5 | 5.0 | COC(=O)C1(NC(=O)[C@@](C)(Cc2c[nH]c3ccccc23)NC(=O)OC2C3CC4CC(C3)CC2C4)CCCCC1 | 10.1021/jm970065l | |||
CHEMBL344220 | 126113 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 535 | 7 | 3 | 5 | 5.0 | COC(=O)C1(NC(=O)[C@@](C)(Cc2c[nH]c3ccccc23)NC(=O)OC2C3CC4CC(C3)CC2C4)CCCCC1 | 10.1021/jm970065l | |||
14208235 | 109917 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 442 | 4 | 3 | 4 | 3.9 | COc1ccc2[nH]c(C(=O)NC3N=C(c4ccccc4F)c4ccccc4NC3=O)cc2c1 | 10.1021/jm00047a021 | |||
CHEMBL307878 | 109917 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 442 | 4 | 3 | 4 | 3.9 | COc1ccc2[nH]c(C(=O)NC3N=C(c4ccccc4F)c4ccccc4NC3=O)cc2c1 | 10.1021/jm00047a021 | |||
10746778 | 54334 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 646 | 8 | 2 | 6 | 5.2 | CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccc(N2CCOCC2)cc1 | 10.1021/jm950626d | |||
CHEMBL154615 | 54334 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 646 | 8 | 2 | 6 | 5.2 | CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccc(N2CCOCC2)cc1 | 10.1021/jm950626d | |||
14208201 | 211360 | 0 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 436 | 6 | 3 | 3 | 4.4 | O=C(CCCc1c[nH]c2ccccc12)NC1N=C(c2ccccc2)c2ccccc2NC1=O | 10.1021/jm00047a021 | |||
CHEMBL73110 | 211360 | 0 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 436 | 6 | 3 | 3 | 4.4 | O=C(CCCc1c[nH]c2ccccc12)NC1N=C(c2ccccc2)c2ccccc2NC1=O | 10.1021/jm00047a021 | |||
52942901 | 24909 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 556 | 8 | 1 | 6 | 5.9 | CC(C)N(Cc1ccccc1)C(=O)CN1C(=O)C(Nc2ccccc2)c2nnc(-c3ccccc3)n2-c2ccccc21 | 10.1016/j.bmcl.2010.08.115 | |||
CHEMBL1269261 | 24909 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 556 | 8 | 1 | 6 | 5.9 | CC(C)N(Cc1ccccc1)C(=O)CN1C(=O)C(Nc2ccccc2)c2nnc(-c3ccccc3)n2-c2ccccc21 | 10.1016/j.bmcl.2010.08.115 | |||
54583298 | 68697 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 558 | 6 | 1 | 6 | 5.9 | COc1ccc(-c2cnc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2)cc1 | 10.1016/j.bmcl.2011.03.069 | |||
CHEMBL1774042 | 68697 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 558 | 6 | 1 | 6 | 5.9 | COc1ccc(-c2cnc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2)cc1 | 10.1016/j.bmcl.2011.03.069 | |||
10079035 | 170640 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 796 | 21 | 8 | 7 | 2.9 | CCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00028a015 | |||
CHEMBL420667 | 170640 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 796 | 21 | 8 | 7 | 2.9 | CCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00028a015 | |||
5311201 | 214174 | 35 | None | -2570 | 6 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00164a020 | |||
CHEMBL9387 | 214174 | 35 | None | -2570 | 6 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00164a020 | |||
10476766 | 109777 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 412 | 3 | 3 | 3 | 3.9 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1cc2ccccc2[nH]1 | 10.1021/jm00047a021 | |||
CHEMBL306806 | 109777 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 412 | 3 | 3 | 3 | 3.9 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1cc2ccccc2[nH]1 | 10.1021/jm00047a021 | |||
15667016 | 92893 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 960 | 25 | 9 | 11 | 1.0 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00094a001 | |||
CHEMBL2310856 | 92893 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 960 | 25 | 9 | 11 | 1.0 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00094a001 | |||
10476766 | 109777 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 412 | 3 | 3 | 3 | 3.9 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1cc2ccccc2[nH]1 | 10.1021/jm00120a002 | |||
CHEMBL306806 | 109777 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 412 | 3 | 3 | 3 | 3.9 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1cc2ccccc2[nH]1 | 10.1021/jm00120a002 | |||
10008654 | 134394 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 595 | 6 | 3 | 5 | 5.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3cccc4ccccc34)C(=O)C[C@@H]12 | 10.1021/jm0501127 | |||
CHEMBL366344 | 134394 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 595 | 6 | 3 | 5 | 5.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3cccc4ccccc34)C(=O)C[C@@H]12 | 10.1021/jm0501127 | |||
44348650 | 119883 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 986 | 24 | 11 | 11 | 2.0 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1cccc(NC(=O)[C@H](Cc2ccc(S(=O)(=O)O)cc2)NC(=O)O)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00099a005 | |||
CHEMBL331408 | 119883 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 986 | 24 | 11 | 11 | 2.0 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1cccc(NC(=O)[C@H](Cc2ccc(S(=O)(=O)O)cc2)NC(=O)O)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00099a005 | |||
10011110 | 168108 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 948 | 24 | 8 | 7 | 5.7 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(c1ccccc1)c1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00028a015 | |||
CHEMBL412544 | 168108 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 948 | 24 | 8 | 7 | 5.7 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(c1ccccc1)c1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00028a015 | |||
44329343 | 119107 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 556 | 7 | 3 | 4 | 5.6 | COc1ccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)NC(C)(C)C)C2=O)cc1 | 10.1016/S0960-894X(01)80832-5 | |||
CHEMBL329286 | 119107 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 556 | 7 | 3 | 4 | 5.6 | COc1ccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)NC(C)(C)C)C2=O)cc1 | 10.1016/S0960-894X(01)80832-5 | |||
155546692 | 180421 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 1861 | 72 | 19 | 23 | 3.2 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL4534236 | 180421 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 1861 | 72 | 19 | 23 | 3.2 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
10454890 | 161921 | 1 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 421 | 3 | 1 | 3 | 4.0 | CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00047a021 | |||
CHEMBL40211 | 161921 | 1 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 421 | 3 | 1 | 3 | 4.0 | CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00047a021 | |||
10454890 | 161921 | 1 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 421 | 3 | 1 | 3 | 4.0 | CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL40211 | 161921 | 1 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 421 | 3 | 1 | 3 | 4.0 | CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL106722 | 215251 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | None | None | None | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00028a015 | |||||
24784941 | 196497 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 516 | 6 | 0 | 5 | 6.4 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
CHEMBL515616 | 196497 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 516 | 6 | 0 | 5 | 6.4 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
CHEMBL263155 | 217339 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)NC(C)(C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00100a033 | |||||
54587150 | 68638 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 515 | 5 | 0 | 6 | 5.6 | COc1ccc(-c2cnc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)cc1 | 10.1016/j.bmcl.2011.03.069 | |||
CHEMBL1773887 | 68638 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 515 | 5 | 0 | 6 | 5.6 | COc1ccc(-c2cnc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)cc1 | 10.1016/j.bmcl.2011.03.069 | |||
54580266 | 68639 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 529 | 6 | 0 | 6 | 6.0 | CCOc1ccc(-c2cnc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)cc1 | 10.1016/j.bmcl.2011.03.069 | |||
CHEMBL1773888 | 68639 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 529 | 6 | 0 | 6 | 6.0 | CCOc1ccc(-c2cnc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)cc1 | 10.1016/j.bmcl.2011.03.069 | |||
14208241 | 74525 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 421 | 3 | 1 | 3 | 4.0 | CN1C(=O)[C@@H](NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL1907852 | 74525 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 421 | 3 | 1 | 3 | 4.0 | CN1C(=O)[C@@H](NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
24784940 | 189566 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 502 | 5 | 0 | 5 | 6.0 | COc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
CHEMBL479046 | 189566 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 502 | 5 | 0 | 5 | 6.0 | COc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
14208269 | 84601 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 447 | 3 | 1 | 3 | 4.0 | CN1C(=O)[C@@H](NC(=O)c2ccc(Br)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00047a021 | |||
CHEMBL2092869 | 84601 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 447 | 3 | 1 | 3 | 4.0 | CN1C(=O)[C@@H](NC(=O)c2ccc(Br)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00047a021 | |||
CHEMBL2079549 | 215971 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1ccc(CC(=O)O)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00107a037 | |||||
155551968 | 180796 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 1793 | 69 | 16 | 20 | 4.5 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL4542927 | 180796 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 1793 | 69 | 16 | 20 | 4.5 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
44348901 | 148606 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 1000 | 24 | 11 | 11 | 2.3 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1cccc(NC(=O)[C@H](Cc2ccc(S(=O)(=O)O)cc2)NC(=O)O)c1C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00099a005 | |||
CHEMBL386376 | 148606 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 1000 | 24 | 11 | 11 | 2.3 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1cccc(NC(=O)[C@H](Cc2ccc(S(=O)(=O)O)cc2)NC(=O)O)c1C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00099a005 | |||
44344743 | 170352 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 555 | 11 | 4 | 3 | 5.3 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)CC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccccc1 | 10.1021/jm000937a | |||
CHEMBL420320 | 170352 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 555 | 11 | 4 | 3 | 5.3 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)CC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccccc1 | 10.1021/jm000937a | |||
904 | 9800 | 10 | None | - | 1 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1016/S0960-894X(00)80685-X | |||
9915756 | 9800 | 10 | None | - | 1 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1016/S0960-894X(00)80685-X | |||
CHEMBL2111204 | 9800 | 10 | None | - | 1 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1016/S0960-894X(00)80685-X | |||
CHEMBL356898 | 9800 | 10 | None | - | 1 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1016/S0960-894X(00)80685-X | |||
904 | 9800 | 10 | None | - | 1 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1016/s0960-894x(98)00677-5 | |||
9915756 | 9800 | 10 | None | - | 1 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1016/s0960-894x(98)00677-5 | |||
CHEMBL2111204 | 9800 | 10 | None | - | 1 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1016/s0960-894x(98)00677-5 | |||
CHEMBL356898 | 9800 | 10 | None | - | 1 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1016/s0960-894x(98)00677-5 | |||
44329486 | 119376 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 544 | 6 | 3 | 3 | 5.7 | Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)C[C@H](c3ccc(F)cc3)N(CC(=O)NC(C)(C)C)C2=O)c1 | 10.1016/S0960-894X(01)80832-5 | |||
CHEMBL330197 | 119376 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 544 | 6 | 3 | 3 | 5.7 | Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)C[C@H](c3ccc(F)cc3)N(CC(=O)NC(C)(C)C)C2=O)c1 | 10.1016/S0960-894X(01)80832-5 | |||
904 | 9800 | 10 | None | - | 1 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1021/jm00057a005 | |||
9915756 | 9800 | 10 | None | - | 1 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1021/jm00057a005 | |||
CHEMBL2111204 | 9800 | 10 | None | - | 1 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1021/jm00057a005 | |||
CHEMBL356898 | 9800 | 10 | None | - | 1 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1021/jm00057a005 | |||
44398261 | 131164 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 577 | 7 | 4 | 6 | 4.2 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(S)N(Cc3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm0501127 | |||
CHEMBL363916 | 131164 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 577 | 7 | 4 | 6 | 4.2 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(S)N(Cc3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm0501127 | |||
11103804 | 122232 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 575 | 7 | 3 | 5 | 4.9 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(Cc3ccccc3)C(=S)C[C@@H]12 | 10.1021/jm010898i | |||
CHEMBL3350855 | 122232 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 575 | 7 | 3 | 5 | 4.9 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(Cc3ccccc3)C(=S)C[C@@H]12 | 10.1021/jm010898i | |||
14208241 | 74525 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 421 | 3 | 1 | 3 | 4.0 | CN1C(=O)[C@@H](NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00047a021 | |||
CHEMBL1907852 | 74525 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 421 | 3 | 1 | 3 | 4.0 | CN1C(=O)[C@@H](NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00047a021 | |||
10320031 | 84600 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 421 | 3 | 1 | 3 | 4.0 | CN1C(=O)[C@H](NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00121a004 | |||
CHEMBL2092868 | 84600 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 421 | 3 | 1 | 3 | 4.0 | CN1C(=O)[C@H](NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00121a004 | |||
14208269 | 84601 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 447 | 3 | 1 | 3 | 4.0 | CN1C(=O)[C@@H](NC(=O)c2ccc(Br)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL2092869 | 84601 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 447 | 3 | 1 | 3 | 4.0 | CN1C(=O)[C@@H](NC(=O)c2ccc(Br)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
10973734 | 85209 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 559 | 6 | 3 | 5 | 4.4 | Cc1ccc(N2C(=O)C[C@H]3[C@H](NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)OC(C)(C)C)CCCN3C2=O)cc1 | 10.1021/jm010813d | |||
CHEMBL2111549 | 85209 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 559 | 6 | 3 | 5 | 4.4 | Cc1ccc(N2C(=O)C[C@H]3[C@H](NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)OC(C)(C)C)CCCN3C2=O)cc1 | 10.1021/jm010813d | |||
14991570 | 209594 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 943 | 22 | 9 | 11 | 3.2 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1ccc2cc(OS(=O)(=O)O)ccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
CHEMBL62345 | 209594 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 943 | 22 | 9 | 11 | 3.2 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1ccc2cc(OS(=O)(=O)O)ccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
44382008 | 65824 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 403 | 3 | 1 | 3 | 3.9 | CN1C(=O)[C@H](NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(00)80684-8 | |||
CHEMBL169438 | 65824 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 403 | 3 | 1 | 3 | 3.9 | CN1C(=O)[C@H](NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(00)80684-8 | |||
13503154 | 107043 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 363 | 9 | 4 | 6 | 0.1 | CSCC[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(N)=O | 10.1021/jm00378a012 | |||
CHEMBL288892 | 107043 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 363 | 9 | 4 | 6 | 0.1 | CSCC[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(N)=O | 10.1021/jm00378a012 | |||
72707158 | 147530 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 265 | 3 | 1 | 2 | 2.5 | CC(C)CN1C(=O)C=C(Cl)C1(O)c1ccccc1 | 10.1039/C6MD00052E | |||
CHEMBL3818215 | 147530 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 265 | 3 | 1 | 2 | 2.5 | CC(C)CN1C(=O)C=C(Cl)C1(O)c1ccccc1 | 10.1039/C6MD00052E | |||
14208271 | 109672 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 455 | 3 | 1 | 3 | 4.4 | CN1C(=O)C(NC(=O)c2ccc(C(F)(F)F)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL305951 | 109672 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 455 | 3 | 1 | 3 | 4.4 | CN1C(=O)C(NC(=O)c2ccc(C(F)(F)F)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
14208214 | 172027 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 405 | 3 | 2 | 3 | 4.4 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccc2ccccc2c1 | 10.1021/jm00120a002 | |||
CHEMBL422951 | 172027 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 405 | 3 | 2 | 3 | 4.4 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccc2ccccc2c1 | 10.1021/jm00120a002 | |||
10074366 | 127376 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 491 | 9 | 4 | 4 | 4.5 | C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
CHEMBL3349028 | 127376 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 491 | 9 | 4 | 4 | 4.5 | C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
CHEMBL3545866 | 127376 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 491 | 9 | 4 | 4 | 4.5 | C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
46235271 | 80423 | 2 | None | 2 | 2 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 649 | 7 | 1 | 6 | 6.7 | Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1016/j.bmcl.2012.02.049 | |||
CHEMBL2017835 | 80423 | 2 | None | 2 | 2 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 649 | 7 | 1 | 6 | 6.7 | Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1016/j.bmcl.2012.02.049 | |||
14208249 | 211411 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 387 | 3 | 2 | 3 | 3.7 | Cc1ccc(C(=O)NC2N=C(c3ccccc3F)c3ccccc3NC2=O)cc1 | 10.1021/jm00047a021 | |||
CHEMBL73510 | 211411 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 387 | 3 | 2 | 3 | 3.7 | Cc1ccc(C(=O)NC2N=C(c3ccccc3F)c3ccccc3NC2=O)cc1 | 10.1021/jm00047a021 | |||
10603714 | 163297 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 605 | 8 | 1 | 5 | 6.0 | COc1ccc(N(C(=O)CN2C(=O)C(Cc3n[nH]c4c(F)cccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm970265x | |||
CHEMBL406790 | 163297 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 605 | 8 | 1 | 5 | 6.0 | COc1ccc(N(C(=O)CN2C(=O)C(Cc3n[nH]c4c(F)cccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm970265x | |||
367893 | 58394 | 1 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 429 | 14 | 3 | 3 | 4.3 | CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)O)NC(=O)c1cc2ccccc2[nH]1 | 10.1021/jm00124a003 | |||
CHEMBL158362 | 58394 | 1 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 429 | 14 | 3 | 3 | 4.3 | CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)O)NC(=O)c1cc2ccccc2[nH]1 | 10.1021/jm00124a003 | |||
13953692 | 108498 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 407 | 3 | 1 | 4 | 5.0 | Fc1ccccc1C1=N[C@H](Cc2c[nH]c3ccccc23)c2nncn2-c2ccccc21 | 10.1021/jm00396a028 | |||
CHEMBL299538 | 108498 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 407 | 3 | 1 | 4 | 5.0 | Fc1ccccc1C1=N[C@H](Cc2c[nH]c3ccccc23)c2nncn2-c2ccccc21 | 10.1021/jm00396a028 | |||
89913094 | 147559 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 251 | 2 | 1 | 2 | 2.2 | CC(C)N1C(=O)C=C(Cl)C1(O)c1ccccc1 | 10.1039/C6MD00052E | |||
CHEMBL3818578 | 147559 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 251 | 2 | 1 | 2 | 2.2 | CC(C)N1C(=O)C=C(Cl)C1(O)c1ccccc1 | 10.1039/C6MD00052E | |||
14208235 | 109917 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 442 | 4 | 3 | 4 | 3.9 | COc1ccc2[nH]c(C(=O)NC3N=C(c4ccccc4F)c4ccccc4NC3=O)cc2c1 | 10.1021/jm00120a002 | |||
CHEMBL307878 | 109917 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 442 | 4 | 3 | 4 | 3.9 | COc1ccc2[nH]c(C(=O)NC3N=C(c4ccccc4F)c4ccccc4NC3=O)cc2c1 | 10.1021/jm00120a002 | |||
11798691 | 65045 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 473 | 5 | 4 | 7 | 3.4 | CN1C(=O)[C@H](NC(=O)Nc2cccc(Nc3nn[nH]n3)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm9506736 | |||
CHEMBL168263 | 65045 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 473 | 5 | 4 | 7 | 3.4 | CN1C(=O)[C@H](NC(=O)Nc2cccc(Nc3nn[nH]n3)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm9506736 | |||
10962743 | 85372 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 559 | 6 | 3 | 5 | 4.4 | Cc1ccc(N2C(=O)C[C@@H]3[C@@H](NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)OC(C)(C)C)CCCN3C2=O)cc1 | 10.1021/jm010813d | |||
CHEMBL2112239 | 85372 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 559 | 6 | 3 | 5 | 4.4 | Cc1ccc(N2C(=O)C[C@@H]3[C@@H](NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)OC(C)(C)C)CCCN3C2=O)cc1 | 10.1021/jm010813d | |||
44370505 | 58054 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 543 | 10 | 2 | 4 | 6.3 | O=C(CC[C@H](NC(=O)c1cc2ccccc2[nH]1)C(=O)N(C1CCCCC1)C1CCCCC1)OCc1ccccc1 | 10.1021/jm00164a020 | |||
CHEMBL158078 | 58054 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 543 | 10 | 2 | 4 | 6.3 | O=C(CC[C@H](NC(=O)c1cc2ccccc2[nH]1)C(=O)N(C1CCCCC1)C1CCCCC1)OCc1ccccc1 | 10.1021/jm00164a020 | |||
10029582 | 33938 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 517 | 7 | 2 | 4 | 4.5 | CCN(CC)C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2Cl)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL136608 | 33938 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 517 | 7 | 2 | 4 | 4.5 | CCN(CC)C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2Cl)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
44356717 | 123558 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 513 | 5 | 3 | 5 | 4.7 | CN1C(=O)C(NC(=O)Nc2cccc(CNC(=O)OC(C)(C)C)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL337722 | 123558 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 513 | 5 | 3 | 5 | 4.7 | CN1C(=O)C(NC(=O)Nc2cccc(CNC(=O)OC(C)(C)C)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
44578531 | 179341 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 570 | 6 | 0 | 5 | 6.9 | Cc1ccc(-c2nc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)cn2-c2cccc(OCC(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2008.06.057 | |||
CHEMBL448597 | 179341 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 570 | 6 | 0 | 5 | 6.9 | Cc1ccc(-c2nc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)cn2-c2cccc(OCC(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2008.06.057 | |||
44334332 | 115663 | 0 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 574 | 10 | 3 | 4 | 5.6 | CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N1CCC(Cc2ccccc2)CC1 | 10.1016/0960-894X(95)00537-3 | |||
CHEMBL321072 | 115663 | 0 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 574 | 10 | 3 | 4 | 5.6 | CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N1CCC(Cc2ccccc2)CC1 | 10.1016/0960-894X(95)00537-3 | |||
44349028 | 124000 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 437 | 7 | 3 | 4 | 3.5 | O=C(O)CCC(NC(=O)c1ccc2ccccc2c1)C(=O)NN1CCC2(CCCC2)CC1 | 10.1021/jm00079a003 | |||
CHEMBL339453 | 124000 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 437 | 7 | 3 | 4 | 3.5 | O=C(O)CCC(NC(=O)c1ccc2ccccc2c1)C(=O)NN1CCC2(CCCC2)CC1 | 10.1021/jm00079a003 | |||
89913112 | 147580 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 257 | 1 | 1 | 2 | 2.1 | CN1C(=O)C=C(Cl)C1(O)c1ccc(Cl)cc1 | 10.1039/C6MD00052E | |||
CHEMBL3818822 | 147580 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 257 | 1 | 1 | 2 | 2.1 | CN1C(=O)C=C(Cl)C1(O)c1ccc(Cl)cc1 | 10.1039/C6MD00052E | |||
44280215 | 106606 | 0 | None | - | 1 | Mouse | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 756 | 15 | 6 | 10 | 3.3 | Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCC(=O)NCCSCc4csc(N=C(N)N)n4)c3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
CHEMBL285586 | 106606 | 0 | None | - | 1 | Mouse | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 756 | 15 | 6 | 10 | 3.3 | Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCC(=O)NCCSCc4csc(N=C(N)N)n4)c3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
44334379 | 115550 | 0 | None | - | 0 | Guinea pig | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 435 | 7 | 2 | 3 | 4.7 | Cc1cccc(NC(=O)N[C@H](CC(C)C)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
CHEMBL320901 | 115550 | 0 | None | - | 0 | Guinea pig | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 435 | 7 | 2 | 3 | 4.7 | Cc1cccc(NC(=O)N[C@H](CC(C)C)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
19766161 | 65957 | 0 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 403 | 4 | 3 | 3 | 3.4 | O=C(O)CN1C(=O)C(NC(=O)Nc2cccc3ccccc23)CCc2ccccc21 | 10.1016/S0960-894X(00)80683-6 | |||
CHEMBL170068 | 65957 | 0 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 403 | 4 | 3 | 3 | 3.4 | O=C(O)CN1C(=O)C(NC(=O)Nc2cccc3ccccc23)CCc2ccccc21 | 10.1016/S0960-894X(00)80683-6 | |||
14208201 | 211360 | 0 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 436 | 6 | 3 | 3 | 4.4 | O=C(CCCc1c[nH]c2ccccc12)NC1N=C(c2ccccc2)c2ccccc2NC1=O | 10.1021/jm00120a002 | |||
CHEMBL73110 | 211360 | 0 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 436 | 6 | 3 | 3 | 4.4 | O=C(CCCc1c[nH]c2ccccc12)NC1N=C(c2ccccc2)c2ccccc2NC1=O | 10.1021/jm00120a002 | |||
44356972 | 34429 | 0 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 555 | 7 | 3 | 7 | 3.3 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)ON3CCC[C@@H]3C(=O)O)C2=O)c1 | 10.1021/jm00078a018 | |||
CHEMBL136990 | 34429 | 0 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 555 | 7 | 3 | 7 | 3.3 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)ON3CCC[C@@H]3C(=O)O)C2=O)c1 | 10.1021/jm00078a018 | |||
52945789 | 25056 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 541 | 7 | 0 | 5 | 6.0 | CC(C)N(C(=O)CN1C(=O)C(Cc2ccccc2)c2nnc(-c3ccccc3)n2-c2ccccc21)c1ccccc1 | 10.1016/j.bmcl.2010.08.115 | |||
CHEMBL1270487 | 25056 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 541 | 7 | 0 | 5 | 6.0 | CC(C)N(C(=O)CN1C(=O)C(Cc2ccccc2)c2nnc(-c3ccccc3)n2-c2ccccc21)c1ccccc1 | 10.1016/j.bmcl.2010.08.115 | |||
2802894 | 9182 | 33 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 435 | 3 | 2 | 2 | 4.9 | Brc1ccc(cc1)NC(=O)N1NC(=O)[C@H]([C@@H]1c1ccccc1)c1ccccc1 | 10.1021/jm000937a | |||
3509 | 9182 | 33 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 435 | 3 | 2 | 2 | 4.9 | Brc1ccc(cc1)NC(=O)N1NC(=O)[C@H]([C@@H]1c1ccccc1)c1ccccc1 | 10.1021/jm000937a | |||
CHEMBL333081 | 9182 | 33 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 435 | 3 | 2 | 2 | 4.9 | Brc1ccc(cc1)NC(=O)N1NC(=O)[C@H]([C@@H]1c1ccccc1)c1ccccc1 | 10.1021/jm000937a | |||
2802894 | 9182 | 33 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 435 | 3 | 2 | 2 | 4.9 | Brc1ccc(cc1)NC(=O)N1NC(=O)[C@H]([C@@H]1c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(00)80684-8 | |||
3509 | 9182 | 33 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 435 | 3 | 2 | 2 | 4.9 | Brc1ccc(cc1)NC(=O)N1NC(=O)[C@H]([C@@H]1c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(00)80684-8 | |||
CHEMBL333081 | 9182 | 33 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 435 | 3 | 2 | 2 | 4.9 | Brc1ccc(cc1)NC(=O)N1NC(=O)[C@H]([C@@H]1c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(00)80684-8 | |||
45482487 | 205380 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 441 | 7 | 4 | 3 | 4.2 | Cc1c(C(=O)Nc2ccccc2C(=O)NC(Cc2ccccc2)C(=O)O)[nH]c2ccccc12 | 10.1016/j.bmc.2009.05.067 | |||
CHEMBL578652 | 205380 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 441 | 7 | 4 | 3 | 4.2 | Cc1c(C(=O)Nc2ccccc2C(=O)NC(Cc2ccccc2)C(=O)O)[nH]c2ccccc12 | 10.1016/j.bmc.2009.05.067 | |||
10768071 | 16606 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 512 | 6 | 3 | 5 | 4.3 | CC(C)(C)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C(=O)O)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm960669+ | |||
CHEMBL113988 | 16606 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 512 | 6 | 3 | 5 | 4.3 | CC(C)(C)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C(=O)O)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm960669+ | |||
44591977 | 185838 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 443 | 7 | 5 | 4 | 3.6 | O=C(Nc1ccccc1C(=O)NC(Cc1ccc(O)cc1)C(=O)O)c1cc2ccccc2[nH]1 | 10.1016/j.bmc.2009.02.012 | |||
CHEMBL471464 | 185838 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 443 | 7 | 5 | 4 | 3.6 | O=C(Nc1ccccc1C(=O)NC(Cc1ccc(O)cc1)C(=O)O)c1cc2ccccc2[nH]1 | 10.1016/j.bmc.2009.02.012 | |||
44349336 | 171293 | 0 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 455 | 7 | 3 | 4 | 3.6 | O=C(O)CCC(NC(=O)c1cccc(Cl)c1Cl)C(=O)NN1CCC2(CCCC2)CC1 | 10.1021/jm00079a003 | |||
CHEMBL421474 | 171293 | 0 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 455 | 7 | 3 | 4 | 3.6 | O=C(O)CCC(NC(=O)c1cccc(Cl)c1Cl)C(=O)NN1CCC2(CCCC2)CC1 | 10.1021/jm00079a003 | |||
10813333 | 112130 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 447 | 5 | 2 | 4 | 4.2 | CCCN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C([C@H]2CCCCN2C)c2ccccc21 | 10.1021/jm9608523 | |||
CHEMBL311638 | 112130 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 447 | 5 | 2 | 4 | 4.2 | CCCN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C([C@H]2CCCCN2C)c2ccccc21 | 10.1021/jm9608523 | |||
CHEMBL3142682 | 217906 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | None | None | None | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)NC1CCCCC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||||
52940616 | 24911 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 581 | 7 | 1 | 6 | 5.7 | CC(C)N(Cc1ccccc1)C(=O)CN1C(=O)C(c2n[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc21 | 10.1016/j.bmcl.2010.08.115 | |||
CHEMBL1269263 | 24911 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 581 | 7 | 1 | 6 | 5.7 | CC(C)N(Cc1ccccc1)C(=O)CN1C(=O)C(c2n[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc21 | 10.1016/j.bmcl.2010.08.115 | |||
14208249 | 211411 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 387 | 3 | 2 | 3 | 3.7 | Cc1ccc(C(=O)NC2N=C(c3ccccc3F)c3ccccc3NC2=O)cc1 | 10.1021/jm00120a002 | |||
CHEMBL73510 | 211411 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 387 | 3 | 2 | 3 | 3.7 | Cc1ccc(C(=O)NC2N=C(c3ccccc3F)c3ccccc3NC2=O)cc1 | 10.1021/jm00120a002 | |||
9914964 | 16403 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 530 | 13 | 4 | 5 | 5.7 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cc(O)c2cccc(O)c2n1 | 10.1021/jm00116a002 | |||
CHEMBL112682 | 16403 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 530 | 13 | 4 | 5 | 5.7 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cc(O)c2cccc(O)c2n1 | 10.1021/jm00116a002 | |||
44293892 | 168466 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 613 | 6 | 2 | 5 | 5.8 | CSc1cccc(NC(=O)NC2N=C(c3ccccc3F)c3cccc(C)c3N(CC(=O)N3CC4CCC(CC4)C3)C2=O)c1 | 10.1016/S0960-894X(96)00609-9 | |||
CHEMBL413267 | 168466 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 613 | 6 | 2 | 5 | 5.8 | CSc1cccc(NC(=O)NC2N=C(c3ccccc3F)c3cccc(C)c3N(CC(=O)N3CC4CCC(CC4)C3)C2=O)c1 | 10.1016/S0960-894X(96)00609-9 | |||
14888709 | 84025 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 1031 | 30 | 11 | 12 | 0.3 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@@H](Cc1ccc(CC(=O)O)cc1)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00107a037 | |||
CHEMBL2079603 | 84025 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 1031 | 30 | 11 | 12 | 0.3 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@@H](Cc1ccc(CC(=O)O)cc1)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00107a037 | |||
71449099 | 85589 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 414 | 4 | 3 | 4 | 3.0 | CN1C(=O)[C@H](NC(=O)NCc2cccc(O)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL2112751 | 85589 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 414 | 4 | 3 | 4 | 3.0 | CN1C(=O)[C@H](NC(=O)NCc2cccc(O)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
14991578 | 168494 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 824 | 21 | 8 | 9 | 2.7 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C/c1cccnc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
CHEMBL413548 | 168494 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 824 | 21 | 8 | 9 | 2.7 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C/c1cccnc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
14208203 | 121240 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 425 | 3 | 2 | 3 | 4.3 | CC1C(C(=O)NC2N=C(c3ccccc3F)c3ccccc3NC2=O)=Cc2ccccc21 | 10.1021/jm00047a021 | |||
CHEMBL333459 | 121240 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 425 | 3 | 2 | 3 | 4.3 | CC1C(C(=O)NC2N=C(c3ccccc3F)c3ccccc3NC2=O)=Cc2ccccc21 | 10.1021/jm00047a021 | |||
14888706 | 84026 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 1017 | 29 | 11 | 12 | 0.4 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@@H](Cc1ccc(C(=O)O)cc1)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00107a037 | |||
CHEMBL2079604 | 84026 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 1017 | 29 | 11 | 12 | 0.4 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@@H](Cc1ccc(C(=O)O)cc1)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00107a037 | |||
10455302 | 34772 | 2 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 429 | 4 | 2 | 5 | 3.6 | CN1C(=O)C(NC(=O)Nc2ccc([N+](=O)[O-])cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL137240 | 34772 | 2 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 429 | 4 | 2 | 5 | 3.6 | CN1C(=O)C(NC(=O)Nc2ccc([N+](=O)[O-])cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
19766170 | 65931 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 383 | 5 | 3 | 4 | 2.2 | COc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)O)C2=O)c1 | 10.1016/S0960-894X(00)80683-6 | |||
CHEMBL169931 | 65931 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 383 | 5 | 3 | 4 | 2.2 | COc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)O)C2=O)c1 | 10.1016/S0960-894X(00)80683-6 | |||
CHEMBL2370879 | 216720 | 0 | None | - | 0 | Guinea pig | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | None | None | None | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00105a068 | |||||
44356697 | 32394 | 1 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 456 | 5 | 2 | 5 | 3.4 | COC(=O)Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00078a018 | |||
CHEMBL135166 | 32394 | 1 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 456 | 5 | 2 | 5 | 3.4 | COC(=O)Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00078a018 | |||
9870046 | 33120 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 486 | 5 | 3 | 6 | 3.4 | O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(Cc2nn[nH]n2)C1=O | 10.1021/jm00078a018 | |||
CHEMBL135901 | 33120 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 486 | 5 | 3 | 6 | 3.4 | O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(Cc2nn[nH]n2)C1=O | 10.1021/jm00078a018 | |||
10005779 | 123442 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 489 | 6 | 3 | 4 | 3.8 | CCNC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL337065 | 123442 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 489 | 6 | 3 | 4 | 3.8 | CCNC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
44280214 | 114079 | 0 | None | - | 1 | Mouse | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 770 | 16 | 6 | 10 | 3.6 | Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCCC(=O)NCCSCc4csc(N=C(N)N)n4)c3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
CHEMBL31726 | 114079 | 0 | None | - | 1 | Mouse | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 770 | 16 | 6 | 10 | 3.6 | Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCCC(=O)NCCSCc4csc(N=C(N)N)n4)c3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
CHEMBL292097 | 217664 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/S0960-894X(01)81005-2 | |||||
5279366 | 110938 | 1 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 401 | 4 | 2 | 4 | 4.0 | CSc1ccc(C(=O)NC2N=C(c3ccccc3)c3ccccc3NC2=O)cc1 | 10.1021/jm00047a021 | |||
CHEMBL309575 | 110938 | 1 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 401 | 4 | 2 | 4 | 4.0 | CSc1ccc(C(=O)NC2N=C(c3ccccc3)c3ccccc3NC2=O)cc1 | 10.1021/jm00047a021 | |||
155564367 | 181935 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 1836 | 72 | 18 | 23 | 2.9 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL4570130 | 181935 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 1836 | 72 | 18 | 23 | 2.9 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
44303527 | 103264 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 632 | 12 | 5 | 5 | 5.0 | CC(Cc1c[nH]c2ccc(F)cc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1 | 10.1016/S0960-894X(97)00356-9 | |||
CHEMBL262456 | 103264 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 632 | 12 | 5 | 5 | 5.0 | CC(Cc1c[nH]c2ccc(F)cc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1 | 10.1016/S0960-894X(97)00356-9 | |||
136794946 | 113389 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 857 | 21 | 9 | 10 | 3.2 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1[N+](=O)[O-])C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||
15689731 | 113389 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 857 | 21 | 9 | 10 | 3.2 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1[N+](=O)[O-])C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||
CHEMBL3142903 | 113389 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 857 | 21 | 9 | 10 | 3.2 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1[N+](=O)[O-])C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||
136794946 | 113389 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 857 | 21 | 9 | 10 | 3.2 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1[N+](=O)[O-])C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm960509y | |||
15689731 | 113389 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 857 | 21 | 9 | 10 | 3.2 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1[N+](=O)[O-])C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm960509y | |||
CHEMBL3142903 | 113389 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 857 | 21 | 9 | 10 | 3.2 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1[N+](=O)[O-])C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm960509y | |||
3960 | 9124 | 23 | None | - | 1 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 458 | 14 | 2 | 3 | 5.2 | CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCCC | 10.1016/S0960-894X(00)80224-3 | |||
891 | 9124 | 23 | None | - | 1 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 458 | 14 | 2 | 3 | 5.2 | CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCCC | 10.1016/S0960-894X(00)80224-3 | |||
CHEMBL24938 | 9124 | 23 | None | - | 1 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 458 | 14 | 2 | 3 | 5.2 | CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCCC | 10.1016/S0960-894X(00)80224-3 | |||
44311642 | 210928 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 425 | 3 | 2 | 3 | 4.0 | CC1(C(=O)NC2N=C(c3ccccc3F)c3ccccc3NC2=O)C=Cc2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL70549 | 210928 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 425 | 3 | 2 | 3 | 4.0 | CC1(C(=O)NC2N=C(c3ccccc3F)c3ccccc3NC2=O)C=Cc2ccccc21 | 10.1021/jm00120a002 | |||
24784942 | 188122 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 488 | 4 | 1 | 5 | 5.7 | Cc1ccc(-c2nc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)cn2-c2cccc(O)c2)cc1 | 10.1016/j.bmcl.2008.06.057 | |||
CHEMBL476297 | 188122 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 488 | 4 | 1 | 5 | 5.7 | Cc1ccc(-c2nc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)cn2-c2cccc(O)c2)cc1 | 10.1016/j.bmcl.2008.06.057 | |||
90663975 | 113575 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 839 | 21 | 9 | 9 | 3.0 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1cccc(O)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
CHEMBL3144537 | 113575 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 839 | 21 | 9 | 9 | 3.0 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1cccc(O)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
44303224 | 148713 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 933 | 23 | 8 | 11 | 2.8 | CN(C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCNC(=O)/C=C/c1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
CHEMBL387073 | 148713 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 933 | 23 | 8 | 11 | 2.8 | CN(C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCNC(=O)/C=C/c1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
44348637 | 171289 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 966 | 27 | 11 | 11 | 1.0 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCNC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00099a005 | |||
CHEMBL421471 | 171289 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 966 | 27 | 11 | 11 | 1.0 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCNC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00099a005 | |||
52949124 | 7663 | 4 | None | -2 | 2 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
9055 | 7663 | 4 | None | -2 | 2 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
CHEMBL1269258 | 7663 | 4 | None | -2 | 2 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
DB12694 | 7663 | 4 | None | -2 | 2 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
10507071 | 120387 | 0 | None | - | 1 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 559 | 7 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm991078x | |||
CHEMBL332261 | 120387 | 0 | None | - | 1 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 559 | 7 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm991078x | |||
44396744 | 130824 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 516 | 7 | 2 | 5 | 4.4 | CC(C)(C)OC(=O)[C@H](Cc1c[nH]c2ccccc12)N[C@@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)CC12 | 10.1021/jm0498755 | |||
CHEMBL363106 | 130824 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 516 | 7 | 2 | 5 | 4.4 | CC(C)(C)OC(=O)[C@H](Cc1c[nH]c2ccccc12)N[C@@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)CC12 | 10.1021/jm0498755 | |||
10626665 | 17033 | 0 | None | - | 1 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 559 | 7 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@H]12 | 10.1021/jm010898i | |||
CHEMBL116127 | 17033 | 0 | None | - | 1 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 559 | 7 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@H]12 | 10.1021/jm010898i | |||
10626665 | 17033 | 0 | None | - | 1 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 559 | 7 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@H]12 | 10.1021/jm010813d | |||
CHEMBL116127 | 17033 | 0 | None | - | 1 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 559 | 7 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@H]12 | 10.1021/jm010813d | |||
5311148 | 8677 | 7 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 587 | 8 | 1 | 5 | 5.9 | COc1ccc(cc1)N(C(=O)CN1C(=O)C(Cc2[nH]nc3c2cccc3)C(=O)N(c2c1cccc2)c1ccccc1)C(C)C | 10.1021/jm960249k | |||
865 | 8677 | 7 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 587 | 8 | 1 | 5 | 5.9 | COc1ccc(cc1)N(C(=O)CN1C(=O)C(Cc2[nH]nc3c2cccc3)C(=O)N(c2c1cccc2)c1ccccc1)C(C)C | 10.1021/jm960249k | |||
CHEMBL293226 | 8677 | 7 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 587 | 8 | 1 | 5 | 5.9 | COc1ccc(cc1)N(C(=O)CN1C(=O)C(Cc2[nH]nc3c2cccc3)C(=O)N(c2c1cccc2)c1ccccc1)C(C)C | 10.1021/jm960249k | |||
5311148 | 8677 | 7 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 587 | 8 | 1 | 5 | 5.9 | COc1ccc(cc1)N(C(=O)CN1C(=O)C(Cc2[nH]nc3c2cccc3)C(=O)N(c2c1cccc2)c1ccccc1)C(C)C | 10.1021/jm970265x | |||
865 | 8677 | 7 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 587 | 8 | 1 | 5 | 5.9 | COc1ccc(cc1)N(C(=O)CN1C(=O)C(Cc2[nH]nc3c2cccc3)C(=O)N(c2c1cccc2)c1ccccc1)C(C)C | 10.1021/jm970265x | |||
CHEMBL293226 | 8677 | 7 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 587 | 8 | 1 | 5 | 5.9 | COc1ccc(cc1)N(C(=O)CN1C(=O)C(Cc2[nH]nc3c2cccc3)C(=O)N(c2c1cccc2)c1ccccc1)C(C)C | 10.1021/jm970265x | |||
44300891 | 206333 | 0 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 586 | 7 | 4 | 6 | 5.1 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(-c3nn[nH]n3)c1)C[C@@H]2CC1CCCCC1 | 10.1016/0960-894X(95)00327-P | |||
CHEMBL59234 | 206333 | 0 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 586 | 7 | 4 | 6 | 5.1 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(-c3nn[nH]n3)c1)C[C@@H]2CC1CCCCC1 | 10.1016/0960-894X(95)00327-P | |||
CHEMBL3142698 | 217913 | 0 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | None | None | None | Cc1ccccc1/N=C(/S)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||||
10075014 | 169760 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 508 | 6 | 2 | 5 | 4.4 | CCOC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00121a004 | |||
CHEMBL417521 | 169760 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 508 | 6 | 2 | 5 | 4.4 | CCOC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00121a004 | |||
13822924 | 108721 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 427 | 4 | 1 | 6 | 4.2 | O=C(NC1N=C(c2ccccc2F)c2ccccc2-n2cnnc21)OCc1ccccc1 | 10.1021/jm00396a028 | |||
CHEMBL301172 | 108721 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 427 | 4 | 1 | 6 | 4.2 | O=C(NC1N=C(c2ccccc2F)c2ccccc2-n2cnnc21)OCc1ccccc1 | 10.1021/jm00396a028 | |||
5279366 | 110938 | 1 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 401 | 4 | 2 | 4 | 4.0 | CSc1ccc(C(=O)NC2N=C(c3ccccc3)c3ccccc3NC2=O)cc1 | 10.1021/jm00120a002 | |||
CHEMBL309575 | 110938 | 1 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 401 | 4 | 2 | 4 | 4.0 | CSc1ccc(C(=O)NC2N=C(c3ccccc3)c3ccccc3NC2=O)cc1 | 10.1021/jm00120a002 | |||
10078285 | 128285 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 680 | 12 | 3 | 6 | 5.7 | C[Si](C)(C)CCOC(=O)C[C@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@H]2C[C@H](NC(=O)OCc3ccccc3)C(=O)N12 | 10.1016/s0960-894x(98)00677-5 | |||
CHEMBL358334 | 128285 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 680 | 12 | 3 | 6 | 5.7 | C[Si](C)(C)CCOC(=O)C[C@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@H]2C[C@H](NC(=O)OCc3ccccc3)C(=O)N12 | 10.1016/s0960-894x(98)00677-5 | |||
10075014 | 169760 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 508 | 6 | 2 | 5 | 4.4 | CCOC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL417521 | 169760 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 508 | 6 | 2 | 5 | 4.4 | CCOC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00078a018 | |||
90663983 | 113590 | 0 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 891 | 21 | 8 | 8 | 4.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(C(F)(F)F)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
CHEMBL3144552 | 113590 | 0 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 891 | 21 | 8 | 8 | 4.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(C(F)(F)F)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
3960 | 9124 | 23 | None | - | 1 | Guinea pig | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 458 | 14 | 2 | 3 | 5.2 | CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCCC | 10.1021/jm00164a020 | |||
891 | 9124 | 23 | None | - | 1 | Guinea pig | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 458 | 14 | 2 | 3 | 5.2 | CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCCC | 10.1021/jm00164a020 | |||
CHEMBL24938 | 9124 | 23 | None | - | 1 | Guinea pig | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 458 | 14 | 2 | 3 | 5.2 | CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCCC | 10.1021/jm00164a020 | |||
19766234 | 39110 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 427 | 4 | 1 | 3 | 5.6 | CN1c2ccccc2C(c2ccccc2F)=NCC1CNc1cccc(C(F)(F)F)c1 | 10.1021/jm00163a069 | |||
CHEMBL141051 | 39110 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 427 | 4 | 1 | 3 | 5.6 | CN1c2ccccc2C(c2ccccc2F)=NCC1CNc1cccc(C(F)(F)F)c1 | 10.1021/jm00163a069 | |||
10319892 | 65865 | 2 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 418 | 3 | 2 | 3 | 4.3 | CN1C(=O)[C@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL169661 | 65865 | 2 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 418 | 3 | 2 | 3 | 4.3 | CN1C(=O)[C@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
44334250 | 11368 | 0 | None | - | 0 | Guinea pig | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 514 | 9 | 3 | 4 | 4.6 | Cc1cccc(NC(=O)N[C@H](COCc2ccccc2)C(=O)N2CCCC(C(=O)Nc3ccccc3)C2)c1 | 10.1016/0960-894X(95)00537-3 | |||
CHEMBL102703 | 11368 | 0 | None | - | 0 | Guinea pig | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 514 | 9 | 3 | 4 | 4.6 | Cc1cccc(NC(=O)N[C@H](COCc2ccccc2)C(=O)N2CCCC(C(=O)Nc3ccccc3)C2)c1 | 10.1016/0960-894X(95)00537-3 | |||
44334434 | 11863 | 0 | None | - | 0 | Guinea pig | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 483 | 8 | 2 | 3 | 5.2 | Cc1cccc(NC(=O)N[C@H](CCc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
CHEMBL105527 | 11863 | 0 | None | - | 0 | Guinea pig | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 483 | 8 | 2 | 3 | 5.2 | Cc1cccc(NC(=O)N[C@H](CCc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
13953696 | 108739 | 0 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 483 | 4 | 1 | 4 | 6.7 | Fc1ccccc1C1=N[C@H](Cc2c[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc21 | 10.1021/jm00396a028 | |||
CHEMBL301331 | 108739 | 0 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 483 | 4 | 1 | 4 | 6.7 | Fc1ccccc1C1=N[C@H](Cc2c[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc21 | 10.1021/jm00396a028 | |||
15104615 | 179528 | 0 | None | - | 0 | Guinea pig | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 545 | 13 | 2 | 4 | 6.1 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)S(=O)(=O)c1ccc(Cl)cc1 | 10.1021/jm00116a002 | |||
CHEMBL450883 | 179528 | 0 | None | - | 0 | Guinea pig | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 545 | 13 | 2 | 4 | 6.1 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)S(=O)(=O)c1ccc(Cl)cc1 | 10.1021/jm00116a002 | |||
15614749 | 39019 | 0 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 393 | 4 | 2 | 4 | 3.5 | O=C(NCC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccsc1 | 10.1021/jm00163a069 | |||
CHEMBL140984 | 39019 | 0 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 393 | 4 | 2 | 4 | 3.5 | O=C(NCC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccsc1 | 10.1021/jm00163a069 | |||
20063245 | 122120 | 0 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 417 | 5 | 2 | 4 | 3.9 | O=C(NCC1N=C(c2ccccc2F)c2ccccc2NC1=O)OCc1ccccc1 | 10.1021/jm00163a069 | |||
CHEMBL334933 | 122120 | 0 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 417 | 5 | 2 | 4 | 3.9 | O=C(NCC1N=C(c2ccccc2F)c2ccccc2NC1=O)OCc1ccccc1 | 10.1021/jm00163a069 | |||
44349011 | 123638 | 0 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 373 | 8 | 4 | 3 | 2.7 | CC(C)(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1cc2ccccc2[nH]1 | 10.1021/jm00079a003 | |||
CHEMBL338134 | 123638 | 0 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 373 | 8 | 4 | 3 | 2.7 | CC(C)(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1cc2ccccc2[nH]1 | 10.1021/jm00079a003 | |||
10555387 | 36867 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 589 | 10 | 3 | 3 | 7.0 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC(Cc1ccccc1)Cc1ccccc1 | 10.1021/jm970065l | |||
CHEMBL138952 | 36867 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 589 | 10 | 3 | 3 | 7.0 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC(Cc1ccccc1)Cc1ccccc1 | 10.1021/jm970065l | |||
10720107 | 213462 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 497 | 6 | 3 | 6 | 5.3 | CC(C)Oc1cccc(-n2c(NNC(=O)Nc3cccc(C(F)(F)F)c3)nc3ccccc3c2=O)c1 | 10.1021/jm970373j | |||
CHEMBL8954 | 213462 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 497 | 6 | 3 | 6 | 5.3 | CC(C)Oc1cccc(-n2c(NNC(=O)Nc3cccc(C(F)(F)F)c3)nc3ccccc3c2=O)c1 | 10.1021/jm970373j | |||
44361556 | 123499 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 571 | 4 | 2 | 5 | 4.3 | CC(C)(C)OC(=O)N1Cc2[nH]c3ccccc3c2CC1C(=O)N[C@@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@H]12 | 10.1021/jm991078x | |||
CHEMBL337362 | 123499 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 571 | 4 | 2 | 5 | 4.3 | CC(C)(C)OC(=O)N1Cc2[nH]c3ccccc3c2CC1C(=O)N[C@@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@H]12 | 10.1021/jm991078x | |||
10032956 | 174815 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 742 | 17 | 7 | 6 | 5.8 | Cc1ccccc1NC(=O)NCCCC[C@H](CNC(=O)[C@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3)NC(=O)CCC(=O)O | 10.1021/jm00017a022 | |||
CHEMBL432258 | 174815 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 742 | 17 | 7 | 6 | 5.8 | Cc1ccccc1NC(=O)NCCCC[C@H](CNC(=O)[C@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3)NC(=O)CCC(=O)O | 10.1021/jm00017a022 | |||
15689730 | 113373 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 854 | 21 | 9 | 8 | 4.4 | CC(C)c1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||
CHEMBL3142694 | 113373 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 854 | 21 | 9 | 8 | 4.4 | CC(C)c1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||
CHEMBL100609 | 215231 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | None | None | None | COc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||||
CHEMBL100609 | 215231 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | None | None | None | COc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm960509y | |||||
CHEMBL100609 | 215231 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | None | None | None | COc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00173a006 | |||||
15667017 | 214955 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 974 | 28 | 10 | 11 | 1.7 | CCCC[C@H](NC(=O)/C=C/c1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00094a001 | |||
CHEMBL98332 | 214955 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 974 | 28 | 10 | 11 | 1.7 | CCCC[C@H](NC(=O)/C=C/c1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00094a001 | |||
15104594 | 16895 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 498 | 13 | 2 | 3 | 6.3 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cnc2ccccc2c1 | 10.1021/jm00116a002 | |||
CHEMBL115656 | 16895 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 498 | 13 | 2 | 3 | 6.3 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cnc2ccccc2c1 | 10.1021/jm00116a002 | |||
CHEMBL2370119 | 216564 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)C(Cc1cccc(CC(=O)O)c1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00107a037 | |||||
52949124 | 7663 | 4 | None | -2 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1016/j.bmcl.2012.02.049 | |||
9055 | 7663 | 4 | None | -2 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1016/j.bmcl.2012.02.049 | |||
CHEMBL1269258 | 7663 | 4 | None | -2 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1016/j.bmcl.2012.02.049 | |||
DB12694 | 7663 | 4 | None | -2 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1016/j.bmcl.2012.02.049 | |||
CHEMBL3142687 | 217909 | 0 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | None | None | None | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)NCc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||||
5311201 | 214174 | 35 | None | 26 | 6 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00092a007 | |||
CHEMBL9387 | 214174 | 35 | None | 26 | 6 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00092a007 | |||
5311201 | 214174 | 35 | None | 26 | 6 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00105a062 | |||
CHEMBL9387 | 214174 | 35 | None | 26 | 6 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00105a062 | |||
44382244 | 65969 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 618 | 11 | 4 | 4 | 6.4 | O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1)Nc1ccccc1 | 10.1016/S0960-894X(00)80687-3 | |||
CHEMBL170129 | 65969 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 618 | 11 | 4 | 4 | 6.4 | O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1)Nc1ccccc1 | 10.1016/S0960-894X(00)80687-3 | |||
367893 | 58394 | 1 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 429 | 14 | 3 | 3 | 4.3 | CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)O)NC(=O)c1cc2ccccc2[nH]1 | 10.1021/jm00164a020 | |||
CHEMBL158362 | 58394 | 1 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 429 | 14 | 3 | 3 | 4.3 | CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)O)NC(=O)c1cc2ccccc2[nH]1 | 10.1021/jm00164a020 | |||
5311201 | 214174 | 35 | None | 26 | 6 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00057a005 | |||
CHEMBL9387 | 214174 | 35 | None | 26 | 6 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00057a005 | |||
9828961 | 174765 | 0 | None | - | 0 | Guinea pig | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 548 | 6 | 4 | 4 | 5.2 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)O)c1)C[C@@H]2C1CCCCC1 | 10.1016/0960-894X(95)00327-P | |||
CHEMBL431919 | 174765 | 0 | None | - | 0 | Guinea pig | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 548 | 6 | 4 | 4 | 5.2 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)O)c1)C[C@@H]2C1CCCCC1 | 10.1016/0960-894X(95)00327-P | |||
10046475 | 122285 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 399 | 3 | 2 | 4 | 3.4 | Cc1cccc(NC(=O)NC2N=C(c3cccnc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00078a018 | |||
CHEMBL335241 | 122285 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 399 | 3 | 2 | 4 | 3.4 | Cc1cccc(NC(=O)NC2N=C(c3cccnc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00078a018 | |||
44349087 | 125227 | 0 | None | - | 0 | Rat | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 420 | 7 | 3 | 3 | 3.8 | O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NC1CCC2CCCCC2C1 | 10.1021/jm00079a003 | |||
CHEMBL341143 | 125227 | 0 | None | - | 0 | Rat | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 420 | 7 | 3 | 3 | 3.8 | O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NC1CCC2CCCCC2C1 | 10.1021/jm00079a003 | |||
15167776 | 74490 | 0 | None | - | 0 | Guinea pig | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 441 | 5 | 2 | 3 | 4.2 | O=C(O)CN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00390a019 | |||
CHEMBL1907728 | 74490 | 0 | None | - | 0 | Guinea pig | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 441 | 5 | 2 | 3 | 4.2 | O=C(O)CN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00390a019 | |||
15282007 | 175087 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 472 | 5 | 3 | 5 | 3.7 | Cc1cccc(NC(=O)NC2N=C(c3c[nH]cn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1016/0960-894X(95)00557-A | |||
CHEMBL434126 | 175087 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 472 | 5 | 3 | 5 | 3.7 | Cc1cccc(NC(=O)NC2N=C(c3c[nH]cn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1016/0960-894X(95)00557-A | |||
44336539 | 11916 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 563 | 7 | 2 | 5 | 4.6 | COc1ccc(N(C)C(=O)CN2C(=O)C(NC(=O)Nc3ccccc3)C(=O)N(c3ccccc3)c3ccccc32)cc1 | 10.1016/j.bmcl.2015.03.051 | |||
CHEMBL105775 | 11916 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 563 | 7 | 2 | 5 | 4.6 | COc1ccc(N(C)C(=O)CN2C(=O)C(NC(=O)Nc3ccccc3)C(=O)N(c3ccccc3)c3ccccc32)cc1 | 10.1016/j.bmcl.2015.03.051 | |||
10838217 | 214113 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 473 | 7 | 3 | 8 | 3.7 | CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(OC)c2)c1 | 10.1021/jm970373j | |||
CHEMBL9354 | 214113 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 473 | 7 | 3 | 8 | 3.7 | CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(OC)c2)c1 | 10.1021/jm970373j | |||
44327420 | 118363 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 571 | 10 | 2 | 5 | 5.3 | COC(=O)CN(CCc1ccccc1)C(=O)[C@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1016/S0960-894X(01)80769-1 | |||
CHEMBL328213 | 118363 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 571 | 10 | 2 | 5 | 5.3 | COC(=O)CN(CCc1ccccc1)C(=O)[C@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1016/S0960-894X(01)80769-1 | |||
10438352 | 16571 | 0 | None | - | 1 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 588 | 8 | 3 | 6 | 3.9 | COC(=O)[C@@]1(Cc2ccccc2)C[C@@H]2[C@@H](NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)OC(C)(C)C)CCCN2C1=O | 10.1016/0960-894X(96)00160-6 | |||
CHEMBL113699 | 16571 | 0 | None | - | 1 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 588 | 8 | 3 | 6 | 3.9 | COC(=O)[C@@]1(Cc2ccccc2)C[C@@H]2[C@@H](NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)OC(C)(C)C)CCCN2C1=O | 10.1016/0960-894X(96)00160-6 | |||
44286821 | 174631 | 0 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 822 | 18 | 7 | 7 | 5.0 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N1CCC[C@H]1CC(=O)NC(Cc1ccccc1)C(N)=O | 10.1021/jm00037a005 | |||
CHEMBL430937 | 174631 | 0 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 822 | 18 | 7 | 7 | 5.0 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N1CCC[C@H]1CC(=O)NC(Cc1ccccc1)C(N)=O | 10.1021/jm00037a005 | |||
15104608 | 115604 | 0 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 498 | 13 | 2 | 3 | 6.3 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccc2ncccc2c1 | 10.1021/jm00116a002 | |||
CHEMBL320976 | 115604 | 0 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 498 | 13 | 2 | 3 | 6.3 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccc2ncccc2c1 | 10.1021/jm00116a002 | |||
14208260 | 108896 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 423 | 3 | 2 | 3 | 4.3 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccc(C(F)(F)F)cc1 | 10.1021/jm00047a021 | |||
CHEMBL302359 | 108896 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 423 | 3 | 2 | 3 | 4.3 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccc(C(F)(F)F)cc1 | 10.1021/jm00047a021 | |||
19754257 | 127155 | 1 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 340 | 3 | 3 | 2 | 4.3 | O=C(Cc1c[nH]c2ccccc12)Nc1cc2c3ccccc3nc-2c[nH]1 | 10.1016/S0960-894X(00)80682-4 | |||
CHEMBL353304 | 127155 | 1 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 340 | 3 | 3 | 2 | 4.3 | O=C(Cc1c[nH]c2ccccc12)Nc1cc2c3ccccc3nc-2c[nH]1 | 10.1016/S0960-894X(00)80682-4 | |||
52942901 | 24909 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 556 | 8 | 1 | 6 | 5.9 | CC(C)N(Cc1ccccc1)C(=O)CN1C(=O)C(Nc2ccccc2)c2nnc(-c3ccccc3)n2-c2ccccc21 | 10.1016/j.bmcl.2010.08.115 | |||
CHEMBL1269261 | 24909 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 556 | 8 | 1 | 6 | 5.9 | CC(C)N(Cc1ccccc1)C(=O)CN1C(=O)C(Nc2ccccc2)c2nnc(-c3ccccc3)n2-c2ccccc21 | 10.1016/j.bmcl.2010.08.115 | |||
44336539 | 11916 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 563 | 7 | 2 | 5 | 4.6 | COc1ccc(N(C)C(=O)CN2C(=O)C(NC(=O)Nc3ccccc3)C(=O)N(c3ccccc3)c3ccccc32)cc1 | 10.1016/j.bmcl.2015.03.051 | |||
CHEMBL105775 | 11916 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 563 | 7 | 2 | 5 | 4.6 | COc1ccc(N(C)C(=O)CN2C(=O)C(NC(=O)Nc3ccccc3)C(=O)N(c3ccccc3)c3ccccc32)cc1 | 10.1016/j.bmcl.2015.03.051 | |||
14208260 | 108896 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 423 | 3 | 2 | 3 | 4.3 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccc(C(F)(F)F)cc1 | 10.1021/jm00120a002 | |||
CHEMBL302359 | 108896 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 423 | 3 | 2 | 3 | 4.3 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccc(C(F)(F)F)cc1 | 10.1021/jm00120a002 | |||
10453004 | 32897 | 9 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 390 | 3 | 2 | 3 | 3.5 | CN1C(=O)C(NC(=O)NC2CCCCC2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL135618 | 32897 | 9 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 390 | 3 | 2 | 3 | 3.5 | CN1C(=O)C(NC(=O)NC2CCCCC2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
10482726 | 32913 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 551 | 7 | 3 | 4 | 5.0 | O=C(CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21)NCc1ccccc1 | 10.1021/jm00078a018 | |||
CHEMBL135638 | 32913 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 551 | 7 | 3 | 4 | 5.0 | O=C(CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21)NCc1ccccc1 | 10.1021/jm00078a018 | |||
44334704 | 11390 | 0 | None | - | 0 | Guinea pig | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 499 | 9 | 2 | 4 | 4.8 | Cc1cccc(NC(=O)N[C@H](COCc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
CHEMBL102862 | 11390 | 0 | None | - | 0 | Guinea pig | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 499 | 9 | 2 | 4 | 4.8 | Cc1cccc(NC(=O)N[C@H](COCc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
10552615 | 36086 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 477 | 6 | 3 | 3 | 5.5 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1CCCCC1 | 10.1021/jm970065l | |||
CHEMBL138311 | 36086 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 477 | 6 | 3 | 3 | 5.5 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1CCCCC1 | 10.1021/jm970065l | |||
44382805 | 65986 | 0 | None | - | 0 | Mouse | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 536 | 9 | 3 | 5 | 3.4 | CC(C)C[C@H](NC(=O)C(NC(=O)OC(C)(C)C)c1ccccc1)C(=O)N1CC(=O)N[C@@H](Cc2ccccc2)C1 | 10.1016/S0960-894X(01)80253-5 | |||
CHEMBL170197 | 65986 | 0 | None | - | 0 | Mouse | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 536 | 9 | 3 | 5 | 3.4 | CC(C)C[C@H](NC(=O)C(NC(=O)OC(C)(C)C)c1ccccc1)C(=O)N1CC(=O)N[C@@H](Cc2ccccc2)C1 | 10.1016/S0960-894X(01)80253-5 | |||
44359866 | 123316 | 0 | None | - | 0 | Rat | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 557 | 9 | 3 | 7 | 3.3 | CC(=O)NCSCC(NC(=O)OC(C)(C)C)C(=O)NCC1CN=C(c2ccccc2F)c2ccccc2N1C | 10.1021/jm00163a069 | |||
CHEMBL336256 | 123316 | 0 | None | - | 0 | Rat | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 557 | 9 | 3 | 7 | 3.3 | CC(=O)NCSCC(NC(=O)OC(C)(C)C)C(=O)NCC1CN=C(c2ccccc2F)c2ccccc2N1C | 10.1021/jm00163a069 | |||
10837829 | 105340 | 1 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 463 | 6 | 3 | 6 | 5.0 | CC(C)Oc1cccc(-n2c(NNC(=O)Nc3cccc(Cl)c3)nc3ccccc3c2=O)c1 | 10.1021/jm970373j | |||
CHEMBL276627 | 105340 | 1 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 463 | 6 | 3 | 6 | 5.0 | CC(C)Oc1cccc(-n2c(NNC(=O)Nc3cccc(Cl)c3)nc3ccccc3c2=O)c1 | 10.1021/jm970373j | |||
52946667 | 24912 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 580 | 7 | 1 | 5 | 6.3 | CC(C)N(Cc1ccccc1)C(=O)CN1C(=O)[C@H](c2c[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc21 | 10.1016/j.bmcl.2010.08.115 | |||
CHEMBL1269264 | 24912 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 580 | 7 | 1 | 5 | 6.3 | CC(C)N(Cc1ccccc1)C(=O)CN1C(=O)[C@H](c2c[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc21 | 10.1016/j.bmcl.2010.08.115 | |||
613843 | 211358 | 31 | None | - | 0 | Rat | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 250 | 1 | 0 | 2 | 2.5 | CN1C(=O)CN=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL73096 | 211358 | 31 | None | - | 0 | Rat | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 250 | 1 | 0 | 2 | 2.5 | CN1C(=O)CN=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL2372077 | 216962 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H]1CNC(=O)CNC(=O)[C@H](CCCCNCc2ccccc2)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1016/j.bmc.2007.05.067 | |||||
70685411 | 80412 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 606 | 6 | 1 | 5 | 6.8 | O=C1C(Cc2c[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc2N1CC(=O)N1CCCCC1c1ccccc1 | 10.1016/j.bmcl.2012.02.049 | |||
CHEMBL2017824 | 80412 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 606 | 6 | 1 | 5 | 6.8 | O=C1C(Cc2c[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc2N1CC(=O)N1CCCCC1c1ccccc1 | 10.1016/j.bmcl.2012.02.049 | |||
54581261 | 68637 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 529 | 6 | 0 | 6 | 6.0 | CCOc1cccc(-c2cnc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2011.03.069 | |||
CHEMBL1773886 | 68637 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 529 | 6 | 0 | 6 | 6.0 | CCOc1cccc(-c2cnc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2011.03.069 | |||
44348922 | 23013 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 992 | 25 | 11 | 11 | 1.4 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC1CCC[C@H]1NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00099a005 | |||
CHEMBL122438 | 23013 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 992 | 25 | 11 | 11 | 1.4 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC1CCC[C@H]1NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00099a005 | |||
903 | 9798 | 9 | None | - | 1 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1021/jm000937a | |||
9850711 | 9798 | 9 | None | - | 1 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1021/jm000937a | |||
CHEMBL138534 | 9798 | 9 | None | - | 1 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1021/jm000937a | |||
CHEMBL2111312 | 9798 | 9 | None | - | 1 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1021/jm000937a | |||
904 | 9800 | 10 | None | - | 1 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1016/S0960-894X(01)80769-1 | |||
9915756 | 9800 | 10 | None | - | 1 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1016/S0960-894X(01)80769-1 | |||
CHEMBL2111204 | 9800 | 10 | None | - | 1 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1016/S0960-894X(01)80769-1 | |||
CHEMBL356898 | 9800 | 10 | None | - | 1 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1016/S0960-894X(01)80769-1 | |||
903 | 9798 | 9 | None | - | 1 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1016/S0960-894X(00)80685-X | |||
9850711 | 9798 | 9 | None | - | 1 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1016/S0960-894X(00)80685-X | |||
CHEMBL138534 | 9798 | 9 | None | - | 1 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1016/S0960-894X(00)80685-X | |||
CHEMBL2111312 | 9798 | 9 | None | - | 1 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1016/S0960-894X(00)80685-X | |||
903 | 9798 | 9 | None | - | 1 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1021/jm00057a005 | |||
9850711 | 9798 | 9 | None | - | 1 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1021/jm00057a005 | |||
CHEMBL138534 | 9798 | 9 | None | - | 1 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1021/jm00057a005 | |||
CHEMBL2111312 | 9798 | 9 | None | - | 1 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1021/jm00057a005 | |||
903 | 9798 | 9 | None | - | 1 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1021/jm970065l | |||
9850711 | 9798 | 9 | None | - | 1 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1021/jm970065l | |||
CHEMBL138534 | 9798 | 9 | None | - | 1 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1021/jm970065l | |||
CHEMBL2111312 | 9798 | 9 | None | - | 1 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1021/jm970065l | |||
11714635 | 79242 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 717 | 10 | 6 | 6 | 3.7 | CC(C)(C)OC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1C[C@H]2c3[nH]c4ccccc4c3C[C@H](C(=O)N[C@@H](Cc3ccccc3)C(N)=O)N2C1=O | 10.1021/jm050689o | |||
CHEMBL198902 | 79242 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 717 | 10 | 6 | 6 | 3.7 | CC(C)(C)OC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1C[C@H]2c3[nH]c4ccccc4c3C[C@H](C(=O)N[C@@H](Cc3ccccc3)C(N)=O)N2C1=O | 10.1021/jm050689o | |||
44300889 | 107538 | 0 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 532 | 6 | 4 | 6 | 3.8 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(-c3nn[nH]n3)c1)C[C@@H]2C(C)C | 10.1016/0960-894X(95)00327-P | |||
CHEMBL292856 | 107538 | 0 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 532 | 6 | 4 | 6 | 3.8 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(-c3nn[nH]n3)c1)C[C@@H]2C(C)C | 10.1016/0960-894X(95)00327-P | |||
10507109 | 116004 | 0 | None | - | 2 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 561 | 7 | 2 | 4 | 5.3 | CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1016/s0960-894x(98)00548-4 | |||
CHEMBL321761 | 116004 | 0 | None | - | 2 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 561 | 7 | 2 | 4 | 5.3 | CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1016/s0960-894x(98)00548-4 | |||
44381593 | 127250 | 0 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 854 | 23 | 9 | 10 | 3.3 | CN(C(=O)[C@H](CC(=O)O)NNC[C@H](CCCCNC(=O)/C=C\c1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(N)=O | 10.1016/S0960-894X(00)80680-0 | |||
CHEMBL354171 | 127250 | 0 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 854 | 23 | 9 | 10 | 3.3 | CN(C(=O)[C@H](CC(=O)O)NNC[C@H](CCCCNC(=O)/C=C\c1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(N)=O | 10.1016/S0960-894X(00)80680-0 | |||
14208309 | 74461 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 439 | 7 | 1 | 3 | 5.0 | CCCCCc1ccc(C(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc1 | 10.1021/jm00120a002 | |||
CHEMBL1907664 | 74461 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 439 | 7 | 1 | 3 | 5.0 | CCCCCc1ccc(C(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc1 | 10.1021/jm00120a002 | |||
44370393 | 126422 | 0 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 492 | 14 | 2 | 3 | 5.4 | CCCCCN(CCCCC)C(=O)C(CCC(=O)N1CCCC1)NC(=O)Nc1ccc(Cl)cc1 | 10.1021/jm00164a020 | |||
CHEMBL346784 | 126422 | 0 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 492 | 14 | 2 | 3 | 5.4 | CCCCCN(CCCCC)C(=O)C(CCC(=O)N1CCCC1)NC(=O)Nc1ccc(Cl)cc1 | 10.1021/jm00164a020 | |||
14991541 | 113585 | 0 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 843 | 22 | 8 | 8 | 3.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCc1ccc(F)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
CHEMBL3144546 | 113585 | 0 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 843 | 22 | 8 | 8 | 3.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCc1ccc(F)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
10369442 | 115324 | 0 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 521 | 7 | 3 | 5 | 3.6 | Cc1cccc(NC(=O)N[C@H](COC(=O)N2CCCC2)C(=O)N2CCC(C(=O)Nc3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
CHEMBL320154 | 115324 | 0 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 521 | 7 | 3 | 5 | 3.6 | Cc1cccc(NC(=O)N[C@H](COC(=O)N2CCCC2)C(=O)N2CCC(C(=O)Nc3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
44367000 | 126474 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 494 | 6 | 2 | 4 | 5.1 | Cc1cccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 | 10.1016/0960-894X(95)00556-9 | |||
CHEMBL347329 | 126474 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 494 | 6 | 2 | 4 | 5.1 | Cc1cccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 | 10.1016/0960-894X(95)00556-9 | |||
89913427 | 147502 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 311 | 2 | 1 | 2 | 3.4 | O=C1C=C(Cl)C(O)(c2ccc(Cl)cc2)N1C1CCCC1 | 10.1039/C6MD00052E | |||
CHEMBL3817873 | 147502 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 311 | 2 | 1 | 2 | 3.4 | O=C1C=C(Cl)C(O)(c2ccc(Cl)cc2)N1C1CCCC1 | 10.1039/C6MD00052E | |||
89913617 | 147525 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 223 | 1 | 1 | 2 | 1.4 | CN1C(=O)C=C(Cl)C1(O)c1ccccc1 | 10.1039/C6MD00052E | |||
CHEMBL3818165 | 147525 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 223 | 1 | 1 | 2 | 1.4 | CN1C(=O)C=C(Cl)C1(O)c1ccccc1 | 10.1039/C6MD00052E | |||
71458029 | 85565 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 628 | 13 | 5 | 5 | 5.2 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCC[C@H](NC(=O)CCC(=O)O)c1ccccc1 | 10.1021/jm00105a062 | |||
CHEMBL2112692 | 85565 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 628 | 13 | 5 | 5 | 5.2 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCC[C@H](NC(=O)CCC(=O)O)c1ccccc1 | 10.1021/jm00105a062 | |||
15104620 | 118137 | 0 | None | - | 0 | Guinea pig | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 476 | 13 | 3 | 2 | 6.4 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)Nc1ccc(C)cc1 | 10.1021/jm00116a002 | |||
CHEMBL326979 | 118137 | 0 | None | - | 0 | Guinea pig | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 476 | 13 | 3 | 2 | 6.4 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)Nc1ccc(C)cc1 | 10.1021/jm00116a002 | |||
14802537 | 65857 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCC(=O)O)c1ccccc1 | 10.1016/S0960-894X(00)80685-X | |||
CHEMBL169615 | 65857 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCC(=O)O)c1ccccc1 | 10.1016/S0960-894X(00)80685-X | |||
10052234 | 74536 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 515 | 5 | 2 | 4 | 4.3 | O=C(Nc1ccc(Cl)cc1)N[C@H]1N=C(c2ccccc2)c2ccccc2N(CC(=O)N2CCCC2)C1=O | 10.1021/jm00078a018 | |||
CHEMBL1907927 | 74536 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 515 | 5 | 2 | 4 | 4.3 | O=C(Nc1ccc(Cl)cc1)N[C@H]1N=C(c2ccccc2)c2ccccc2N(CC(=O)N2CCCC2)C1=O | 10.1021/jm00078a018 | |||
44280115 | 114004 | 0 | None | - | 0 | Mouse | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 658 | 11 | 3 | 6 | 5.8 | CN1C(=O)[C@H](NC(=O)Nc2cccc(C(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00248-X | |||
CHEMBL31671 | 114004 | 0 | None | - | 0 | Mouse | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 658 | 11 | 3 | 6 | 5.8 | CN1C(=O)[C@H](NC(=O)Nc2cccc(C(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00248-X | |||
44329519 | 115064 | 0 | None | - | 0 | Guinea pig | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 594 | 6 | 3 | 3 | 6.6 | Cc1ccccc1[C@H]1C[C@@H](NC(=O)Nc2cccc(C(F)(F)F)c2)C(=O)N(CC(=O)NC(C)(C)C)[C@@H](c2ccccc2)C1 | 10.1016/S0960-894X(01)80832-5 | |||
CHEMBL319748 | 115064 | 0 | None | - | 0 | Guinea pig | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 594 | 6 | 3 | 3 | 6.6 | Cc1ccccc1[C@H]1C[C@@H](NC(=O)Nc2cccc(C(F)(F)F)c2)C(=O)N(CC(=O)NC(C)(C)C)[C@@H](c2ccccc2)C1 | 10.1016/S0960-894X(01)80832-5 | |||
44334259 | 11244 | 0 | None | - | 0 | Guinea pig | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 435 | 8 | 2 | 3 | 4.8 | CCCC[C@@H](NC(=O)Nc1cccc(C)c1)C(=O)N1CCC(C(=O)c2ccccc2)CC1 | 10.1016/0960-894X(95)00537-3 | |||
CHEMBL101803 | 11244 | 0 | None | - | 0 | Guinea pig | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 435 | 8 | 2 | 3 | 4.8 | CCCC[C@@H](NC(=O)Nc1cccc(C)c1)C(=O)N1CCC(C(=O)c2ccccc2)CC1 | 10.1016/0960-894X(95)00537-3 | |||
13953694 | 196147 | 0 | None | - | 0 | Rat | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 523 | 3 | 1 | 4 | 6.8 | Fc1ccccc1C1=N[C@H](Cc2c[nH]c3ccccc23)c2nnc(C(Cl)(Cl)Cl)n2-c2ccccc21 | 10.1021/jm00396a028 | |||
CHEMBL51280 | 196147 | 0 | None | - | 0 | Rat | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 523 | 3 | 1 | 4 | 6.8 | Fc1ccccc1C1=N[C@H](Cc2c[nH]c3ccccc23)c2nnc(C(Cl)(Cl)Cl)n2-c2ccccc21 | 10.1021/jm00396a028 | |||
44368567 | 175514 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 495 | 9 | 4 | 4 | 4.2 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1CCCCC1F)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
CHEMBL437039 | 175514 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 495 | 9 | 4 | 4 | 4.2 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1CCCCC1F)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
44365359 | 128066 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 546 | 12 | 3 | 5 | 4.5 | COc1ccc(N(C(=O)CN(C(=O)[C@@H](CCC(=O)O)NC(=O)Nc2ccccc2)c2ccccc2)C(C)C)cc1 | 10.1016/S0960-894X(97)00062-0 | |||
CHEMBL357983 | 128066 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 546 | 12 | 3 | 5 | 4.5 | COc1ccc(N(C(=O)CN(C(=O)[C@@H](CCC(=O)O)NC(=O)Nc2ccccc2)c2ccccc2)C(C)C)cc1 | 10.1016/S0960-894X(97)00062-0 | |||
44283246 | 106738 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 527 | 8 | 2 | 4 | 6.8 | O=C(NC(Cc1c[nH]c2ccccc12)C1CN=C(CCc2ccccc2)S1)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1021/jm00086a017 | |||
CHEMBL286442 | 106738 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 527 | 8 | 2 | 4 | 6.8 | O=C(NC(Cc1c[nH]c2ccccc12)C1CN=C(CCc2ccccc2)S1)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1021/jm00086a017 | |||
10722372 | 126359 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 605 | 8 | 3 | 5 | 5.0 | CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccc(C(=O)O)cc1 | 10.1021/jm950626d | |||
CHEMBL346179 | 126359 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 605 | 8 | 3 | 5 | 5.0 | CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccc(C(=O)O)cc1 | 10.1021/jm950626d | |||
CHEMBL1172251 | 215362 | 0 | None | -229 | 4 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/j.bmcl.2010.05.078 | |||||
44327698 | 214252 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 572 | 10 | 2 | 6 | 4.7 | COC(=O)CN(CCc1ccccn1)C(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1016/S0960-894X(01)80769-1 | |||
CHEMBL94298 | 214252 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 572 | 10 | 2 | 6 | 4.7 | COC(=O)CN(CCc1ccccn1)C(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1016/S0960-894X(01)80769-1 | |||
44348869 | 23179 | 0 | None | - | 0 | Rat | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 407 | 7 | 3 | 4 | 2.6 | O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NN1CCC2(CCCC2)C1 | 10.1021/jm00079a003 | |||
CHEMBL123089 | 23179 | 0 | None | - | 0 | Rat | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 407 | 7 | 3 | 4 | 2.6 | O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NN1CCC2(CCCC2)C1 | 10.1021/jm00079a003 | |||
9850184 | 117648 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 538 | 6 | 2 | 6 | 4.6 | CC(C)(C)C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(N3CCCC3)c2)N=C(c2ccccn2)c2ccccc21 | 10.1021/jm960669+ | |||
CHEMBL326102 | 117648 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 538 | 6 | 2 | 6 | 4.6 | CC(C)(C)C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(N3CCCC3)c2)N=C(c2ccccn2)c2ccccc21 | 10.1021/jm960669+ | |||
11154528 | 204715 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 426 | 7 | 3 | 3 | 3.7 | O=C(Nc1ccccc1C(=O)NC(Cc1ccccc1)C(=O)O)C1=Cc2ccccc2C1 | 10.1016/j.bmc.2009.05.067 | |||
CHEMBL573136 | 204715 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 426 | 7 | 3 | 3 | 3.7 | O=C(Nc1ccccc1C(=O)NC(Cc1ccccc1)C(=O)O)C1=Cc2ccccc2C1 | 10.1016/j.bmc.2009.05.067 | |||
44349391 | 123828 | 0 | None | - | 0 | Rat | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 422 | 9 | 3 | 3 | 4.2 | CCC1(CC)CCC(NC(=O)C(CCC(=O)O)NC(=O)c2cccc(Cl)c2)CC1 | 10.1021/jm00079a003 | |||
CHEMBL339115 | 123828 | 0 | None | - | 0 | Rat | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 422 | 9 | 3 | 3 | 4.2 | CCC1(CC)CCC(NC(=O)C(CCC(=O)O)NC(=O)c2cccc(Cl)c2)CC1 | 10.1021/jm00079a003 | |||
10814373 | 213882 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 474 | 7 | 3 | 8 | 4.2 | CC(C)Oc1cccc(-n2c(NNC(=O)Nc3cccc([N+](=O)[O-])c3)nc3ccccc3c2=O)c1 | 10.1021/jm970373j | |||
CHEMBL9203 | 213882 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 474 | 7 | 3 | 8 | 4.2 | CC(C)Oc1cccc(-n2c(NNC(=O)Nc3cccc([N+](=O)[O-])c3)nc3ccccc3c2=O)c1 | 10.1021/jm970373j | |||
11234811 | 205162 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 394 | 7 | 3 | 4 | 3.4 | O=C(Nc1ccccc1C(=O)NC(Cc1ccccc1)C(=O)O)c1cccs1 | 10.1016/j.bmc.2009.05.067 | |||
CHEMBL576731 | 205162 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 394 | 7 | 3 | 4 | 3.4 | O=C(Nc1ccccc1C(=O)NC(Cc1ccccc1)C(=O)O)c1cccs1 | 10.1016/j.bmc.2009.05.067 | |||
10005159 | 122186 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 475 | 5 | 3 | 4 | 5.4 | CN1C(=O)C(NC(=O)Nc2cccc(Nc3ccccc3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL335017 | 122186 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 475 | 5 | 3 | 4 | 5.4 | CN1C(=O)C(NC(=O)Nc2cccc(Nc3ccccc3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
10550527 | 214156 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 429 | 6 | 3 | 6 | 4.2 | CCOc1cccc(-n2c(NNC(=O)Nc3cccc(C)c3)nc3ccccc3c2=O)c1 | 10.1021/jm970373j | |||
CHEMBL9377 | 214156 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 429 | 6 | 3 | 6 | 4.2 | CCOc1cccc(-n2c(NNC(=O)Nc3cccc(C)c3)nc3ccccc3c2=O)c1 | 10.1021/jm970373j | |||
155517868 | 176990 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 1893 | 76 | 19 | 24 | 3.2 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL4445353 | 176990 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 1893 | 76 | 19 | 24 | 3.2 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
10027443 | 123310 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 464 | 5 | 3 | 4 | 4.3 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(Cc3ncc[nH]3)C2=O)c1 | 10.1021/jm00078a018 | |||
CHEMBL336221 | 123310 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 464 | 5 | 3 | 4 | 4.3 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(Cc3ncc[nH]3)C2=O)c1 | 10.1021/jm00078a018 | |||
44283246 | 106738 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 527 | 8 | 2 | 4 | 6.8 | O=C(NC(Cc1c[nH]c2ccccc12)C1CN=C(CCc2ccccc2)S1)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1021/jm00086a017 | |||
CHEMBL286442 | 106738 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 527 | 8 | 2 | 4 | 6.8 | O=C(NC(Cc1c[nH]c2ccccc12)C1CN=C(CCc2ccccc2)S1)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1021/jm00086a017 | |||
10649606 | 56390 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 519 | 6 | 3 | 4 | 4.5 | O=C(CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)Nc1ccccc1 | 10.1016/j.bmcl.2015.03.051 | |||
CHEMBL156605 | 56390 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 519 | 6 | 3 | 4 | 4.5 | O=C(CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)Nc1ccccc1 | 10.1016/j.bmcl.2015.03.051 | |||
15689733 | 113391 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 870 | 21 | 9 | 10 | 3.0 | COC(=O)c1cccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c1 | 10.1021/jm00113a023 | |||
CHEMBL3142905 | 113391 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 870 | 21 | 9 | 10 | 3.0 | COC(=O)c1cccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c1 | 10.1021/jm00113a023 | |||
CHEMBL319814 | 218002 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | None | None | None | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||||
44373740 | 126670 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 569 | 8 | 3 | 5 | 5.2 | COC(=O)[C@@]1(NC(=O)[C@@](C)(Cc2c[nH]c3ccccc23)NC(=O)OC2C3CC4CC(C3)CC2C4)C[C@H]1c1ccccc1 | 10.1016/S0960-894X(01)81250-6 | |||
CHEMBL349079 | 126670 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 569 | 8 | 3 | 5 | 5.2 | COC(=O)[C@@]1(NC(=O)[C@@](C)(Cc2c[nH]c3ccccc23)NC(=O)OC2C3CC4CC(C3)CC2C4)C[C@H]1c1ccccc1 | 10.1016/S0960-894X(01)81250-6 | |||
10070678 | 127533 | 1 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 418 | 3 | 2 | 3 | 4.3 | CN1C(=O)[C@@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00121a004 | |||
CHEMBL355092 | 127533 | 1 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 418 | 3 | 2 | 3 | 4.3 | CN1C(=O)[C@@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00121a004 | |||
CHEMBL319814 | 218002 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | None | None | None | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00173a006 | |||||
14888736 | 104862 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 974 | 29 | 10 | 11 | 1.2 | CSCC[C@H](NC(=O)CCc1ccc(CC(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00107a037 | |||
CHEMBL273344 | 104862 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 974 | 29 | 10 | 11 | 1.2 | CSCC[C@H](NC(=O)CCc1ccc(CC(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00107a037 | |||
10479056 | 32958 | 13 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 452 | 3 | 2 | 3 | 5.0 | CN1C(=O)C(NC(=O)Nc2ccc(Cl)c(Cl)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL135702 | 32958 | 13 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 452 | 3 | 2 | 3 | 5.0 | CN1C(=O)C(NC(=O)Nc2ccc(Cl)c(Cl)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
10070678 | 127533 | 1 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 418 | 3 | 2 | 3 | 4.3 | CN1C(=O)[C@@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(00)80682-4 | |||
CHEMBL355092 | 127533 | 1 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 418 | 3 | 2 | 3 | 4.3 | CN1C(=O)[C@@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(00)80682-4 | |||
44336539 | 11916 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 563 | 7 | 2 | 5 | 4.6 | COc1ccc(N(C)C(=O)CN2C(=O)C(NC(=O)Nc3ccccc3)C(=O)N(c3ccccc3)c3ccccc32)cc1 | 10.1016/j.bmcl.2015.03.051 | |||
CHEMBL105775 | 11916 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 563 | 7 | 2 | 5 | 4.6 | COc1ccc(N(C)C(=O)CN2C(=O)C(NC(=O)Nc3ccccc3)C(=O)N(c3ccccc3)c3ccccc32)cc1 | 10.1016/j.bmcl.2015.03.051 | |||
52949124 | 7663 | 4 | None | -2 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
9055 | 7663 | 4 | None | -2 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
CHEMBL1269258 | 7663 | 4 | None | -2 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
DB12694 | 7663 | 4 | None | -2 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
14519977 | 126727 | 0 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 429 | 14 | 3 | 3 | 4.3 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1c[nH]c2ccccc12 | 10.1021/jm00124a003 | |||
CHEMBL349640 | 126727 | 0 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 429 | 14 | 3 | 3 | 4.3 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1c[nH]c2ccccc12 | 10.1021/jm00124a003 | |||
44310001 | 210666 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 415 | 4 | 1 | 3 | 4.5 | Cc1ccc(C(=O)NC[C@H]2CN=C(c3ccc(F)cc3)c3ccc(C)cc3N2C)cc1 | 10.1021/jm00163a069 | |||
CHEMBL68870 | 210666 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 415 | 4 | 1 | 3 | 4.5 | Cc1ccc(C(=O)NC[C@H]2CN=C(c3ccc(F)cc3)c3ccc(C)cc3N2C)cc1 | 10.1021/jm00163a069 | |||
21842325 | 126900 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 495 | 6 | 2 | 5 | 4.5 | Cc1cccc(NC(=O)NC2N=C(c3ccccn3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 | 10.1016/0960-894X(95)00557-A | |||
CHEMBL351144 | 126900 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 495 | 6 | 2 | 5 | 4.5 | Cc1cccc(NC(=O)NC2N=C(c3ccccn3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 | 10.1016/0960-894X(95)00557-A | |||
135837528 | 127014 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 472 | 5 | 3 | 5 | 3.7 | Cc1cccc(NC(=O)NC2N=C(c3ncc[nH]3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1016/0960-894X(95)00557-A | |||
CHEMBL352217 | 127014 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 472 | 5 | 3 | 5 | 3.7 | Cc1cccc(NC(=O)NC2N=C(c3ncc[nH]3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1016/0960-894X(95)00557-A | |||
CHEMBL2372075 | 216960 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H]1CNC(=O)CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1016/j.bmc.2007.05.067 | |||||
10349938 | 169698 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 722 | 14 | 4 | 6 | 6.7 | CC(Cc1c[nH]c2ccc(F)cc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)OCc1ccccc1)c1ccccc1 | 10.1016/S0960-894X(97)00356-9 | |||
CHEMBL417412 | 169698 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 722 | 14 | 4 | 6 | 6.7 | CC(Cc1c[nH]c2ccc(F)cc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)OCc1ccccc1)c1ccccc1 | 10.1016/S0960-894X(97)00356-9 | |||
44287086 | 107265 | 0 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 782 | 18 | 7 | 7 | 4.1 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N(C)CC(=O)NC(Cc1ccccc1)C(N)=O | 10.1021/jm00037a005 | |||
CHEMBL290975 | 107265 | 0 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 782 | 18 | 7 | 7 | 4.1 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N(C)CC(=O)NC(Cc1ccccc1)C(N)=O | 10.1021/jm00037a005 | |||
44368382 | 52113 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 511 | 9 | 4 | 4 | 4.5 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1CCCCC1Cl)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
CHEMBL152682 | 52113 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 511 | 9 | 4 | 4 | 4.5 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1CCCCC1Cl)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
10719721 | 214209 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 486 | 7 | 3 | 8 | 3.8 | CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(N(C)C)c2)c1 | 10.1021/jm970373j | |||
CHEMBL9406 | 214209 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 486 | 7 | 3 | 8 | 3.8 | CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(N(C)C)c2)c1 | 10.1021/jm970373j | |||
44368567 | 175514 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 495 | 9 | 4 | 4 | 4.2 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1CCCCC1F)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
CHEMBL437039 | 175514 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 495 | 9 | 4 | 4 | 4.2 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1CCCCC1F)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
CHEMBL2372076 | 216961 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H]1CNC(=O)CCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1016/j.bmc.2007.05.067 | |||||
14208255 | 211447 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 416 | 4 | 2 | 4 | 3.4 | CN(C)c1ccc(C(=O)NC2N=C(c3ccccc3F)c3ccccc3NC2=O)cc1 | 10.1021/jm00047a021 | |||
CHEMBL73745 | 211447 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 416 | 4 | 2 | 4 | 3.4 | CN(C)c1ccc(C(=O)NC2N=C(c3ccccc3F)c3ccccc3NC2=O)cc1 | 10.1021/jm00047a021 | |||
52949124 | 7663 | 4 | None | -2 | 2 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
9055 | 7663 | 4 | None | -2 | 2 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
CHEMBL1269258 | 7663 | 4 | None | -2 | 2 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
DB12694 | 7663 | 4 | None | -2 | 2 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
44286816 | 167553 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 810 | 20 | 7 | 7 | 4.8 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)NCCCC(=O)N(C)C(Cc1ccccc1)C(N)=O | 10.1021/jm00037a005 | |||
CHEMBL41142 | 167553 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 810 | 20 | 7 | 7 | 4.8 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)NCCCC(=O)N(C)C(Cc1ccccc1)C(N)=O | 10.1021/jm00037a005 | |||
44286695 | 167745 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 796 | 19 | 7 | 7 | 4.5 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)NCCC(=O)N(C)C(Cc1ccccc1)C(N)=O | 10.1021/jm00037a005 | |||
CHEMBL41157 | 167745 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 796 | 19 | 7 | 7 | 4.5 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)NCCC(=O)N(C)C(Cc1ccccc1)C(N)=O | 10.1021/jm00037a005 | |||
44592082 | 185922 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 411 | 8 | 4 | 4 | 3.4 | CSCC[C@@H](NC(=O)c1ccccc1NC(=O)c1cc2ccccc2[nH]1)C(=O)O | 10.1016/j.bmc.2009.02.012 | |||
CHEMBL472079 | 185922 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 411 | 8 | 4 | 4 | 3.4 | CSCC[C@@H](NC(=O)c1ccccc1NC(=O)c1cc2ccccc2[nH]1)C(=O)O | 10.1016/j.bmc.2009.02.012 | |||
44300551 | 204174 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 390 | 3 | 2 | 3 | 4.1 | Cc1cccc(NC(=O)NC2N=C(C3CCCC3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(01)80987-2 | |||
CHEMBL56944 | 204174 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 390 | 3 | 2 | 3 | 4.1 | Cc1cccc(NC(=O)NC2N=C(C3CCCC3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(01)80987-2 | |||
46235271 | 80423 | 2 | None | 2 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 649 | 7 | 1 | 6 | 6.7 | Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1021/acs.jmedchem.5b01110 | |||
CHEMBL2017835 | 80423 | 2 | None | 2 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 649 | 7 | 1 | 6 | 6.7 | Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1021/acs.jmedchem.5b01110 | |||
15689737 | 113376 | 0 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 862 | 20 | 9 | 8 | 4.5 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC/N=C(\S)Nc1ccc(Cl)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||
CHEMBL3142701 | 113376 | 0 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 862 | 20 | 9 | 8 | 4.5 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC/N=C(\S)Nc1ccc(Cl)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||
CHEMBL354363 | 218510 | 0 | None | - | 0 | Mouse | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N1CC(=O)N[C@@H](Cc2ccccc2)C1 | 10.1016/S0960-894X(01)80253-5 | |||||
14208255 | 211447 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 416 | 4 | 2 | 4 | 3.4 | CN(C)c1ccc(C(=O)NC2N=C(c3ccccc3F)c3ccccc3NC2=O)cc1 | 10.1021/jm00120a002 | |||
CHEMBL73745 | 211447 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 416 | 4 | 2 | 4 | 3.4 | CN(C)c1ccc(C(=O)NC2N=C(c3ccccc3F)c3ccccc3NC2=O)cc1 | 10.1021/jm00120a002 | |||
443375 | 214385 | 45 | None | - | 5 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00164a020 | |||
CHEMBL9506 | 214385 | 45 | None | - | 5 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00164a020 | |||
9845465 | 125637 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 428 | 5 | 3 | 4 | 3.3 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CCO)C2=O)c1 | 10.1021/jm00078a018 | |||
CHEMBL342201 | 125637 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 428 | 5 | 3 | 4 | 3.3 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CCO)C2=O)c1 | 10.1021/jm00078a018 | |||
44303664 | 107485 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 661 | 16 | 7 | 7 | 0.3 | CCCC1C[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)N(C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)CN)C1 | 10.1016/S0960-894X(01)81005-2 | |||
CHEMBL292493 | 107485 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 661 | 16 | 7 | 7 | 0.3 | CCCC1C[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)N(C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)CN)C1 | 10.1016/S0960-894X(01)81005-2 | |||
CHEMBL3143186 | 217918 | 0 | None | - | 0 | Guinea pig | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | None | None | None | CCC[C@@H]1CCN(C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)[C@@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00105a068 | |||||
73354293 | 113333 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 650 | 12 | 6 | 5 | 4.6 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCP(=O)(O)O)c1ccccc1 | 10.1021/jm00092a007 | |||
CHEMBL314178 | 113333 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 650 | 12 | 6 | 5 | 4.6 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCP(=O)(O)O)c1ccccc1 | 10.1021/jm00092a007 | |||
44312041 | 110474 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 498 | 6 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@H](Cc1ccccc1)C(=O)NC1N=C(c2ccccc2)c2ccccc2NC1=O | 10.1021/jm00120a002 | |||
CHEMBL308769 | 110474 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 498 | 6 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@H](Cc1ccccc1)C(=O)NC1N=C(c2ccccc2)c2ccccc2NC1=O | 10.1021/jm00120a002 | |||
44382243 | 66296 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 632 | 12 | 4 | 4 | 6.1 | O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1)NCc1ccccc1 | 10.1016/S0960-894X(00)80687-3 | |||
CHEMBL171562 | 66296 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 632 | 12 | 4 | 4 | 6.1 | O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1)NCc1ccccc1 | 10.1016/S0960-894X(00)80687-3 | |||
162666759 | 189099 | 0 | None | - | 0 | Guinea pig | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 846 | 23 | 9 | 9 | 2.9 | CC(C)C[C@@H](/C=C/NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)NC(=O)OC(C)(C)C | 10.1021/acs.jmedchem.0c00530 | |||
CHEMBL4784305 | 189099 | 0 | None | - | 0 | Guinea pig | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 846 | 23 | 9 | 9 | 2.9 | CC(C)C[C@@H](/C=C/NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)NC(=O)OC(C)(C)C | 10.1021/acs.jmedchem.0c00530 | |||
15673154 | 92770 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 650 | 12 | 6 | 5 | 4.6 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCP(=O)(O)O)c1ccccc1 | 10.1016/S0960-894X(00)80652-6 | |||
CHEMBL2304155 | 92770 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 650 | 12 | 6 | 5 | 4.6 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCP(=O)(O)O)c1ccccc1 | 10.1016/S0960-894X(00)80652-6 | |||
14208263 | 211494 | 0 | None | - | 0 | Rat | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 425 | 7 | 2 | 3 | 5.0 | CCCCCc1ccc(C(=O)NC2N=C(c3ccccc3)c3ccccc3NC2=O)cc1 | 10.1021/jm00120a002 | |||
CHEMBL74170 | 211494 | 0 | None | - | 0 | Rat | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 425 | 7 | 2 | 3 | 5.0 | CCCCCc1ccc(C(=O)NC2N=C(c3ccccc3)c3ccccc3NC2=O)cc1 | 10.1021/jm00120a002 | |||
14720389 | 171862 | 0 | None | - | 0 | Guinea pig | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 373 | 10 | 3 | 3 | 2.8 | CCCN(CCC)C(=O)[C@H](CCC(=O)O)NC(=O)c1cc2ccccc2[nH]1 | 10.1021/jm00164a020 | |||
CHEMBL422701 | 171862 | 0 | None | - | 0 | Guinea pig | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 373 | 10 | 3 | 3 | 2.8 | CCCN(CCC)C(=O)[C@H](CCC(=O)O)NC(=O)c1cc2ccccc2[nH]1 | 10.1021/jm00164a020 | |||
44381609 | 135890 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 610 | 15 | 6 | 7 | 2.5 | N#C[C@H](N[C@H](CC(=O)NC(Cc1ccccc1)C(N)=O)C(=O)O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1 | 10.1016/S0960-894X(97)00107-8 | |||
CHEMBL367057 | 135890 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 610 | 15 | 6 | 7 | 2.5 | N#C[C@H](N[C@H](CC(=O)NC(Cc1ccccc1)C(N)=O)C(=O)O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1 | 10.1016/S0960-894X(97)00107-8 | |||
44349298 | 23400 | 0 | None | - | 0 | Rat | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 429 | 8 | 3 | 4 | 3.5 | CC(C)c1ccc(C(=O)NC(CCC(=O)O)C(=O)NN2CCC3(CCCC3)CC2)cc1 | 10.1021/jm00079a003 | |||
CHEMBL124155 | 23400 | 0 | None | - | 0 | Rat | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 429 | 8 | 3 | 4 | 3.5 | CC(C)c1ccc(C(=O)NC(CCC(=O)O)C(=O)NN2CCC3(CCCC3)CC2)cc1 | 10.1021/jm00079a003 | |||
44349101 | 23616 | 0 | None | - | 0 | Rat | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 468 | 7 | 3 | 3 | 5.0 | O=C(O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)NC1CCC2(CCCCC2)CC1 | 10.1021/jm00079a003 | |||
CHEMBL124805 | 23616 | 0 | None | - | 0 | Rat | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 468 | 7 | 3 | 3 | 5.0 | O=C(O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)NC1CCC2(CCCCC2)CC1 | 10.1021/jm00079a003 | |||
44592485 | 194605 | 0 | None | - | 0 | Guinea pig | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 379 | 6 | 4 | 3 | 3.3 | CC(C)C(NC(=O)c1ccccc1NC(=O)c1cc2ccccc2[nH]1)C(=O)O | 10.1016/j.bmc.2009.02.012 | |||
CHEMBL496066 | 194605 | 0 | None | - | 0 | Guinea pig | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 379 | 6 | 4 | 3 | 3.3 | CC(C)C(NC(=O)c1ccccc1NC(=O)c1cc2ccccc2[nH]1)C(=O)O | 10.1016/j.bmc.2009.02.012 | |||
42636922 | 185892 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 411 | 8 | 4 | 4 | 3.4 | CSCC[C@H](NC(=O)c1ccccc1NC(=O)c1cc2ccccc2[nH]1)C(=O)O | 10.1016/j.bmc.2009.02.012 | |||
CHEMBL471870 | 185892 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 411 | 8 | 4 | 4 | 3.4 | CSCC[C@H](NC(=O)c1ccccc1NC(=O)c1cc2ccccc2[nH]1)C(=O)O | 10.1016/j.bmc.2009.02.012 | |||
11799462 | 168795 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 497 | 6 | 3 | 6 | 5.3 | CC(C)Oc1cccc(-n2c(NNC(=O)Nc3ccc(C(F)(F)F)cc3)nc3ccccc3c2=O)c1 | 10.1021/jm970373j | |||
CHEMBL415965 | 168795 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 497 | 6 | 3 | 6 | 5.3 | CC(C)Oc1cccc(-n2c(NNC(=O)Nc3ccc(C(F)(F)F)cc3)nc3ccccc3c2=O)c1 | 10.1021/jm970373j | |||
10553146 | 123491 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 491 | 6 | 3 | 3 | 5.7 | CC1CCCCC1NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 | 10.1021/jm970065l | |||
CHEMBL337310 | 123491 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 491 | 6 | 3 | 3 | 5.7 | CC1CCCCC1NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 | 10.1021/jm970065l | |||
9821357 | 24051 | 0 | None | - | 0 | Rat | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 382 | 9 | 3 | 3 | 3.2 | CC(C)(C)CCCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 | 10.1021/jm00079a003 | |||
CHEMBL125703 | 24051 | 0 | None | - | 0 | Rat | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 382 | 9 | 3 | 3 | 3.2 | CC(C)(C)CCCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 | 10.1021/jm00079a003 | |||
45482486 | 205083 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 441 | 7 | 4 | 3 | 4.2 | Cc1ccc2[nH]c(C(=O)Nc3ccccc3C(=O)NC(Cc3ccccc3)C(=O)O)cc2c1 | 10.1016/j.bmc.2009.05.067 | |||
CHEMBL576020 | 205083 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 441 | 7 | 4 | 3 | 4.2 | Cc1ccc2[nH]c(C(=O)Nc3ccccc3C(=O)NC(Cc3ccccc3)C(=O)O)cc2c1 | 10.1016/j.bmc.2009.05.067 | |||
44382371 | 127279 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 436 | 5 | 2 | 4 | 2.8 | COc1cccc(NC(=O)N[C@@H]2CCc3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 | 10.1016/S0960-894X(00)80683-6 | |||
CHEMBL354442 | 127279 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 436 | 5 | 2 | 4 | 2.8 | COc1cccc(NC(=O)N[C@@H]2CCc3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 | 10.1016/S0960-894X(00)80683-6 | |||
14208216 | 109480 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 393 | 3 | 1 | 4 | 3.5 | CN1C(=O)C(NC(=O)c2ccsc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL304768 | 109480 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 393 | 3 | 1 | 4 | 3.5 | CN1C(=O)C(NC(=O)c2ccsc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
44286378 | 174894 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 838 | 21 | 7 | 9 | 3.0 | CN(C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCNC(=O)/C=C/c1cccnc1)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00037a006 | |||
CHEMBL432864 | 174894 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 838 | 21 | 7 | 9 | 3.0 | CN(C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCNC(=O)/C=C/c1cccnc1)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00037a006 | |||
14991586 | 107415 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 838 | 21 | 7 | 9 | 3.0 | CN(C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCNC(=O)/C=C/c1cccnc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
CHEMBL292071 | 107415 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 838 | 21 | 7 | 9 | 3.0 | CN(C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCNC(=O)/C=C/c1cccnc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
5279119 | 211532 | 1 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 423 | 3 | 2 | 3 | 4.5 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccc(Cl)c(Cl)c1 | 10.1021/jm00047a021 | |||
CHEMBL74515 | 211532 | 1 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 423 | 3 | 2 | 3 | 4.5 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccc(Cl)c(Cl)c1 | 10.1021/jm00047a021 | |||
5311201 | 214174 | 35 | None | 26 | 6 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm020424z | |||
CHEMBL9387 | 214174 | 35 | None | 26 | 6 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm020424z | |||
5311201 | 214174 | 35 | None | 26 | 6 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00121a004 | |||
CHEMBL9387 | 214174 | 35 | None | 26 | 6 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00121a004 | |||
5311201 | 214174 | 35 | None | 26 | 6 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm000937a | |||
CHEMBL9387 | 214174 | 35 | None | 26 | 6 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm000937a | |||
5311201 | 214174 | 35 | None | 26 | 6 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(96)00609-9 | |||
CHEMBL9387 | 214174 | 35 | None | 26 | 6 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(96)00609-9 | |||
5311201 | 214174 | 35 | None | 26 | 6 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00164a020 | |||
CHEMBL9387 | 214174 | 35 | None | 26 | 6 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00164a020 | |||
5311201 | 214174 | 35 | None | 26 | 6 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(00)80684-8 | |||
CHEMBL9387 | 214174 | 35 | None | 26 | 6 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(00)80684-8 | |||
CHEMBL172135 | 215629 | 0 | None | - | 0 | Mouse | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N1C[C@H](Cc2ccccc2)NC(=O)[C@H]1CC(=O)O | 10.1016/S0960-894X(01)80253-5 | |||||
44409521 | 146948 | 4 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 351 | 5 | 4 | 3 | 2.6 | CC(NC(=O)c1ccccc1NC(=O)c1cc2ccccc2[nH]1)C(=O)O | 10.1021/jm051050n | |||
CHEMBL380355 | 146948 | 4 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 351 | 5 | 4 | 3 | 2.6 | CC(NC(=O)c1ccccc1NC(=O)c1cc2ccccc2[nH]1)C(=O)O | 10.1021/jm051050n | |||
70697534 | 84622 | 0 | None | - | 0 | Guinea pig | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 367 | 3 | 2 | 3 | 4.4 | O=C1Nc2ccccc2C(c2ccccc2)=NC1C[C@H]1CNc2ccccc21 | 10.1021/jm00390a019 | |||
CHEMBL2092989 | 84622 | 0 | None | - | 0 | Guinea pig | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 367 | 3 | 2 | 3 | 4.4 | O=C1Nc2ccccc2C(c2ccccc2)=NC1C[C@H]1CNc2ccccc21 | 10.1021/jm00390a019 | |||
15167797 | 38430 | 0 | None | - | 0 | Rat | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 403 | 5 | 2 | 4 | 4.4 | O=C(NCC1CNc2ccccc2C(c2ccccc2F)=N1)OCc1ccccc1 | 10.1021/jm00163a069 | |||
CHEMBL140495 | 38430 | 0 | None | - | 0 | Rat | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 403 | 5 | 2 | 4 | 4.4 | O=C(NCC1CNc2ccccc2C(c2ccccc2F)=N1)OCc1ccccc1 | 10.1021/jm00163a069 | |||
44303233 | 107431 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 632 | 12 | 5 | 5 | 5.0 | C[C@](Cc1c[nH]c2ccc(F)cc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1 | 10.1016/S0960-894X(97)00356-9 | |||
CHEMBL292194 | 107431 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 632 | 12 | 5 | 5 | 5.0 | C[C@](Cc1c[nH]c2ccc(F)cc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1 | 10.1016/S0960-894X(97)00356-9 | |||
9985099 | 124056 | 0 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 552 | 5 | 3 | 3 | 6.0 | CC(C)(C)NC(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](c2ccccc2)c2cc(Cl)ccc21 | 10.1021/jm00048a015 | |||
CHEMBL339515 | 124056 | 0 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 552 | 5 | 3 | 3 | 6.0 | CC(C)(C)NC(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](c2ccccc2)c2cc(Cl)ccc21 | 10.1021/jm00048a015 | |||
44592485 | 194605 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 379 | 6 | 4 | 3 | 3.3 | CC(C)C(NC(=O)c1ccccc1NC(=O)c1cc2ccccc2[nH]1)C(=O)O | 10.1016/j.bmc.2009.02.012 | |||
CHEMBL496066 | 194605 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 379 | 6 | 4 | 3 | 3.3 | CC(C)C(NC(=O)c1ccccc1NC(=O)c1cc2ccccc2[nH]1)C(=O)O | 10.1016/j.bmc.2009.02.012 | |||
10255357 | 25290 | 0 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 498 | 5 | 3 | 3 | 5.0 | Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)c3ccccc3N(CC(=O)NC(C)(C)C)C2=O)c1 | 10.1021/jm00048a015 | |||
CHEMBL127397 | 25290 | 0 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 498 | 5 | 3 | 3 | 5.0 | Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)c3ccccc3N(CC(=O)NC(C)(C)C)C2=O)c1 | 10.1021/jm00048a015 | |||
10074366 | 127376 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 491 | 9 | 4 | 4 | 4.5 | C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
CHEMBL3349028 | 127376 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 491 | 9 | 4 | 4 | 4.5 | C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
CHEMBL3545866 | 127376 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 491 | 9 | 4 | 4 | 4.5 | C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
44368567 | 175514 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 495 | 9 | 4 | 4 | 4.2 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1CCCCC1F)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
CHEMBL437039 | 175514 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 495 | 9 | 4 | 4 | 4.2 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1CCCCC1F)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
44349393 | 23606 | 0 | None | - | 0 | Rat | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 422 | 7 | 3 | 3 | 4.3 | O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NC1CCCCCCCCC1 | 10.1021/jm00079a003 | |||
CHEMBL124764 | 23606 | 0 | None | - | 0 | Rat | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 422 | 7 | 3 | 3 | 4.3 | O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NC1CCCCCCCCC1 | 10.1021/jm00079a003 | |||
44381550 | 172012 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 842 | 23 | 11 | 10 | 3.0 | Cc1ccccc1NC(=O)NCCCC[C@@H](CNN[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)NNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C | 10.1016/S0960-894X(00)80680-0 | |||
CHEMBL422919 | 172012 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 842 | 23 | 11 | 10 | 3.0 | Cc1ccccc1NC(=O)NCCCC[C@@H](CNN[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)NNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C | 10.1016/S0960-894X(00)80680-0 | |||
5279119 | 211532 | 1 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 423 | 3 | 2 | 3 | 4.5 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccc(Cl)c(Cl)c1 | 10.1021/jm00120a002 | |||
CHEMBL74515 | 211532 | 1 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 423 | 3 | 2 | 3 | 4.5 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccc(Cl)c(Cl)c1 | 10.1021/jm00120a002 | |||
15104606 | 16229 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 497 | 13 | 2 | 2 | 6.9 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccc2ccccc2c1 | 10.1021/jm00116a002 | |||
CHEMBL111837 | 16229 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 497 | 13 | 2 | 2 | 6.9 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccc2ccccc2c1 | 10.1021/jm00116a002 | |||
44309988 | 109445 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 415 | 4 | 1 | 3 | 4.5 | Cc1ccc(C(=O)NC[C@@H]2CN=C(c3ccc(F)cc3)c3ccc(C)cc3N2C)cc1 | 10.1021/jm00163a069 | |||
CHEMBL304546 | 109445 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 415 | 4 | 1 | 3 | 4.5 | Cc1ccc(C(=O)NC[C@@H]2CN=C(c3ccc(F)cc3)c3ccc(C)cc3N2C)cc1 | 10.1021/jm00163a069 | |||
10698905 | 213651 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 605 | 8 | 1 | 5 | 6.0 | COc1ccc(N(C(=O)CN2C(=O)C(Cc3n[nH]c4cc(F)ccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm970265x | |||
CHEMBL90697 | 213651 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 605 | 8 | 1 | 5 | 6.0 | COc1ccc(N(C(=O)CN2C(=O)C(Cc3n[nH]c4cc(F)ccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm970265x | |||
10077842 | 115864 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 637 | 8 | 2 | 5 | 5.8 | CN(C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C(=O)c3ccccc3)c2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1016/s0960-894x(98)00548-4 | |||
CHEMBL321321 | 115864 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 637 | 8 | 2 | 5 | 5.8 | CN(C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C(=O)c3ccccc3)c2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1016/s0960-894x(98)00548-4 | |||
44458068 | 92537 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 374 | 4 | 2 | 3 | 2.7 | O=C(N[C@H]1C(=O)N(c2ccccc2)C[C@@H]1C(=O)O)c1ccc2ccccc2c1 | 10.1016/S0960-894X(00)80224-3 | |||
CHEMBL22918 | 92537 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 374 | 4 | 2 | 3 | 2.7 | O=C(N[C@H]1C(=O)N(c2ccccc2)C[C@@H]1C(=O)O)c1ccc2ccccc2c1 | 10.1016/S0960-894X(00)80224-3 | |||
10047669 | 85292 | 1 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 418 | 3 | 2 | 3 | 4.3 | CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL2111924 | 85292 | 1 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 418 | 3 | 2 | 3 | 4.3 | CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
14991543 | 113583 | 0 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 839 | 22 | 8 | 8 | 3.5 | Cc1ccc(CCC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 | 10.1021/jm00089a010 | |||
CHEMBL3144544 | 113583 | 0 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 839 | 22 | 8 | 8 | 3.5 | Cc1ccc(CCC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 | 10.1021/jm00089a010 | |||
44334248 | 11452 | 0 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 528 | 8 | 3 | 5 | 4.9 | Cc1cccc(NC(=O)N[C@H](COC(=O)Nc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
CHEMBL103312 | 11452 | 0 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 528 | 8 | 3 | 5 | 4.9 | Cc1cccc(NC(=O)N[C@H](COC(=O)Nc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
20190195 | 37561 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 405 | 4 | 1 | 3 | 4.1 | CN1c2ccccc2C(c2ccccc2F)=NCC1CNC(=O)c1ccccc1F | 10.1021/jm00163a069 | |||
CHEMBL139615 | 37561 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 405 | 4 | 1 | 3 | 4.1 | CN1c2ccccc2C(c2ccccc2F)=NCC1CNC(=O)c1ccccc1F | 10.1021/jm00163a069 | |||
44356619 | 125574 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 415 | 4 | 2 | 5 | 3.1 | COc1ccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cn1 | 10.1021/jm00078a018 | |||
CHEMBL342142 | 125574 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 415 | 4 | 2 | 5 | 3.1 | COc1ccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cn1 | 10.1021/jm00078a018 | |||
11799359 | 35824 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 493 | 6 | 4 | 4 | 4.4 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H]1CCCC[C@H]1O | 10.1021/jm970065l | |||
CHEMBL138084 | 35824 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 493 | 6 | 4 | 4 | 4.4 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H]1CCCC[C@H]1O | 10.1021/jm970065l | |||
54580264 | 68632 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 514 | 5 | 0 | 5 | 6.2 | COc1cccc(-c2ncc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2011.03.069 | |||
CHEMBL1773880 | 68632 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 514 | 5 | 0 | 5 | 6.2 | COc1cccc(-c2ncc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2011.03.069 | |||
21842340 | 50864 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 508 | 6 | 2 | 4 | 5.5 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3(C)CCCC3)C2=O)c1 | 10.1016/0960-894X(95)00556-9 | |||
CHEMBL151483 | 50864 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 508 | 6 | 2 | 4 | 5.5 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3(C)CCCC3)C2=O)c1 | 10.1016/0960-894X(95)00556-9 | |||
45482489 | 205206 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 445 | 7 | 4 | 3 | 4.0 | O=C(Nc1ccccc1C(=O)NC(Cc1ccccc1)C(=O)O)c1cc2ccc(F)cc2[nH]1 | 10.1016/j.bmc.2009.05.067 | |||
CHEMBL577161 | 205206 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 445 | 7 | 4 | 3 | 4.0 | O=C(Nc1ccccc1C(=O)NC(Cc1ccccc1)C(=O)O)c1cc2ccc(F)cc2[nH]1 | 10.1016/j.bmc.2009.05.067 | |||
135703408 | 149614 | 0 | None | - | 0 | Guinea pig | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 511 | 4 | 2 | 6 | 6.0 | O=C1c2ccccc2C(=O)N1Cc1c(O)ccc2c(/C=C/c3ccc(O)cc3)cc3nc4ccccc4n3c12 | 10.1016/j.bmcl.2007.02.071 | |||
CHEMBL389311 | 149614 | 0 | None | - | 0 | Guinea pig | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 511 | 4 | 2 | 6 | 6.0 | O=C1c2ccccc2C(=O)N1Cc1c(O)ccc2c(/C=C/c3ccc(O)cc3)cc3nc4ccccc4n3c12 | 10.1016/j.bmcl.2007.02.071 | |||
9936789 | 213368 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 529 | 7 | 3 | 8 | 5.3 | CC(C)Oc1cccc(-n2c(NNC(=O)Nc3cccc(C(=O)OC(C)(C)C)c3)nc3ccccc3c2=O)c1 | 10.1021/jm970373j | |||
CHEMBL8890 | 213368 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 529 | 7 | 3 | 8 | 5.3 | CC(C)Oc1cccc(-n2c(NNC(=O)Nc3cccc(C(=O)OC(C)(C)C)c3)nc3ccccc3c2=O)c1 | 10.1021/jm970373j | |||
9887120 | 210905 | 4 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00121a004 | |||
CHEMBL70380 | 210905 | 4 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00121a004 | |||
9887120 | 210905 | 4 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm000937a | |||
CHEMBL70380 | 210905 | 4 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm000937a | |||
14208237 | 210992 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 498 | 6 | 2 | 5 | 3.8 | CCOC(=O)CN1C(=O)C(NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL70883 | 210992 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 498 | 6 | 2 | 5 | 3.8 | CCOC(=O)CN1C(=O)C(NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
10079315 | 174647 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 859 | 21 | 9 | 7 | 4.2 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)Nc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00028a015 | |||
CHEMBL431065 | 174647 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 859 | 21 | 9 | 7 | 4.2 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)Nc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00028a015 | |||
CHEMBL156559 | 215584 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | None | None | None | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00028a015 | |||||
14888718 | 84027 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 1041 | 29 | 11 | 14 | -0.1 | CSCC[C@H](NC(=O)[C@H](Cc1ccc(-c2nn[nH]n2)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00107a037 | |||
CHEMBL2079606 | 84027 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 1041 | 29 | 11 | 14 | -0.1 | CSCC[C@H](NC(=O)[C@H](Cc1ccc(-c2nn[nH]n2)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00107a037 | |||
10253366 | 123123 | 13 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 452 | 3 | 2 | 3 | 5.0 | CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2Cl)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL335951 | 123123 | 13 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 452 | 3 | 2 | 3 | 5.0 | CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2Cl)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
10094138 | 175109 | 8 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 429 | 4 | 2 | 5 | 3.6 | CN1C(=O)C(NC(=O)Nc2ccccc2[N+](=O)[O-])N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL434255 | 175109 | 8 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 429 | 4 | 2 | 5 | 3.6 | CN1C(=O)C(NC(=O)Nc2ccccc2[N+](=O)[O-])N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
9887120 | 210905 | 4 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(00)80684-8 | |||
CHEMBL70380 | 210905 | 4 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(00)80684-8 | |||
155540394 | 179715 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 1820 | 69 | 17 | 23 | 2.7 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL4516794 | 179715 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 1820 | 69 | 17 | 23 | 2.7 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
24785179 | 188315 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 502 | 6 | 0 | 5 | 6.1 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2ccccc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
CHEMBL476520 | 188315 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 502 | 6 | 0 | 5 | 6.1 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2ccccc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
14991585 | 107803 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 919 | 21 | 7 | 10 | 4.3 | CC(=O)Oc1ccc2cc(C(=O)NCCCC[C@H](NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc3ccccc3)C(N)=O)ccc2c1 | 10.1021/jm00089a010 | |||
CHEMBL294542 | 107803 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 919 | 21 | 7 | 10 | 4.3 | CC(=O)Oc1ccc2cc(C(=O)NCCCC[C@H](NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc3ccccc3)C(N)=O)ccc2c1 | 10.1021/jm00089a010 | |||
14208292 | 211500 | 1 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 465 | 3 | 1 | 3 | 4.2 | CN1C(=O)C(NC(=O)c2cccc(Br)c2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00047a021 | |||
CHEMBL74228 | 211500 | 1 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 465 | 3 | 1 | 3 | 4.2 | CN1C(=O)C(NC(=O)c2cccc(Br)c2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00047a021 | |||
14208293 | 74524 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 465 | 3 | 1 | 3 | 4.2 | CN1C(=O)[C@@H](NC(=O)c2cccc(Br)c2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL1907851 | 74524 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 465 | 3 | 1 | 3 | 4.2 | CN1C(=O)[C@@H](NC(=O)c2cccc(Br)c2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
15689729 | 113374 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 890 | 20 | 9 | 8 | 4.0 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1Br)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||
CHEMBL3142695 | 113374 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 890 | 20 | 9 | 8 | 4.0 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1Br)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||
44386048 | 68291 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 541 | 9 | 4 | 4 | 5.3 | O=C(O)C[C@@H](Cc1ccccc1)NC(=O)/C(=C/c1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 | 10.1016/S0960-894X(00)80273-5 | |||
CHEMBL177081 | 68291 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 541 | 9 | 4 | 4 | 5.3 | O=C(O)C[C@@H](Cc1ccccc1)NC(=O)/C(=C/c1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 | 10.1016/S0960-894X(00)80273-5 | |||
CHEMBL156559 | 215584 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | None | None | None | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00173a006 | |||||
44381480 | 66229 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 825 | 20 | 7 | 8 | 4.6 | Cc1ccccc1NC(=O)NCCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C | 10.1016/S0960-894X(00)80680-0 | |||
CHEMBL171227 | 66229 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 825 | 20 | 7 | 8 | 4.6 | Cc1ccccc1NC(=O)NCCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C | 10.1016/S0960-894X(00)80680-0 | |||
CHEMBL156559 | 215584 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | None | None | None | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00031a013 | |||||
CHEMBL156559 | 215584 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | None | None | None | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||||
CHEMBL319340 | 217995 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | None | None | None | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1Cl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||||
CHEMBL320868 | 218008 | 0 | None | - | 2 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | None | None | None | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||||
CHEMBL320868 | 218008 | 0 | None | - | 2 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | None | None | None | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm960509y | |||||
CHEMBL319340 | 217995 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | None | None | None | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1Cl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00173a006 | |||||
CHEMBL320868 | 218008 | 0 | None | - | 2 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | None | None | None | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00173a006 | |||||
44381695 | 127616 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 811 | 20 | 8 | 8 | 4.3 | Cc1ccccc1NC(=O)NCCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C | 10.1016/S0960-894X(00)80680-0 | |||
CHEMBL355836 | 127616 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 811 | 20 | 8 | 8 | 4.3 | Cc1ccccc1NC(=O)NCCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C | 10.1016/S0960-894X(00)80680-0 | |||
CHEMBL320868 | 218008 | 0 | None | - | 2 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | None | None | None | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00031a013 | |||||
44398261 | 131164 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 577 | 7 | 4 | 6 | 4.2 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(S)N(Cc3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm0501127 | |||
CHEMBL363916 | 131164 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 577 | 7 | 4 | 6 | 4.2 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(S)N(Cc3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm0501127 | |||
CHEMBL319340 | 217995 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | None | None | None | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1Cl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/S0960-894X(00)80687-3 | |||||
14991584 | 168521 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 877 | 20 | 8 | 9 | 4.1 | CN(C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCNC(=O)c1ccc2cc(O)ccc2c1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
CHEMBL413768 | 168521 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 877 | 20 | 8 | 9 | 4.1 | CN(C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCNC(=O)c1ccc2cc(O)ccc2c1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
71452818 | 86489 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 541 | 9 | 4 | 4 | 5.3 | O=C(O)C[C@@H](Cc1ccccc1)NC(=O)C(=Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 | 10.1016/S0960-894X(00)80273-5 | |||
CHEMBL2115543 | 86489 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 541 | 9 | 4 | 4 | 5.3 | O=C(O)C[C@@H](Cc1ccccc1)NC(=O)C(=Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 | 10.1016/S0960-894X(00)80273-5 | |||
CHEMBL317477 | 217982 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | None | None | None | COC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00028a015 | |||||
10074366 | 127376 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 491 | 9 | 4 | 4 | 4.5 | C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
CHEMBL3349028 | 127376 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 491 | 9 | 4 | 4 | 4.5 | C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
CHEMBL3545866 | 127376 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 491 | 9 | 4 | 4 | 4.5 | C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
11146119 | 85210 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 559 | 6 | 3 | 5 | 4.4 | Cc1cccc(N2C(=O)C[C@H]3[C@H](NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)OC(C)(C)C)CCCN3C2=O)c1 | 10.1021/jm010813d | |||
CHEMBL2111550 | 85210 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 559 | 6 | 3 | 5 | 4.4 | Cc1cccc(N2C(=O)C[C@H]3[C@H](NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)OC(C)(C)C)CCCN3C2=O)c1 | 10.1021/jm010813d | |||
44382038 | 127238 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 420 | 4 | 2 | 3 | 3.1 | Cc1cccc(NC(=O)N[C@@H]2CCc3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 | 10.1016/S0960-894X(00)80683-6 | |||
CHEMBL354040 | 127238 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 420 | 4 | 2 | 3 | 3.1 | Cc1cccc(NC(=O)N[C@@H]2CCc3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 | 10.1016/S0960-894X(00)80683-6 | |||
903 | 9798 | 9 | None | - | 1 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1016/S0960-894X(00)80273-5 | |||
9850711 | 9798 | 9 | None | - | 1 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1016/S0960-894X(00)80273-5 | |||
CHEMBL138534 | 9798 | 9 | None | - | 1 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1016/S0960-894X(00)80273-5 | |||
CHEMBL2111312 | 9798 | 9 | None | - | 1 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1016/S0960-894X(00)80273-5 | |||
178143 | 23624 | 2 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 440 | 14 | 2 | 3 | 5.0 | CCCCCN(CCCCC)C(=O)C(CCC(=O)O)NC(=O)c1ccc2ccccc2c1 | 10.1021/jm00079a003 | |||
CHEMBL124832 | 23624 | 2 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 440 | 14 | 2 | 3 | 5.0 | CCCCCN(CCCCC)C(=O)C(CCC(=O)O)NC(=O)c1ccc2ccccc2c1 | 10.1021/jm00079a003 | |||
44381915 | 65830 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 454 | 15 | 2 | 3 | 5.4 | CCCCCN(CCCCC)C(=O)[C@@H](CCCC(=O)O)NC(=O)c1ccc2ccccc2c1 | 10.1016/S0960-894X(00)80681-2 | |||
CHEMBL169466 | 65830 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 454 | 15 | 2 | 3 | 5.4 | CCCCCN(CCCCC)C(=O)[C@@H](CCCC(=O)O)NC(=O)c1ccc2ccccc2c1 | 10.1016/S0960-894X(00)80681-2 | |||
CHEMBL2079548 | 215970 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1ccc(C(=O)O)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00107a037 | |||||
24785430 | 189063 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 530 | 6 | 0 | 5 | 6.8 | Cc1ccc(-c2nc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)cn2-c2cccc(OC(C)C)c2)cc1 | 10.1016/j.bmcl.2008.06.057 | |||
CHEMBL478397 | 189063 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 530 | 6 | 0 | 5 | 6.8 | Cc1ccc(-c2nc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)cn2-c2cccc(OC(C)C)c2)cc1 | 10.1016/j.bmcl.2008.06.057 | |||
14991581 | 109214 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 855 | 22 | 8 | 9 | 3.2 | CN(C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCNC(=O)CCc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
CHEMBL303994 | 109214 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 855 | 22 | 8 | 9 | 3.2 | CN(C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCNC(=O)CCc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
90663985 | 113592 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 853 | 22 | 8 | 9 | 3.3 | COc1ccc(/C=C\C(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 | 10.1021/jm00089a010 | |||
CHEMBL3144554 | 113592 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 853 | 22 | 8 | 9 | 3.3 | COc1ccc(/C=C\C(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 | 10.1021/jm00089a010 | |||
44349268 | 23558 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 399 | 9 | 3 | 4 | 3.1 | CC(C)(C)CCCNC(=O)C(CCC(=O)O)NC(=O)c1cnc2ccccc2c1 | 10.1021/jm00079a003 | |||
CHEMBL124509 | 23558 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 399 | 9 | 3 | 4 | 3.1 | CC(C)(C)CCCNC(=O)C(CCC(=O)O)NC(=O)c1cnc2ccccc2c1 | 10.1021/jm00079a003 | |||
44381482 | 65847 | 0 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 827 | 22 | 10 | 9 | 3.5 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@H](CNN[C@@H](Cc1ccccc1)C(N)=O)CC(=O)O | 10.1016/S0960-894X(00)80680-0 | |||
CHEMBL169567 | 65847 | 0 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 827 | 22 | 10 | 9 | 3.5 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@H](CNN[C@@H](Cc1ccccc1)C(N)=O)CC(=O)O | 10.1016/S0960-894X(00)80680-0 | |||
13822916 | 196505 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 421 | 3 | 1 | 4 | 5.3 | Cc1nnc2n1-c1ccccc1C(c1ccccc1F)=N[C@@H]2Cc1c[nH]c2ccccc12 | 10.1021/jm00396a028 | |||
CHEMBL51569 | 196505 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 421 | 3 | 1 | 4 | 5.3 | Cc1nnc2n1-c1ccccc1C(c1ccccc1F)=N[C@@H]2Cc1c[nH]c2ccccc12 | 10.1021/jm00396a028 | |||
89913710 | 147599 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 285 | 2 | 1 | 2 | 2.9 | CC(C)N1C(=O)C=C(Cl)C1(O)c1ccc(Cl)cc1 | 10.1039/C6MD00052E | |||
CHEMBL3819054 | 147599 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 285 | 2 | 1 | 2 | 2.9 | CC(C)N1C(=O)C=C(Cl)C1(O)c1ccc(Cl)cc1 | 10.1039/C6MD00052E | |||
73349790 | 112953 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 725 | 14 | 5 | 6 | 5.4 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCNS(=O)(=O)c1ccccc1)c1ccccc1 | 10.1021/jm00092a007 | |||
CHEMBL313756 | 112953 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 725 | 14 | 5 | 6 | 5.4 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCNS(=O)(=O)c1ccccc1)c1ccccc1 | 10.1021/jm00092a007 | |||
14208205 | 210997 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 425 | 3 | 2 | 5 | 3.3 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ncc2ccccc2n1 | 10.1021/jm00120a002 | |||
CHEMBL70896 | 210997 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 425 | 3 | 2 | 5 | 3.3 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ncc2ccccc2n1 | 10.1021/jm00120a002 | |||
14208238 | 210911 | 1 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 394 | 5 | 3 | 3 | 4.1 | O=C1Nc2ccccc2C(c2ccccc2)=NC1NCCc1c[nH]c2ccccc12 | 10.1021/jm00120a002 | |||
CHEMBL70405 | 210911 | 1 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 394 | 5 | 3 | 3 | 4.1 | O=C1Nc2ccccc2C(c2ccccc2)=NC1NCCc1c[nH]c2ccccc12 | 10.1021/jm00120a002 | |||
10648445 | 65687 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 481 | 6 | 4 | 7 | 2.8 | CN1C(=O)[C@H](NC(=O)Nc2cccc(CNc3nn[nH]n3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm9506736 | |||
CHEMBL168903 | 65687 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 481 | 6 | 4 | 7 | 2.8 | CN1C(=O)[C@H](NC(=O)Nc2cccc(CNc3nn[nH]n3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm9506736 | |||
10695559 | 65811 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 467 | 5 | 4 | 7 | 2.9 | CN1C(=O)[C@H](NC(=O)Nc2cccc(Nc3nn[nH]n3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm9506736 | |||
CHEMBL169362 | 65811 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 467 | 5 | 4 | 7 | 2.9 | CN1C(=O)[C@H](NC(=O)Nc2cccc(Nc3nn[nH]n3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm9506736 | |||
10576729 | 66004 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 481 | 5 | 4 | 7 | 3.2 | Cc1ccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc1Nc1nn[nH]n1 | 10.1021/jm9506736 | |||
CHEMBL170275 | 66004 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 481 | 5 | 4 | 7 | 3.2 | Cc1ccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc1Nc1nn[nH]n1 | 10.1021/jm9506736 | |||
10814625 | 90242 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 481 | 5 | 3 | 7 | 2.9 | CN1C(=O)[C@H](NC(=O)Nc2cccc(N(C)c3nn[nH]n3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm9506736 | |||
CHEMBL22003 | 90242 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 481 | 5 | 3 | 7 | 2.9 | CN1C(=O)[C@H](NC(=O)Nc2cccc(N(C)c3nn[nH]n3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm9506736 | |||
10815094 | 127177 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 495 | 5 | 3 | 7 | 3.2 | Cc1ccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc1N(C)c1nn[nH]n1 | 10.1021/jm9506736 | |||
CHEMBL353509 | 127177 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 495 | 5 | 3 | 7 | 3.2 | Cc1ccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc1N(C)c1nn[nH]n1 | 10.1021/jm9506736 | |||
44356620 | 35434 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 400 | 3 | 3 | 5 | 2.6 | CN1C(=O)C(NC(=O)Nc2ccc(N)nc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL137748 | 35434 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 400 | 3 | 3 | 5 | 2.6 | CN1C(=O)C(NC(=O)Nc2ccc(N)nc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
10765241 | 110757 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 433 | 5 | 3 | 4 | 3.8 | CCCN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C([C@H]2CCCCN2)c2ccccc21 | 10.1021/jm9608523 | |||
CHEMBL309299 | 110757 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 433 | 5 | 3 | 4 | 3.8 | CCCN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C([C@H]2CCCCN2)c2ccccc21 | 10.1021/jm9608523 | |||
10717652 | 112934 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 433 | 5 | 3 | 4 | 3.8 | CCCN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C([C@@H]2CCCCN2)c2ccccc21 | 10.1021/jm9608523 | |||
CHEMBL313653 | 112934 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 433 | 5 | 3 | 4 | 3.8 | CCCN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C([C@@H]2CCCCN2)c2ccccc21 | 10.1021/jm9608523 | |||
CHEMBL44345 | 220701 | 0 | None | - | 0 | Rat | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(N)=O | 10.1021/jm00378a012 | |||||
15167802 | 74486 | 0 | None | - | 0 | Guinea pig | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 436 | 5 | 1 | 3 | 5.0 | N#CCCN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00390a019 | |||
CHEMBL1907720 | 74486 | 0 | None | - | 0 | Guinea pig | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 436 | 5 | 1 | 3 | 5.0 | N#CCCN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00390a019 | |||
15614820 | 74498 | 0 | None | - | 0 | Guinea pig | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 437 | 5 | 1 | 2 | 5.5 | O=C1[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc2N1CC1CC1 | 10.1021/jm00390a019 | |||
CHEMBL1907737 | 74498 | 0 | None | - | 0 | Guinea pig | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 437 | 5 | 1 | 2 | 5.5 | O=C1[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc2N1CC1CC1 | 10.1021/jm00390a019 | |||
15614818 | 74502 | 0 | None | - | 0 | Guinea pig | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 411 | 4 | 1 | 2 | 5.1 | CCN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00390a019 | |||
CHEMBL1907742 | 74502 | 0 | None | - | 0 | Guinea pig | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 411 | 4 | 1 | 2 | 5.1 | CCN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00390a019 | |||
44370505 | 58054 | 0 | None | - | 0 | Guinea pig | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 543 | 10 | 2 | 4 | 6.3 | O=C(CC[C@H](NC(=O)c1cc2ccccc2[nH]1)C(=O)N(C1CCCCC1)C1CCCCC1)OCc1ccccc1 | 10.1021/jm00164a020 | |||
CHEMBL158078 | 58054 | 0 | None | - | 0 | Guinea pig | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 543 | 10 | 2 | 4 | 6.3 | O=C(CC[C@H](NC(=O)c1cc2ccccc2[nH]1)C(=O)N(C1CCCCC1)C1CCCCC1)OCc1ccccc1 | 10.1021/jm00164a020 | |||
24039375 | 16659 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 540 | 8 | 2 | 6 | 4.9 | CCN(CC)c1cccc(NC(=O)N[C@@H]2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1021/jm960669+ | |||
CHEMBL114277 | 16659 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 540 | 8 | 2 | 6 | 4.9 | CCN(CC)c1cccc(NC(=O)N[C@@H]2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1021/jm960669+ | |||
10575687 | 214019 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 453 | 4 | 3 | 5 | 5.2 | Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(Cl)c2Cl)c1 | 10.1021/jm970373j | |||
CHEMBL9287 | 214019 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 453 | 4 | 3 | 5 | 5.2 | Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(Cl)c2Cl)c1 | 10.1021/jm970373j | |||
45482483 | 204976 | 0 | None | - | 0 | Rat | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 445 | 7 | 4 | 3 | 4.0 | O=C(Nc1ccccc1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)c1cc2cc(F)ccc2[nH]1 | 10.1016/j.bmc.2009.05.067 | |||
CHEMBL575160 | 204976 | 0 | None | - | 0 | Rat | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 445 | 7 | 4 | 3 | 4.0 | O=C(Nc1ccccc1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)c1cc2cc(F)ccc2[nH]1 | 10.1016/j.bmc.2009.05.067 | |||
14208205 | 210997 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 425 | 3 | 2 | 5 | 3.3 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ncc2ccccc2n1 | 10.1021/jm00047a021 | |||
CHEMBL70896 | 210997 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 425 | 3 | 2 | 5 | 3.3 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ncc2ccccc2n1 | 10.1021/jm00047a021 | |||
10649606 | 56390 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 519 | 6 | 3 | 4 | 4.5 | O=C(CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)Nc1ccccc1 | 10.1016/j.bmcl.2015.03.051 | |||
CHEMBL156605 | 56390 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 519 | 6 | 3 | 4 | 4.5 | O=C(CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)Nc1ccccc1 | 10.1016/j.bmcl.2015.03.051 | |||
9805700 | 125933 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 492 | 6 | 3 | 4 | 4.9 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NN1CCCCCC1 | 10.1021/jm970065l | |||
CHEMBL342932 | 125933 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 492 | 6 | 3 | 4 | 4.9 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NN1CCCCCC1 | 10.1021/jm970065l | |||
44381319 | 127503 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 495 | 11 | 4 | 5 | 3.6 | N#C[C@H](N[C@@H](Cc1ccccc1)C(N)=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1 | 10.1016/S0960-894X(97)00107-8 | |||
CHEMBL354817 | 127503 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 495 | 11 | 4 | 5 | 3.6 | N#C[C@H](N[C@@H](Cc1ccccc1)C(N)=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1 | 10.1016/S0960-894X(97)00107-8 | |||
10556460 | 213518 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 677 | 10 | 0 | 6 | 7.4 | COc1ccc(N(C(=O)CN2C(=O)C(Cc3nn(Cc4ccccc4)c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm960249k | |||
CHEMBL89953 | 213518 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 677 | 10 | 0 | 6 | 7.4 | COc1ccc(N(C(=O)CN2C(=O)C(Cc3nn(Cc4ccccc4)c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm960249k | |||
10556460 | 213518 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 677 | 10 | 0 | 6 | 7.4 | COc1ccc(N(C(=O)CN2C(=O)C(Cc3nn(Cc4ccccc4)c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm970265x | |||
CHEMBL89953 | 213518 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 677 | 10 | 0 | 6 | 7.4 | COc1ccc(N(C(=O)CN2C(=O)C(Cc3nn(Cc4ccccc4)c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm970265x | |||
10344702 | 35403 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 471 | 7 | 2 | 5 | 3.6 | COc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CCN(C)C)C2=O)c1 | 10.1021/jm00078a018 | |||
CHEMBL137714 | 35403 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 471 | 7 | 2 | 5 | 3.6 | COc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CCN(C)C)C2=O)c1 | 10.1021/jm00078a018 | |||
10837729 | 113222 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 461 | 5 | 3 | 4 | 4.5 | CCCN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C([C@H]2CC(C)(C)CCN2)c2ccccc21 | 10.1021/jm9608523 | |||
CHEMBL313983 | 113222 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 461 | 5 | 3 | 4 | 4.5 | CCCN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C([C@H]2CC(C)(C)CCN2)c2ccccc21 | 10.1021/jm9608523 | |||
14519983 | 126754 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 441 | 14 | 2 | 4 | 4.4 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1ccc2ncccc2c1 | 10.1021/jm00124a003 | |||
CHEMBL349857 | 126754 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 441 | 14 | 2 | 4 | 4.4 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1ccc2ncccc2c1 | 10.1021/jm00124a003 | |||
44306360 | 164654 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 816 | 18 | 9 | 7 | 3.4 | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NC(Cc1ccc(NC(=O)Nc2ccccc2C)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccc(C)cc1)C(N)=O | 10.1021/jm00001a027 | |||
CHEMBL408395 | 164654 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 816 | 18 | 9 | 7 | 3.4 | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NC(Cc1ccc(NC(=O)Nc2ccccc2C)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccc(C)cc1)C(N)=O | 10.1021/jm00001a027 | |||
CHEMBL1172249 | 215361 | 0 | None | -5 | 4 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H]1Cc2ccccc2CN1C(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/j.bmcl.2010.05.078 | |||||
52949124 | 7663 | 4 | None | -2 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1016/j.bmcl.2010.08.115 | |||
9055 | 7663 | 4 | None | -2 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1016/j.bmcl.2010.08.115 | |||
CHEMBL1269258 | 7663 | 4 | None | -2 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1016/j.bmcl.2010.08.115 | |||
DB12694 | 7663 | 4 | None | -2 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1016/j.bmcl.2010.08.115 | |||
44301034 | 108364 | 0 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 556 | 6 | 3 | 5 | 4.8 | COC(=O)c1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)c3ccc(C)cc3N(CC(=O)NC(C)(C)C)C2=O)c1 | 10.1016/0960-894X(95)00327-P | |||
CHEMBL298627 | 108364 | 0 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 556 | 6 | 3 | 5 | 4.8 | COC(=O)c1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)c3ccc(C)cc3N(CC(=O)NC(C)(C)C)C2=O)c1 | 10.1016/0960-894X(95)00327-P | |||
44336585 | 117459 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 641 | 7 | 2 | 6 | 5.7 | CN(C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C3(C(F)(F)F)N=N3)c2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1016/s0960-894x(98)00548-4 | |||
CHEMBL325987 | 117459 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 641 | 7 | 2 | 6 | 5.7 | CN(C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C3(C(F)(F)F)N=N3)c2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1016/s0960-894x(98)00548-4 | |||
10252890 | 32395 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 444 | 5 | 2 | 5 | 3.7 | COc1cc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc(OC)c1 | 10.1021/jm00078a018 | |||
CHEMBL135167 | 32395 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 444 | 5 | 2 | 5 | 3.7 | COc1cc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc(OC)c1 | 10.1021/jm00078a018 | |||
44356868 | 32748 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 412 | 3 | 2 | 3 | 4.3 | Cc1ccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc1C | 10.1021/jm00078a018 | |||
CHEMBL135433 | 32748 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 412 | 3 | 2 | 3 | 4.3 | Cc1ccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc1C | 10.1021/jm00078a018 | |||
10071645 | 34767 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 435 | 3 | 2 | 4 | 4.2 | CN1C(=O)C(NC(=O)Nc2ccc3ncccc3c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL137238 | 34767 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 435 | 3 | 2 | 4 | 4.2 | CN1C(=O)C(NC(=O)Nc2ccc3ncccc3c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
14991534 | 113569 | 0 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 825 | 22 | 8 | 8 | 3.2 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
CHEMBL3144531 | 113569 | 0 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 825 | 22 | 8 | 8 | 3.2 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
14991566 | 175012 | 0 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 831 | 22 | 8 | 8 | 3.9 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCC1CCCCC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
CHEMBL433636 | 175012 | 0 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 831 | 22 | 8 | 8 | 3.9 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCC1CCCCC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
44280741 | 163341 | 0 | None | - | 1 | Mouse | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 759 | 15 | 4 | 8 | 5.8 | CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00249-1 | |||
CHEMBL406844 | 163341 | 0 | None | - | 1 | Mouse | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 759 | 15 | 4 | 8 | 5.8 | CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00249-1 | |||
44312020 | 109984 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 398 | 5 | 3 | 4 | 2.5 | N[C@H](Cc1ccccc1)C(=O)NC1N=C(c2ccccc2)c2ccccc2NC1=O | 10.1021/jm00120a002 | |||
CHEMBL308404 | 109984 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 398 | 5 | 3 | 4 | 2.5 | N[C@H](Cc1ccccc1)C(=O)NC1N=C(c2ccccc2)c2ccccc2NC1=O | 10.1021/jm00120a002 | |||
71452652 | 85279 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 628 | 13 | 5 | 5 | 5.2 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCC[C@H](NC(=O)CCC(=O)O)c1ccccc1 | 10.1021/jm00105a062 | |||
CHEMBL2111884 | 85279 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 628 | 13 | 5 | 5 | 5.2 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCC[C@H](NC(=O)CCC(=O)O)c1ccccc1 | 10.1021/jm00105a062 | |||
14802539 | 83327 | 1 | None | - | 1 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1 | 10.1016/S0960-894X(01)80769-1 | |||
CHEMBL2062144 | 83327 | 1 | None | - | 1 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1 | 10.1016/S0960-894X(01)80769-1 | |||
44382561 | 175085 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 662 | 13 | 5 | 5 | 5.8 | O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1)NCCc1ccc(O)cc1 | 10.1016/S0960-894X(00)80687-3 | |||
CHEMBL434113 | 175085 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 662 | 13 | 5 | 5 | 5.8 | O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1)NCCc1ccc(O)cc1 | 10.1016/S0960-894X(00)80687-3 | |||
14802538 | 103464 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCC(=O)O)c1ccccc1 | 10.1016/S0960-894X(00)80685-X | |||
CHEMBL263969 | 103464 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCC(=O)O)c1ccccc1 | 10.1016/S0960-894X(00)80685-X | |||
19756868 | 35190 | 2 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 409 | 3 | 2 | 4 | 3.5 | CN1C(=O)C(NC(=O)Nc2cccc(C#N)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL137520 | 35190 | 2 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 409 | 3 | 2 | 4 | 3.5 | CN1C(=O)C(NC(=O)Nc2cccc(C#N)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
10475990 | 122776 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1ccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc1 | 10.1021/jm00078a018 | |||
CHEMBL33554 | 122776 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1ccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc1 | 10.1021/jm00078a018 | |||
44379627 | 64906 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 520 | 7 | 2 | 5 | 4.9 | CC(C)Oc1cccc(-n2c(CNC(=O)NCc3ccc(Br)cc3)nc3ccccc3c2=O)c1 | 10.1016/S0960-894X(97)00108-X | |||
CHEMBL167758 | 64906 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 520 | 7 | 2 | 5 | 4.9 | CC(C)Oc1cccc(-n2c(CNC(=O)NCc3ccc(Br)cc3)nc3ccccc3c2=O)c1 | 10.1016/S0960-894X(97)00108-X | |||
CHEMBL432671 | 174874 | 0 | None | - | 1 | Mouse | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 784 | 15 | 7 | 12 | 3.1 | CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCNC(=O)CC(=O)NCCSCc3csc(C=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00249-1 | |||
14802538 | 103464 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCC(=O)O)c1ccccc1 | 10.1021/jm970065l | |||
CHEMBL263969 | 103464 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCC(=O)O)c1ccccc1 | 10.1021/jm970065l | |||
53465843 | 76185 | 0 | None | - | 2 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 441 | 8 | 4 | 3 | 4.2 | O=C(Nc1ccccc1C(=O)N[C@@H](CCc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 | 10.1021/jm200438b | |||
CHEMBL1933103 | 76185 | 0 | None | - | 2 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 441 | 8 | 4 | 3 | 4.2 | O=C(Nc1ccccc1C(=O)N[C@@H](CCc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 | 10.1021/jm200438b | |||
11178152 | 205126 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 439 | 7 | 3 | 4 | 3.9 | O=C(Nc1ccccc1C(=O)NC(Cc1ccccc1)C(=O)O)c1cnc2ccccc2c1 | 10.1016/j.bmc.2009.05.067 | |||
CHEMBL576380 | 205126 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 439 | 7 | 3 | 4 | 3.9 | O=C(Nc1ccccc1C(=O)NC(Cc1ccccc1)C(=O)O)c1cnc2ccccc2c1 | 10.1016/j.bmc.2009.05.067 | |||
44349152 | 25334 | 0 | None | - | 0 | Rat | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 354 | 10 | 3 | 3 | 2.6 | CCCCCNC(=O)C(CCC(=O)O)NC(=O)c1ccc(Cl)cc1 | 10.1021/jm00079a003 | |||
CHEMBL127604 | 25334 | 0 | None | - | 0 | Rat | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 354 | 10 | 3 | 3 | 2.6 | CCCCCNC(=O)C(CCC(=O)O)NC(=O)c1ccc(Cl)cc1 | 10.1021/jm00079a003 | |||
44381892 | 19048 | 0 | None | - | 0 | Rat | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 510 | 9 | 2 | 4 | 3.7 | CN(C)CCNC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1016/S0960-894X(00)80681-2 | |||
CHEMBL1184772 | 19048 | 0 | None | - | 0 | Rat | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 510 | 9 | 2 | 4 | 3.7 | CN(C)CCNC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1016/S0960-894X(00)80681-2 | |||
CHEMBL368133 | 19048 | 0 | None | - | 0 | Rat | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 510 | 9 | 2 | 4 | 3.7 | CN(C)CCNC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1016/S0960-894X(00)80681-2 | |||
CHEMBL385727 | 219140 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N1CSC(C)(C)[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00100a033 | |||||
10049168 | 204655 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 445 | 7 | 4 | 3 | 4.0 | O=C(Nc1ccccc1C(=O)NC(Cc1ccccc1)C(=O)O)c1cc2cc(F)ccc2[nH]1 | 10.1016/j.bmc.2009.05.067 | |||
CHEMBL572648 | 204655 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 445 | 7 | 4 | 3 | 4.0 | O=C(Nc1ccccc1C(=O)NC(Cc1ccccc1)C(=O)O)c1cc2cc(F)ccc2[nH]1 | 10.1016/j.bmc.2009.05.067 | |||
44592009 | 185683 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 397 | 6 | 3 | 2 | 4.8 | CC(Cc1ccccc1)NC(=O)c1ccccc1NC(=O)c1cc2ccccc2[nH]1 | 10.1016/j.bmc.2009.02.012 | |||
CHEMBL469974 | 185683 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 397 | 6 | 3 | 2 | 4.8 | CC(Cc1ccccc1)NC(=O)c1ccccc1NC(=O)c1cc2ccccc2[nH]1 | 10.1016/j.bmc.2009.02.012 | |||
CHEMBL206974 | 215961 | 0 | None | -72 | 5 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm050921q | |||||
10649606 | 56390 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 519 | 6 | 3 | 4 | 4.5 | O=C(CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)Nc1ccccc1 | 10.1016/j.bmcl.2015.03.051 | |||
CHEMBL156605 | 56390 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 519 | 6 | 3 | 4 | 4.5 | O=C(CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)Nc1ccccc1 | 10.1016/j.bmcl.2015.03.051 | |||
10744012 | 104154 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 501 | 8 | 3 | 8 | 4.5 | CCOC(=O)c1ccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(OC(C)C)c2)cc1 | 10.1021/jm970373j | |||
CHEMBL269662 | 104154 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 501 | 8 | 3 | 8 | 4.5 | CCOC(=O)c1ccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(OC(C)C)c2)cc1 | 10.1021/jm970373j | |||
CHEMBL407057 | 219414 | 0 | None | -1513 | 4 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O | 10.1021/jm050921q | |||||
44365304 | 171531 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 444 | 8 | 2 | 3 | 4.3 | CC(C)N(C(=O)CN(C(=O)CNC(=O)Nc1ccccc1)c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(97)00062-0 | |||
CHEMBL421778 | 171531 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 444 | 8 | 2 | 3 | 4.3 | CC(C)N(C(=O)CN(C(=O)CNC(=O)Nc1ccccc1)c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(97)00062-0 | |||
53465781 | 76181 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 413 | 6 | 4 | 3 | 4.0 | O=C(Nc1ccccc1C(=O)NC(C(=O)O)c1ccccc1)c1cc2ccccc2[nH]1 | 10.1021/jm200438b | |||
CHEMBL1933099 | 76181 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 413 | 6 | 4 | 3 | 4.0 | O=C(Nc1ccccc1C(=O)NC(C(=O)O)c1ccccc1)c1cc2ccccc2[nH]1 | 10.1021/jm200438b | |||
10030027 | 24718 | 0 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 532 | 5 | 3 | 3 | 5.6 | Cc1ccc2c(c1)[C@@H](c1ccccc1)C[C@@H](NC(=O)Nc1cccc(Cl)c1)C(=O)N2CC(=O)NC(C)(C)C | 10.1021/jm00048a015 | |||
CHEMBL126002 | 24718 | 0 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 532 | 5 | 3 | 3 | 5.6 | Cc1ccc2c(c1)[C@@H](c1ccccc1)C[C@@H](NC(=O)Nc1cccc(Cl)c1)C(=O)N2CC(=O)NC(C)(C)C | 10.1021/jm00048a015 | |||
CHEMBL2372072 | 216958 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CN)NC(=O)[C@H](CCSC)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](CCC(=O)O)N(CCN(CCC(=O)O)CCC(=O)O)CCN(CCC(=O)O)CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/j.bmc.2007.05.067 | |||||
14208247 | 211430 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 465 | 5 | 2 | 4 | 3.5 | O=C(O)CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL73621 | 211430 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 465 | 5 | 2 | 4 | 3.5 | O=C(O)CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
10323690 | 107274 | 0 | None | - | 2 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 499 | 8 | 3 | 3 | 5.4 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccc1 | 10.1021/jm00086a017 | |||
CHEMBL2114401 | 107274 | 0 | None | - | 2 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 499 | 8 | 3 | 3 | 5.4 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccc1 | 10.1021/jm00086a017 | |||
CHEMBL291033 | 107274 | 0 | None | - | 2 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 499 | 8 | 3 | 3 | 5.4 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccc1 | 10.1021/jm00086a017 | |||
10674587 | 85616 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 570 | 8 | 3 | 6 | 4.5 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)[C@@H](C#N)N[C@@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm991078x | |||
CHEMBL2112825 | 85616 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 570 | 8 | 3 | 6 | 4.5 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)[C@@H](C#N)N[C@@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm991078x | |||
44301016 | 164755 | 0 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 673 | 7 | 4 | 6 | 4.5 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)NS(=O)(=O)C(F)(F)F)c1)C[C@@H]2c1ccccc1 | 10.1016/0960-894X(95)00327-P | |||
CHEMBL408490 | 164755 | 0 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 673 | 7 | 4 | 6 | 4.5 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)NS(=O)(=O)C(F)(F)F)c1)C[C@@H]2c1ccccc1 | 10.1016/0960-894X(95)00327-P | |||
14519979 | 16302 | 0 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 440 | 14 | 2 | 3 | 5.0 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1cccc2ccccc12 | 10.1021/jm00124a003 | |||
CHEMBL112215 | 16302 | 0 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 440 | 14 | 2 | 3 | 5.0 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1cccc2ccccc12 | 10.1021/jm00124a003 | |||
10099144 | 121319 | 0 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 552 | 5 | 3 | 3 | 6.0 | CC(C)(C)NC(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](c2ccccc2)c2ccc(Cl)cc21 | 10.1021/jm00048a015 | |||
CHEMBL333671 | 121319 | 0 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 552 | 5 | 3 | 3 | 6.0 | CC(C)(C)NC(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](c2ccccc2)c2ccc(Cl)cc21 | 10.1021/jm00048a015 | |||
14519979 | 16302 | 0 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 440 | 14 | 2 | 3 | 5.0 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1cccc2ccccc12 | 10.1021/jm00116a002 | |||
CHEMBL112215 | 16302 | 0 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 440 | 14 | 2 | 3 | 5.0 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1cccc2ccccc12 | 10.1021/jm00116a002 | |||
21467078 | 11197 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 448 | 4 | 2 | 5 | 2.9 | CCCN1C(=O)C(NC(=O)Nc2cccc(C)c2)N=C(N2CCN(C)CC2)c2ccccc21 | 10.1016/0960-894X(95)00530-0 | |||
CHEMBL101528 | 11197 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 448 | 4 | 2 | 5 | 2.9 | CCCN1C(=O)C(NC(=O)Nc2cccc(C)c2)N=C(N2CCN(C)CC2)c2ccccc21 | 10.1016/0960-894X(95)00530-0 | |||
44210428 | 65888 | 0 | None | - | 0 | Rat | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 485 | 4 | 2 | 4 | 3.1 | CN1CCN(C(=O)CN2C(=O)C(NC(=O)Nc3cccc4ccccc34)CCc3ccccc32)CC1 | 10.1016/S0960-894X(00)80683-6 | |||
CHEMBL169794 | 65888 | 0 | None | - | 0 | Rat | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 485 | 4 | 2 | 4 | 3.1 | CN1CCN(C(=O)CN2C(=O)C(NC(=O)Nc3cccc4ccccc34)CCc3ccccc32)CC1 | 10.1016/S0960-894X(00)80683-6 | |||
14519977 | 126727 | 0 | None | - | 0 | Guinea pig | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 429 | 14 | 3 | 3 | 4.3 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1c[nH]c2ccccc12 | 10.1021/jm00124a003 | |||
CHEMBL349640 | 126727 | 0 | None | - | 0 | Guinea pig | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 429 | 14 | 3 | 3 | 4.3 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1c[nH]c2ccccc12 | 10.1021/jm00124a003 | |||
10601173 | 37967 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 491 | 6 | 3 | 3 | 5.9 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1CCCCCC1 | 10.1021/jm970065l | |||
CHEMBL140073 | 37967 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 491 | 6 | 3 | 3 | 5.9 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1CCCCCC1 | 10.1021/jm970065l | |||
10372508 | 105337 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 694 | 13 | 6 | 6 | 4.9 | Cc1ccccc1NC(=O)NCCCC[C@@H](CC(=O)O)NC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@H]2C[C@H](NC(=O)OCc3ccccc3)C(=O)N12 | 10.1016/s0960-894x(01)00630-8 | |||
CHEMBL276613 | 105337 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 694 | 13 | 6 | 6 | 4.9 | Cc1ccccc1NC(=O)NCCCC[C@@H](CC(=O)O)NC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@H]2C[C@H](NC(=O)OCc3ccccc3)C(=O)N12 | 10.1016/s0960-894x(01)00630-8 | |||
44409521 | 146948 | 4 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 351 | 5 | 4 | 3 | 2.6 | CC(NC(=O)c1ccccc1NC(=O)c1cc2ccccc2[nH]1)C(=O)O | 10.1016/j.bmc.2009.02.012 | |||
CHEMBL380355 | 146948 | 4 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 351 | 5 | 4 | 3 | 2.6 | CC(NC(=O)c1ccccc1NC(=O)c1cc2ccccc2[nH]1)C(=O)O | 10.1016/j.bmc.2009.02.012 | |||
44349383 | 23539 | 0 | None | - | 0 | Rat | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 480 | 9 | 3 | 3 | 4.7 | O=C(O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)NCCC12CC3CC(CC(C3)C1)C2 | 10.1021/jm00079a003 | |||
CHEMBL124396 | 23539 | 0 | None | - | 0 | Rat | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 480 | 9 | 3 | 3 | 4.7 | O=C(O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)NCCC12CC3CC(CC(C3)C1)C2 | 10.1021/jm00079a003 | |||
54587149 | 68634 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 514 | 5 | 0 | 5 | 6.2 | COc1cccc(-c2cnc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2011.03.069 | |||
CHEMBL1773883 | 68634 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 514 | 5 | 0 | 5 | 6.2 | COc1cccc(-c2cnc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2011.03.069 | |||
90663982 | 113589 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 855 | 21 | 10 | 10 | 2.7 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(O)c(O)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
CHEMBL3144551 | 113589 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 855 | 21 | 10 | 10 | 2.7 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(O)c(O)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
14991572 | 169959 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 848 | 20 | 8 | 9 | 3.4 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1cnc2ccccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
CHEMBL418123 | 169959 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 848 | 20 | 8 | 9 | 3.4 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1cnc2ccccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
10649606 | 56390 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 519 | 6 | 3 | 4 | 4.5 | O=C(CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)Nc1ccccc1 | 10.1016/j.bmcl.2015.03.051 | |||
CHEMBL156605 | 56390 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 519 | 6 | 3 | 4 | 4.5 | O=C(CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)Nc1ccccc1 | 10.1016/j.bmcl.2015.03.051 | |||
57393204 | 74463 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 431 | 5 | 1 | 4 | 3.3 | COc1cccc(CC(=O)N[C@H]2N=C(c3ccccc3F)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00120a002 | |||
CHEMBL1907666 | 74463 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 431 | 5 | 1 | 4 | 3.3 | COc1cccc(CC(=O)N[C@H]2N=C(c3ccccc3F)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00120a002 | |||
44280029 | 103216 | 0 | None | - | 1 | Mouse | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 740 | 15 | 6 | 9 | 3.5 | CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCC(=O)NCCSCc3csc(N=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00248-X | |||
CHEMBL262125 | 103216 | 0 | None | - | 1 | Mouse | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 740 | 15 | 6 | 9 | 3.5 | CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCC(=O)NCCSCc3csc(N=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00248-X | |||
44279810 | 110621 | 0 | None | - | 1 | Mouse | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 757 | 16 | 4 | 7 | 5.7 | CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00248-X | |||
CHEMBL30917 | 110621 | 0 | None | - | 1 | Mouse | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 757 | 16 | 4 | 7 | 5.7 | CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00248-X | |||
44209154 | 65868 | 1 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 315 | 4 | 2 | 2 | 4.2 | O=C(CCc1ccccc1)Nc1cc2c3ccccc3nc-2c[nH]1 | 10.1016/S0960-894X(00)80682-4 | |||
CHEMBL169675 | 65868 | 1 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 315 | 4 | 2 | 2 | 4.2 | O=C(CCc1ccccc1)Nc1cc2c3ccccc3nc-2c[nH]1 | 10.1016/S0960-894X(00)80682-4 | |||
15167795 | 80853 | 0 | None | - | 0 | Guinea pig | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 344 | 2 | 0 | 3 | 4.6 | CN1C(=O)/C(=C\c2ccsc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00390a019 | |||
CHEMBL20223 | 80853 | 0 | None | - | 0 | Guinea pig | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 344 | 2 | 0 | 3 | 4.6 | CN1C(=O)/C(=C\c2ccsc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00390a019 | |||
44336539 | 11916 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 563 | 7 | 2 | 5 | 4.6 | COc1ccc(N(C)C(=O)CN2C(=O)C(NC(=O)Nc3ccccc3)C(=O)N(c3ccccc3)c3ccccc32)cc1 | 10.1016/j.bmcl.2015.03.051 | |||
CHEMBL105775 | 11916 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 563 | 7 | 2 | 5 | 4.6 | COc1ccc(N(C)C(=O)CN2C(=O)C(NC(=O)Nc3ccccc3)C(=O)N(c3ccccc3)c3ccccc32)cc1 | 10.1016/j.bmcl.2015.03.051 | |||
44349082 | 24547 | 0 | None | - | 0 | Rat | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 446 | 9 | 3 | 3 | 4.0 | O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NCCC12CC3CC(CC(C3)C1)C2 | 10.1021/jm00079a003 | |||
CHEMBL125874 | 24547 | 0 | None | - | 0 | Rat | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 446 | 9 | 3 | 3 | 4.0 | O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NCCC12CC3CC(CC(C3)C1)C2 | 10.1021/jm00079a003 | |||
44359614 | 38642 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 491 | 8 | 3 | 4 | 5.5 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)CNC1CCCCC1 | 10.1021/jm970065l | |||
CHEMBL140701 | 38642 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 491 | 8 | 3 | 4 | 5.5 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)CNC1CCCCC1 | 10.1021/jm970065l | |||
44382327 | 66131 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 436 | 5 | 2 | 4 | 2.8 | COc1cccc(NC(=O)N[C@H]2CCc3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 | 10.1016/S0960-894X(00)80683-6 | |||
CHEMBL170777 | 66131 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 436 | 5 | 2 | 4 | 2.8 | COc1cccc(NC(=O)N[C@H]2CCc3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 | 10.1016/S0960-894X(00)80683-6 | |||
44327450 | 174980 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 558 | 10 | 3 | 5 | 4.6 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccn1)CC(=O)O | 10.1016/S0960-894X(01)80769-1 | |||
CHEMBL433384 | 174980 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 558 | 10 | 3 | 5 | 4.6 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccn1)CC(=O)O | 10.1016/S0960-894X(01)80769-1 | |||
14208250 | 174829 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 403 | 3 | 1 | 3 | 3.9 | CN1C(=O)C(NC(=O)c2ccccc2Cl)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00047a021 | |||
CHEMBL432334 | 174829 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 403 | 3 | 1 | 3 | 3.9 | CN1C(=O)C(NC(=O)c2ccccc2Cl)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00047a021 | |||
11327818 | 204883 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 428 | 7 | 4 | 4 | 3.2 | O=C(Nc1ccccc1C(=O)NC(Cc1ccccc1)C(=O)O)c1nc2ccccc2[nH]1 | 10.1016/j.bmc.2009.05.067 | |||
CHEMBL574488 | 204883 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 428 | 7 | 4 | 4 | 3.2 | O=C(Nc1ccccc1C(=O)NC(Cc1ccccc1)C(=O)O)c1nc2ccccc2[nH]1 | 10.1016/j.bmc.2009.05.067 | |||
44300890 | 108667 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 580 | 7 | 4 | 6 | 4.3 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(-c3nn[nH]n3)c1)C[C@@H]2Cc1ccccc1 | 10.1016/0960-894X(95)00327-P | |||
CHEMBL300776 | 108667 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 580 | 7 | 4 | 6 | 4.3 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(-c3nn[nH]n3)c1)C[C@@H]2Cc1ccccc1 | 10.1016/0960-894X(95)00327-P | |||
15689732 | 113392 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 870 | 21 | 9 | 10 | 3.0 | COC(=O)c1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||
CHEMBL3142906 | 113392 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 870 | 21 | 9 | 10 | 3.0 | COC(=O)c1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||
15689732 | 113392 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 870 | 21 | 9 | 10 | 3.0 | COC(=O)c1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm960509y | |||
CHEMBL3142906 | 113392 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 870 | 21 | 9 | 10 | 3.0 | COC(=O)c1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm960509y | |||
44349572 | 121837 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 533 | 5 | 2 | 4 | 6.0 | Cc1ccc2c(c1)N(CC(=O)OC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2c1ccccc1 | 10.1021/jm00048a015 | |||
CHEMBL334305 | 121837 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 533 | 5 | 2 | 4 | 6.0 | Cc1ccc2c(c1)N(CC(=O)OC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2c1ccccc1 | 10.1021/jm00048a015 | |||
10455303 | 121998 | 8 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 429 | 4 | 2 | 5 | 3.6 | CN1C(=O)C(NC(=O)Nc2cccc([N+](=O)[O-])c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL334592 | 121998 | 8 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 429 | 4 | 2 | 5 | 3.6 | CN1C(=O)C(NC(=O)Nc2cccc([N+](=O)[O-])c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
10604135 | 85614 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 637 | 8 | 3 | 5 | 5.1 | O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@H]12)OC1C2CC3CC(C2)CC1C3 | 10.1021/jm991078x | |||
CHEMBL2112823 | 85614 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 637 | 8 | 3 | 5 | 5.1 | O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@H]12)OC1C2CC3CC(C2)CC1C3 | 10.1021/jm991078x | |||
70693814 | 80418 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 621 | 7 | 1 | 6 | 6.1 | O=C1C(Cc2c[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc2N1CC(=O)N1CCCCC1Cc1ccncc1 | 10.1016/j.bmcl.2012.02.049 | |||
CHEMBL2017830 | 80418 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 621 | 7 | 1 | 6 | 6.1 | O=C1C(Cc2c[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc2N1CC(=O)N1CCCCC1Cc1ccncc1 | 10.1016/j.bmcl.2012.02.049 | |||
44311939 | 211274 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 530 | 6 | 2 | 5 | 4.2 | CN1C(=O)C(NC(=O)[C@H](Cc2ccccc2)NC(=O)OC(C)(C)C)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL72526 | 211274 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 530 | 6 | 2 | 5 | 4.2 | CN1C(=O)C(NC(=O)[C@H](Cc2ccccc2)NC(=O)OC(C)(C)C)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
44396765 | 74149 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 594 | 8 | 2 | 5 | 5.4 | O=C(OC1C2CC3CC(C2)CC1C3)[C@H](Cc1c[nH]c2ccccc12)N[C@@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)CC12 | 10.1021/jm0498755 | |||
CHEMBL188667 | 74149 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 594 | 8 | 2 | 5 | 5.4 | O=C(OC1C2CC3CC(C2)CC1C3)[C@H](Cc1c[nH]c2ccccc12)N[C@@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)CC12 | 10.1021/jm0498755 | |||
10074702 | 34387 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 500 | 8 | 2 | 6 | 4.0 | CCOC(=O)CCN1C(=O)C(NC(=O)Nc2cccc(OC)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL136966 | 34387 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 500 | 8 | 2 | 6 | 4.0 | CCOC(=O)CCN1C(=O)C(NC(=O)Nc2cccc(OC)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
44279809 | 105743 | 0 | None | - | 1 | Mouse | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 785 | 18 | 4 | 7 | 6.4 | CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00248-X | |||
CHEMBL279778 | 105743 | 0 | None | - | 1 | Mouse | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 785 | 18 | 4 | 7 | 6.4 | CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00248-X | |||
14208317 | 74464 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 421 | 3 | 1 | 3 | 4.0 | CN1C(=O)[C@H](NC(=O)c2ccccc2Cl)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL1907667 | 74464 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 421 | 3 | 1 | 3 | 4.0 | CN1C(=O)[C@H](NC(=O)c2ccccc2Cl)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
14208250 | 174829 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 403 | 3 | 1 | 3 | 3.9 | CN1C(=O)C(NC(=O)c2ccccc2Cl)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL432334 | 174829 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 403 | 3 | 1 | 3 | 3.9 | CN1C(=O)C(NC(=O)c2ccccc2Cl)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
9865694 | 210955 | 0 | None | - | 0 | Mouse | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 399 | 3 | 2 | 2 | 5.2 | O=C1Nc2ccc(Cl)cc2C(c2ccccc2)=N[C@@H]1Cc1c[nH]c2ccccc12 | 10.1021/jm00120a002 | |||
CHEMBL70728 | 210955 | 0 | None | - | 0 | Mouse | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 399 | 3 | 2 | 2 | 5.2 | O=C1Nc2ccc(Cl)cc2C(c2ccccc2)=N[C@@H]1Cc1c[nH]c2ccccc12 | 10.1021/jm00120a002 | |||
44280122 | 106275 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 640 | 10 | 3 | 4 | 5.7 | CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)[C@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm950372w | |||
CHEMBL283276 | 106275 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 640 | 10 | 3 | 4 | 5.7 | CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)[C@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm950372w | |||
44370497 | 171972 | 0 | None | - | 0 | Guinea pig | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 453 | 8 | 3 | 3 | 4.6 | O=C(O)CC[C@H](NC(=O)c1cc2ccccc2[nH]1)C(=O)N(C1CCCCC1)C1CCCCC1 | 10.1021/jm00164a020 | |||
CHEMBL422873 | 171972 | 0 | None | - | 0 | Guinea pig | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 453 | 8 | 3 | 3 | 4.6 | O=C(O)CC[C@H](NC(=O)c1cc2ccccc2[nH]1)C(=O)N(C1CCCCC1)C1CCCCC1 | 10.1021/jm00164a020 | |||
44334325 | 174753 | 0 | None | - | 0 | Guinea pig | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 485 | 9 | 2 | 3 | 5.2 | Cc1cccc(NC(=O)N[C@H](COCc2ccccc2)C(=O)N2CCC(Cc3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
CHEMBL431812 | 174753 | 0 | None | - | 0 | Guinea pig | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 485 | 9 | 2 | 3 | 5.2 | Cc1cccc(NC(=O)N[C@H](COCc2ccccc2)C(=O)N2CCC(Cc3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
1043 | 8363 | 14 | None | - | 29 | Mouse | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 10.1016/S0960-894X(00)80644-7 | |||
149 | 8363 | 14 | None | - | 29 | Mouse | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 10.1016/S0960-894X(00)80644-7 | |||
8223 | 8363 | 14 | None | - | 29 | Mouse | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 10.1016/S0960-894X(00)80644-7 | |||
CHEMBL442 | 8363 | 14 | None | - | 29 | Mouse | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 10.1016/S0960-894X(00)80644-7 | |||
DB00696 | 8363 | 14 | None | - | 29 | Mouse | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 10.1016/S0960-894X(00)80644-7 | |||
15167794 | 105675 | 0 | None | - | 0 | Guinea pig | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 344 | 2 | 0 | 3 | 4.6 | CN1C(=O)/C(=C/c2ccsc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00390a019 | |||
CHEMBL279237 | 105675 | 0 | None | - | 0 | Guinea pig | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 344 | 2 | 0 | 3 | 4.6 | CN1C(=O)/C(=C/c2ccsc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00390a019 | |||
10649303 | 214235 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 507 | 6 | 3 | 6 | 5.1 | CC(C)Oc1cccc(-n2c(NNC(=O)Nc3ccc(Br)cc3)nc3ccccc3c2=O)c1 | 10.1021/jm970373j | |||
CHEMBL9422 | 214235 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 507 | 6 | 3 | 6 | 5.1 | CC(C)Oc1cccc(-n2c(NNC(=O)Nc3ccc(Br)cc3)nc3ccccc3c2=O)c1 | 10.1021/jm970373j | |||
10625474 | 35999 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 508 | 8 | 3 | 5 | 4.2 | COC[C@H]1CCCN1NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 | 10.1021/jm970065l | |||
CHEMBL138233 | 35999 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 508 | 8 | 3 | 5 | 4.2 | COC[C@H]1CCCN1NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 | 10.1021/jm970065l | |||
44381610 | 127267 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 610 | 15 | 6 | 7 | 2.5 | N#C[C@@H](N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1 | 10.1016/S0960-894X(97)00107-8 | |||
CHEMBL354359 | 127267 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 610 | 15 | 6 | 7 | 2.5 | N#C[C@@H](N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1 | 10.1016/S0960-894X(97)00107-8 | |||
10791546 | 213862 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 501 | 8 | 3 | 8 | 4.5 | CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(OC(C)C)c2)c1 | 10.1021/jm970373j | |||
CHEMBL9188 | 213862 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 501 | 8 | 3 | 8 | 4.5 | CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(OC(C)C)c2)c1 | 10.1021/jm970373j | |||
46235271 | 80423 | 2 | None | 2 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 649 | 7 | 1 | 6 | 6.7 | Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1021/acs.jmedchem.5b01110 | |||
CHEMBL2017835 | 80423 | 2 | None | 2 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 649 | 7 | 1 | 6 | 6.7 | Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1021/acs.jmedchem.5b01110 | |||
54581260 | 68633 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 513 | 5 | 0 | 4 | 6.8 | COc1cccc(-c2ccc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2011.03.069 | |||
CHEMBL1773882 | 68633 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 513 | 5 | 0 | 4 | 6.8 | COc1cccc(-c2ccc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2011.03.069 | |||
54586147 | 68636 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 515 | 5 | 0 | 6 | 5.6 | COc1cccc(-c2cnc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2011.03.069 | |||
CHEMBL1773885 | 68636 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 515 | 5 | 0 | 6 | 5.6 | COc1cccc(-c2cnc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2011.03.069 | |||
54580267 | 68646 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 535 | 5 | 0 | 6 | 6.0 | COc1ccc(-c2cnc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccccc2Cl)cc1 | 10.1016/j.bmcl.2011.03.069 | |||
CHEMBL1773895 | 68646 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 535 | 5 | 0 | 6 | 6.0 | COc1ccc(-c2cnc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccccc2Cl)cc1 | 10.1016/j.bmcl.2011.03.069 | |||
14888738 | 105130 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 984 | 28 | 10 | 13 | 0.8 | CSCC[C@H](NC(=O)CCc1ccc(-c2nn[nH]n2)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00107a037 | |||
CHEMBL275167 | 105130 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 984 | 28 | 10 | 13 | 0.8 | CSCC[C@H](NC(=O)CCc1ccc(-c2nn[nH]n2)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00107a037 | |||
44578611 | 196437 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 520 | 6 | 0 | 5 | 6.2 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2cccc(F)c2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
CHEMBL515160 | 196437 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 520 | 6 | 0 | 5 | 6.2 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2cccc(F)c2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
19766169 | 172345 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 443 | 4 | 2 | 4 | 4.2 | CC(C)(C)OC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)CCc2ccccc21 | 10.1016/S0960-894X(00)80683-6 | |||
CHEMBL424211 | 172345 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 443 | 4 | 2 | 4 | 4.2 | CC(C)(C)OC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)CCc2ccccc21 | 10.1016/S0960-894X(00)80683-6 | |||
44336509 | 114130 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 667 | 9 | 2 | 6 | 5.8 | COc1ccc(N(C)C(=O)CN2C(=O)C(NC(=O)Nc3cccc(C(=O)c4ccccc4)c3)C(=O)N(c3ccccc3)c3ccccc32)cc1 | 10.1016/s0960-894x(98)00548-4 | |||
CHEMBL317668 | 114130 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 667 | 9 | 2 | 6 | 5.8 | COc1ccc(N(C)C(=O)CN2C(=O)C(NC(=O)Nc3cccc(C(=O)c4ccccc4)c3)C(=O)N(c3ccccc3)c3ccccc32)cc1 | 10.1016/s0960-894x(98)00548-4 | |||
9980735 | 185225 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 441 | 7 | 3 | 4 | 3.9 | Cn1c(C(=O)Nc2ccccc2C(=O)NC(Cc2ccccc2)C(=O)O)cc2ccccc21 | 10.1016/j.bmc.2009.05.067 | |||
CHEMBL466135 | 185225 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 441 | 7 | 3 | 4 | 3.9 | Cn1c(C(=O)Nc2ccccc2C(=O)NC(Cc2ccccc2)C(=O)O)cc2ccccc21 | 10.1016/j.bmc.2009.05.067 | |||
15104626 | 117394 | 0 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 448 | 7 | 3 | 3 | 4.4 | O=C(N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccccc1)c1cnc2ccccc2c1 | 10.1021/jm00116a002 | |||
CHEMBL325662 | 117394 | 0 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 448 | 7 | 3 | 3 | 4.4 | O=C(N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccccc1)c1cnc2ccccc2c1 | 10.1021/jm00116a002 | |||
3081191 | 16320 | 14 | None | - | 0 | Guinea pig | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 441 | 14 | 2 | 4 | 4.4 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1cnc2ccccc2c1 | 10.1021/jm00124a003 | |||
CHEMBL112307 | 16320 | 14 | None | - | 0 | Guinea pig | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 441 | 14 | 2 | 4 | 4.4 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1cnc2ccccc2c1 | 10.1021/jm00124a003 | |||
44272229 | 105521 | 0 | None | - | 1 | Mouse | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 635 | 15 | 6 | 6 | 3.5 | CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 | 10.1016/S0960-894X(00)80644-7 | |||
CHEMBL278032 | 105521 | 0 | None | - | 1 | Mouse | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 635 | 15 | 6 | 6 | 3.5 | CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 | 10.1016/S0960-894X(00)80644-7 | |||
44272229 | 105521 | 0 | None | - | 1 | Mouse | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 635 | 15 | 6 | 6 | 3.5 | CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 | 10.1016/S0960-894X(01)80253-5 | |||
CHEMBL278032 | 105521 | 0 | None | - | 1 | Mouse | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 635 | 15 | 6 | 6 | 3.5 | CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 | 10.1016/S0960-894X(01)80253-5 | |||
19754254 | 127128 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 321 | 2 | 2 | 2 | 4.6 | O=C(Nc1cc2c3ccccc3nc-2c[nH]1)c1ccc(Cl)cc1 | 10.1016/S0960-894X(00)80682-4 | |||
CHEMBL353088 | 127128 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 321 | 2 | 2 | 2 | 4.6 | O=C(Nc1cc2c3ccccc3nc-2c[nH]1)c1ccc(Cl)cc1 | 10.1016/S0960-894X(00)80682-4 | |||
44349102 | 175108 | 0 | None | - | 0 | Rat | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 434 | 7 | 3 | 3 | 4.3 | O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NC1CCC2(CCCCC2)CC1 | 10.1021/jm00079a003 | |||
CHEMBL434250 | 175108 | 0 | None | - | 0 | Rat | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 434 | 7 | 3 | 3 | 4.3 | O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NC1CCC2(CCCCC2)CC1 | 10.1021/jm00079a003 | |||
10817407 | 113908 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 601 | 7 | 1 | 6 | 5.6 | CC(C)N(C(=O)CN1C(=O)C(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc21)c1ccc2c(c1)OCO2 | 10.1021/jm970265x | |||
CHEMBL316106 | 113908 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 601 | 7 | 1 | 6 | 5.6 | CC(C)N(C(=O)CN1C(=O)C(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc21)c1ccc2c(c1)OCO2 | 10.1021/jm970265x | |||
10767360 | 212624 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 489 | 5 | 2 | 4 | 5.2 | CCCN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C([C@H]2CCC(C)(C)CCN2C)c2ccccc21 | 10.1021/jm9608523 | |||
CHEMBL83591 | 212624 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 489 | 5 | 2 | 4 | 5.2 | CCCN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C([C@H]2CCC(C)(C)CCN2C)c2ccccc21 | 10.1021/jm9608523 | |||
44408590 | 168505 | 0 | None | - | 2 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 1134 | 30 | 12 | 15 | 2.6 | CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)C(=O)O | 10.1021/jm050851n | |||
CHEMBL413644 | 168505 | 0 | None | - | 2 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 1134 | 30 | 12 | 15 | 2.6 | CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)C(=O)O | 10.1021/jm050851n | |||
44418923 | 168564 | 0 | None | - | 2 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 1132 | 28 | 13 | 13 | 1.7 | CCCC[C@H](NC(=O)[C@@H](Cc1cc2ccccc2[nH]1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm061268p | |||
CHEMBL414087 | 168564 | 0 | None | - | 2 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 1132 | 28 | 13 | 13 | 1.7 | CCCC[C@H](NC(=O)[C@@H](Cc1cc2ccccc2[nH]1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm061268p | |||
45482480 | 204654 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 472 | 8 | 4 | 5 | 3.8 | O=C(Nc1ccccc1C(=O)NC(Cc1ccccc1)C(=O)O)c1cc2cc([N+](=O)[O-])ccc2[nH]1 | 10.1016/j.bmc.2009.05.067 | |||
CHEMBL572647 | 204654 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 472 | 8 | 4 | 5 | 3.8 | O=C(Nc1ccccc1C(=O)NC(Cc1ccccc1)C(=O)O)c1cc2cc([N+](=O)[O-])ccc2[nH]1 | 10.1016/j.bmc.2009.05.067 | |||
45482477 | 204858 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 445 | 7 | 4 | 3 | 4.0 | O=C(Nc1ccccc1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)c1cc2cccc(F)c2[nH]1 | 10.1016/j.bmc.2009.05.067 | |||
CHEMBL574292 | 204858 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 445 | 7 | 4 | 3 | 4.0 | O=C(Nc1ccccc1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)c1cc2cccc(F)c2[nH]1 | 10.1016/j.bmc.2009.05.067 | |||
44211352 | 20757 | 0 | None | - | 0 | Rat | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 522 | 6 | 1 | 4 | 3.8 | CN1CCN(C(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCC3)CC2)CC1 | 10.1016/S0960-894X(00)80681-2 | |||
CHEMBL1196916 | 20757 | 0 | None | - | 0 | Rat | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 522 | 6 | 1 | 4 | 3.8 | CN1CCN(C(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCC3)CC2)CC1 | 10.1016/S0960-894X(00)80681-2 | |||
CHEMBL558614 | 20757 | 0 | None | - | 0 | Rat | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 522 | 6 | 1 | 4 | 3.8 | CN1CCN(C(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCC3)CC2)CC1 | 10.1016/S0960-894X(00)80681-2 | |||
10671800 | 213522 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 463 | 6 | 3 | 6 | 5.0 | CC(C)Oc1cccc(-n2c(NNC(=O)Nc3ccc(Cl)cc3)nc3ccccc3c2=O)c1 | 10.1021/jm970373j | |||
CHEMBL8997 | 213522 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 463 | 6 | 3 | 6 | 5.0 | CC(C)Oc1cccc(-n2c(NNC(=O)Nc3ccc(Cl)cc3)nc3ccccc3c2=O)c1 | 10.1021/jm970373j | |||
70691750 | 80421 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 621 | 7 | 1 | 6 | 6.1 | O=C1[C@@H](Cc2n[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc2N1CC(=O)N1CCCCC1Cc1ccccc1 | 10.1016/j.bmcl.2012.02.049 | |||
CHEMBL2017833 | 80421 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 621 | 7 | 1 | 6 | 6.1 | O=C1[C@@H](Cc2n[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc2N1CC(=O)N1CCCCC1Cc1ccccc1 | 10.1016/j.bmcl.2012.02.049 | |||
44336539 | 11916 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 563 | 7 | 2 | 5 | 4.6 | COc1ccc(N(C)C(=O)CN2C(=O)C(NC(=O)Nc3ccccc3)C(=O)N(c3ccccc3)c3ccccc32)cc1 | 10.1016/j.bmcl.2015.03.051 | |||
CHEMBL105775 | 11916 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 563 | 7 | 2 | 5 | 4.6 | COc1ccc(N(C)C(=O)CN2C(=O)C(NC(=O)Nc3ccccc3)C(=O)N(c3ccccc3)c3ccccc32)cc1 | 10.1016/j.bmcl.2015.03.051 | |||
10555363 | 103262 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 588 | 9 | 1 | 4 | 6.6 | CCC1(CC(=O)Nc2ccccc2)C(=O)N(CC(=O)N(c2ccccc2)C(C)C)c2ccccc2N(c2ccccc2)C1=O | 10.1021/jm960205b | |||
CHEMBL262444 | 103262 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 588 | 9 | 1 | 4 | 6.6 | CCC1(CC(=O)Nc2ccccc2)C(=O)N(CC(=O)N(c2ccccc2)C(C)C)c2ccccc2N(c2ccccc2)C1=O | 10.1021/jm960205b | |||
155553502 | 180954 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 1822 | 72 | 19 | 22 | 3.0 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OP(=O)(O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL4547294 | 180954 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 1822 | 72 | 19 | 22 | 3.0 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OP(=O)(O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
44303511 | 166539 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 750 | 18 | 4 | 10 | 5.7 | CCCC[C@@H](C(=O)N[C@@H](CC(=O)OCc1ccccc1)[C@@H](Cc1ccccc1)C(N)=O)n1nnnc1[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C | 10.1016/S0960-894X(01)81005-2 | |||
CHEMBL410511 | 166539 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 750 | 18 | 4 | 10 | 5.7 | CCCC[C@@H](C(=O)N[C@@H](CC(=O)OCc1ccccc1)[C@@H](Cc1ccccc1)C(N)=O)n1nnnc1[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C | 10.1016/S0960-894X(01)81005-2 | |||
70695922 | 80370 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 558 | 6 | 1 | 5 | 5.9 | CCC1CCCCN1C(=O)CN1C(=O)C(Cc2c[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc21 | 10.1016/j.bmcl.2012.02.049 | |||
CHEMBL2017691 | 80370 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 558 | 6 | 1 | 5 | 5.9 | CCC1CCCCN1C(=O)CN1C(=O)C(Cc2c[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc21 | 10.1016/j.bmcl.2012.02.049 | |||
44458101 | 174925 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 363 | 4 | 3 | 3 | 2.0 | O=C(N[C@H]1C(=O)N(c2ccccc2)C[C@@H]1C(=O)O)c1cc2ccccc2[nH]1 | 10.1016/S0960-894X(00)80224-3 | |||
CHEMBL433032 | 174925 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 363 | 4 | 3 | 3 | 2.0 | O=C(N[C@H]1C(=O)N(c2ccccc2)C[C@@H]1C(=O)O)c1cc2ccccc2[nH]1 | 10.1016/S0960-894X(00)80224-3 | |||
72947518 | 147575 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 277 | 2 | 1 | 2 | 2.7 | O=C1C=C(Cl)C(O)(c2ccccc2)N1C1CCCC1 | 10.1039/C6MD00052E | |||
CHEMBL3818781 | 147575 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 277 | 2 | 1 | 2 | 2.7 | O=C1C=C(Cl)C(O)(c2ccccc2)N1C1CCCC1 | 10.1039/C6MD00052E | |||
44348764 | 175411 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 980 | 28 | 11 | 11 | 1.4 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCCNC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00099a005 | |||
CHEMBL436199 | 175411 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 980 | 28 | 11 | 11 | 1.4 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCCNC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00099a005 | |||
CHEMBL435339 | 220444 | 0 | None | - | 0 | Mouse | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N1C[C@@H](Cc2ccccc2)NC(=O)[C@@H]1CC(=O)O | 10.1016/S0960-894X(01)80253-5 | |||||
89913059 | 147501 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 327 | 6 | 1 | 2 | 4.0 | CCCCCCN1C(=O)C=C(Cl)C1(O)c1ccc(Cl)cc1 | 10.1039/C6MD00052E | |||
CHEMBL3817870 | 147501 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 327 | 6 | 1 | 2 | 4.0 | CCCCCCN1C(=O)C=C(Cl)C1(O)c1ccc(Cl)cc1 | 10.1039/C6MD00052E | |||
14208261 | 110464 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 397 | 5 | 2 | 3 | 4.2 | CCCc1ccc(C(=O)NC2N=C(c3ccccc3)c3ccccc3NC2=O)cc1 | 10.1021/jm00120a002 | |||
CHEMBL308756 | 110464 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 397 | 5 | 2 | 3 | 4.2 | CCCc1ccc(C(=O)NC2N=C(c3ccccc3)c3ccccc3NC2=O)cc1 | 10.1021/jm00120a002 | |||
44280371 | 109805 | 0 | None | - | 1 | Mouse | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 815 | 19 | 4 | 8 | 6.6 | Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCCCCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
CHEMBL30701 | 109805 | 0 | None | - | 1 | Mouse | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 815 | 19 | 4 | 8 | 6.6 | Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCCCCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
44281020 | 123422 | 0 | None | - | 1 | Mouse | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 773 | 16 | 4 | 8 | 6.2 | CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00249-1 | |||
CHEMBL33698 | 123422 | 0 | None | - | 1 | Mouse | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 773 | 16 | 4 | 8 | 6.2 | CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00249-1 | |||
13822910 | 74538 | 0 | None | - | 0 | Guinea pig | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 383 | 3 | 2 | 2 | 4.7 | O=C1Nc2ccccc2C(c2ccccc2F)=N[C@H]1Cc1c[nH]c2ccccc12 | 10.1021/jm00390a019 | |||
CHEMBL1907930 | 74538 | 0 | None | - | 0 | Guinea pig | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 383 | 3 | 2 | 2 | 4.7 | O=C1Nc2ccccc2C(c2ccccc2F)=N[C@H]1Cc1c[nH]c2ccccc12 | 10.1021/jm00390a019 | |||
44303488 | 107836 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 501 | 8 | 2 | 6 | 4.1 | CC(Cn1nnc2ccccc21)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 | 10.1016/S0960-894X(97)00356-9 | |||
CHEMBL294735 | 107836 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 501 | 8 | 2 | 6 | 4.1 | CC(Cn1nnc2ccccc21)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 | 10.1016/S0960-894X(97)00356-9 | |||
10369806 | 123598 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 532 | 5 | 3 | 3 | 5.6 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@@H](NC(=O)Nc1cccc(Cl)c1)C[C@H]2c1ccccc1 | 10.1021/jm00048a015 | |||
CHEMBL337937 | 123598 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 532 | 5 | 3 | 3 | 5.6 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@@H](NC(=O)Nc1cccc(Cl)c1)C[C@H]2c1ccccc1 | 10.1021/jm00048a015 | |||
CHEMBL218763 | 216178 | 0 | None | -3630 | 4 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm050921q | |||||
44303722 | 107626 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 807 | 20 | 5 | 11 | 4.8 | CCCC[C@@H](C(=O)N[C@@H](CC(=O)OCc1ccccc1)[C@@H](Cc1ccccc1)C(N)=O)n1nnnc1[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)OC(C)(C)C | 10.1016/S0960-894X(01)81005-2 | |||
CHEMBL293456 | 107626 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 807 | 20 | 5 | 11 | 4.8 | CCCC[C@@H](C(=O)N[C@@H](CC(=O)OCc1ccccc1)[C@@H](Cc1ccccc1)C(N)=O)n1nnnc1[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)OC(C)(C)C | 10.1016/S0960-894X(01)81005-2 | |||
11756709 | 29648 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 528 | 9 | 3 | 6 | 3.7 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CCOC(=O)CCC(=O)O)C2=O)c1 | 10.1021/jm00078a018 | |||
CHEMBL132875 | 29648 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 528 | 9 | 3 | 6 | 3.7 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CCOC(=O)CCC(=O)O)C2=O)c1 | 10.1021/jm00078a018 | |||
52949124 | 7663 | 4 | None | -2 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
9055 | 7663 | 4 | None | -2 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
CHEMBL1269258 | 7663 | 4 | None | -2 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
DB12694 | 7663 | 4 | None | -2 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
10435698 | 148186 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 490 | 6 | 2 | 5 | 4.2 | CCOC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(00)80683-6 | |||
CHEMBL38404 | 148186 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 490 | 6 | 2 | 5 | 4.2 | CCOC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(00)80683-6 | |||
44300745 | 205130 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 562 | 6 | 3 | 5 | 5.3 | COC(=O)c1cccc(NC(=O)N[C@@H]2C[C@H](C3CCCCC3)c3ccc(C)cc3N(CC(=O)NC(C)(C)C)C2=O)c1 | 10.1016/0960-894X(95)00327-P | |||
CHEMBL57643 | 205130 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 562 | 6 | 3 | 5 | 5.3 | COC(=O)c1cccc(NC(=O)N[C@@H]2C[C@H](C3CCCCC3)c3ccc(C)cc3N(CC(=O)NC(C)(C)C)C2=O)c1 | 10.1016/0960-894X(95)00327-P | |||
10435698 | 148186 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 490 | 6 | 2 | 5 | 4.2 | CCOC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00121a004 | |||
CHEMBL38404 | 148186 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 490 | 6 | 2 | 5 | 4.2 | CCOC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00121a004 | |||
15104597 | 117327 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 481 | 13 | 2 | 2 | 6.4 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccc(Cl)cc1 | 10.1021/jm00116a002 | |||
CHEMBL325220 | 117327 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 481 | 13 | 2 | 2 | 6.4 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccc(Cl)cc1 | 10.1021/jm00116a002 | |||
11028229 | 122233 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 575 | 8 | 3 | 5 | 4.6 | CO[C@@H]1C[C@H]2[C@H](NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)OC(C)(C)C)CCCN2C(=O)N1Cc1ccccc1 | 10.1021/jm010898i | |||
CHEMBL3350856 | 122233 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 575 | 8 | 3 | 5 | 4.6 | CO[C@@H]1C[C@H]2[C@H](NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)OC(C)(C)C)CCCN2C(=O)N1Cc1ccccc1 | 10.1021/jm010898i | |||
10435698 | 148186 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 490 | 6 | 2 | 5 | 4.2 | CCOC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL38404 | 148186 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 490 | 6 | 2 | 5 | 4.2 | CCOC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
14720390 | 56164 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 373 | 10 | 3 | 3 | 2.8 | CCCN(CCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1cc2ccccc2[nH]1 | 10.1021/jm00164a020 | |||
CHEMBL156415 | 56164 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 373 | 10 | 3 | 3 | 2.8 | CCCN(CCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1cc2ccccc2[nH]1 | 10.1021/jm00164a020 | |||
70695933 | 80411 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 607 | 7 | 1 | 6 | 5.7 | O=C1C(Cc2c[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc2N1CC(=O)N1CCCC1Cc1ccccn1 | 10.1016/j.bmcl.2012.02.049 | |||
CHEMBL2017823 | 80411 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 607 | 7 | 1 | 6 | 5.7 | O=C1C(Cc2c[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc2N1CC(=O)N1CCCC1Cc1ccccn1 | 10.1016/j.bmcl.2012.02.049 | |||
10413618 | 209570 | 0 | None | - | 1 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 499 | 8 | 3 | 3 | 5.4 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 | 10.1016/S0960-894X(01)80769-1 | |||
CHEMBL62205 | 209570 | 0 | None | - | 1 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 499 | 8 | 3 | 3 | 5.4 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 | 10.1016/S0960-894X(01)80769-1 | |||
10323690 | 107274 | 0 | None | - | 2 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 499 | 8 | 3 | 3 | 5.4 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccc1 | 10.1021/jm00057a005 | |||
CHEMBL2114401 | 107274 | 0 | None | - | 2 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 499 | 8 | 3 | 3 | 5.4 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccc1 | 10.1021/jm00057a005 | |||
CHEMBL291033 | 107274 | 0 | None | - | 2 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 499 | 8 | 3 | 3 | 5.4 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccc1 | 10.1021/jm00057a005 | |||
11224455 | 205052 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 440 | 7 | 3 | 3 | 4.1 | CC1=C(C(=O)Nc2ccccc2C(=O)NC(Cc2ccccc2)C(=O)O)Cc2ccccc21 | 10.1016/j.bmc.2009.05.067 | |||
CHEMBL575814 | 205052 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 440 | 7 | 3 | 3 | 4.1 | CC1=C(C(=O)Nc2ccccc2C(=O)NC(Cc2ccccc2)C(=O)O)Cc2ccccc21 | 10.1016/j.bmc.2009.05.067 | |||
44376132 | 127024 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 494 | 6 | 3 | 6 | 3.9 | CC(C)CN1C(=O)[C@H](NC(=O)Nc2ccc(-c3nn[nH]n3)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00032a003 | |||
CHEMBL352264 | 127024 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 494 | 6 | 3 | 6 | 3.9 | CC(C)CN1C(=O)[C@H](NC(=O)Nc2ccc(-c3nn[nH]n3)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00032a003 | |||
90663978 | 113581 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 883 | 23 | 8 | 10 | 3.3 | COc1ccc(/C=C\C(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c(OC)c1 | 10.1021/jm00089a010 | |||
CHEMBL3144542 | 113581 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 883 | 23 | 8 | 10 | 3.3 | COc1ccc(/C=C\C(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c(OC)c1 | 10.1021/jm00089a010 | |||
70695934 | 80419 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 595 | 8 | 1 | 6 | 5.9 | CC(C)N(Cc1ccccc1)C(=O)CN1C(=O)[C@@H](Cc2n[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc21 | 10.1016/j.bmcl.2012.02.049 | |||
CHEMBL2017831 | 80419 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 595 | 8 | 1 | 6 | 5.9 | CC(C)N(Cc1ccccc1)C(=O)CN1C(=O)[C@@H](Cc2n[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc21 | 10.1016/j.bmcl.2012.02.049 | |||
44283029 | 106830 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 627 | 11 | 3 | 7 | 5.2 | COC(=O)/C=C/C(=O)N[C@H](COC(=O)C(C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)c1ccccc1 | 10.1021/jm00086a017 | |||
CHEMBL287079 | 106830 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 627 | 11 | 3 | 7 | 5.2 | COC(=O)/C=C/C(=O)N[C@H](COC(=O)C(C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)c1ccccc1 | 10.1021/jm00086a017 | |||
10793883 | 113907 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 615 | 8 | 0 | 6 | 6.3 | COc1ccc(N(C(=O)CN2C(=O)C(C)(Cc3nn(C)c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm970265x | |||
CHEMBL316104 | 113907 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 615 | 8 | 0 | 6 | 6.3 | COc1ccc(N(C(=O)CN2C(=O)C(C)(Cc3nn(C)c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm970265x | |||
10323690 | 107274 | 0 | None | - | 2 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 499 | 8 | 3 | 3 | 5.4 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccc1 | 10.1021/jm00105a062 | |||
CHEMBL2114401 | 107274 | 0 | None | - | 2 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 499 | 8 | 3 | 3 | 5.4 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccc1 | 10.1021/jm00105a062 | |||
CHEMBL291033 | 107274 | 0 | None | - | 2 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 499 | 8 | 3 | 3 | 5.4 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccc1 | 10.1021/jm00105a062 | |||
14888722 | 84023 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 1055 | 30 | 11 | 14 | -0.2 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@@H](Cc1ccc(Cc2nnn[nH]2)cc1)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00107a037 | |||
CHEMBL2079601 | 84023 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 1055 | 30 | 11 | 14 | -0.2 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@@H](Cc1ccc(Cc2nnn[nH]2)cc1)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00107a037 | |||
44280495 | 105902 | 0 | None | - | 0 | Mouse | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 641 | 10 | 5 | 8 | 3.7 | CN1C(=O)[C@H](NC(=O)Nc2cccc(C(=O)NCCSCc3csc(N=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00248-X | |||
CHEMBL280980 | 105902 | 0 | None | - | 0 | Mouse | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 641 | 10 | 5 | 8 | 3.7 | CN1C(=O)[C@H](NC(=O)Nc2cccc(C(=O)NCCSCc3csc(N=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00248-X | |||
10413618 | 209570 | 0 | None | - | 1 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 499 | 8 | 3 | 3 | 5.4 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 | 10.1021/jm970065l | |||
CHEMBL62205 | 209570 | 0 | None | - | 1 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 499 | 8 | 3 | 3 | 5.4 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 | 10.1021/jm970065l | |||
44349074 | 123814 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 426 | 7 | 4 | 4 | 2.8 | O=C(O)CCC(NC(=O)c1cc2ccccc2[nH]1)C(=O)NN1CCC2(CCCC2)CC1 | 10.1021/jm00079a003 | |||
CHEMBL339041 | 123814 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 426 | 7 | 4 | 4 | 2.8 | O=C(O)CCC(NC(=O)c1cc2ccccc2[nH]1)C(=O)NN1CCC2(CCCC2)CC1 | 10.1021/jm00079a003 | |||
44333305 | 11823 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 502 | 4 | 2 | 5 | 3.6 | CCCN1C(=O)C(NC(=O)Nc2cccc(C(F)(F)F)c2)N=C(N2CCN(C)CC2)c2ccccc21 | 10.1016/0960-894X(95)00530-0 | |||
CHEMBL105273 | 11823 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 502 | 4 | 2 | 5 | 3.6 | CCCN1C(=O)C(NC(=O)Nc2cccc(C(F)(F)F)c2)N=C(N2CCN(C)CC2)c2ccccc21 | 10.1016/0960-894X(95)00530-0 | |||
10430103 | 85289 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 384 | 3 | 3 | 3 | 3.9 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3NC2=O)c1 | 10.1021/jm00078a018 | |||
CHEMBL2111921 | 85289 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 384 | 3 | 3 | 3 | 3.9 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3NC2=O)c1 | 10.1021/jm00078a018 | |||
44281004 | 106855 | 0 | None | - | 1 | Mouse | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 773 | 15 | 4 | 8 | 6.4 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3cccc(OC(=O)NCCCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(96)00249-1 | |||
CHEMBL287295 | 106855 | 0 | None | - | 1 | Mouse | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 773 | 15 | 4 | 8 | 6.4 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3cccc(OC(=O)NCCCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(96)00249-1 | |||
10838382 | 126109 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 478 | 6 | 3 | 4 | 4.5 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NN1CCCCC1 | 10.1021/jm970065l | |||
CHEMBL344211 | 126109 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 478 | 6 | 3 | 4 | 4.5 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NN1CCCCC1 | 10.1021/jm970065l | |||
71449051 | 85260 | 0 | None | - | 0 | Rat | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 455 | 7 | 3 | 4 | 3.6 | O=C(O)CC[C@H](NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)NN1CCC2(CCCC2)CC1 | 10.1021/jm00079a003 | |||
CHEMBL2111827 | 85260 | 0 | None | - | 0 | Rat | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 455 | 7 | 3 | 4 | 3.6 | O=C(O)CC[C@H](NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)NN1CCC2(CCCC2)CC1 | 10.1021/jm00079a003 | |||
44381819 | 65389 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 723 | 20 | 7 | 8 | 3.2 | CCCC[C@H](N[C@@H](C#N)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/S0960-894X(97)00107-8 | |||
CHEMBL168435 | 65389 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 723 | 20 | 7 | 8 | 3.2 | CCCC[C@H](N[C@@H](C#N)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/S0960-894X(97)00107-8 | |||
10322621 | 64332 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 473 | 7 | 2 | 7 | 4.4 | CC(C)Oc1cccc(-n2c(CNC(=O)Nc3ccc([N+](=O)[O-])cc3)nc3ccccc3c2=O)c1 | 10.1016/S0960-894X(97)00108-X | |||
CHEMBL166443 | 64332 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 473 | 7 | 2 | 7 | 4.4 | CC(C)Oc1cccc(-n2c(CNC(=O)Nc3ccc([N+](=O)[O-])cc3)nc3ccccc3c2=O)c1 | 10.1016/S0960-894X(97)00108-X | |||
15514018 | 85371 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 546 | 6 | 3 | 6 | 3.5 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)N(c3ccncc3)C(=O)C[C@H]12 | 10.1021/jm010813d | |||
CHEMBL2112238 | 85371 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 546 | 6 | 3 | 6 | 3.5 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)N(c3ccncc3)C(=O)C[C@H]12 | 10.1021/jm010813d | |||
10580108 | 11883 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 650 | 10 | 1 | 4 | 7.4 | CC(C)N(C(=O)CN1C(=O)C(CC(=O)Nc2ccccc2)(Cc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1021/jm960205b | |||
CHEMBL105619 | 11883 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 650 | 10 | 1 | 4 | 7.4 | CC(C)N(C(=O)CN1C(=O)C(CC(=O)Nc2ccccc2)(Cc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1021/jm960205b | |||
14991574 | 107479 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 836 | 20 | 9 | 8 | 3.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1cc2ccccc2[nH]1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
CHEMBL292471 | 107479 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 836 | 20 | 9 | 8 | 3.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1cc2ccccc2[nH]1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
90663996 | 113602 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 919 | 23 | 9 | 11 | 2.4 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1cccc(OS(=O)(=O)O)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
CHEMBL3144565 | 113602 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 919 | 23 | 9 | 11 | 2.4 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1cccc(OS(=O)(=O)O)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
10415786 | 176497 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 577 | 7 | 3 | 5 | 5.0 | CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccc(O)cc1 | 10.1021/jm950626d | |||
CHEMBL443825 | 176497 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 577 | 7 | 3 | 5 | 5.0 | CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccc(O)cc1 | 10.1021/jm950626d | |||
44336539 | 11916 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 563 | 7 | 2 | 5 | 4.6 | COc1ccc(N(C)C(=O)CN2C(=O)C(NC(=O)Nc3ccccc3)C(=O)N(c3ccccc3)c3ccccc32)cc1 | 10.1016/s0960-894x(98)00548-4 | |||
CHEMBL105775 | 11916 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 563 | 7 | 2 | 5 | 4.6 | COc1ccc(N(C)C(=O)CN2C(=O)C(NC(=O)Nc3ccccc3)C(=O)N(c3ccccc3)c3ccccc32)cc1 | 10.1016/s0960-894x(98)00548-4 | |||
15104612 | 116561 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 514 | 13 | 3 | 4 | 6.0 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccc2cccc(O)c2n1 | 10.1021/jm00116a002 | |||
CHEMBL323249 | 116561 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 514 | 13 | 3 | 4 | 6.0 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccc2cccc(O)c2n1 | 10.1021/jm00116a002 | |||
CHEMBL2370120 | 216565 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | None | None | None | CSCC[C@@H](NC(=O)[C@H](Cc1ccc(CCC(=O)O)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00107a037 | |||||
10318742 | 31779 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 399 | 3 | 2 | 4 | 3.4 | Cc1cccc(NC(=O)NC2N=C(c3ccncc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00078a018 | |||
CHEMBL134657 | 31779 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 399 | 3 | 2 | 4 | 3.4 | Cc1cccc(NC(=O)NC2N=C(c3ccncc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00078a018 | |||
14991542 | 113584 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 893 | 22 | 8 | 8 | 4.2 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCc1ccc(C(F)(F)F)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
CHEMBL3144545 | 113584 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 893 | 22 | 8 | 8 | 4.2 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCc1ccc(C(F)(F)F)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
44280714 | 106809 | 0 | None | - | 1 | Mouse | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 726 | 14 | 6 | 9 | 3.2 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCC(=O)NCCSCc3csc(N=C(N)N)n3)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
CHEMBL286908 | 106809 | 0 | None | - | 1 | Mouse | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 726 | 14 | 6 | 9 | 3.2 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCC(=O)NCCSCc3csc(N=C(N)N)n3)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
5556 | 210039 | 27 | None | - | 1 | Rat | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 342 | 1 | 0 | 4 | 4.2 | Cc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1Cl)=NC2 | 10.1021/jm00396a028 | |||
CHEMBL646 | 210039 | 27 | None | - | 1 | Rat | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 342 | 1 | 0 | 4 | 4.2 | Cc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1Cl)=NC2 | 10.1021/jm00396a028 | |||
13822916 | 196505 | 0 | None | - | 0 | Guinea pig | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 421 | 3 | 1 | 4 | 5.3 | Cc1nnc2n1-c1ccccc1C(c1ccccc1F)=N[C@@H]2Cc1c[nH]c2ccccc12 | 10.1021/jm00390a019 | |||
CHEMBL51569 | 196505 | 0 | None | - | 0 | Guinea pig | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 421 | 3 | 1 | 4 | 5.3 | Cc1nnc2n1-c1ccccc1C(c1ccccc1F)=N[C@@H]2Cc1c[nH]c2ccccc12 | 10.1021/jm00390a019 | |||
44368541 | 175395 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 590 | 13 | 5 | 5 | 4.5 | C[C@H]1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CNC(=O)CCC(=O)O)Cc1ccccc1 | 10.1021/jm00057a005 | |||
CHEMBL436065 | 175395 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 590 | 13 | 5 | 5 | 4.5 | C[C@H]1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CNC(=O)CCC(=O)O)Cc1ccccc1 | 10.1021/jm00057a005 | |||
44286815 | 170047 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 810 | 20 | 7 | 7 | 4.8 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N(C)CCCC(=O)NC(Cc1ccccc1)C(N)=O | 10.1021/jm00037a005 | |||
CHEMBL418622 | 170047 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 810 | 20 | 7 | 7 | 4.8 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N(C)CCCC(=O)NC(Cc1ccccc1)C(N)=O | 10.1021/jm00037a005 | |||
155558199 | 181548 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 1894 | 75 | 19 | 24 | 2.9 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL4561184 | 181548 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 1894 | 75 | 19 | 24 | 2.9 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
10346551 | 121414 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 518 | 5 | 3 | 3 | 5.3 | CC(C)(C)NC(=O)CN1C(=O)[C@H](NC(=O)Nc2ccc(Cl)cc2)C[C@H](c2ccccc2)c2ccccc21 | 10.1021/jm00048a015 | |||
CHEMBL333813 | 121414 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 518 | 5 | 3 | 3 | 5.3 | CC(C)(C)NC(=O)CN1C(=O)[C@H](NC(=O)Nc2ccc(Cl)cc2)C[C@H](c2ccccc2)c2ccccc21 | 10.1021/jm00048a015 | |||
10485763 | 116453 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 860 | 21 | 8 | 8 | 4.2 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)Oc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00028a015 | |||
CHEMBL322635 | 116453 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 860 | 21 | 8 | 8 | 4.2 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)Oc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00028a015 | |||
44381815 | 65781 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 838 | 21 | 7 | 9 | 4.0 | CN(C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCNC(=O)/C=C\c1ccc(O)cc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(N)=O | 10.1016/S0960-894X(00)80680-0 | |||
CHEMBL169126 | 65781 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 838 | 21 | 7 | 9 | 4.0 | CN(C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCNC(=O)/C=C\c1ccc(O)cc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(N)=O | 10.1016/S0960-894X(00)80680-0 | |||
15667003 | 104114 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 1016 | 27 | 8 | 11 | 2.3 | CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC(CCC)[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00094a001 | |||
CHEMBL269355 | 104114 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 1016 | 27 | 8 | 11 | 2.3 | CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC(CCC)[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00094a001 | |||
10346998 | 24882 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 532 | 5 | 2 | 3 | 5.7 | CN(C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](c2ccccc2)c2ccccc21)C(C)(C)C | 10.1021/jm00048a015 | |||
CHEMBL126865 | 24882 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 532 | 5 | 2 | 3 | 5.7 | CN(C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](c2ccccc2)c2ccccc21)C(C)(C)C | 10.1021/jm00048a015 | |||
9962694 | 175013 | 4 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 853 | 21 | 8 | 9 | 3.3 | CN(C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCNC(=O)/C=C/c1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
CHEMBL433640 | 175013 | 4 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 853 | 21 | 8 | 9 | 3.3 | CN(C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCNC(=O)/C=C/c1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
46234969 | 80416 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 626 | 7 | 1 | 5 | 7.4 | O=C1C(Cc2c[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc2N1CC(=O)N1CCCCC1CC1CCCCC1 | 10.1016/j.bmcl.2012.02.049 | |||
CHEMBL2017828 | 80416 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 626 | 7 | 1 | 5 | 7.4 | O=C1C(Cc2c[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc2N1CC(=O)N1CCCCC1CC1CCCCC1 | 10.1016/j.bmcl.2012.02.049 | |||
155548381 | 180511 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 1720 | 69 | 15 | 20 | 3.8 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)[C@@H](C)CC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL4536393 | 180511 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 1720 | 69 | 15 | 20 | 3.8 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)[C@@H](C)CC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL156559 | 215584 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | None | None | None | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00031a013 | |||||
44396672 | 74290 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 545 | 7 | 2 | 6 | 4.5 | CN(C)c1ccc(N2C(=O)CC3[C@@H](N[C@@H](Cc4c[nH]c5ccccc45)C(=O)OC(C)(C)C)CCCN3C2=O)cc1 | 10.1021/jm0498755 | |||
CHEMBL189549 | 74290 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 545 | 7 | 2 | 6 | 4.5 | CN(C)c1ccc(N2C(=O)CC3[C@@H](N[C@@H](Cc4c[nH]c5ccccc45)C(=O)OC(C)(C)C)CCCN3C2=O)cc1 | 10.1021/jm0498755 | |||
10918992 | 86318 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 588 | 7 | 3 | 6 | 4.2 | CN(C)c1ccc(N2C(=O)C[C@H]3[C@H](NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)OC(C)(C)C)CCCN3C2=O)cc1 | 10.1021/jm010813d | |||
CHEMBL2114079 | 86318 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 588 | 7 | 3 | 6 | 4.2 | CN(C)c1ccc(N2C(=O)C[C@H]3[C@H](NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)OC(C)(C)C)CCCN3C2=O)cc1 | 10.1021/jm010813d | |||
13822921 | 108405 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 431 | 3 | 1 | 5 | 4.3 | O=C(NC1N=C(c2ccccc2F)c2ccccc2-n2cnnc21)c1ccc(Cl)cc1 | 10.1021/jm00396a028 | |||
CHEMBL298948 | 108405 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 431 | 3 | 1 | 5 | 4.3 | O=C(NC1N=C(c2ccccc2F)c2ccccc2-n2cnnc21)c1ccc(Cl)cc1 | 10.1021/jm00396a028 | |||
10389657 | 31430 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 462 | 3 | 2 | 3 | 4.4 | CN1C(=O)C(NC(=O)Nc2cccc(Br)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL134340 | 31430 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 462 | 3 | 2 | 3 | 4.4 | CN1C(=O)C(NC(=O)Nc2cccc(Br)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
44329150 | 119178 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 580 | 7 | 3 | 3 | 6.8 | Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)NC3(C)CCCCC3)C2=O)c1 | 10.1016/S0960-894X(01)80832-5 | |||
CHEMBL329735 | 119178 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 580 | 7 | 3 | 3 | 6.8 | Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)NC3(C)CCCCC3)C2=O)c1 | 10.1016/S0960-894X(01)80832-5 | |||
10053472 | 85619 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 557 | 8 | 3 | 4 | 4.1 | CC(C)(C)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm991078x | |||
CHEMBL2112829 | 85619 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 557 | 8 | 3 | 4 | 4.1 | CC(C)(C)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm991078x | |||
52949124 | 7663 | 4 | None | -2 | 2 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
9055 | 7663 | 4 | None | -2 | 2 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
CHEMBL1269258 | 7663 | 4 | None | -2 | 2 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
DB12694 | 7663 | 4 | None | -2 | 2 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
15689726 | 113371 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 880 | 20 | 9 | 8 | 4.6 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1cccc(Cl)c1Cl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||
CHEMBL3142691 | 113371 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 880 | 20 | 9 | 8 | 4.6 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1cccc(Cl)c1Cl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||
44370451 | 57564 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 435 | 15 | 3 | 4 | 4.3 | CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)O)NC(=O)Nc1cccc(OC)c1 | 10.1021/jm00164a020 | |||
CHEMBL157658 | 57564 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 435 | 15 | 3 | 4 | 4.3 | CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)O)NC(=O)Nc1cccc(OC)c1 | 10.1021/jm00164a020 | |||
14991569 | 105575 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 863 | 20 | 9 | 9 | 3.7 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1ccc2cc(O)ccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
CHEMBL278447 | 105575 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 863 | 20 | 9 | 9 | 3.7 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1ccc2cc(O)ccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
14208192 | 109773 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 394 | 3 | 3 | 3 | 3.7 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1cc2ccccc2[nH]1 | 10.1021/jm00047a021 | |||
CHEMBL306760 | 109773 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 394 | 3 | 3 | 3 | 3.7 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1cc2ccccc2[nH]1 | 10.1021/jm00047a021 | |||
14208236 | 211460 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 426 | 3 | 2 | 4 | 3.9 | Cn1c(C(=O)NC2N=C(c3ccccc3F)c3ccccc3NC2=O)cc2ccccc21 | 10.1021/jm00047a021 | |||
CHEMBL73885 | 211460 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 426 | 3 | 2 | 4 | 3.9 | Cn1c(C(=O)NC2N=C(c3ccccc3F)c3ccccc3NC2=O)cc2ccccc21 | 10.1021/jm00047a021 | |||
10030842 | 105369 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 566 | 8 | 4 | 5 | 3.5 | O=C(N[C@H]1C[C@@H]2c3[nH]c4ccccc4c3C[C@@H](C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N2C1=O)OCc1ccccc1 | 10.1021/jm050689o | |||
CHEMBL276837 | 105369 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 566 | 8 | 4 | 5 | 3.5 | O=C(N[C@H]1C[C@@H]2c3[nH]c4ccccc4c3C[C@@H](C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N2C1=O)OCc1ccccc1 | 10.1021/jm050689o | |||
54581302 | 68696 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 572 | 6 | 0 | 7 | 6.0 | COC(=O)c1cc(N2CCN(C(=O)c3ncc(-c4ccc(OC)cc4)c(-c4ccc(C)cc4)n3)CC2)cc2ccccc12 | 10.1016/j.bmcl.2011.03.069 | |||
CHEMBL1774041 | 68696 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 572 | 6 | 0 | 7 | 6.0 | COC(=O)c1cc(N2CCN(C(=O)c3ncc(-c4ccc(OC)cc4)c(-c4ccc(C)cc4)n3)CC2)cc2ccccc12 | 10.1016/j.bmcl.2011.03.069 | |||
15667012 | 175829 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 976 | 28 | 10 | 11 | 1.5 | CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00094a001 | |||
CHEMBL439591 | 175829 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 976 | 28 | 10 | 11 | 1.5 | CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00094a001 | |||
14208192 | 109773 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 394 | 3 | 3 | 3 | 3.7 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1cc2ccccc2[nH]1 | 10.1021/jm00120a002 | |||
CHEMBL306760 | 109773 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 394 | 3 | 3 | 3 | 3.7 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1cc2ccccc2[nH]1 | 10.1021/jm00120a002 | |||
14208236 | 211460 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 426 | 3 | 2 | 4 | 3.9 | Cn1c(C(=O)NC2N=C(c3ccccc3F)c3ccccc3NC2=O)cc2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL73885 | 211460 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 426 | 3 | 2 | 4 | 3.9 | Cn1c(C(=O)NC2N=C(c3ccccc3F)c3ccccc3NC2=O)cc2ccccc21 | 10.1021/jm00120a002 | |||
15667012 | 175829 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 976 | 28 | 10 | 11 | 1.5 | CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00031a013 | |||
CHEMBL439591 | 175829 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 976 | 28 | 10 | 11 | 1.5 | CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00031a013 | |||
10030842 | 105369 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 566 | 8 | 4 | 5 | 3.5 | O=C(N[C@H]1C[C@@H]2c3[nH]c4ccccc4c3C[C@@H](C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N2C1=O)OCc1ccccc1 | 10.1021/jm000959x | |||
CHEMBL276837 | 105369 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 566 | 8 | 4 | 5 | 3.5 | O=C(N[C@H]1C[C@@H]2c3[nH]c4ccccc4c3C[C@@H](C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N2C1=O)OCc1ccccc1 | 10.1021/jm000959x | |||
10030842 | 105369 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 566 | 8 | 4 | 5 | 3.5 | O=C(N[C@H]1C[C@@H]2c3[nH]c4ccccc4c3C[C@@H](C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N2C1=O)OCc1ccccc1 | 10.1016/s0960-894x(01)00630-8 | |||
CHEMBL276837 | 105369 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 566 | 8 | 4 | 5 | 3.5 | O=C(N[C@H]1C[C@@H]2c3[nH]c4ccccc4c3C[C@@H](C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N2C1=O)OCc1ccccc1 | 10.1016/s0960-894x(01)00630-8 | |||
9887120 | 210905 | 4 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00078a018 | |||
CHEMBL70380 | 210905 | 4 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00078a018 | |||
CHEMBL319438 | 217996 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00028a015 | |||||
44348651 | 175016 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 952 | 26 | 11 | 11 | 0.6 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCNC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00099a005 | |||
CHEMBL433647 | 175016 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 952 | 26 | 11 | 11 | 0.6 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCNC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00099a005 | |||
44381578 | 127287 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 840 | 23 | 10 | 10 | 2.9 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(O)cc1)CNN[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/S0960-894X(00)80680-0 | |||
CHEMBL354512 | 127287 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 840 | 23 | 10 | 10 | 2.9 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(O)cc1)CNN[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/S0960-894X(00)80680-0 | |||
90663979 | 113586 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 883 | 23 | 8 | 10 | 3.3 | COc1ccc(/C=C\C(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1OC | 10.1021/jm00089a010 | |||
CHEMBL3144548 | 113586 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 883 | 23 | 8 | 10 | 3.3 | COc1ccc(/C=C\C(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1OC | 10.1021/jm00089a010 | |||
44209151 | 66208 | 1 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 301 | 3 | 2 | 2 | 3.8 | O=C(Cc1ccccc1)Nc1cc2c3ccccc3nc-2c[nH]1 | 10.1016/S0960-894X(00)80682-4 | |||
CHEMBL171108 | 66208 | 1 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 301 | 3 | 2 | 2 | 3.8 | O=C(Cc1ccccc1)Nc1cc2c3ccccc3nc-2c[nH]1 | 10.1016/S0960-894X(00)80682-4 | |||
44336539 | 11916 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 563 | 7 | 2 | 5 | 4.6 | COc1ccc(N(C)C(=O)CN2C(=O)C(NC(=O)Nc3ccccc3)C(=O)N(c3ccccc3)c3ccccc32)cc1 | 10.1016/j.bmcl.2015.03.051 | |||
CHEMBL105775 | 11916 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 563 | 7 | 2 | 5 | 4.6 | COc1ccc(N(C)C(=O)CN2C(=O)C(NC(=O)Nc3ccccc3)C(=O)N(c3ccccc3)c3ccccc32)cc1 | 10.1016/j.bmcl.2015.03.051 | |||
14208245 | 211538 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 389 | 3 | 2 | 3 | 3.9 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccc(Cl)cc1 | 10.1021/jm00047a021 | |||
CHEMBL74580 | 211538 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 389 | 3 | 2 | 3 | 3.9 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccc(Cl)cc1 | 10.1021/jm00047a021 | |||
155553269 | 180906 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 1818 | 68 | 15 | 22 | 3.9 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N1CCC[C@@H]1C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL4545970 | 180906 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 1818 | 68 | 15 | 22 | 3.9 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N1CCC[C@@H]1C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
44348870 | 121606 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 452 | 7 | 3 | 5 | 3.3 | O=C(O)CCC(NC(=O)c1cnc2ccccc2c1)C(=O)NN1CCC2(CCCCC2)CC1 | 10.1021/jm00079a003 | |||
CHEMBL334171 | 121606 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 452 | 7 | 3 | 5 | 3.3 | O=C(O)CCC(NC(=O)c1cnc2ccccc2c1)C(=O)NN1CCC2(CCCCC2)CC1 | 10.1021/jm00079a003 | |||
44348887 | 124867 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 469 | 7 | 3 | 4 | 4.0 | O=C(O)CCC(NC(=O)c1ccc(Cl)c(Cl)c1)C(=O)NN1CCC2(CCCCC2)CC1 | 10.1021/jm00079a003 | |||
CHEMBL340630 | 124867 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 469 | 7 | 3 | 4 | 4.0 | O=C(O)CCC(NC(=O)c1ccc(Cl)c(Cl)c1)C(=O)NN1CCC2(CCCCC2)CC1 | 10.1021/jm00079a003 | |||
880 | 9019 | 5 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 487 | 5 | 3 | 7 | 3.5 | O=C(N[C@@H]1N=C(C2CCCCC2)c2c(N(C1=O)C)cccc2)Nc1cccc(c1)N(c1n[nH]nn1)C | 10.1021/jm9506736 | |||
9935175 | 9019 | 5 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 487 | 5 | 3 | 7 | 3.5 | O=C(N[C@@H]1N=C(C2CCCCC2)c2c(N(C1=O)C)cccc2)Nc1cccc(c1)N(c1n[nH]nn1)C | 10.1021/jm9506736 | |||
CHEMBL2093059 | 9019 | 5 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 487 | 5 | 3 | 7 | 3.5 | O=C(N[C@@H]1N=C(C2CCCCC2)c2c(N(C1=O)C)cccc2)Nc1cccc(c1)N(c1n[nH]nn1)C | 10.1021/jm9506736 | |||
15104628 | 16777 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 534 | 10 | 2 | 5 | 4.6 | CCOC(=O)CN(Cc1ccccc1)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cnc2ccccc2c1 | 10.1021/jm00116a002 | |||
CHEMBL114926 | 16777 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 534 | 10 | 2 | 5 | 4.6 | CCOC(=O)CN(Cc1ccccc1)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cnc2ccccc2c1 | 10.1021/jm00116a002 | |||
10369336 | 123533 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 517 | 7 | 2 | 4 | 4.5 | CCN(CC)C(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL337574 | 123533 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 517 | 7 | 2 | 4 | 4.5 | CCN(CC)C(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
14991535 | 113572 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 841 | 22 | 9 | 9 | 2.9 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCc1cccc(O)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
CHEMBL3144534 | 113572 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 841 | 22 | 9 | 9 | 2.9 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCc1cccc(O)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
44366563 | 126448 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 447 | 6 | 2 | 2 | 5.8 | O=C1C(Cc2c[nH]c3ccccc23)CN(Cc2ccccc2)C[C@@H]1Cc1c[nH]c2ccccc12 | 10.1016/0960-894X(94)80030-8 | |||
CHEMBL347058 | 126448 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 447 | 6 | 2 | 2 | 5.8 | O=C1C(Cc2c[nH]c3ccccc23)CN(Cc2ccccc2)C[C@@H]1Cc1c[nH]c2ccccc12 | 10.1016/0960-894X(94)80030-8 | |||
CHEMBL169054 | 215614 | 0 | None | - | 0 | Guinea pig | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00105a068 | |||||
11200806 | 145143 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 414 | 8 | 3 | 3 | 3.8 | O=C(/C=C/c1ccccc1)Nc1ccccc1C(=O)NC(Cc1ccccc1)C(=O)O | 10.1021/jm051050n | |||
CHEMBL377157 | 145143 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 414 | 8 | 3 | 3 | 3.8 | O=C(/C=C/c1ccccc1)Nc1ccccc1C(=O)NC(Cc1ccccc1)C(=O)O | 10.1021/jm051050n | |||
89913436 | 147566 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 283 | 2 | 1 | 2 | 2.6 | O=C1C=C(Cl)C(O)(c2ccc(Cl)cc2)N1C1CC1 | 10.1039/C6MD00052E | |||
CHEMBL3818705 | 147566 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 283 | 2 | 1 | 2 | 2.6 | O=C1C=C(Cl)C(O)(c2ccc(Cl)cc2)N1C1CC1 | 10.1039/C6MD00052E | |||
15167800 | 39493 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 412 | 4 | 3 | 3 | 4.4 | O=C(NCC1CNc2ccccc2C(c2ccccc2F)=N1)c1cc2ccccc2[nH]1 | 10.1021/jm00163a069 | |||
CHEMBL141365 | 39493 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 412 | 4 | 3 | 3 | 4.4 | O=C(NCC1CNc2ccccc2C(c2ccccc2F)=N1)c1cc2ccccc2[nH]1 | 10.1021/jm00163a069 | |||
10369346 | 31740 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 518 | 6 | 3 | 5 | 4.4 | Cc1ccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)Nc3ccncc3)C2=O)cc1 | 10.1021/jm00078a018 | |||
CHEMBL134618 | 31740 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 518 | 6 | 3 | 5 | 4.4 | Cc1ccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)Nc3ccncc3)C2=O)cc1 | 10.1021/jm00078a018 | |||
CHEMBL169054 | 215614 | 0 | None | - | 0 | Guinea pig | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/S0960-894X(97)00107-8 | |||||
14208211 | 211193 | 0 | None | - | 0 | Rat | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 311 | 2 | 2 | 3 | 2.1 | CC(=O)NC1N=C(c2ccccc2F)c2ccccc2NC1=O | 10.1021/jm00120a002 | |||
CHEMBL72057 | 211193 | 0 | None | - | 0 | Rat | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 311 | 2 | 2 | 3 | 2.1 | CC(=O)NC1N=C(c2ccccc2F)c2ccccc2NC1=O | 10.1021/jm00120a002 | |||
11200806 | 145143 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 414 | 8 | 3 | 3 | 3.8 | O=C(/C=C/c1ccccc1)Nc1ccccc1C(=O)NC(Cc1ccccc1)C(=O)O | 10.1016/j.bmc.2009.05.067 | |||
CHEMBL377157 | 145143 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 414 | 8 | 3 | 3 | 3.8 | O=C(/C=C/c1ccccc1)Nc1ccccc1C(=O)NC(Cc1ccccc1)C(=O)O | 10.1016/j.bmc.2009.05.067 | |||
44300550 | 107673 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 376 | 3 | 2 | 3 | 3.7 | Cc1cccc(NC(=O)NC2N=C(C3CCC3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(01)80987-2 | |||
CHEMBL293786 | 107673 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 376 | 3 | 2 | 3 | 3.7 | Cc1cccc(NC(=O)NC2N=C(C3CCC3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(01)80987-2 | |||
44356801 | 172290 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.6 | C#Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00078a018 | |||
CHEMBL424076 | 172290 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.6 | C#Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00078a018 | |||
10696336 | 212114 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 487 | 5 | 3 | 4 | 4.6 | CCCN1C(=O)[C@H](NC(=O)Nc2ccc3c(c2)CCC3)N=C([C@H]2CC(C)(C)CCN2)c2ccccc21 | 10.1021/jm9608523 | |||
CHEMBL79565 | 212114 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 487 | 5 | 3 | 4 | 4.6 | CCCN1C(=O)[C@H](NC(=O)Nc2ccc3c(c2)CCC3)N=C([C@H]2CC(C)(C)CCN2)c2ccccc21 | 10.1021/jm9608523 | |||
71461592 | 85261 | 0 | None | - | 0 | Rat | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 421 | 7 | 3 | 4 | 3.0 | O=C(O)CC[C@H](NC(=O)c1cccc(Cl)c1)C(=O)NN1CCC2(CCCC2)CC1 | 10.1021/jm00079a003 | |||
CHEMBL2111828 | 85261 | 0 | None | - | 0 | Rat | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 421 | 7 | 3 | 4 | 3.0 | O=C(O)CC[C@H](NC(=O)c1cccc(Cl)c1)C(=O)NN1CCC2(CCCC2)CC1 | 10.1021/jm00079a003 | |||
44357068 | 171661 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 456 | 5 | 3 | 4 | 3.6 | CN1C(=O)C(NC(=O)NCc2cccc(C(C)(C)O)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL422102 | 171661 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 456 | 5 | 3 | 4 | 3.6 | CN1C(=O)C(NC(=O)NCc2cccc(C(C)(C)O)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
44408524 | 162484 | 0 | None | -169 | 4 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 1134 | 30 | 12 | 15 | 2.6 | CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)C(=O)O | 10.1021/jm050851n | |||
CHEMBL405192 | 162484 | 0 | None | -169 | 4 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 1134 | 30 | 12 | 15 | 2.6 | CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)C(=O)O | 10.1021/jm050851n | |||
10323431 | 64526 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 493 | 4 | 3 | 7 | 2.9 | CN1C(=O)[C@H](NC(=O)Nc2ccc3c(c2)N(c2nn[nH]n2)CC3)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm9506736 | |||
CHEMBL166941 | 64526 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 493 | 4 | 3 | 7 | 2.9 | CN1C(=O)[C@H](NC(=O)Nc2ccc3c(c2)N(c2nn[nH]n2)CC3)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm9506736 | |||
10056421 | 113404 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 857 | 21 | 9 | 10 | 3.2 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccc([N+](=O)[O-])cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm960509y | |||
CHEMBL3143025 | 113404 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 857 | 21 | 9 | 10 | 3.2 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccc([N+](=O)[O-])cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm960509y | |||
14208245 | 211538 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 389 | 3 | 2 | 3 | 3.9 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccc(Cl)cc1 | 10.1021/jm00120a002 | |||
CHEMBL74580 | 211538 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 389 | 3 | 2 | 3 | 3.9 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccc(Cl)cc1 | 10.1021/jm00120a002 | |||
CHEMBL317755 | 217984 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | None | None | None | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NS(C)(=O)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00028a015 | |||||
44578772 | 189575 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 486 | 5 | 0 | 5 | 5.5 | COc1cccc(-c2cc(C(=O)N3CCN(c4cccc(Cl)c4)CC3)nn2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
CHEMBL479063 | 189575 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 486 | 5 | 0 | 5 | 5.5 | COc1cccc(-c2cc(C(=O)N3CCN(c4cccc(Cl)c4)CC3)nn2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
52949124 | 7663 | 4 | None | -2 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
9055 | 7663 | 4 | None | -2 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
CHEMBL1269258 | 7663 | 4 | None | -2 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
DB12694 | 7663 | 4 | None | -2 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
44336565 | 115992 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 671 | 8 | 2 | 7 | 5.7 | COc1ccc(N(C)C(=O)CN2C(=O)C(NC(=O)Nc3cccc(C4(C(F)(F)F)N=N4)c3)C(=O)N(c3ccccc3)c3ccccc32)cc1 | 10.1016/s0960-894x(98)00548-4 | |||
CHEMBL321700 | 115992 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 671 | 8 | 2 | 7 | 5.7 | COc1ccc(N(C)C(=O)CN2C(=O)C(NC(=O)Nc3cccc(C4(C(F)(F)F)N=N4)c3)C(=O)N(c3ccccc3)c3ccccc32)cc1 | 10.1016/s0960-894x(98)00548-4 | |||
10346957 | 33726 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 531 | 7 | 2 | 4 | 4.9 | CCN(CC)C(=O)C(C)N1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL136436 | 33726 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 531 | 7 | 2 | 4 | 4.9 | CCN(CC)C(=O)C(C)N1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
10002123 | 85586 | 1 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 418 | 3 | 2 | 3 | 4.3 | CN1C(=O)[C@H](NC(=O)Nc2ccccc2Cl)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL2112748 | 85586 | 1 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 418 | 3 | 2 | 3 | 4.3 | CN1C(=O)[C@H](NC(=O)Nc2ccccc2Cl)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
14991539 | 113571 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 859 | 22 | 8 | 8 | 3.8 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCc1ccc(Cl)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
CHEMBL3144533 | 113571 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 859 | 22 | 8 | 8 | 3.8 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCc1ccc(Cl)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
44366345 | 126263 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 447 | 6 | 2 | 2 | 5.8 | O=C1[C@@H](Cc2c[nH]c3ccccc23)CN(Cc2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 | 10.1016/0960-894X(94)80030-8 | |||
CHEMBL345327 | 126263 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 447 | 6 | 2 | 2 | 5.8 | O=C1[C@@H](Cc2c[nH]c3ccccc23)CN(Cc2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 | 10.1016/0960-894X(94)80030-8 | |||
19766221 | 125667 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 569 | 7 | 3 | 5 | 5.2 | CN1c2ccccc2C(c2ccccc2F)=NCC1CNC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C | 10.1021/jm00163a069 | |||
CHEMBL342256 | 125667 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 569 | 7 | 3 | 5 | 5.2 | CN1c2ccccc2C(c2ccccc2F)=NCC1CNC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C | 10.1021/jm00163a069 | |||
44280116 | 106408 | 0 | None | - | 0 | Mouse | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 672 | 12 | 3 | 6 | 5.8 | CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00248-X | |||
CHEMBL284183 | 106408 | 0 | None | - | 0 | Mouse | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 672 | 12 | 3 | 6 | 5.8 | CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00248-X | |||
10392698 | 124084 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 546 | 5 | 3 | 3 | 5.9 | Cc1ccc([C@H]2C[C@@H](NC(=O)Nc3cccc(Cl)c3)C(=O)N(CC(=O)NC(C)(C)C)c3cc(C)ccc32)cc1 | 10.1021/jm00048a015 | |||
CHEMBL339678 | 124084 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 546 | 5 | 3 | 3 | 5.9 | Cc1ccc([C@H]2C[C@@H](NC(=O)Nc3cccc(Cl)c3)C(=O)N(CC(=O)NC(C)(C)C)c3cc(C)ccc32)cc1 | 10.1021/jm00048a015 | |||
53465906 | 76187 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 456 | 8 | 5 | 4 | 3.7 | O=C(Nc1ccccc1C(=O)NC(CCc1ccccc1)C(=O)NO)c1cc2ccccc2[nH]1 | 10.1021/jm200438b | |||
CHEMBL1933108 | 76187 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 456 | 8 | 5 | 4 | 3.7 | O=C(Nc1ccccc1C(=O)NC(CCc1ccccc1)C(=O)NO)c1cc2ccccc2[nH]1 | 10.1021/jm200438b | |||
44152863 | 127141 | 7 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 475 | 3 | 2 | 2 | 5.9 | O=C1NN(C(=S)Nc2ccc(Cl)c(C(F)(F)F)c2)C(c2ccccc2)C1c1ccccc1 | 10.1016/S0960-894X(00)80684-8 | |||
CHEMBL353189 | 127141 | 7 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 475 | 3 | 2 | 2 | 5.9 | O=C1NN(C(=S)Nc2ccc(Cl)c(C(F)(F)F)c2)C(c2ccccc2)C1c1ccccc1 | 10.1016/S0960-894X(00)80684-8 | |||
71450860 | 85374 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 1147 | 14 | 6 | 10 | 9.0 | CC(C)(C)OC(=O)N[C@@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@@H]12.CC(C)(C)OC(=O)N[C@@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@H]12 | 10.1021/jm991078x | |||
CHEMBL2112273 | 85374 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 1147 | 14 | 6 | 10 | 9.0 | CC(C)(C)OC(=O)N[C@@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@@H]12.CC(C)(C)OC(=O)N[C@@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@H]12 | 10.1021/jm991078x | |||
14208301 | 112431 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 412 | 3 | 1 | 4 | 3.3 | CN1C(=O)C(NC(=O)c2ccc(C#N)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00047a021 | |||
CHEMBL312524 | 112431 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 412 | 3 | 1 | 4 | 3.3 | CN1C(=O)C(NC(=O)c2ccc(C#N)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00047a021 | |||
10555571 | 111354 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 601 | 8 | 0 | 6 | 5.9 | COc1ccc(N(C(=O)CN2C(=O)C(Cc3nn(C)c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm960249k | |||
CHEMBL310466 | 111354 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 601 | 8 | 0 | 6 | 5.9 | COc1ccc(N(C(=O)CN2C(=O)C(Cc3nn(C)c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm960249k | |||
52949124 | 7663 | 4 | None | -2 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
9055 | 7663 | 4 | None | -2 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
CHEMBL1269258 | 7663 | 4 | None | -2 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
DB12694 | 7663 | 4 | None | -2 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
46235271 | 80423 | 2 | None | 2 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 649 | 7 | 1 | 6 | 6.7 | Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1021/acs.jmedchem.5b01110 | |||
CHEMBL2017835 | 80423 | 2 | None | 2 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 649 | 7 | 1 | 6 | 6.7 | Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1021/acs.jmedchem.5b01110 | |||
155533520 | 178607 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 910 | 26 | 8 | 9 | 2.5 | CCCC[C@H](NC(=O)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL4468598 | 178607 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 910 | 26 | 8 | 9 | 2.5 | CCCC[C@H](NC(=O)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
10555571 | 111354 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 601 | 8 | 0 | 6 | 5.9 | COc1ccc(N(C(=O)CN2C(=O)C(Cc3nn(C)c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm970265x | |||
CHEMBL310466 | 111354 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 601 | 8 | 0 | 6 | 5.9 | COc1ccc(N(C(=O)CN2C(=O)C(Cc3nn(C)c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm970265x | |||
10841358 | 214199 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 605 | 8 | 1 | 5 | 6.0 | COc1ccc(N(C(=O)CN2C(=O)C(Cc3n[nH]c4ccc(F)cc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm970265x | |||
CHEMBL94005 | 214199 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 605 | 8 | 1 | 5 | 6.0 | COc1ccc(N(C(=O)CN2C(=O)C(Cc3n[nH]c4ccc(F)cc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm970265x | |||
44334354 | 11393 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 517 | 9 | 2 | 4 | 5.0 | Cc1cccc(NC(=O)N[C@H](COCc2ccccc2)C(=O)N2CCC(C(=O)c3ccc(F)cc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
CHEMBL102879 | 11393 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 517 | 9 | 2 | 4 | 5.0 | Cc1cccc(NC(=O)N[C@H](COCc2ccccc2)C(=O)N2CCC(C(=O)c3ccc(F)cc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
44300744 | 108730 | 0 | None | - | 0 | Guinea pig | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 542 | 6 | 4 | 4 | 4.7 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)O)c1)C[C@@H]2c1ccccc1 | 10.1016/0960-894X(95)00327-P | |||
CHEMBL301261 | 108730 | 0 | None | - | 0 | Guinea pig | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 542 | 6 | 4 | 4 | 4.7 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)O)c1)C[C@@H]2c1ccccc1 | 10.1016/0960-894X(95)00327-P | |||
10623795 | 214063 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 459 | 7 | 3 | 7 | 4.3 | COc1ccccc1NC(=O)NNc1nc2ccccc2c(=O)n1-c1cccc(OC(C)C)c1 | 10.1021/jm970373j | |||
CHEMBL9319 | 214063 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 459 | 7 | 3 | 7 | 4.3 | COc1ccccc1NC(=O)NNc1nc2ccccc2c(=O)n1-c1cccc(OC(C)C)c1 | 10.1021/jm970373j | |||
10478431 | 16671 | 9 | None | - | 0 | Guinea pig | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 440 | 14 | 2 | 3 | 5.0 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1ccc2ccccc2c1 | 10.1021/jm00124a003 | |||
CHEMBL114325 | 16671 | 9 | None | - | 0 | Guinea pig | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 440 | 14 | 2 | 3 | 5.0 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1ccc2ccccc2c1 | 10.1021/jm00124a003 | |||
14519981 | 16832 | 0 | None | - | 0 | Guinea pig | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 441 | 14 | 2 | 4 | 4.4 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1ccc2ccccc2n1 | 10.1021/jm00124a003 | |||
CHEMBL115269 | 16832 | 0 | None | - | 0 | Guinea pig | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 441 | 14 | 2 | 4 | 4.4 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1ccc2ccccc2n1 | 10.1021/jm00124a003 | |||
15104618 | 115818 | 0 | None | - | 0 | Guinea pig | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 496 | 13 | 3 | 2 | 6.8 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)Nc1ccc(Cl)cc1 | 10.1021/jm00116a002 | |||
CHEMBL321265 | 115818 | 0 | None | - | 0 | Guinea pig | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 496 | 13 | 3 | 2 | 6.8 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)Nc1ccc(Cl)cc1 | 10.1021/jm00116a002 | |||
44281078 | 106519 | 0 | None | - | 1 | Mouse | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 773 | 16 | 4 | 8 | 5.9 | CN1C(=O)[C@H](NC(=O)Nc2cccc(CCOC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00249-1 | |||
CHEMBL284975 | 106519 | 0 | None | - | 1 | Mouse | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 773 | 16 | 4 | 8 | 5.9 | CN1C(=O)[C@H](NC(=O)Nc2cccc(CCOC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00249-1 | |||
193319 | 27548 | 5 | None | - | 0 | Rat | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 268 | 1 | 0 | 2 | 2.6 | CN1C(=O)CN=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL13095 | 27548 | 5 | None | - | 0 | Rat | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 268 | 1 | 0 | 2 | 2.6 | CN1C(=O)CN=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL120632 | 215384 | 33 | None | - | 3 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/0960-894X(94)85022-4 | |||||
11729474 | 11443 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 420 | 2 | 2 | 5 | 2.1 | Cc1cccc(NC(=O)NC2N=C(N3CCN(C)CC3)c3ccccc3N(C)C2=O)c1 | 10.1016/0960-894X(95)00530-0 | |||
CHEMBL103229 | 11443 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 420 | 2 | 2 | 5 | 2.1 | Cc1cccc(NC(=O)NC2N=C(N3CCN(C)CC3)c3ccccc3N(C)C2=O)c1 | 10.1016/0960-894X(95)00530-0 | |||
14208302 | 74519 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 412 | 3 | 1 | 4 | 3.3 | CN1C(=O)[C@@H](NC(=O)c2ccc(C#N)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL1907847 | 74519 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 412 | 3 | 1 | 4 | 3.3 | CN1C(=O)[C@@H](NC(=O)c2ccc(C#N)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
24785432 | 188340 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 530 | 7 | 0 | 5 | 6.6 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2ccc(CC)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
CHEMBL476725 | 188340 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 530 | 7 | 0 | 5 | 6.6 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2ccc(CC)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
24785176 | 188342 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 500 | 5 | 0 | 4 | 6.5 | CCc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
CHEMBL476747 | 188342 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 500 | 5 | 0 | 4 | 6.5 | CCc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
CHEMBL169178 | 215616 | 0 | None | - | 0 | Mouse | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | None | None | None | CCOC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N1CC(=O)N[C@@H](Cc2ccccc2)C1 | 10.1016/S0960-894X(01)80253-5 | |||||
15104613 | 117092 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 486 | 13 | 3 | 2 | 6.2 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1c[nH]c2ccccc12 | 10.1021/jm00116a002 | |||
CHEMBL323854 | 117092 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 486 | 13 | 3 | 2 | 6.2 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1c[nH]c2ccccc12 | 10.1021/jm00116a002 | |||
10364355 | 34724 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 412 | 4 | 2 | 3 | 3.9 | C[C@H](NC(=O)NC1N=C(c2ccccc2)c2ccccc2N(C)C1=O)c1ccccc1 | 10.1021/jm00078a018 | |||
CHEMBL137208 | 34724 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 412 | 4 | 2 | 3 | 3.9 | C[C@H](NC(=O)NC1N=C(c2ccccc2)c2ccccc2N(C)C1=O)c1ccccc1 | 10.1021/jm00078a018 | |||
44280266 | 105553 | 0 | None | - | 1 | Mouse | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 729 | 14 | 4 | 7 | 5.0 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
CHEMBL278217 | 105553 | 0 | None | - | 1 | Mouse | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 729 | 14 | 4 | 7 | 5.0 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
108187 | 7713 | 37 | None | 4 | 5 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1016/S0960-894X(00)80273-5 | |||
873 | 7713 | 37 | None | 4 | 5 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1016/S0960-894X(00)80273-5 | |||
CHEMBL2062154 | 7713 | 37 | None | 4 | 5 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1016/S0960-894X(00)80273-5 | |||
CHEMBL287735 | 7713 | 37 | None | 4 | 5 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1016/S0960-894X(00)80273-5 | |||
59923871 | 80735 | 1 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCC(NC(=O)CCC(=O)O)c1ccccc1 | 10.1016/S0960-894X(00)80156-0 | |||
CHEMBL2021374 | 80735 | 1 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCC(NC(=O)CCC(=O)O)c1ccccc1 | 10.1016/S0960-894X(00)80156-0 | |||
108187 | 7713 | 37 | None | 4 | 5 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1021/jm00105a062 | |||
873 | 7713 | 37 | None | 4 | 5 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1021/jm00105a062 | |||
CHEMBL2062154 | 7713 | 37 | None | 4 | 5 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1021/jm00105a062 | |||
CHEMBL287735 | 7713 | 37 | None | 4 | 5 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1021/jm00105a062 | |||
14802537 | 92763 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NC[C@@H](NC(=O)CCC(=O)O)c1ccccc1 | 10.1016/S0960-894X(01)80769-1 | |||
CHEMBL2304062 | 92763 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NC[C@@H](NC(=O)CCC(=O)O)c1ccccc1 | 10.1016/S0960-894X(01)80769-1 | |||
108187 | 7713 | 37 | None | 4 | 5 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1016/S0960-894X(00)80685-X | |||
873 | 7713 | 37 | None | 4 | 5 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1016/S0960-894X(00)80685-X | |||
CHEMBL2062154 | 7713 | 37 | None | 4 | 5 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1016/S0960-894X(00)80685-X | |||
CHEMBL287735 | 7713 | 37 | None | 4 | 5 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1016/S0960-894X(00)80685-X | |||
14802538 | 103464 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCC(=O)O)c1ccccc1 | 10.1016/s0960-894x(98)00677-5 | |||
CHEMBL263969 | 103464 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCC(=O)O)c1ccccc1 | 10.1016/s0960-894x(98)00677-5 | |||
108187 | 7713 | 37 | None | 4 | 5 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1016/S0960-894X(97)00356-9 | |||
873 | 7713 | 37 | None | 4 | 5 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1016/S0960-894X(97)00356-9 | |||
CHEMBL2062154 | 7713 | 37 | None | 4 | 5 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1016/S0960-894X(97)00356-9 | |||
CHEMBL287735 | 7713 | 37 | None | 4 | 5 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1016/S0960-894X(97)00356-9 | |||
44368727 | 126283 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 598 | 12 | 5 | 4 | 4.5 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)C1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1 | 10.1021/jm00057a005 | |||
CHEMBL345511 | 126283 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 598 | 12 | 5 | 4 | 4.5 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)C1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1 | 10.1021/jm00057a005 | |||
44153340 | 38448 | 6 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 413 | 3 | 0 | 4 | 3.8 | CN1c2ccccc2C(c2ccccc2F)=NCC1CN1C(=O)c2ccccc2C1=O | 10.1021/jm00163a069 | |||
CHEMBL140516 | 38448 | 6 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 413 | 3 | 0 | 4 | 3.8 | CN1c2ccccc2C(c2ccccc2F)=NCC1CN1C(=O)c2ccccc2C1=O | 10.1021/jm00163a069 | |||
108187 | 7713 | 37 | None | 4 | 5 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1021/jm970065l | |||
873 | 7713 | 37 | None | 4 | 5 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1021/jm970065l | |||
CHEMBL2062154 | 7713 | 37 | None | 4 | 5 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1021/jm970065l | |||
CHEMBL287735 | 7713 | 37 | None | 4 | 5 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1021/jm970065l | |||
14802539 | 83327 | 1 | None | - | 1 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1 | 10.1016/S0960-894X(00)80652-6 | |||
CHEMBL2062144 | 83327 | 1 | None | - | 1 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1 | 10.1016/S0960-894X(00)80652-6 | |||
136060577 | 94451 | 0 | None | - | 0 | Guinea pig | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 495 | 4 | 1 | 5 | 6.3 | O=C1c2ccccc2C(=O)N1Cc1c(O)ccc2c(/C=C/c3ccccc3)cc3nc4ccccc4n3c12 | 10.1016/j.bmcl.2007.02.071 | |||
CHEMBL233647 | 94451 | 0 | None | - | 0 | Guinea pig | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 495 | 4 | 1 | 5 | 6.3 | O=C1c2ccccc2C(=O)N1Cc1c(O)ccc2c(/C=C/c3ccccc3)cc3nc4ccccc4n3c12 | 10.1016/j.bmcl.2007.02.071 | |||
44369595 | 175306 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 475 | 7 | 2 | 7 | 4.2 | Cc1cccc(NCNC2N=C(c3nccs3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1016/0960-894X(95)00557-A | |||
CHEMBL435447 | 175306 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 475 | 7 | 2 | 7 | 4.2 | Cc1cccc(NCNC2N=C(c3nccs3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1016/0960-894X(95)00557-A | |||
9978270 | 85587 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 399 | 3 | 3 | 4 | 3.2 | CN1C(=O)[C@H](NC(=O)Nc2cccc(N)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL2112749 | 85587 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 399 | 3 | 3 | 4 | 3.2 | CN1C(=O)[C@H](NC(=O)Nc2cccc(N)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
10323637 | 112963 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 498 | 7 | 2 | 5 | 3.6 | CCN(CC)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C)c2)N=C(c2ccccn2)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL313813 | 112963 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 498 | 7 | 2 | 5 | 3.6 | CCN(CC)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C)c2)N=C(c2ccccn2)c2ccccc21 | 10.1021/jm00078a018 | |||
10323637 | 112963 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 498 | 7 | 2 | 5 | 3.6 | CCN(CC)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C)c2)N=C(c2ccccn2)c2ccccc21 | 10.1021/jm9608523 | |||
CHEMBL313813 | 112963 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 498 | 7 | 2 | 5 | 3.6 | CCN(CC)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C)c2)N=C(c2ccccn2)c2ccccc21 | 10.1021/jm9608523 | |||
10973981 | 85208 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 590 | 7 | 3 | 7 | 4.0 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3cccc([N+](=O)[O-])c3)C(=O)C[C@@H]12 | 10.1021/jm010813d | |||
CHEMBL2111548 | 85208 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 590 | 7 | 3 | 7 | 4.0 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3cccc([N+](=O)[O-])c3)C(=O)C[C@@H]12 | 10.1021/jm010813d | |||
46234970 | 80415 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 620 | 7 | 1 | 5 | 6.7 | O=C1C(Cc2c[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc2N1CC(=O)N1CCCCC1Cc1ccccc1 | 10.1016/j.bmcl.2012.02.049 | |||
CHEMBL2017827 | 80415 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 620 | 7 | 1 | 5 | 6.7 | O=C1C(Cc2c[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc2N1CC(=O)N1CCCCC1Cc1ccccc1 | 10.1016/j.bmcl.2012.02.049 | |||
10051431 | 127904 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 494 | 6 | 2 | 4 | 5.1 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 | 10.1016/0960-894X(95)00556-9 | |||
CHEMBL357502 | 127904 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 494 | 6 | 2 | 4 | 5.1 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 | 10.1016/0960-894X(95)00556-9 | |||
44336487 | 117778 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 699 | 9 | 2 | 7 | 6.5 | COc1ccc(N(C(=O)CN2C(=O)C(NC(=O)Nc3cccc(C4(C(F)(F)F)N=N4)c3)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1016/s0960-894x(98)00548-4 | |||
CHEMBL326251 | 117778 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 699 | 9 | 2 | 7 | 6.5 | COc1ccc(N(C(=O)CN2C(=O)C(NC(=O)Nc3cccc(C4(C(F)(F)F)N=N4)c3)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1016/s0960-894x(98)00548-4 | |||
14802525 | 123505 | 1 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 626 | 12 | 5 | 5 | 4.5 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](CNC(=O)/C=C/C(=O)O)Cc1ccccc1 | 10.1021/jm00105a062 | |||
CHEMBL337384 | 123505 | 1 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 626 | 12 | 5 | 5 | 4.5 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](CNC(=O)/C=C/C(=O)O)Cc1ccccc1 | 10.1021/jm00105a062 | |||
44368613 | 127780 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 610 | 12 | 5 | 4 | 4.1 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)C1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CNC(=O)/C=C/C(=O)O)Cc1ccccc1 | 10.1021/jm00057a005 | |||
CHEMBL356419 | 127780 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 610 | 12 | 5 | 4 | 4.1 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)C1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CNC(=O)/C=C/C(=O)O)Cc1ccccc1 | 10.1021/jm00057a005 | |||
73351319 | 174943 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 648 | 12 | 5 | 5 | 5.3 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCP(C)(=O)O)c1ccccc1 | 10.1021/jm00092a007 | |||
CHEMBL433148 | 174943 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 648 | 12 | 5 | 5 | 5.3 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCP(C)(=O)O)c1ccccc1 | 10.1021/jm00092a007 | |||
CHEMBL282175 | 106097 | 0 | None | - | 1 | Mouse | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 769 | 16 | 6 | 11 | 4.6 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CCOC(=O)NCCCC(=O)NCCSCc3csc(C=C(N)N)n3)C2=O)c1 | 10.1016/S0960-894X(96)00249-1 | |||
44591882 | 185754 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 466 | 7 | 5 | 3 | 4.3 | O=C(Nc1ccccc1C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)O)c1cc2ccccc2[nH]1 | 10.1016/j.bmc.2009.02.012 | |||
CHEMBL470622 | 185754 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 466 | 7 | 5 | 3 | 4.3 | O=C(Nc1ccccc1C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)O)c1cc2ccccc2[nH]1 | 10.1016/j.bmc.2009.02.012 | |||
10789229 | 105156 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 440 | 6 | 3 | 7 | 3.8 | CCOc1cccc(-n2c(NNC(=O)Nc3cccc(C#N)c3)nc3ccccc3c2=O)c1 | 10.1021/jm970373j | |||
CHEMBL275307 | 105156 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 440 | 6 | 3 | 7 | 3.8 | CCOc1cccc(-n2c(NNC(=O)Nc3cccc(C#N)c3)nc3ccccc3c2=O)c1 | 10.1021/jm970373j | |||
10091467 | 123483 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 385 | 3 | 2 | 4 | 3.0 | CN1C(=O)C(NC(=O)Nc2ccccn2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL337285 | 123483 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 385 | 3 | 2 | 4 | 3.0 | CN1C(=O)C(NC(=O)Nc2ccccn2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
44362744 | 41444 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 546 | 7 | 4 | 5 | 3.5 | CC(C)(C)OC(=O)N[C@H]1C[C@@H]2c3[nH]c4ccccc4c3C[C@@H](C(=O)N[C@@H](CC(=O)O)Cc3ccccc3)N2C1=O | 10.1016/s0960-894x(98)00677-5 | |||
CHEMBL143012 | 41444 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 546 | 7 | 4 | 5 | 3.5 | CC(C)(C)OC(=O)N[C@H]1C[C@@H]2c3[nH]c4ccccc4c3C[C@@H](C(=O)N[C@@H](CC(=O)O)Cc3ccccc3)N2C1=O | 10.1016/s0960-894x(98)00677-5 | |||
40875375 | 206828 | 1 | None | - | 1 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 480 | 9 | 4 | 3 | 4.8 | O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1c[nH]c2ccccc12)OCc1ccccc1 | 10.1016/S0960-894X(97)00346-6 | |||
CHEMBL59561 | 206828 | 1 | None | - | 1 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 480 | 9 | 4 | 3 | 4.8 | O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1c[nH]c2ccccc12)OCc1ccccc1 | 10.1016/S0960-894X(97)00346-6 | |||
11801355 | 123646 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 580 | 8 | 3 | 6 | 3.6 | COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H]1Cc2c([nH]c3ccccc23)[C@@H]2C[C@@H](NC(=O)OCc3ccccc3)C(=O)N21 | 10.1021/jm000959x | |||
CHEMBL338186 | 123646 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 580 | 8 | 3 | 6 | 3.6 | COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H]1Cc2c([nH]c3ccccc23)[C@@H]2C[C@@H](NC(=O)OCc3ccccc3)C(=O)N21 | 10.1021/jm000959x | |||
44360340 | 39478 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 457 | 5 | 1 | 4 | 5.1 | CN1c2ccccc2C(c2ccccc2F)=NCC1CNC(=O)Cc1cccc2sccc12 | 10.1021/jm00163a069 | |||
CHEMBL141354 | 39478 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 457 | 5 | 1 | 4 | 5.1 | CN1c2ccccc2C(c2ccccc2F)=NCC1CNC(=O)Cc1cccc2sccc12 | 10.1021/jm00163a069 | |||
89913625 | 147539 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 293 | 6 | 1 | 2 | 3.4 | CCCCCCN1C(=O)C=C(Cl)C1(O)c1ccccc1 | 10.1039/C6MD00052E | |||
CHEMBL3818303 | 147539 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 293 | 6 | 1 | 2 | 3.4 | CCCCCCN1C(=O)C=C(Cl)C1(O)c1ccccc1 | 10.1039/C6MD00052E | |||
14802538 | 103464 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCC(=O)O)c1ccccc1 | 10.1021/jm00092a007 | |||
CHEMBL263969 | 103464 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCC(=O)O)c1ccccc1 | 10.1021/jm00092a007 | |||
44334033 | 114582 | 0 | None | - | 0 | Guinea pig | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 475 | 6 | 2 | 4 | 4.7 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC(C(=O)c2ccccc2)CC1 | 10.1016/0960-894X(95)00537-3 | |||
CHEMBL319196 | 114582 | 0 | None | - | 0 | Guinea pig | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 475 | 6 | 2 | 4 | 4.7 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC(C(=O)c2ccccc2)CC1 | 10.1016/0960-894X(95)00537-3 | |||
57390472 | 74529 | 0 | None | - | 0 | Rat | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 431 | 5 | 1 | 4 | 3.3 | COc1cccc(CC(=O)N[C@@H]2N=C(c3ccccc3F)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00120a002 | |||
CHEMBL1907856 | 74529 | 0 | None | - | 0 | Rat | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 431 | 5 | 1 | 4 | 3.3 | COc1cccc(CC(=O)N[C@@H]2N=C(c3ccccc3F)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00120a002 | |||
44359881 | 126080 | 0 | None | - | 0 | Rat | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 473 | 8 | 1 | 5 | 4.1 | CN1c2ccccc2C(c2ccccc2F)=NCC1CNC(=O)CCC(=O)OCc1ccccc1 | 10.1021/jm00163a069 | |||
CHEMBL343969 | 126080 | 0 | None | - | 0 | Rat | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 473 | 8 | 1 | 5 | 4.1 | CN1c2ccccc2C(c2ccccc2F)=NCC1CNC(=O)CCC(=O)OCc1ccccc1 | 10.1021/jm00163a069 | |||
10574611 | 214030 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 429 | 6 | 3 | 6 | 4.3 | CC(C)Oc1cccc(-n2c(NNC(=O)Nc3ccccc3)nc3ccccc3c2=O)c1 | 10.1021/jm970373j | |||
CHEMBL9291 | 214030 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 429 | 6 | 3 | 6 | 4.3 | CC(C)Oc1cccc(-n2c(NNC(=O)Nc3ccccc3)nc3ccccc3c2=O)c1 | 10.1021/jm970373j | |||
CHEMBL171310 | 215626 | 0 | None | - | 0 | Mouse | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N1CC(=O)N[C@H](Cc2ccccc2)C1 | 10.1016/S0960-894X(01)80253-5 | |||||
10010811 | 113385 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 854 | 21 | 9 | 9 | 3.5 | CC(=O)c1ccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 | 10.1021/jm960509y | |||
CHEMBL3142898 | 113385 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 854 | 21 | 9 | 9 | 3.5 | CC(=O)c1ccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 | 10.1021/jm960509y | |||
42636923 | 185610 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 393 | 7 | 4 | 3 | 3.6 | CC(C)C[C@@H](NC(=O)c1ccccc1NC(=O)c1cc2ccccc2[nH]1)C(=O)O | 10.1016/j.bmc.2009.02.012 | |||
CHEMBL469341 | 185610 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 393 | 7 | 4 | 3 | 3.6 | CC(C)C[C@@H](NC(=O)c1ccccc1NC(=O)c1cc2ccccc2[nH]1)C(=O)O | 10.1016/j.bmc.2009.02.012 | |||
15104624 | 16772 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 514 | 13 | 2 | 4 | 5.7 | CCCCCN(CCCCC)C(=O)[C@@H](CC1C(=O)Nc2ccccc21)NC(=O)c1cnc2ccccc2c1 | 10.1021/jm00116a002 | |||
CHEMBL114913 | 16772 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 514 | 13 | 2 | 4 | 5.7 | CCCCCN(CCCCC)C(=O)[C@@H](CC1C(=O)Nc2ccccc21)NC(=O)c1cnc2ccccc2c1 | 10.1021/jm00116a002 | |||
10341040 | 123387 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 402 | 3 | 2 | 3 | 3.8 | CN1C(=O)C(NC(=O)Nc2ccc(F)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL336749 | 123387 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 402 | 3 | 2 | 3 | 3.8 | CN1C(=O)C(NC(=O)Nc2ccc(F)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
44336539 | 11916 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 563 | 7 | 2 | 5 | 4.6 | COc1ccc(N(C)C(=O)CN2C(=O)C(NC(=O)Nc3ccccc3)C(=O)N(c3ccccc3)c3ccccc32)cc1 | 10.1016/j.bmcl.2015.03.051 | |||
CHEMBL105775 | 11916 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 563 | 7 | 2 | 5 | 4.6 | COc1ccc(N(C)C(=O)CN2C(=O)C(NC(=O)Nc3ccccc3)C(=O)N(c3ccccc3)c3ccccc32)cc1 | 10.1016/j.bmcl.2015.03.051 | |||
10393441 | 178492 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 580 | 7 | 3 | 3 | 6.5 | CC(C)(NC(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](c2ccccc2)c2ccccc21)c1ccccc1 | 10.1021/jm00048a015 | |||
CHEMBL446682 | 178492 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 580 | 7 | 3 | 3 | 6.5 | CC(C)(NC(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](c2ccccc2)c2ccccc21)c1ccccc1 | 10.1021/jm00048a015 | |||
44362685 | 128619 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 680 | 12 | 3 | 6 | 5.7 | C[Si](C)(C)CCOC(=O)C[C@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@@H]2C[C@H](NC(=O)OCc3ccccc3)C(=O)N12 | 10.1016/s0960-894x(98)00677-5 | |||
CHEMBL358989 | 128619 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 680 | 12 | 3 | 6 | 5.7 | C[Si](C)(C)CCOC(=O)C[C@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@@H]2C[C@H](NC(=O)OCc3ccccc3)C(=O)N12 | 10.1016/s0960-894x(98)00677-5 | |||
14720386 | 55098 | 0 | None | - | 0 | Guinea pig | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 463 | 12 | 2 | 4 | 4.4 | CCCN(CCC)C(=O)[C@H](CCC(=O)OCc1ccccc1)NC(=O)c1cc2ccccc2[nH]1 | 10.1021/jm00164a020 | |||
CHEMBL155406 | 55098 | 0 | None | - | 0 | Guinea pig | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 463 | 12 | 2 | 4 | 4.4 | CCCN(CCC)C(=O)[C@H](CCC(=O)OCc1ccccc1)NC(=O)c1cc2ccccc2[nH]1 | 10.1021/jm00164a020 | |||
44281005 | 123509 | 0 | None | - | 1 | Mouse | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 787 | 17 | 4 | 8 | 6.4 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CCOC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 | 10.1016/S0960-894X(96)00249-1 | |||
CHEMBL33743 | 123509 | 0 | None | - | 1 | Mouse | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 787 | 17 | 4 | 8 | 6.4 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CCOC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 | 10.1016/S0960-894X(96)00249-1 | |||
44592046 | 185685 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 393 | 6 | 3 | 3 | 4.0 | CC(C)C[C@H](NC(=O)N(C(=O)c1cc2ccccc2[nH]1)c1ccccc1)C(=O)O | 10.1016/j.bmc.2009.02.012 | |||
CHEMBL469980 | 185685 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 393 | 6 | 3 | 3 | 4.0 | CC(C)C[C@H](NC(=O)N(C(=O)c1cc2ccccc2[nH]1)c1ccccc1)C(=O)O | 10.1016/j.bmc.2009.02.012 | |||
10347746 | 23573 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 558 | 6 | 3 | 3 | 6.2 | CC1(NC(=O)CN2C(=O)[C@H](NC(=O)Nc3cccc(Cl)c3)C[C@H](c3ccccc3)c3ccccc32)CCCCC1 | 10.1021/jm00048a015 | |||
CHEMBL124611 | 23573 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 558 | 6 | 3 | 3 | 6.2 | CC1(NC(=O)CN2C(=O)[C@H](NC(=O)Nc3cccc(Cl)c3)C[C@H](c3ccccc3)c3ccccc32)CCCCC1 | 10.1021/jm00048a015 | |||
44368633 | 53319 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 588 | 12 | 5 | 5 | 4.3 | C[C@@H]1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CNC(=O)/C=C/C(=O)O)Cc1ccccc1 | 10.1021/jm00057a005 | |||
CHEMBL153787 | 53319 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 588 | 12 | 5 | 5 | 4.3 | C[C@@H]1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CNC(=O)/C=C/C(=O)O)Cc1ccccc1 | 10.1021/jm00057a005 | |||
115208 | 10590 | 28 | None | -91 | 4 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 393 | 4 | 1 | 4 | 4.0 | O=C(c1ccsc1)NCC1CN=C(c2c(N1C)cccc2)c1ccccc1F | 10.1021/jm00163a069 | |||
1667 | 10590 | 28 | None | -91 | 4 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 393 | 4 | 1 | 4 | 4.0 | O=C(c1ccsc1)NCC1CN=C(c2c(N1C)cccc2)c1ccccc1F | 10.1021/jm00163a069 | |||
CHEMBL169703 | 10590 | 28 | None | -91 | 4 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 393 | 4 | 1 | 4 | 4.0 | O=C(c1ccsc1)NCC1CN=C(c2c(N1C)cccc2)c1ccccc1F | 10.1021/jm00163a069 | |||
10769565 | 24745 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 580 | 8 | 3 | 6 | 3.6 | COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@H]2C[C@H](NC(=O)OCc3ccccc3)C(=O)N12 | 10.1021/jm000959x | |||
CHEMBL126160 | 24745 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 580 | 8 | 3 | 6 | 3.6 | COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@H]2C[C@H](NC(=O)OCc3ccccc3)C(=O)N12 | 10.1021/jm000959x | |||
9982757 | 58245 | 1 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 483 | 5 | 2 | 5 | 4.3 | Cc1cccc(NC(=O)NC2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1016/0960-894X(95)00557-A | |||
CHEMBL158235 | 58245 | 1 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 483 | 5 | 2 | 5 | 4.3 | Cc1cccc(NC(=O)NC2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1016/0960-894X(95)00557-A | |||
44381562 | 175393 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 827 | 22 | 10 | 9 | 3.5 | Cc1ccccc1NC(=O)NCCCC[C@H](NNC[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/S0960-894X(00)80680-0 | |||
CHEMBL436053 | 175393 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 827 | 22 | 10 | 9 | 3.5 | Cc1ccccc1NC(=O)NCCCC[C@H](NNC[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/S0960-894X(00)80680-0 | |||
11505691 | 147703 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 667 | 9 | 2 | 6 | 5.8 | COc1ccc(N(C)C(=O)CN2C(=O)[C@@H](NC(=O)Nc3cccc(C(=O)c4ccccc4)c3)C(=O)N(c3ccccc3)c3ccccc32)cc1 | 10.1021/jm049072h | |||
CHEMBL382263 | 147703 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 667 | 9 | 2 | 6 | 5.8 | COc1ccc(N(C)C(=O)CN2C(=O)[C@@H](NC(=O)Nc3cccc(C(=O)c4ccccc4)c3)C(=O)N(c3ccccc3)c3ccccc32)cc1 | 10.1021/jm049072h | |||
9891461 | 171801 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 483 | 5 | 2 | 5 | 4.3 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1021/jm960669+ | |||
CHEMBL422604 | 171801 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 483 | 5 | 2 | 5 | 4.3 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1021/jm960669+ | |||
15104598 | 116560 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 481 | 13 | 2 | 2 | 6.4 | CCCCCN(CCCCC)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccc(Cl)cc1 | 10.1021/jm00116a002 | |||
CHEMBL323245 | 116560 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 481 | 13 | 2 | 2 | 6.4 | CCCCCN(CCCCC)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccc(Cl)cc1 | 10.1021/jm00116a002 | |||
14208258 | 109733 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 373 | 3 | 2 | 3 | 3.4 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccc(F)cc1 | 10.1021/jm00047a021 | |||
CHEMBL306394 | 109733 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 373 | 3 | 2 | 3 | 3.4 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccc(F)cc1 | 10.1021/jm00047a021 | |||
10769675 | 213978 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 587 | 8 | 1 | 5 | 5.9 | COc1cccc(N(C(=O)CN2C(=O)C(Cc3n[nH]c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)c1 | 10.1021/jm970265x | |||
CHEMBL92586 | 213978 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 587 | 8 | 1 | 5 | 5.9 | COc1cccc(N(C(=O)CN2C(=O)C(Cc3n[nH]c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)c1 | 10.1021/jm970265x | |||
14208200 | 211496 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 422 | 5 | 3 | 3 | 4.0 | O=C(CCc1c[nH]c2ccccc12)NC1N=C(c2ccccc2)c2ccccc2NC1=O | 10.1021/jm00047a021 | |||
CHEMBL74181 | 211496 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 422 | 5 | 3 | 3 | 4.0 | O=C(CCc1c[nH]c2ccccc12)NC1N=C(c2ccccc2)c2ccccc2NC1=O | 10.1021/jm00047a021 | |||
44341613 | 16385 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 516 | 13 | 2 | 3 | 6.4 | CCCCCN(CCCCC)C(=O)[C@H](Cc1c[nH]c2ccc(F)cc12)NC(=O)c1cnc2ccccc2c1 | 10.1021/jm00116a002 | |||
CHEMBL112622 | 16385 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 516 | 13 | 2 | 3 | 6.4 | CCCCCN(CCCCC)C(=O)[C@H](Cc1c[nH]c2ccc(F)cc12)NC(=O)c1cnc2ccccc2c1 | 10.1021/jm00116a002 | |||
52940616 | 24911 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 581 | 7 | 1 | 6 | 5.7 | CC(C)N(Cc1ccccc1)C(=O)CN1C(=O)C(c2n[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc21 | 10.1016/j.bmcl.2010.08.115 | |||
CHEMBL1269263 | 24911 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 581 | 7 | 1 | 6 | 5.7 | CC(C)N(Cc1ccccc1)C(=O)CN1C(=O)C(c2n[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc21 | 10.1016/j.bmcl.2010.08.115 | |||
10453063 | 113768 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 391 | 2 | 2 | 4 | 3.0 | Cc1cccc(NC(=O)NC2N=C(N3CCCC3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00032a002 | |||
CHEMBL315214 | 113768 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 391 | 2 | 2 | 4 | 3.0 | Cc1cccc(NC(=O)NC2N=C(N3CCCC3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00032a002 | |||
21842331 | 50312 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 522 | 7 | 2 | 4 | 5.9 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)CC3CCCCC3)C2=O)c1 | 10.1016/0960-894X(95)00556-9 | |||
CHEMBL150869 | 50312 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 522 | 7 | 2 | 4 | 5.9 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)CC3CCCCC3)C2=O)c1 | 10.1016/0960-894X(95)00556-9 | |||
73349791 | 212586 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 664 | 13 | 5 | 6 | 5.2 | CCOP(=O)(O)CC(=O)N[C@H](CNC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3)c1ccccc1 | 10.1021/jm00092a007 | |||
CHEMBL83244 | 212586 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 664 | 13 | 5 | 6 | 5.2 | CCOP(=O)(O)CC(=O)N[C@H](CNC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3)c1ccccc1 | 10.1021/jm00092a007 | |||
14208258 | 109733 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 373 | 3 | 2 | 3 | 3.4 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccc(F)cc1 | 10.1021/jm00120a002 | |||
CHEMBL306394 | 109733 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 373 | 3 | 2 | 3 | 3.4 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccc(F)cc1 | 10.1021/jm00120a002 | |||
44370461 | 126344 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 488 | 15 | 2 | 4 | 4.8 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)N1CCCC1)NC(=O)Nc1cccc(OC)c1 | 10.1021/jm00164a020 | |||
CHEMBL346070 | 126344 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 488 | 15 | 2 | 4 | 4.8 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)N1CCCC1)NC(=O)Nc1cccc(OC)c1 | 10.1021/jm00164a020 | |||
10453063 | 113768 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 391 | 2 | 2 | 4 | 3.0 | Cc1cccc(NC(=O)NC2N=C(N3CCCC3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm9608523 | |||
CHEMBL315214 | 113768 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 391 | 2 | 2 | 4 | 3.0 | Cc1cccc(NC(=O)NC2N=C(N3CCCC3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm9608523 | |||
14208200 | 211496 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 422 | 5 | 3 | 3 | 4.0 | O=C(CCc1c[nH]c2ccccc12)NC1N=C(c2ccccc2)c2ccccc2NC1=O | 10.1021/jm00120a002 | |||
CHEMBL74181 | 211496 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 422 | 5 | 3 | 3 | 4.0 | O=C(CCc1c[nH]c2ccccc12)NC1N=C(c2ccccc2)c2ccccc2NC1=O | 10.1021/jm00120a002 | |||
19766220 | 38708 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 395 | 4 | 2 | 4 | 3.8 | CN1c2ccccc2C(c2ccccc2F)NCC1CNC(=O)c1ccsc1 | 10.1021/jm00163a069 | |||
CHEMBL140749 | 38708 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 395 | 4 | 2 | 4 | 3.8 | CN1c2ccccc2C(c2ccccc2F)NCC1CNC(=O)c1ccsc1 | 10.1021/jm00163a069 | |||
10323073 | 32183 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 484 | 7 | 2 | 5 | 3.8 | CCOC(=O)CN1C(=O)C(NC(=O)N[C@@H](C)c2ccccc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL134987 | 32183 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 484 | 7 | 2 | 5 | 3.8 | CCOC(=O)CN1C(=O)C(NC(=O)N[C@@H](C)c2ccccc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
44280252 | 106629 | 0 | None | - | 0 | Mouse | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 655 | 11 | 5 | 8 | 3.7 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCSCc3csc(N=C(N)N)n3)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
CHEMBL285746 | 106629 | 0 | None | - | 0 | Mouse | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 655 | 11 | 5 | 8 | 3.7 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCSCc3csc(N=C(N)N)n3)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
6604124 | 62374 | 5 | None | - | 0 | Guinea pig | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 458 | 14 | 2 | 3 | 5.2 | CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)O)NC(=O)c1ccc(Cl)c(Cl)c1 | 10.1021/jm00124a003 | |||
CHEMBL1315743 | 62374 | 5 | None | - | 0 | Guinea pig | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 458 | 14 | 2 | 3 | 5.2 | CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)O)NC(=O)c1ccc(Cl)c(Cl)c1 | 10.1021/jm00124a003 | |||
CHEMBL162111 | 62374 | 5 | None | - | 0 | Guinea pig | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 458 | 14 | 2 | 3 | 5.2 | CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)O)NC(=O)c1ccc(Cl)c(Cl)c1 | 10.1021/jm00124a003 | |||
70682900 | 84624 | 0 | None | - | 0 | Guinea pig | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 385 | 3 | 2 | 3 | 4.6 | O=C1Nc2ccccc2C(c2ccccc2F)=NC1C[C@@H]1CNc2ccccc21 | 10.1021/jm00390a019 | |||
CHEMBL2092991 | 84624 | 0 | None | - | 0 | Guinea pig | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 385 | 3 | 2 | 3 | 4.6 | O=C1Nc2ccccc2C(c2ccccc2F)=NC1C[C@@H]1CNc2ccccc21 | 10.1021/jm00390a019 | |||
20063212 | 173920 | 0 | None | - | 0 | Guinea pig | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 395 | 3 | 0 | 3 | 4.5 | CN1CC(CC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c2ccccc21 | 10.1021/jm00390a019 | |||
CHEMBL429063 | 173920 | 0 | None | - | 0 | Guinea pig | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 395 | 3 | 0 | 3 | 4.5 | CN1CC(CC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c2ccccc21 | 10.1021/jm00390a019 | |||
44349353 | 123620 | 0 | None | - | 0 | Rat | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 415 | 7 | 3 | 4 | 3.0 | Cc1cc(C)cc(C(=O)NC(CCC(=O)O)C(=O)NN2CCC3(CCCC3)CC2)c1 | 10.1021/jm00079a003 | |||
CHEMBL338045 | 123620 | 0 | None | - | 0 | Rat | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 415 | 7 | 3 | 4 | 3.0 | Cc1cc(C)cc(C(=O)NC(CCC(=O)O)C(=O)NN2CCC3(CCCC3)CC2)c1 | 10.1021/jm00079a003 | |||
44381852 | 65817 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 723 | 20 | 7 | 8 | 3.2 | CCCC[C@H](N[C@@H](C#N)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(=O)N[C@@H](Cc1ccccc1)C(N)=O)C(=O)O | 10.1016/S0960-894X(97)00107-8 | |||
CHEMBL169398 | 65817 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 723 | 20 | 7 | 8 | 3.2 | CCCC[C@H](N[C@@H](C#N)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(=O)N[C@@H](Cc1ccccc1)C(N)=O)C(=O)O | 10.1016/S0960-894X(97)00107-8 | |||
44361604 | 38251 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 621 | 8 | 3 | 4 | 4.9 | O=C(N[C@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@@H]12)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C12CC3CC(CC(C3)C1)C2 | 10.1021/jm991078x | |||
CHEMBL140320 | 38251 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 621 | 8 | 3 | 4 | 4.9 | O=C(N[C@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@@H]12)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C12CC3CC(CC(C3)C1)C2 | 10.1021/jm991078x | |||
44381730 | 20736 | 0 | None | - | 0 | Rat | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 450 | 8 | 2 | 4 | 2.5 | CN1CCN(C(=O)CCC(NC(=O)c2cccc(Cl)c2)C(=O)NCCC(C)(C)C)CC1 | 10.1016/S0960-894X(00)80681-2 | |||
CHEMBL1196729 | 20736 | 0 | None | - | 0 | Rat | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 450 | 8 | 2 | 4 | 2.5 | CN1CCN(C(=O)CCC(NC(=O)c2cccc(Cl)c2)C(=O)NCCC(C)(C)C)CC1 | 10.1016/S0960-894X(00)80681-2 | |||
CHEMBL557997 | 20736 | 0 | None | - | 0 | Rat | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 450 | 8 | 2 | 4 | 2.5 | CN1CCN(C(=O)CCC(NC(=O)c2cccc(Cl)c2)C(=O)NCCC(C)(C)C)CC1 | 10.1016/S0960-894X(00)80681-2 | |||
10320031 | 84600 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 421 | 3 | 1 | 3 | 4.0 | CN1C(=O)[C@H](NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL2092868 | 84600 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 421 | 3 | 1 | 3 | 4.0 | CN1C(=O)[C@H](NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
90663981 | 113588 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 891 | 21 | 8 | 8 | 4.6 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(Cl)c(Cl)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
CHEMBL3144550 | 113588 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 891 | 21 | 8 | 8 | 4.6 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(Cl)c(Cl)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
70689603 | 80369 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 588 | 8 | 1 | 6 | 5.5 | COCCC1CCCCN1C(=O)CN1C(=O)C(Cc2c[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc21 | 10.1016/j.bmcl.2012.02.049 | |||
CHEMBL2017690 | 80369 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 588 | 8 | 1 | 6 | 5.5 | COCCC1CCCCN1C(=O)CN1C(=O)C(Cc2c[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc21 | 10.1016/j.bmcl.2012.02.049 | |||
52946666 | 24908 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 600 | 9 | 2 | 7 | 5.6 | CC(C)N(Cc1ccccc1)C(=O)CN1C(=O)C(Nc2cccc(C(=O)O)c2)c2nnc(-c3ccccc3)n2-c2ccccc21 | 10.1016/j.bmcl.2010.08.115 | |||
CHEMBL1269260 | 24908 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 600 | 9 | 2 | 7 | 5.6 | CC(C)N(Cc1ccccc1)C(=O)CN1C(=O)C(Nc2cccc(C(=O)O)c2)c2nnc(-c3ccccc3)n2-c2ccccc21 | 10.1016/j.bmcl.2010.08.115 | |||
44300743 | 107737 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 572 | 6 | 4 | 6 | 4.7 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(-c3nn[nH]n3)c1)C[C@@H]2C1CCCCC1 | 10.1016/0960-894X(95)00327-P | |||
CHEMBL294161 | 107737 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 572 | 6 | 4 | 6 | 4.7 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(-c3nn[nH]n3)c1)C[C@@H]2C1CCCCC1 | 10.1016/0960-894X(95)00327-P | |||
11679146 | 142133 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 667 | 9 | 2 | 6 | 5.8 | COc1ccc(N(C)C(=O)CN2C(=O)[C@H](NC(=O)Nc3cccc(C(=O)c4ccccc4)c3)C(=O)N(c3ccccc3)c3ccccc32)cc1 | 10.1021/jm049072h | |||
CHEMBL372773 | 142133 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 667 | 9 | 2 | 6 | 5.8 | COc1ccc(N(C)C(=O)CN2C(=O)[C@H](NC(=O)Nc3cccc(C(=O)c4ccccc4)c3)C(=O)N(c3ccccc3)c3ccccc32)cc1 | 10.1021/jm049072h | |||
11741582 | 34734 | 9 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 398 | 4 | 2 | 3 | 3.3 | CN1C(=O)C(NC(=O)NCc2ccccc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL137213 | 34734 | 9 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 398 | 4 | 2 | 3 | 3.3 | CN1C(=O)C(NC(=O)NCc2ccccc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
10029145 | 104946 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 504 | 7 | 2 | 5 | 4.6 | CCOC(=O)CCN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL273919 | 104946 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 504 | 7 | 2 | 5 | 4.6 | CCOC(=O)CCN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
10693825 | 213835 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 428 | 5 | 3 | 6 | 3.9 | Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(N(C)C)c2)c1 | 10.1021/jm970373j | |||
CHEMBL9171 | 213835 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 428 | 5 | 3 | 6 | 3.9 | Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(N(C)C)c2)c1 | 10.1021/jm970373j | |||
6604124 | 62374 | 5 | None | - | 0 | Guinea pig | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 458 | 14 | 2 | 3 | 5.2 | CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)O)NC(=O)c1ccc(Cl)c(Cl)c1 | 10.1021/jm00124a003 | |||
CHEMBL1315743 | 62374 | 5 | None | - | 0 | Guinea pig | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 458 | 14 | 2 | 3 | 5.2 | CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)O)NC(=O)c1ccc(Cl)c(Cl)c1 | 10.1021/jm00124a003 | |||
CHEMBL162111 | 62374 | 5 | None | - | 0 | Guinea pig | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 458 | 14 | 2 | 3 | 5.2 | CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)O)NC(=O)c1ccc(Cl)c(Cl)c1 | 10.1021/jm00124a003 | |||
10528637 | 104079 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 477 | 6 | 3 | 7 | 4.4 | CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(Cl)c2)c1 | 10.1021/jm970373j | |||
CHEMBL269123 | 104079 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 477 | 6 | 3 | 7 | 4.4 | CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(Cl)c2)c1 | 10.1021/jm970373j | |||
14208229 | 109945 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 430 | 3 | 3 | 3 | 4.0 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1cc2cc(F)ccc2[nH]1 | 10.1021/jm00120a002 | |||
CHEMBL308111 | 109945 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 430 | 3 | 3 | 3 | 4.0 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1cc2cc(F)ccc2[nH]1 | 10.1021/jm00120a002 | |||
14208229 | 109945 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 430 | 3 | 3 | 3 | 4.0 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1cc2cc(F)ccc2[nH]1 | 10.1021/jm00047a021 | |||
CHEMBL308111 | 109945 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 430 | 3 | 3 | 3 | 4.0 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1cc2cc(F)ccc2[nH]1 | 10.1021/jm00047a021 | |||
44306823 | 209846 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 802 | 20 | 9 | 7 | 2.8 | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NC(CCCCNC(=O)Nc1ccccc1Cl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccc(C)cc1)C(N)=O | 10.1021/jm00001a027 | |||
CHEMBL63707 | 209846 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 802 | 20 | 9 | 7 | 2.8 | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NC(CCCCNC(=O)Nc1ccccc1Cl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccc(C)cc1)C(N)=O | 10.1021/jm00001a027 | |||
3081191 | 16320 | 14 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 441 | 14 | 2 | 4 | 4.4 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1cnc2ccccc2c1 | 10.1021/jm00124a003 | |||
CHEMBL112307 | 16320 | 14 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 441 | 14 | 2 | 4 | 4.4 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1cnc2ccccc2c1 | 10.1021/jm00124a003 | |||
3081191 | 16320 | 14 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 441 | 14 | 2 | 4 | 4.4 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1cnc2ccccc2c1 | 10.1021/jm00116a002 | |||
CHEMBL112307 | 16320 | 14 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 441 | 14 | 2 | 4 | 4.4 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1cnc2ccccc2c1 | 10.1021/jm00116a002 | |||
44293812 | 108492 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 645 | 5 | 2 | 4 | 5.9 | Cc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(Br)c1)N=C2c1ccccc1F | 10.1016/S0960-894X(96)00609-9 | |||
CHEMBL299523 | 108492 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 645 | 5 | 2 | 4 | 5.9 | Cc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(Br)c1)N=C2c1ccccc1F | 10.1016/S0960-894X(96)00609-9 | |||
11027990 | 74306 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 545 | 6 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm0501127 | |||
CHEMBL189634 | 74306 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 545 | 6 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(c3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm0501127 | |||
44330874 | 215141 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 974 | 28 | 10 | 11 | 2.1 | CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N/C(=C\c1ccccc1)C(N)=O | 10.1021/jm00094a001 | |||
CHEMBL99499 | 215141 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 974 | 28 | 10 | 11 | 2.1 | CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N/C(=C\c1ccccc1)C(N)=O | 10.1021/jm00094a001 | |||
10056407 | 126926 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 854 | 20 | 7 | 8 | 4.2 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00031a013 | |||
CHEMBL351364 | 126926 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 854 | 20 | 7 | 8 | 4.2 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00031a013 | |||
CHEMBL318570 | 217994 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | None | None | None | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00028a015 | |||||
CHEMBL438911 | 220585 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00100a033 | |||||
24785180 | 188319 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 536 | 6 | 0 | 5 | 6.7 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2ccc(Cl)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
CHEMBL476531 | 188319 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 536 | 6 | 0 | 5 | 6.7 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2ccc(Cl)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
11803697 | 113393 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 857 | 21 | 9 | 10 | 3.2 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1cccc([N+](=O)[O-])c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm960509y | |||
136898911 | 113393 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 857 | 21 | 9 | 10 | 3.2 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1cccc([N+](=O)[O-])c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm960509y | |||
CHEMBL3142912 | 113393 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 857 | 21 | 9 | 10 | 3.2 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1cccc([N+](=O)[O-])c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm960509y | |||
15667013 | 114183 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 920 | 26 | 10 | 11 | 0.1 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)CNC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00094a001 | |||
CHEMBL318010 | 114183 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 920 | 26 | 10 | 11 | 0.1 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)CNC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00094a001 | |||
CHEMBL319439 | 217997 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | None | None | None | CNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00028a015 | |||||
3960 | 9124 | 23 | None | - | 1 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 458 | 14 | 2 | 3 | 5.2 | CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCCC | 10.1021/jm00079a003 | |||
891 | 9124 | 23 | None | - | 1 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 458 | 14 | 2 | 3 | 5.2 | CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCCC | 10.1021/jm00079a003 | |||
CHEMBL24938 | 9124 | 23 | None | - | 1 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 458 | 14 | 2 | 3 | 5.2 | CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCCC | 10.1021/jm00079a003 | |||
44349077 | 124619 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 458 | 14 | 2 | 3 | 5.2 | CCCCCN(CCCCC)C(=O)C(CCC(=O)O)NC(=O)c1cc(Cl)cc(Cl)c1 | 10.1021/jm00079a003 | |||
CHEMBL340263 | 124619 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 458 | 14 | 2 | 3 | 5.2 | CCCCCN(CCCCC)C(=O)C(CCC(=O)O)NC(=O)c1cc(Cl)cc(Cl)c1 | 10.1021/jm00079a003 | |||
10483574 | 12978 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 591 | 8 | 2 | 5 | 5.3 | COc1ccc(N(C(=O)CN2C(=O)C(NC(=O)Nc3ccccc3)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1016/s0960-894x(98)00548-4 | |||
CHEMBL108130 | 12978 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 591 | 8 | 2 | 5 | 5.3 | COc1ccc(N(C(=O)CN2C(=O)C(NC(=O)Nc3ccccc3)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1016/s0960-894x(98)00548-4 | |||
13605417 | 214347 | 4 | None | - | 1 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 458 | 14 | 2 | 3 | 5.2 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/S0960-894X(00)80681-2 | |||
CHEMBL9485 | 214347 | 4 | None | - | 1 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 458 | 14 | 2 | 3 | 5.2 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/S0960-894X(00)80681-2 | |||
10458620 | 121324 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 499 | 5 | 2 | 4 | 5.4 | Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)c3ccccc3N(CC(=O)OC(C)(C)C)C2=O)c1 | 10.1021/jm00048a015 | |||
CHEMBL333718 | 121324 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 499 | 5 | 2 | 4 | 5.4 | Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)c3ccccc3N(CC(=O)OC(C)(C)C)C2=O)c1 | 10.1021/jm00048a015 | |||
13605417 | 214347 | 4 | None | - | 1 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 458 | 14 | 2 | 3 | 5.2 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/S0960-894X(00)80687-3 | |||
CHEMBL9485 | 214347 | 4 | None | - | 1 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 458 | 14 | 2 | 3 | 5.2 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/S0960-894X(00)80687-3 | |||
14991580 | 107484 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 829 | 21 | 8 | 9 | 3.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C/c1cccs1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
CHEMBL292490 | 107484 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 829 | 21 | 8 | 9 | 3.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C/c1cccs1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
10507109 | 116004 | 0 | None | -1 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 561 | 7 | 2 | 4 | 5.3 | CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1021/jm9601664 | |||
CHEMBL321761 | 116004 | 0 | None | -1 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 561 | 7 | 2 | 4 | 5.3 | CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1021/jm9601664 | |||
10507109 | 116004 | 0 | None | -1 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 561 | 7 | 2 | 4 | 5.3 | CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1021/jm950626d | |||
CHEMBL321761 | 116004 | 0 | None | -1 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 561 | 7 | 2 | 4 | 5.3 | CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1021/jm950626d | |||
10507109 | 116004 | 0 | None | -1 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 561 | 7 | 2 | 4 | 5.3 | CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1016/S0960-894X(97)00062-0 | |||
CHEMBL321761 | 116004 | 0 | None | -1 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 561 | 7 | 2 | 4 | 5.3 | CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1016/S0960-894X(97)00062-0 | |||
44336539 | 11916 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 563 | 7 | 2 | 5 | 4.6 | COc1ccc(N(C)C(=O)CN2C(=O)C(NC(=O)Nc3ccccc3)C(=O)N(c3ccccc3)c3ccccc32)cc1 | 10.1016/j.bmcl.2015.03.051 | |||
CHEMBL105775 | 11916 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 563 | 7 | 2 | 5 | 4.6 | COc1ccc(N(C)C(=O)CN2C(=O)C(NC(=O)Nc3ccccc3)C(=O)N(c3ccccc3)c3ccccc32)cc1 | 10.1016/j.bmcl.2015.03.051 | |||
11039204 | 85365 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 588 | 7 | 3 | 6 | 4.2 | CN(C)c1cccc(N2C(=O)C[C@H]3[C@H](NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)OC(C)(C)C)CCCN3C2=O)c1 | 10.1021/jm010813d | |||
CHEMBL2112231 | 85365 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 588 | 7 | 3 | 6 | 4.2 | CN(C)c1cccc(N2C(=O)C[C@H]3[C@H](NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)OC(C)(C)C)CCCN3C2=O)c1 | 10.1021/jm010813d | |||
14208265 | 211288 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 423 | 3 | 2 | 3 | 4.5 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1cc(Cl)cc(Cl)c1 | 10.1021/jm00120a002 | |||
CHEMBL72616 | 211288 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 423 | 3 | 2 | 3 | 4.5 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1cc(Cl)cc(Cl)c1 | 10.1021/jm00120a002 | |||
14802530 | 28389 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 614 | 12 | 5 | 5 | 4.3 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](CNC(=O)CC(=O)O)Cc1ccccc1 | 10.1021/jm00105a062 | |||
CHEMBL131754 | 28389 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 614 | 12 | 5 | 5 | 4.3 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](CNC(=O)CC(=O)O)Cc1ccccc1 | 10.1021/jm00105a062 | |||
15104607 | 170192 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 497 | 13 | 2 | 2 | 6.9 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cccc2ccccc12 | 10.1021/jm00116a002 | |||
CHEMBL419585 | 170192 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 497 | 13 | 2 | 2 | 6.9 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cccc2ccccc12 | 10.1021/jm00116a002 | |||
44334305 | 116496 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 514 | 9 | 3 | 4 | 4.6 | Cc1cccc(NC(=O)N[C@H](COCc2ccccc2)C(=O)N2CCC(C(=O)Nc3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
CHEMBL322913 | 116496 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 514 | 9 | 3 | 4 | 4.6 | Cc1cccc(NC(=O)N[C@H](COCc2ccccc2)C(=O)N2CCC(C(=O)Nc3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
101918113 | 122192 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 650 | 14 | 6 | 7 | 0.7 | CS[C@H]1C[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)N(C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(C)=O)C1 | 10.1021/jm00001a019 | |||
CHEMBL3350334 | 122192 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 650 | 14 | 6 | 7 | 0.7 | CS[C@H]1C[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)N(C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(C)=O)C1 | 10.1021/jm00001a019 | |||
CHEMBL407736 | 219459 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(N)=O | 10.1021/jm00378a012 | |||||
44211354 | 19636 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 536 | 6 | 1 | 4 | 4.2 | CN1CCN(C(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCCC3)CC2)CC1 | 10.1016/S0960-894X(00)80681-2 | |||
CHEMBL1188705 | 19636 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 536 | 6 | 1 | 4 | 4.2 | CN1CCN(C(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCCC3)CC2)CC1 | 10.1016/S0960-894X(00)80681-2 | |||
CHEMBL537171 | 19636 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 536 | 6 | 1 | 4 | 4.2 | CN1CCN(C(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCCC3)CC2)CC1 | 10.1016/S0960-894X(00)80681-2 | |||
44280740 | 107183 | 0 | None | - | 1 | Mouse | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 787 | 17 | 4 | 8 | 6.3 | CN1C(=O)[C@H](NC(=O)Nc2cccc(CCOC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00249-1 | |||
CHEMBL290122 | 107183 | 0 | None | - | 1 | Mouse | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 787 | 17 | 4 | 8 | 6.3 | CN1C(=O)[C@H](NC(=O)Nc2cccc(CCOC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00249-1 | |||
CHEMBL289310 | 217650 | 0 | None | - | 0 | Rat | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(N)=O | 10.1021/jm00378a012 | |||||
20063240 | 20422 | 0 | None | - | 0 | Guinea pig | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 480 | 6 | 2 | 4 | 4.7 | CC(C)CC(N)C(=O)N1CC(CC2N=C(c3ccccc3)c3ccccc3NC2=O)c2ccccc21 | 10.1021/jm00390a019 | |||
CHEMBL1194526 | 20422 | 0 | None | - | 0 | Guinea pig | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 480 | 6 | 2 | 4 | 4.7 | CC(C)CC(N)C(=O)N1CC(CC2N=C(c3ccccc3)c3ccccc3NC2=O)c2ccccc21 | 10.1021/jm00390a019 | |||
CHEMBL552817 | 20422 | 0 | None | - | 0 | Guinea pig | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 480 | 6 | 2 | 4 | 4.7 | CC(C)CC(N)C(=O)N1CC(CC2N=C(c3ccccc3)c3ccccc3NC2=O)c2ccccc21 | 10.1021/jm00390a019 | |||
15614807 | 74501 | 1 | None | - | 0 | Guinea pig | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 365 | 3 | 2 | 2 | 4.6 | O=C1Nc2ccccc2C(c2ccccc2)=N[C@@H]1Cc1c[nH]c2ccccc12 | 10.1021/jm00390a019 | |||
CHEMBL1907740 | 74501 | 1 | None | - | 0 | Guinea pig | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 365 | 3 | 2 | 2 | 4.6 | O=C1Nc2ccccc2C(c2ccccc2)=N[C@@H]1Cc1c[nH]c2ccccc12 | 10.1021/jm00390a019 | |||
14208265 | 211288 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 423 | 3 | 2 | 3 | 4.5 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1cc(Cl)cc(Cl)c1 | 10.1021/jm00047a021 | |||
CHEMBL72616 | 211288 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 423 | 3 | 2 | 3 | 4.5 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1cc(Cl)cc(Cl)c1 | 10.1021/jm00047a021 | |||
887 | 10882 | 33 | None | - | 4 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 498 | 6 | 3 | 6 | 4.1 | CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 | 10.1021/jm960669+ | |||
9870520 | 10882 | 33 | None | - | 4 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 498 | 6 | 3 | 6 | 4.1 | CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 | 10.1021/jm960669+ | |||
CHEMBL324547 | 10882 | 33 | None | - | 4 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 498 | 6 | 3 | 6 | 4.1 | CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 | 10.1021/jm960669+ | |||
DB12355 | 10882 | 33 | None | - | 4 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 498 | 6 | 3 | 6 | 4.1 | CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 | 10.1021/jm960669+ | |||
10649606 | 56390 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 519 | 6 | 3 | 4 | 4.5 | O=C(CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)Nc1ccccc1 | 10.1016/j.bmcl.2015.03.051 | |||
CHEMBL156605 | 56390 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 519 | 6 | 3 | 4 | 4.5 | O=C(CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)Nc1ccccc1 | 10.1016/j.bmcl.2015.03.051 | |||
CHEMBL3142692 | 217911 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | None | None | None | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1cccc(Cl)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||||
10070677 | 168503 | 15 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 418 | 3 | 2 | 3 | 4.3 | CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00121a004 | |||
CHEMBL41361 | 168503 | 15 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 418 | 3 | 2 | 3 | 4.3 | CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00121a004 | |||
10649606 | 56390 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 519 | 6 | 3 | 4 | 4.5 | O=C(CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)Nc1ccccc1 | 10.1016/j.bmcl.2015.03.051 | |||
CHEMBL156605 | 56390 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 519 | 6 | 3 | 4 | 4.5 | O=C(CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)Nc1ccccc1 | 10.1016/j.bmcl.2015.03.051 | |||
54580263 | 68631 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 519 | 5 | 0 | 6 | 5.5 | COc1ccc(-c2cnc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2cccc(F)c2)cc1 | 10.1016/j.bmcl.2011.03.069 | |||
CHEMBL1773878 | 68631 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 519 | 5 | 0 | 6 | 5.5 | COc1ccc(-c2cnc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2cccc(F)c2)cc1 | 10.1016/j.bmcl.2011.03.069 | |||
15104611 | 116034 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 514 | 13 | 3 | 4 | 6.0 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cc(O)c2ccccc2n1 | 10.1021/jm00116a002 | |||
CHEMBL321811 | 116034 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 514 | 13 | 3 | 4 | 6.0 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cc(O)c2ccccc2n1 | 10.1021/jm00116a002 | |||
15104601 | 177208 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 486 | 13 | 3 | 2 | 6.2 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cc2ccccc2[nH]1 | 10.1021/jm00116a002 | |||
CHEMBL444847 | 177208 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 486 | 13 | 3 | 2 | 6.2 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cc2ccccc2[nH]1 | 10.1021/jm00116a002 | |||
CHEMBL99786 | 222708 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | None | None | None | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00173a006 | |||||
73355867 | 213039 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 680 | 12 | 5 | 6 | 6.5 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CSc1ccccc1O)c1ccccc1 | 10.1021/jm00092a007 | |||
CHEMBL86879 | 213039 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 680 | 12 | 5 | 6 | 6.5 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CSc1ccccc1O)c1ccccc1 | 10.1021/jm00092a007 | |||
10501974 | 103750 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 415 | 5 | 3 | 6 | 3.9 | COc1cccc(-n2c(NNC(=O)Nc3cccc(C)c3)nc3ccccc3c2=O)c1 | 10.1021/jm970373j | |||
CHEMBL266376 | 103750 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 415 | 5 | 3 | 6 | 3.9 | COc1cccc(-n2c(NNC(=O)Nc3cccc(C)c3)nc3ccccc3c2=O)c1 | 10.1021/jm970373j | |||
CHEMBL436451 | 220460 | 0 | None | - | 0 | Mouse | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N1C[C@H](Cc2ccccc2)NC(=O)[C@@H]1CC(=O)O | 10.1016/S0960-894X(01)80253-5 | |||||
44368522 | 126259 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 574 | 11 | 5 | 5 | 4.4 | C[C@H]1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)NC[C@H](NC(=O)/C=C/C(=O)O)c1ccccc1 | 10.1021/jm00057a005 | |||
CHEMBL345303 | 126259 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 574 | 11 | 5 | 5 | 4.4 | C[C@H]1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)NC[C@H](NC(=O)/C=C/C(=O)O)c1ccccc1 | 10.1021/jm00057a005 | |||
CHEMBL382349 | 219081 | 0 | None | -3235 | 4 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm050921q | |||||
44336539 | 11916 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 563 | 7 | 2 | 5 | 4.6 | COc1ccc(N(C)C(=O)CN2C(=O)C(NC(=O)Nc3ccccc3)C(=O)N(c3ccccc3)c3ccccc32)cc1 | 10.1016/j.bmcl.2015.03.051 | |||
CHEMBL105775 | 11916 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 563 | 7 | 2 | 5 | 4.6 | COc1ccc(N(C)C(=O)CN2C(=O)C(NC(=O)Nc3ccccc3)C(=O)N(c3ccccc3)c3ccccc32)cc1 | 10.1016/j.bmcl.2015.03.051 | |||
44591825 | 190885 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 411 | 8 | 4 | 4 | 3.4 | CSCCC(NC(=O)c1ccccc1NC(=O)c1cc2ccccc2[nH]1)C(=O)O | 10.1016/j.bmc.2009.02.012 | |||
CHEMBL482571 | 190885 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 411 | 8 | 4 | 4 | 3.4 | CSCCC(NC(=O)c1ccccc1NC(=O)c1cc2ccccc2[nH]1)C(=O)O | 10.1016/j.bmc.2009.02.012 | |||
14991576 | 108991 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 866 | 21 | 9 | 9 | 3.4 | COc1ccc2[nH]c(C(=O)NCCCC[C@H](NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc3ccccc3)C(N)=O)cc2c1 | 10.1021/jm00089a010 | |||
CHEMBL302911 | 108991 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 866 | 21 | 9 | 9 | 3.4 | COc1ccc2[nH]c(C(=O)NCCCC[C@H](NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc3ccccc3)C(N)=O)cc2c1 | 10.1021/jm00089a010 | |||
51353551 | 24906 | 16 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 605 | 8 | 3 | 5 | 5.0 | CC(C)N(C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(C(=O)O)c2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1016/j.bmcl.2010.08.115 | |||
CHEMBL1269257 | 24906 | 16 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 605 | 8 | 3 | 5 | 5.0 | CC(C)N(C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(C(=O)O)c2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1016/j.bmcl.2010.08.115 | |||
10414170 | 177397 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 515 | 5 | 2 | 4 | 4.3 | O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N2CCCC2)C1=O | 10.1016/S0960-894X(00)80683-6 | |||
CHEMBL445095 | 177397 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 515 | 5 | 2 | 4 | 4.3 | O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N2CCCC2)C1=O | 10.1016/S0960-894X(00)80683-6 | |||
44300989 | 107757 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 625 | 7 | 4 | 6 | 4.2 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)NS(C)(=O)=O)c1)C[C@@H]2C1CCCCC1 | 10.1016/0960-894X(95)00327-P | |||
CHEMBL294252 | 107757 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 625 | 7 | 4 | 6 | 4.2 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)NS(C)(=O)=O)c1)C[C@@H]2C1CCCCC1 | 10.1016/0960-894X(95)00327-P | |||
44382624 | 127137 | 0 | None | - | 0 | Mouse | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 619 | 12 | 4 | 4 | 4.0 | CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)/C=C/c1ccccc1)C(=O)N1CC(=O)N[C@@H](Cc2ccccc2)C1 | 10.1016/S0960-894X(01)80253-5 | |||
CHEMBL353148 | 127137 | 0 | None | - | 0 | Mouse | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 619 | 12 | 4 | 4 | 4.0 | CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)/C=C/c1ccccc1)C(=O)N1CC(=O)N[C@@H](Cc2ccccc2)C1 | 10.1016/S0960-894X(01)80253-5 | |||
10414170 | 177397 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 515 | 5 | 2 | 4 | 4.3 | O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N2CCCC2)C1=O | 10.1021/jm00121a004 | |||
CHEMBL445095 | 177397 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 515 | 5 | 2 | 4 | 4.3 | O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N2CCCC2)C1=O | 10.1021/jm00121a004 | |||
15104602 | 16224 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 486 | 13 | 3 | 2 | 6.2 | CCCCCN(CCCCC)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1cc2ccccc2[nH]1 | 10.1021/jm00116a002 | |||
CHEMBL111808 | 16224 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 486 | 13 | 3 | 2 | 6.2 | CCCCCN(CCCCC)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1cc2ccccc2[nH]1 | 10.1021/jm00116a002 | |||
44366583 | 128073 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 420 | 4 | 1 | 5 | 4.9 | CC(C)(C)OC(=O)n1cc(CC2CN(Cc3ccccc3)CCC2O)c2ccccc21 | 10.1016/0960-894X(94)80030-8 | |||
CHEMBL358016 | 128073 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 420 | 4 | 1 | 5 | 4.9 | CC(C)(C)OC(=O)n1cc(CC2CN(Cc3ccccc3)CCC2O)c2ccccc21 | 10.1016/0960-894X(94)80030-8 | |||
73354294 | 113745 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 636 | 11 | 6 | 5 | 4.2 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CP(=O)(O)O)c1ccccc1 | 10.1021/jm00092a007 | |||
CHEMBL315055 | 113745 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 636 | 11 | 6 | 5 | 4.2 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CP(=O)(O)O)c1ccccc1 | 10.1021/jm00092a007 | |||
15104610 | 16458 | 0 | None | - | 0 | Guinea pig | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 513 | 13 | 3 | 3 | 6.6 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccc2cc(O)ccc2c1 | 10.1021/jm00116a002 | |||
CHEMBL113041 | 16458 | 0 | None | - | 0 | Guinea pig | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 513 | 13 | 3 | 3 | 6.6 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccc2cc(O)ccc2c1 | 10.1021/jm00116a002 | |||
44280388 | 123647 | 0 | None | - | 1 | Mouse | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 759 | 15 | 4 | 8 | 5.0 | Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
CHEMBL33819 | 123647 | 0 | None | - | 1 | Mouse | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 759 | 15 | 4 | 8 | 5.0 | Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
44334330 | 11801 | 0 | None | - | 0 | Guinea pig | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 435 | 7 | 2 | 3 | 4.7 | Cc1cccc(NC(=O)N[C@@H](CC(C)C)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
CHEMBL105153 | 11801 | 0 | None | - | 0 | Guinea pig | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 435 | 7 | 2 | 3 | 4.7 | Cc1cccc(NC(=O)N[C@@H](CC(C)C)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
44381319 | 127503 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 495 | 11 | 4 | 5 | 3.6 | N#C[C@H](N[C@@H](Cc1ccccc1)C(N)=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1 | 10.1016/S0960-894X(97)00107-8 | |||
CHEMBL354817 | 127503 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 495 | 11 | 4 | 5 | 3.6 | N#C[C@H](N[C@@H](Cc1ccccc1)C(N)=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1 | 10.1016/S0960-894X(97)00107-8 | |||
10626596 | 119558 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 555 | 7 | 1 | 4 | 5.6 | O=C1C(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc2N1CC(=O)N(c1ccccc1)C1CC1 | 10.1021/jm970265x | |||
CHEMBL330566 | 119558 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 555 | 7 | 1 | 4 | 5.6 | O=C1C(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc2N1CC(=O)N(c1ccccc1)C1CC1 | 10.1021/jm970265x | |||
44327457 | 114115 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 571 | 11 | 3 | 4 | 5.6 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCC(=O)O)CCc1ccccc1 | 10.1016/S0960-894X(01)80769-1 | |||
CHEMBL317577 | 114115 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 571 | 11 | 3 | 4 | 5.6 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCC(=O)O)CCc1ccccc1 | 10.1016/S0960-894X(01)80769-1 | |||
CHEMBL262767 | 217327 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | None | None | None | Cc1ccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 | 10.1021/jm00113a023 | |||||
CHEMBL262767 | 217327 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | None | None | None | Cc1ccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 | 10.1021/jm960509y | |||||
CHEMBL262767 | 217327 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | None | None | None | Cc1ccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 | 10.1021/jm00173a006 | |||||
44333311 | 11031 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 476 | 6 | 2 | 5 | 3.5 | CCCc1cccc(NC(=O)NC2N=C(N3CCN(C)CC3)c3ccccc3N(CCC)C2=O)c1 | 10.1016/0960-894X(95)00530-0 | |||
CHEMBL100502 | 11031 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 476 | 6 | 2 | 5 | 3.5 | CCCc1cccc(NC(=O)NC2N=C(N3CCN(C)CC3)c3ccccc3N(CCC)C2=O)c1 | 10.1016/0960-894X(95)00530-0 | |||
44303481 | 107475 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 524 | 9 | 3 | 6 | 4.3 | CC(=O)Nc1nc(CC(C)(NC(=O)OC2C3CC4CC(C3)CC2C4)C(=O)NCCc2ccccc2)cs1 | 10.1016/S0960-894X(97)00356-9 | |||
CHEMBL292422 | 107475 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 524 | 9 | 3 | 6 | 4.3 | CC(=O)Nc1nc(CC(C)(NC(=O)OC2C3CC4CC(C3)CC2C4)C(=O)NCCc2ccccc2)cs1 | 10.1016/S0960-894X(97)00356-9 | |||
10789887 | 214206 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 454 | 6 | 3 | 7 | 4.2 | CC(C)Oc1cccc(-n2c(NNC(=O)Nc3cccc(C#N)c3)nc3ccccc3c2=O)c1 | 10.1021/jm970373j | |||
CHEMBL9405 | 214206 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 454 | 6 | 3 | 7 | 4.2 | CC(C)Oc1cccc(-n2c(NNC(=O)Nc3cccc(C#N)c3)nc3ccccc3c2=O)c1 | 10.1021/jm970373j | |||
45482492 | 204763 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 495 | 7 | 4 | 3 | 4.9 | O=C(Nc1ccccc1C(=O)NC(Cc1ccccc1)C(=O)O)c1cc2cccc(C(F)(F)F)c2[nH]1 | 10.1016/j.bmc.2009.05.067 | |||
CHEMBL573560 | 204763 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 495 | 7 | 4 | 3 | 4.9 | O=C(Nc1ccccc1C(=O)NC(Cc1ccccc1)C(=O)O)c1cc2cccc(C(F)(F)F)c2[nH]1 | 10.1016/j.bmc.2009.05.067 | |||
10370499 | 43726 | 0 | None | - | 1 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CC(=O)O)Cc1ccccc1 | 10.1016/S0960-894X(00)80685-X | |||
CHEMBL145133 | 43726 | 0 | None | - | 1 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CC(=O)O)Cc1ccccc1 | 10.1016/S0960-894X(00)80685-X | |||
10370499 | 43726 | 0 | None | - | 1 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CC(=O)O)Cc1ccccc1 | 10.1016/s0960-894x(98)00677-5 | |||
CHEMBL145133 | 43726 | 0 | None | - | 1 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CC(=O)O)Cc1ccccc1 | 10.1016/s0960-894x(98)00677-5 | |||
10370499 | 92765 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](CC(=O)O)Cc1ccccc1 | 10.1021/jm00057a005 | |||
CHEMBL2304064 | 92765 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](CC(=O)O)Cc1ccccc1 | 10.1021/jm00057a005 | |||
10769315 | 23613 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 566 | 8 | 4 | 5 | 3.5 | O=C(N[C@H]1C[C@@H]2c3[nH]c4ccccc4c3C[C@@H](C(=O)N[C@H](Cc3ccccc3)C(=O)O)N2C1=O)OCc1ccccc1 | 10.1021/jm000959x | |||
CHEMBL124798 | 23613 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 566 | 8 | 4 | 5 | 3.5 | O=C(N[C@H]1C[C@@H]2c3[nH]c4ccccc4c3C[C@@H](C(=O)N[C@H](Cc3ccccc3)C(=O)O)N2C1=O)OCc1ccccc1 | 10.1021/jm000959x | |||
11621814 | 148017 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 717 | 10 | 6 | 6 | 3.7 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1C[C@H]2c3[nH]c4ccccc4c3C[C@H](C(=O)N[C@@H](Cc3ccccc3)C(N)=O)N2C1=O | 10.1021/jm050689o | |||
CHEMBL382953 | 148017 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 717 | 10 | 6 | 6 | 3.7 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1C[C@H]2c3[nH]c4ccccc4c3C[C@H](C(=O)N[C@@H](Cc3ccccc3)C(N)=O)N2C1=O | 10.1021/jm050689o | |||
10507109 | 116004 | 0 | None | -1 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 561 | 7 | 2 | 4 | 5.3 | CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1021/jm960205b | |||
CHEMBL321761 | 116004 | 0 | None | -1 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 561 | 7 | 2 | 4 | 5.3 | CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1021/jm960205b | |||
44370473 | 57636 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 435 | 15 | 3 | 4 | 4.3 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)Nc1cccc(OC)c1 | 10.1021/jm00164a020 | |||
CHEMBL157722 | 57636 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 435 | 15 | 3 | 4 | 4.3 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)Nc1cccc(OC)c1 | 10.1021/jm00164a020 | |||
44280213 | 108395 | 0 | None | - | 1 | Mouse | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 685 | 12 | 5 | 9 | 3.7 | Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCSCc4csc(N=C(N)N)n4)c3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
CHEMBL29888 | 108395 | 0 | None | - | 1 | Mouse | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 685 | 12 | 5 | 9 | 3.7 | Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCSCc4csc(N=C(N)N)n4)c3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
70697518 | 84581 | 0 | None | - | 0 | Guinea pig | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 367 | 3 | 2 | 3 | 4.4 | O=C1Nc2ccccc2C(c2ccccc2)=NC1C[C@@H]1CNc2ccccc21 | 10.1021/jm00390a019 | |||
CHEMBL2092748 | 84581 | 0 | None | - | 0 | Guinea pig | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 367 | 3 | 2 | 3 | 4.4 | O=C1Nc2ccccc2C(c2ccccc2)=NC1C[C@@H]1CNc2ccccc21 | 10.1021/jm00390a019 | |||
10649606 | 56390 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 519 | 6 | 3 | 4 | 4.5 | O=C(CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)Nc1ccccc1 | 10.1016/j.bmcl.2015.03.051 | |||
CHEMBL156605 | 56390 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 519 | 6 | 3 | 4 | 4.5 | O=C(CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)Nc1ccccc1 | 10.1016/j.bmcl.2015.03.051 | |||
44283087 | 127602 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 500 | 8 | 2 | 4 | 5.8 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)OCCc1ccccc1 | 10.1021/jm00086a017 | |||
CHEMBL35580 | 127602 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 500 | 8 | 2 | 4 | 5.8 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)OCCc1ccccc1 | 10.1021/jm00086a017 | |||
45482494 | 204764 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 445 | 7 | 4 | 3 | 4.0 | O=C(Nc1ccccc1C(=O)N[C@H](Cc1ccccc1)C(=O)O)c1cc2cccc(F)c2[nH]1 | 10.1016/j.bmc.2009.05.067 | |||
CHEMBL573561 | 204764 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 445 | 7 | 4 | 3 | 4.0 | O=C(Nc1ccccc1C(=O)N[C@H](Cc1ccccc1)C(=O)O)c1cc2cccc(F)c2[nH]1 | 10.1016/j.bmc.2009.05.067 | |||
54582288 | 68644 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 515 | 5 | 0 | 6 | 5.6 | COc1ccc(-c2cnc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccccc2C)cc1 | 10.1016/j.bmcl.2011.03.069 | |||
CHEMBL1773893 | 68644 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 515 | 5 | 0 | 6 | 5.6 | COc1ccc(-c2cnc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccccc2C)cc1 | 10.1016/j.bmcl.2011.03.069 | |||
90663977 | 113577 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 823 | 21 | 8 | 8 | 3.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
CHEMBL3144539 | 113577 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 823 | 21 | 8 | 8 | 3.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
44386117 | 138129 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 541 | 9 | 4 | 4 | 5.3 | O=C(O)C[C@H](Cc1ccccc1)NC(=O)/C(=C/c1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 | 10.1016/S0960-894X(00)80273-5 | |||
CHEMBL368803 | 138129 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 541 | 9 | 4 | 4 | 5.3 | O=C(O)C[C@H](Cc1ccccc1)NC(=O)/C(=C/c1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 | 10.1016/S0960-894X(00)80273-5 | |||
44458120 | 105737 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 377 | 5 | 3 | 3 | 2.0 | O=C(N[C@@H]1C(=O)N(Cc2ccccc2)C[C@@H]1C(=O)O)c1cc2ccccc2[nH]1 | 10.1016/S0960-894X(00)80224-3 | |||
CHEMBL279730 | 105737 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 377 | 5 | 3 | 3 | 2.0 | O=C(N[C@@H]1C(=O)N(Cc2ccccc2)C[C@@H]1C(=O)O)c1cc2ccccc2[nH]1 | 10.1016/S0960-894X(00)80224-3 | |||
44366587 | 50466 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 554 | 10 | 0 | 8 | 7.2 | CCOP(=O)(OCC)OC1=CCN(Cc2ccccc2)CC1Cc1cn(C(=O)OC(C)(C)C)c2ccccc12 | 10.1016/0960-894X(94)80030-8 | |||
CHEMBL151022 | 50466 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 554 | 10 | 0 | 8 | 7.2 | CCOP(=O)(OCC)OC1=CCN(Cc2ccccc2)CC1Cc1cn(C(=O)OC(C)(C)C)c2ccccc12 | 10.1016/0960-894X(94)80030-8 | |||
CHEMBL441840 | 220676 | 0 | None | - | 0 | Mouse | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N1CC(=O)N[C@@H](Cc2ccccc2)C1 | 10.1016/S0960-894X(01)80253-5 | |||||
14208246 | 211461 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 407 | 3 | 2 | 3 | 4.0 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccccc1Cl | 10.1021/jm00120a002 | |||
CHEMBL73892 | 211461 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 407 | 3 | 2 | 3 | 4.0 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccccc1Cl | 10.1021/jm00120a002 | |||
15637194 | 32711 | 0 | None | - | 0 | Rat | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 308 | 2 | 2 | 3 | 1.5 | CN1C(=O)C(NC(N)=O)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL135405 | 32711 | 0 | None | - | 0 | Rat | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 308 | 2 | 2 | 3 | 1.5 | CN1C(=O)C(NC(N)=O)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
44592484 | 194891 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 337 | 5 | 4 | 3 | 2.2 | O=C(O)CNC(=O)c1ccccc1NC(=O)c1cc2ccccc2[nH]1 | 10.1016/j.bmc.2009.02.012 | |||
CHEMBL498273 | 194891 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 337 | 5 | 4 | 3 | 2.2 | O=C(O)CNC(=O)c1ccccc1NC(=O)c1cc2ccccc2[nH]1 | 10.1016/j.bmc.2009.02.012 | |||
10553207 | 215051 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 492 | 6 | 2 | 6 | 4.7 | CC(C)Oc1cccc(-n2c(NNC(=O)c3ccc(Br)cc3)nc3ccccc3c2=O)c1 | 10.1021/jm970373j | |||
CHEMBL9888 | 215051 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 492 | 6 | 2 | 6 | 4.7 | CC(C)Oc1cccc(-n2c(NNC(=O)c3ccc(Br)cc3)nc3ccccc3c2=O)c1 | 10.1021/jm970373j | |||
23757281 | 16623 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 539 | 8 | 2 | 5 | 5.5 | CCN(CC)c1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1021/jm960669+ | |||
CHEMBL114072 | 16623 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 539 | 8 | 2 | 5 | 5.5 | CCN(CC)c1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1021/jm960669+ | |||
10389643 | 125799 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 462 | 5 | 3 | 4 | 3.8 | O=C(O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL342614 | 125799 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 462 | 5 | 3 | 4 | 3.8 | O=C(O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
9984739 | 121592 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 538 | 5 | 3 | 3 | 6.2 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2C1CCCCC1 | 10.1021/jm00048a015 | |||
CHEMBL334100 | 121592 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 538 | 5 | 3 | 3 | 6.2 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2C1CCCCC1 | 10.1021/jm00048a015 | |||
44280180 | 109410 | 0 | None | - | 0 | Mouse | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 655 | 11 | 5 | 8 | 3.6 | CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCSCc3csc(N=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00248-X | |||
CHEMBL30430 | 109410 | 0 | None | - | 0 | Mouse | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 655 | 11 | 5 | 8 | 3.6 | CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCSCc3csc(N=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00248-X | |||
44329304 | 114895 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 526 | 7 | 3 | 3 | 5.5 | Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)NC(C)C)C2=O)c1 | 10.1016/S0960-894X(01)80832-5 | |||
CHEMBL319569 | 114895 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 526 | 7 | 3 | 3 | 5.5 | Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)NC(C)C)C2=O)c1 | 10.1016/S0960-894X(01)80832-5 | |||
44382749 | 66483 | 0 | None | - | 0 | Mouse | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 532 | 11 | 4 | 4 | 3.0 | CC(C)C[C@H](NC(=O)CCc1c[nH]c2ccccc12)C(=O)N1C[C@H](Cc2ccccc2)NC(=O)[C@@H]1CC(=O)O | 10.1016/S0960-894X(01)80253-5 | |||
CHEMBL172354 | 66483 | 0 | None | - | 0 | Mouse | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 532 | 11 | 4 | 4 | 3.0 | CC(C)C[C@H](NC(=O)CCc1c[nH]c2ccccc12)C(=O)N1C[C@H](Cc2ccccc2)NC(=O)[C@@H]1CC(=O)O | 10.1016/S0960-894X(01)80253-5 | |||
10673307 | 117413 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 511 | 7 | 3 | 5 | 4.2 | CC(C)(C)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(NC=O)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm960669+ | |||
CHEMBL325746 | 117413 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 511 | 7 | 3 | 5 | 4.2 | CC(C)(C)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(NC=O)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm960669+ | |||
14208246 | 211461 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 407 | 3 | 2 | 3 | 4.0 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccccc1Cl | 10.1021/jm00047a021 | |||
CHEMBL73892 | 211461 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 407 | 3 | 2 | 3 | 4.0 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccccc1Cl | 10.1021/jm00047a021 | |||
44327455 | 114122 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 585 | 12 | 3 | 4 | 6.0 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCCC(=O)O)CCc1ccccc1 | 10.1016/S0960-894X(01)80769-1 | |||
CHEMBL317626 | 114122 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 585 | 12 | 3 | 4 | 6.0 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCCC(=O)O)CCc1ccccc1 | 10.1016/S0960-894X(01)80769-1 | |||
15104603 | 16269 | 0 | None | - | 0 | Guinea pig | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 436 | 13 | 3 | 2 | 5.0 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccc[nH]1 | 10.1021/jm00116a002 | |||
CHEMBL112054 | 16269 | 0 | None | - | 0 | Guinea pig | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 436 | 13 | 3 | 2 | 5.0 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccc[nH]1 | 10.1021/jm00116a002 | |||
10412837 | 34396 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 479 | 5 | 3 | 5 | 4.0 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(Cc3n[nH]c(C)n3)C2=O)c1 | 10.1021/jm00078a018 | |||
CHEMBL136975 | 34396 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 479 | 5 | 3 | 5 | 4.0 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(Cc3n[nH]c(C)n3)C2=O)c1 | 10.1021/jm00078a018 | |||
CHEMBL345598 | 218489 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | None | None | None | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)N(C)C(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00031a013 | |||||
44382562 | 65874 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 662 | 13 | 5 | 5 | 5.8 | O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccc(O)cc1)NCCc1ccccc1 | 10.1016/S0960-894X(00)80687-3 | |||
CHEMBL169710 | 65874 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 662 | 13 | 5 | 5 | 5.8 | O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccc(O)cc1)NCCc1ccccc1 | 10.1016/S0960-894X(00)80687-3 | |||
10408567 | 126057 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1ccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc1 | 10.1021/jm00078a018 | |||
CHEMBL343767 | 126057 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1ccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc1 | 10.1021/jm00078a018 | |||
90663991 | 113597 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 868 | 22 | 8 | 10 | 3.2 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc([N+](=O)[O-])cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
CHEMBL3144560 | 113597 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 868 | 22 | 8 | 10 | 3.2 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc([N+](=O)[O-])cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
14991567 | 206579 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 847 | 20 | 8 | 8 | 4.0 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1cccc2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
CHEMBL59404 | 206579 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 847 | 20 | 8 | 8 | 4.0 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1cccc2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
44280117 | 108828 | 0 | None | - | 0 | Mouse | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 672 | 12 | 3 | 6 | 5.9 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
CHEMBL30195 | 108828 | 0 | None | - | 0 | Mouse | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 672 | 12 | 3 | 6 | 5.9 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
14423345 | 211210 | 2 | None | - | 0 | Rat | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 283 | 1 | 1 | 3 | 1.9 | CN1C(=O)C(N)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL72151 | 211210 | 2 | None | - | 0 | Rat | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 283 | 1 | 1 | 3 | 1.9 | CN1C(=O)C(N)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
10768084 | 16791 | 1 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 512 | 6 | 2 | 6 | 4.1 | CN(C)c1cccc(NC(=O)N[C@H]2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1021/jm960669+ | |||
CHEMBL114991 | 16791 | 1 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 512 | 6 | 2 | 6 | 4.1 | CN(C)c1cccc(NC(=O)N[C@H]2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1021/jm960669+ | |||
44408483 | 175708 | 0 | None | -165 | 4 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 1212 | 31 | 12 | 15 | 3.7 | CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@H](Cc1cn(C(=O)OC2C3CC4CC(C3)CC2C4)c2ccccc12)C(=O)O | 10.1021/jm050851n | |||
CHEMBL438739 | 175708 | 0 | None | -165 | 4 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 1212 | 31 | 12 | 15 | 3.7 | CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@H](Cc1cn(C(=O)OC2C3CC4CC(C3)CC2C4)c2ccccc12)C(=O)O | 10.1021/jm050851n | |||
CHEMBL262172 | 217307 | 0 | None | -26302 | 4 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm050921q | |||||
44376112 | 126971 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 452 | 4 | 3 | 6 | 2.8 | CN1C(=O)[C@@H](NC(=O)Nc2ccc(-c3nn[nH]n3)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00032a003 | |||
CHEMBL351854 | 126971 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 452 | 4 | 3 | 6 | 2.8 | CN1C(=O)[C@@H](NC(=O)Nc2ccc(-c3nn[nH]n3)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00032a003 | |||
14208221 | 86323 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 530 | 6 | 2 | 5 | 4.2 | CN1C(=O)C(NC(=O)C(Cc2ccccc2)NC(=O)OC(C)(C)C)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL2114102 | 86323 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 530 | 6 | 2 | 5 | 4.2 | CN1C(=O)C(NC(=O)C(Cc2ccccc2)NC(=O)OC(C)(C)C)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
44354128 | 27066 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 628 | 13 | 5 | 5 | 4.7 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@@H](CNC(=O)CCC(=O)O)Cc1ccccc1 | 10.1021/jm00105a062 | |||
CHEMBL130578 | 27066 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 628 | 13 | 5 | 5 | 4.7 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@@H](CNC(=O)CCC(=O)O)Cc1ccccc1 | 10.1021/jm00105a062 | |||
14802521 | 65858 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 628 | 13 | 5 | 5 | 4.7 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CNC(=O)CCC(=O)O)Cc1ccccc1 | 10.1016/S0960-894X(00)80685-X | |||
CHEMBL169616 | 65858 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 628 | 13 | 5 | 5 | 4.7 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CNC(=O)CCC(=O)O)Cc1ccccc1 | 10.1016/S0960-894X(00)80685-X | |||
10392523 | 214723 | 0 | None | - | 0 | Guinea pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 540 | 6 | 3 | 3 | 5.9 | Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)NC(C)(C)C)C2=O)c1 | 10.1016/S0960-894X(01)80832-5 | |||
CHEMBL96970 | 214723 | 0 | None | - | 0 | Guinea pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 540 | 6 | 3 | 3 | 5.9 | Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)NC(C)(C)C)C2=O)c1 | 10.1016/S0960-894X(01)80832-5 | |||
15104609 | 117316 | 0 | None | - | 0 | Guinea pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 498 | 13 | 2 | 3 | 6.3 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1nccc2ccccc12 | 10.1021/jm00116a002 | |||
CHEMBL325160 | 117316 | 0 | None | - | 0 | Guinea pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 498 | 13 | 2 | 3 | 6.3 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1nccc2ccccc12 | 10.1021/jm00116a002 | |||
19766222 | 123380 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 383 | 5 | 1 | 4 | 3.9 | CC(C)COC(=O)NCC1CN=C(c2ccccc2F)c2ccccc2N1C | 10.1021/jm00163a069 | |||
CHEMBL336690 | 123380 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 383 | 5 | 1 | 4 | 3.9 | CC(C)COC(=O)NCC1CN=C(c2ccccc2F)c2ccccc2N1C | 10.1021/jm00163a069 | |||
14208308 | 74517 | 0 | None | - | 0 | Rat | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 513 | 3 | 1 | 3 | 4.0 | CN1C(=O)[C@H](NC(=O)c2ccccc2I)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL1907845 | 74517 | 0 | None | - | 0 | Rat | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 513 | 3 | 1 | 3 | 4.0 | CN1C(=O)[C@H](NC(=O)c2ccccc2I)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
15167811 | 174670 | 0 | None | - | 0 | Rat | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 417 | 3 | 0 | 3 | 4.3 | CN1C(=O)C(N(C)C(=O)c2ccccc2Cl)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL431185 | 174670 | 0 | None | - | 0 | Rat | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 417 | 3 | 0 | 3 | 4.3 | CN1C(=O)C(N(C)C(=O)c2ccccc2Cl)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
11607292 | 172775 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 717 | 10 | 6 | 6 | 3.7 | CC(C)(C)OC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1C[C@H]2c3[nH]c4ccccc4c3C[C@H](C(=O)N[C@H](Cc3ccccc3)C(N)=O)N2C1=O | 10.1021/jm050689o | |||
CHEMBL425392 | 172775 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 717 | 10 | 6 | 6 | 3.7 | CC(C)(C)OC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1C[C@H]2c3[nH]c4ccccc4c3C[C@H](C(=O)N[C@H](Cc3ccccc3)C(N)=O)N2C1=O | 10.1021/jm050689o | |||
44303526 | 209923 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 708 | 14 | 4 | 6 | 6.3 | O=C(CCC(=O)OCc1ccccc1)N[C@@H](CNC(=O)C(Cc1c[nH]c2ccc(F)cc12)NC(=O)OC1C2CC3CC(C2)CC1C3)c1ccccc1 | 10.1016/S0960-894X(97)00356-9 | |||
CHEMBL64155 | 209923 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 708 | 14 | 4 | 6 | 6.3 | O=C(CCC(=O)OCc1ccccc1)N[C@@H](CNC(=O)C(Cc1c[nH]c2ccc(F)cc12)NC(=O)OC1C2CC3CC(C2)CC1C3)c1ccccc1 | 10.1016/S0960-894X(97)00356-9 | |||
54582313 | 68694 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 572 | 6 | 0 | 7 | 6.0 | COC(=O)c1cc2ccccc2cc1N1CCN(C(=O)c2ncc(-c3ccc(OC)cc3)c(-c3ccc(C)cc3)n2)CC1 | 10.1016/j.bmcl.2011.03.069 | |||
CHEMBL1774039 | 68694 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 572 | 6 | 0 | 7 | 6.0 | COC(=O)c1cc2ccccc2cc1N1CCN(C(=O)c2ncc(-c3ccc(OC)cc3)c(-c3ccc(C)cc3)n2)CC1 | 10.1016/j.bmcl.2011.03.069 | |||
10744359 | 16929 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 513 | 6 | 2 | 6 | 4.5 | CC(C)(C)C(=O)CN1C(=O)C(NC(=O)Nc2cccc([N+](=O)[O-])c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm960669+ | |||
CHEMBL115833 | 16929 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 513 | 6 | 2 | 6 | 4.5 | CC(C)(C)C(=O)CN1C(=O)C(NC(=O)Nc2cccc([N+](=O)[O-])c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm960669+ | |||
15689724 | 113375 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 880 | 20 | 9 | 8 | 4.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1cccc(C(F)(F)F)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||
CHEMBL3142696 | 113375 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 880 | 20 | 9 | 8 | 4.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1cccc(C(F)(F)F)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||
44370497 | 171972 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 453 | 8 | 3 | 3 | 4.6 | O=C(O)CC[C@H](NC(=O)c1cc2ccccc2[nH]1)C(=O)N(C1CCCCC1)C1CCCCC1 | 10.1021/jm00164a020 | |||
CHEMBL422873 | 171972 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 453 | 8 | 3 | 3 | 4.6 | O=C(O)CC[C@H](NC(=O)c1cc2ccccc2[nH]1)C(=O)N(C1CCCCC1)C1CCCCC1 | 10.1021/jm00164a020 | |||
90663256 | 113407 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 854 | 17 | 7 | 8 | 5.3 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N1CSC(C)(C)[C@H]1C(=O)NC(Cc1ccccc1)C(N)=O | 10.1021/jm00100a033 | |||
CHEMBL3143146 | 113407 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 854 | 17 | 7 | 8 | 5.3 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N1CSC(C)(C)[C@H]1C(=O)NC(Cc1ccccc1)C(N)=O | 10.1021/jm00100a033 | |||
155521287 | 177357 | 0 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 478 | 7 | 0 | 6 | 4.8 | CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(c3ccc(F)c(Cl)c3)C(=O)C21 | 10.1021/acs.jmedchem.9b02080 | |||
CHEMBL4450506 | 177357 | 0 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 478 | 7 | 0 | 6 | 4.8 | CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(c3ccc(F)c(Cl)c3)C(=O)C21 | 10.1021/acs.jmedchem.9b02080 | |||
44283081 | 106647 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 500 | 9 | 3 | 3 | 6.4 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(O)CCCc1ccccc1 | 10.1021/jm00086a017 | |||
CHEMBL2112071 | 106647 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 500 | 9 | 3 | 3 | 6.4 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(O)CCCc1ccccc1 | 10.1021/jm00086a017 | |||
CHEMBL285880 | 106647 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 500 | 9 | 3 | 3 | 6.4 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(O)CCCc1ccccc1 | 10.1021/jm00086a017 | |||
14208225 | 74528 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 426 | 3 | 2 | 3 | 3.9 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL1907855 | 74528 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 426 | 3 | 2 | 3 | 3.9 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
14208204 | 211244 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 407 | 3 | 2 | 3 | 4.0 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccc(Cl)cc1 | 10.1021/jm00120a002 | |||
CHEMBL72300 | 211244 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 407 | 3 | 2 | 3 | 4.0 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccc(Cl)cc1 | 10.1021/jm00120a002 | |||
14208204 | 211244 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 407 | 3 | 2 | 3 | 4.0 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccc(Cl)cc1 | 10.1021/jm00047a021 | |||
CHEMBL72300 | 211244 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 407 | 3 | 2 | 3 | 4.0 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccc(Cl)cc1 | 10.1021/jm00047a021 | |||
44376191 | 172104 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 452 | 4 | 3 | 6 | 2.8 | CN1C(=O)[C@H](NC(=O)Nc2ccc(-c3nn[nH]n3)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00032a003 | |||
CHEMBL423472 | 172104 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 452 | 4 | 3 | 6 | 2.8 | CN1C(=O)[C@H](NC(=O)Nc2ccc(-c3nn[nH]n3)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00032a003 | |||
10010890 | 115514 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 874 | 22 | 8 | 8 | 4.3 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00028a015 | |||
CHEMBL320858 | 115514 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 874 | 22 | 8 | 8 | 4.3 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00028a015 | |||
10409534 | 35012 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 414 | 4 | 2 | 4 | 3.7 | COc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00078a018 | |||
CHEMBL137398 | 35012 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 414 | 4 | 2 | 4 | 3.7 | COc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00078a018 | |||
10649606 | 56390 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 519 | 6 | 3 | 4 | 4.5 | O=C(CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)Nc1ccccc1 | 10.1016/j.bmcl.2015.03.051 | |||
CHEMBL156605 | 56390 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 519 | 6 | 3 | 4 | 4.5 | O=C(CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)Nc1ccccc1 | 10.1016/j.bmcl.2015.03.051 | |||
5311205 | 19866 | 1 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 445 | 2 | 2 | 4 | 4.0 | Cc1cccc(NC(=O)N[C@H]2N=C(N3CC4CCC(CC4)C3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00032a002 | |||
CHEMBL1190319 | 19866 | 1 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 445 | 2 | 2 | 4 | 4.0 | Cc1cccc(NC(=O)N[C@H]2N=C(N3CC4CCC(CC4)C3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00032a002 | |||
CHEMBL540596 | 19866 | 1 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 445 | 2 | 2 | 4 | 4.0 | Cc1cccc(NC(=O)N[C@H]2N=C(N3CC4CCC(CC4)C3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00032a002 | |||
54583260 | 68647 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 519 | 5 | 0 | 6 | 5.5 | COc1ccc(-c2cnc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(F)cc2)cc1 | 10.1016/j.bmcl.2011.03.069 | |||
CHEMBL1773896 | 68647 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 519 | 5 | 0 | 6 | 5.5 | COc1ccc(-c2cnc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(F)cc2)cc1 | 10.1016/j.bmcl.2011.03.069 | |||
11039097 | 86321 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 573 | 7 | 3 | 5 | 4.7 | C[C@@H](c1ccccc1)N1C(=O)C[C@H]2[C@H](NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)OC(C)(C)C)CCCN2C1=O | 10.1021/jm010813d | |||
CHEMBL2114084 | 86321 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 573 | 7 | 3 | 5 | 4.7 | C[C@@H](c1ccccc1)N1C(=O)C[C@H]2[C@H](NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)OC(C)(C)C)CCCN2C1=O | 10.1021/jm010813d | |||
24785177 | 196560 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 502 | 5 | 0 | 5 | 6.0 | COc1ccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)cc1 | 10.1016/j.bmcl.2008.06.057 | |||
CHEMBL516113 | 196560 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 502 | 5 | 0 | 5 | 6.0 | COc1ccc(-n2cc(C(=O)N3CCN(c4ccc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)cc1 | 10.1016/j.bmcl.2008.06.057 | |||
CHEMBL3142697 | 217912 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | None | None | None | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccc(Cl)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||||
44373701 | 59265 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 541 | 8 | 4 | 4 | 5.3 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N/C(=C\c1ccccc1)C(=O)O | 10.1016/S0960-894X(01)81250-6 | |||
CHEMBL159138 | 59265 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 541 | 8 | 4 | 4 | 5.3 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N/C(=C\c1ccccc1)C(=O)O | 10.1016/S0960-894X(01)81250-6 | |||
9978327 | 85591 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 400 | 3 | 3 | 4 | 3.4 | CN1C(=O)[C@H](NC(=O)Nc2cccc(O)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL2112753 | 85591 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 400 | 3 | 3 | 4 | 3.4 | CN1C(=O)[C@H](NC(=O)Nc2cccc(O)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
11765552 | 120407 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 742 | 17 | 7 | 6 | 5.8 | Cc1ccccc1NC(=O)NCCCC[C@@H](CNC(=O)CCC(=O)O)NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 | 10.1021/jm00017a022 | |||
CHEMBL332263 | 120407 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 742 | 17 | 7 | 6 | 5.8 | Cc1ccccc1NC(=O)NCCCC[C@@H](CNC(=O)CCC(=O)O)NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 | 10.1021/jm00017a022 | |||
44300888 | 107568 | 0 | None | - | 0 | Guinea pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 580 | 6 | 4 | 6 | 4.5 | Cc1ccc([C@H]2C[C@@H](NC(=O)Nc3cccc(-c4nn[nH]n4)c3)C(=O)N(CC(=O)NC(C)(C)C)c3cc(C)ccc32)cc1 | 10.1016/0960-894X(95)00327-P | |||
CHEMBL293107 | 107568 | 0 | None | - | 0 | Guinea pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 580 | 6 | 4 | 6 | 4.5 | Cc1ccc([C@H]2C[C@@H](NC(=O)Nc3cccc(-c4nn[nH]n4)c3)C(=O)N(CC(=O)NC(C)(C)C)c3cc(C)ccc32)cc1 | 10.1016/0960-894X(95)00327-P | |||
44348808 | 24707 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 451 | 7 | 3 | 4 | 3.9 | O=C(O)CCC(NC(=O)c1ccc2ccccc2c1)C(=O)NN1CCC2(CCCCC2)CC1 | 10.1021/jm00079a003 | |||
CHEMBL125925 | 24707 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 451 | 7 | 3 | 4 | 3.9 | O=C(O)CCC(NC(=O)c1ccc2ccccc2c1)C(=O)NN1CCC2(CCCCC2)CC1 | 10.1021/jm00079a003 | |||
71456207 | 85399 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 655 | 12 | 5 | 7 | 4.9 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CSc1c[nH]nn1)c1ccccc1 | 10.1021/jm00092a007 | |||
CHEMBL2112331 | 85399 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 655 | 12 | 5 | 7 | 4.9 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CSc1c[nH]nn1)c1ccccc1 | 10.1021/jm00092a007 | |||
9853654 | 29561 | 41 | None | - | 2 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 767 | 20 | 8 | 9 | 1.5 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00092a007 | |||
CHEMBL1328 | 29561 | 41 | None | - | 2 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 767 | 20 | 8 | 9 | 1.5 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00092a007 | |||
9853654 | 29561 | 41 | None | - | 2 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 767 | 20 | 8 | 9 | 1.5 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00105a062 | |||
CHEMBL1328 | 29561 | 41 | None | - | 2 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 767 | 20 | 8 | 9 | 1.5 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00105a062 | |||
15104627 | 117255 | 0 | None | - | 0 | Guinea pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 462 | 7 | 2 | 3 | 4.7 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cnc2ccccc2c1 | 10.1021/jm00116a002 | |||
CHEMBL324760 | 117255 | 0 | None | - | 0 | Guinea pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 462 | 7 | 2 | 3 | 4.7 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cnc2ccccc2c1 | 10.1021/jm00116a002 | |||
9853654 | 29561 | 41 | None | - | 2 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 767 | 20 | 8 | 9 | 1.5 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00057a005 | |||
CHEMBL1328 | 29561 | 41 | None | - | 2 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 767 | 20 | 8 | 9 | 1.5 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00057a005 | |||
44360121 | 123523 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 417 | 5 | 2 | 4 | 3.3 | CN1c2ccccc2C(c2ccccc2F)=NCC1CNC(=O)C(O)c1ccccc1 | 10.1021/jm00163a069 | |||
CHEMBL337530 | 123523 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 417 | 5 | 2 | 4 | 3.3 | CN1c2ccccc2C(c2ccccc2F)=NCC1CNC(=O)C(O)c1ccccc1 | 10.1021/jm00163a069 | |||
11742520 | 36399 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 414 | 4 | 2 | 4 | 3.7 | COc1ccccc1NC(=O)NC1N=C(c2ccccc2)c2ccccc2N(C)C1=O | 10.1021/jm00078a018 | |||
CHEMBL138592 | 36399 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 414 | 4 | 2 | 4 | 3.7 | COc1ccccc1NC(=O)NC1N=C(c2ccccc2)c2ccccc2N(C)C1=O | 10.1021/jm00078a018 | |||
10431936 | 100013 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 414 | 4 | 2 | 4 | 3.7 | COc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00078a018 | |||
CHEMBL2448131 | 100013 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 414 | 4 | 2 | 4 | 3.7 | COc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00078a018 | |||
14208198 | 111155 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 537 | 6 | 4 | 5 | 4.5 | CC(C)(C)OC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NC1N=C(c2ccccc2)c2ccccc2NC1=O | 10.1021/jm00120a002 | |||
CHEMBL310246 | 111155 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 537 | 6 | 4 | 5 | 4.5 | CC(C)(C)OC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NC1N=C(c2ccccc2)c2ccccc2NC1=O | 10.1021/jm00120a002 | |||
44349410 | 23549 | 0 | None | - | 0 | Rat | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 394 | 7 | 3 | 3 | 3.5 | O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NC1CCCCCCC1 | 10.1021/jm00079a003 | |||
CHEMBL124459 | 23549 | 0 | None | - | 0 | Rat | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 394 | 7 | 3 | 3 | 3.5 | O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NC1CCCCCCC1 | 10.1021/jm00079a003 | |||
15556550 | 74497 | 0 | None | - | 0 | Guinea pig | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 326 | 3 | 1 | 2 | 4.5 | CC(C)C[C@H]1N=C(c2ccccc2)c2cc(Cl)ccc2NC1=O | 10.1021/jm00390a019 | |||
CHEMBL1907736 | 74497 | 0 | None | - | 0 | Guinea pig | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 326 | 3 | 1 | 2 | 4.5 | CC(C)C[C@H]1N=C(c2ccccc2)c2cc(Cl)ccc2NC1=O | 10.1021/jm00390a019 | |||
11571172 | 147362 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 695 | 10 | 2 | 6 | 6.6 | COc1ccc(N(C(=O)CN2C(=O)[C@H](NC(=O)Nc3cccc(C(=O)c4ccccc4)c3)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm049072h | |||
CHEMBL381347 | 147362 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 695 | 10 | 2 | 6 | 6.6 | COc1ccc(N(C(=O)CN2C(=O)[C@H](NC(=O)Nc3cccc(C(=O)c4ccccc4)c3)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm049072h | |||
19018661 | 35256 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 442 | 5 | 3 | 4 | 3.3 | CN1C(=O)C(NC(=O)Nc2cccc(CC(=O)O)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL137567 | 35256 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 442 | 5 | 3 | 4 | 3.3 | CN1C(=O)C(NC(=O)Nc2cccc(CC(=O)O)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
10000984 | 123421 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 399 | 3 | 2 | 4 | 3.4 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3cnccc3N(C)C2=O)c1 | 10.1021/jm00078a018 | |||
CHEMBL336972 | 123421 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 399 | 3 | 2 | 4 | 3.4 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3cnccc3N(C)C2=O)c1 | 10.1021/jm00078a018 | |||
46235271 | 80423 | 2 | None | 2 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 649 | 7 | 1 | 6 | 6.7 | Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1021/acs.jmedchem.5b01110 | |||
CHEMBL2017835 | 80423 | 2 | None | 2 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 649 | 7 | 1 | 6 | 6.7 | Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1021/acs.jmedchem.5b01110 | |||
10392523 | 214723 | 0 | None | - | 0 | Guinea pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 540 | 6 | 3 | 3 | 5.9 | Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)NC(C)(C)C)C2=O)c1 | 10.1016/S0960-894X(01)80832-5 | |||
CHEMBL96970 | 214723 | 0 | None | - | 0 | Guinea pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 540 | 6 | 3 | 3 | 5.9 | Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)NC(C)(C)C)C2=O)c1 | 10.1016/S0960-894X(01)80832-5 | |||
44280996 | 106520 | 0 | None | - | 1 | Mouse | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 745 | 14 | 4 | 8 | 5.4 | CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00249-1 | |||
CHEMBL284976 | 106520 | 0 | None | - | 1 | Mouse | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 745 | 14 | 4 | 8 | 5.4 | CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00249-1 | |||
15614737 | 82710 | 0 | None | - | 0 | Guinea pig | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 410 | 3 | 1 | 2 | 5.9 | O=C1Nc2ccc(Cl)cc2C(c2ccccc2)=NC1Cc1ccc2ccccc2c1 | 10.1021/jm00390a019 | |||
CHEMBL20514 | 82710 | 0 | None | - | 0 | Guinea pig | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 410 | 3 | 1 | 2 | 5.9 | O=C1Nc2ccc(Cl)cc2C(c2ccccc2)=NC1Cc1ccc2ccccc2c1 | 10.1021/jm00390a019 | |||
44303299 | 208030 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 598 | 11 | 4 | 6 | 5.5 | CC(Cc1ccc(Oc2ccccc2)cc1)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CO)[C@H](O)c1ccccc1 | 10.1016/S0960-894X(97)00356-9 | |||
CHEMBL60386 | 208030 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 598 | 11 | 4 | 6 | 5.5 | CC(Cc1ccc(Oc2ccccc2)cc1)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CO)[C@H](O)c1ccccc1 | 10.1016/S0960-894X(97)00356-9 | |||
52949124 | 7663 | 4 | None | -2 | 2 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
9055 | 7663 | 4 | None | -2 | 2 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
CHEMBL1269258 | 7663 | 4 | None | -2 | 2 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
DB12694 | 7663 | 4 | None | -2 | 2 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
14208298 | 211412 | 1 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 465 | 3 | 1 | 3 | 4.2 | CN1C(=O)C(NC(=O)c2ccccc2Br)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00047a021 | |||
CHEMBL73511 | 211412 | 1 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 465 | 3 | 1 | 3 | 4.2 | CN1C(=O)C(NC(=O)c2ccccc2Br)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00047a021 | |||
44210425 | 172073 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 439 | 5 | 2 | 5 | 3.5 | COc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)OC(C)(C)C)C2=O)c1 | 10.1016/S0960-894X(00)80683-6 | |||
CHEMBL423278 | 172073 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 439 | 5 | 2 | 5 | 3.5 | COc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)OC(C)(C)C)C2=O)c1 | 10.1016/S0960-894X(00)80683-6 | |||
9960703 | 174817 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 621 | 6 | 3 | 7 | 4.0 | O=C(Nc1cccc(-c2nn[nH]n2)c1)NC1N=C(c2ccccc2F)c2ccccc2N(CC(=O)N2CC3CCC(CC3)C2)C1=O | 10.1016/s0960-894x(98)00237-6 | |||
CHEMBL432266 | 174817 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 621 | 6 | 3 | 7 | 4.0 | O=C(Nc1cccc(-c2nn[nH]n2)c1)NC1N=C(c2ccccc2F)c2ccccc2N(CC(=O)N2CC3CCC(CC3)C2)C1=O | 10.1016/s0960-894x(98)00237-6 | |||
44287087 | 107240 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 796 | 19 | 7 | 7 | 4.5 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N(C)CCC(=O)NC(Cc1ccccc1)C(N)=O | 10.1021/jm00037a005 | |||
CHEMBL290719 | 107240 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 796 | 19 | 7 | 7 | 4.5 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N(C)CCC(=O)NC(Cc1ccccc1)C(N)=O | 10.1021/jm00037a005 | |||
44458113 | 174954 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 392 | 4 | 2 | 3 | 2.8 | O=C(N[C@@H]1C(=O)N(c2ccccc2F)C[C@@H]1C(=O)O)c1ccc2ccccc2c1 | 10.1016/S0960-894X(00)80224-3 | |||
CHEMBL433222 | 174954 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 392 | 4 | 2 | 3 | 2.8 | O=C(N[C@@H]1C(=O)N(c2ccccc2F)C[C@@H]1C(=O)O)c1ccc2ccccc2c1 | 10.1016/S0960-894X(00)80224-3 | |||
9872735 | 193806 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 567 | 5 | 2 | 4 | 5.1 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3F)c3ccccc3N(CC(=O)N3CC4CCC(CC4)C3)C2=O)c1 | 10.1016/S0960-894X(96)00609-9 | |||
CHEMBL49085 | 193806 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 567 | 5 | 2 | 4 | 5.1 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3F)c3ccccc3N(CC(=O)N3CC4CCC(CC4)C3)C2=O)c1 | 10.1016/S0960-894X(96)00609-9 | |||
44300852 | 108748 | 0 | None | - | 0 | Guinea pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 566 | 6 | 4 | 6 | 4.1 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(-c3nn[nH]n3)c1)C[C@@H]2c1ccccc1 | 10.1016/0960-894X(95)00327-P | |||
CHEMBL301418 | 108748 | 0 | None | - | 0 | Guinea pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 566 | 6 | 4 | 6 | 4.1 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(-c3nn[nH]n3)c1)C[C@@H]2c1ccccc1 | 10.1016/0960-894X(95)00327-P | |||
71458004 | 85403 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 670 | 12 | 5 | 8 | 4.7 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCn1nn[nH]c1=S)c1ccccc1 | 10.1021/jm00092a007 | |||
CHEMBL2112335 | 85403 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 670 | 12 | 5 | 8 | 4.7 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCn1nn[nH]c1=S)c1ccccc1 | 10.1021/jm00092a007 | |||
10323690 | 107274 | 0 | None | - | 2 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 499 | 8 | 3 | 3 | 5.4 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccc1 | 10.1021/jm00105a062 | |||
CHEMBL2114401 | 107274 | 0 | None | - | 2 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 499 | 8 | 3 | 3 | 5.4 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccc1 | 10.1021/jm00105a062 | |||
CHEMBL291033 | 107274 | 0 | None | - | 2 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 499 | 8 | 3 | 3 | 5.4 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccc1 | 10.1021/jm00105a062 | |||
14208299 | 74516 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 465 | 3 | 1 | 3 | 4.2 | CN1C(=O)[C@@H](NC(=O)c2ccccc2Br)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL1907844 | 74516 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 465 | 3 | 1 | 3 | 4.2 | CN1C(=O)[C@@H](NC(=O)c2ccccc2Br)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
10416987 | 18981 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 539 | 5 | 2 | 4 | 3.2 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)N3CC[N+](C)(C)CC3)C2=O)c1 | 10.1021/jm00078a018 | |||
CHEMBL1184312 | 18981 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 539 | 5 | 2 | 4 | 3.2 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)N3CC[N+](C)(C)CC3)C2=O)c1 | 10.1021/jm00078a018 | |||
CHEMBL343949 | 18981 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 539 | 5 | 2 | 4 | 3.2 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)N3CC[N+](C)(C)CC3)C2=O)c1 | 10.1021/jm00078a018 | |||
11607291 | 177797 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 717 | 10 | 6 | 6 | 3.7 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1C[C@@H]2c3[nH]c4ccccc4c3C[C@@H](C(=O)N[C@@H](Cc3ccccc3)C(N)=O)N2C1=O | 10.1021/jm050689o | |||
CHEMBL445662 | 177797 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 717 | 10 | 6 | 6 | 3.7 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1C[C@@H]2c3[nH]c4ccccc4c3C[C@@H](C(=O)N[C@@H](Cc3ccccc3)C(N)=O)N2C1=O | 10.1021/jm050689o | |||
44368594 | 127829 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 447 | 8 | 3 | 3 | 4.9 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1CCCCC1)C(=O)NCCc1ccccc1 | 10.1021/jm00057a005 | |||
CHEMBL356810 | 127829 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 447 | 8 | 3 | 3 | 4.9 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1CCCCC1)C(=O)NCCc1ccccc1 | 10.1021/jm00057a005 | |||
44349073 | 23329 | 0 | None | - | 0 | Rat | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 395 | 7 | 3 | 4 | 2.5 | CC1(C)CCN(NC(=O)C(CCC(=O)O)NC(=O)c2cccc(Cl)c2)CC1 | 10.1021/jm00079a003 | |||
CHEMBL123785 | 23329 | 0 | None | - | 0 | Rat | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 395 | 7 | 3 | 4 | 2.5 | CC1(C)CCN(NC(=O)C(CCC(=O)O)NC(=O)c2cccc(Cl)c2)CC1 | 10.1021/jm00079a003 | |||
11124446 | 85211 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 545 | 6 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)N(c3ccccc3)C(=O)C[C@H]12 | 10.1021/jm010813d | |||
CHEMBL2111552 | 85211 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 545 | 6 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)N(c3ccccc3)C(=O)C[C@H]12 | 10.1021/jm010813d | |||
14519981 | 16832 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 441 | 14 | 2 | 4 | 4.4 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1ccc2ccccc2n1 | 10.1021/jm00124a003 | |||
CHEMBL115269 | 16832 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 441 | 14 | 2 | 4 | 4.4 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1ccc2ccccc2n1 | 10.1021/jm00124a003 | |||
14519981 | 16832 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 441 | 14 | 2 | 4 | 4.4 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1ccc2ccccc2n1 | 10.1021/jm00116a002 | |||
CHEMBL115269 | 16832 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 441 | 14 | 2 | 4 | 4.4 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1ccc2ccccc2n1 | 10.1021/jm00116a002 | |||
44370694 | 54784 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 488 | 15 | 2 | 4 | 4.8 | CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)N1CCCC1)NC(=O)Nc1cccc(OC)c1 | 10.1021/jm00164a020 | |||
CHEMBL155017 | 54784 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 488 | 15 | 2 | 4 | 4.8 | CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)N1CCCC1)NC(=O)Nc1cccc(OC)c1 | 10.1021/jm00164a020 | |||
10348659 | 8585 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 604 | 8 | 2 | 5 | 5.4 | O=C(NC1C(=O)N(c2ccccc2)c2c(N(C1=O)CC(=O)N(c1ccc(cc1)N(C)C)C(C)C)cccc2)Nc1ccccc1 | 10.1021/jm950626d | |||
866 | 8585 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 604 | 8 | 2 | 5 | 5.4 | O=C(NC1C(=O)N(c2ccccc2)c2c(N(C1=O)CC(=O)N(c1ccc(cc1)N(C)C)C(C)C)cccc2)Nc1ccccc1 | 10.1021/jm950626d | |||
CHEMBL1184355 | 8585 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 604 | 8 | 2 | 5 | 5.4 | O=C(NC1C(=O)N(c2ccccc2)c2c(N(C1=O)CC(=O)N(c1ccc(cc1)N(C)C)C(C)C)cccc2)Nc1ccccc1 | 10.1021/jm950626d | |||
44306887 | 108838 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 816 | 18 | 9 | 7 | 3.4 | CC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NC(Cc1cccc(NC(=O)Nc2ccccc2C)c1)C(=O)N[C@H](CC(=O)O)C(=O)N[C@@H](Cc1ccc(C)cc1)C(N)=O | 10.1021/jm00001a027 | |||
CHEMBL302027 | 108838 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 816 | 18 | 9 | 7 | 3.4 | CC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NC(Cc1cccc(NC(=O)Nc2ccccc2C)c1)C(=O)N[C@H](CC(=O)O)C(=O)N[C@@H](Cc1ccc(C)cc1)C(N)=O | 10.1021/jm00001a027 | |||
CHEMBL355778 | 218519 | 0 | None | - | 0 | Mouse | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N1C[C@H](CCc2ccccc2)NC(=O)[C@@H]1CC(=O)O | 10.1016/S0960-894X(01)80253-5 | |||||
19910130 | 126569 | 0 | None | - | 0 | Guinea pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 439 | 14 | 3 | 3 | 4.9 | CCCCCN(CCCCC)C(=O)C(CCC(=O)O)NC(=O)Nc1ccc(Cl)cc1 | 10.1021/jm00164a020 | |||
CHEMBL348168 | 126569 | 0 | None | - | 0 | Guinea pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 439 | 14 | 3 | 3 | 4.9 | CCCCCN(CCCCC)C(=O)C(CCC(=O)O)NC(=O)Nc1ccc(Cl)cc1 | 10.1021/jm00164a020 | |||
44578398 | 188563 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 502 | 5 | 0 | 5 | 6.0 | COc1cccc(-n2cc(C(=O)N3CCN(c4cccc5ccccc45)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
CHEMBL477784 | 188563 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 502 | 5 | 0 | 5 | 6.0 | COc1cccc(-n2cc(C(=O)N3CCN(c4cccc5ccccc45)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
CHEMBL172177 | 215630 | 0 | None | - | 0 | Mouse | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N1C[C@@H](Cc2ccccc2)NC(=O)[C@H]1CC(=O)O | 10.1016/S0960-894X(01)80253-5 | |||||
44349064 | 23292 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 435 | 7 | 3 | 4 | 3.4 | O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NN1CCC2(CCCCC2)CC1 | 10.1021/jm00079a003 | |||
CHEMBL123684 | 23292 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 435 | 7 | 3 | 4 | 3.4 | O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NN1CCC2(CCCCC2)CC1 | 10.1021/jm00079a003 | |||
15167820 | 74488 | 0 | None | - | 0 | Guinea pig | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 393 | 3 | 0 | 3 | 4.6 | CN1C(=O)[C@@H](Cc2cn(C)c3ccccc23)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00390a019 | |||
CHEMBL1907724 | 74488 | 0 | None | - | 0 | Guinea pig | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 393 | 3 | 0 | 3 | 4.6 | CN1C(=O)[C@@H](Cc2cn(C)c3ccccc23)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00390a019 | |||
44327699 | 214261 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 641 | 15 | 2 | 5 | 7.2 | COC(=O)CCCCCCN(CCc1ccccc1)C(=O)[C@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1016/S0960-894X(01)80769-1 | |||
CHEMBL94352 | 214261 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 641 | 15 | 2 | 5 | 7.2 | COC(=O)CCCCCCN(CCc1ccccc1)C(=O)[C@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1016/S0960-894X(01)80769-1 | |||
52949124 | 7663 | 4 | None | -2 | 2 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
9055 | 7663 | 4 | None | -2 | 2 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
CHEMBL1269258 | 7663 | 4 | None | -2 | 2 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
DB12694 | 7663 | 4 | None | -2 | 2 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
44283086 | 126112 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 482 | 8 | 2 | 2 | 7.2 | CC(/C=C/CCc1ccccc1)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1021/jm00086a017 | |||
CHEMBL34422 | 126112 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 482 | 8 | 2 | 2 | 7.2 | CC(/C=C/CCc1ccccc1)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1021/jm00086a017 | |||
10008405 | 125568 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 580 | 9 | 4 | 5 | 3.9 | O=C(O)C[C@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@@H]2C[C@H](NC(=O)OCc3ccccc3)C(=O)N12 | 10.1016/s0960-894x(98)00677-5 | |||
CHEMBL342110 | 125568 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 580 | 9 | 4 | 5 | 3.9 | O=C(O)C[C@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@@H]2C[C@H](NC(=O)OCc3ccccc3)C(=O)N12 | 10.1016/s0960-894x(98)00677-5 | |||
CHEMBL169174 | 215615 | 0 | None | - | 0 | Mouse | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1)C(=O)N1CC(=O)N[C@@H](Cc2ccccc2)C1 | 10.1016/S0960-894X(01)80253-5 | |||||
44333997 | 115536 | 0 | None | - | 0 | Guinea pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 588 | 10 | 3 | 5 | 5.3 | CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N1CCC(C(=O)c2ccccc2)CC1 | 10.1016/0960-894X(95)00537-3 | |||
CHEMBL320886 | 115536 | 0 | None | - | 0 | Guinea pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 588 | 10 | 3 | 5 | 5.3 | CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N1CCC(C(=O)c2ccccc2)CC1 | 10.1016/0960-894X(95)00537-3 | |||
10551234 | 103716 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 443 | 6 | 3 | 6 | 4.6 | Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(OC(C)C)c2)c1 | 10.1021/jm970373j | |||
CHEMBL266120 | 103716 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 443 | 6 | 3 | 6 | 4.6 | Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(OC(C)C)c2)c1 | 10.1021/jm970373j | |||
6956374 | 9184 | 5 | None | - | 1 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 435 | 3 | 2 | 2 | 4.9 | Brc1ccc(cc1)NC(=O)N1NC(=O)[C@@H]([C@H]1c1ccccc1)c1ccccc1 | 10.1021/jm000937a | |||
902 | 9184 | 5 | None | - | 1 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 435 | 3 | 2 | 2 | 4.9 | Brc1ccc(cc1)NC(=O)N1NC(=O)[C@@H]([C@H]1c1ccccc1)c1ccccc1 | 10.1021/jm000937a | |||
CHEMBL117281 | 9184 | 5 | None | - | 1 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 435 | 3 | 2 | 2 | 4.9 | Brc1ccc(cc1)NC(=O)N1NC(=O)[C@@H]([C@H]1c1ccccc1)c1ccccc1 | 10.1021/jm000937a | |||
6956374 | 9184 | 5 | None | - | 1 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 435 | 3 | 2 | 2 | 4.9 | Brc1ccc(cc1)NC(=O)N1NC(=O)[C@@H]([C@H]1c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(00)80684-8 | |||
902 | 9184 | 5 | None | - | 1 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 435 | 3 | 2 | 2 | 4.9 | Brc1ccc(cc1)NC(=O)N1NC(=O)[C@@H]([C@H]1c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(00)80684-8 | |||
CHEMBL117281 | 9184 | 5 | None | - | 1 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 435 | 3 | 2 | 2 | 4.9 | Brc1ccc(cc1)NC(=O)N1NC(=O)[C@@H]([C@H]1c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(00)80684-8 | |||
2118 | 210264 | 36 | None | - | 2 | Rat | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 308 | 1 | 0 | 4 | 3.6 | Cc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1)=NC2 | 10.1021/jm00396a028 | |||
CHEMBL661 | 210264 | 36 | None | - | 2 | Rat | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 308 | 1 | 0 | 4 | 3.6 | Cc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1)=NC2 | 10.1021/jm00396a028 | |||
CHEMBL2372078 | 216963 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H]1CNC(=O)CNC(=O)[C@H](CCCNCc2ccccc2)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1016/j.bmc.2007.05.067 | |||||
CHEMBL383458 | 219092 | 0 | None | -10 | 4 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm050921q | |||||
10409900 | 110635 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 420 | 3 | 2 | 3 | 4.5 | Cc1cccc(NC(=O)N[C@@H]2C[C@@H](N3CCCCCC3)c3ccccc3N(C)C2=O)c1 | 10.1016/0960-894X(95)00234-K | |||
CHEMBL30919 | 110635 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 420 | 3 | 2 | 3 | 4.5 | Cc1cccc(NC(=O)N[C@@H]2C[C@@H](N3CCCCCC3)c3ccccc3N(C)C2=O)c1 | 10.1016/0960-894X(95)00234-K | |||
44318205 | 212573 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 459 | 3 | 3 | 4 | 3.9 | CN1C(=O)[C@H](NC(=O)Nc2ccc3c(c2)CCC3)N=C([C@H]2CC(C)(C)CCN2)c2ccccc21 | 10.1021/jm9608523 | |||
CHEMBL83130 | 212573 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 459 | 3 | 3 | 4 | 3.9 | CN1C(=O)[C@H](NC(=O)Nc2ccc3c(c2)CCC3)N=C([C@H]2CC(C)(C)CCN2)c2ccccc21 | 10.1021/jm9608523 | |||
44303515 | 108870 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 571 | 9 | 2 | 5 | 5.3 | CN(C)C(=O)c1oc2ccccc2c1CC(C)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 | 10.1016/S0960-894X(97)00356-9 | |||
CHEMBL302194 | 108870 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 571 | 9 | 2 | 5 | 5.3 | CN(C)C(=O)c1oc2ccccc2c1CC(C)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 | 10.1016/S0960-894X(97)00356-9 | |||
10363545 | 212520 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 399 | 3 | 2 | 4 | 3.4 | Cc1cccc(NC(=O)NC2N=C(c3ccccn3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00078a018 | |||
CHEMBL82685 | 212520 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 399 | 3 | 2 | 4 | 3.4 | Cc1cccc(NC(=O)NC2N=C(c3ccccn3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00078a018 | |||
10363545 | 212520 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 399 | 3 | 2 | 4 | 3.4 | Cc1cccc(NC(=O)NC2N=C(c3ccccn3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm9608523 | |||
CHEMBL82685 | 212520 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 399 | 3 | 2 | 4 | 3.4 | Cc1cccc(NC(=O)NC2N=C(c3ccccn3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm9608523 | |||
90663984 | 113591 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 841 | 21 | 8 | 8 | 3.4 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(F)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
CHEMBL3144553 | 113591 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 841 | 21 | 8 | 8 | 3.4 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(F)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
118719193 | 122236 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 520 | 7 | 2 | 5 | 3.6 | CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@H]12 | 10.1021/jm991078x | |||
CHEMBL3350871 | 122236 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 520 | 7 | 2 | 5 | 3.6 | CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@H]12 | 10.1021/jm991078x | |||
CHEMBL3142685 | 217907 | 0 | None | - | 0 | Guinea pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | None | None | None | Cc1ccccc1NC(=O)NCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||||
10413618 | 209570 | 0 | None | - | 1 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 499 | 8 | 3 | 3 | 5.4 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 | 10.1016/s0960-894x(00)00198-0 | |||
CHEMBL62205 | 209570 | 0 | None | - | 1 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 499 | 8 | 3 | 3 | 5.4 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 | 10.1016/s0960-894x(00)00198-0 | |||
9983419 | 116164 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 499 | 8 | 3 | 3 | 5.4 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccc1 | 10.1021/jm00105a062 | |||
CHEMBL321946 | 116164 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 499 | 8 | 3 | 3 | 5.4 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccc1 | 10.1021/jm00105a062 | |||
10413618 | 209570 | 0 | None | - | 1 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 499 | 8 | 3 | 3 | 5.4 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 | 10.1016/S0960-894X(97)00356-9 | |||
CHEMBL62205 | 209570 | 0 | None | - | 1 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 499 | 8 | 3 | 3 | 5.4 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 | 10.1016/S0960-894X(97)00356-9 | |||
44280200 | 107601 | 0 | None | - | 1 | Mouse | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 785 | 18 | 4 | 7 | 6.6 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
CHEMBL29331 | 107601 | 0 | None | - | 1 | Mouse | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 785 | 18 | 4 | 7 | 6.6 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
10413618 | 209570 | 0 | None | - | 1 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 499 | 8 | 3 | 3 | 5.4 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 | 10.1021/jm970065l | |||
CHEMBL62205 | 209570 | 0 | None | - | 1 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 499 | 8 | 3 | 3 | 5.4 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 | 10.1021/jm970065l | |||
15719750 | 85258 | 0 | None | - | 0 | Rat | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 446 | 9 | 3 | 3 | 4.0 | O=C(O)CC[C@H](NC(=O)c1cccc(Cl)c1)C(=O)NCCC12CC3CC(CC(C3)C1)C2 | 10.1021/jm00079a003 | |||
CHEMBL2111825 | 85258 | 0 | None | - | 0 | Rat | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 446 | 9 | 3 | 3 | 4.0 | O=C(O)CC[C@H](NC(=O)c1cccc(Cl)c1)C(=O)NCCC12CC3CC(CC(C3)C1)C2 | 10.1021/jm00079a003 | |||
13605417 | 214347 | 4 | None | - | 1 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 458 | 14 | 2 | 3 | 5.2 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1ccc(Cl)c(Cl)c1 | 10.1021/jm00124a003 | |||
CHEMBL9485 | 214347 | 4 | None | - | 1 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 458 | 14 | 2 | 3 | 5.2 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1ccc(Cl)c(Cl)c1 | 10.1021/jm00124a003 | |||
54581301 | 68693 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 503 | 5 | 1 | 5 | 5.6 | COc1ccc(-c2cnc(C(=O)N3CCN(c4ccc5cc[nH]c5c4)CC3)nc2-c2ccc(C)cc2)cc1 | 10.1016/j.bmcl.2011.03.069 | |||
CHEMBL1774038 | 68693 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 503 | 5 | 1 | 5 | 5.6 | COc1ccc(-c2cnc(C(=O)N3CCN(c4ccc5cc[nH]c5c4)CC3)nc2-c2ccc(C)cc2)cc1 | 10.1016/j.bmcl.2011.03.069 | |||
15167812 | 108973 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 437 | 3 | 1 | 3 | 3.6 | CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)[N+]([O-])=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL302825 | 108973 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 437 | 3 | 1 | 3 | 3.6 | CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)[N+]([O-])=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
13605417 | 214347 | 4 | None | - | 1 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 458 | 14 | 2 | 3 | 5.2 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1ccc(Cl)c(Cl)c1 | 10.1021/jm00116a002 | |||
CHEMBL9485 | 214347 | 4 | None | - | 1 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 458 | 14 | 2 | 3 | 5.2 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1ccc(Cl)c(Cl)c1 | 10.1021/jm00116a002 | |||
44368382 | 52113 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 511 | 9 | 4 | 4 | 4.5 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1CCCCC1Cl)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
CHEMBL152682 | 52113 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 511 | 9 | 4 | 4 | 4.5 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1CCCCC1Cl)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
10480792 | 52574 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 491 | 9 | 4 | 4 | 4.5 | CC1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
CHEMBL153095 | 52574 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 491 | 9 | 4 | 4 | 4.5 | CC1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
CHEMBL3350686 | 52574 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 491 | 9 | 4 | 4 | 4.5 | CC1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
136242438 | 85401 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 671 | 12 | 6 | 7 | 4.2 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CSc1n[nH]c(=O)[nH]1)c1ccccc1 | 10.1021/jm00092a007 | |||
CHEMBL2112333 | 85401 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 671 | 12 | 6 | 7 | 4.2 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CSc1n[nH]c(=O)[nH]1)c1ccccc1 | 10.1021/jm00092a007 | |||
10699165 | 118230 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 625 | 7 | 1 | 4 | 6.9 | CC(C)N(C(=O)CN1C(=O)C(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc21)c1ccc(C(F)(F)F)cc1 | 10.1021/jm970265x | |||
CHEMBL327552 | 118230 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 625 | 7 | 1 | 4 | 6.9 | CC(C)N(C(=O)CN1C(=O)C(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc21)c1ccc(C(F)(F)F)cc1 | 10.1021/jm970265x | |||
44211352 | 20757 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 522 | 6 | 1 | 4 | 3.8 | CN1CCN(C(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCC3)CC2)CC1 | 10.1016/S0960-894X(00)80681-2 | |||
CHEMBL1196916 | 20757 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 522 | 6 | 1 | 4 | 3.8 | CN1CCN(C(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCC3)CC2)CC1 | 10.1016/S0960-894X(00)80681-2 | |||
CHEMBL558614 | 20757 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 522 | 6 | 1 | 4 | 3.8 | CN1CCN(C(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCC3)CC2)CC1 | 10.1016/S0960-894X(00)80681-2 | |||
11744065 | 85588 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 442 | 4 | 2 | 5 | 3.6 | CC(=O)Oc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00078a018 | |||
CHEMBL2112750 | 85588 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 442 | 4 | 2 | 5 | 3.6 | CC(=O)Oc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00078a018 | |||
15167809 | 74489 | 0 | None | - | 0 | Guinea pig | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 440 | 5 | 2 | 3 | 3.6 | NC(=O)CN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00390a019 | |||
CHEMBL1907725 | 74489 | 0 | None | - | 0 | Guinea pig | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 440 | 5 | 2 | 3 | 3.6 | NC(=O)CN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00390a019 | |||
135703408 | 149614 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 511 | 4 | 2 | 6 | 6.0 | O=C1c2ccccc2C(=O)N1Cc1c(O)ccc2c(/C=C/c3ccc(O)cc3)cc3nc4ccccc4n3c12 | 10.1016/j.bmcl.2007.02.071 | |||
CHEMBL389311 | 149614 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 511 | 4 | 2 | 6 | 6.0 | O=C1c2ccccc2C(=O)N1Cc1c(O)ccc2c(/C=C/c3ccc(O)cc3)cc3nc4ccccc4n3c12 | 10.1016/j.bmcl.2007.02.071 | |||
44349254 | 23605 | 0 | None | - | 0 | Rat | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 354 | 10 | 3 | 3 | 2.6 | CCCCCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 | 10.1021/jm00079a003 | |||
CHEMBL124751 | 23605 | 0 | None | - | 0 | Rat | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 354 | 10 | 3 | 3 | 2.6 | CCCCCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 | 10.1021/jm00079a003 | |||
23129945 | 16382 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 604 | 16 | 2 | 4 | 7.8 | CCCCCN(CCCCC)C(=O)C(Cc1c[nH]c2ccc(OCc3ccccc3)cc12)NC(=O)c1cnc2ccccc2c1 | 10.1021/jm00116a002 | |||
CHEMBL112612 | 16382 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 604 | 16 | 2 | 4 | 7.8 | CCCCCN(CCCCC)C(=O)C(Cc1c[nH]c2ccc(OCc3ccccc3)cc12)NC(=O)c1cnc2ccccc2c1 | 10.1021/jm00116a002 | |||
14888721 | 84012 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 1055 | 30 | 11 | 14 | -0.2 | CSCC[C@H](NC(=O)[C@H](Cc1ccc(Cc2nnn[nH]2)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00107a037 | |||
CHEMBL2079551 | 84012 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 1055 | 30 | 11 | 14 | -0.2 | CSCC[C@H](NC(=O)[C@H](Cc1ccc(Cc2nnn[nH]2)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00107a037 | |||
CHEMBL350222 | 218502 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | None | None | None | Cc1ccccc1NC(=O)N(C)CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00031a013 | |||||
22354599 | 201584 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 517 | 6 | 2 | 5 | 4.9 | Cc1cccc(NC(=O)NC2N=C(c3ccncc3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1 | 10.1016/0960-894X(95)00557-A | |||
CHEMBL538912 | 201584 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 517 | 6 | 2 | 5 | 4.9 | Cc1cccc(NC(=O)NC2N=C(c3ccncc3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1 | 10.1016/0960-894X(95)00557-A | |||
15104600 | 103861 | 0 | None | - | 0 | Guinea pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 515 | 13 | 2 | 2 | 7.0 | CCCCCN(CCCCC)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccc(Cl)c(Cl)c1 | 10.1021/jm00116a002 | |||
CHEMBL267339 | 103861 | 0 | None | - | 0 | Guinea pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 515 | 13 | 2 | 2 | 7.0 | CCCCCN(CCCCC)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccc(Cl)c(Cl)c1 | 10.1021/jm00116a002 | |||
10484212 | 106655 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 635 | 6 | 3 | 7 | 4.3 | Cc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(-c3nn[nH]n3)c1)N=C2c1ccccc1F | 10.1016/S0960-894X(96)00609-9 | |||
CHEMBL285921 | 106655 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 635 | 6 | 3 | 7 | 4.3 | Cc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(-c3nn[nH]n3)c1)N=C2c1ccccc1F | 10.1016/S0960-894X(96)00609-9 | |||
45482488 | 205084 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 441 | 7 | 4 | 3 | 4.2 | Cc1cccc2cc(C(=O)Nc3ccccc3C(=O)NC(Cc3ccccc3)C(=O)O)[nH]c12 | 10.1016/j.bmc.2009.05.067 | |||
CHEMBL576021 | 205084 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 441 | 7 | 4 | 3 | 4.2 | Cc1cccc2cc(C(=O)Nc3ccccc3C(=O)NC(Cc3ccccc3)C(=O)O)[nH]c12 | 10.1016/j.bmc.2009.05.067 | |||
44327458 | 214636 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 571 | 11 | 3 | 4 | 5.6 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCC(=O)O)CCc1ccccc1 | 10.1016/S0960-894X(01)80769-1 | |||
CHEMBL96469 | 214636 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 571 | 11 | 3 | 4 | 5.6 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCC(=O)O)CCc1ccccc1 | 10.1016/S0960-894X(01)80769-1 | |||
44379965 | 64612 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 496 | 6 | 2 | 5 | 5.5 | CC(C)Oc1cccc(-n2c(CNC(=O)Nc3ccc(C(F)(F)F)cc3)nc3ccccc3c2=O)c1 | 10.1016/S0960-894X(97)00108-X | |||
CHEMBL167169 | 64612 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 496 | 6 | 2 | 5 | 5.5 | CC(C)Oc1cccc(-n2c(CNC(=O)Nc3ccc(C(F)(F)F)cc3)nc3ccccc3c2=O)c1 | 10.1016/S0960-894X(97)00108-X | |||
44349335 | 124091 | 0 | None | - | 0 | Rat | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 401 | 7 | 3 | 4 | 2.6 | Cc1cccc(C(=O)NC(CCC(=O)O)C(=O)NN2CCC3(CCCC3)CC2)c1 | 10.1021/jm00079a003 | |||
CHEMBL339707 | 124091 | 0 | None | - | 0 | Rat | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 401 | 7 | 3 | 4 | 2.6 | Cc1cccc(C(=O)NC(CCC(=O)O)C(=O)NN2CCC3(CCCC3)CC2)c1 | 10.1021/jm00079a003 | |||
52949124 | 7663 | 4 | None | -2 | 2 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
9055 | 7663 | 4 | None | -2 | 2 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
CHEMBL1269258 | 7663 | 4 | None | -2 | 2 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
DB12694 | 7663 | 4 | None | -2 | 2 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
10252366 | 32656 | 14 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 434 | 3 | 2 | 3 | 4.8 | CN1C(=O)C(NC(=O)Nc2cccc3ccccc23)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL135364 | 32656 | 14 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 434 | 3 | 2 | 3 | 4.8 | CN1C(=O)C(NC(=O)Nc2cccc3ccccc23)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
10649606 | 56390 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 519 | 6 | 3 | 4 | 4.5 | O=C(CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)Nc1ccccc1 | 10.1016/j.bmcl.2015.03.051 | |||
CHEMBL156605 | 56390 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 519 | 6 | 3 | 4 | 4.5 | O=C(CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)Nc1ccccc1 | 10.1016/j.bmcl.2015.03.051 | |||
70683295 | 80371 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 606 | 7 | 1 | 5 | 6.2 | O=C(CN1C(=O)C(Cc2c[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc21)N1CCC(Cc2ccccc2)C1 | 10.1016/j.bmcl.2012.02.049 | |||
CHEMBL2017692 | 80371 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 606 | 7 | 1 | 5 | 6.2 | O=C(CN1C(=O)C(Cc2c[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc21)N1CCC(Cc2ccccc2)C1 | 10.1016/j.bmcl.2012.02.049 | |||
73355866 | 213011 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 717 | 13 | 5 | 6 | 4.8 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCNS(=O)(=O)C(F)(F)F)c1ccccc1 | 10.1021/jm00092a007 | |||
CHEMBL86702 | 213011 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 717 | 13 | 5 | 6 | 4.8 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCNS(=O)(=O)C(F)(F)F)c1ccccc1 | 10.1021/jm00092a007 | |||
71454457 | 85398 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 655 | 12 | 5 | 7 | 4.9 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CSc1nc[nH]n1)c1ccccc1 | 10.1021/jm00092a007 | |||
CHEMBL2112330 | 85398 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 655 | 12 | 5 | 7 | 4.9 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CSc1nc[nH]n1)c1ccccc1 | 10.1021/jm00092a007 | |||
44370393 | 126422 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 492 | 14 | 2 | 3 | 5.4 | CCCCCN(CCCCC)C(=O)C(CCC(=O)N1CCCC1)NC(=O)Nc1ccc(Cl)cc1 | 10.1021/jm00164a020 | |||
CHEMBL346784 | 126422 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 492 | 14 | 2 | 3 | 5.4 | CCCCCN(CCCCC)C(=O)C(CCC(=O)N1CCCC1)NC(=O)Nc1ccc(Cl)cc1 | 10.1021/jm00164a020 | |||
15673149 | 92767 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 717 | 13 | 5 | 6 | 4.8 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCNS(=O)(=O)C(F)(F)F)c1ccccc1 | 10.1016/S0960-894X(00)80652-6 | |||
CHEMBL2304151 | 92767 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 717 | 13 | 5 | 6 | 4.8 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCNS(=O)(=O)C(F)(F)F)c1ccccc1 | 10.1016/S0960-894X(00)80652-6 | |||
44349412 | 23637 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 396 | 12 | 3 | 3 | 3.6 | CCCCC(CC)CNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 | 10.1021/jm00079a003 | |||
CHEMBL124917 | 23637 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 396 | 12 | 3 | 3 | 3.6 | CCCCC(CC)CNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 | 10.1021/jm00079a003 | |||
10361419 | 33226 | 13 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 364 | 2 | 2 | 3 | 2.9 | CN1C(=O)C(NC(=O)NC(C)(C)C)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL135988 | 33226 | 13 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 364 | 2 | 2 | 3 | 2.9 | CN1C(=O)C(NC(=O)NC(C)(C)C)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
44303243 | 209704 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 545 | 9 | 5 | 5 | 4.2 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CO)[C@H](O)c1ccccc1 | 10.1016/S0960-894X(97)00356-9 | |||
CHEMBL62832 | 209704 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 545 | 9 | 5 | 5 | 4.2 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CO)[C@H](O)c1ccccc1 | 10.1016/S0960-894X(97)00356-9 | |||
10507071 | 120387 | 0 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 559 | 7 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm0501127 | |||
CHEMBL332261 | 120387 | 0 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 559 | 7 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm0501127 | |||
10553685 | 125929 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 508 | 8 | 3 | 5 | 4.2 | COC[C@@H]1CCCN1NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 | 10.1021/jm970065l | |||
CHEMBL342907 | 125929 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 508 | 8 | 3 | 5 | 4.2 | COC[C@@H]1CCCN1NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 | 10.1021/jm970065l | |||
9985100 | 121280 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 552 | 5 | 3 | 3 | 6.0 | CC(C)(C)NC(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](c2cccc(Cl)c2)c2ccccc21 | 10.1021/jm00048a015 | |||
CHEMBL333541 | 121280 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 552 | 5 | 3 | 3 | 6.0 | CC(C)(C)NC(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](c2cccc(Cl)c2)c2ccccc21 | 10.1021/jm00048a015 | |||
44368611 | 128772 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 541 | 10 | 4 | 3 | 4.9 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)C1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CC(=O)O)Cc1ccccc1 | 10.1021/jm00057a005 | |||
CHEMBL359292 | 128772 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 541 | 10 | 4 | 3 | 4.9 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)C1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CC(=O)O)Cc1ccccc1 | 10.1021/jm00057a005 | |||
14208273 | 74512 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 457 | 7 | 1 | 3 | 5.1 | CCCCCc1ccc(C(=O)N[C@H]2N=C(c3ccccc3F)c3ccccc3N(C)C2=O)cc1 | 10.1021/jm00120a002 | |||
CHEMBL1907840 | 74512 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 457 | 7 | 1 | 3 | 5.1 | CCCCCc1ccc(C(=O)N[C@H]2N=C(c3ccccc3F)c3ccccc3N(C)C2=O)cc1 | 10.1021/jm00120a002 | |||
44334172 | 11341 | 1 | None | - | 0 | Guinea pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 556 | 10 | 3 | 5 | 4.9 | Cc1cccc(NC(=O)N[C@H](CCC(=O)OCc2ccccc2)C(=O)N2CCC(C(=O)Nc3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
CHEMBL102526 | 11341 | 1 | None | - | 0 | Guinea pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 556 | 10 | 3 | 5 | 4.9 | Cc1cccc(NC(=O)N[C@H](CCC(=O)OCc2ccccc2)C(=O)N2CCC(C(=O)Nc3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
44379640 | 64360 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 522 | 6 | 2 | 5 | 5.8 | CC(C)Oc1cccc(-n2c(C/N=C(\S)Nc3ccc(Br)cc3)nc3ccccc3c2=O)c1 | 10.1016/S0960-894X(97)00108-X | |||
CHEMBL166737 | 64360 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 522 | 6 | 2 | 5 | 5.8 | CC(C)Oc1cccc(-n2c(C/N=C(\S)Nc3ccc(Br)cc3)nc3ccccc3c2=O)c1 | 10.1016/S0960-894X(97)00108-X | |||
44303470 | 210044 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 479 | 8 | 2 | 5 | 4.5 | Cc1noc(C)c1CC(C)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 | 10.1016/S0960-894X(97)00356-9 | |||
CHEMBL64623 | 210044 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 479 | 8 | 2 | 5 | 4.5 | Cc1noc(C)c1CC(C)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 | 10.1016/S0960-894X(97)00356-9 | |||
CHEMBL2372079 | 216964 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H]1CNC(=O)CNC(=O)[C@H](CCNCc2ccccc2)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1016/j.bmc.2007.05.067 | |||||
44286836 | 168504 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 810 | 19 | 6 | 7 | 4.8 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N(C)CCC(=O)N(C)C(Cc1ccccc1)C(N)=O | 10.1021/jm00037a005 | |||
CHEMBL41364 | 168504 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 810 | 19 | 6 | 7 | 4.8 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N(C)CCC(=O)N(C)C(Cc1ccccc1)C(N)=O | 10.1021/jm00037a005 | |||
15692562 | 116413 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 473 | 14 | 4 | 6 | 3.8 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1cc(O)c2cccc(O)c2n1 | 10.1021/jm00116a002 | |||
CHEMBL322284 | 116413 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 473 | 14 | 4 | 6 | 3.8 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1cc(O)c2cccc(O)c2n1 | 10.1021/jm00116a002 | |||
10700916 | 181215 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 896 | 26 | 9 | 9 | 2.1 | CCCC[C@H](NC(=O)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL4553223 | 181215 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 896 | 26 | 9 | 9 | 2.1 | CCCC[C@H](NC(=O)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
46235271 | 80423 | 2 | None | 2 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 649 | 7 | 1 | 6 | 6.7 | Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1021/acs.jmedchem.5b01110 | |||
CHEMBL2017835 | 80423 | 2 | None | 2 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 649 | 7 | 1 | 6 | 6.7 | Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1021/acs.jmedchem.5b01110 | |||
CHEMBL2310858 | 216269 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | None | None | None | CCCC1CCN([C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc2ccccc2)C(N)=O)[C@H]1C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)CCc1ccc(OS(=O)(=O)O)cc1 | 10.1021/jm00094a001 | |||||
44293999 | 195204 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 597 | 6 | 2 | 5 | 5.1 | COc1cccc(NC(=O)NC2N=C(c3ccccc3F)c3cccc(C)c3N(CC(=O)N3CC4CCC(CC4)C3)C2=O)c1 | 10.1016/S0960-894X(96)00609-9 | |||
CHEMBL50216 | 195204 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 597 | 6 | 2 | 5 | 5.1 | COc1cccc(NC(=O)NC2N=C(c3ccccc3F)c3cccc(C)c3N(CC(=O)N3CC4CCC(CC4)C3)C2=O)c1 | 10.1016/S0960-894X(96)00609-9 | |||
9985667 | 170140 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 580 | 9 | 4 | 5 | 3.9 | O=C(O)C[C@@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@H]2C[C@H](NC(=O)OCc3ccccc3)C(=O)N12 | 10.1021/jm000959x | |||
CHEMBL419237 | 170140 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 580 | 9 | 4 | 5 | 3.9 | O=C(O)C[C@@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@H]2C[C@H](NC(=O)OCc3ccccc3)C(=O)N12 | 10.1021/jm000959x | |||
44293811 | 191898 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 601 | 5 | 2 | 4 | 5.8 | Cc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(Cl)c1)N=C2c1ccccc1F | 10.1016/S0960-894X(96)00609-9 | |||
CHEMBL48563 | 191898 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 601 | 5 | 2 | 4 | 5.8 | Cc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(Cl)c1)N=C2c1ccccc1F | 10.1016/S0960-894X(96)00609-9 | |||
9985667 | 170140 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 580 | 9 | 4 | 5 | 3.9 | O=C(O)C[C@@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@H]2C[C@H](NC(=O)OCc3ccccc3)C(=O)N12 | 10.1016/s0960-894x(98)00677-5 | |||
CHEMBL419237 | 170140 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 580 | 9 | 4 | 5 | 3.9 | O=C(O)C[C@@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@H]2C[C@H](NC(=O)OCc3ccccc3)C(=O)N12 | 10.1016/s0960-894x(98)00677-5 | |||
14590302 | 108215 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 444 | 4 | 1 | 4 | 4.3 | CC(C)(C)OC(=O)CN1C(=O)C(NC(=O)c2ccc3ccccc3c2)CCc2ccccc21 | 10.1016/S0960-894X(00)80683-6 | |||
CHEMBL297534 | 108215 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 444 | 4 | 1 | 4 | 4.3 | CC(C)(C)OC(=O)CN1C(=O)C(NC(=O)c2ccc3ccccc3c2)CCc2ccccc21 | 10.1016/S0960-894X(00)80683-6 | |||
367893 | 58394 | 1 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 429 | 14 | 3 | 3 | 4.3 | CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)O)NC(=O)c1cc2ccccc2[nH]1 | 10.1021/jm00164a020 | |||
CHEMBL158362 | 58394 | 1 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 429 | 14 | 3 | 3 | 4.3 | CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)O)NC(=O)c1cc2ccccc2[nH]1 | 10.1021/jm00164a020 | |||
10048986 | 34327 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 442 | 5 | 3 | 4 | 3.4 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)O)C2=O)c1 | 10.1021/jm00078a018 | |||
CHEMBL136919 | 34327 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 442 | 5 | 3 | 4 | 3.4 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)O)C2=O)c1 | 10.1021/jm00078a018 | |||
10816889 | 85615 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 570 | 8 | 3 | 6 | 4.5 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)[C@H](C#N)N[C@@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm991078x | |||
CHEMBL2112824 | 85615 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 570 | 8 | 3 | 6 | 4.5 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)[C@H](C#N)N[C@@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm991078x | |||
136046102 | 107453 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 864 | 20 | 9 | 10 | 3.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1cnc2cccc(O)c2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
CHEMBL292298 | 107453 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 864 | 20 | 9 | 10 | 3.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1cnc2cccc(O)c2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
11742839 | 19596 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 419 | 2 | 2 | 4 | 3.7 | Cc1cccc(NC(=O)N[C@H]2N=C(N3CCCCCC3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00032a002 | |||
CHEMBL1188361 | 19596 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 419 | 2 | 2 | 4 | 3.7 | Cc1cccc(NC(=O)N[C@H]2N=C(N3CCCCCC3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00032a002 | |||
CHEMBL536245 | 19596 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 419 | 2 | 2 | 4 | 3.7 | Cc1cccc(NC(=O)N[C@H]2N=C(N3CCCCCC3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00032a002 | |||
10074366 | 127376 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 491 | 9 | 4 | 4 | 4.5 | C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
CHEMBL3349028 | 127376 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 491 | 9 | 4 | 4 | 4.5 | C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
CHEMBL3545866 | 127376 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 491 | 9 | 4 | 4 | 4.5 | C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
15514020 | 85366 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 603 | 7 | 3 | 7 | 4.0 | CC(=O)Oc1cccc(N2C(=O)C[C@H]3[C@H](NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)OC(C)(C)C)CCCN3C2=O)c1 | 10.1021/jm010813d | |||
CHEMBL2112232 | 85366 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 603 | 7 | 3 | 7 | 4.0 | CC(=O)Oc1cccc(N2C(=O)C[C@H]3[C@H](NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)OC(C)(C)C)CCCN3C2=O)c1 | 10.1021/jm010813d | |||
14208234 | 211478 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 428 | 3 | 4 | 4 | 3.6 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1cc2cc(O)ccc2[nH]1 | 10.1021/jm00047a021 | |||
CHEMBL74066 | 211478 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 428 | 3 | 4 | 4 | 3.6 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1cc2cc(O)ccc2[nH]1 | 10.1021/jm00047a021 | |||
46235271 | 80423 | 2 | None | 2 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 649 | 7 | 1 | 6 | 6.7 | Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1021/acs.jmedchem.5b01110 | |||
CHEMBL2017835 | 80423 | 2 | None | 2 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 649 | 7 | 1 | 6 | 6.7 | Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1021/acs.jmedchem.5b01110 | |||
14208270 | 74526 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 447 | 3 | 1 | 3 | 4.0 | CN1C(=O)[C@H](NC(=O)c2ccc(Br)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL1907853 | 74526 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 447 | 3 | 1 | 3 | 4.0 | CN1C(=O)[C@H](NC(=O)c2ccc(Br)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
13809511 | 109071 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 512 | 6 | 2 | 5 | 4.1 | CN1C(=O)C(NC(=O)[C@@H](Cc2ccccc2)NC(=O)OC(C)(C)C)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL303386 | 109071 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 512 | 6 | 2 | 5 | 4.1 | CN1C(=O)C(NC(=O)[C@@H](Cc2ccccc2)NC(=O)OC(C)(C)C)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
15060278 | 127576 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 633 | 12 | 3 | 5 | 6.5 | O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1)OCc1ccccc1 | 10.1016/S0960-894X(00)80687-3 | |||
CHEMBL355532 | 127576 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 633 | 12 | 3 | 5 | 6.5 | O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1)OCc1ccccc1 | 10.1016/S0960-894X(00)80687-3 | |||
44329287 | 214414 | 0 | None | - | 0 | Guinea pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 544 | 6 | 3 | 3 | 5.7 | Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccc(F)cc3)C[C@H](c3ccccc3)N(CC(=O)NC(C)(C)C)C2=O)c1 | 10.1016/S0960-894X(01)80832-5 | |||
CHEMBL95209 | 214414 | 0 | None | - | 0 | Guinea pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 544 | 6 | 3 | 3 | 5.7 | Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccc(F)cc3)C[C@H](c3ccccc3)N(CC(=O)NC(C)(C)C)C2=O)c1 | 10.1016/S0960-894X(01)80832-5 | |||
10815039 | 119624 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 493 | 5 | 2 | 5 | 4.5 | CC(C)(C)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C#N)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm960669+ | |||
CHEMBL330917 | 119624 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 493 | 5 | 2 | 5 | 4.5 | CC(C)(C)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C#N)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm960669+ | |||
15614750 | 126101 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 426 | 4 | 3 | 3 | 3.9 | O=C(NCC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1cc2ccccc2[nH]1 | 10.1021/jm00163a069 | |||
CHEMBL344154 | 126101 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 426 | 4 | 3 | 3 | 3.9 | O=C(NCC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1cc2ccccc2[nH]1 | 10.1021/jm00163a069 | |||
10744557 | 39500 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 521 | 7 | 4 | 4 | 4.8 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1CCCCC1C(=O)O | 10.1021/jm970065l | |||
CHEMBL141370 | 39500 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 521 | 7 | 4 | 4 | 4.8 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1CCCCC1C(=O)O | 10.1021/jm970065l | |||
44372047 | 163909 | 0 | None | - | 0 | Guinea pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 854 | 20 | 7 | 8 | 4.2 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)N(C)C(=O)OC(C)(C)C)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00031a013 | |||
CHEMBL407507 | 163909 | 0 | None | - | 0 | Guinea pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 854 | 20 | 7 | 8 | 4.2 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)N(C)C(=O)OC(C)(C)C)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00031a013 | |||
16100410 | 148576 | 0 | None | -6309 | 4 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 1031 | 27 | 13 | 12 | 0.2 | CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@H](Cc1cc2ccccc2[nH]1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm061268p | |||
CHEMBL386212 | 148576 | 0 | None | -6309 | 4 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 1031 | 27 | 13 | 12 | 0.2 | CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@H](Cc1cc2ccccc2[nH]1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm061268p | |||
11803746 | 113390 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 870 | 21 | 9 | 10 | 3.0 | COC(=O)c1ccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 | 10.1021/jm960509y | |||
CHEMBL3142904 | 113390 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 870 | 21 | 9 | 10 | 3.0 | COC(=O)c1ccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 | 10.1021/jm960509y | |||
14208230 | 109986 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 446 | 3 | 3 | 3 | 4.5 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1cc2cc(Cl)ccc2[nH]1 | 10.1021/jm00120a002 | |||
CHEMBL308414 | 109986 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 446 | 3 | 3 | 3 | 4.5 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1cc2cc(Cl)ccc2[nH]1 | 10.1021/jm00120a002 | |||
14208234 | 211478 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 428 | 3 | 4 | 4 | 3.6 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1cc2cc(O)ccc2[nH]1 | 10.1021/jm00120a002 | |||
CHEMBL74066 | 211478 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 428 | 3 | 4 | 4 | 3.6 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1cc2cc(O)ccc2[nH]1 | 10.1021/jm00120a002 | |||
10053201 | 23364 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 546 | 6 | 3 | 3 | 5.9 | CCc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2c1ccccc1 | 10.1021/jm00048a015 | |||
CHEMBL124004 | 23364 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 546 | 6 | 3 | 3 | 5.9 | CCc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2c1ccccc1 | 10.1021/jm00048a015 | |||
90663986 | 113593 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 857 | 21 | 8 | 8 | 3.9 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(Cl)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
CHEMBL3144555 | 113593 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 857 | 21 | 8 | 8 | 3.9 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(Cl)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
90663994 | 113600 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 837 | 21 | 8 | 8 | 3.6 | Cc1ccc(/C=C\C(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 | 10.1021/jm00089a010 | |||
CHEMBL3144563 | 113600 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 837 | 21 | 8 | 8 | 3.6 | Cc1ccc(/C=C\C(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 | 10.1021/jm00089a010 | |||
44283030 | 106431 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 629 | 12 | 3 | 7 | 5.4 | COC(=O)CCC(=O)N[C@H](COC(=O)C(C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)c1ccccc1 | 10.1021/jm00086a017 | |||
CHEMBL284361 | 106431 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 629 | 12 | 3 | 7 | 5.4 | COC(=O)CCC(=O)N[C@H](COC(=O)C(C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)c1ccccc1 | 10.1021/jm00086a017 | |||
11607229 | 147215 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 695 | 10 | 2 | 6 | 6.6 | COc1ccc(N(C(=O)CN2C(=O)[C@@H](NC(=O)Nc3cccc(C(=O)c4ccccc4)c3)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm049072h | |||
CHEMBL380922 | 147215 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 695 | 10 | 2 | 6 | 6.6 | COc1ccc(N(C(=O)CN2C(=O)[C@@H](NC(=O)Nc3cccc(C(=O)c4ccccc4)c3)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm049072h | |||
44370451 | 57564 | 0 | None | - | 0 | Guinea pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 435 | 15 | 3 | 4 | 4.3 | CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)O)NC(=O)Nc1cccc(OC)c1 | 10.1021/jm00164a020 | |||
CHEMBL157658 | 57564 | 0 | None | - | 0 | Guinea pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 435 | 15 | 3 | 4 | 4.3 | CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)O)NC(=O)Nc1cccc(OC)c1 | 10.1021/jm00164a020 | |||
19754255 | 65881 | 1 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 340 | 2 | 2 | 3 | 4.4 | Cn1c(C(=O)Nc2cc3c4ccccc4nc-3c[nH]2)cc2ccccc21 | 10.1016/S0960-894X(00)80682-4 | |||
CHEMBL169767 | 65881 | 1 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 340 | 2 | 2 | 3 | 4.4 | Cn1c(C(=O)Nc2cc3c4ccccc4nc-3c[nH]2)cc2ccccc21 | 10.1016/S0960-894X(00)80682-4 | |||
10094721 | 213673 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 439 | 5 | 3 | 7 | 3.5 | CN(C)c1cccc(-n2c(NNC(=O)Nc3cccc(C#N)c3)nc3ccccc3c2=O)c1 | 10.1021/jm970373j | |||
CHEMBL9083 | 213673 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 439 | 5 | 3 | 7 | 3.5 | CN(C)c1cccc(-n2c(NNC(=O)Nc3cccc(C#N)c3)nc3ccccc3c2=O)c1 | 10.1021/jm970373j | |||
19754256 | 66380 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 287 | 2 | 2 | 2 | 3.9 | O=C(Nc1cc2c3ccccc3nc-2c[nH]1)c1ccccc1 | 10.1016/S0960-894X(00)80682-4 | |||
CHEMBL171940 | 66380 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 287 | 2 | 2 | 2 | 3.9 | O=C(Nc1cc2c3ccccc3nc-2c[nH]1)c1ccccc1 | 10.1016/S0960-894X(00)80682-4 | |||
10325557 | 53282 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 563 | 9 | 4 | 4 | 5.1 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC12C[C@@H]3C[C@@H](C[C@@H](C3)C1)C2Cl)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
CHEMBL153760 | 53282 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 563 | 9 | 4 | 4 | 5.1 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC12C[C@@H]3C[C@@H](C[C@@H](C3)C1)C2Cl)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
53465907 | 76188 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 441 | 8 | 4 | 3 | 4.7 | O=C(Nc1ccccc1NC(=O)C(CCc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 | 10.1021/jm200438b | |||
CHEMBL1933109 | 76188 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 441 | 8 | 4 | 3 | 4.7 | O=C(Nc1ccccc1NC(=O)C(CCc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 | 10.1021/jm200438b | |||
44381830 | 66110 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 610 | 15 | 6 | 7 | 2.5 | N#C[C@H](N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1 | 10.1016/S0960-894X(97)00107-8 | |||
CHEMBL170664 | 66110 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 610 | 15 | 6 | 7 | 2.5 | N#C[C@H](N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1 | 10.1016/S0960-894X(97)00107-8 | |||
10051647 | 124063 | 0 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 498 | 5 | 3 | 3 | 5.2 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2C(C)C | 10.1021/jm00048a015 | |||
CHEMBL339547 | 124063 | 0 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 498 | 5 | 3 | 3 | 5.2 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2C(C)C | 10.1021/jm00048a015 | |||
21842400 | 127752 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 496 | 7 | 2 | 4 | 5.3 | CCC(C)(C)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/0960-894X(95)00556-9 | |||
CHEMBL356191 | 127752 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 496 | 7 | 2 | 4 | 5.3 | CCC(C)(C)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/0960-894X(95)00556-9 | |||
10816869 | 58627 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 569 | 8 | 3 | 5 | 5.2 | COC(=O)[C@]1(NC(=O)[C@@](C)(Cc2c[nH]c3ccccc23)NC(=O)OC2C3CC4CC(C3)CC2C4)C[C@H]1c1ccccc1 | 10.1016/S0960-894X(01)81250-6 | |||
CHEMBL158547 | 58627 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 569 | 8 | 3 | 5 | 5.2 | COC(=O)[C@]1(NC(=O)[C@@](C)(Cc2c[nH]c3ccccc23)NC(=O)OC2C3CC4CC(C3)CC2C4)C[C@H]1c1ccccc1 | 10.1016/S0960-894X(01)81250-6 | |||
20063261 | 29897 | 14 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 412 | 3 | 2 | 3 | 4.3 | Cc1cc(C)cc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00078a018 | |||
CHEMBL133087 | 29897 | 14 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 412 | 3 | 2 | 3 | 4.3 | Cc1cc(C)cc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00078a018 | |||
44280713 | 106808 | 0 | None | - | 1 | Mouse | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 740 | 15 | 6 | 9 | 3.6 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCCC(=O)NCCSCc3csc(N=C(N)N)n3)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
CHEMBL286907 | 106808 | 0 | None | - | 1 | Mouse | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 740 | 15 | 6 | 9 | 3.6 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCCC(=O)NCCSCc3csc(N=C(N)N)n3)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
44382486 | 66194 | 0 | None | - | 0 | Mouse | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 518 | 11 | 4 | 4 | 2.8 | CCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N1C[C@H](Cc2ccccc2)NC(=O)[C@@H]1CC(=O)O | 10.1016/S0960-894X(01)80253-5 | |||
CHEMBL171051 | 66194 | 0 | None | - | 0 | Mouse | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 518 | 11 | 4 | 4 | 2.8 | CCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N1C[C@H](Cc2ccccc2)NC(=O)[C@@H]1CC(=O)O | 10.1016/S0960-894X(01)80253-5 | |||
CHEMBL2372081 | 216966 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H]1CNC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1016/j.bmc.2007.05.067 | |||||
44303650 | 107556 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 548 | 6 | 2 | 3 | 6.4 | O=C(NC1(C(=O)NCCc2ccccc2)CC2(Cc3cccc4cccc(c34)C2)C1)OC1C2CC3CC(C2)CC1C3 | 10.1016/S0960-894X(97)00356-9 | |||
CHEMBL292956 | 107556 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 548 | 6 | 2 | 3 | 6.4 | O=C(NC1(C(=O)NCCc2ccccc2)CC2(Cc3cccc4cccc(c34)C2)C1)OC1C2CC3CC(C2)CC1C3 | 10.1016/S0960-894X(97)00356-9 | |||
44349354 | 125329 | 0 | None | - | 0 | Rat | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 415 | 8 | 3 | 4 | 2.9 | CCc1cccc(C(=O)NC(CCC(=O)O)C(=O)NN2CCC3(CCCC3)CC2)c1 | 10.1021/jm00079a003 | |||
CHEMBL341505 | 125329 | 0 | None | - | 0 | Rat | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 415 | 8 | 3 | 4 | 2.9 | CCc1cccc(C(=O)NC(CCC(=O)O)C(=O)NN2CCC3(CCCC3)CC2)c1 | 10.1021/jm00079a003 | |||
14208267 | 211305 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 380 | 3 | 2 | 4 | 3.1 | N#Cc1ccc(C(=O)NC2N=C(c3ccccc3)c3ccccc3NC2=O)cc1 | 10.1021/jm00047a021 | |||
CHEMBL72710 | 211305 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 380 | 3 | 2 | 4 | 3.1 | N#Cc1ccc(C(=O)NC2N=C(c3ccccc3)c3ccccc3NC2=O)cc1 | 10.1021/jm00047a021 | |||
10350069 | 16745 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 742 | 17 | 7 | 6 | 5.8 | Cc1ccccc1NC(=O)NCCCC[C@@H](CNC(=O)CCC(=O)O)NC(=O)[C@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 | 10.1021/jm00017a022 | |||
CHEMBL114774 | 16745 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 742 | 17 | 7 | 6 | 5.8 | Cc1ccccc1NC(=O)NCCCC[C@@H](CNC(=O)CCC(=O)O)NC(=O)[C@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 | 10.1021/jm00017a022 | |||
44348902 | 162541 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 1000 | 24 | 11 | 11 | 2.3 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1cc(NC(=O)[C@H](Cc2ccc(S(=O)(=O)O)cc2)NC(=O)O)ccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00099a005 | |||
CHEMBL405805 | 162541 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 1000 | 24 | 11 | 11 | 2.3 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1cc(NC(=O)[C@H](Cc2ccc(S(=O)(=O)O)cc2)NC(=O)O)ccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00099a005 | |||
44300862 | 164651 | 0 | None | - | 0 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 695 | 9 | 4 | 6 | 5.2 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)NS(=O)(=O)Cc3ccccc3)c1)C[C@@H]2c1ccccc1 | 10.1016/0960-894X(95)00327-P | |||
CHEMBL408392 | 164651 | 0 | None | - | 0 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 695 | 9 | 4 | 6 | 5.2 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)NS(=O)(=O)Cc3ccccc3)c1)C[C@@H]2c1ccccc1 | 10.1016/0960-894X(95)00327-P | |||
14208267 | 211305 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 380 | 3 | 2 | 4 | 3.1 | N#Cc1ccc(C(=O)NC2N=C(c3ccccc3)c3ccccc3NC2=O)cc1 | 10.1021/jm00120a002 | |||
CHEMBL72710 | 211305 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 380 | 3 | 2 | 4 | 3.1 | N#Cc1ccc(C(=O)NC2N=C(c3ccccc3)c3ccccc3NC2=O)cc1 | 10.1021/jm00120a002 | |||
10761732 | 82721 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 371 | 4 | 3 | 5 | 3.5 | O=C(NNc1nc2ccccc2c(=O)n1-c1ccccc1)Nc1ccccc1 | 10.1021/jm970373j | |||
CHEMBL2051984 | 82721 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 371 | 4 | 3 | 5 | 3.5 | O=C(NNc1nc2ccccc2c(=O)n1-c1ccccc1)Nc1ccccc1 | 10.1021/jm970373j | |||
44349314 | 23339 | 0 | None | - | 0 | Rat | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 402 | 8 | 3 | 3 | 3.5 | CC(C)(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1cc(Cl)cc(Cl)c1 | 10.1021/jm00079a003 | |||
CHEMBL123852 | 23339 | 0 | None | - | 0 | Rat | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 402 | 8 | 3 | 3 | 3.5 | CC(C)(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1cc(Cl)cc(Cl)c1 | 10.1021/jm00079a003 | |||
5311201 | 214174 | 35 | None | 26 | 6 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00032a002 | |||
CHEMBL9387 | 214174 | 35 | None | 26 | 6 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00032a002 | |||
5311201 | 214174 | 35 | None | 26 | 6 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1016/0960-894X(95)00530-0 | |||
CHEMBL9387 | 214174 | 35 | None | 26 | 6 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1016/0960-894X(95)00530-0 | |||
5311201 | 214174 | 35 | None | 26 | 6 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(01)80987-2 | |||
CHEMBL9387 | 214174 | 35 | None | 26 | 6 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(01)80987-2 | |||
5311201 | 214174 | 35 | None | 26 | 6 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm9506736 | |||
CHEMBL9387 | 214174 | 35 | None | 26 | 6 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm9506736 | |||
5311201 | 214174 | 35 | None | 26 | 6 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm9608523 | |||
CHEMBL9387 | 214174 | 35 | None | 26 | 6 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm9608523 | |||
44376130 | 63110 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1ccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc1 | 10.1021/jm00032a003 | |||
CHEMBL163049 | 63110 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1ccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc1 | 10.1021/jm00032a003 | |||
44280599 | 105938 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 694 | 12 | 4 | 5 | 6.2 | O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2ccccc12 | 10.1021/jm950372w | |||
CHEMBL281206 | 105938 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 694 | 12 | 4 | 5 | 6.2 | O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2ccccc12 | 10.1021/jm950372w | |||
5311201 | 214174 | 35 | None | 26 | 6 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm970373j | |||
CHEMBL9387 | 214174 | 35 | None | 26 | 6 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm970373j | |||
14802510 | 121895 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 629 | 13 | 4 | 6 | 5.2 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](COC(=O)CCC(=O)O)Cc1ccccc1 | 10.1021/jm00105a062 | |||
CHEMBL334346 | 121895 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 629 | 13 | 4 | 6 | 5.2 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](COC(=O)CCC(=O)O)Cc1ccccc1 | 10.1021/jm00105a062 | |||
44368298 | 127806 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 613 | 13 | 4 | 5 | 4.8 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)C1C2CC3CC(C2)CC1C3)C(=O)N[C@H](COC(=O)CCC(=O)O)Cc1ccccc1 | 10.1021/jm00057a005 | |||
CHEMBL356599 | 127806 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 613 | 13 | 4 | 5 | 4.8 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)C1C2CC3CC(C2)CC1C3)C(=O)N[C@H](COC(=O)CCC(=O)O)Cc1ccccc1 | 10.1021/jm00057a005 | |||
43811299 | 123438 | 13 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 452 | 3 | 2 | 3 | 4.7 | CN1C(=O)C(NC(=O)Nc2cccc(C(F)(F)F)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL337055 | 123438 | 13 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 452 | 3 | 2 | 3 | 4.7 | CN1C(=O)C(NC(=O)Nc2cccc(C(F)(F)F)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
5311201 | 214174 | 35 | None | 26 | 6 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00078a018 | |||
CHEMBL9387 | 214174 | 35 | None | 26 | 6 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00078a018 | |||
44281205 | 121596 | 0 | None | - | 1 | Mouse | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 857 | 17 | 4 | 10 | 5.1 | CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCCN3CCN(C(=O)CNCCCOc4cccc(CN5CCCCC5)c4)CC3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00249-1 | |||
CHEMBL33412 | 121596 | 0 | None | - | 1 | Mouse | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 857 | 17 | 4 | 10 | 5.1 | CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCCN3CCN(C(=O)CNCCCOc4cccc(CN5CCCCC5)c4)CC3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00249-1 | |||
90663256 | 113407 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 854 | 17 | 7 | 8 | 5.3 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N1CSC(C)(C)[C@H]1C(=O)NC(Cc1ccccc1)C(N)=O | 10.1021/jm00100a033 | |||
CHEMBL3143146 | 113407 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 854 | 17 | 7 | 8 | 5.3 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N1CSC(C)(C)[C@H]1C(=O)NC(Cc1ccccc1)C(N)=O | 10.1021/jm00100a033 | |||
CHEMBL2372080 | 216965 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H]1CNC(=O)CNC(=O)[C@H](CNCc2ccccc2)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1016/j.bmc.2007.05.067 | |||||
10504136 | 213417 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 459 | 7 | 3 | 7 | 4.3 | COc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(OC(C)C)c2)c1 | 10.1021/jm970373j | |||
CHEMBL8922 | 213417 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 459 | 7 | 3 | 7 | 4.3 | COc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(OC(C)C)c2)c1 | 10.1021/jm970373j | |||
44286835 | 107061 | 0 | None | - | 0 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 796 | 20 | 8 | 7 | 4.5 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)NCCCC(=O)NC(Cc1ccccc1)C(N)=O | 10.1021/jm00037a005 | |||
CHEMBL289036 | 107061 | 0 | None | - | 0 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 796 | 20 | 8 | 7 | 4.5 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)NCCCC(=O)NC(Cc1ccccc1)C(N)=O | 10.1021/jm00037a005 | |||
9916170 | 83328 | 3 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 575 | 10 | 4 | 4 | 5.4 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CC(=O)O)Cc1ccc(F)cc1 | 10.1016/s0960-894x(00)00198-0 | |||
CHEMBL2062146 | 83328 | 3 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 575 | 10 | 4 | 4 | 5.4 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CC(=O)O)Cc1ccc(F)cc1 | 10.1016/s0960-894x(00)00198-0 | |||
10462874 | 105612 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 766 | 16 | 6 | 5 | 7.1 | O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1)NCCCCNC(=O)Nc1ccccc1Cl | 10.1016/S0960-894X(00)80687-3 | |||
CHEMBL278780 | 105612 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 766 | 16 | 6 | 5 | 7.1 | O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1)NCCCCNC(=O)Nc1ccccc1Cl | 10.1016/S0960-894X(00)80687-3 | |||
10074366 | 127376 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 491 | 9 | 4 | 4 | 4.5 | C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
CHEMBL3349028 | 127376 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 491 | 9 | 4 | 4 | 4.5 | C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
CHEMBL3545866 | 127376 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 491 | 9 | 4 | 4 | 4.5 | C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
10031013 | 213263 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 574 | 8 | 1 | 4 | 6.2 | CC(C)N(C(=O)CN1C(=O)C(C)(CC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1021/jm960249k | |||
CHEMBL88239 | 213263 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 574 | 8 | 1 | 4 | 6.2 | CC(C)N(C(=O)CN1C(=O)C(C)(CC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1021/jm960249k | |||
10031013 | 213263 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 574 | 8 | 1 | 4 | 6.2 | CC(C)N(C(=O)CN1C(=O)C(C)(CC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1021/jm960205b | |||
CHEMBL88239 | 213263 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 574 | 8 | 1 | 4 | 6.2 | CC(C)N(C(=O)CN1C(=O)C(C)(CC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1021/jm960205b | |||
10031013 | 213263 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 574 | 8 | 1 | 4 | 6.2 | CC(C)N(C(=O)CN1C(=O)C(C)(CC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1021/acs.jmedchem.0c00829 | |||
CHEMBL88239 | 213263 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 574 | 8 | 1 | 4 | 6.2 | CC(C)N(C(=O)CN1C(=O)C(C)(CC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1021/acs.jmedchem.0c00829 | |||
44286655 | 106632 | 0 | None | - | 0 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 808 | 16 | 6 | 7 | 4.5 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N1CCC(=O)N(C(Cc2ccccc2)C(N)=O)CC1 | 10.1021/jm00037a005 | |||
CHEMBL285772 | 106632 | 0 | None | - | 0 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 808 | 16 | 6 | 7 | 4.5 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N1CCC(=O)N(C(Cc2ccccc2)C(N)=O)CC1 | 10.1021/jm00037a005 | |||
44329384 | 215110 | 0 | None | - | 0 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 556 | 7 | 3 | 4 | 5.6 | COc1ccccc1[C@H]1C[C@@H](NC(=O)Nc2cccc(C)c2)C(=O)N(CC(=O)NC(C)(C)C)[C@@H](c2ccccc2)C1 | 10.1016/S0960-894X(01)80832-5 | |||
CHEMBL99289 | 215110 | 0 | None | - | 0 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 556 | 7 | 3 | 4 | 5.6 | COc1ccccc1[C@H]1C[C@@H](NC(=O)Nc2cccc(C)c2)C(=O)N(CC(=O)NC(C)(C)C)[C@@H](c2ccccc2)C1 | 10.1016/S0960-894X(01)80832-5 | |||
89913304 | 147549 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 249 | 2 | 1 | 2 | 2.0 | O=C1C=C(Cl)C(O)(c2ccccc2)N1C1CC1 | 10.1039/C6MD00052E | |||
CHEMBL3818437 | 147549 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 249 | 2 | 1 | 2 | 2.0 | O=C1C=C(Cl)C(O)(c2ccccc2)N1C1CC1 | 10.1039/C6MD00052E | |||
5279123 | 211320 | 1 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 389 | 3 | 2 | 3 | 3.9 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccccc1Cl | 10.1021/jm00120a002 | |||
CHEMBL72841 | 211320 | 1 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 389 | 3 | 2 | 3 | 3.9 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccccc1Cl | 10.1021/jm00120a002 | |||
15614763 | 74540 | 0 | None | - | 0 | Rat | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 401 | 3 | 3 | 2 | 5.1 | O=C1Nc2ccc(Cl)cc2C(c2ccccc2)N[C@H]1Cc1c[nH]c2ccccc12 | 10.1021/jm00390a019 | |||
CHEMBL1907932 | 74540 | 0 | None | - | 0 | Rat | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 401 | 3 | 3 | 2 | 5.1 | O=C1Nc2ccc(Cl)cc2C(c2ccccc2)N[C@H]1Cc1c[nH]c2ccccc12 | 10.1021/jm00390a019 | |||
5279123 | 211320 | 1 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 389 | 3 | 2 | 3 | 3.9 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccccc1Cl | 10.1021/jm00047a021 | |||
CHEMBL72841 | 211320 | 1 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 389 | 3 | 2 | 3 | 3.9 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccccc1Cl | 10.1021/jm00047a021 | |||
14991538 | 113603 | 0 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 921 | 24 | 9 | 11 | 2.4 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
CHEMBL3144566 | 113603 | 0 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 921 | 24 | 9 | 11 | 2.4 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
52949124 | 7663 | 4 | None | - | 2 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
9055 | 7663 | 4 | None | - | 2 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
CHEMBL1269258 | 7663 | 4 | None | - | 2 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
DB12694 | 7663 | 4 | None | - | 2 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
10481933 | 20068 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 524 | 5 | 2 | 5 | 3.1 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)N3CCN(C)CC3)C2=O)c1 | 10.1021/jm00078a018 | |||
CHEMBL1191818 | 20068 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 524 | 5 | 2 | 5 | 3.1 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)N3CCN(C)CC3)C2=O)c1 | 10.1021/jm00078a018 | |||
CHEMBL542967 | 20068 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 524 | 5 | 2 | 5 | 3.1 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)N3CCN(C)CC3)C2=O)c1 | 10.1021/jm00078a018 | |||
44279808 | 105917 | 0 | None | - | 1 | Mouse | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 712 | 13 | 6 | 9 | 2.9 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCC(=O)NCCSCc3csc(N=C(N)N)n3)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
CHEMBL281082 | 105917 | 0 | None | - | 1 | Mouse | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 712 | 13 | 6 | 9 | 2.9 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCC(=O)NCCSCc3csc(N=C(N)N)n3)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
10369804 | 23532 | 0 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 532 | 5 | 3 | 3 | 5.6 | Cc1cccc2c1N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2c1ccccc1 | 10.1021/jm00048a015 | |||
CHEMBL124340 | 23532 | 0 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 532 | 5 | 3 | 3 | 5.6 | Cc1cccc2c1N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2c1ccccc1 | 10.1021/jm00048a015 | |||
9984452 | 172082 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 529 | 9 | 4 | 4 | 4.7 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
CHEMBL423329 | 172082 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 529 | 9 | 4 | 4 | 4.7 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
44283055 | 123390 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 515 | 9 | 4 | 4 | 4.4 | O=C(NC(Cc1c[nH]c2ccccc12)C(=O)NC(CO)Cc1ccccc1)OC1C2CC3CC(C2)CC1C3 | 10.1016/S0960-894X(00)80156-0 | |||
CHEMBL336769 | 123390 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 515 | 9 | 4 | 4 | 4.4 | O=C(NC(Cc1c[nH]c2ccccc12)C(=O)NC(CO)Cc1ccccc1)OC1C2CC3CC(C2)CC1C3 | 10.1016/S0960-894X(00)80156-0 | |||
14208282 | 74460 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 363 | 5 | 1 | 3 | 3.4 | CC(C)CCC(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2N(C)C1=O | 10.1021/jm00120a002 | |||
CHEMBL1907663 | 74460 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 363 | 5 | 1 | 3 | 3.4 | CC(C)CCC(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2N(C)C1=O | 10.1021/jm00120a002 | |||
9984452 | 172082 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 529 | 9 | 4 | 4 | 4.7 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00105a062 | |||
CHEMBL423329 | 172082 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 529 | 9 | 4 | 4 | 4.7 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00105a062 | |||
15177358 52940604 | 23302 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 667 | 9 | 4 | 4 | 7.1 | ClC(Cl)(Cl)Cl.O=C(NC(Cc1c[nH]c2ccccc12)NC(=O)C(CO)Cc1ccccc1)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1021/jm00086a017 | |||
CHEMBL1237153 | 23302 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 667 | 9 | 4 | 4 | 7.1 | ClC(Cl)(Cl)Cl.O=C(NC(Cc1c[nH]c2ccccc12)NC(=O)C(CO)Cc1ccccc1)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1021/jm00086a017 | |||
44368624 | 127911 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 513 | 9 | 4 | 3 | 4.4 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)C1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
CHEMBL357564 | 127911 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 513 | 9 | 4 | 3 | 4.4 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)C1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
9984452 | 36487 | 0 | None | - | 1 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 529 | 9 | 4 | 4 | 4.7 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm970065l | |||
CHEMBL138657 | 36487 | 0 | None | - | 1 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 529 | 9 | 4 | 4 | 4.7 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm970065l | |||
44368329 | 127781 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 499 | 8 | 3 | 3 | 5.5 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC12C[C@H]3C[C@@H](C1)C[C@@H](C2)C3)C(=O)NCCc1ccccc1 | 10.1021/jm00057a005 | |||
CHEMBL356446 | 127781 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 499 | 8 | 3 | 3 | 5.5 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC12C[C@H]3C[C@@H](C1)C[C@@H](C2)C3)C(=O)NCCc1ccccc1 | 10.1021/jm00057a005 | |||
10483574 | 12978 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 591 | 8 | 2 | 5 | 5.3 | COc1ccc(N(C(=O)CN2C(=O)C(NC(=O)Nc3ccccc3)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm950626d | |||
CHEMBL108130 | 12978 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 591 | 8 | 2 | 5 | 5.3 | COc1ccc(N(C(=O)CN2C(=O)C(NC(=O)Nc3ccccc3)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm950626d | |||
73351320 | 112923 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 681 | 12 | 5 | 5 | 5.1 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCNC(=O)C(F)(F)F)c1ccccc1 | 10.1021/jm00092a007 | |||
CHEMBL313559 | 112923 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 681 | 12 | 5 | 5 | 5.1 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCNC(=O)C(F)(F)F)c1ccccc1 | 10.1021/jm00092a007 | |||
6439414 | 9799 | 14 | None | -2454 | 2 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 612 | 11 | 5 | 5 | 4.6 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)/C=C/C(=O)O | 10.1021/jm00105a062 | |||
867 | 9799 | 14 | None | -2454 | 2 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 612 | 11 | 5 | 5 | 4.6 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)/C=C/C(=O)O | 10.1021/jm00105a062 | |||
CHEMBL3351022 | 9799 | 14 | None | -2454 | 2 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 612 | 11 | 5 | 5 | 4.6 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)/C=C/C(=O)O | 10.1021/jm00105a062 | |||
CHEMBL341460 | 9799 | 14 | None | -2454 | 2 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 612 | 11 | 5 | 5 | 4.6 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)/C=C/C(=O)O | 10.1021/jm00105a062 | |||
44368728 | 126284 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 596 | 11 | 5 | 4 | 4.3 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)C1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)/C=C/C(=O)O)c1ccccc1 | 10.1021/jm00057a005 | |||
CHEMBL345512 | 126284 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 596 | 11 | 5 | 4 | 4.3 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)C1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)/C=C/C(=O)O)c1ccccc1 | 10.1021/jm00057a005 | |||
14208306 | 210966 | 1 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 513 | 3 | 1 | 3 | 4.0 | CN1C(=O)C(NC(=O)c2ccccc2I)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00047a021 | |||
CHEMBL70791 | 210966 | 1 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 513 | 3 | 1 | 3 | 4.0 | CN1C(=O)C(NC(=O)c2ccccc2I)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00047a021 | |||
44451577 | 102560 | 0 | None | - | 0 | Mouse | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 546 | 6 | 2 | 5 | 2.1 | Cc1cccc(NC(=O)NC2C(=O)N(CC(=O)N3CCCC3)c3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 | 10.1016/j.bmc.2007.12.047 | |||
CHEMBL258630 | 102560 | 0 | None | - | 0 | Mouse | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 546 | 6 | 2 | 5 | 2.1 | Cc1cccc(NC(=O)NC2C(=O)N(CC(=O)N3CCCC3)c3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 | 10.1016/j.bmc.2007.12.047 | |||
52949124 | 7663 | 4 | None | -2 | 2 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
9055 | 7663 | 4 | None | -2 | 2 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
CHEMBL1269258 | 7663 | 4 | None | -2 | 2 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
DB12694 | 7663 | 4 | None | -2 | 2 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
46235271 | 80423 | 2 | None | 2 | 2 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 649 | 7 | 1 | 6 | 6.7 | Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1021/acs.jmedchem.5b01110 | |||
CHEMBL2017835 | 80423 | 2 | None | 2 | 2 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 649 | 7 | 1 | 6 | 6.7 | Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1021/acs.jmedchem.5b01110 | |||
15689723 | 113372 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 880 | 20 | 9 | 8 | 4.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1C(F)(F)F)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||
CHEMBL3142693 | 113372 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 880 | 20 | 9 | 8 | 4.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1C(F)(F)F)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||
89913313 | 147568 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 299 | 3 | 1 | 2 | 3.1 | CC(C)CN1C(=O)C=C(Cl)C1(O)c1ccc(Cl)cc1 | 10.1039/C6MD00052E | |||
CHEMBL3818718 | 147568 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 299 | 3 | 1 | 2 | 3.1 | CC(C)CN1C(=O)C=C(Cl)C1(O)c1ccc(Cl)cc1 | 10.1039/C6MD00052E | |||
443375 | 214385 | 45 | None | -3 | 5 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00163a069 | |||
CHEMBL9506 | 214385 | 45 | None | -3 | 5 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00163a069 | |||
44578305 | 187949 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 520 | 5 | 0 | 5 | 6.1 | COc1cccc(-n2cc(C(=O)N3CCN(c4ccc(Cl)c(Cl)c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
CHEMBL476095 | 187949 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 520 | 5 | 0 | 5 | 6.1 | COc1cccc(-n2cc(C(=O)N3CCN(c4ccc(Cl)c(Cl)c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
14991571 | 209715 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 905 | 21 | 8 | 10 | 3.9 | CC(=O)Oc1ccc2cc(C(=O)NCCCC[C@H](NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc3ccccc3)C(N)=O)ccc2c1 | 10.1021/jm00089a010 | |||
CHEMBL62887 | 209715 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 905 | 21 | 8 | 10 | 3.9 | CC(=O)Oc1ccc2cc(C(=O)NCCCC[C@H](NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc3ccccc3)C(N)=O)ccc2c1 | 10.1021/jm00089a010 | |||
104929 | 9000 | 9 | None | - | 3 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 | 10.1021/jm00121a004 | |||
3477 | 9000 | 9 | None | - | 3 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 | 10.1021/jm00121a004 | |||
879 | 9000 | 9 | None | - | 3 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 | 10.1021/jm00121a004 | |||
CHEMBL289498 | 9000 | 9 | None | - | 3 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 | 10.1021/jm00121a004 | |||
10009894 | 32400 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 694 | 13 | 6 | 6 | 4.9 | Cc1ccccc1NC(=O)NCCCC[C@@H](CC(=O)O)NC(=O)[C@H]1Cc2c([nH]c3ccccc23)[C@@H]2C[C@@H](NC(=O)OCc3ccccc3)C(=O)N21 | 10.1016/s0960-894x(01)00630-8 | |||
CHEMBL13517 | 32400 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 694 | 13 | 6 | 6 | 4.9 | Cc1ccccc1NC(=O)NCCCC[C@@H](CC(=O)O)NC(=O)[C@H]1Cc2c([nH]c3ccccc23)[C@@H]2C[C@@H](NC(=O)OCc3ccccc3)C(=O)N21 | 10.1016/s0960-894x(01)00630-8 | |||
10070679 | 34541 | 13 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 418 | 3 | 2 | 3 | 4.3 | CN1C(=O)C(NC(=O)Nc2cccc(Cl)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL137066 | 34541 | 13 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 418 | 3 | 2 | 3 | 4.3 | CN1C(=O)C(NC(=O)Nc2cccc(Cl)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL407530 | 219446 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00100a033 | |||||
14208194 | 170215 | 2 | None | 1122 | 2 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm000937a | |||
CHEMBL419764 | 170215 | 2 | None | 1122 | 2 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm000937a | |||
14208243 | 211196 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 403 | 3 | 1 | 3 | 3.9 | CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL72073 | 211196 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 403 | 3 | 1 | 3 | 3.9 | CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
14208194 | 170215 | 2 | None | 1122 | 2 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL419764 | 170215 | 2 | None | 1122 | 2 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
10452597 | 33699 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 384 | 3 | 2 | 3 | 3.6 | CN1C(=O)C(NC(=O)Nc2ccccc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL136408 | 33699 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 384 | 3 | 2 | 3 | 3.6 | CN1C(=O)C(NC(=O)Nc2ccccc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
14208243 | 211196 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 403 | 3 | 1 | 3 | 3.9 | CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(00)80682-4 | |||
CHEMBL72073 | 211196 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 403 | 3 | 1 | 3 | 3.9 | CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(00)80682-4 | |||
14208194 | 170215 | 2 | None | 1122 | 2 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(00)80684-8 | |||
CHEMBL419764 | 170215 | 2 | None | 1122 | 2 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(00)80684-8 | |||
14208243 | 211196 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 403 | 3 | 1 | 3 | 3.9 | CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00047a021 | |||
CHEMBL72073 | 211196 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 403 | 3 | 1 | 3 | 3.9 | CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00047a021 | |||
10817395 | 113919 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 600 | 8 | 1 | 4 | 6.9 | COc1ccc(N(C(=O)CN2C(=O)C(C)(Cc3c[nH]c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm960249k | |||
CHEMBL316164 | 113919 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 600 | 8 | 1 | 4 | 6.9 | COc1ccc(N(C(=O)CN2C(=O)C(C)(Cc3c[nH]c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm960249k | |||
10817395 | 113919 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 600 | 8 | 1 | 4 | 6.9 | COc1ccc(N(C(=O)CN2C(=O)C(C)(Cc3c[nH]c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm970265x | |||
CHEMBL316164 | 113919 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 600 | 8 | 1 | 4 | 6.9 | COc1ccc(N(C(=O)CN2C(=O)C(C)(Cc3c[nH]c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm970265x | |||
15689727 | 113370 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 880 | 20 | 9 | 8 | 4.6 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccc(Cl)cc1Cl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||
CHEMBL3142690 | 113370 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 880 | 20 | 9 | 8 | 4.6 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccc(Cl)cc1Cl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||
44578455 | 189234 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 503 | 5 | 0 | 6 | 5.4 | COc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ncccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
CHEMBL478630 | 189234 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 503 | 5 | 0 | 6 | 5.4 | COc1cccc(-n2cc(C(=O)N3CCN(c4ccc5ncccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
10480792 | 52574 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 491 | 9 | 4 | 4 | 4.5 | CC1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
CHEMBL153095 | 52574 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 491 | 9 | 4 | 4 | 4.5 | CC1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
CHEMBL3350686 | 52574 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 491 | 9 | 4 | 4 | 4.5 | CC1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
14208210 | 210982 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 413 | 3 | 2 | 4 | 4.1 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1cc2ccccc2o1 | 10.1021/jm00047a021 | |||
CHEMBL70856 | 210982 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 413 | 3 | 2 | 4 | 4.1 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1cc2ccccc2o1 | 10.1021/jm00047a021 | |||
21842365 | 126532 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 495 | 6 | 2 | 5 | 4.5 | Cc1cccc(NC(=O)NC2N=C(c3cccnc3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 | 10.1016/0960-894X(95)00557-A | |||
CHEMBL347843 | 126532 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 495 | 6 | 2 | 5 | 4.5 | Cc1cccc(NC(=O)NC2N=C(c3cccnc3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 | 10.1016/0960-894X(95)00557-A | |||
11765257 | 115609 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 695 | 10 | 2 | 6 | 6.6 | COc1ccc(N(C(=O)CN2C(=O)C(NC(=O)Nc3cccc(C(=O)c4ccccc4)c3)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1016/s0960-894x(98)00548-4 | |||
CHEMBL320980 | 115609 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 695 | 10 | 2 | 6 | 6.6 | COc1ccc(N(C(=O)CN2C(=O)C(NC(=O)Nc3cccc(C(=O)c4ccccc4)c3)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1016/s0960-894x(98)00548-4 | |||
46234820 | 80414 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 572 | 6 | 1 | 5 | 6.1 | CC(C)C1CCCCN1C(=O)CN1C(=O)C(Cc2c[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc21 | 10.1016/j.bmcl.2012.02.049 | |||
CHEMBL2017826 | 80414 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 572 | 6 | 1 | 5 | 6.1 | CC(C)C1CCCCN1C(=O)CN1C(=O)C(Cc2c[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc21 | 10.1016/j.bmcl.2012.02.049 | |||
CHEMBL328422 | 218075 | 0 | None | - | 0 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | None | None | None | Cc1cccc(C)c1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||||
89913684 | 147547 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 299 | 3 | 1 | 2 | 3.0 | O=C1C=C(Cl)C(O)(c2ccccc2)N1Cc1ccccc1 | 10.1039/C6MD00052E | |||
CHEMBL3818410 | 147547 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 299 | 3 | 1 | 2 | 3.0 | O=C1C=C(Cl)C(O)(c2ccccc2)N1Cc1ccccc1 | 10.1039/C6MD00052E | |||
14208307 | 84599 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 513 | 3 | 1 | 3 | 4.0 | CN1C(=O)[C@@H](NC(=O)c2ccccc2I)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL2092867 | 84599 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 513 | 3 | 1 | 3 | 4.0 | CN1C(=O)[C@@H](NC(=O)c2ccccc2I)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
14208283 | 74459 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 375 | 3 | 1 | 3 | 3.5 | CN1C(=O)[C@@H](NC(=O)C2CCCCC2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL1907662 | 74459 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 375 | 3 | 1 | 3 | 3.5 | CN1C(=O)[C@@H](NC(=O)C2CCCCC2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
20190197 | 38293 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 421 | 4 | 1 | 3 | 4.6 | CN1c2ccccc2C(c2ccccc2F)=NCC1CNC(=O)c1ccc(Cl)cc1 | 10.1021/jm00163a069 | |||
CHEMBL140365 | 38293 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 421 | 4 | 1 | 3 | 4.6 | CN1c2ccccc2C(c2ccccc2F)=NCC1CNC(=O)c1ccc(Cl)cc1 | 10.1021/jm00163a069 | |||
10075052 | 196453 | 0 | None | - | 2 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 510 | 3 | 2 | 3 | 4.3 | CN1C(=O)[C@H](NC(=O)Nc2cccc(I)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL515268 | 196453 | 0 | None | - | 2 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 510 | 3 | 2 | 3 | 4.3 | CN1C(=O)[C@H](NC(=O)Nc2cccc(I)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL515288 | 196453 | 0 | None | - | 2 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 510 | 3 | 2 | 3 | 4.3 | CN1C(=O)[C@H](NC(=O)Nc2cccc(I)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
44334320 | 11795 | 0 | None | - | 0 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 531 | 9 | 2 | 4 | 4.6 | Cc1cccc(NC(=O)N[C@H](C[S+]([O-])Cc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
CHEMBL105132 | 11795 | 0 | None | - | 0 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 531 | 9 | 2 | 4 | 4.6 | Cc1cccc(NC(=O)N[C@H](C[S+]([O-])Cc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
15673150 | 92769 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 681 | 12 | 5 | 5 | 5.1 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCNC(=O)C(F)(F)F)c1ccccc1 | 10.1016/S0960-894X(00)80652-6 | |||
CHEMBL2304154 | 92769 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 681 | 12 | 5 | 5 | 5.1 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCNC(=O)C(F)(F)F)c1ccccc1 | 10.1016/S0960-894X(00)80652-6 | |||
44349413 | 119884 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 410 | 12 | 3 | 3 | 4.0 | CCC(CC)(CC)CCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 | 10.1021/jm00079a003 | |||
CHEMBL331413 | 119884 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 410 | 12 | 3 | 3 | 4.0 | CCC(CC)(CC)CCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 | 10.1021/jm00079a003 | |||
44360216 | 39006 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 403 | 5 | 3 | 4 | 3.3 | O=C(NCC1CNc2ccccc2C(c2ccccc2F)=N1)C(O)c1ccccc1 | 10.1021/jm00163a069 | |||
CHEMBL140974 | 39006 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 403 | 5 | 3 | 4 | 3.3 | O=C(NCC1CNc2ccccc2C(c2ccccc2F)=N1)C(O)c1ccccc1 | 10.1021/jm00163a069 | |||
44349240 | 124895 | 0 | None | - | 0 | Rat | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 368 | 11 | 3 | 3 | 3.0 | CCCCCCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 | 10.1021/jm00079a003 | |||
CHEMBL340755 | 124895 | 0 | None | - | 0 | Rat | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 368 | 11 | 3 | 3 | 3.0 | CCCCCCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 | 10.1021/jm00079a003 | |||
9800177 | 74483 | 0 | None | - | 0 | Guinea pig | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 383 | 3 | 2 | 2 | 4.7 | O=C1Nc2ccccc2C(c2ccccc2F)=N[C@@H]1Cc1c[nH]c2ccccc12 | 10.1021/jm00390a019 | |||
CHEMBL1907714 | 74483 | 0 | None | - | 0 | Guinea pig | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 383 | 3 | 2 | 2 | 4.7 | O=C1Nc2ccccc2C(c2ccccc2F)=N[C@@H]1Cc1c[nH]c2ccccc12 | 10.1021/jm00390a019 | |||
15614841 | 74495 | 0 | None | - | 0 | Guinea pig | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 390 | 5 | 1 | 3 | 4.7 | O=C1Nc2ccc(Cl)cc2C(c2ccccc2)=N[C@@H]1COCc1ccccc1 | 10.1021/jm00390a019 | |||
CHEMBL1907734 | 74495 | 0 | None | - | 0 | Guinea pig | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 390 | 5 | 1 | 3 | 4.7 | O=C1Nc2ccc(Cl)cc2C(c2ccccc2)=N[C@@H]1COCc1ccccc1 | 10.1021/jm00390a019 | |||
CHEMBL286843 | 106798 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 541 | 8 | 3 | 4 | 7.2 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C1NC=C(CCc2ccccc2)S1 | 10.1021/jm00086a017 | |||
10480605 | 85135 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 487 | 5 | 4 | 7 | 3.7 | Cc1ccc(NC(=O)N[C@@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)cc1Nc1nn[nH]n1 | 10.1021/jm9506736 | |||
CHEMBL2110201 | 85135 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 487 | 5 | 4 | 7 | 3.7 | Cc1ccc(NC(=O)N[C@@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)cc1Nc1nn[nH]n1 | 10.1021/jm9506736 | |||
44349411 | 23615 | 0 | None | - | 0 | Rat | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 380 | 7 | 3 | 3 | 3.1 | O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NC1CCCCCC1 | 10.1021/jm00079a003 | |||
CHEMBL124802 | 23615 | 0 | None | - | 0 | Rat | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 380 | 7 | 3 | 3 | 3.1 | O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NC1CCCCCC1 | 10.1021/jm00079a003 | |||
44283159 | 106910 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 515 | 8 | 3 | 3 | 6.6 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)/C(S)=N/CCc1ccccc1 | 10.1021/jm00086a017 | |||
CHEMBL287682 | 106910 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 515 | 8 | 3 | 3 | 6.6 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)/C(S)=N/CCc1ccccc1 | 10.1021/jm00086a017 | |||
44331065 | 114003 | 0 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 974 | 25 | 8 | 11 | 1.3 | CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00094a001 | |||
CHEMBL316709 | 114003 | 0 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 974 | 25 | 8 | 11 | 1.3 | CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00094a001 | |||
15667015 | 168633 | 0 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 990 | 29 | 10 | 11 | 2.0 | CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00094a001 | |||
CHEMBL414793 | 168633 | 0 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 990 | 29 | 10 | 11 | 2.0 | CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00094a001 | |||
14208253 | 211488 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 389 | 3 | 2 | 3 | 3.9 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1cccc(Cl)c1 | 10.1021/jm00120a002 | |||
CHEMBL74125 | 211488 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 389 | 3 | 2 | 3 | 3.9 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1cccc(Cl)c1 | 10.1021/jm00120a002 | |||
14208253 | 211488 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 389 | 3 | 2 | 3 | 3.9 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1cccc(Cl)c1 | 10.1021/jm00047a021 | |||
CHEMBL74125 | 211488 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 389 | 3 | 2 | 3 | 3.9 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1cccc(Cl)c1 | 10.1021/jm00047a021 | |||
14802508 | 85566 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 615 | 12 | 4 | 6 | 5.3 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCC(OC(=O)CCC(=O)O)c1ccccc1 | 10.1021/jm00105a062 | |||
CHEMBL2112695 | 85566 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 615 | 12 | 4 | 6 | 5.3 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCC(OC(=O)CCC(=O)O)c1ccccc1 | 10.1021/jm00105a062 | |||
15104629 | 116896 | 0 | None | - | 0 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 462 | 7 | 3 | 3 | 4.9 | C[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cnc2ccccc2c1)c1ccccc1 | 10.1021/jm00116a002 | |||
CHEMBL323627 | 116896 | 0 | None | - | 0 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 462 | 7 | 3 | 3 | 4.9 | C[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cnc2ccccc2c1)c1ccccc1 | 10.1021/jm00116a002 | |||
14720386 | 55098 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 463 | 12 | 2 | 4 | 4.4 | CCCN(CCC)C(=O)[C@H](CCC(=O)OCc1ccccc1)NC(=O)c1cc2ccccc2[nH]1 | 10.1021/jm00164a020 | |||
CHEMBL155406 | 55098 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 463 | 12 | 2 | 4 | 4.4 | CCCN(CCC)C(=O)[C@H](CCC(=O)OCc1ccccc1)NC(=O)c1cc2ccccc2[nH]1 | 10.1021/jm00164a020 | |||
44329055 | 214743 | 0 | None | - | 0 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 554 | 7 | 3 | 3 | 6.1 | CCc1ccccc1[C@H]1C[C@@H](NC(=O)Nc2cccc(C)c2)C(=O)N(CC(=O)NC(C)(C)C)[C@@H](c2ccccc2)C1 | 10.1016/S0960-894X(01)80832-5 | |||
CHEMBL97133 | 214743 | 0 | None | - | 0 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 554 | 7 | 3 | 3 | 6.1 | CCc1ccccc1[C@H]1C[C@@H](NC(=O)Nc2cccc(C)c2)C(=O)N(CC(=O)NC(C)(C)C)[C@@H](c2ccccc2)C1 | 10.1016/S0960-894X(01)80832-5 | |||
44382706 | 65794 | 2 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 475 | 3 | 2 | 2 | 5.9 | O=C1NN(C(=S)Nc2ccc(Cl)c(C(F)(F)F)c2)[C@@H](c2ccccc2)[C@@H]1c1ccccc1 | 10.1016/S0960-894X(00)80684-8 | |||
CHEMBL169274 | 65794 | 2 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 475 | 3 | 2 | 2 | 5.9 | O=C1NN(C(=S)Nc2ccc(Cl)c(C(F)(F)F)c2)[C@@H](c2ccccc2)[C@@H]1c1ccccc1 | 10.1016/S0960-894X(00)80684-8 | |||
11667741 | 203361 | 0 | None | - | 2 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 366 | 4 | 1 | 5 | 2.5 | Cc1c(CC(=O)O)c2cccnc2n1S(=O)(=O)c1ccc(F)c(F)c1 | 10.1016/j.bmcl.2009.06.042 | |||
CHEMBL563949 | 203361 | 0 | None | - | 2 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 366 | 4 | 1 | 5 | 2.5 | Cc1c(CC(=O)O)c2cccnc2n1S(=O)(=O)c1ccc(F)c(F)c1 | 10.1016/j.bmcl.2009.06.042 | |||
10528465 | 103825 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 473 | 7 | 4 | 7 | 4.0 | CC(C)Oc1cccc(-n2c(NNC(=O)Nc3cccc(C(=O)O)c3)nc3ccccc3c2=O)c1 | 10.1021/jm970373j | |||
CHEMBL267023 | 103825 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 473 | 7 | 4 | 7 | 4.0 | CC(C)Oc1cccc(-n2c(NNC(=O)Nc3cccc(C(=O)O)c3)nc3ccccc3c2=O)c1 | 10.1021/jm970373j | |||
CHEMBL2369769 | 216464 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | None | None | None | C/C=C/CC[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/0960-894X(94)85022-4 | |||||
11700447 | 79799 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 717 | 10 | 6 | 6 | 3.7 | CC(C)(C)OC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1C[C@@H]2c3[nH]c4ccccc4c3C[C@@H](C(=O)N[C@@H](Cc3ccccc3)C(N)=O)N2C1=O | 10.1021/jm050689o | |||
CHEMBL200953 | 79799 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 717 | 10 | 6 | 6 | 3.7 | CC(C)(C)OC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1C[C@@H]2c3[nH]c4ccccc4c3C[C@@H](C(=O)N[C@@H](Cc3ccccc3)C(N)=O)N2C1=O | 10.1021/jm050689o | |||
13953716 | 108374 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 442 | 3 | 2 | 5 | 4.9 | Cc1nnc2n1-c1ccccc1C(c1ccccc1)=NC2NC(=O)Nc1ccc(Cl)cc1 | 10.1021/jm00396a028 | |||
CHEMBL298705 | 108374 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 442 | 3 | 2 | 5 | 4.9 | Cc1nnc2n1-c1ccccc1C(c1ccccc1)=NC2NC(=O)Nc1ccc(Cl)cc1 | 10.1021/jm00396a028 | |||
44281292 | 121572 | 0 | None | - | 1 | Mouse | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 816 | 17 | 5 | 9 | 5.0 | CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCCNC(=O)CC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00249-1 | |||
CHEMBL33398 | 121572 | 0 | None | - | 1 | Mouse | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 816 | 17 | 5 | 9 | 5.0 | CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCCNC(=O)CC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00249-1 | |||
44329456 | 118222 | 0 | None | - | 0 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 526 | 6 | 3 | 3 | 5.5 | Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)C[C@H](c3ccccc3)N(CC(=O)NC(C)(C)C)C2=O)c1 | 10.1016/S0960-894X(01)80832-5 | |||
CHEMBL327526 | 118222 | 0 | None | - | 0 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 526 | 6 | 3 | 3 | 5.5 | Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)C[C@H](c3ccccc3)N(CC(=O)NC(C)(C)C)C2=O)c1 | 10.1016/S0960-894X(01)80832-5 | |||
10995425 | 122235 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 575 | 7 | 3 | 5 | 4.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=S)N(Cc3ccccc3)C(=O)C[C@H]12 | 10.1021/jm010898i | |||
CHEMBL3350859 | 122235 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 575 | 7 | 3 | 5 | 4.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=S)N(Cc3ccccc3)C(=O)C[C@H]12 | 10.1021/jm010898i | |||
44592486 | 194606 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 393 | 7 | 4 | 3 | 3.6 | CC(C)CC(NC(=O)c1ccccc1NC(=O)c1cc2ccccc2[nH]1)C(=O)O | 10.1016/j.bmc.2009.02.012 | |||
CHEMBL496067 | 194606 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 393 | 7 | 4 | 3 | 3.6 | CC(C)CC(NC(=O)c1ccccc1NC(=O)c1cc2ccccc2[nH]1)C(=O)O | 10.1016/j.bmc.2009.02.012 | |||
155557285 | 181297 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 1779 | 74 | 19 | 22 | 1.6 | CCCC[C@H](NC(=O)[C@H](CNC(=O)CCCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL4555341 | 181297 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 1779 | 74 | 19 | 22 | 1.6 | CCCC[C@H](NC(=O)[C@H](CNC(=O)CCCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
44373702 | 126704 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 555 | 8 | 4 | 4 | 5.1 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@]1(C(=O)O)C[C@H]1c1ccccc1 | 10.1016/S0960-894X(01)81250-6 | |||
CHEMBL349473 | 126704 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 555 | 8 | 4 | 4 | 5.1 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@]1(C(=O)O)C[C@H]1c1ccccc1 | 10.1016/S0960-894X(01)81250-6 | |||
44286696 | 174764 | 0 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 796 | 18 | 6 | 7 | 4.4 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N(C)CC(=O)N(C)C(Cc1ccccc1)C(N)=O | 10.1021/jm00037a005 | |||
CHEMBL431912 | 174764 | 0 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 796 | 18 | 6 | 7 | 4.4 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N(C)CC(=O)N(C)C(Cc1ccccc1)C(N)=O | 10.1021/jm00037a005 | |||
CHEMBL170026 | 215619 | 0 | None | - | 0 | Mouse | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N1C[C@H](Cc2ccccc2)NC(=O)[C@@H]1CC(=O)O | 10.1016/S0960-894X(01)80253-5 | |||||
10004579 | 85291 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 462 | 3 | 2 | 3 | 4.4 | CN1C(=O)[C@H](NC(=O)Nc2cccc(Br)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL2111923 | 85291 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 462 | 3 | 2 | 3 | 4.4 | CN1C(=O)[C@H](NC(=O)Nc2cccc(Br)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
15281997 | 55276 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 486 | 5 | 2 | 6 | 3.7 | Cc1cccc(NC(=O)NC2N=C(c3nccn3C)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1016/0960-894X(95)00557-A | |||
CHEMBL155627 | 55276 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 486 | 5 | 2 | 6 | 3.7 | Cc1cccc(NC(=O)NC2N=C(c3nccn3C)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1016/0960-894X(95)00557-A | |||
CHEMBL2369762 | 216459 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | None | None | None | CCCCC[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/0960-894X(94)85022-4 | |||||
44209152 | 65936 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 336 | 2 | 3 | 2 | 5.0 | O=C(Nc1ccc(Cl)cc1)Nc1cc2c3ccccc3nc-2c[nH]1 | 10.1016/S0960-894X(00)80682-4 | |||
CHEMBL169953 | 65936 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 336 | 2 | 3 | 2 | 5.0 | O=C(Nc1ccc(Cl)cc1)Nc1cc2c3ccccc3nc-2c[nH]1 | 10.1016/S0960-894X(00)80682-4 | |||
73349792 | 164193 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 669 | 13 | 5 | 7 | 5.3 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCSc1nc[nH]n1)c1ccccc1 | 10.1021/jm00092a007 | |||
CHEMBL407857 | 164193 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 669 | 13 | 5 | 7 | 5.3 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCSc1nc[nH]n1)c1ccccc1 | 10.1021/jm00092a007 | |||
44354100 | 123547 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 628 | 13 | 5 | 5 | 4.7 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@@H](CNC(=O)CCC(=O)O)Cc1ccccc1 | 10.1021/jm00105a062 | |||
CHEMBL337661 | 123547 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 628 | 13 | 5 | 5 | 4.7 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@@H](CNC(=O)CCC(=O)O)Cc1ccccc1 | 10.1021/jm00105a062 | |||
44354100 | 127589 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 628 | 13 | 5 | 5 | 4.7 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CNC(=O)CCC(=O)O)Cc1ccccc1 | 10.1016/S0960-894X(00)80685-X | |||
CHEMBL355656 | 127589 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 628 | 13 | 5 | 5 | 4.7 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CNC(=O)CCC(=O)O)Cc1ccccc1 | 10.1016/S0960-894X(00)80685-X | |||
101823779 | 8178 | 35 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b01558 | |||||
16162108 | 8178 | 35 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b01558 | |||||
8408 | 8178 | 35 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b01558 | |||||
CHEMBL4451154 | 8178 | 35 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b01558 | |||||
44408632 | 165016 | 0 | None | -3630 | 4 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 1212 | 31 | 12 | 15 | 3.8 | CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@H](Cc1cn(C(=O)OC23CC4CC(CC(C4)C2)C3)c2ccccc12)C(=O)O | 10.1021/jm050851n | |||
CHEMBL408832 | 165016 | 0 | None | -3630 | 4 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 1212 | 31 | 12 | 15 | 3.8 | CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@H](Cc1cn(C(=O)OC23CC4CC(CC(C4)C2)C3)c2ccccc12)C(=O)O | 10.1021/jm050851n | |||
44283055 | 106532 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 515 | 9 | 4 | 4 | 4.4 | O=C(NC(Cc1c[nH]c2ccccc12)C(=O)NC(CO)Cc1ccccc1)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1021/jm00086a017 | |||
CHEMBL285049 | 106532 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 515 | 9 | 4 | 4 | 4.4 | O=C(NC(Cc1c[nH]c2ccccc12)C(=O)NC(CO)Cc1ccccc1)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1021/jm00086a017 | |||
44591979 | 185839 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 426 | 7 | 4 | 3 | 3.2 | NC(=O)C(Cc1ccccc1)NC(=O)c1ccccc1NC(=O)c1cc2ccccc2[nH]1 | 10.1016/j.bmc.2009.02.012 | |||
CHEMBL471465 | 185839 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 426 | 7 | 4 | 3 | 3.2 | NC(=O)C(Cc1ccccc1)NC(=O)c1ccccc1NC(=O)c1cc2ccccc2[nH]1 | 10.1016/j.bmc.2009.02.012 | |||
54587151 | 68640 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 545 | 6 | 0 | 7 | 5.6 | COc1ccc(-c2cnc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)cc1OC | 10.1016/j.bmcl.2011.03.069 | |||
CHEMBL1773889 | 68640 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 545 | 6 | 0 | 7 | 5.6 | COc1ccc(-c2cnc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)cc1OC | 10.1016/j.bmcl.2011.03.069 | |||
5311201 | 214174 | 35 | None | -2570 | 6 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1016/0960-894X(95)00327-P | |||
CHEMBL9387 | 214174 | 35 | None | -2570 | 6 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1016/0960-894X(95)00327-P | |||
5311201 | 214174 | 35 | None | -2570 | 6 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00048a015 | |||
CHEMBL9387 | 214174 | 35 | None | -2570 | 6 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00048a015 | |||
5311201 | 214174 | 35 | None | -2570 | 6 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(01)80832-5 | |||
CHEMBL9387 | 214174 | 35 | None | -2570 | 6 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(01)80832-5 | |||
CHEMBL2111881 | 215999 | 0 | None | - | 0 | Guinea pig | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)[C@H](C)c1c[nH]c2ccccc12 | 10.1021/jm960078j | |||||
CHEMBL2111882 | 216000 | 0 | None | - | 0 | Guinea pig | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)[C@@H](C)c1c[nH]c2ccccc12 | 10.1021/jm960078j | |||||
44349278 | 23378 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 388 | 10 | 3 | 3 | 3.3 | CCCCCNC(=O)C(CCC(=O)O)NC(=O)c1ccc(Cl)c(Cl)c1 | 10.1021/jm00079a003 | |||
CHEMBL124090 | 23378 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 388 | 10 | 3 | 3 | 3.3 | CCCCCNC(=O)C(CCC(=O)O)NC(=O)c1ccc(Cl)c(Cl)c1 | 10.1021/jm00079a003 | |||
44283177 | 107080 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 655 | 16 | 2 | 5 | 7.6 | CCOC(=O)CCCCCC(=O)N(CCc1ccccc1)CC(C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1021/jm00086a017 | |||
CHEMBL289239 | 107080 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 655 | 16 | 2 | 5 | 7.6 | CCOC(=O)CCCCCC(=O)N(CCc1ccccc1)CC(C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1021/jm00086a017 | |||
44283085 | 106682 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 484 | 9 | 2 | 2 | 7.4 | CC(CCCCc1ccccc1)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1021/jm00086a017 | |||
CHEMBL286093 | 106682 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 484 | 9 | 2 | 2 | 7.4 | CC(CCCCc1ccccc1)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1021/jm00086a017 | |||
14208239 | 211277 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 398 | 4 | 3 | 3 | 4.2 | O=C1Nc2ccccc2C(c2ccccc2F)=NC1NCc1cc2ccccc2[nH]1 | 10.1021/jm00120a002 | |||
CHEMBL72550 | 211277 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 398 | 4 | 3 | 3 | 4.2 | O=C1Nc2ccccc2C(c2ccccc2F)=NC1NCc1cc2ccccc2[nH]1 | 10.1021/jm00120a002 | |||
10698051 | 213310 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 557 | 7 | 1 | 4 | 5.9 | CC(C)N(C(=O)CN1C(=O)C(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1021/jm960249k | |||
CHEMBL88545 | 213310 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 557 | 7 | 1 | 4 | 5.9 | CC(C)N(C(=O)CN1C(=O)C(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1021/jm960249k | |||
10698051 | 213310 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 557 | 7 | 1 | 4 | 5.9 | CC(C)N(C(=O)CN1C(=O)C(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1021/jm970265x | |||
CHEMBL88545 | 213310 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 557 | 7 | 1 | 4 | 5.9 | CC(C)N(C(=O)CN1C(=O)C(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1021/jm970265x | |||
70683305 | 80422 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 635 | 7 | 1 | 6 | 6.4 | Cc1cccc(CC2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1016/j.bmcl.2012.02.049 | |||
CHEMBL2017834 | 80422 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 635 | 7 | 1 | 6 | 6.4 | Cc1cccc(CC2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1016/j.bmcl.2012.02.049 | |||
14802543 | 177258 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 600 | 11 | 5 | 5 | 4.5 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NC[C@H](NC(=O)CC(=O)O)c1ccccc1 | 10.1021/jm00105a062 | |||
CHEMBL2112693 | 177258 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 600 | 11 | 5 | 5 | 4.5 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NC[C@H](NC(=O)CC(=O)O)c1ccccc1 | 10.1021/jm00105a062 | |||
CHEMBL444902 | 177258 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 600 | 11 | 5 | 5 | 4.5 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NC[C@H](NC(=O)CC(=O)O)c1ccccc1 | 10.1021/jm00105a062 | |||
44336539 | 11916 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 563 | 7 | 2 | 5 | 4.6 | COc1ccc(N(C)C(=O)CN2C(=O)C(NC(=O)Nc3ccccc3)C(=O)N(c3ccccc3)c3ccccc32)cc1 | 10.1016/j.bmcl.2015.03.051 | |||
CHEMBL105775 | 11916 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 563 | 7 | 2 | 5 | 4.6 | COc1ccc(N(C)C(=O)CN2C(=O)C(NC(=O)Nc3ccccc3)C(=O)N(c3ccccc3)c3ccccc32)cc1 | 10.1016/j.bmcl.2015.03.051 | |||
44349044 | 120084 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 580 | 9 | 4 | 5 | 3.9 | O=C(O)C[C@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@H]2C[C@H](NC(=O)OCc3ccccc3)C(=O)N12 | 10.1021/jm000959x | |||
CHEMBL331532 | 120084 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 580 | 9 | 4 | 5 | 3.9 | O=C(O)C[C@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@H]2C[C@H](NC(=O)OCc3ccccc3)C(=O)N12 | 10.1021/jm000959x | |||
44349044 | 120084 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 580 | 9 | 4 | 5 | 3.9 | O=C(O)C[C@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@H]2C[C@H](NC(=O)OCc3ccccc3)C(=O)N12 | 10.1016/s0960-894x(98)00677-5 | |||
CHEMBL331532 | 120084 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 580 | 9 | 4 | 5 | 3.9 | O=C(O)C[C@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@H]2C[C@H](NC(=O)OCc3ccccc3)C(=O)N12 | 10.1016/s0960-894x(98)00677-5 | |||
15104617 | 16775 | 0 | None | - | 0 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 498 | 13 | 2 | 3 | 6.3 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cc2ccccc2cn1 | 10.1021/jm00116a002 | |||
CHEMBL114916 | 16775 | 0 | None | - | 0 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 498 | 13 | 2 | 3 | 6.3 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cc2ccccc2cn1 | 10.1021/jm00116a002 | |||
14720390 | 56164 | 0 | None | - | 0 | Guinea pig | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 373 | 10 | 3 | 3 | 2.8 | CCCN(CCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1cc2ccccc2[nH]1 | 10.1021/jm00164a020 | |||
CHEMBL156415 | 56164 | 0 | None | - | 0 | Guinea pig | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 373 | 10 | 3 | 3 | 2.8 | CCCN(CCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1cc2ccccc2[nH]1 | 10.1021/jm00164a020 | |||
44349429 | 23609 | 0 | None | - | 0 | Rat | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 406 | 7 | 3 | 4 | 3.0 | O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)C1CC2CCCCC2CN1 | 10.1021/jm00079a003 | |||
CHEMBL124780 | 23609 | 0 | None | - | 0 | Rat | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 406 | 7 | 3 | 4 | 3.0 | O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)C1CC2CCCCC2CN1 | 10.1021/jm00079a003 | |||
23928173 | 120925 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 511 | 6 | 2 | 5 | 4.7 | CN(C)c1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1021/jm960669+ | |||
CHEMBL332931 | 120925 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 511 | 6 | 2 | 5 | 4.7 | CN(C)c1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1021/jm960669+ | |||
44381949 | 127502 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 474 | 3 | 3 | 4 | 4.6 | CN1C(=O)[C@H](NC(=O)Nc2cc3c4ccccc4nc-3c[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(00)80682-4 | |||
CHEMBL354802 | 127502 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 474 | 3 | 3 | 4 | 4.6 | CN1C(=O)[C@H](NC(=O)Nc2cc3c4ccccc4nc-3c[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(00)80682-4 | |||
14208209 | 170684 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 402 | 5 | 3 | 4 | 3.2 | O=C(CNc1ccccc1)NC1N=C(c2ccccc2F)c2ccccc2NC1=O | 10.1021/jm00047a021 | |||
CHEMBL420722 | 170684 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 402 | 5 | 3 | 4 | 3.2 | O=C(CNc1ccccc1)NC1N=C(c2ccccc2F)c2ccccc2NC1=O | 10.1021/jm00047a021 | |||
10841112 | 213875 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 588 | 8 | 0 | 6 | 6.1 | COc1ccc(N(C(=O)CN2C(=O)C(Cc3noc4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm970265x | |||
CHEMBL91986 | 213875 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 588 | 8 | 0 | 6 | 6.1 | COc1ccc(N(C(=O)CN2C(=O)C(Cc3noc4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm970265x | |||
10048206 | 205434 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 428 | 7 | 3 | 4 | 4.1 | O=C(Nc1ccccc1C(=O)NC(Cc1ccccc1)C(=O)O)c1cc2ccccc2o1 | 10.1016/j.bmc.2009.05.067 | |||
CHEMBL579245 | 205434 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 428 | 7 | 3 | 4 | 4.1 | O=C(Nc1ccccc1C(=O)NC(Cc1ccccc1)C(=O)O)c1cc2ccccc2o1 | 10.1016/j.bmc.2009.05.067 | |||
10674604 | 174707 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 571 | 6 | 1 | 4 | 6.3 | CC(C)(C)N(C(=O)CN1C(=O)C(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1021/jm970265x | |||
CHEMBL431451 | 174707 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 571 | 6 | 1 | 4 | 6.3 | CC(C)(C)N(C(=O)CN1C(=O)C(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1021/jm970265x | |||
16100408 | 148569 | 0 | None | -1202 | 3 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 1132 | 28 | 13 | 13 | 1.7 | CCCC[C@@H](NC(=O)[C@H](Cc1cc2ccccc2[nH]1)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(=O)O)C(=O)N[C@H](Cc1ccccc1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm061268p | |||
CHEMBL386186 | 148569 | 0 | None | -1202 | 3 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 1132 | 28 | 13 | 13 | 1.7 | CCCC[C@@H](NC(=O)[C@H](Cc1cc2ccccc2[nH]1)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(=O)O)C(=O)N[C@H](Cc1ccccc1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm061268p | |||
14208210 | 210982 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 413 | 3 | 2 | 4 | 4.1 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1cc2ccccc2o1 | 10.1021/jm00120a002 | |||
CHEMBL70856 | 210982 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 413 | 3 | 2 | 4 | 4.1 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1cc2ccccc2o1 | 10.1021/jm00120a002 | |||
14208268 | 211263 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 418 | 3 | 2 | 4 | 3.5 | CN1C(=O)C(NC(=O)c2ccc(Cl)cc2N)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL72428 | 211263 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 418 | 3 | 2 | 4 | 3.5 | CN1C(=O)C(NC(=O)c2ccc(Cl)cc2N)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
10073533 | 29326 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 472 | 7 | 3 | 5 | 3.5 | COc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CCC(=O)O)C2=O)c1 | 10.1021/jm00078a018 | |||
CHEMBL132603 | 29326 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 472 | 7 | 3 | 5 | 3.5 | COc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CCC(=O)O)C2=O)c1 | 10.1021/jm00078a018 | |||
155543846 | 179991 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 1838 | 72 | 19 | 24 | 2.4 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL4522865 | 179991 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 1838 | 72 | 19 | 24 | 2.4 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
10484212 | 106655 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 635 | 6 | 3 | 7 | 4.3 | Cc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(-c3nn[nH]n3)c1)N=C2c1ccccc1F | 10.1016/S0960-894X(96)00609-9 | |||
CHEMBL285921 | 106655 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 635 | 6 | 3 | 7 | 4.3 | Cc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(-c3nn[nH]n3)c1)N=C2c1ccccc1F | 10.1016/S0960-894X(96)00609-9 | |||
CHEMBL3142923 | 217916 | 0 | None | - | 0 | Guinea pig | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | None | None | None | COc1cccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c1 | 10.1021/jm960509y | |||||
53465844 | 76186 | 0 | None | - | 2 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 441 | 8 | 4 | 3 | 4.2 | O=C(Nc1ccccc1C(=O)N[C@H](CCc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 | 10.1021/jm200438b | |||
CHEMBL1933104 | 76186 | 0 | None | - | 2 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 441 | 8 | 4 | 3 | 4.2 | O=C(Nc1ccccc1C(=O)N[C@H](CCc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 | 10.1021/jm200438b | |||
CHEMBL208479 | 215978 | 0 | None | -3 | 4 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](CCCC)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm050921q | |||||
46235272 | 80420 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 589 | 8 | 1 | 7 | 4.9 | COCCC1CCCCN1C(=O)CN1C(=O)[C@@H](Cc2n[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc21 | 10.1016/j.bmcl.2012.02.049 | |||
CHEMBL2017832 | 80420 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 589 | 8 | 1 | 7 | 4.9 | COCCC1CCCCN1C(=O)CN1C(=O)[C@@H](Cc2n[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc21 | 10.1016/j.bmcl.2012.02.049 | |||
54586175 | 68692 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 504 | 5 | 0 | 6 | 5.8 | COc1ccc(-c2cnc(C(=O)N3CCN(c4ccc5ccoc5c4)CC3)nc2-c2ccc(C)cc2)cc1 | 10.1016/j.bmcl.2011.03.069 | |||
CHEMBL1774037 | 68692 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 504 | 5 | 0 | 6 | 5.8 | COc1ccc(-c2cnc(C(=O)N3CCN(c4ccc5ccoc5c4)CC3)nc2-c2ccc(C)cc2)cc1 | 10.1016/j.bmcl.2011.03.069 | |||
15667018 | 164561 | 0 | None | - | 0 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 998 | 27 | 10 | 11 | 2.5 | CCCC[C@H](NC(=O)c1ccc2cc(OS(=O)(=O)O)ccc2c1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00094a001 | |||
CHEMBL408286 | 164561 | 0 | None | - | 0 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 998 | 27 | 10 | 11 | 2.5 | CCCC[C@H](NC(=O)c1ccc2cc(OS(=O)(=O)O)ccc2c1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00094a001 | |||
14208212 | 109728 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 396 | 3 | 3 | 4 | 3.0 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)C1Cc2ccccc2N1 | 10.1021/jm00120a002 | |||
CHEMBL306369 | 109728 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 396 | 3 | 3 | 4 | 3.0 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)C1Cc2ccccc2N1 | 10.1021/jm00120a002 | |||
44311593 | 109797 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 402 | 3 | 2 | 3 | 3.8 | CN(C(=O)NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccccc1 | 10.1021/jm00120a002 | |||
CHEMBL306958 | 109797 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 402 | 3 | 2 | 3 | 3.8 | CN(C(=O)NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccccc1 | 10.1021/jm00120a002 | |||
11114607 | 122230 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 591 | 7 | 3 | 5 | 5.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=S)N(Cc3ccccc3)C(=S)C[C@H]12 | 10.1021/jm010898i | |||
CHEMBL3350852 | 122230 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 591 | 7 | 3 | 5 | 5.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=S)N(Cc3ccccc3)C(=S)C[C@H]12 | 10.1021/jm010898i | |||
19018662 | 33285 | 14 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 424 | 3 | 2 | 3 | 4.1 | CN1C(=O)C(NC(=O)Nc2ccc3c(c2)CCC3)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
CHEMBL136038 | 33285 | 14 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 424 | 3 | 2 | 3 | 4.1 | CN1C(=O)C(NC(=O)Nc2ccc3c(c2)CCC3)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
10436569 | 84620 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 515 | 5 | 2 | 4 | 4.3 | O=C(Nc1ccc(Cl)cc1)N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(=O)N2CCCC2)C1=O | 10.1021/jm00078a018 | |||
CHEMBL2092976 | 84620 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 515 | 5 | 2 | 4 | 4.3 | O=C(Nc1ccc(Cl)cc1)N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(=O)N2CCCC2)C1=O | 10.1021/jm00078a018 | |||
44280224 | 111561 | 0 | None | - | 1 | Mouse | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 757 | 16 | 4 | 7 | 5.8 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
CHEMBL31090 | 111561 | 0 | None | - | 1 | Mouse | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 757 | 16 | 4 | 7 | 5.8 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
44334337 | 11447 | 0 | None | - | 0 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 541 | 10 | 2 | 5 | 5.1 | Cc1cccc(NC(=O)N[C@H](CCC(=O)OCc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
CHEMBL103276 | 11447 | 0 | None | - | 0 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 541 | 10 | 2 | 5 | 5.1 | Cc1cccc(NC(=O)N[C@H](CCC(=O)OCc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
CHEMBL34853 | 218494 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | None | None | None | CCS[C@H]1CCN(C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(C)=O)[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00001a019 | |||||
14208300 | 84598 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 465 | 3 | 1 | 3 | 4.2 | CN1C(=O)[C@H](NC(=O)c2ccccc2Br)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
CHEMBL2092866 | 84598 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 465 | 3 | 1 | 3 | 4.2 | CN1C(=O)[C@H](NC(=O)c2ccccc2Br)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
10474221 | 23621 | 0 | None | - | 0 | Rat | 4.0 | pIC50 | = | 4.0 | Binding | ChEMBL | 368 | 8 | 3 | 3 | 2.9 | CC(C)(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 | 10.1021/jm00079a003 | |||
CHEMBL124822 | 23621 | 0 | None | - | 0 | Rat | 4.0 | pIC50 | = | 4.0 | Binding | ChEMBL | 368 | 8 | 3 | 3 | 2.9 | CC(C)(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 | 10.1021/jm00079a003 | |||
14991565 | 207121 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 839 | 23 | 8 | 8 | 3.6 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCCc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
CHEMBL59759 | 207121 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 839 | 23 | 8 | 8 | 3.6 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCCc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
CHEMBL408083 | 219477 | 0 | None | -2 | 4 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](CCCC)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm050921q | |||||
11812882 | 85369 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 483 | 5 | 3 | 5 | 2.5 | CN1C(=O)C[C@@H]2[C@@H](NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)OC(C)(C)C)CCCN2C1=O | 10.1021/jm010813d | |||
CHEMBL2112236 | 85369 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 483 | 5 | 3 | 5 | 2.5 | CN1C(=O)C[C@@H]2[C@@H](NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)OC(C)(C)C)CCCN2C1=O | 10.1021/jm010813d | |||
44591826 | 199311 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 425 | 8 | 3 | 5 | 3.4 | CSCCC(NC(=O)c1ccccc1NC(=O)c1cc2ccccc2n1C)C(=O)O | 10.1016/j.bmc.2009.02.012 | |||
CHEMBL520997 | 199311 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 425 | 8 | 3 | 5 | 3.4 | CSCCC(NC(=O)c1ccccc1NC(=O)c1cc2ccccc2n1C)C(=O)O | 10.1016/j.bmc.2009.02.012 | |||
44279862 | 105906 | 0 | None | - | 1 | Mouse | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 702 | 13 | 3 | 7 | 5.9 | Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
CHEMBL281017 | 105906 | 0 | None | - | 1 | Mouse | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 702 | 13 | 3 | 7 | 5.9 | Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
44286976 | 148723 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 768 | 18 | 8 | 7 | 3.7 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)NCC(=O)NC(Cc1ccccc1)C(N)=O | 10.1021/jm00037a005 | |||
CHEMBL38716 | 148723 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 768 | 18 | 8 | 7 | 3.7 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)NCC(=O)NC(Cc1ccccc1)C(N)=O | 10.1021/jm00037a005 | |||
15670985 | 213870 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 490 | 9 | 3 | 5 | 3.2 | COc1cccc(N(CC(=O)N(C)c2ccccc2)C(=O)CNC(=O)Nc2cccc(C(=O)O)c2)c1 | 10.1021/jm970373j | |||
CHEMBL9195 | 213870 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 490 | 9 | 3 | 5 | 3.2 | COc1cccc(N(CC(=O)N(C)c2ccccc2)C(=O)CNC(=O)Nc2cccc(C(=O)O)c2)c1 | 10.1021/jm970373j | |||
CHEMBL3142681 | 217905 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | None | None | None | Cc1ccccc1NC(=O)NCCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||||
70681224 | 80417 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 621 | 7 | 1 | 6 | 6.1 | O=C1C(Cc2c[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc2N1CC(=O)N1CCCCC1Cc1ccccn1 | 10.1016/j.bmcl.2012.02.049 | |||
CHEMBL2017829 | 80417 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 621 | 7 | 1 | 6 | 6.1 | O=C1C(Cc2c[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc2N1CC(=O)N1CCCCC1Cc1ccccn1 | 10.1016/j.bmcl.2012.02.049 | |||
52949124 | 7663 | 4 | None | -2 | 2 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
9055 | 7663 | 4 | None | -2 | 2 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
CHEMBL1269258 | 7663 | 4 | None | -2 | 2 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
DB12694 | 7663 | 4 | None | -2 | 2 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
CHEMBL328422 | 218075 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | None | None | None | Cc1cccc(C)c1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00173a006 | |||||
44381829 | 175307 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 840 | 23 | 10 | 10 | 2.9 | CC(C)(C)OC(=O)N[C@H](CNN[C@@H](CCCCNC(=O)/C=C/c1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)Cc1c[nH]c2ccccc12 | 10.1016/S0960-894X(00)80680-0 | |||
CHEMBL435465 | 175307 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 840 | 23 | 10 | 10 | 2.9 | CC(C)(C)OC(=O)N[C@H](CNN[C@@H](CCCCNC(=O)/C=C/c1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)Cc1c[nH]c2ccccc12 | 10.1016/S0960-894X(00)80680-0 | |||
10392523 | 214723 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 540 | 6 | 3 | 3 | 5.9 | Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)NC(C)(C)C)C2=O)c1 | 10.1016/S0960-894X(01)80832-5 | |||
CHEMBL96970 | 214723 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 540 | 6 | 3 | 3 | 5.9 | Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)NC(C)(C)C)C2=O)c1 | 10.1016/S0960-894X(01)80832-5 | |||
44370406 | 56661 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 529 | 16 | 2 | 4 | 6.6 | CCCCCN(CCCCC)C(=O)C(CCC(=O)OCc1ccccc1)NC(=O)Nc1ccc(Cl)cc1 | 10.1021/jm00164a020 | |||
CHEMBL156814 | 56661 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 529 | 16 | 2 | 4 | 6.6 | CCCCCN(CCCCC)C(=O)C(CCC(=O)OCc1ccccc1)NC(=O)Nc1ccc(Cl)cc1 | 10.1021/jm00164a020 | |||
70684970 | 84623 | 0 | None | - | 0 | Guinea pig | 4.0 | pIC50 | = | 4.0 | Binding | ChEMBL | 395 | 3 | 0 | 3 | 4.5 | CN1C[C@@H](CC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c2ccccc21 | 10.1021/jm00390a019 | |||
CHEMBL2092990 | 84623 | 0 | None | - | 0 | Guinea pig | 4.0 | pIC50 | = | 4.0 | Binding | ChEMBL | 395 | 3 | 0 | 3 | 4.5 | CN1C[C@@H](CC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c2ccccc21 | 10.1021/jm00390a019 | |||
44283515 | 106951 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 516 | 8 | 2 | 4 | 6.5 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)SCCc1ccccc1 | 10.1021/jm00086a017 | |||
CHEMBL288038 | 106951 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 516 | 8 | 2 | 4 | 6.5 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)SCCc1ccccc1 | 10.1021/jm00086a017 | |||
155540415 | 179718 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 1862 | 71 | 17 | 23 | 3.6 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
CHEMBL4516868 | 179718 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 1862 | 71 | 17 | 23 | 3.6 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
44349348 | 23707 | 0 | None | - | 0 | Rat | 4.0 | pIC50 | = | 4.0 | Binding | ChEMBL | 412 | 7 | 3 | 5 | 2.2 | N#Cc1cccc(C(=O)NC(CCC(=O)O)C(=O)NN2CCC3(CCCC3)CC2)c1 | 10.1021/jm00079a003 | |||
CHEMBL125316 | 23707 | 0 | None | - | 0 | Rat | 4.0 | pIC50 | = | 4.0 | Binding | ChEMBL | 412 | 7 | 3 | 5 | 2.2 | N#Cc1cccc(C(=O)NC(CCC(=O)O)C(=O)NN2CCC3(CCCC3)CC2)c1 | 10.1021/jm00079a003 | |||
45482490 | 204919 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 445 | 7 | 4 | 3 | 4.0 | O=C(Nc1ccccc1C(=O)NC(Cc1ccccc1)C(=O)O)c1cc2c(F)cccc2[nH]1 | 10.1016/j.bmc.2009.05.067 | |||
CHEMBL574715 | 204919 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 445 | 7 | 4 | 3 | 4.0 | O=C(Nc1ccccc1C(=O)NC(Cc1ccccc1)C(=O)O)c1cc2c(F)cccc2[nH]1 | 10.1016/j.bmc.2009.05.067 | |||
19766168 | 66331 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 367 | 4 | 3 | 3 | 2.5 | Cc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)O)C2=O)c1 | 10.1016/S0960-894X(00)80683-6 | |||
CHEMBL171722 | 66331 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 367 | 4 | 3 | 3 | 2.5 | Cc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)O)C2=O)c1 | 10.1016/S0960-894X(00)80683-6 | |||
71452691 | 85404 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 671 | 12 | 5 | 7 | 3.9 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)C[S+]([O-])c1nc[nH]n1)c1ccccc1 | 10.1021/jm00092a007 | |||
CHEMBL2112336 | 85404 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 671 | 12 | 5 | 7 | 3.9 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)C[S+]([O-])c1nc[nH]n1)c1ccccc1 | 10.1021/jm00092a007 | |||
CHEMBL172635 | 215633 | 0 | None | - | 0 | Mouse | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N1C[C@H](c2ccccc2)NC(=O)[C@@H]1CC(=O)O | 10.1016/S0960-894X(01)80253-5 | |||||
44280372 | 106163 | 0 | None | - | 1 | Mouse | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 787 | 17 | 4 | 8 | 5.8 | Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
CHEMBL282645 | 106163 | 0 | None | - | 1 | Mouse | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 787 | 17 | 4 | 8 | 5.8 | Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
136060577 | 94451 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 495 | 4 | 1 | 5 | 6.3 | O=C1c2ccccc2C(=O)N1Cc1c(O)ccc2c(/C=C/c3ccccc3)cc3nc4ccccc4n3c12 | 10.1016/j.bmcl.2007.02.071 | |||
CHEMBL233647 | 94451 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 495 | 4 | 1 | 5 | 6.3 | O=C1c2ccccc2C(=O)N1Cc1c(O)ccc2c(/C=C/c3ccccc3)cc3nc4ccccc4n3c12 | 10.1016/j.bmcl.2007.02.071 | |||
22883501 | 17193 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 552 | 6 | 2 | 6 | 5.0 | CC(C)(C)C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(N3CCCCC3)c2)N=C(c2ccccn2)c2ccccc21 | 10.1021/jm960669+ | |||
CHEMBL116300 | 17193 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 552 | 6 | 2 | 6 | 5.0 | CC(C)(C)C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(N3CCCCC3)c2)N=C(c2ccccn2)c2ccccc21 | 10.1021/jm960669+ | |||
54583297 | 68695 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 558 | 6 | 1 | 6 | 5.9 | COc1ccc(-c2cnc(C(=O)N3CCN(c4cc5ccccc5cc4C(=O)O)CC3)nc2-c2ccc(C)cc2)cc1 | 10.1016/j.bmcl.2011.03.069 | |||
CHEMBL1774040 | 68695 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 558 | 6 | 1 | 6 | 5.9 | COc1ccc(-c2cnc(C(=O)N3CCN(c4cc5ccccc5cc4C(=O)O)CC3)nc2-c2ccc(C)cc2)cc1 | 10.1016/j.bmcl.2011.03.069 | |||
14208254 | 211285 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 403 | 4 | 2 | 4 | 3.4 | COc1ccc(C(=O)NC2N=C(c3ccccc3F)c3ccccc3NC2=O)cc1 | 10.1021/jm00047a021 | |||
CHEMBL72599 | 211285 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 403 | 4 | 2 | 4 | 3.4 | COc1ccc(C(=O)NC2N=C(c3ccccc3F)c3ccccc3NC2=O)cc1 | 10.1021/jm00047a021 | |||
14802520 | 123071 | 1 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 628 | 13 | 5 | 5 | 4.7 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](CNC(=O)CCC(=O)O)Cc1ccccc1 | 10.1021/jm00105a062 | |||
CHEMBL335914 | 123071 | 1 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 628 | 13 | 5 | 5 | 4.7 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](CNC(=O)CCC(=O)O)Cc1ccccc1 | 10.1021/jm00105a062 | |||
14802520 | 127138 | 1 | None | - | 1 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 628 | 13 | 5 | 5 | 4.7 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CNC(=O)CCC(=O)O)Cc1ccccc1 | 10.1016/S0960-894X(00)80685-X | |||
CHEMBL353157 | 127138 | 1 | None | - | 1 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 628 | 13 | 5 | 5 | 4.7 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CNC(=O)CCC(=O)O)Cc1ccccc1 | 10.1016/S0960-894X(00)80685-X | |||
44368612 | 128774 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 612 | 13 | 5 | 4 | 4.4 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)C1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CNC(=O)CCC(=O)O)Cc1ccccc1 | 10.1021/jm00057a005 | |||
CHEMBL359361 | 128774 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 612 | 13 | 5 | 4 | 4.4 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)C1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CNC(=O)CCC(=O)O)Cc1ccccc1 | 10.1021/jm00057a005 | |||
23815458 | 174574 | 1 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 483 | 5 | 3 | 5 | 4.2 | CC(C)(C)C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(N)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm960669+ | |||
CHEMBL430516 | 174574 | 1 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 483 | 5 | 3 | 5 | 4.2 | CC(C)(C)C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(N)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm960669+ | |||
46235271 | 80423 | 2 | None | 2 | 2 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 649 | 7 | 1 | 6 | 6.7 | Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1021/acs.jmedchem.5b01110 | |||
CHEMBL2017835 | 80423 | 2 | None | 2 | 2 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 649 | 7 | 1 | 6 | 6.7 | Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1021/acs.jmedchem.5b01110 | |||
14208254 | 211285 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 403 | 4 | 2 | 4 | 3.4 | COc1ccc(C(=O)NC2N=C(c3ccccc3F)c3ccccc3NC2=O)cc1 | 10.1021/jm00120a002 | |||
CHEMBL72599 | 211285 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 403 | 4 | 2 | 4 | 3.4 | COc1ccc(C(=O)NC2N=C(c3ccccc3F)c3ccccc3NC2=O)cc1 | 10.1021/jm00120a002 | |||
44210427 | 127546 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 459 | 4 | 2 | 4 | 4.7 | CC(C)(C)OC(=O)CN1C(=O)C(NC(=O)Nc2cccc3ccccc23)CCc2ccccc21 | 10.1016/S0960-894X(00)80683-6 | |||
CHEMBL355319 | 127546 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 459 | 4 | 2 | 4 | 4.7 | CC(C)(C)OC(=O)CN1C(=O)C(NC(=O)Nc2cccc3ccccc23)CCc2ccccc21 | 10.1016/S0960-894X(00)80683-6 | |||
CHEMBL382051 | 219072 | 0 | None | -489 | 4 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm050921q | |||||
10555245 | 103265 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 580 | 9 | 4 | 5 | 3.9 | O=C(O)C[C@H](Cc1ccccc1)NC(=O)[C@H]1Cc2c([nH]c3ccccc23)[C@@H]2C[C@@H](NC(=O)OCc3ccccc3)C(=O)N21 | 10.1021/jm000959x | |||
CHEMBL262463 | 103265 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 580 | 9 | 4 | 5 | 3.9 | O=C(O)C[C@H](Cc1ccccc1)NC(=O)[C@H]1Cc2c([nH]c3ccccc23)[C@@H]2C[C@@H](NC(=O)OCc3ccccc3)C(=O)N21 | 10.1021/jm000959x | |||
44210426 | 65892 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 449 | 4 | 2 | 4 | 2.2 | Cc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)N3CCN(C)CC3)C2=O)c1 | 10.1016/S0960-894X(00)80683-6 | |||
CHEMBL169807 | 65892 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 449 | 4 | 2 | 4 | 2.2 | Cc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)N3CCN(C)CC3)C2=O)c1 | 10.1016/S0960-894X(00)80683-6 | |||
44300863 | 205128 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 619 | 7 | 4 | 6 | 3.7 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)NS(C)(=O)=O)c1)C[C@@H]2c1ccccc1 | 10.1016/0960-894X(95)00327-P | |||
CHEMBL57642 | 205128 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 619 | 7 | 4 | 6 | 3.7 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)NS(C)(=O)=O)c1)C[C@@H]2c1ccccc1 | 10.1016/0960-894X(95)00327-P | |||
73349793 | 213235 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 638 | 12 | 5 | 7 | 4.1 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCc1nnn[nH]1)c1ccccc1 | 10.1021/jm00092a007 | |||
CHEMBL88090 | 213235 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 638 | 12 | 5 | 7 | 4.1 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCc1nnn[nH]1)c1ccccc1 | 10.1021/jm00092a007 | |||
44329442 | 214451 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 540 | 6 | 3 | 3 | 5.9 | Cc1ccc([C@H]2C[C@@H](c3ccccc3)C[C@@H](NC(=O)Nc3cccc(C)c3)C(=O)N2CC(=O)NC(C)(C)C)cc1 | 10.1016/S0960-894X(01)80832-5 | |||
CHEMBL95369 | 214451 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 540 | 6 | 3 | 3 | 5.9 | Cc1ccc([C@H]2C[C@@H](c3ccccc3)C[C@@H](NC(=O)Nc3cccc(C)c3)C(=O)N2CC(=O)NC(C)(C)C)cc1 | 10.1016/S0960-894X(01)80832-5 | |||
44334237 | 114809 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 556 | 10 | 3 | 5 | 4.4 | Cc1cccc(NC(=O)N[C@H](CCC(=O)OCc2ccccc2)C(=O)N2CCC(NC(=O)c3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
CHEMBL319466 | 114809 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 556 | 10 | 3 | 5 | 4.4 | Cc1cccc(NC(=O)N[C@H](CCC(=O)OCc2ccccc2)C(=O)N2CCC(NC(=O)c3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
44370473 | 57636 | 0 | None | - | 0 | Guinea pig | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 435 | 15 | 3 | 4 | 4.3 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)Nc1cccc(OC)c1 | 10.1021/jm00164a020 | |||
CHEMBL157722 | 57636 | 0 | None | - | 0 | Guinea pig | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 435 | 15 | 3 | 4 | 4.3 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)Nc1cccc(OC)c1 | 10.1021/jm00164a020 | |||
10673193 | 104920 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 506 | 6 | 2 | 5 | 5.3 | CC(C)Oc1cccc(-n2c(CNC(=O)Nc3ccc(Br)cc3)nc3ccccc3c2=O)c1 | 10.1021/jm970373j | |||
CHEMBL273693 | 104920 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 506 | 6 | 2 | 5 | 5.3 | CC(C)Oc1cccc(-n2c(CNC(=O)Nc3ccc(Br)cc3)nc3ccccc3c2=O)c1 | 10.1021/jm970373j | |||
10006792 | 51699 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 517 | 6 | 2 | 5 | 4.9 | Cc1cccc(NC(=O)NC2N=C(c3ccccn3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1 | 10.1016/0960-894X(95)00557-A | |||
CHEMBL152306 | 51699 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 517 | 6 | 2 | 5 | 4.9 | Cc1cccc(NC(=O)NC2N=C(c3ccccn3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1 | 10.1016/0960-894X(95)00557-A | |||
44387108 | 175033 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 650 | 9 | 3 | 5 | 4.7 | COC(=O)[C@@]1(Cc2ccccc2)C[C@H]2[C@H](NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)C34CC5CC(CC(C5)C3)C4)CCCN2C1=O | 10.1016/0960-894X(96)00160-6 | |||
CHEMBL433770 | 175033 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 650 | 9 | 3 | 5 | 4.7 | COC(=O)[C@@]1(Cc2ccccc2)C[C@H]2[C@H](NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)C34CC5CC(CC(C5)C3)C4)CCCN2C1=O | 10.1016/0960-894X(96)00160-6 | |||
136055865 | 126974 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 468 | 4 | 3 | 7 | 3.4 | CN1C(=O)[C@@H](NC(=O)Nc2ccc(-c3noc(O)n3)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00032a003 | |||
CHEMBL351891 | 126974 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 468 | 4 | 3 | 7 | 3.4 | CN1C(=O)[C@@H](NC(=O)Nc2ccc(-c3noc(O)n3)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00032a003 | |||
10673193 | 104920 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 506 | 6 | 2 | 5 | 5.3 | CC(C)Oc1cccc(-n2c(CNC(=O)Nc3ccc(Br)cc3)nc3ccccc3c2=O)c1 | 10.1016/S0960-894X(97)00108-X | |||
CHEMBL273693 | 104920 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 506 | 6 | 2 | 5 | 5.3 | CC(C)Oc1cccc(-n2c(CNC(=O)Nc3ccc(Br)cc3)nc3ccccc3c2=O)c1 | 10.1016/S0960-894X(97)00108-X | |||
44572200 | 186122 | 0 | None | -14 | 2 | Human | 8.9 | pKd | = | 8.9 | Binding | ChEMBL | 510 | 3 | 2 | 3 | 4.3 | CN1C(=O)[C@@H](NC(=O)Nc2cccc(I)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm801439x | |||
CHEMBL473612 | 186122 | 0 | None | -14 | 2 | Human | 8.9 | pKd | = | 8.9 | Binding | ChEMBL | 510 | 3 | 2 | 3 | 4.3 | CN1C(=O)[C@@H](NC(=O)Nc2cccc(I)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm801439x | |||
CHEMBL475226 | 186122 | 0 | None | -14 | 2 | Human | 8.9 | pKd | = | 8.9 | Binding | ChEMBL | 510 | 3 | 2 | 3 | 4.3 | CN1C(=O)[C@@H](NC(=O)Nc2cccc(I)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm801439x | |||
90663557 | 113474 | 0 | None | 6165 | 2 | Rat | 10.7 | pKi | = | 10.7 | Binding | ChEMBL | 1152 | 31 | 11 | 13 | 2.0 | CCCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)NC(=O)c1ccccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm990252e | |||
CHEMBL3143672 | 113474 | 0 | None | 6165 | 2 | Rat | 10.7 | pKi | = | 10.7 | Binding | ChEMBL | 1152 | 31 | 11 | 13 | 2.0 | CCCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)NC(=O)c1ccccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm990252e | |||
443375 | 214385 | 45 | None | -2 | 5 | Human | 10.6 | pKi | = | 10.6 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm051219x | |||
CHEMBL9506 | 214385 | 45 | None | -2 | 5 | Human | 10.6 | pKi | = | 10.6 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm051219x | |||
10819755 | 172221 | 0 | None | 52480 | 2 | Rat | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 976 | 28 | 9 | 11 | 1.6 | CCCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm970477u | |||
CHEMBL423907 | 172221 | 0 | None | 52480 | 2 | Rat | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 976 | 28 | 9 | 11 | 1.6 | CCCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm970477u | |||
9919500 | 211704 | 3 | None | 7413 | 2 | Rat | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 976 | 28 | 9 | 11 | 1.6 | CCCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm970477u | |||
CHEMBL1161142 | 211704 | 3 | None | 7413 | 2 | Rat | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 976 | 28 | 9 | 11 | 1.6 | CCCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm970477u | |||
CHEMBL76248 | 211704 | 3 | None | 7413 | 2 | Rat | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 976 | 28 | 9 | 11 | 1.6 | CCCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm970477u | |||
9919500 | 211704 | 3 | None | 7413 | 2 | Rat | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 976 | 28 | 9 | 11 | 1.6 | CCCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm990252e | |||
CHEMBL1161142 | 211704 | 3 | None | 7413 | 2 | Rat | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 976 | 28 | 9 | 11 | 1.6 | CCCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm990252e | |||
CHEMBL76248 | 211704 | 3 | None | 7413 | 2 | Rat | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 976 | 28 | 9 | 11 | 1.6 | CCCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm990252e | |||
90662930 | 113348 | 0 | None | 3981 | 2 | Rat | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 1073 | 29 | 11 | 11 | 2.6 | CCCC[C@H](NC(=O)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)NC(=O)c1ccccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm990252e | |||
CHEMBL3142366 | 113348 | 0 | None | 3981 | 2 | Rat | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 1073 | 29 | 11 | 11 | 2.6 | CCCC[C@H](NC(=O)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)NC(=O)c1ccccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm990252e | |||
44357046 | 34832 | 2 | None | 18 | 2 | Rat | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 1012 | 28 | 9 | 13 | 0.7 | CSCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm970477u | |||
CHEMBL137280 | 34832 | 2 | None | 18 | 2 | Rat | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 1012 | 28 | 9 | 13 | 0.7 | CSCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm970477u | |||
4627 | 7609 | 50 | None | -1 | 5 | Rat | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm970477u | |||||
864 | 7609 | 50 | None | -1 | 5 | Rat | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm970477u | |||||
9833444 | 7609 | 50 | None | -1 | 5 | Rat | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm970477u | |||||
CHEMBL1121 | 7609 | 50 | None | -1 | 5 | Rat | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm970477u | |||||
DB09142 | 7609 | 50 | None | -1 | 5 | Rat | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm970477u | |||||
4627 | 7609 | 50 | None | -1 | 5 | Rat | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm990252e | |||||
864 | 7609 | 50 | None | -1 | 5 | Rat | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm990252e | |||||
9833444 | 7609 | 50 | None | -1 | 5 | Rat | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm990252e | |||||
CHEMBL1121 | 7609 | 50 | None | -1 | 5 | Rat | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm990252e | |||||
DB09142 | 7609 | 50 | None | -1 | 5 | Rat | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm990252e | |||||
108187 | 7713 | 37 | None | 4 | 5 | Rat | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1021/jm990967h | |||
873 | 7713 | 37 | None | 4 | 5 | Rat | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1021/jm990967h | |||
CHEMBL2062154 | 7713 | 37 | None | 4 | 5 | Rat | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1021/jm990967h | |||
CHEMBL287735 | 7713 | 37 | None | 4 | 5 | Rat | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1021/jm990967h | |||
5311201 | 214174 | 35 | None | 26 | 6 | Rat | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm990967h | |||
CHEMBL9387 | 214174 | 35 | None | 26 | 6 | Rat | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm990967h | |||
443375 | 214385 | 45 | None | -3 | 5 | Rat | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm990967h | |||
CHEMBL9506 | 214385 | 45 | None | -3 | 5 | Rat | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm990967h | |||
11804040 | 126226 | 0 | None | 2137 | 2 | Rat | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 976 | 28 | 9 | 11 | 1.6 | CCCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm970477u | |||
CHEMBL345049 | 126226 | 0 | None | 2137 | 2 | Rat | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 976 | 28 | 9 | 11 | 1.6 | CCCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm970477u | |||
CHEMBL384035 | 219095 | 4 | None | -8 | 4 | Guinea pig | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00122a026 | |||||
CHEMBL428666 | 219095 | 4 | None | -8 | 4 | Guinea pig | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00122a026 | |||||
10581797 | 70018 | 0 | None | 9120 | 2 | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 976 | 26 | 9 | 11 | 1.3 | CC[C@H](C)[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)[C@@H](C)CC | 10.1021/jm970477u | |||
CHEMBL1791002 | 70018 | 0 | None | 9120 | 2 | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 976 | 26 | 9 | 11 | 1.3 | CC[C@H](C)[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)[C@@H](C)CC | 10.1021/jm970477u | |||
4627 | 7609 | 50 | None | -2 | 5 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | None | None | None | None | 10.1021/jm8007618 | |||||
864 | 7609 | 50 | None | -2 | 5 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | None | None | None | None | 10.1021/jm8007618 | |||||
9833444 | 7609 | 50 | None | -2 | 5 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | None | None | None | None | 10.1021/jm8007618 | |||||
CHEMBL1121 | 7609 | 50 | None | -2 | 5 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | None | None | None | None | 10.1021/jm8007618 | |||||
DB09142 | 7609 | 50 | None | -2 | 5 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | None | None | None | None | 10.1021/jm8007618 | |||||
4627 | 7609 | 50 | None | -1 | 5 | Guinea pig | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9603072 | |||||
864 | 7609 | 50 | None | -1 | 5 | Guinea pig | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9603072 | |||||
9833444 | 7609 | 50 | None | -1 | 5 | Guinea pig | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9603072 | |||||
CHEMBL1121 | 7609 | 50 | None | -1 | 5 | Guinea pig | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9603072 | |||||
DB09142 | 7609 | 50 | None | -1 | 5 | Guinea pig | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9603072 | |||||
4627 | 7609 | 50 | None | -1 | 5 | Guinea pig | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00122a026 | |||||
864 | 7609 | 50 | None | -1 | 5 | Guinea pig | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00122a026 | |||||
9833444 | 7609 | 50 | None | -1 | 5 | Guinea pig | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00122a026 | |||||
CHEMBL1121 | 7609 | 50 | None | -1 | 5 | Guinea pig | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00122a026 | |||||
DB09142 | 7609 | 50 | None | -1 | 5 | Guinea pig | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00122a026 | |||||
121964 | 6995 | 34 | None | 831 | 2 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm990252e | |||||
858 | 6995 | 34 | None | 831 | 2 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm990252e | |||||
CHEMBL323521 | 6995 | 34 | None | 831 | 2 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm990252e | |||||
14208194 | 170215 | 2 | None | 1122 | 2 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm9703247 | |||
CHEMBL419764 | 170215 | 2 | None | 1122 | 2 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm9703247 | |||
CHEMBL384035 | 219095 | 4 | None | -8 | 4 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/j.bmcl.2003.11.001 | |||||
CHEMBL428666 | 219095 | 4 | None | -8 | 4 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/j.bmcl.2003.11.001 | |||||
53465844 | 76186 | 0 | None | 131 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 441 | 8 | 4 | 3 | 4.2 | O=C(Nc1ccccc1C(=O)N[C@H](CCc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 | 10.1021/jm200438b | |||
CHEMBL1933104 | 76186 | 0 | None | 131 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 441 | 8 | 4 | 3 | 4.2 | O=C(Nc1ccccc1C(=O)N[C@H](CCc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 | 10.1021/jm200438b | |||
4627 | 7609 | 50 | None | -1 | 5 | Rat | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9703247 | |||||
864 | 7609 | 50 | None | -1 | 5 | Rat | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9703247 | |||||
9833444 | 7609 | 50 | None | -1 | 5 | Rat | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9703247 | |||||
CHEMBL1121 | 7609 | 50 | None | -1 | 5 | Rat | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9703247 | |||||
DB09142 | 7609 | 50 | None | -1 | 5 | Rat | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9703247 | |||||
10701167 | 70019 | 0 | None | - | 1 | Rat | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 990 | 27 | 8 | 11 | 1.8 | CCCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N(C)[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O)[C@@H](C)CC | 10.1021/jm970477u | |||
CHEMBL1791005 | 70019 | 0 | None | - | 1 | Rat | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 990 | 27 | 8 | 11 | 1.8 | CCCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N(C)[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O)[C@@H](C)CC | 10.1021/jm970477u | |||
CHEMBL2115177 | 216039 | 0 | None | - | 1 | Rat | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | None | None | None | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm990252e | |||||
4627 | 7609 | 50 | None | -1 | 5 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2003.11.001 | |||||
864 | 7609 | 50 | None | -1 | 5 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2003.11.001 | |||||
9833444 | 7609 | 50 | None | -1 | 5 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2003.11.001 | |||||
CHEMBL1121 | 7609 | 50 | None | -1 | 5 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2003.11.001 | |||||
DB09142 | 7609 | 50 | None | -1 | 5 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2003.11.001 | |||||
10507071 | 120387 | 0 | None | - | 1 | Rat | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 559 | 7 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm9703247 | |||
CHEMBL332261 | 120387 | 0 | None | - | 1 | Rat | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 559 | 7 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm9703247 | |||
4627 | 7609 | 50 | None | -1 | 5 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00126a007 | |||||
864 | 7609 | 50 | None | -1 | 5 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00126a007 | |||||
9833444 | 7609 | 50 | None | -1 | 5 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00126a007 | |||||
CHEMBL1121 | 7609 | 50 | None | -1 | 5 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00126a007 | |||||
DB09142 | 7609 | 50 | None | -1 | 5 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00126a007 | |||||
4627 | 7609 | 50 | None | -1 | 5 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(00)80678-2 | |||||
864 | 7609 | 50 | None | -1 | 5 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(00)80678-2 | |||||
9833444 | 7609 | 50 | None | -1 | 5 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(00)80678-2 | |||||
CHEMBL1121 | 7609 | 50 | None | -1 | 5 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(00)80678-2 | |||||
DB09142 | 7609 | 50 | None | -1 | 5 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(00)80678-2 | |||||
4627 | 7609 | 50 | None | -1 | 5 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00122a026 | |||||
864 | 7609 | 50 | None | -1 | 5 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00122a026 | |||||
9833444 | 7609 | 50 | None | -1 | 5 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00122a026 | |||||
CHEMBL1121 | 7609 | 50 | None | -1 | 5 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00122a026 | |||||
DB09142 | 7609 | 50 | None | -1 | 5 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00122a026 | |||||
4627 | 7609 | 50 | None | -1 | 5 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm0000416 | |||||
864 | 7609 | 50 | None | -1 | 5 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm0000416 | |||||
9833444 | 7609 | 50 | None | -1 | 5 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm0000416 | |||||
CHEMBL1121 | 7609 | 50 | None | -1 | 5 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm0000416 | |||||
DB09142 | 7609 | 50 | None | -1 | 5 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm0000416 | |||||
4627 | 7609 | 50 | None | -1 | 5 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00053a022 | |||||
864 | 7609 | 50 | None | -1 | 5 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00053a022 | |||||
9833444 | 7609 | 50 | None | -1 | 5 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00053a022 | |||||
CHEMBL1121 | 7609 | 50 | None | -1 | 5 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00053a022 | |||||
DB09142 | 7609 | 50 | None | -1 | 5 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00053a022 | |||||
443375 | 214385 | 45 | None | -3 | 5 | Rat | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00084a009 | |||
CHEMBL9506 | 214385 | 45 | None | -3 | 5 | Rat | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00084a009 | |||
5311400 | 10066 | 1 | None | -2 | 3 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2003.11.001 | |||||
900 | 10066 | 1 | None | -2 | 3 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2003.11.001 | |||||
CHEMBL262197 | 10066 | 1 | None | -2 | 3 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2003.11.001 | |||||
CHEMBL384035 | 219095 | 4 | None | -8 | 4 | Guinea pig | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00126a007 | |||||
CHEMBL428666 | 219095 | 4 | None | -8 | 4 | Guinea pig | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00126a007 | |||||
CHEMBL384035 | 219095 | 4 | None | -8 | 4 | Guinea pig | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00122a026 | |||||
CHEMBL428666 | 219095 | 4 | None | -8 | 4 | Guinea pig | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00122a026 | |||||
44357045 | 33348 | 0 | None | 85 | 2 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 1012 | 28 | 9 | 13 | 0.7 | CSCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm970477u | |||
CHEMBL136096 | 33348 | 0 | None | 85 | 2 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 1012 | 28 | 9 | 13 | 0.7 | CSCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm970477u | |||
CHEMBL2369815 | 216472 | 0 | None | 85 | 2 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | None | None | None | CSCC[C@@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCSC)C(=O)N[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm990252e | |||||
10557073 | 23144 | 0 | None | 3467 | 2 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 763 | 20 | 7 | 8 | 2.3 | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C | 10.1021/jm0000416 | |||
CHEMBL122934 | 23144 | 0 | None | 3467 | 2 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 763 | 20 | 7 | 8 | 2.3 | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C | 10.1021/jm0000416 | |||
10004216 | 11515 | 0 | None | -11 | 2 | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 456 | 6 | 2 | 3 | 4.9 | CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21 | 10.1016/0960-894X(95)00528-2 | |||
CHEMBL103750 | 11515 | 0 | None | -11 | 2 | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 456 | 6 | 2 | 3 | 4.9 | CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21 | 10.1016/0960-894X(95)00528-2 | |||
CHEMBL1172429 | 215366 | 0 | None | 26 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/j.bmcl.2010.05.078 | |||||
44359425 | 21516 | 0 | None | - | 1 | Guinea pig | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 1031 | 30 | 11 | 11 | 1.0 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00122a026 | |||
CHEMBL1206331 | 21516 | 0 | None | - | 1 | Guinea pig | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 1031 | 30 | 11 | 11 | 1.0 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00122a026 | |||
CHEMBL262687 | 21516 | 0 | None | - | 1 | Guinea pig | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 1031 | 30 | 11 | 11 | 1.0 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00122a026 | |||
443375 | 214385 | 45 | None | -2 | 5 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1016/j.bmcl.2007.09.093 | |||
CHEMBL9506 | 214385 | 45 | None | -2 | 5 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1016/j.bmcl.2007.09.093 | |||
44328894 | 115401 | 0 | None | -25 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 587 | 5 | 2 | 4 | 4.8 | O=C(Nc1ccc(F)cc1)NC1C(=O)N(CC(=O)N2CC3CCC(CC3)C2)c2ccccc2N(c2ccccc2F)C1=O | 10.1016/S0960-894X(96)00613-0 | |||
CHEMBL320624 | 115401 | 0 | None | -25 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 587 | 5 | 2 | 4 | 4.8 | O=C(Nc1ccc(F)cc1)NC1C(=O)N(CC(=O)N2CC3CCC(CC3)C2)c2ccccc2N(c2ccccc2F)C1=O | 10.1016/S0960-894X(96)00613-0 | |||
3476 | 8182 | 9 | None | 2 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 | 10.1021/jm200438b | |||
59751 | 8182 | 9 | None | 2 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 | 10.1021/jm200438b | |||
878 | 8182 | 9 | None | 2 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 | 10.1021/jm200438b | |||
CHEMBL39263 | 8182 | 9 | None | 2 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 | 10.1021/jm200438b | |||
10840582 | 174758 | 0 | None | 257 | 2 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 559 | 7 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@H]12 | 10.1021/jm9703247 | |||
CHEMBL431858 | 174758 | 0 | None | 257 | 2 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 559 | 7 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@H]12 | 10.1021/jm9703247 | |||
45486933 | 203715 | 1 | None | 3 | 2 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 520 | 7 | 2 | 6 | 5.3 | CC(CNC(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2009.09.064 | |||
CHEMBL566360 | 203715 | 1 | None | 3 | 2 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 520 | 7 | 2 | 6 | 5.3 | CC(CNC(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2009.09.064 | |||
45487006 | 205691 | 0 | None | -10 | 2 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 666 | 8 | 3 | 6 | 5.0 | O=C(N[C@@H](Cc1ccc(Cl)c(Br)c1)C(=O)O)c1ccc(Br)cc1NS(=O)(=O)c1cccc2nccnc12 | 10.1016/j.bmcl.2009.09.065 | |||
CHEMBL584525 | 205691 | 0 | None | -10 | 2 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 666 | 8 | 3 | 6 | 5.0 | O=C(N[C@@H](Cc1ccc(Cl)c(Br)c1)C(=O)O)c1ccc(Br)cc1NS(=O)(=O)c1cccc2nccnc12 | 10.1016/j.bmcl.2009.09.065 | |||
10767708 | 21318 | 0 | None | -138 | 2 | Rat | 7.0 | pKi | = | 7 | Binding | ChEMBL | 500 | 6 | 2 | 3 | 5.6 | O=C(Nc1ccccc1)NC1C(=O)N(CCC2CCCC2)c2ccccc2N(c2ccccc2F)C1=O | 10.1021/jm990967h | |||
CHEMBL120296 | 21318 | 0 | None | -138 | 2 | Rat | 7.0 | pKi | = | 7 | Binding | ChEMBL | 500 | 6 | 2 | 3 | 5.6 | O=C(Nc1ccccc1)NC1C(=O)N(CCC2CCCC2)c2ccccc2N(c2ccccc2F)C1=O | 10.1021/jm990967h | |||
45486994 | 204503 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 506 | 7 | 2 | 6 | 4.8 | O=C(NCCc1ccc(Cl)cc1)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 | 10.1016/j.bmcl.2009.09.064 | |||
CHEMBL571457 | 204503 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 506 | 7 | 2 | 6 | 4.8 | O=C(NCCc1ccc(Cl)cc1)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 | 10.1016/j.bmcl.2009.09.064 | |||
44408411 | 168089 | 0 | None | -2089 | 4 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 1242 | 31 | 11 | 15 | 4.4 | CCCC[C@@H](C(=O)N[C@@H](Cc1cn(C(C)=O)c2ccccc12)C(=O)O)N(C(=O)Nc1ccccc1Cl)C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)N(C)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O | 10.1021/jm050851n | |||
CHEMBL412331 | 168089 | 0 | None | -2089 | 4 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 1242 | 31 | 11 | 15 | 4.4 | CCCC[C@@H](C(=O)N[C@@H](Cc1cn(C(C)=O)c2ccccc12)C(=O)O)N(C(=O)Nc1ccccc1Cl)C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)N(C)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O | 10.1021/jm050851n | |||
118719285 | 122261 | 0 | None | -25 | 3 | Guinea pig | 6.0 | pKi | = | 6 | Binding | ChEMBL | 733 | 15 | 5 | 7 | 4.7 | CN(C)[C@@H](Cc1cccc2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C)c1ccccc1 | 10.1021/jm00053a022 | |||
CHEMBL3351057 | 122261 | 0 | None | -25 | 3 | Guinea pig | 6.0 | pKi | = | 6 | Binding | ChEMBL | 733 | 15 | 5 | 7 | 4.7 | CN(C)[C@@H](Cc1cccc2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C)c1ccccc1 | 10.1021/jm00053a022 | |||
44265924 | 214160 | 0 | None | - | 1 | Rat | 6.0 | pKi | = | 6 | Binding | ChEMBL | 363 | 5 | 1 | 1 | 5.7 | O=C(NCC=C(c1ccccc1)c1ccccc1)c1cccc2ccccc12 | 10.1021/jm00084a009 | |||
CHEMBL9379 | 214160 | 0 | None | - | 1 | Rat | 6.0 | pKi | = | 6 | Binding | ChEMBL | 363 | 5 | 1 | 1 | 5.7 | O=C(NCC=C(c1ccccc1)c1ccccc1)c1cccc2ccccc12 | 10.1021/jm00084a009 | |||
10440219 | 175477 | 0 | None | -25 | 2 | Guinea pig | 6.0 | pKi | = | 6 | Binding | ChEMBL | 776 | 15 | 6 | 7 | 4.4 | CN(C)C(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)c1ccccc1 | 10.1016/S0960-894X(00)80678-2 | |||
CHEMBL436722 | 175477 | 0 | None | -25 | 2 | Guinea pig | 6.0 | pKi | = | 6 | Binding | ChEMBL | 776 | 15 | 6 | 7 | 4.4 | CN(C)C(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)c1ccccc1 | 10.1016/S0960-894X(00)80678-2 | |||
11527738 | 82764 | 0 | None | -10964 | 4 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 518 | 7 | 2 | 5 | 5.2 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1016/j.bmc.2007.12.047 | |||
CHEMBL205455 | 82764 | 0 | None | -10964 | 4 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 518 | 7 | 2 | 5 | 5.2 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1016/j.bmc.2007.12.047 | |||
CHEMBL411201 | 219651 | 0 | None | -4786 | 4 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm0303103 | |||||
44408484 | 144286 | 0 | None | -19498 | 4 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 1033 | 30 | 13 | 12 | 1.4 | CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm050851n | |||
CHEMBL375412 | 144286 | 0 | None | -19498 | 4 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 1033 | 30 | 13 | 12 | 1.4 | CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm050851n | |||
44418924 | 163661 | 0 | None | -19952 | 4 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 1031 | 27 | 13 | 12 | 0.2 | CCCC[C@H](NC(=O)[C@H](N)Cc1cc2ccccc2[nH]1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm061268p | |||
CHEMBL407198 | 163661 | 0 | None | -19952 | 4 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 1031 | 27 | 13 | 12 | 0.2 | CCCC[C@H](NC(=O)[C@H](N)Cc1cc2ccccc2[nH]1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm061268p | |||
9844256 | 18569 | 0 | None | -3 | 2 | Guinea pig | 5.0 | pKi | = | 5 | Binding | ChEMBL | 406 | 7 | 3 | 2 | 4.6 | O=C(O)CCNC(=O)c1cc(-c2ccccc2)[nH]c1CC12CC3CC(CC(C3)C1)C2 | 10.1021/jm049069y | |||
CHEMBL1181869 | 18569 | 0 | None | -3 | 2 | Guinea pig | 5.0 | pKi | = | 5 | Binding | ChEMBL | 406 | 7 | 3 | 2 | 4.6 | O=C(O)CCNC(=O)c1cc(-c2ccccc2)[nH]c1CC12CC3CC(CC(C3)C1)C2 | 10.1021/jm049069y | |||
CHEMBL2067947 | 18569 | 0 | None | -3 | 2 | Guinea pig | 5.0 | pKi | = | 5 | Binding | ChEMBL | 406 | 7 | 3 | 2 | 4.6 | O=C(O)CCNC(=O)c1cc(-c2ccccc2)[nH]c1CC12CC3CC(CC(C3)C1)C2 | 10.1021/jm049069y | |||
44403980 | 18577 | 0 | None | -398 | 2 | Guinea pig | 5.0 | pKi | = | 5 | Binding | ChEMBL | 677 | 11 | 5 | 6 | 5.2 | CN(C(=O)c1cc2[nH]cnc2cc1C(=O)NCC12CC3CC(CC(C3)C1)C2)[C@@H](Cc1ccccc1)C(=O)Nc1cc(C(=O)O)cc(C(=O)O)c1 | 10.1021/jm049069y | |||
CHEMBL1181938 | 18577 | 0 | None | -398 | 2 | Guinea pig | 5.0 | pKi | = | 5 | Binding | ChEMBL | 677 | 11 | 5 | 6 | 5.2 | CN(C(=O)c1cc2[nH]cnc2cc1C(=O)NCC12CC3CC(CC(C3)C1)C2)[C@@H](Cc1ccccc1)C(=O)Nc1cc(C(=O)O)cc(C(=O)O)c1 | 10.1021/jm049069y | |||
CHEMBL2067951 | 18577 | 0 | None | -398 | 2 | Guinea pig | 5.0 | pKi | = | 5 | Binding | ChEMBL | 677 | 11 | 5 | 6 | 5.2 | CN(C(=O)c1cc2[nH]cnc2cc1C(=O)NCC12CC3CC(CC(C3)C1)C2)[C@@H](Cc1ccccc1)C(=O)Nc1cc(C(=O)O)cc(C(=O)O)c1 | 10.1021/jm049069y | |||
10771043 | 32925 | 0 | None | -61 | 2 | Guinea pig | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 707 | 10 | 4 | 4 | 6.9 | O=C(O)c1cccc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)c1 | 10.1021/jm00021a019 | |||
CHEMBL135658 | 32925 | 0 | None | -61 | 2 | Guinea pig | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 707 | 10 | 4 | 4 | 6.9 | O=C(O)c1cccc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)c1 | 10.1021/jm00021a019 | |||
44212464 | 70912 | 0 | None | - | 1 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 527 | 8 | 2 | 5 | 3.6 | CC(C)CCN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)C(=O)N(CCN2CCOCC2)c2ccccc21 | 10.1016/j.bmc.2011.05.057 | |||
CHEMBL1808399 | 70912 | 0 | None | - | 1 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 527 | 8 | 2 | 5 | 3.6 | CC(C)CCN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)C(=O)N(CCN2CCOCC2)c2ccccc21 | 10.1016/j.bmc.2011.05.057 | |||
56673524 | 70929 | 0 | None | - | 1 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 589 | 7 | 2 | 5 | 4.2 | O=C(Nc1ccc(F)cc1)NC1C(=O)N(CCN2CCOCC2)c2ccccc2N(CC23CC4CC(CC(C4)C2)C3)C1=O | 10.1016/j.bmc.2011.05.057 | |||
CHEMBL1808418 | 70929 | 0 | None | - | 1 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 589 | 7 | 2 | 5 | 4.2 | O=C(Nc1ccc(F)cc1)NC1C(=O)N(CCN2CCOCC2)c2ccccc2N(CC23CC4CC(CC(C4)C2)C3)C1=O | 10.1016/j.bmc.2011.05.057 | |||
10438352 | 16571 | 0 | None | - | 1 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 588 | 8 | 3 | 6 | 3.9 | COC(=O)[C@@]1(Cc2ccccc2)C[C@@H]2[C@@H](NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)OC(C)(C)C)CCCN2C1=O | 10.1021/jm9703247 | |||
CHEMBL113699 | 16571 | 0 | None | - | 1 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 588 | 8 | 3 | 6 | 3.9 | COC(=O)[C@@]1(Cc2ccccc2)C[C@@H]2[C@@H](NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)OC(C)(C)C)CCCN2C1=O | 10.1021/jm9703247 | |||
10054705 | 115204 | 0 | None | -28 | 2 | Guinea pig | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 625 | 10 | 3 | 4 | 6.5 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccc(Cl)cc1Cl)CC(=O)O | 10.1021/jm00072a005 | |||
CHEMBL319880 | 115204 | 0 | None | -28 | 2 | Guinea pig | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 625 | 10 | 3 | 4 | 6.5 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccc(Cl)cc1Cl)CC(=O)O | 10.1021/jm00072a005 | |||
44357069 | 162472 | 0 | None | -147 | 2 | Guinea pig | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 675 | 9 | 5 | 5 | 5.4 | C[C@@H](NC(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC12CC3CC(CC(C3)C1)C2)C(=O)Nc1cc(C(=O)O)cc(C(=O)O)c1 | 10.1021/jm00021a019 | |||
CHEMBL405062 | 162472 | 0 | None | -147 | 2 | Guinea pig | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 675 | 9 | 5 | 5 | 5.4 | C[C@@H](NC(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC12CC3CC(CC(C3)C1)C2)C(=O)Nc1cc(C(=O)O)cc(C(=O)O)c1 | 10.1021/jm00021a019 | |||
10077166 | 106710 | 0 | None | -75 | 2 | Guinea pig | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 591 | 10 | 3 | 4 | 5.8 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N(CCc1ccc(Cl)cc1)CC(=O)O | 10.1016/s0960-894x(98)00231-5 | |||
CHEMBL286247 | 106710 | 0 | None | -75 | 2 | Guinea pig | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 591 | 10 | 3 | 4 | 5.8 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N(CCc1ccc(Cl)cc1)CC(=O)O | 10.1016/s0960-894x(98)00231-5 | |||
44280157 | 162508 | 0 | None | -75 | 2 | Guinea pig | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 667 | 8 | 3 | 5 | 6.9 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1CC[C@H](Oc2ccc(Cl)cc2Cl)C[C@H]1C(=O)O | 10.1016/s0960-894x(98)00231-5 | |||
CHEMBL405468 | 162508 | 0 | None | -75 | 2 | Guinea pig | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 667 | 8 | 3 | 5 | 6.9 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1CC[C@H](Oc2ccc(Cl)cc2Cl)C[C@H]1C(=O)O | 10.1016/s0960-894x(98)00231-5 | |||
10257865 | 215217 | 4 | None | -173 | 5 | Guinea pig | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 591 | 10 | 3 | 4 | 5.8 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccc(Cl)cc1)CC(=O)O | 10.1021/jm00072a005 | |||
CHEMBL99939 | 215217 | 4 | None | -173 | 5 | Guinea pig | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 591 | 10 | 3 | 4 | 5.8 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccc(Cl)cc1)CC(=O)O | 10.1021/jm00072a005 | |||
56683505 | 70915 | 0 | None | - | 1 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 571 | 8 | 2 | 5 | 3.7 | CC(C)CCN1C(=O)C(NC(=O)Nc2ccc(Br)cc2)C(=O)N(CCN2CCOCC2)c2ccccc21 | 10.1016/j.bmc.2011.05.057 | |||
CHEMBL1808402 | 70915 | 0 | None | - | 1 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 571 | 8 | 2 | 5 | 3.7 | CC(C)CCN1C(=O)C(NC(=O)Nc2ccc(Br)cc2)C(=O)N(CCN2CCOCC2)c2ccccc21 | 10.1016/j.bmc.2011.05.057 | |||
CHEMBL430298 | 220397 | 0 | None | -2137 | 4 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm0303103 | |||||
44331483 | 114275 | 0 | None | -25 | 2 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 541 | 5 | 1 | 4 | 6.1 | O=C(NC1C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc2N(C2CCCCC2)C1=O)Oc1ccccc1 | 10.1016/S0960-894X(96)00544-6 | |||
CHEMBL318569 | 114275 | 0 | None | -25 | 2 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 541 | 5 | 1 | 4 | 6.1 | O=C(NC1C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc2N(C2CCCCC2)C1=O)Oc1ccccc1 | 10.1016/S0960-894X(96)00544-6 | |||
10840039 | 120570 | 0 | None | -16 | 2 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 534 | 6 | 2 | 4 | 6.2 | CSc1cccc(NC(=O)NC2C(=O)N(CCC(C)(C)C)c3ccccc3N(c3ccccc3F)C2=O)c1 | 10.1021/jm990967h | |||
CHEMBL332403 | 120570 | 0 | None | -16 | 2 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 534 | 6 | 2 | 4 | 6.2 | CSc1cccc(NC(=O)NC2C(=O)N(CCC(C)(C)C)c3ccccc3N(c3ccccc3F)C2=O)c1 | 10.1021/jm990967h | |||
CHEMBL218327 | 216173 | 0 | None | -2630 | 4 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm050921q | |||||
CHEMBL1207511 | 215388 | 0 | None | -2398 | 2 | Guinea pig | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/S0960-894X(00)80678-2 | |||||
CHEMBL412917 | 215388 | 0 | None | -2398 | 2 | Guinea pig | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/S0960-894X(00)80678-2 | |||||
CHEMBL353862 | 218507 | 0 | None | -77 | 3 | Guinea pig | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | None | None | None | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)c1ccccc1 | 10.1016/S0960-894X(00)80678-2 | |||||
CHEMBL3350335 | 218253 | 0 | None | -245 | 2 | Guinea pig | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C | 10.1021/jm00053a022 | |||||
10626579 | 22283 | 0 | None | -38 | 2 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 554 | 6 | 2 | 4 | 6.2 | CC(C)(C)CCN1C(=O)C(NC(=O)Nc2cccc(OC(F)(F)F)c2)C(=O)N(c2ccccc2)c2ccccc21 | 10.1021/jm990967h | |||
CHEMBL121703 | 22283 | 0 | None | -38 | 2 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 554 | 6 | 2 | 4 | 6.2 | CC(C)(C)CCN1C(=O)C(NC(=O)Nc2cccc(OC(F)(F)F)c2)C(=O)N(c2ccccc2)c2ccccc21 | 10.1021/jm990967h | |||
10552321 | 170689 | 0 | None | -165 | 2 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 470 | 5 | 2 | 3 | 5.3 | CC(C)(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21 | 10.1021/jm990967h | |||
CHEMBL420728 | 170689 | 0 | None | -165 | 2 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 470 | 5 | 2 | 3 | 5.3 | CC(C)(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21 | 10.1021/jm990967h | |||
11698512 | 175034 | 0 | None | -21 | 3 | Guinea pig | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 435 | 8 | 3 | 3 | 5.5 | CCCc1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 | 10.1021/jm0490686 | |||
CHEMBL433776 | 175034 | 0 | None | -21 | 3 | Guinea pig | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 435 | 8 | 3 | 3 | 5.5 | CCCc1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 | 10.1021/jm0490686 | |||
3503 | 8674 | 16 | None | -1174 | 2 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 534 | 5 | 2 | 3 | 6.1 | O=C(N[C@H]1C(=O)N(c2ccccc2)c2c(N(C1=O)CC13CC4CC(C3)CC(C1)C4)cccc2)Nc1ccccc1 | 10.1016/S0960-894X(96)00544-6 | |||
5311147 | 8674 | 16 | None | -1174 | 2 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 534 | 5 | 2 | 3 | 6.1 | O=C(N[C@H]1C(=O)N(c2ccccc2)c2c(N(C1=O)CC13CC4CC(C3)CC(C1)C4)cccc2)Nc1ccccc1 | 10.1016/S0960-894X(96)00544-6 | |||
CHEMBL329305 | 8674 | 16 | None | -1174 | 2 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 534 | 5 | 2 | 3 | 6.1 | O=C(N[C@H]1C(=O)N(c2ccccc2)c2c(N(C1=O)CC13CC4CC(C3)CC(C1)C4)cccc2)Nc1ccccc1 | 10.1016/S0960-894X(96)00544-6 | |||
44346296 | 121275 | 0 | None | -1174 | 2 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 562 | 6 | 2 | 4 | 5.9 | O=Cc1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 | 10.1021/jm990967h | |||
CHEMBL333517 | 121275 | 0 | None | -1174 | 2 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 562 | 6 | 2 | 4 | 5.9 | O=Cc1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 | 10.1021/jm990967h | |||
11527738 | 82764 | 0 | None | -10964 | 4 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 518 | 7 | 2 | 5 | 5.2 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm051219x | |||
CHEMBL205455 | 82764 | 0 | None | -10964 | 4 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 518 | 7 | 2 | 5 | 5.2 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm051219x | |||
10257865 | 215217 | 4 | None | -173 | 5 | Guinea pig | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 591 | 10 | 3 | 4 | 5.8 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccc(Cl)cc1)CC(=O)O | 10.1021/jm00072a005 | |||
CHEMBL99939 | 215217 | 4 | None | -173 | 5 | Guinea pig | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 591 | 10 | 3 | 4 | 5.8 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccc(Cl)cc1)CC(=O)O | 10.1021/jm00072a005 | |||
10576324 | 120741 | 0 | None | -54 | 2 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 470 | 6 | 2 | 3 | 5.3 | CC(C)CC(C)N1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21 | 10.1021/jm990967h | |||
CHEMBL332595 | 120741 | 0 | None | -54 | 2 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 470 | 6 | 2 | 3 | 5.3 | CC(C)CC(C)N1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21 | 10.1021/jm990967h | |||
135529065 | 163794 | 0 | None | -275 | 3 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 588 | 7 | 2 | 7 | 5.2 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nc(=O)o[nH]3)c2)C(=O)N(C2CCCCCC2)c2ccccc21 | 10.1016/j.bmc.2007.12.047 | |||
CHEMBL407340 | 163794 | 0 | None | -275 | 3 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 588 | 7 | 2 | 7 | 5.2 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nc(=O)o[nH]3)c2)C(=O)N(C2CCCCCC2)c2ccccc21 | 10.1016/j.bmc.2007.12.047 | |||
11511721 | 82877 | 0 | None | -194 | 3 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 502 | 7 | 2 | 5 | 5.5 | CNc1cccc(NC(=O)C[C@@H]2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1021/jm051219x | |||
CHEMBL205751 | 82877 | 0 | None | -194 | 3 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 502 | 7 | 2 | 5 | 5.5 | CNc1cccc(NC(=O)C[C@@H]2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1021/jm051219x | |||
10618720 | 200570 | 0 | None | -4 | 2 | Guinea pig | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 363 | 4 | 2 | 2 | 4.5 | O=C(O)c1cc2ccccc2cc1C(=O)NCC12CC3CC(CC(C3)C1)C2 | 10.1021/jm9508907 | |||
CHEMBL52740 | 200570 | 0 | None | -4 | 2 | Guinea pig | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 363 | 4 | 2 | 2 | 4.5 | O=C(O)c1cc2ccccc2cc1C(=O)NCC12CC3CC(CC(C3)C1)C2 | 10.1021/jm9508907 | |||
CHEMBL64605 | 222635 | 7 | None | -1288 | 3 | Guinea pig | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm0000416 | |||||
11635377 | 205588 | 0 | None | 39 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 554 | 7 | 2 | 6 | 6.0 | CC(CNC(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2009.09.064 | |||
CHEMBL583457 | 205588 | 0 | None | 39 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 554 | 7 | 2 | 6 | 6.0 | CC(CNC(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2009.09.064 | |||
44346047 | 120179 | 0 | None | -537 | 2 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 568 | 7 | 2 | 7 | 6.4 | O=C(Nc1cccc(C2N=NN=N2)c1)NC1C(=O)N(CCC2CCCC2)c2ccccc2N(c2ccccc2F)C1=O | 10.1021/jm990967h | |||
CHEMBL331872 | 120179 | 0 | None | -537 | 2 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 568 | 7 | 2 | 7 | 6.4 | O=C(Nc1cccc(C2N=NN=N2)c1)NC1C(=O)N(CCC2CCCC2)c2ccccc2N(c2ccccc2F)C1=O | 10.1021/jm990967h | |||
CHEMBL3351051 | 218314 | 0 | None | -17 | 2 | Guinea pig | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1cccc2ccccc12)NC)C(=O)N(C)[C@@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C | 10.1021/jm00053a022 | |||||
CHEMBL3351053 | 218316 | 0 | None | -426 | 2 | Guinea pig | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1cccc2ccccc12)C(=O)N(C)[C@@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C | 10.1021/jm00053a022 | |||||
44356886 | 35200 | 0 | None | -42 | 2 | Guinea pig | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 757 | 11 | 5 | 5 | 7.3 | O=C(O)c1cc(NC(=O)[C@@H](CC2CCCCC2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm00021a019 | |||
CHEMBL137525 | 35200 | 0 | None | -42 | 2 | Guinea pig | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 757 | 11 | 5 | 5 | 7.3 | O=C(O)c1cc(NC(=O)[C@@H](CC2CCCCC2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm00021a019 | |||
10747345 | 123756 | 0 | None | -6 | 2 | Guinea pig | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 707 | 10 | 4 | 4 | 6.9 | O=C(O)c1ccccc1NC(=O)[C@H](Cc1ccccc1)NC(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC12CC3CC(CC(C3)C1)C2 | 10.1021/jm00021a019 | |||
CHEMBL338728 | 123756 | 0 | None | -6 | 2 | Guinea pig | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 707 | 10 | 4 | 4 | 6.9 | O=C(O)c1ccccc1NC(=O)[C@H](Cc1ccccc1)NC(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC12CC3CC(CC(C3)C1)C2 | 10.1021/jm00021a019 | |||
44329798 | 114326 | 0 | None | -100 | 5 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 610 | 10 | 2 | 4 | 6.5 | CC(Cc1c[nH]c2ccccc12)(C(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccc(Cl)cc1Cl)CC(=O)O | 10.1021/jm00072a005 | |||
CHEMBL318852 | 114326 | 0 | None | -100 | 5 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 610 | 10 | 2 | 4 | 6.5 | CC(Cc1c[nH]c2ccccc12)(C(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccc(Cl)cc1Cl)CC(=O)O | 10.1021/jm00072a005 | |||
11497371 | 77405 | 0 | None | -40 | 3 | Guinea pig | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 525 | 7 | 3 | 3 | 7.4 | Cc1cc(C)c(-c2nc(C(=O)Nc3ccc(C)c(C(=O)O)c3)c(CCC34CC5CC(CC(C5)C3)C4)[nH]2)c(C)c1 | 10.1021/jm0490686 | |||
CHEMBL195007 | 77405 | 0 | None | -40 | 3 | Guinea pig | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 525 | 7 | 3 | 3 | 7.4 | Cc1cc(C)c(-c2nc(C(=O)Nc3ccc(C)c(C(=O)O)c3)c(CCC34CC5CC(CC(C5)C3)C4)[nH]2)c(C)c1 | 10.1021/jm0490686 | |||
10552320 | 124237 | 0 | None | -109 | 2 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 470 | 6 | 2 | 3 | 5.2 | CC(C)C(C)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21 | 10.1021/jm990967h | |||
CHEMBL339879 | 124237 | 0 | None | -109 | 2 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 470 | 6 | 2 | 3 | 5.2 | CC(C)C(C)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21 | 10.1021/jm990967h | |||
10257865 | 215217 | 4 | None | -204 | 5 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 591 | 10 | 3 | 4 | 5.8 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccc(Cl)cc1)CC(=O)O | 10.1021/jm00072a005 | |||
CHEMBL99939 | 215217 | 4 | None | -204 | 5 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 591 | 10 | 3 | 4 | 5.8 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccc(Cl)cc1)CC(=O)O | 10.1021/jm00072a005 | |||
9960432 | 46198 | 5 | None | -12 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 605 | 8 | 3 | 5 | 5.0 | CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C(=O)O)c2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1016/j.bmc.2007.12.047 | |||
CHEMBL147186 | 46198 | 5 | None | -12 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 605 | 8 | 3 | 5 | 5.0 | CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C(=O)O)c2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1016/j.bmc.2007.12.047 | |||
11571140 | 78476 | 0 | None | -23 | 3 | Guinea pig | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 489 | 7 | 3 | 3 | 6.9 | O=C(O)c1cccc(NC(=O)c2[nH]c(C3CCCCCC3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 | 10.1021/jm0490686 | |||
CHEMBL196517 | 78476 | 0 | None | -23 | 3 | Guinea pig | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 489 | 7 | 3 | 3 | 6.9 | O=C(O)c1cccc(NC(=O)c2[nH]c(C3CCCCCC3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 | 10.1021/jm0490686 | |||
45487002 | 204368 | 0 | None | -10 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 672 | 8 | 3 | 7 | 5.1 | O=C(N[C@@H](Cc1ccc(Cl)c(Br)c1)C(=O)O)c1ccc(Br)cc1NS(=O)(=O)c1cccc2nsnc12 | 10.1016/j.bmcl.2009.09.065 | |||
CHEMBL570520 | 204368 | 0 | None | -10 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 672 | 8 | 3 | 7 | 5.1 | O=C(N[C@@H](Cc1ccc(Cl)c(Br)c1)C(=O)O)c1ccc(Br)cc1NS(=O)(=O)c1cccc2nsnc12 | 10.1016/j.bmcl.2009.09.065 | |||
9958214 | 121571 | 0 | None | -269 | 2 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 517 | 7 | 2 | 4 | 5.1 | CC(C)CCN1C(=O)C(NC(=O)Nc2cccc(N(C)C)c2)C(=O)N(c2ccccc2F)c2ccccc21 | 10.1021/jm990967h | |||
CHEMBL333979 | 121571 | 0 | None | -269 | 2 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 517 | 7 | 2 | 4 | 5.1 | CC(C)CCN1C(=O)C(NC(=O)Nc2cccc(N(C)C)c2)C(=O)N(c2ccccc2F)c2ccccc21 | 10.1021/jm990967h | |||
44272156 | 148320 | 0 | None | -45 | 2 | Guinea pig | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 1194 | 24 | 13 | 13 | 2.6 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00126a007 | |||
CHEMBL384731 | 148320 | 0 | None | -45 | 2 | Guinea pig | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 1194 | 24 | 13 | 13 | 2.6 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00126a007 | |||
44444933 | 101443 | 0 | None | - | 1 | Guinea pig | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 455 | 6 | 3 | 3 | 5.8 | O=C(O)c1cccc(NC(=O)c2nc(-c3ccccc3)[nH]c2CC23CC4CC(CC(C4)C2)C3)c1 | 10.1021/jm070880t | |||
CHEMBL252559 | 101443 | 0 | None | - | 1 | Guinea pig | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 455 | 6 | 3 | 3 | 5.8 | O=C(O)c1cccc(NC(=O)c2nc(-c3ccccc3)[nH]c2CC23CC4CC(CC(C4)C2)C3)c1 | 10.1021/jm070880t | |||
9853208 | 108501 | 0 | None | -1071 | 2 | Guinea pig | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 710 | 11 | 6 | 9 | 4.5 | O=C(NCC12CC3CC(CC(C3)C1)C2)c1cc2[nH]ccc2cc1C(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1cc(-c2nn[nH]n2)cc(-c2nn[nH]n2)c1 | 10.1021/jm9508907 | |||
CHEMBL299540 | 108501 | 0 | None | -1071 | 2 | Guinea pig | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 710 | 11 | 6 | 9 | 4.5 | O=C(NCC12CC3CC(CC(C3)C1)C2)c1cc2[nH]ccc2cc1C(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1cc(-c2nn[nH]n2)cc(-c2nn[nH]n2)c1 | 10.1021/jm9508907 | |||
44346825 | 121551 | 0 | None | -77 | 2 | Guinea pig | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 623 | 8 | 3 | 4 | 4.7 | C[C@@H](NC(=O)C[C@@H]1CCCN1C(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC1C2CC3CC(C2)CC1C3)C(=O)O | 10.1021/jm00048a001 | |||
CHEMBL333920 | 121551 | 0 | None | -77 | 2 | Guinea pig | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 623 | 8 | 3 | 4 | 4.7 | C[C@@H](NC(=O)C[C@@H]1CCCN1C(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC1C2CC3CC(C2)CC1C3)C(=O)O | 10.1021/jm00048a001 | |||
3960 | 9124 | 23 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 458 | 14 | 2 | 3 | 5.2 | CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCCC | 10.1021/jm950423p | |||
891 | 9124 | 23 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 458 | 14 | 2 | 3 | 5.2 | CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCCC | 10.1021/jm950423p | |||
CHEMBL24938 | 9124 | 23 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 458 | 14 | 2 | 3 | 5.2 | CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCCC | 10.1021/jm950423p | |||
16100406 | 89999 | 0 | None | -33 | 4 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 1132 | 28 | 13 | 13 | 1.7 | CCCC[C@@H](NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1cc2ccccc2[nH]1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm061268p | |||
CHEMBL218600 | 89999 | 0 | None | -33 | 4 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 1132 | 28 | 13 | 13 | 1.7 | CCCC[C@@H](NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1cc2ccccc2[nH]1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm061268p | |||
11612498 | 140340 | 0 | None | -5 | 3 | Guinea pig | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 469 | 7 | 3 | 3 | 6.2 | O=C(O)c1cccc(NC(=O)c2[nH]c(-c3ccccc3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 | 10.1021/jm0490686 | |||
CHEMBL371068 | 140340 | 0 | None | -5 | 3 | Guinea pig | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 469 | 7 | 3 | 3 | 6.2 | O=C(O)c1cccc(NC(=O)c2[nH]c(-c3ccccc3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 | 10.1021/jm0490686 | |||
9808153 | 119451 | 0 | None | -36 | 2 | Guinea pig | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 571 | 11 | 3 | 4 | 5.6 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCC(=O)O)CCc1ccccc1 | 10.1021/jm00072a005 | |||
CHEMBL330390 | 119451 | 0 | None | -36 | 2 | Guinea pig | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 571 | 11 | 3 | 4 | 5.6 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCC(=O)O)CCc1ccccc1 | 10.1021/jm00072a005 | |||
10676550 | 126140 | 0 | None | -12 | 2 | Guinea pig | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 751 | 11 | 5 | 5 | 6.6 | O=C(O)c1ccc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc1C(=O)O | 10.1021/jm00021a019 | |||
CHEMBL344396 | 126140 | 0 | None | -12 | 2 | Guinea pig | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 751 | 11 | 5 | 5 | 6.6 | O=C(O)c1ccc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc1C(=O)O | 10.1021/jm00021a019 | |||
10257865 | 215217 | 4 | None | -204 | 5 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 591 | 10 | 3 | 4 | 5.8 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccc(Cl)cc1)CC(=O)O | 10.1021/jm00072a005 | |||
CHEMBL99939 | 215217 | 4 | None | -204 | 5 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 591 | 10 | 3 | 4 | 5.8 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccc(Cl)cc1)CC(=O)O | 10.1021/jm00072a005 | |||
44271859 | 148303 | 0 | None | -4 | 2 | Guinea pig | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 1292 | 39 | 14 | 16 | 2.0 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)CC[C@@H](NC(=O)OC(C)(C)C)C(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00126a007 | |||
CHEMBL384618 | 148303 | 0 | None | -4 | 2 | Guinea pig | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 1292 | 39 | 14 | 16 | 2.0 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)CC[C@@H](NC(=O)OC(C)(C)C)C(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00126a007 | |||
CHEMBL1172251 | 215362 | 0 | None | -229 | 4 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/j.bmcl.2010.05.078 | |||||
CHEMBL3351058 | 218319 | 0 | None | -83 | 2 | Guinea pig | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | None | None | None | CC(C)(C)OC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1cccc2ccccc12)C1CCCCC1 | 10.1021/jm00053a022 | |||||
44265978 | 214279 | 0 | None | - | 1 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 365 | 6 | 2 | 2 | 5.3 | O=C(NCCN(c1ccccc1)c1ccccc1)Nc1ccc(Cl)cc1 | 10.1021/jm00084a009 | |||
CHEMBL9444 | 214279 | 0 | None | - | 1 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 365 | 6 | 2 | 2 | 5.3 | O=C(NCCN(c1ccccc1)c1ccccc1)Nc1ccc(Cl)cc1 | 10.1021/jm00084a009 | |||
CHEMBL2370437 | 216629 | 0 | None | -10 | 2 | Guinea pig | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | None | None | None | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00174a016 | |||||
10745516 | 21129 | 0 | None | -60 | 2 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 563 | 5 | 2 | 4 | 5.8 | CN(C)c1cccc(NC(=O)NC2C(=O)N(c3ccccc3)c3ccccc3N(C3[C@H]4C[C@@H]5C[C@@H](C[C@H]3C5)C4)C2=O)c1 | 10.1021/jm990967h | |||
CHEMBL120015 | 21129 | 0 | None | -60 | 2 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 563 | 5 | 2 | 4 | 5.8 | CN(C)c1cccc(NC(=O)NC2C(=O)N(c3ccccc3)c3ccccc3N(C3[C@H]4C[C@@H]5C[C@@H](C[C@H]3C5)C4)C2=O)c1 | 10.1021/jm990967h | |||
56673524 | 70929 | 0 | None | - | 1 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 589 | 7 | 2 | 5 | 4.2 | O=C(Nc1ccc(F)cc1)NC1C(=O)N(CCN2CCOCC2)c2ccccc2N(CC23CC4CC(CC(C4)C2)C3)C1=O | 10.1016/j.bmc.2011.05.057 | |||
CHEMBL1808418 | 70929 | 0 | None | - | 1 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 589 | 7 | 2 | 5 | 4.2 | O=C(Nc1ccc(F)cc1)NC1C(=O)N(CCN2CCOCC2)c2ccccc2N(CC23CC4CC(CC(C4)C2)C3)C1=O | 10.1016/j.bmc.2011.05.057 | |||
44331467 | 114230 | 0 | None | -41 | 2 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 529 | 7 | 1 | 4 | 5.8 | CC(C)CCN1C(=O)C(NC(=O)Oc2ccccc2)C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc21 | 10.1016/S0960-894X(96)00544-6 | |||
CHEMBL318291 | 114230 | 0 | None | -41 | 2 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 529 | 7 | 1 | 4 | 5.8 | CC(C)CCN1C(=O)C(NC(=O)Oc2ccccc2)C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc21 | 10.1016/S0960-894X(96)00544-6 | |||
44357057 | 125998 | 0 | None | -446 | 2 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 769 | 11 | 5 | 5 | 6.7 | O=C(O)c1cc(NC(=O)[C@@H](Cc2ccccc2F)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm00021a019 | |||
CHEMBL343367 | 125998 | 0 | None | -446 | 2 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 769 | 11 | 5 | 5 | 6.7 | O=C(O)c1cc(NC(=O)[C@@H](Cc2ccccc2F)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm00021a019 | |||
10794262 | 175407 | 0 | None | -6 | 2 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 645 | 10 | 4 | 4 | 4.8 | O=C(O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC12CC3CC(CC(C3)C1)C2 | 10.1021/jm00021a019 | |||
CHEMBL436175 | 175407 | 0 | None | -6 | 2 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 645 | 10 | 4 | 4 | 4.8 | O=C(O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC12CC3CC(CC(C3)C1)C2 | 10.1021/jm00021a019 | |||
11539356 | 78455 | 0 | None | -69 | 3 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 435 | 7 | 3 | 3 | 5.6 | CC(C)c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 | 10.1021/jm0490686 | |||
CHEMBL196441 | 78455 | 0 | None | -69 | 3 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 435 | 7 | 3 | 3 | 5.6 | CC(C)c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 | 10.1021/jm0490686 | |||
56683506 | 70916 | 0 | None | - | 1 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 511 | 8 | 2 | 5 | 3.1 | CC(C)CCN1C(=O)C(NC(=O)Nc2ccc(F)cc2)C(=O)N(CCN2CCOCC2)c2ccccc21 | 10.1016/j.bmc.2011.05.057 | |||
CHEMBL1808403 | 70916 | 0 | None | - | 1 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 511 | 8 | 2 | 5 | 3.1 | CC(C)CCN1C(=O)C(NC(=O)Nc2ccc(F)cc2)C(=O)N(CCN2CCOCC2)c2ccccc21 | 10.1016/j.bmc.2011.05.057 | |||
19700629 | 70914 | 0 | None | - | 1 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 561 | 8 | 2 | 5 | 4.0 | CC(C)CCN1C(=O)C(NC(=O)Nc2ccc(C(F)(F)F)cc2)C(=O)N(CCN2CCOCC2)c2ccccc21 | 10.1016/j.bmc.2011.05.057 | |||
CHEMBL1808401 | 70914 | 0 | None | - | 1 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 561 | 8 | 2 | 5 | 4.0 | CC(C)CCN1C(=O)C(NC(=O)Nc2ccc(C(F)(F)F)cc2)C(=O)N(CCN2CCOCC2)c2ccccc21 | 10.1016/j.bmc.2011.05.057 | |||
10770670 | 99268 | 0 | None | -301 | 2 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 663 | 11 | 6 | 6 | 4.9 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm9508907 | |||
CHEMBL2067959 | 99268 | 0 | None | -301 | 2 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 663 | 11 | 6 | 6 | 4.9 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm9508907 | |||
CHEMBL24313 | 99268 | 0 | None | -301 | 2 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 663 | 11 | 6 | 6 | 4.9 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm9508907 | |||
9850043 | 119650 | 2 | None | -446 | 3 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 534 | 5 | 2 | 3 | 6.1 | O=C(Nc1ccccc1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O | 10.1021/jm990967h | |||
CHEMBL330977 | 119650 | 2 | None | -446 | 3 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 534 | 5 | 2 | 3 | 6.1 | O=C(Nc1ccccc1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O | 10.1021/jm990967h | |||
44346826 | 120591 | 0 | None | -69 | 2 | Guinea pig | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 595 | 7 | 3 | 4 | 3.9 | O=C(O)CNC(=O)[C@H]1CCCN1C(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC1C2CC3CC(C2)CC1C3 | 10.1021/jm00048a001 | |||
CHEMBL332510 | 120591 | 0 | None | -69 | 2 | Guinea pig | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 595 | 7 | 3 | 4 | 3.9 | O=C(O)CNC(=O)[C@H]1CCCN1C(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC1C2CC3CC(C2)CC1C3 | 10.1021/jm00048a001 | |||
CHEMBL334114 | 218173 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](C)N | 10.1021/jm0000416 | |||||
CHEMBL2372623 | 217056 | 0 | None | -16 | 4 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/j.bmcl.2010.05.078 | |||||
CHEMBL2370598 | 216657 | 0 | None | -12 | 2 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCCNC(=O)C[C@@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc2ccc(OS(=O)(=O)O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/jm00126a007 | |||||
44385472 | 88901 | 0 | None | - | 1 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 1246 | 26 | 13 | 15 | 2.2 | CCCC[C@H](NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CCCCNC(=O)CC(NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc2ccc(OS(=O)(=O)O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](CN)Cc1ccccc1 | 10.1021/jm00389a002 | |||
CHEMBL216677 | 88901 | 0 | None | - | 1 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 1246 | 26 | 13 | 15 | 2.2 | CCCC[C@H](NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CCCCNC(=O)CC(NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc2ccc(OS(=O)(=O)O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](CN)Cc1ccccc1 | 10.1021/jm00389a002 | |||
19700643 | 70793 | 0 | None | - | 1 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 505 | 9 | 2 | 4 | 4.5 | CCN(CC)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(CC2CCCCC2)c2ccccc21 | 10.1016/j.bmc.2011.05.057 | |||
CHEMBL1807152 | 70793 | 0 | None | - | 1 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 505 | 9 | 2 | 4 | 4.5 | CCN(CC)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(CC2CCCCC2)c2ccccc21 | 10.1016/j.bmc.2011.05.057 | |||
11712880 | 145701 | 0 | None | -114 | 3 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 490 | 6 | 2 | 5 | 5.2 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(O)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm051219x | |||
CHEMBL378388 | 145701 | 0 | None | -114 | 3 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 490 | 6 | 2 | 5 | 5.2 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(O)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm051219x | |||
10769748 | 119784 | 0 | None | -1148 | 2 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 591 | 6 | 3 | 4 | 6.1 | CC(=O)Nc1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 | 10.1021/jm990967h | |||
CHEMBL331119 | 119784 | 0 | None | -1148 | 2 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 591 | 6 | 3 | 4 | 6.1 | CC(=O)Nc1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 | 10.1021/jm990967h | |||
10482868 | 114181 | 0 | None | -107 | 5 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 557 | 10 | 3 | 4 | 5.2 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccc1)CC(=O)O | 10.1021/jm00072a005 | |||
CHEMBL317999 | 114181 | 0 | None | -107 | 5 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 557 | 10 | 3 | 4 | 5.2 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccc1)CC(=O)O | 10.1021/jm00072a005 | |||
10460621 | 113955 | 0 | None | -8 | 2 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 567 | 8 | 3 | 3 | 6.7 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccc(Cl)c(Cl)c1 | 10.1021/jm00072a005 | |||
CHEMBL316462 | 113955 | 0 | None | -8 | 2 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 567 | 8 | 3 | 3 | 6.7 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccc(Cl)c(Cl)c1 | 10.1021/jm00072a005 | |||
44451877 | 102756 | 0 | None | -162 | 3 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 587 | 7 | 1 | 6 | 6.9 | Cc1nc(-c2cccc(NC(=O)CN3C(=O)N(CC(=O)C(C)(C)C)c4ccccc4N(C4CCCCC4)C3=O)c2)cs1 | 10.1016/j.bmc.2007.12.047 | |||
CHEMBL259557 | 102756 | 0 | None | -162 | 3 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 587 | 7 | 1 | 6 | 6.9 | Cc1nc(-c2cccc(NC(=O)CN3C(=O)N(CC(=O)C(C)(C)C)c4ccccc4N(C4CCCCC4)C3=O)c2)cs1 | 10.1016/j.bmc.2007.12.047 | |||
10722460 | 21964 | 0 | None | -309 | 2 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 612 | 5 | 2 | 3 | 6.9 | O=C(Nc1cccc(Br)c1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O | 10.1021/jm990967h | |||
CHEMBL121028 | 21964 | 0 | None | -309 | 2 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 612 | 5 | 2 | 3 | 6.9 | O=C(Nc1cccc(Br)c1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O | 10.1021/jm990967h | |||
CHEMBL440259 | 220641 | 0 | None | -4 | 2 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@@H](CCC(=O)O)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00126a007 | |||||
44318341 | 212778 | 0 | None | -501 | 3 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 698 | 10 | 5 | 5 | 5.4 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccc(N)c(I)c1 | 10.1016/0960-894X(95)00435-V | |||
CHEMBL1628582 | 212778 | 0 | None | -501 | 3 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 698 | 10 | 5 | 5 | 5.4 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccc(N)c(I)c1 | 10.1016/0960-894X(95)00435-V | |||
CHEMBL84864 | 212778 | 0 | None | -501 | 3 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 698 | 10 | 5 | 5 | 5.4 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccc(N)c(I)c1 | 10.1016/0960-894X(95)00435-V | |||
10698109 | 114073 | 0 | None | 5 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 560 | 8 | 1 | 4 | 5.8 | CC(C)N(C(=O)CN1C(=O)C(CC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1016/j.bmc.2007.12.047 | |||
CHEMBL317181 | 114073 | 0 | None | 5 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 560 | 8 | 1 | 4 | 5.8 | CC(C)N(C(=O)CN1C(=O)C(CC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1016/j.bmc.2007.12.047 | |||
45486967 | 204202 | 0 | None | 39 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 472 | 7 | 2 | 6 | 4.1 | O=C(NCCc1ccccc1)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 | 10.1016/j.bmcl.2009.09.064 | |||
CHEMBL569616 | 204202 | 0 | None | 39 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 472 | 7 | 2 | 6 | 4.1 | O=C(NCCc1ccccc1)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 | 10.1016/j.bmcl.2009.09.064 | |||
45102806 | 203542 | 0 | None | -15 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 646 | 8 | 3 | 7 | 5.1 | O=C(N[C@@H](Cc1ccc(F)c(Br)c1)C(=O)O)c1cc(Cl)c(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 | 10.1016/j.bmcl.2009.09.065 | |||
CHEMBL565324 | 203542 | 0 | None | -15 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 646 | 8 | 3 | 7 | 5.1 | O=C(N[C@@H](Cc1ccc(F)c(Br)c1)C(=O)O)c1cc(Cl)c(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 | 10.1016/j.bmcl.2009.09.065 | |||
45486936 | 203750 | 0 | None | -25 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 640 | 8 | 3 | 6 | 5.1 | O=C(N[C@@H](Cc1ccc(F)c(Br)c1)C(=O)O)c1cc(Cl)c(Cl)cc1NS(=O)(=O)c1cccc2nccnc12 | 10.1016/j.bmcl.2009.09.065 | |||
CHEMBL566574 | 203750 | 0 | None | -25 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 640 | 8 | 3 | 6 | 5.1 | O=C(N[C@@H](Cc1ccc(F)c(Br)c1)C(=O)O)c1cc(Cl)c(Cl)cc1NS(=O)(=O)c1cccc2nccnc12 | 10.1016/j.bmcl.2009.09.065 | |||
11700410 | 205534 | 0 | None | -31 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 704 | 8 | 3 | 7 | 4.4 | O=C(N[C@@H](Cc1ccc(F)c(Br)c1)C(=O)O)c1ccc(I)cc1NS(=O)(=O)c1cccc2nsnc12 | 10.1016/j.bmcl.2009.09.065 | |||
CHEMBL583035 | 205534 | 0 | None | -31 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 704 | 8 | 3 | 7 | 4.4 | O=C(N[C@@H](Cc1ccc(F)c(Br)c1)C(=O)O)c1ccc(I)cc1NS(=O)(=O)c1cccc2nsnc12 | 10.1016/j.bmcl.2009.09.065 | |||
9872866 | 70927 | 0 | None | - | 1 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 571 | 7 | 2 | 5 | 4.1 | O=C(Nc1ccccc1)NC1C(=O)N(CCN2CCOCC2)c2ccccc2N(CC23CC4CC(CC(C4)C2)C3)C1=O | 10.1016/j.bmc.2011.05.057 | |||
CHEMBL1808416 | 70927 | 0 | None | - | 1 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 571 | 7 | 2 | 5 | 4.1 | O=C(Nc1ccccc1)NC1C(=O)N(CCN2CCOCC2)c2ccccc2N(CC23CC4CC(CC(C4)C2)C3)C1=O | 10.1016/j.bmc.2011.05.057 | |||
44212230 | 11032 | 0 | None | -208 | 2 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 572 | 8 | 1 | 5 | 5.9 | CC(C)CCN1C(=O)C(NC(=O)Oc2cccc(N(C)C)c2)C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc21 | 10.1016/S0960-894X(96)00544-6 | |||
CHEMBL100509 | 11032 | 0 | None | -208 | 2 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 572 | 8 | 1 | 5 | 5.9 | CC(C)CCN1C(=O)C(NC(=O)Oc2cccc(N(C)C)c2)C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc21 | 10.1016/S0960-894X(96)00544-6 | |||
10792765 | 119857 | 0 | None | -2754 | 2 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 550 | 5 | 3 | 4 | 5.8 | O=C(Nc1cccc(O)c1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O | 10.1021/jm990967h | |||
CHEMBL331244 | 119857 | 0 | None | -2754 | 2 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 550 | 5 | 3 | 4 | 5.8 | O=C(Nc1cccc(O)c1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O | 10.1021/jm990967h | |||
10770670 | 99268 | 0 | None | -301 | 2 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 663 | 11 | 6 | 6 | 4.9 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm049069y | |||
CHEMBL2067959 | 99268 | 0 | None | -301 | 2 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 663 | 11 | 6 | 6 | 4.9 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm049069y | |||
CHEMBL24313 | 99268 | 0 | None | -301 | 2 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 663 | 11 | 6 | 6 | 4.9 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm049069y | |||
44359447 | 21475 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 1031 | 30 | 11 | 11 | 1.0 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCCC)NC(=O)[C@@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00122a026 | |||
CHEMBL1206132 | 21475 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 1031 | 30 | 11 | 11 | 1.0 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCCC)NC(=O)[C@@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00122a026 | |||
CHEMBL217767 | 21475 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 1031 | 30 | 11 | 11 | 1.0 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCCC)NC(=O)[C@@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00122a026 | |||
CHEMBL216831 | 216122 | 0 | None | -29 | 2 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCC)NC(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@@H](CCC(=O)O)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00126a007 | |||||
10482233 | 174981 | 0 | None | -41 | 2 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 533 | 8 | 3 | 3 | 6.0 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccc(Cl)cc1 | 10.1021/jm00072a005 | |||
CHEMBL433407 | 174981 | 0 | None | -41 | 2 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 533 | 8 | 3 | 3 | 6.0 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccc(Cl)cc1 | 10.1021/jm00072a005 | |||
10795116 | 34688 | 0 | None | -602 | 2 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 743 | 11 | 5 | 5 | 6.7 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCc2ccc3ccccc3c2)cc(C(=O)O)c1 | 10.1021/jm00021a019 | |||
CHEMBL137180 | 34688 | 0 | None | -602 | 2 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 743 | 11 | 5 | 5 | 6.7 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCc2ccc3ccccc3c2)cc(C(=O)O)c1 | 10.1021/jm00021a019 | |||
9850043 | 119650 | 2 | None | -446 | 3 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 534 | 5 | 2 | 3 | 6.1 | O=C(Nc1ccccc1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O | 10.1021/jm990967h | |||
CHEMBL330977 | 119650 | 2 | None | -446 | 3 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 534 | 5 | 2 | 3 | 6.1 | O=C(Nc1ccccc1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O | 10.1021/jm990967h | |||
52949124 | 7663 | 4 | None | -2 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
9055 | 7663 | 4 | None | -2 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
CHEMBL1269258 | 7663 | 4 | None | -2 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
DB12694 | 7663 | 4 | None | -2 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
44356826 | 126084 | 0 | None | -19 | 2 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 781 | 12 | 5 | 6 | 6.6 | COc1ccc(C[C@@H](NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)C(=O)Nc2cc(C(=O)O)cc(C(=O)O)c2)cc1 | 10.1021/jm00021a019 | |||
CHEMBL344014 | 126084 | 0 | None | -19 | 2 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 781 | 12 | 5 | 6 | 6.6 | COc1ccc(C[C@@H](NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)C(=O)Nc2cc(C(=O)O)cc(C(=O)O)c2)cc1 | 10.1021/jm00021a019 | |||
56666598 | 70933 | 0 | None | - | 1 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 575 | 9 | 2 | 4 | 5.3 | CCN(CC)CCN1C(=O)C(NC(=O)Nc2ccc(F)cc2)C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc21 | 10.1016/j.bmc.2011.05.057 | |||
CHEMBL1808422 | 70933 | 0 | None | - | 1 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 575 | 9 | 2 | 4 | 5.3 | CCN(CC)CCN1C(=O)C(NC(=O)Nc2ccc(F)cc2)C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc21 | 10.1016/j.bmc.2011.05.057 | |||
16733645 | 19953 | 0 | None | -416 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 598 | 9 | 2 | 7 | 5.4 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3cn(CC(=O)O)cn3)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
CHEMBL1190962 | 19953 | 0 | None | -416 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 598 | 9 | 2 | 7 | 5.4 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3cn(CC(=O)O)cn3)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
CHEMBL541903 | 19953 | 0 | None | -416 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 598 | 9 | 2 | 7 | 5.4 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3cn(CC(=O)O)cn3)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
44280114 | 11882 | 0 | None | 1 | 2 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 567 | 7 | 2 | 4 | 6.1 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1CCC(C(=O)c2ccccc2)CC1 | 10.1016/s0960-894x(98)00231-5 | |||
CHEMBL105618 | 11882 | 0 | None | 1 | 2 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 567 | 7 | 2 | 4 | 6.1 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1CCC(C(=O)c2ccccc2)CC1 | 10.1016/s0960-894x(98)00231-5 | |||
44572200 | 186122 | 0 | None | -14 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 510 | 3 | 2 | 3 | 4.3 | CN1C(=O)[C@@H](NC(=O)Nc2cccc(I)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm801439x | |||
CHEMBL473612 | 186122 | 0 | None | -14 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 510 | 3 | 2 | 3 | 4.3 | CN1C(=O)[C@@H](NC(=O)Nc2cccc(I)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm801439x | |||
CHEMBL475226 | 186122 | 0 | None | -14 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 510 | 3 | 2 | 3 | 4.3 | CN1C(=O)[C@@H](NC(=O)Nc2cccc(I)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm801439x | |||
56659685 | 70926 | 0 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 533 | 7 | 2 | 5 | 3.8 | Cc1cccc(NC(=O)NC2C(=O)N(CCN3CCOCC3)c3ccccc3N(CC3CCCCC3)C2=O)c1 | 10.1016/j.bmc.2011.05.057 | |||
CHEMBL1808415 | 70926 | 0 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 533 | 7 | 2 | 5 | 3.8 | Cc1cccc(NC(=O)NC2C(=O)N(CCN3CCOCC3)c3ccccc3N(CC3CCCCC3)C2=O)c1 | 10.1016/j.bmc.2011.05.057 | |||
5311201 | 214174 | 35 | None | -1174 | 6 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm051219x | |||
CHEMBL9387 | 214174 | 35 | None | -1174 | 6 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm051219x | |||
16732019 | 92209 | 0 | None | -1737 | 4 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 542 | 7 | 2 | 7 | 4.6 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nn[nH]n3)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
CHEMBL226533 | 92209 | 0 | None | -1737 | 4 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 542 | 7 | 2 | 7 | 4.6 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nn[nH]n3)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
54045469 | 70923 | 0 | None | - | 1 | Rat | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 481 | 9 | 2 | 5 | 3.2 | COc1ccc(NC(=O)NC2C(=O)N(CCC(C)C)c3ccccc3N(CCN(C)C)C2=O)cc1 | 10.1016/j.bmc.2011.05.057 | |||
CHEMBL1808412 | 70923 | 0 | None | - | 1 | Rat | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 481 | 9 | 2 | 5 | 3.2 | COc1ccc(NC(=O)NC2C(=O)N(CCC(C)C)c3ccccc3N(CCN(C)C)C2=O)cc1 | 10.1016/j.bmc.2011.05.057 | |||
10258121 | 105349 | 0 | None | 11 | 2 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 606 | 11 | 4 | 2 | 7.1 | CC(Cc1c[nH]c2ccccc12)(NC(=O)NC(c1ccccc1)(c1ccccc1)c1ccccc1)C(=O)NCCc1ccccc1 | 10.1021/jm00072a005 | |||
CHEMBL276676 | 105349 | 0 | None | 11 | 2 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 606 | 11 | 4 | 2 | 7.1 | CC(Cc1c[nH]c2ccccc12)(NC(=O)NC(c1ccccc1)(c1ccccc1)c1ccccc1)C(=O)NCCc1ccccc1 | 10.1021/jm00072a005 | |||
CHEMBL59865 | 222595 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN | 10.1021/jm0000416 | |||||
CHEMBL1172253 | 215364 | 0 | None | -138 | 4 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/j.bmcl.2010.05.078 | |||||
44265911 | 213912 | 0 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 276 | 4 | 2 | 1 | 3.6 | O=C(NC/C=C/c1ccccc1)c1cc2ccccc2[nH]1 | 10.1021/jm00084a009 | |||
CHEMBL9220 | 213912 | 0 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 276 | 4 | 2 | 1 | 3.6 | O=C(NC/C=C/c1ccccc1)c1cc2ccccc2[nH]1 | 10.1021/jm00084a009 | |||
10004216 | 11515 | 0 | None | -11 | 2 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 456 | 6 | 2 | 3 | 4.9 | CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21 | 10.1021/jm990967h | |||
CHEMBL103750 | 11515 | 0 | None | -11 | 2 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 456 | 6 | 2 | 3 | 4.9 | CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21 | 10.1021/jm990967h | |||
44356887 | 38091 | 0 | None | -776 | 2 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 757 | 11 | 5 | 6 | 6.7 | O=C(O)c1cc(NC(=O)[C@@H](Cc2ccsc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm00021a019 | |||
CHEMBL140179 | 38091 | 0 | None | -776 | 2 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 757 | 11 | 5 | 6 | 6.7 | O=C(O)c1cc(NC(=O)[C@@H](Cc2ccsc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm00021a019 | |||
10323690 | 107274 | 0 | None | -21 | 2 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 499 | 8 | 3 | 3 | 5.4 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccc1 | 10.1021/jm00072a005 | |||
CHEMBL2114401 | 107274 | 0 | None | -21 | 2 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 499 | 8 | 3 | 3 | 5.4 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccc1 | 10.1021/jm00072a005 | |||
CHEMBL291033 | 107274 | 0 | None | -21 | 2 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 499 | 8 | 3 | 3 | 5.4 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccc1 | 10.1021/jm00072a005 | |||
44272076 | 175588 | 0 | None | -407 | 2 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 1194 | 24 | 13 | 13 | 2.6 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCCNC(=O)[C@H](NC(=O)OC(C)(C)C)CCC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/jm00126a007 | |||
CHEMBL437661 | 175588 | 0 | None | -407 | 2 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 1194 | 24 | 13 | 13 | 2.6 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCCNC(=O)[C@H](NC(=O)OC(C)(C)C)CCC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/jm00126a007 | |||
10819816 | 125519 | 0 | None | 7 | 2 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 998 | 28 | 10 | 13 | 0.4 | CSCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm970477u | |||
CHEMBL341762 | 125519 | 0 | None | 7 | 2 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 998 | 28 | 10 | 13 | 0.4 | CSCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm970477u | |||
73354497 | 96160 | 0 | None | 7 | 2 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 998 | 28 | 10 | 13 | 0.4 | CSCC[C@@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCSC)C(=O)N[C@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm990252e | |||
CHEMBL2369817 | 96160 | 0 | None | 7 | 2 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 998 | 28 | 10 | 13 | 0.4 | CSCC[C@@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCSC)C(=O)N[C@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm990252e | |||
44359447 | 21475 | 0 | None | - | 1 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 1031 | 30 | 11 | 11 | 1.0 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCCC)NC(=O)[C@@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00122a026 | |||
CHEMBL1206132 | 21475 | 0 | None | - | 1 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 1031 | 30 | 11 | 11 | 1.0 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCCC)NC(=O)[C@@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00122a026 | |||
CHEMBL217767 | 21475 | 0 | None | - | 1 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 1031 | 30 | 11 | 11 | 1.0 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCCC)NC(=O)[C@@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00122a026 | |||
10768579 | 120643 | 0 | None | -32 | 2 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 531 | 6 | 2 | 4 | 5.5 | CN(C)c1cccc(NC(=O)NC2C(=O)N(CCC(C)(C)C)c3ccccc3N(c3ccccc3F)C2=O)c1 | 10.1021/jm990967h | |||
CHEMBL332568 | 120643 | 0 | None | -32 | 2 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 531 | 6 | 2 | 4 | 5.5 | CN(C)c1cccc(NC(=O)NC2C(=O)N(CCC(C)(C)C)c3ccccc3N(c3ccccc3F)C2=O)c1 | 10.1021/jm990967h | |||
53465844 | 76186 | 0 | None | 131 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 441 | 8 | 4 | 3 | 4.2 | O=C(Nc1ccccc1C(=O)N[C@H](CCc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 | 10.1021/jm200438b | |||
CHEMBL1933104 | 76186 | 0 | None | 131 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 441 | 8 | 4 | 3 | 4.2 | O=C(Nc1ccccc1C(=O)N[C@H](CCc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 | 10.1021/jm200438b | |||
10722460 | 21964 | 0 | None | -309 | 2 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 612 | 5 | 2 | 3 | 6.9 | O=C(Nc1cccc(Br)c1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O | 10.1021/jm990967h | |||
CHEMBL121028 | 21964 | 0 | None | -309 | 2 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 612 | 5 | 2 | 3 | 6.9 | O=C(Nc1cccc(Br)c1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O | 10.1021/jm990967h | |||
44408526 | 143723 | 0 | None | -2344 | 4 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 1148 | 30 | 11 | 15 | 3.0 | CCCC[C@@H](C(=O)N[C@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)C(=O)O)N(C)C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O | 10.1021/jm050851n | |||
CHEMBL374325 | 143723 | 0 | None | -2344 | 4 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 1148 | 30 | 11 | 15 | 3.0 | CCCC[C@@H](C(=O)N[C@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)C(=O)O)N(C)C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O | 10.1021/jm050851n | |||
16100409 | 90009 | 0 | None | -870 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 1031 | 27 | 13 | 12 | 0.2 | CCCC[C@@H](NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](N)Cc1ccccc1)C(=O)N[C@@H](Cc1cc2ccccc2[nH]1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm061268p | |||
CHEMBL218651 | 90009 | 0 | None | -870 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 1031 | 27 | 13 | 12 | 0.2 | CCCC[C@@H](NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](N)Cc1ccccc1)C(=O)N[C@@H](Cc1cc2ccccc2[nH]1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm061268p | |||
16732916 | 143731 | 0 | None | -338 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 596 | 8 | 2 | 5 | 6.3 | O=C(CN1N=C(C2CCCCC2)c2ccccc2N(CC(=O)C23CC4CC(CC(C4)C2)C3)C1=O)Nc1cccc(C(=O)O)c1 | 10.1021/jm070139l | |||
CHEMBL374388 | 143731 | 0 | None | -338 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 596 | 8 | 2 | 5 | 6.3 | O=C(CN1N=C(C2CCCCC2)c2ccccc2N(CC(=O)C23CC4CC(CC(C4)C2)C3)C1=O)Nc1cccc(C(=O)O)c1 | 10.1021/jm070139l | |||
10695854 | 120780 | 0 | None | -25 | 2 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 474 | 6 | 2 | 3 | 5.1 | CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2F)c2ccccc21 | 10.1021/jm990967h | |||
CHEMBL332646 | 120780 | 0 | None | -25 | 2 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 474 | 6 | 2 | 3 | 5.1 | CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2F)c2ccccc21 | 10.1021/jm990967h | |||
45486955 | 204177 | 0 | None | -5 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 628 | 8 | 3 | 7 | 5.0 | O=C(N[C@@H](Cc1ccc(Cl)c(Br)c1)C(=O)O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 | 10.1016/j.bmcl.2009.09.064 | |||
CHEMBL569470 | 204177 | 0 | None | -5 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 628 | 8 | 3 | 7 | 5.0 | O=C(N[C@@H](Cc1ccc(Cl)c(Br)c1)C(=O)O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 | 10.1016/j.bmcl.2009.09.064 | |||
45486969 | 204249 | 0 | None | 7 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 598 | 8 | 3 | 7 | 5.4 | C[C@H](c1ccc(Cl)c(Cl)c1)[C@@H](NC(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)C(=O)O | 10.1016/j.bmcl.2009.09.064 | |||
CHEMBL569849 | 204249 | 0 | None | 7 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 598 | 8 | 3 | 7 | 5.4 | C[C@H](c1ccc(Cl)c(Cl)c1)[C@@H](NC(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)C(=O)O | 10.1016/j.bmcl.2009.09.064 | |||
45486947 | 203681 | 0 | None | 1 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 654 | 8 | 2 | 7 | 5.2 | COC(=O)[C@H](Cc1ccc(F)c(Br)c1)NC(=O)c1cc(Cl)c(Cl)cc1NS(=O)(=O)c1cccc2nccnc12 | 10.1016/j.bmcl.2009.09.065 | |||
CHEMBL566177 | 203681 | 0 | None | 1 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 654 | 8 | 2 | 7 | 5.2 | COC(=O)[C@H](Cc1ccc(F)c(Br)c1)NC(=O)c1cc(Cl)c(Cl)cc1NS(=O)(=O)c1cccc2nccnc12 | 10.1016/j.bmcl.2009.09.065 | |||
11693225 | 205580 | 0 | None | -7 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 676 | 8 | 3 | 7 | 4.8 | O=C(N[C@@H](Cc1ccc(Cl)c(Cl)c1)C(=O)O)c1ccc(I)cc1NS(=O)(=O)c1cccc2nsnc12 | 10.1016/j.bmcl.2009.09.065 | |||
CHEMBL583344 | 205580 | 0 | None | -7 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 676 | 8 | 3 | 7 | 4.8 | O=C(N[C@@H](Cc1ccc(Cl)c(Cl)c1)C(=O)O)c1ccc(I)cc1NS(=O)(=O)c1cccc2nsnc12 | 10.1016/j.bmcl.2009.09.065 | |||
16090700 | 89238 | 0 | None | 10 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 541 | 8 | 4 | 4 | 4.2 | O=C(N[C@@H](Cc1ccccc1)C(=O)O)c1ccc(Br)cc1NS(=O)(=O)c1cc2ccccc2[nH]1 | 10.1021/jm060590x | |||
CHEMBL217595 | 89238 | 0 | None | 10 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 541 | 8 | 4 | 4 | 4.2 | O=C(N[C@@H](Cc1ccccc1)C(=O)O)c1ccc(Br)cc1NS(=O)(=O)c1cc2ccccc2[nH]1 | 10.1021/jm060590x | |||
9958214 | 121571 | 0 | None | -269 | 2 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 517 | 7 | 2 | 4 | 5.1 | CC(C)CCN1C(=O)C(NC(=O)Nc2cccc(N(C)C)c2)C(=O)N(c2ccccc2F)c2ccccc21 | 10.1021/jm990967h | |||
CHEMBL333979 | 121571 | 0 | None | -269 | 2 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 517 | 7 | 2 | 4 | 5.1 | CC(C)CCN1C(=O)C(NC(=O)Nc2cccc(N(C)C)c2)C(=O)N(c2ccccc2F)c2ccccc21 | 10.1021/jm990967h | |||
45486995 | 204580 | 0 | None | -1 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 486 | 8 | 2 | 6 | 4.5 | O=C(NCCCc1ccccc1)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 | 10.1016/j.bmcl.2009.09.064 | |||
CHEMBL572046 | 204580 | 0 | None | -1 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 486 | 8 | 2 | 6 | 4.5 | O=C(NCCCc1ccccc1)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 | 10.1016/j.bmcl.2009.09.064 | |||
45486940 | 205664 | 0 | None | -31 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 550 | 8 | 3 | 7 | 4.2 | O=C(N[C@@H](Cc1ccc(Cl)cc1)C(=O)O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 | 10.1016/j.bmcl.2009.09.064 | |||
CHEMBL584259 | 205664 | 0 | None | -31 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 550 | 8 | 3 | 7 | 4.2 | O=C(N[C@@H](Cc1ccc(Cl)cc1)C(=O)O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 | 10.1016/j.bmcl.2009.09.064 | |||
44444929 | 101658 | 0 | None | - | 1 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 788 | 11 | 6 | 5 | 6.1 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccc(I)cc2)NC(=O)c2cc3cc[nH]c3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm070880t | |||
CHEMBL254020 | 101658 | 0 | None | - | 1 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 788 | 11 | 6 | 5 | 6.1 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccc(I)cc2)NC(=O)c2cc3cc[nH]c3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm070880t | |||
10795162 | 125816 | 0 | None | -630 | 2 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 751 | 11 | 5 | 5 | 6.6 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm070880t | |||
CHEMBL2067970 | 125816 | 0 | None | -630 | 2 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 751 | 11 | 5 | 5 | 6.6 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm070880t | |||
CHEMBL342616 | 125816 | 0 | None | -630 | 2 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 751 | 11 | 5 | 5 | 6.6 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm070880t | |||
16090702 | 172977 | 0 | None | 1 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 461 | 4 | 2 | 3 | 4.4 | O=C(c1ccc(Br)cc1NS(=O)(=O)c1cc2ccccc2[nH]1)N1CCCCC1 | 10.1021/jm060590x | |||
CHEMBL426524 | 172977 | 0 | None | 1 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 461 | 4 | 2 | 3 | 4.4 | O=C(c1ccc(Br)cc1NS(=O)(=O)c1cc2ccccc2[nH]1)N1CCCCC1 | 10.1021/jm060590x | |||
44331343 | 11183 | 0 | None | -57 | 2 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 606 | 6 | 2 | 3 | 7.0 | O=C(Nc1ccccc1)NC1C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc2N(CC23CC4CC(CC(C4)C2)C3)C1=O | 10.1016/S0960-894X(96)00544-6 | |||
CHEMBL101456 | 11183 | 0 | None | -57 | 2 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 606 | 6 | 2 | 3 | 7.0 | O=C(Nc1ccccc1)NC1C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc2N(CC23CC4CC(CC(C4)C2)C3)C1=O | 10.1016/S0960-894X(96)00544-6 | |||
44403984 | 19083 | 0 | None | -125 | 2 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 677 | 11 | 5 | 6 | 5.2 | CN(CC12CC3CC(CC(C3)C1)C2)C(=O)c1cc2[nH]cnc2cc1C(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1cc(C(=O)O)cc(C(=O)O)c1 | 10.1021/jm049069y | |||
CHEMBL1185003 | 19083 | 0 | None | -125 | 2 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 677 | 11 | 5 | 6 | 5.2 | CN(CC12CC3CC(CC(C3)C1)C2)C(=O)c1cc2[nH]cnc2cc1C(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1cc(C(=O)O)cc(C(=O)O)c1 | 10.1021/jm049069y | |||
CHEMBL2067967 | 19083 | 0 | None | -125 | 2 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 677 | 11 | 5 | 6 | 5.2 | CN(CC12CC3CC(CC(C3)C1)C2)C(=O)c1cc2[nH]cnc2cc1C(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1cc(C(=O)O)cc(C(=O)O)c1 | 10.1021/jm049069y | |||
10795162 | 125816 | 0 | None | -630 | 2 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 751 | 11 | 5 | 5 | 6.6 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm049069y | |||
CHEMBL2067970 | 125816 | 0 | None | -630 | 2 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 751 | 11 | 5 | 5 | 6.6 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm049069y | |||
CHEMBL342616 | 125816 | 0 | None | -630 | 2 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 751 | 11 | 5 | 5 | 6.6 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm049069y | |||
6956374 | 9184 | 5 | None | - | 1 | Guinea pig | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 435 | 3 | 2 | 2 | 4.9 | Brc1ccc(cc1)NC(=O)N1NC(=O)[C@@H]([C@H]1c1ccccc1)c1ccccc1 | 10.1021/jm070880t | |||
902 | 9184 | 5 | None | - | 1 | Guinea pig | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 435 | 3 | 2 | 2 | 4.9 | Brc1ccc(cc1)NC(=O)N1NC(=O)[C@@H]([C@H]1c1ccccc1)c1ccccc1 | 10.1021/jm070880t | |||
CHEMBL117281 | 9184 | 5 | None | - | 1 | Guinea pig | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 435 | 3 | 2 | 2 | 4.9 | Brc1ccc(cc1)NC(=O)N1NC(=O)[C@@H]([C@H]1c1ccccc1)c1ccccc1 | 10.1021/jm070880t | |||
9939183 | 120905 | 0 | None | -6606 | 2 | Rat | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 633 | 7 | 2 | 5 | 5.9 | O=C(Nc1cccc(CN2CCOCC2)c1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O | 10.1021/jm990967h | |||
CHEMBL332850 | 120905 | 0 | None | -6606 | 2 | Rat | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 633 | 7 | 2 | 5 | 5.9 | O=C(Nc1cccc(CN2CCOCC2)c1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O | 10.1021/jm990967h | |||
44347144 | 119843 | 0 | None | -12 | 2 | Guinea pig | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 512 | 6 | 2 | 4 | 4.0 | COC(=O)CNC(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC1C2CC3CC(C2)CC1C3 | 10.1021/jm00048a001 | |||
CHEMBL331177 | 119843 | 0 | None | -12 | 2 | Guinea pig | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 512 | 6 | 2 | 4 | 4.0 | COC(=O)CNC(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC1C2CC3CC(C2)CC1C3 | 10.1021/jm00048a001 | |||
CHEMBL386304 | 219159 | 0 | None | -6 | 2 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CCC(=O)O)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00126a007 | |||||
44272056 | 104940 | 0 | None | -42 | 2 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 1194 | 24 | 13 | 13 | 2.6 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCCNC(=O)CC[C@@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00126a007 | |||
CHEMBL273880 | 104940 | 0 | None | -42 | 2 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 1194 | 24 | 13 | 13 | 2.6 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCCNC(=O)CC[C@@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00126a007 | |||
10794634 | 119879 | 0 | None | 11220 | 2 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 677 | 19 | 7 | 7 | 0.3 | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(N)=O | 10.1021/jm0000416 | |||
CHEMBL331394 | 119879 | 0 | None | 11220 | 2 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 677 | 19 | 7 | 7 | 0.3 | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(N)=O | 10.1021/jm0000416 | |||
53465844 | 76186 | 0 | None | 131 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 441 | 8 | 4 | 3 | 4.2 | O=C(Nc1ccccc1C(=O)N[C@H](CCc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 | 10.1021/jm200438b | |||
CHEMBL1933104 | 76186 | 0 | None | 131 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 441 | 8 | 4 | 3 | 4.2 | O=C(Nc1ccccc1C(=O)N[C@H](CCc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 | 10.1021/jm200438b | |||
CHEMBL333477 | 218171 | 0 | None | -3 | 3 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C | 10.1016/j.bmcl.2003.11.001 | |||||
CHEMBL333762 | 218172 | 0 | None | - | 1 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@@H](N)Cc1c[nH]c2ccccc12 | 10.1021/jm0000416 | |||||
11216391 | 170272 | 0 | None | 1348 | 2 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 747 | 23 | 7 | 7 | 2.1 | CCCCCNC(=O)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/j.bmcl.2003.11.001 | |||
CHEMBL420161 | 170272 | 0 | None | 1348 | 2 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 747 | 23 | 7 | 7 | 2.1 | CCCCCNC(=O)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/j.bmcl.2003.11.001 | |||
CHEMBL119992 | 215377 | 0 | None | - | 1 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N | 10.1021/jm0000416 | |||||
CHEMBL3350278 | 218245 | 0 | None | 20 | 2 | Guinea pig | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | None | None | None | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(N)=O | 10.1021/jm00174a016 | |||||
44265932 | 103777 | 0 | None | - | 1 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 420 | 5 | 2 | 1 | 6.3 | O=C(NCC=C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)c1cc2ccccc2[nH]1 | 10.1021/jm00084a009 | |||
CHEMBL266596 | 103777 | 0 | None | - | 1 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 420 | 5 | 2 | 1 | 6.3 | O=C(NCC=C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)c1cc2ccccc2[nH]1 | 10.1021/jm00084a009 | |||
44265967 | 171652 | 0 | None | - | 1 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 350 | 11 | 2 | 1 | 6.5 | CCCCCC(=CCNC(=O)Nc1ccc(Cl)cc1)CCCCC | 10.1021/jm00084a009 | |||
CHEMBL422036 | 171652 | 0 | None | - | 1 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 350 | 11 | 2 | 1 | 6.5 | CCCCCC(=CCNC(=O)Nc1ccc(Cl)cc1)CCCCC | 10.1021/jm00084a009 | |||
CHEMBL379405 | 219044 | 0 | None | -11 | 4 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm050921q | |||||
10099504 | 214992 | 0 | None | -14 | 2 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 568 | 10 | 2 | 4 | 5.8 | CC(Cc1cccc2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccc1)CC(=O)O | 10.1021/jm00072a005 | |||
CHEMBL98516 | 214992 | 0 | None | -14 | 2 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 568 | 10 | 2 | 4 | 5.8 | CC(Cc1cccc2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccc1)CC(=O)O | 10.1021/jm00072a005 | |||
10628607 | 123552 | 0 | None | -467 | 2 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 713 | 11 | 5 | 5 | 6.4 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC2CCCCCC2)cc(C(=O)O)c1 | 10.1021/jm00021a019 | |||
CHEMBL337673 | 123552 | 0 | None | -467 | 2 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 713 | 11 | 5 | 5 | 6.4 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC2CCCCCC2)cc(C(=O)O)c1 | 10.1021/jm00021a019 | |||
19700636 | 70921 | 0 | None | - | 1 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 491 | 8 | 2 | 4 | 4.1 | CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(CCN2CCCCC2)c2ccccc21 | 10.1016/j.bmc.2011.05.057 | |||
CHEMBL1808410 | 70921 | 0 | None | - | 1 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 491 | 8 | 2 | 4 | 4.1 | CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(CCN2CCCCC2)c2ccccc21 | 10.1016/j.bmc.2011.05.057 | |||
9872866 | 70927 | 0 | None | - | 1 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 571 | 7 | 2 | 5 | 4.1 | O=C(Nc1ccccc1)NC1C(=O)N(CCN2CCOCC2)c2ccccc2N(CC23CC4CC(CC(C4)C2)C3)C1=O | 10.1016/j.bmc.2011.05.057 | |||
CHEMBL1808416 | 70927 | 0 | None | - | 1 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 571 | 7 | 2 | 5 | 4.1 | O=C(Nc1ccccc1)NC1C(=O)N(CCN2CCOCC2)c2ccccc2N(CC23CC4CC(CC(C4)C2)C3)C1=O | 10.1016/j.bmc.2011.05.057 | |||
19700617 | 70932 | 0 | None | - | 1 | Rat | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 543 | 8 | 2 | 4 | 4.7 | CN(C)CCCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc21 | 10.1016/j.bmc.2011.05.057 | |||
CHEMBL1808421 | 70932 | 0 | None | - | 1 | Rat | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 543 | 8 | 2 | 4 | 4.7 | CN(C)CCCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc21 | 10.1016/j.bmc.2011.05.057 | |||
10370321 | 19754 | 0 | None | -30902 | 2 | Rat | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 550 | 5 | 3 | 4 | 5.8 | O=C(Nc1ccc(O)cc1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O | 10.1021/jm990967h | |||
CHEMBL118954 | 19754 | 0 | None | -30902 | 2 | Rat | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 550 | 5 | 3 | 4 | 5.8 | O=C(Nc1ccc(O)cc1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O | 10.1021/jm990967h | |||
44346909 | 121361 | 0 | None | -10 | 2 | Guinea pig | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 498 | 6 | 3 | 3 | 3.9 | O=C(O)CNC(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC1C2CC3CC(C2)CC1C3 | 10.1021/jm00048a001 | |||
CHEMBL333758 | 121361 | 0 | None | -10 | 2 | Guinea pig | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 498 | 6 | 3 | 3 | 3.9 | O=C(O)CNC(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC1C2CC3CC(C2)CC1C3 | 10.1021/jm00048a001 | |||
44356888 | 125647 | 0 | None | -35 | 2 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 765 | 12 | 5 | 5 | 7.0 | O=C(O)c1cc(NC(=O)[C@@H](CCc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm00021a019 | |||
CHEMBL342205 | 125647 | 0 | None | -35 | 2 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 765 | 12 | 5 | 5 | 7.0 | O=C(O)c1cc(NC(=O)[C@@H](CCc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm00021a019 | |||
10795162 | 125816 | 0 | None | -630 | 2 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 751 | 11 | 5 | 5 | 6.6 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm00021a019 | |||
CHEMBL2067970 | 125816 | 0 | None | -630 | 2 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 751 | 11 | 5 | 5 | 6.6 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm00021a019 | |||
CHEMBL342616 | 125816 | 0 | None | -630 | 2 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 751 | 11 | 5 | 5 | 6.6 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm00021a019 | |||
11561828 | 147405 | 0 | None | -4 | 2 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 468 | 7 | 3 | 2 | 6.8 | O=C(O)c1cccc(NC(=O)c2cc(-c3ccccc3)[nH]c2CCC23CC4CC(CC(C4)C2)C3)c1 | 10.1021/jm0490686 | |||
CHEMBL381426 | 147405 | 0 | None | -4 | 2 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 468 | 7 | 3 | 2 | 6.8 | O=C(O)c1cccc(NC(=O)c2cc(-c3ccccc3)[nH]c2CCC23CC4CC(CC(C4)C2)C3)c1 | 10.1021/jm0490686 | |||
44451547 | 103487 | 0 | None | -489 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 587 | 8 | 2 | 8 | 4.7 | CN(c1cccc(NC(=O)CN2C(=O)N(CC(=O)C(C)(C)C)c3ccccc3N(C3CCCCC3)C2=O)c1)c1nn[nH]n1 | 10.1016/j.bmc.2007.12.047 | |||
CHEMBL264150 | 103487 | 0 | None | -489 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 587 | 8 | 2 | 8 | 4.7 | CN(c1cccc(NC(=O)CN2C(=O)N(CC(=O)C(C)(C)C)c3ccccc3N(C3CCCCC3)C2=O)c1)c1nn[nH]n1 | 10.1016/j.bmc.2007.12.047 | |||
16733469 | 92293 | 0 | None | -6309 | 4 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 576 | 10 | 2 | 6 | 5.8 | O=C(O)CSc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 | 10.1021/jm070139l | |||
CHEMBL227333 | 92293 | 0 | None | -6309 | 4 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 576 | 10 | 2 | 6 | 5.8 | O=C(O)CSc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 | 10.1021/jm070139l | |||
44296914 | 108026 | 0 | None | -1318 | 2 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 765 | 12 | 5 | 5 | 7.0 | O=C(CC1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC12CC3CC(CC(C3)C1)C2)N[C@@H](Cc1ccccc1)C(=O)Nc1cc(C(=O)O)cc(C(=O)O)c1 | 10.1021/jm9508907 | |||
CHEMBL296167 | 108026 | 0 | None | -1318 | 2 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 765 | 12 | 5 | 5 | 7.0 | O=C(CC1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC12CC3CC(CC(C3)C1)C2)N[C@@H](Cc1ccccc1)C(=O)Nc1cc(C(=O)O)cc(C(=O)O)c1 | 10.1021/jm9508907 | |||
CHEMBL3351052 | 218315 | 0 | None | -14 | 2 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | None | None | None | CN(C(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1cccc2ccccc12)C1CCCCC1)[C@@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C | 10.1021/jm00053a022 | |||||
46235271 | 80423 | 2 | None | 2 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 649 | 7 | 1 | 6 | 6.7 | Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1021/acs.jmedchem.5b01110 | |||
CHEMBL2017835 | 80423 | 2 | None | 2 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 649 | 7 | 1 | 6 | 6.7 | Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1021/acs.jmedchem.5b01110 | |||
44357058 | 171637 | 0 | None | -173 | 2 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 785 | 11 | 5 | 5 | 7.3 | O=C(O)c1cc(NC(=O)[C@@H](Cc2ccccc2Cl)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm00021a019 | |||
CHEMBL421921 | 171637 | 0 | None | -173 | 2 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 785 | 11 | 5 | 5 | 7.3 | O=C(O)c1cc(NC(=O)[C@@H](Cc2ccccc2Cl)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm00021a019 | |||
10794888 | 172031 | 0 | None | -15 | 2 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 707 | 10 | 4 | 4 | 6.9 | O=C(O)c1ccc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc1 | 10.1021/jm00021a019 | |||
CHEMBL422981 | 172031 | 0 | None | -15 | 2 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 707 | 10 | 4 | 4 | 6.9 | O=C(O)c1ccc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc1 | 10.1021/jm00021a019 | |||
16732444 | 150084 | 0 | None | -2570 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 572 | 8 | 2 | 7 | 4.9 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2ccc3cnn(CC(=O)O)c3c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
CHEMBL389713 | 150084 | 0 | None | -2570 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 572 | 8 | 2 | 7 | 4.9 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2ccc3cnn(CC(=O)O)c3c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
44346225 | 168688 | 0 | None | -12022 | 2 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 564 | 6 | 3 | 4 | 5.6 | O=C(Nc1cccc(CO)c1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O | 10.1021/jm990967h | |||
CHEMBL415240 | 168688 | 0 | None | -12022 | 2 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 564 | 6 | 3 | 4 | 5.6 | O=C(Nc1cccc(CO)c1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O | 10.1021/jm990967h | |||
9985629 | 174838 | 0 | None | -41 | 2 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 577 | 8 | 3 | 3 | 6.1 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccc(Br)cc1 | 10.1021/jm00072a005 | |||
CHEMBL432389 | 174838 | 0 | None | -41 | 2 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 577 | 8 | 3 | 3 | 6.1 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccc(Br)cc1 | 10.1021/jm00072a005 | |||
10768308 | 21667 | 0 | None | -19 | 2 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 520 | 4 | 2 | 3 | 5.7 | O=C(Nc1ccccc1)NC1C(=O)N(c2ccccc2)c2ccccc2N(C2[C@H]3C[C@@H]4C[C@@H](C[C@H]2C4)C3)C1=O | 10.1021/jm990967h | |||
CHEMBL120793 | 21667 | 0 | None | -19 | 2 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 520 | 4 | 2 | 3 | 5.7 | O=C(Nc1ccccc1)NC1C(=O)N(c2ccccc2)c2ccccc2N(C2[C@H]3C[C@@H]4C[C@@H](C[C@H]2C4)C3)C1=O | 10.1021/jm990967h | |||
10506830 | 120744 | 0 | None | -6 | 2 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 548 | 6 | 2 | 3 | 6.5 | O=C(Nc1ccccc1)NC1C(=O)N(CCC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O | 10.1021/jm990967h | |||
CHEMBL332601 | 120744 | 0 | None | -6 | 2 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 548 | 6 | 2 | 3 | 6.5 | O=C(Nc1ccccc1)NC1C(=O)N(CCC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O | 10.1021/jm990967h | |||
11664728 | 141199 | 0 | None | -10 | 2 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 482 | 7 | 3 | 2 | 7.1 | Cc1ccccc1-c1cc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 | 10.1021/jm0490686 | |||
CHEMBL371750 | 141199 | 0 | None | -10 | 2 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 482 | 7 | 3 | 2 | 7.1 | Cc1ccccc1-c1cc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 | 10.1021/jm0490686 | |||
10554602 | 22065 | 0 | None | -29 | 2 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 546 | 7 | 2 | 4 | 6.3 | CSc1cccc(NC(=O)NC2C(=O)N(CCC3CCCC3)c3ccccc3N(c3ccccc3F)C2=O)c1 | 10.1021/jm990967h | |||
CHEMBL121331 | 22065 | 0 | None | -29 | 2 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 546 | 7 | 2 | 4 | 6.3 | CSc1cccc(NC(=O)NC2C(=O)N(CCC3CCCC3)c3ccccc3N(c3ccccc3F)C2=O)c1 | 10.1021/jm990967h | |||
10505959 | 120268 | 0 | None | -74 | 2 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 513 | 6 | 2 | 4 | 5.4 | CN(C)c1cccc(NC(=O)NC2C(=O)N(CCC(C)(C)C)c3ccccc3N(c3ccccc3)C2=O)c1 | 10.1021/jm990967h | |||
CHEMBL331975 | 120268 | 0 | None | -74 | 2 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 513 | 6 | 2 | 4 | 5.4 | CN(C)c1cccc(NC(=O)NC2C(=O)N(CCC(C)(C)C)c3ccccc3N(c3ccccc3)C2=O)c1 | 10.1021/jm990967h | |||
44345980 | 120911 | 0 | None | -79 | 2 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 538 | 6 | 2 | 7 | 6.2 | CC(C)(C)CCN1C(=O)C(NC(=O)Nc2cccc(C3N=NN=N3)c2)C(=O)N(c2ccccc2)c2ccccc21 | 10.1021/jm990967h | |||
CHEMBL332902 | 120911 | 0 | None | -79 | 2 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 538 | 6 | 2 | 7 | 6.2 | CC(C)(C)CCN1C(=O)C(NC(=O)Nc2cccc(C3N=NN=N3)c2)C(=O)N(c2ccccc2)c2ccccc21 | 10.1021/jm990967h | |||
44387568 | 68981 | 0 | None | -144 | 3 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 660 | 11 | 7 | 6 | 2.0 | C[C@@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O | 10.1021/jm0000416 | |||
CHEMBL177799 | 68981 | 0 | None | -144 | 3 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 660 | 11 | 7 | 6 | 2.0 | C[C@@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O | 10.1021/jm0000416 | |||
10327028 | 96230 | 0 | None | -144 | 3 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 660 | 11 | 7 | 6 | 2.0 | C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O | 10.1021/jm9603072 | |||
CHEMBL2371222 | 96230 | 0 | None | -144 | 3 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 660 | 11 | 7 | 6 | 2.0 | C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O | 10.1021/jm9603072 | |||
19700615 | 70928 | 0 | None | - | 1 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 589 | 7 | 2 | 5 | 4.2 | O=C(Nc1ccccc1)NC1C(=O)N(CCN2CCOCC2)c2cc(F)ccc2N(CC23CC4CC(CC(C4)C2)C3)C1=O | 10.1016/j.bmc.2011.05.057 | |||
CHEMBL1808417 | 70928 | 0 | None | - | 1 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 589 | 7 | 2 | 5 | 4.2 | O=C(Nc1ccccc1)NC1C(=O)N(CCN2CCOCC2)c2cc(F)ccc2N(CC23CC4CC(CC(C4)C2)C3)C1=O | 10.1016/j.bmc.2011.05.057 | |||
10652142 | 108347 | 0 | None | -1819 | 2 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 679 | 11 | 5 | 6 | 6.2 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3ccsc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm9508907 | |||
CHEMBL298521 | 108347 | 0 | None | -1819 | 2 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 679 | 11 | 5 | 6 | 6.2 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3ccsc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm9508907 | |||
138106885 | 173690 | 75 | None | -1 | 4 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 853 | 10 | 4 | 14 | 3.7 | CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C | nan | |||
36314 | 173690 | 75 | None | -1 | 4 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 853 | 10 | 4 | 14 | 3.7 | CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C | nan | |||
CHEMBL428647 | 173690 | 75 | None | -1 | 4 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 853 | 10 | 4 | 14 | 3.7 | CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C | nan | |||
44331524 | 170445 | 0 | None | -13 | 2 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 530 | 8 | 2 | 3 | 6.5 | CC(CC1CCCC1)N1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(C(C)CC2CCCC2)c2ccccc21 | 10.1016/S0960-894X(96)00544-6 | |||
CHEMBL420459 | 170445 | 0 | None | -13 | 2 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 530 | 8 | 2 | 3 | 6.5 | CC(CC1CCCC1)N1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(C(C)CC2CCCC2)c2ccccc21 | 10.1016/S0960-894X(96)00544-6 | |||
10101023 | 96232 | 0 | None | -57 | 2 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 675 | 11 | 8 | 7 | -0.1 | C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CC(=O)NCCCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O | 10.1021/jm9603072 | |||
CHEMBL2371224 | 96232 | 0 | None | -57 | 2 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 675 | 11 | 8 | 7 | -0.1 | C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CC(=O)NCCCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O | 10.1021/jm9603072 | |||
CHEMBL3350720 | 218267 | 0 | None | -4 | 2 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(N)=O | 10.1021/jm00174a016 | |||||
11541870 | 78226 | 0 | None | -33 | 3 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 433 | 7 | 3 | 3 | 5.4 | O=C(O)c1cccc(NC(=O)c2[nH]c(C3CC3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 | 10.1021/jm0490686 | |||
CHEMBL196141 | 78226 | 0 | None | -33 | 3 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 433 | 7 | 3 | 3 | 5.4 | O=C(O)c1cccc(NC(=O)c2[nH]c(C3CC3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 | 10.1021/jm0490686 | |||
44451622 | 102691 | 0 | None | -371 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 562 | 9 | 2 | 5 | 5.5 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CCC(=O)O)c2)C(=O)N(C2CCCCC2)c2ccccc21 | 10.1016/j.bmc.2007.12.047 | |||
CHEMBL259276 | 102691 | 0 | None | -371 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 562 | 9 | 2 | 5 | 5.5 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CCC(=O)O)c2)C(=O)N(C2CCCCC2)c2ccccc21 | 10.1016/j.bmc.2007.12.047 | |||
44451920 | 102901 | 0 | None | -245 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 519 | 7 | 2 | 5 | 5.5 | CNc1cccc(NC(=O)CN2C(=O)N(CC(=O)C(C)(C)C)c3ccccc3N(C3CCCCC3)C2=O)c1 | 10.1016/j.bmc.2007.12.047 | |||
CHEMBL260394 | 102901 | 0 | None | -245 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 519 | 7 | 2 | 5 | 5.5 | CNc1cccc(NC(=O)CN2C(=O)N(CC(=O)C(C)(C)C)c3ccccc3N(C3CCCCC3)C2=O)c1 | 10.1016/j.bmc.2007.12.047 | |||
10325110 | 118764 | 0 | None | -29 | 2 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 544 | 9 | 3 | 5 | 5.3 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccc([N+](=O)[O-])cc1 | 10.1021/jm00072a005 | |||
CHEMBL328852 | 118764 | 0 | None | -29 | 2 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 544 | 9 | 3 | 5 | 5.3 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccc([N+](=O)[O-])cc1 | 10.1021/jm00072a005 | |||
10006936 | 214504 | 0 | None | -5 | 2 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 521 | 6 | 3 | 3 | 6.8 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)Nc1ccc2ccccc2c1 | 10.1021/jm00072a005 | |||
CHEMBL95689 | 214504 | 0 | None | -5 | 2 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 521 | 6 | 3 | 3 | 6.8 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)Nc1ccc2ccccc2c1 | 10.1021/jm00072a005 | |||
9985004 | 214397 | 0 | None | -26 | 2 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 549 | 8 | 3 | 3 | 6.5 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1cccc2ccccc12 | 10.1021/jm00072a005 | |||
CHEMBL95115 | 214397 | 0 | None | -26 | 2 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 549 | 8 | 3 | 3 | 6.5 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1cccc2ccccc12 | 10.1021/jm00072a005 | |||
44331506 | 114062 | 0 | None | -22 | 2 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 574 | 5 | 2 | 3 | 6.8 | O=C(Nc1cccc(Cl)c1)NC1C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc2N(C2CCCCC2)C1=O | 10.1016/S0960-894X(96)00544-6 | |||
CHEMBL317108 | 114062 | 0 | None | -22 | 2 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 574 | 5 | 2 | 3 | 6.8 | O=C(Nc1cccc(Cl)c1)NC1C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc2N(C2CCCCC2)C1=O | 10.1016/S0960-894X(96)00544-6 | |||
44346825 | 121551 | 0 | None | -77 | 2 | Guinea pig | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 623 | 8 | 3 | 4 | 4.7 | C[C@@H](NC(=O)C[C@@H]1CCCN1C(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC1C2CC3CC(C2)CC1C3)C(=O)O | 10.1021/jm00048a001 | |||
CHEMBL333920 | 121551 | 0 | None | -77 | 2 | Guinea pig | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 623 | 8 | 3 | 4 | 4.7 | C[C@@H](NC(=O)C[C@@H]1CCCN1C(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC1C2CC3CC(C2)CC1C3)C(=O)O | 10.1021/jm00048a001 | |||
52949124 | 7663 | 4 | None | -2 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
9055 | 7663 | 4 | None | -2 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
CHEMBL1269258 | 7663 | 4 | None | -2 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
DB12694 | 7663 | 4 | None | -2 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
CHEMBL3351050 | 218313 | 0 | None | -33 | 2 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | None | None | None | CC(C)(C)OC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1cccc2ccccc12 | 10.1021/jm00053a022 | |||||
CHEMBL171594 | 215627 | 0 | None | -33 | 2 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | None | None | None | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O | 10.1016/S0960-894X(00)80678-2 | |||||
73347063 | 96229 | 0 | None | -162 | 3 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 674 | 11 | 7 | 6 | 2.4 | C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCCCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O | 10.1021/jm9603072 | |||
CHEMBL2371221 | 96229 | 0 | None | -162 | 3 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 674 | 11 | 7 | 6 | 2.4 | C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCCCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O | 10.1021/jm9603072 | |||
22171089 | 100758 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 462 | 8 | 1 | 5 | 5.6 | COc1ccc(-n2nc(CC(C(=O)O)c3cccc(OC)c3)cc2-c2ccc(Cl)cc2)cc1 | 10.1016/j.bmcl.2007.09.093 | |||
CHEMBL248552 | 100758 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 462 | 8 | 1 | 5 | 5.6 | COc1ccc(-n2nc(CC(C(=O)O)c3cccc(OC)c3)cc2-c2ccc(Cl)cc2)cc1 | 10.1016/j.bmcl.2007.09.093 | |||
15002730 | 100799 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 462 | 8 | 1 | 5 | 5.6 | COc1ccc(C(Cc2cc(-c3ccc(Cl)cc3)n(-c3ccc(OC)cc3)n2)C(=O)O)cc1 | 10.1016/j.bmcl.2007.09.093 | |||
CHEMBL248752 | 100799 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 462 | 8 | 1 | 5 | 5.6 | COc1ccc(C(Cc2cc(-c3ccc(Cl)cc3)n(-c3ccc(OC)cc3)n2)C(=O)O)cc1 | 10.1016/j.bmcl.2007.09.093 | |||
22171039 | 100800 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 446 | 7 | 1 | 4 | 5.9 | COc1ccc(-n2nc(CC(C(=O)O)c3ccc(C)cc3)cc2-c2ccc(Cl)cc2)cc1 | 10.1016/j.bmcl.2007.09.093 | |||
CHEMBL248754 | 100800 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 446 | 7 | 1 | 4 | 5.9 | COc1ccc(-n2nc(CC(C(=O)O)c3ccc(C)cc3)cc2-c2ccc(Cl)cc2)cc1 | 10.1016/j.bmcl.2007.09.093 | |||
44444767 | 100833 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 432 | 7 | 1 | 4 | 5.6 | COc1ccc(-n2nc(CC(C(=O)O)c3ccccc3)cc2-c2ccc(Cl)cc2)cc1 | 10.1016/j.bmcl.2007.09.093 | |||
CHEMBL248948 | 100833 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 432 | 7 | 1 | 4 | 5.6 | COc1ccc(-n2nc(CC(C(=O)O)c3ccccc3)cc2-c2ccc(Cl)cc2)cc1 | 10.1016/j.bmcl.2007.09.093 | |||
10343558 | 100834 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 446 | 7 | 1 | 4 | 5.9 | COc1ccc(-n2nc(CC(C(=O)O)c3cccc(Cl)c3)cc2-c2ccc(C)cc2)cc1 | 10.1016/j.bmcl.2007.09.093 | |||
CHEMBL248949 | 100834 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 446 | 7 | 1 | 4 | 5.9 | COc1ccc(-n2nc(CC(C(=O)O)c3cccc(Cl)c3)cc2-c2ccc(C)cc2)cc1 | 10.1016/j.bmcl.2007.09.093 | |||
15002734 | 100835 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 442 | 8 | 1 | 5 | 5.3 | COc1ccc(-n2nc(CC(C(=O)O)c3ccccc3OC)cc2-c2ccc(C)cc2)cc1 | 10.1016/j.bmcl.2007.09.093 | |||
CHEMBL248950 | 100835 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 442 | 8 | 1 | 5 | 5.3 | COc1ccc(-n2nc(CC(C(=O)O)c3ccccc3OC)cc2-c2ccc(C)cc2)cc1 | 10.1016/j.bmcl.2007.09.093 | |||
10388627 | 100877 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 442 | 8 | 1 | 5 | 5.3 | COc1ccc(-n2nc(CC(C(=O)O)c3cccc(OC)c3)cc2-c2ccc(C)cc2)cc1 | 10.1016/j.bmcl.2007.09.093 | |||
CHEMBL249151 | 100877 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 442 | 8 | 1 | 5 | 5.3 | COc1ccc(-n2nc(CC(C(=O)O)c3cccc(OC)c3)cc2-c2ccc(C)cc2)cc1 | 10.1016/j.bmcl.2007.09.093 | |||
10366068 | 100878 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 442 | 8 | 1 | 5 | 5.3 | COc1ccc(C(Cc2cc(-c3ccc(C)cc3)n(-c3ccc(OC)cc3)n2)C(=O)O)cc1 | 10.1016/j.bmcl.2007.09.093 | |||
CHEMBL249153 | 100878 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 442 | 8 | 1 | 5 | 5.3 | COc1ccc(C(Cc2cc(-c3ccc(C)cc3)n(-c3ccc(OC)cc3)n2)C(=O)O)cc1 | 10.1016/j.bmcl.2007.09.093 | |||
22171037 | 100918 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 426 | 7 | 1 | 4 | 5.6 | COc1ccc(-n2nc(CC(C(=O)O)c3cccc(C)c3)cc2-c2ccc(C)cc2)cc1 | 10.1016/j.bmcl.2007.09.093 | |||
CHEMBL249361 | 100918 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 426 | 7 | 1 | 4 | 5.6 | COc1ccc(-n2nc(CC(C(=O)O)c3cccc(C)c3)cc2-c2ccc(C)cc2)cc1 | 10.1016/j.bmcl.2007.09.093 | |||
10320262 | 100945 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 426 | 7 | 1 | 4 | 5.6 | COc1ccc(-n2nc(CC(C(=O)O)c3ccc(C)cc3)cc2-c2ccc(C)cc2)cc1 | 10.1016/j.bmcl.2007.09.093 | |||
CHEMBL249560 | 100945 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 426 | 7 | 1 | 4 | 5.6 | COc1ccc(-n2nc(CC(C(=O)O)c3ccc(C)cc3)cc2-c2ccc(C)cc2)cc1 | 10.1016/j.bmcl.2007.09.093 | |||
44444777 | 100974 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 412 | 7 | 1 | 4 | 5.3 | COc1ccc(-n2nc(CC(C(=O)O)c3ccccc3)cc2-c2ccc(C)cc2)cc1 | 10.1016/j.bmcl.2007.09.093 | |||
CHEMBL249763 | 100974 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 412 | 7 | 1 | 4 | 5.3 | COc1ccc(-n2nc(CC(C(=O)O)c3ccccc3)cc2-c2ccc(C)cc2)cc1 | 10.1016/j.bmcl.2007.09.093 | |||
11754311 | 101098 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 466 | 7 | 1 | 4 | 6.3 | COc1ccc(-n2nc(CC(C(=O)O)c3ccc(Cl)cc3)cc2-c2ccc(Cl)cc2)cc1 | 10.1016/j.bmcl.2007.09.093 | |||
CHEMBL250576 | 101098 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 466 | 7 | 1 | 4 | 6.3 | COc1ccc(-n2nc(CC(C(=O)O)c3ccc(Cl)cc3)cc2-c2ccc(Cl)cc2)cc1 | 10.1016/j.bmcl.2007.09.093 | |||
22171092 | 161278 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 446 | 7 | 1 | 4 | 5.9 | COc1ccc(-n2nc(CC(C(=O)O)c3cccc(C)c3)cc2-c2ccc(Cl)cc2)cc1 | 10.1016/j.bmcl.2007.09.093 | |||
CHEMBL399055 | 161278 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 446 | 7 | 1 | 4 | 5.9 | COc1ccc(-n2nc(CC(C(=O)O)c3cccc(C)c3)cc2-c2ccc(Cl)cc2)cc1 | 10.1016/j.bmcl.2007.09.093 | |||
10433726 | 161279 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 446 | 7 | 1 | 4 | 5.9 | COc1ccc(-n2nc(CC(C(=O)O)c3ccc(Cl)cc3)cc2-c2ccc(C)cc2)cc1 | 10.1016/j.bmcl.2007.09.093 | |||
CHEMBL399056 | 161279 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 446 | 7 | 1 | 4 | 5.9 | COc1ccc(-n2nc(CC(C(=O)O)c3ccc(Cl)cc3)cc2-c2ccc(C)cc2)cc1 | 10.1016/j.bmcl.2007.09.093 | |||
22171012 | 161513 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 466 | 7 | 1 | 4 | 6.3 | COc1ccc(-n2nc(CC(C(=O)O)c3cccc(Cl)c3)cc2-c2ccc(Cl)cc2)cc1 | 10.1016/j.bmcl.2007.09.093 | |||
CHEMBL399915 | 161513 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 466 | 7 | 1 | 4 | 6.3 | COc1ccc(-n2nc(CC(C(=O)O)c3cccc(Cl)c3)cc2-c2ccc(Cl)cc2)cc1 | 10.1016/j.bmcl.2007.09.093 | |||
44444763 | 161648 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 462 | 8 | 1 | 5 | 5.6 | COc1ccc(-n2nc(CC(C(=O)O)c3ccccc3OC)cc2-c2ccc(Cl)cc2)cc1 | 10.1016/j.bmcl.2007.09.093 | |||
CHEMBL400670 | 161648 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 462 | 8 | 1 | 5 | 5.6 | COc1ccc(-n2nc(CC(C(=O)O)c3ccccc3OC)cc2-c2ccc(Cl)cc2)cc1 | 10.1016/j.bmcl.2007.09.093 | |||
45486974 | 204469 | 0 | None | 50 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 580 | 7 | 3 | 7 | 4.8 | C[C@@H](NC(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)[C@@H](O)c1cccc(Br)c1 | 10.1016/j.bmcl.2009.09.064 | |||
CHEMBL571206 | 204469 | 0 | None | 50 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 580 | 7 | 3 | 7 | 4.8 | C[C@@H](NC(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)[C@@H](O)c1cccc(Br)c1 | 10.1016/j.bmcl.2009.09.064 | |||
44271963 | 103500 | 0 | None | -4466 | 2 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 1274 | 26 | 13 | 15 | 2.1 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCCNC(=O)[C@H](NC(=O)OC(C)(C)C)CCC(=O)N[C@H](Cc2ccc(OS(=O)(=O)O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/jm00126a007 | |||
CHEMBL264273 | 103500 | 0 | None | -4466 | 2 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 1274 | 26 | 13 | 15 | 2.1 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCCNC(=O)[C@H](NC(=O)OC(C)(C)C)CCC(=O)N[C@H](Cc2ccc(OS(=O)(=O)O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/jm00126a007 | |||
11555184 | 172811 | 0 | None | -281 | 3 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 503 | 7 | 3 | 3 | 7.0 | Cc1ccc(NC(=O)c2[nH]c(C3(C)CCCCC3)nc2CCC23CC4CC(CC(C4)C2)C3)cc1C(=O)O | 10.1021/jm0490686 | |||
CHEMBL425574 | 172811 | 0 | None | -281 | 3 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 503 | 7 | 3 | 3 | 7.0 | Cc1ccc(NC(=O)c2[nH]c(C3(C)CCCCC3)nc2CCC23CC4CC(CC(C4)C2)C3)cc1C(=O)O | 10.1021/jm0490686 | |||
45255234 | 205815 | 0 | None | -15 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 584 | 8 | 3 | 7 | 4.9 | O=C(N[C@@H](Cc1ccc(Cl)c(Cl)c1)C(=O)O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 | 10.1016/j.bmcl.2009.09.064 | |||
CHEMBL585914 | 205815 | 0 | None | -15 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 584 | 8 | 3 | 7 | 4.9 | O=C(N[C@@H](Cc1ccc(Cl)c(Cl)c1)C(=O)O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 | 10.1016/j.bmcl.2009.09.064 | |||
45486935 | 203538 | 0 | None | -25 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 612 | 8 | 3 | 7 | 4.5 | O=C(N[C@@H](Cc1ccc(F)c(Br)c1)C(=O)O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 | 10.1016/j.bmcl.2009.09.065 | |||
CHEMBL565298 | 203538 | 0 | None | -25 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 612 | 8 | 3 | 7 | 4.5 | O=C(N[C@@H](Cc1ccc(F)c(Br)c1)C(=O)O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 | 10.1016/j.bmcl.2009.09.065 | |||
45486976 | 205751 | 0 | None | -39 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 656 | 8 | 3 | 7 | 4.6 | O=C(N[C@@H](Cc1ccc(F)c(Br)c1)C(=O)O)c1ccc(Br)cc1NS(=O)(=O)c1cccc2nsnc12 | 10.1016/j.bmcl.2009.09.065 | |||
CHEMBL585157 | 205751 | 0 | None | -39 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 656 | 8 | 3 | 7 | 4.6 | O=C(N[C@@H](Cc1ccc(F)c(Br)c1)C(=O)O)c1ccc(Br)cc1NS(=O)(=O)c1cccc2nsnc12 | 10.1016/j.bmcl.2009.09.065 | |||
10792724 | 21182 | 0 | None | -162 | 2 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 548 | 5 | 2 | 3 | 6.4 | Cc1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 | 10.1021/jm990967h | |||
CHEMBL120031 | 21182 | 0 | None | -162 | 2 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 548 | 5 | 2 | 3 | 6.4 | Cc1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 | 10.1021/jm990967h | |||
10793611 | 22271 | 0 | None | -4 | 2 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 594 | 7 | 2 | 4 | 7.2 | CSc1cccc(NC(=O)NC2C(=O)N(CCC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 | 10.1021/jm990967h | |||
CHEMBL121624 | 22271 | 0 | None | -4 | 2 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 594 | 7 | 2 | 4 | 7.2 | CSc1cccc(NC(=O)NC2C(=O)N(CCC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 | 10.1021/jm990967h | |||
19043400 | 105518 | 0 | None | -162 | 2 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 480 | 4 | 2 | 3 | 5.1 | O=C(Nc1ccccc1)NC1C(=O)N(c2ccccc2)c2ccccc2N(C2CC3CCC2C3)C1=O | 10.1021/jm990967h | |||
CHEMBL278018 | 105518 | 0 | None | -162 | 2 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 480 | 4 | 2 | 3 | 5.1 | O=C(Nc1ccccc1)NC1C(=O)N(c2ccccc2)c2ccccc2N(C2CC3CCC2C3)C1=O | 10.1021/jm990967h | |||
9869202 | 78851 | 0 | None | -3 | 2 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 467 | 6 | 3 | 3 | 6.7 | O=C(O)c1cccc(NC(=O)c2[nH]c(-c3ccc4ccccc4c3)nc2CC2CCCCCC2)c1 | 10.1021/jm0490686 | |||
CHEMBL197716 | 78851 | 0 | None | -3 | 2 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 467 | 6 | 3 | 3 | 6.7 | O=C(O)c1cccc(NC(=O)c2[nH]c(-c3ccc4ccccc4c3)nc2CC2CCCCCC2)c1 | 10.1021/jm0490686 | |||
CHEMBL2067960 | 78851 | 0 | None | -3 | 2 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 467 | 6 | 3 | 3 | 6.7 | O=C(O)c1cccc(NC(=O)c2[nH]c(-c3ccc4ccccc4c3)nc2CC2CCCCCC2)c1 | 10.1021/jm0490686 | |||
44444930 | 161701 | 0 | None | - | 1 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 688 | 11 | 6 | 6 | 5.7 | Nc1cccc2cc(C(=O)N[C@@H](Cc3ccccc3)C(=O)Nc3cc(C(=O)O)cc(C(=O)O)c3)c(C(=O)NCC34CC5CC(CC(C5)C3)C4)cc12 | 10.1021/jm070880t | |||
CHEMBL400974 | 161701 | 0 | None | - | 1 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 688 | 11 | 6 | 6 | 5.7 | Nc1cccc2cc(C(=O)N[C@@H](Cc3ccccc3)C(=O)Nc3cc(C(=O)O)cc(C(=O)O)c3)c(C(=O)NCC34CC5CC(CC(C5)C3)C4)cc12 | 10.1021/jm070880t | |||
44444931 | 161724 | 0 | None | - | 1 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 688 | 11 | 6 | 6 | 5.7 | Nc1cccc2cc(C(=O)NCC34CC5CC(CC(C5)C3)C4)c(C(=O)N[C@@H](Cc3ccccc3)C(=O)Nc3cc(C(=O)O)cc(C(=O)O)c3)cc12 | 10.1021/jm070880t | |||
CHEMBL401097 | 161724 | 0 | None | - | 1 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 688 | 11 | 6 | 6 | 5.7 | Nc1cccc2cc(C(=O)NCC34CC5CC(CC(C5)C3)C4)c(C(=O)N[C@@H](Cc3ccccc3)C(=O)Nc3cc(C(=O)O)cc(C(=O)O)c3)cc12 | 10.1021/jm070880t | |||
16090789 | 90025 | 0 | None | 3 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 521 | 6 | 2 | 7 | 4.4 | O=C(Nc1ccc(C(=O)N2CCCCC2)c(NS(=O)(=O)c2cccc3nsnc23)c1)c1ccccc1 | 10.1021/jm060590x | |||
CHEMBL218729 | 90025 | 0 | None | 3 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 521 | 6 | 2 | 7 | 4.4 | O=C(Nc1ccc(C(=O)N2CCCCC2)c(NS(=O)(=O)c2cccc3nsnc23)c1)c1ccccc1 | 10.1021/jm060590x | |||
16733466 | 92292 | 0 | None | -7413 | 4 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 558 | 10 | 2 | 5 | 5.6 | O=C(O)CCc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 | 10.1021/jm070139l | |||
CHEMBL227330 | 92292 | 0 | None | -7413 | 4 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 558 | 10 | 2 | 5 | 5.6 | O=C(O)CCc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 | 10.1021/jm070139l | |||
16732165 | 175727 | 0 | None | -3235 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 571 | 8 | 2 | 6 | 5.5 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2ccc3c(ccn3CC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
CHEMBL438843 | 175727 | 0 | None | -3235 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 571 | 8 | 2 | 6 | 5.5 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2ccc3c(ccn3CC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
9936141 | 19034 | 0 | None | -12 | 2 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 510 | 7 | 4 | 3 | 7.0 | O=C(O)c1cc(NC(=O)c2cc(-c3ccc4ccccc4c3)[nH]c2CC2CCCCCC2)cc(C(=O)O)c1 | 10.1021/jm049069y | |||
CHEMBL1184700 | 19034 | 0 | None | -12 | 2 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 510 | 7 | 4 | 3 | 7.0 | O=C(O)c1cc(NC(=O)c2cc(-c3ccc4ccccc4c3)[nH]c2CC2CCCCCC2)cc(C(=O)O)c1 | 10.1021/jm049069y | |||
CHEMBL2067956 | 19034 | 0 | None | -12 | 2 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 510 | 7 | 4 | 3 | 7.0 | O=C(O)c1cc(NC(=O)c2cc(-c3ccc4ccccc4c3)[nH]c2CC2CCCCCC2)cc(C(=O)O)c1 | 10.1021/jm049069y | |||
9869202 | 78851 | 0 | None | -3 | 2 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 467 | 6 | 3 | 3 | 6.7 | O=C(O)c1cccc(NC(=O)c2[nH]c(-c3ccc4ccccc4c3)nc2CC2CCCCCC2)c1 | 10.1021/jm049069y | |||
CHEMBL197716 | 78851 | 0 | None | -3 | 2 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 467 | 6 | 3 | 3 | 6.7 | O=C(O)c1cccc(NC(=O)c2[nH]c(-c3ccc4ccccc4c3)nc2CC2CCCCCC2)c1 | 10.1021/jm049069y | |||
CHEMBL2067960 | 78851 | 0 | None | -3 | 2 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 467 | 6 | 3 | 3 | 6.7 | O=C(O)c1cccc(NC(=O)c2[nH]c(-c3ccc4ccccc4c3)nc2CC2CCCCCC2)c1 | 10.1021/jm049069y | |||
44444932 | 161629 | 0 | None | - | 1 | Guinea pig | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 623 | 8 | 3 | 4 | 4.8 | C[C@@H](NC(=O)C[C@@H]1CCCN1C(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC12CC3CC(CC(C3)C1)C2)C(=O)O | 10.1021/jm070880t | |||
CHEMBL400548 | 161629 | 0 | None | - | 1 | Guinea pig | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 623 | 8 | 3 | 4 | 4.8 | C[C@@H](NC(=O)C[C@@H]1CCCN1C(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC12CC3CC(CC(C3)C1)C2)C(=O)O | 10.1021/jm070880t | |||
44357208 | 125761 | 0 | None | -4 | 2 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 737 | 10 | 5 | 5 | 6.7 | O=C(O)c1cc(NC(=O)[C@H](NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)c2ccccc2)cc(C(=O)O)c1 | 10.1021/jm00021a019 | |||
CHEMBL342465 | 125761 | 0 | None | -4 | 2 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 737 | 10 | 5 | 5 | 6.7 | O=C(O)c1cc(NC(=O)[C@H](NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)c2ccccc2)cc(C(=O)O)c1 | 10.1021/jm00021a019 | |||
56673524 | 70929 | 0 | None | - | 1 | Rat | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 589 | 7 | 2 | 5 | 4.2 | O=C(Nc1ccc(F)cc1)NC1C(=O)N(CCN2CCOCC2)c2ccccc2N(CC23CC4CC(CC(C4)C2)C3)C1=O | 10.1016/j.bmc.2011.05.057 | |||
CHEMBL1808418 | 70929 | 0 | None | - | 1 | Rat | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 589 | 7 | 2 | 5 | 4.2 | O=C(Nc1ccc(F)cc1)NC1C(=O)N(CCN2CCOCC2)c2ccccc2N(CC23CC4CC(CC(C4)C2)C3)C1=O | 10.1016/j.bmc.2011.05.057 | |||
10842269 | 108351 | 0 | None | -575 | 2 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 681 | 11 | 6 | 6 | 5.0 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2F)NC(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm9508907 | |||
CHEMBL298551 | 108351 | 0 | None | -575 | 2 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 681 | 11 | 6 | 6 | 5.0 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2F)NC(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm9508907 | |||
10698746 | 123563 | 0 | None | -3 | 2 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 595 | 7 | 3 | 4 | 4.0 | O=C(O)CNC(=O)[C@H]1CCCN1C(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC12C[C@H]3C[C@@H](C1)C[C@@H](C2)C3 | 10.1021/jm00021a019 | |||
CHEMBL337743 | 123563 | 0 | None | -3 | 2 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 595 | 7 | 3 | 4 | 4.0 | O=C(O)CNC(=O)[C@H]1CCCN1C(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC12C[C@H]3C[C@@H](C1)C[C@@H](C2)C3 | 10.1021/jm00021a019 | |||
19700615 | 70928 | 0 | None | - | 1 | Rat | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 589 | 7 | 2 | 5 | 4.2 | O=C(Nc1ccccc1)NC1C(=O)N(CCN2CCOCC2)c2cc(F)ccc2N(CC23CC4CC(CC(C4)C2)C3)C1=O | 10.1016/j.bmc.2011.05.057 | |||
CHEMBL1808417 | 70928 | 0 | None | - | 1 | Rat | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 589 | 7 | 2 | 5 | 4.2 | O=C(Nc1ccccc1)NC1C(=O)N(CCN2CCOCC2)c2cc(F)ccc2N(CC23CC4CC(CC(C4)C2)C3)C1=O | 10.1016/j.bmc.2011.05.057 | |||
11799257 | 120244 | 0 | None | -32 | 2 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 490 | 6 | 2 | 3 | 5.1 | O=C(Nc1ccccc1)NC1C(=O)N(CCc2ccccc2)c2ccccc2N(c2ccccc2)C1=O | 10.1021/jm990967h | |||
CHEMBL331929 | 120244 | 0 | None | -32 | 2 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 490 | 6 | 2 | 3 | 5.1 | O=C(Nc1ccccc1)NC1C(=O)N(CCc2ccccc2)c2ccccc2N(c2ccccc2)C1=O | 10.1021/jm990967h | |||
10795162 | 125816 | 0 | None | -630 | 2 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 751 | 11 | 5 | 5 | 6.6 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm00021a019 | |||
CHEMBL2067970 | 125816 | 0 | None | -630 | 2 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 751 | 11 | 5 | 5 | 6.6 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm00021a019 | |||
CHEMBL342616 | 125816 | 0 | None | -630 | 2 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 751 | 11 | 5 | 5 | 6.6 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm00021a019 | |||
19700643 | 70793 | 0 | None | - | 1 | Rat | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 505 | 9 | 2 | 4 | 4.5 | CCN(CC)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(CC2CCCCC2)c2ccccc21 | 10.1016/j.bmc.2011.05.057 | |||
CHEMBL1807152 | 70793 | 0 | None | - | 1 | Rat | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 505 | 9 | 2 | 4 | 4.5 | CCN(CC)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(CC2CCCCC2)c2ccccc21 | 10.1016/j.bmc.2011.05.057 | |||
10439779 | 113463 | 0 | None | -5 | 3 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 710 | 11 | 7 | 8 | 2.2 | C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCSSCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O | 10.1021/jm9603072 | |||
CHEMBL3143501 | 113463 | 0 | None | -5 | 3 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 710 | 11 | 7 | 8 | 2.2 | C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCSSCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O | 10.1021/jm9603072 | |||
52949124 | 7663 | 4 | None | -2 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
9055 | 7663 | 4 | None | -2 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
CHEMBL1269258 | 7663 | 4 | None | -2 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
DB12694 | 7663 | 4 | None | -2 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
56663144 | 70913 | 0 | None | - | 1 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 507 | 8 | 2 | 5 | 3.2 | Cc1cccc(NC(=O)NC2C(=O)N(CCC(C)C)c3ccccc3N(CCN3CCOCC3)C2=O)c1 | 10.1016/j.bmc.2011.05.057 | |||
CHEMBL1808400 | 70913 | 0 | None | - | 1 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 507 | 8 | 2 | 5 | 3.2 | Cc1cccc(NC(=O)NC2C(=O)N(CCC(C)C)c3ccccc3N(CCN3CCOCC3)C2=O)c1 | 10.1016/j.bmc.2011.05.057 | |||
46235271 | 80423 | 2 | None | 2 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 649 | 7 | 1 | 6 | 6.7 | Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1021/acs.jmedchem.5b01110 | |||
CHEMBL2017835 | 80423 | 2 | None | 2 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 649 | 7 | 1 | 6 | 6.7 | Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1021/acs.jmedchem.5b01110 | |||
887 | 10882 | 33 | None | -380 | 4 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 498 | 6 | 3 | 6 | 4.1 | CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 | 10.1021/jm070139l | |||
9870520 | 10882 | 33 | None | -380 | 4 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 498 | 6 | 3 | 6 | 4.1 | CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 | 10.1021/jm070139l | |||
CHEMBL324547 | 10882 | 33 | None | -380 | 4 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 498 | 6 | 3 | 6 | 4.1 | CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 | 10.1021/jm070139l | |||
DB12355 | 10882 | 33 | None | -380 | 4 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 498 | 6 | 3 | 6 | 4.1 | CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 | 10.1021/jm070139l | |||
44451581 | 102600 | 0 | None | -316 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 594 | 9 | 2 | 6 | 6.0 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(SCC(=O)O)c2)C(=O)N(C2CCCCCC2)c2ccccc21 | 10.1016/j.bmc.2007.12.047 | |||
CHEMBL258863 | 102600 | 0 | None | -316 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 594 | 9 | 2 | 6 | 6.0 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(SCC(=O)O)c2)C(=O)N(C2CCCCCC2)c2ccccc21 | 10.1016/j.bmc.2007.12.047 | |||
10652140 | 108621 | 0 | None | -177 | 2 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 679 | 11 | 7 | 7 | 4.6 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm9508907 | |||
CHEMBL300456 | 108621 | 0 | None | -177 | 2 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 679 | 11 | 7 | 7 | 4.6 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm9508907 | |||
44329398 | 214467 | 0 | None | -12 | 2 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 543 | 10 | 3 | 4 | 4.8 | O=C(O)CN(CCc1ccccc1)C(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1021/jm00072a005 | |||
CHEMBL95461 | 214467 | 0 | None | -12 | 2 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 543 | 10 | 3 | 4 | 4.8 | O=C(O)CN(CCc1ccccc1)C(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1021/jm00072a005 | |||
10098459 | 11038 | 0 | None | -208 | 2 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 528 | 7 | 2 | 3 | 5.8 | CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc21 | 10.1016/S0960-894X(96)00544-6 | |||
CHEMBL100548 | 11038 | 0 | None | -208 | 2 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 528 | 7 | 2 | 3 | 5.8 | CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc21 | 10.1016/S0960-894X(96)00544-6 | |||
73354642 | 96233 | 0 | None | -46 | 3 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 646 | 11 | 7 | 6 | 1.6 | C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O | 10.1021/jm9603072 | |||
CHEMBL2371225 | 96233 | 0 | None | -46 | 3 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 646 | 11 | 7 | 6 | 1.6 | C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O | 10.1021/jm9603072 | |||
11568611 | 78754 | 0 | None | -263 | 3 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 449 | 6 | 3 | 3 | 5.8 | CC(C)(C)c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 | 10.1021/jm0490686 | |||
CHEMBL197370 | 78754 | 0 | None | -263 | 3 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 449 | 6 | 3 | 3 | 5.8 | CC(C)(C)c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 | 10.1021/jm0490686 | |||
5311188 | 16577 | 2 | None | -1 | 2 | Rat | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 559 | 7 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm9703247 | |||
CHEMBL113718 | 16577 | 2 | None | -1 | 2 | Rat | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 559 | 7 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm9703247 | |||
44265912 | 213186 | 0 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 354 | 6 | 2 | 1 | 5.1 | O=C(NCCC(c1ccccc1)c1ccccc1)c1cc2ccccc2[nH]1 | 10.1021/jm00084a009 | |||
CHEMBL8779 | 213186 | 0 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 354 | 6 | 2 | 1 | 5.1 | O=C(NCCC(c1ccccc1)c1ccccc1)c1cc2ccccc2[nH]1 | 10.1021/jm00084a009 | |||
44346355 | 164646 | 0 | None | -446 | 3 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 1260 | 26 | 13 | 15 | 1.7 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CCCCNC(=O)C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc2ccc(OS(=O)(=O)O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm0000416 | |||
CHEMBL408389 | 164646 | 0 | None | -446 | 3 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 1260 | 26 | 13 | 15 | 1.7 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CCCCNC(=O)C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc2ccc(OS(=O)(=O)O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm0000416 | |||
CHEMBL2370588 | 216651 | 0 | None | -446 | 2 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCCNC(=O)C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc2ccc(OS(=O)(=O)O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/jm00126a007 | |||||
CHEMBL3350335 | 218253 | 0 | None | -245 | 2 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C | 10.1021/jm00053a022 | |||||
CHEMBL3142843 | 217915 | 0 | None | -6 | 2 | Guinea pig | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | None | None | None | CC(C)(C)OC(=O)NCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(N)=O | 10.1021/jm00174a016 | |||||
11495719 | 77148 | 0 | None | -14 | 3 | Guinea pig | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 431 | 7 | 3 | 3 | 5.8 | Cc1ccccc1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC2CCCCC2)[nH]1 | 10.1021/jm0490686 | |||
CHEMBL194514 | 77148 | 0 | None | -14 | 3 | Guinea pig | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 431 | 7 | 3 | 3 | 5.8 | Cc1ccccc1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC2CCCCC2)[nH]1 | 10.1021/jm0490686 | |||
10817243 | 120294 | 0 | None | -22 | 2 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 591 | 7 | 2 | 4 | 6.6 | CN(C)c1cccc(NC(=O)NC2C(=O)N(CCC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 | 10.1021/jm990967h | |||
CHEMBL332128 | 120294 | 0 | None | -22 | 2 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 591 | 7 | 2 | 4 | 6.6 | CN(C)c1cccc(NC(=O)NC2C(=O)N(CCC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 | 10.1021/jm990967h | |||
16733051 | 143734 | 0 | None | -758 | 2 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 595 | 8 | 2 | 7 | 4.2 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)NS(C)(=O)=O)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
CHEMBL374390 | 143734 | 0 | None | -758 | 2 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 595 | 8 | 2 | 7 | 4.2 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)NS(C)(=O)=O)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
11800981 | 16982 | 0 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 559 | 7 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm9703247 | |||
CHEMBL116001 | 16982 | 0 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 559 | 7 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@@H]12 | 10.1021/jm9703247 | |||
44379428 | 64948 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 557 | 9 | 3 | 6 | 4.9 | C[C@@](N)(Cc1cn(C(=O)OC2C3CC4CC(C3)CC2C4)c2ccccc12)C(=O)N[C@H](CC(=O)O)Cc1ccccc1 | 10.1016/S0960-894X(00)80669-1 | |||
CHEMBL168182 | 64948 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 557 | 9 | 3 | 6 | 4.9 | C[C@@](N)(Cc1cn(C(=O)OC2C3CC4CC(C3)CC2C4)c2ccccc12)C(=O)N[C@H](CC(=O)O)Cc1ccccc1 | 10.1016/S0960-894X(00)80669-1 | |||
CHEMBL1206136 | 215383 | 0 | None | - | 1 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCCC)NC(=O)[C@@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00122a026 | |||||
CHEMBL218455 | 215383 | 0 | None | - | 1 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCCC)NC(=O)[C@@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00122a026 | |||||
10372489 | 11035 | 0 | None | - | 1 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 692 | 20 | 7 | 7 | 1.3 | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCC(=O)O | 10.1021/jm0000416 | |||
CHEMBL100538 | 11035 | 0 | None | - | 1 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 692 | 20 | 7 | 7 | 1.3 | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCC(=O)O | 10.1021/jm0000416 | |||
44359425 | 21516 | 0 | None | - | 1 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 1031 | 30 | 11 | 11 | 1.0 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00122a026 | |||
CHEMBL1206331 | 21516 | 0 | None | - | 1 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 1031 | 30 | 11 | 11 | 1.0 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00122a026 | |||
CHEMBL262687 | 21516 | 0 | None | - | 1 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 1031 | 30 | 11 | 11 | 1.0 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00122a026 | |||
90662935 | 113352 | 0 | None | 10 | 2 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 1057 | 30 | 11 | 11 | 2.6 | CCCC[C@H](NC(=O)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C/c1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm990252e | |||
CHEMBL3142373 | 113352 | 0 | None | 10 | 2 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 1057 | 30 | 11 | 11 | 2.6 | CCCC[C@H](NC(=O)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C/c1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm990252e | |||
53465844 | 76186 | 0 | None | 131 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 441 | 8 | 4 | 3 | 4.2 | O=C(Nc1ccccc1C(=O)N[C@H](CCc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 | 10.1021/jm200438b | |||
CHEMBL1933104 | 76186 | 0 | None | 131 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 441 | 8 | 4 | 3 | 4.2 | O=C(Nc1ccccc1C(=O)N[C@H](CCc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 | 10.1021/jm200438b | |||
10075052 | 196453 | 0 | None | 10 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 510 | 3 | 2 | 3 | 4.3 | CN1C(=O)[C@H](NC(=O)Nc2cccc(I)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm801439x | |||
CHEMBL515268 | 196453 | 0 | None | 10 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 510 | 3 | 2 | 3 | 4.3 | CN1C(=O)[C@H](NC(=O)Nc2cccc(I)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm801439x | |||
CHEMBL515288 | 196453 | 0 | None | 10 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 510 | 3 | 2 | 3 | 4.3 | CN1C(=O)[C@H](NC(=O)Nc2cccc(I)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm801439x | |||
53465844 | 76186 | 0 | None | 131 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 441 | 8 | 4 | 3 | 4.2 | O=C(Nc1ccccc1C(=O)N[C@H](CCc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 | 10.1021/jm200438b | |||
CHEMBL1933104 | 76186 | 0 | None | 131 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 441 | 8 | 4 | 3 | 4.2 | O=C(Nc1ccccc1C(=O)N[C@H](CCc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 | 10.1021/jm200438b | |||
44215880 | 76183 | 0 | None | 3890 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 441 | 8 | 4 | 3 | 4.2 | O=C(Nc1ccccc1C(=O)NC(CCc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 | 10.1021/jm200438b | |||
CHEMBL1933100 | 76183 | 0 | None | 3890 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 441 | 8 | 4 | 3 | 4.2 | O=C(Nc1ccccc1C(=O)NC(CCc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 | 10.1021/jm200438b | |||
887 | 10882 | 33 | None | -380 | 4 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 498 | 6 | 3 | 6 | 4.1 | CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 | 10.1021/jm051219x | |||
9870520 | 10882 | 33 | None | -380 | 4 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 498 | 6 | 3 | 6 | 4.1 | CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 | 10.1021/jm051219x | |||
CHEMBL324547 | 10882 | 33 | None | -380 | 4 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 498 | 6 | 3 | 6 | 4.1 | CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 | 10.1021/jm051219x | |||
DB12355 | 10882 | 33 | None | -380 | 4 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 498 | 6 | 3 | 6 | 4.1 | CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 | 10.1021/jm051219x | |||
10460632 | 215109 | 0 | None | -43 | 2 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 568 | 10 | 2 | 4 | 5.8 | CC(Cc1ccc2ccccc2c1)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccc1)CC(=O)O | 10.1021/jm00072a005 | |||
CHEMBL99252 | 215109 | 0 | None | -43 | 2 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 568 | 10 | 2 | 4 | 5.8 | CC(Cc1ccc2ccccc2c1)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccc1)CC(=O)O | 10.1021/jm00072a005 | |||
9890720 | 175249 | 0 | None | -2 | 2 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 466 | 6 | 3 | 2 | 7.3 | O=C(O)c1cccc(NC(=O)c2cc(-c3ccc4ccccc4c3)[nH]c2CC2CCCCCC2)c1 | 10.1021/jm0490686 | |||
CHEMBL2067971 | 175249 | 0 | None | -2 | 2 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 466 | 6 | 3 | 2 | 7.3 | O=C(O)c1cccc(NC(=O)c2cc(-c3ccc4ccccc4c3)[nH]c2CC2CCCCCC2)c1 | 10.1021/jm0490686 | |||
CHEMBL435127 | 175249 | 0 | None | -2 | 2 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 466 | 6 | 3 | 2 | 7.3 | O=C(O)c1cccc(NC(=O)c2cc(-c3ccc4ccccc4c3)[nH]c2CC2CCCCCC2)c1 | 10.1021/jm0490686 | |||
44356448 | 175018 | 0 | None | -75 | 2 | Guinea pig | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 769 | 11 | 5 | 5 | 6.7 | O=C(O)c1cc(NC(=O)[C@@H](Cc2cccc(F)c2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm00021a019 | |||
CHEMBL433656 | 175018 | 0 | None | -75 | 2 | Guinea pig | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 769 | 11 | 5 | 5 | 6.7 | O=C(O)c1cc(NC(=O)[C@@H](Cc2cccc(F)c2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm00021a019 | |||
44356666 | 175408 | 0 | None | -16 | 2 | Guinea pig | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 799 | 11 | 3 | 11 | 5.2 | O=C(NCC12CC3CC(CC(C3)C1)C2)C1C2c3ccccc3C(c3ccccc32)C1C(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1cc(-n2cnnn2)cc(-n2cnnn2)c1 | 10.1021/jm00021a019 | |||
CHEMBL436187 | 175408 | 0 | None | -16 | 2 | Guinea pig | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 799 | 11 | 3 | 11 | 5.2 | O=C(NCC12CC3CC(CC(C3)C1)C2)C1C2c3ccccc3C(c3ccccc32)C1C(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1cc(-n2cnnn2)cc(-n2cnnn2)c1 | 10.1021/jm00021a019 | |||
11643045 | 78913 | 0 | None | -43 | 3 | Guinea pig | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 511 | 9 | 3 | 3 | 6.8 | Cc1ccccc1-c1nc(C(=O)Nc2cccc(CCC(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 | 10.1021/jm0490686 | |||
CHEMBL197873 | 78913 | 0 | None | -43 | 3 | Guinea pig | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 511 | 9 | 3 | 3 | 6.8 | Cc1ccccc1-c1nc(C(=O)Nc2cccc(CCC(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 | 10.1021/jm0490686 | |||
10793342 | 119882 | 0 | None | -158 | 2 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 579 | 6 | 2 | 5 | 6.0 | O=C(Nc1cccc([N+](=O)[O-])c1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O | 10.1021/jm990967h | |||
CHEMBL331405 | 119882 | 0 | None | -158 | 2 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 579 | 6 | 2 | 5 | 6.0 | O=C(Nc1cccc([N+](=O)[O-])c1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O | 10.1021/jm990967h | |||
44329798 | 114326 | 0 | None | -245 | 5 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 610 | 10 | 2 | 4 | 6.5 | CC(Cc1c[nH]c2ccccc12)(C(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccc(Cl)cc1Cl)CC(=O)O | 10.1021/jm00072a005 | |||
CHEMBL318852 | 114326 | 0 | None | -245 | 5 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 610 | 10 | 2 | 4 | 6.5 | CC(Cc1c[nH]c2ccccc12)(C(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccc(Cl)cc1Cl)CC(=O)O | 10.1021/jm00072a005 | |||
19700615 | 70928 | 0 | None | - | 1 | Rat | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 589 | 7 | 2 | 5 | 4.2 | O=C(Nc1ccccc1)NC1C(=O)N(CCN2CCOCC2)c2cc(F)ccc2N(CC23CC4CC(CC(C4)C2)C3)C1=O | 10.1016/j.bmc.2011.05.057 | |||
CHEMBL1808417 | 70928 | 0 | None | - | 1 | Rat | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 589 | 7 | 2 | 5 | 4.2 | O=C(Nc1ccccc1)NC1C(=O)N(CCN2CCOCC2)c2cc(F)ccc2N(CC23CC4CC(CC(C4)C2)C3)C1=O | 10.1016/j.bmc.2011.05.057 | |||
887 | 10882 | 33 | None | -380 | 4 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 498 | 6 | 3 | 6 | 4.1 | CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 | 10.1016/j.bmc.2007.12.047 | |||
9870520 | 10882 | 33 | None | -380 | 4 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 498 | 6 | 3 | 6 | 4.1 | CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 | 10.1016/j.bmc.2007.12.047 | |||
CHEMBL324547 | 10882 | 33 | None | -380 | 4 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 498 | 6 | 3 | 6 | 4.1 | CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 | 10.1016/j.bmc.2007.12.047 | |||
DB12355 | 10882 | 33 | None | -380 | 4 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 498 | 6 | 3 | 6 | 4.1 | CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 | 10.1016/j.bmc.2007.12.047 | |||
11534594 | 205579 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 616 | 8 | 2 | 6 | 7.0 | O=C(NCC(c1ccc(Cl)cc1)c1ccc(Cl)cc1)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 | 10.1016/j.bmcl.2009.09.064 | |||
CHEMBL583343 | 205579 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 616 | 8 | 2 | 6 | 7.0 | O=C(NCC(c1ccc(Cl)cc1)c1ccc(Cl)cc1)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 | 10.1016/j.bmcl.2009.09.064 | |||
10071178 | 81270 | 2 | None | 501 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 427 | 7 | 4 | 3 | 3.8 | O=C(Nc1ccccc1C(=O)NC(Cc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 | 10.1021/jm060590x | |||
CHEMBL202861 | 81270 | 2 | None | 501 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 427 | 7 | 4 | 3 | 3.8 | O=C(Nc1ccccc1C(=O)NC(Cc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 | 10.1021/jm060590x | |||
CHEMBL3350665 | 218261 | 0 | None | -3 | 2 | Guinea pig | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00174a016 | |||||
44272041 | 103858 | 0 | None | -338 | 2 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 1274 | 26 | 13 | 15 | 2.1 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc2ccc(OS(=O)(=O)O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00126a007 | |||
CHEMBL267329 | 103858 | 0 | None | -338 | 2 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 1274 | 26 | 13 | 15 | 2.1 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc2ccc(OS(=O)(=O)O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00126a007 | |||
10459641 | 119015 | 0 | None | -26 | 2 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 529 | 9 | 3 | 4 | 5.4 | COc1ccc(CCNC(=O)C(C)(Cc2c[nH]c3ccccc23)NC(=O)OC2[C@H]3C[C@@H]4C[C@@H](C[C@H]2C4)C3)cc1 | 10.1021/jm00072a005 | |||
CHEMBL329088 | 119015 | 0 | None | -26 | 2 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 529 | 9 | 3 | 4 | 5.4 | COc1ccc(CCNC(=O)C(C)(Cc2c[nH]c3ccccc23)NC(=O)OC2[C@H]3C[C@@H]4C[C@@H](C[C@H]2C4)C3)cc1 | 10.1021/jm00072a005 | |||
45486968 | 204248 | 0 | None | 1 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 550 | 8 | 3 | 7 | 4.2 | O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 | 10.1016/j.bmcl.2009.09.064 | |||
CHEMBL569848 | 204248 | 0 | None | 1 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 550 | 8 | 3 | 7 | 4.2 | O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 | 10.1016/j.bmcl.2009.09.064 | |||
45486985 | 204532 | 0 | None | -63 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 650 | 8 | 3 | 6 | 4.5 | O=C(N[C@@H](Cc1ccc(F)c(Br)c1)C(=O)O)c1ccc(Br)cc1NS(=O)(=O)c1cccc2nccnc12 | 10.1016/j.bmcl.2009.09.065 | |||
CHEMBL571650 | 204532 | 0 | None | -63 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 650 | 8 | 3 | 6 | 4.5 | O=C(N[C@@H](Cc1ccc(F)c(Br)c1)C(=O)O)c1ccc(Br)cc1NS(=O)(=O)c1cccc2nccnc12 | 10.1016/j.bmcl.2009.09.065 | |||
10411553 | 160674 | 0 | None | - | 1 | Guinea pig | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 452 | 4 | 3 | 6 | 2.8 | CN1C(=O)[C@H](NC(=O)Nc2cccc(-c3nnn[nH]3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm070880t | |||
CHEMBL398312 | 160674 | 0 | None | - | 1 | Guinea pig | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 452 | 4 | 3 | 6 | 2.8 | CN1C(=O)[C@H](NC(=O)Nc2cccc(-c3nnn[nH]3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm070880t | |||
5311201 | 214174 | 35 | None | -2570 | 6 | Guinea pig | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm070880t | |||
CHEMBL9387 | 214174 | 35 | None | -2570 | 6 | Guinea pig | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm070880t | |||
136036823 | 162457 | 0 | None | -263 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 574 | 7 | 2 | 7 | 4.8 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nc(=O)o[nH]3)c2)C(=O)N(C2CCCCC2)c2ccccc21 | 10.1016/j.bmc.2007.12.047 | |||
CHEMBL404967 | 162457 | 0 | None | -263 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 574 | 7 | 2 | 7 | 4.8 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nc(=O)o[nH]3)c2)C(=O)N(C2CCCCC2)c2ccccc21 | 10.1016/j.bmc.2007.12.047 | |||
10099495 | 114510 | 0 | None | -117 | 2 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 567 | 8 | 3 | 3 | 6.7 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccc(Cl)cc1Cl | 10.1021/jm00072a005 | |||
CHEMBL319120 | 114510 | 0 | None | -117 | 2 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 567 | 8 | 3 | 3 | 6.7 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccc(Cl)cc1Cl | 10.1021/jm00072a005 | |||
45486958 | 204367 | 0 | None | -19 | 2 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 516 | 8 | 3 | 7 | 3.6 | O=C(N[C@H](Cc1ccccc1)C(=O)O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 | 10.1016/j.bmcl.2009.09.064 | |||
CHEMBL570518 | 204367 | 0 | None | -19 | 2 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 516 | 8 | 3 | 7 | 3.6 | O=C(N[C@H](Cc1ccccc1)C(=O)O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 | 10.1016/j.bmcl.2009.09.064 | |||
44444928 | 161395 | 0 | None | - | 1 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 610 | 10 | 6 | 5 | 5.0 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3cc[nH]c3cc2C(=O)NC2CCCCCC2)cc(C(=O)O)c1 | 10.1021/jm070880t | |||
CHEMBL399252 | 161395 | 0 | None | - | 1 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 610 | 10 | 6 | 5 | 5.0 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3cc[nH]c3cc2C(=O)NC2CCCCCC2)cc(C(=O)O)c1 | 10.1021/jm070880t | |||
16090699 | 148694 | 0 | None | 1 | 2 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 463 | 8 | 4 | 4 | 3.4 | O=C(N[C@@H](Cc1ccccc1)C(=O)O)c1ccccc1NS(=O)(=O)c1cc2ccccc2[nH]1 | 10.1021/jm060590x | |||
CHEMBL386985 | 148694 | 0 | None | 1 | 2 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 463 | 8 | 4 | 4 | 3.4 | O=C(N[C@@H](Cc1ccccc1)C(=O)O)c1ccccc1NS(=O)(=O)c1cc2ccccc2[nH]1 | 10.1021/jm060590x | |||
10603971 | 108392 | 0 | None | -208 | 2 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 624 | 11 | 6 | 5 | 5.2 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3cc[nH]c3cc2C(=O)NCC2CCCCCC2)cc(C(=O)O)c1 | 10.1021/jm9508907 | |||
CHEMBL298861 | 108392 | 0 | None | -208 | 2 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 624 | 11 | 6 | 5 | 5.2 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3cc[nH]c3cc2C(=O)NCC2CCCCCC2)cc(C(=O)O)c1 | 10.1021/jm9508907 | |||
9958028 | 18576 | 0 | None | -12 | 2 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 511 | 7 | 4 | 4 | 6.4 | O=C(O)c1cc(NC(=O)c2[nH]c(-c3ccc4ccccc4c3)nc2CC2CCCCCC2)cc(C(=O)O)c1 | 10.1021/jm049069y | |||
CHEMBL1181937 | 18576 | 0 | None | -12 | 2 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 511 | 7 | 4 | 4 | 6.4 | O=C(O)c1cc(NC(=O)c2[nH]c(-c3ccc4ccccc4c3)nc2CC2CCCCCC2)cc(C(=O)O)c1 | 10.1021/jm049069y | |||
CHEMBL2067950 | 18576 | 0 | None | -12 | 2 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 511 | 7 | 4 | 4 | 6.4 | O=C(O)c1cc(NC(=O)c2[nH]c(-c3ccc4ccccc4c3)nc2CC2CCCCCC2)cc(C(=O)O)c1 | 10.1021/jm049069y | |||
9956948 | 18700 | 0 | None | 1 | 2 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 483 | 7 | 4 | 4 | 6.0 | O=C(Nc1cc(CO)cc(CO)c1)c1[nH]c(-c2ccc3ccccc3c2)nc1CC1CCCCCC1 | 10.1021/jm049069y | |||
CHEMBL1182723 | 18700 | 0 | None | 1 | 2 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 483 | 7 | 4 | 4 | 6.0 | O=C(Nc1cc(CO)cc(CO)c1)c1[nH]c(-c2ccc3ccccc3c2)nc1CC1CCCCCC1 | 10.1021/jm049069y | |||
CHEMBL2067953 | 18700 | 0 | None | 1 | 2 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 483 | 7 | 4 | 4 | 6.0 | O=C(Nc1cc(CO)cc(CO)c1)c1[nH]c(-c2ccc3ccccc3c2)nc1CC1CCCCCC1 | 10.1021/jm049069y | |||
11576933 | 19040 | 0 | None | -19 | 2 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 499 | 7 | 4 | 4 | 5.5 | O=C(O)c1cc(NC(=O)c2[nH]c(-c3ccccc3)nc2CC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm049069y | |||
CHEMBL1184725 | 19040 | 0 | None | -19 | 2 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 499 | 7 | 4 | 4 | 5.5 | O=C(O)c1cc(NC(=O)c2[nH]c(-c3ccccc3)nc2CC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm049069y | |||
CHEMBL2067957 | 19040 | 0 | None | -19 | 2 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 499 | 7 | 4 | 4 | 5.5 | O=C(O)c1cc(NC(=O)c2[nH]c(-c3ccccc3)nc2CC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm049069y | |||
44404005 | 19057 | 0 | None | -100 | 2 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 623 | 11 | 5 | 5 | 5.0 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2ccccc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm049069y | |||
CHEMBL1184845 | 19057 | 0 | None | -100 | 2 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 623 | 11 | 5 | 5 | 5.0 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2ccccc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm049069y | |||
CHEMBL2067963 | 19057 | 0 | None | -100 | 2 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 623 | 11 | 5 | 5 | 5.0 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2ccccc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm049069y | |||
CHEMBL206974 | 215961 | 0 | None | -72 | 5 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm0303103 | |||||
CHEMBL1172249 | 215361 | 0 | None | -5 | 4 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H]1Cc2ccccc2CN1C(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/j.bmcl.2010.05.078 | |||||
CHEMBL206974 | 215961 | 0 | None | -72 | 5 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm050921q | |||||
CHEMBL3351048 | 218311 | 0 | None | -5 | 2 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | None | None | None | CN(C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1ccccc1)[C@@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C | 10.1021/jm00053a022 | |||||
CHEMBL407057 | 219414 | 0 | None | -1513 | 4 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O | 10.1021/jm050921q | |||||
11513177 | 79304 | 0 | None | -131 | 3 | Guinea pig | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 501 | 7 | 3 | 3 | 6.7 | O=C(O)c1cccc(NC(=O)c2[nH]c(C34CCC(CC3)CC4)nc2CCC23CC4CC(CC(C4)C2)C3)c1 | 10.1021/jm0490686 | |||
CHEMBL199091 | 79304 | 0 | None | -131 | 3 | Guinea pig | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 501 | 7 | 3 | 3 | 6.7 | O=C(O)c1cccc(NC(=O)c2[nH]c(C34CCC(CC3)CC4)nc2CCC23CC4CC(CC(C4)C2)C3)c1 | 10.1021/jm0490686 | |||
10004216 | 11515 | 0 | None | -11 | 2 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 456 | 6 | 2 | 3 | 4.9 | CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21 | 10.1021/jm990967h | |||
CHEMBL103750 | 11515 | 0 | None | -11 | 2 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 456 | 6 | 2 | 3 | 4.9 | CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21 | 10.1021/jm990967h | |||
18472063 | 70931 | 0 | None | - | 1 | Rat | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 529 | 7 | 2 | 4 | 4.3 | CN(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc21 | 10.1016/j.bmc.2011.05.057 | |||
CHEMBL1808420 | 70931 | 0 | None | - | 1 | Rat | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 529 | 7 | 2 | 4 | 4.3 | CN(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc21 | 10.1016/j.bmc.2011.05.057 | |||
CHEMBL1206136 | 215383 | 0 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCCC)NC(=O)[C@@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00122a026 | |||||
CHEMBL218455 | 215383 | 0 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCCC)NC(=O)[C@@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00122a026 | |||||
54554106 | 70922 | 0 | None | - | 1 | Rat | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 451 | 8 | 2 | 4 | 3.2 | CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(CCN(C)C)c2ccccc21 | 10.1016/j.bmc.2011.05.057 | |||
CHEMBL1808411 | 70922 | 0 | None | - | 1 | Rat | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 451 | 8 | 2 | 4 | 3.2 | CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(CCN(C)C)c2ccccc21 | 10.1016/j.bmc.2011.05.057 | |||
10723216 | 168774 | 0 | None | -4466 | 2 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 680 | 11 | 6 | 5 | 5.6 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2F)NC(=O)c2cc3cc[nH]c3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm9508907 | |||
CHEMBL415936 | 168774 | 0 | None | -4466 | 2 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 680 | 11 | 6 | 5 | 5.6 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2F)NC(=O)c2cc3cc[nH]c3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm9508907 | |||
CHEMBL265595 | 217434 | 0 | None | -1584 | 4 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O | 10.1021/jm0303103 | |||||
10604664 | 162014 | 0 | None | -602 | 2 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 691 | 9 | 2 | 7 | 5.6 | O=C(Nc1cccc(C(=O)OCCN2CCOCC2)c1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O | 10.1021/jm990967h | |||
CHEMBL402702 | 162014 | 0 | None | -602 | 2 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 691 | 9 | 2 | 7 | 5.6 | O=C(Nc1cccc(C(=O)OCCN2CCOCC2)c1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O | 10.1021/jm990967h | |||
10580234 | 105810 | 0 | None | -251 | 2 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 662 | 11 | 6 | 5 | 5.5 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3[nH]ccc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm9508907 | |||
CHEMBL280248 | 105810 | 0 | None | -251 | 2 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 662 | 11 | 6 | 5 | 5.5 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3[nH]ccc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm9508907 | |||
CHEMBL3350331 | 218252 | 0 | None | 1 | 2 | Guinea pig | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | None | None | None | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00174a016 | |||||
CHEMBL3350665 | 218261 | 0 | None | -3 | 2 | Guinea pig | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00174a016 | |||||
44265916 | 214374 | 0 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 352 | 5 | 2 | 1 | 5.0 | O=C(NCC=C(c1ccccc1)c1ccccc1)c1cc2ccccc2[nH]1 | 10.1021/jm00084a009 | |||
CHEMBL9500 | 214374 | 0 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 352 | 5 | 2 | 1 | 5.0 | O=C(NCC=C(c1ccccc1)c1ccccc1)c1cc2ccccc2[nH]1 | 10.1021/jm00084a009 | |||
CHEMBL2371662 | 216885 | 0 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00389a002 | |||||
10031454 | 115365 | 0 | None | -67 | 2 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 596 | 10 | 2 | 4 | 5.5 | CC(Cc1ccc(Br)cc1)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccc1)CC(=O)O | 10.1021/jm00072a005 | |||
CHEMBL320399 | 115365 | 0 | None | -67 | 2 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 596 | 10 | 2 | 4 | 5.5 | CC(Cc1ccc(Br)cc1)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccc1)CC(=O)O | 10.1021/jm00072a005 | |||
56659684 | 70925 | 0 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 519 | 7 | 2 | 5 | 3.5 | O=C(Nc1ccccc1)NC1C(=O)N(CCN2CCOCC2)c2ccccc2N(CC2CCCCC2)C1=O | 10.1016/j.bmc.2011.05.057 | |||
CHEMBL1808414 | 70925 | 0 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 519 | 7 | 2 | 5 | 3.5 | O=C(Nc1ccccc1)NC1C(=O)N(CCN2CCOCC2)c2ccccc2N(CC2CCCCC2)C1=O | 10.1016/j.bmc.2011.05.057 | |||
10508004 | 18571 | 0 | None | -2454 | 2 | Rat | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 612 | 5 | 2 | 3 | 6.9 | O=C(Nc1ccc(Br)cc1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O | 10.1021/jm990967h | |||
CHEMBL118189 | 18571 | 0 | None | -2454 | 2 | Rat | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 612 | 5 | 2 | 3 | 6.9 | O=C(Nc1ccc(Br)cc1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O | 10.1021/jm990967h | |||
44382456 | 127239 | 0 | None | -3162 | 3 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 572 | 10 | 5 | 5 | 4.8 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccc(N)cc1 | 10.1016/S0960-894X(00)80686-1 | |||
CHEMBL354049 | 127239 | 0 | None | -3162 | 3 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 572 | 10 | 5 | 5 | 4.8 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccc(N)cc1 | 10.1016/S0960-894X(00)80686-1 | |||
CHEMBL83942 | 127239 | 0 | None | -3162 | 3 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 572 | 10 | 5 | 5 | 4.8 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccc(N)cc1 | 10.1016/S0960-894X(00)80686-1 | |||
CHEMBL3351061 | 218321 | 0 | None | -4 | 2 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | None | None | None | CN(C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1cccc2ccccc12)[C@@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C | 10.1021/jm00053a022 | |||||
9867157 | 107018 | 7 | None | 194 | 2 | Guinea pig | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 426 | 9 | 3 | 4 | 2.3 | O=C(O)C[C@H](NS(=O)(=O)c1ccc2ccccc2c1)C(=O)NCCc1ccccc1 | 10.1016/S0960-894X(00)80008-6 | |||
CHEMBL288641 | 107018 | 7 | None | 194 | 2 | Guinea pig | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 426 | 9 | 3 | 4 | 2.3 | O=C(O)C[C@H](NS(=O)(=O)c1ccc2ccccc2c1)C(=O)NCCc1ccccc1 | 10.1016/S0960-894X(00)80008-6 | |||
44356825 | 175412 | 0 | None | -1621 | 2 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 767 | 11 | 6 | 6 | 6.3 | O=C(O)c1cc(NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm00021a019 | |||
CHEMBL436209 | 175412 | 0 | None | -1621 | 2 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 767 | 11 | 6 | 6 | 6.3 | O=C(O)c1cc(NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm00021a019 | |||
11798204 | 201372 | 0 | None | -10 | 2 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 460 | 5 | 2 | 3 | 4.5 | O=C(NCC12CC3CC(CC(C3)C1)C2)c1cc2ccccc2cc1C(=O)N1CCC[C@@H]1C(=O)O | 10.1021/jm9508907 | |||
CHEMBL53129 | 201372 | 0 | None | -10 | 2 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 460 | 5 | 2 | 3 | 4.5 | O=C(NCC12CC3CC(CC(C3)C1)C2)c1cc2ccccc2cc1C(=O)N1CCC[C@@H]1C(=O)O | 10.1021/jm9508907 | |||
10815832 | 21954 | 0 | None | -109 | 2 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 520 | 7 | 2 | 4 | 5.8 | CSc1cccc(NC(=O)NC2C(=O)N(CCC(C)C)c3ccccc3N(c3ccccc3F)C2=O)c1 | 10.1021/jm990967h | |||
CHEMBL121021 | 21954 | 0 | None | -109 | 2 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 520 | 7 | 2 | 4 | 5.8 | CSc1cccc(NC(=O)NC2C(=O)N(CCC(C)C)c3ccccc3N(c3ccccc3F)C2=O)c1 | 10.1021/jm990967h | |||
CHEMBL218763 | 216178 | 0 | None | -3630 | 4 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm050921q | |||||
CHEMBL120632 | 215384 | 33 | None | -2187 | 3 | Guinea pig | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm0000416 | |||||
CHEMBL120632 | 215384 | 33 | None | -2187 | 3 | Guinea pig | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm9603072 | |||||
9939572 | 44265 | 0 | None | -3548 | 3 | Guinea pig | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 662 | 11 | 6 | 5 | 5.5 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3cc[nH]c3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm9508907 | |||
CHEMBL14557 | 44265 | 0 | None | -3548 | 3 | Guinea pig | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 662 | 11 | 6 | 5 | 5.5 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3cc[nH]c3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm9508907 | |||
CHEMBL2067949 | 44265 | 0 | None | -3548 | 3 | Guinea pig | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 662 | 11 | 6 | 5 | 5.5 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3cc[nH]c3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm9508907 | |||
16731711 | 92294 | 0 | None | -15 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 570 | 7 | 2 | 5 | 5.8 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C23CC4CC(CC(C4)C2)C3)c2ccccc21 | 10.1021/jm070139l | |||
CHEMBL227369 | 92294 | 0 | None | -15 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 570 | 7 | 2 | 5 | 5.8 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C23CC4CC(CC(C4)C2)C3)c2ccccc21 | 10.1021/jm070139l | |||
10676212 | 122787 | 0 | None | -489 | 2 | Guinea pig | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 701 | 8 | 4 | 5 | 5.9 | O=C(O)c1cc(NC(=O)[C@H]2CCCN2C(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm00021a019 | |||
CHEMBL335587 | 122787 | 0 | None | -489 | 2 | Guinea pig | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 701 | 8 | 4 | 5 | 5.9 | O=C(O)c1cc(NC(=O)[C@H]2CCCN2C(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm00021a019 | |||
44280162 | 106232 | 0 | None | -21 | 2 | Guinea pig | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 667 | 8 | 3 | 5 | 6.9 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1CC[C@H](Oc2ccc(Cl)cc2Cl)C[C@@H]1C(=O)O | 10.1016/s0960-894x(98)00231-5 | |||
CHEMBL283040 | 106232 | 0 | None | -21 | 2 | Guinea pig | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 667 | 8 | 3 | 5 | 6.9 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1CC[C@H](Oc2ccc(Cl)cc2Cl)C[C@@H]1C(=O)O | 10.1016/s0960-894x(98)00231-5 | |||
10324322 | 114482 | 0 | None | -43 | 2 | Guinea pig | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 518 | 10 | 2 | 4 | 4.7 | CC(Cc1ccccc1)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccc1)CC(=O)O | 10.1021/jm00072a005 | |||
CHEMBL319085 | 114482 | 0 | None | -43 | 2 | Guinea pig | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 518 | 10 | 2 | 4 | 4.7 | CC(Cc1ccccc1)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccc1)CC(=O)O | 10.1021/jm00072a005 | |||
10484529 | 108210 | 0 | None | -707 | 2 | Guinea pig | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 663 | 11 | 5 | 6 | 5.8 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3ccoc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm9508907 | |||
CHEMBL297480 | 108210 | 0 | None | -707 | 2 | Guinea pig | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 663 | 11 | 5 | 6 | 5.8 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3ccoc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm9508907 | |||
44272042 | 103821 | 0 | None | -131 | 2 | Guinea pig | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 1274 | 26 | 13 | 15 | 2.1 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCCNC(=O)CC[C@@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc2ccc(OS(=O)(=O)O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00126a007 | |||
CHEMBL266990 | 103821 | 0 | None | -131 | 2 | Guinea pig | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 1274 | 26 | 13 | 15 | 2.1 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCCNC(=O)CC[C@@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc2ccc(OS(=O)(=O)O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00126a007 | |||
16732021 | 175255 | 0 | None | -549 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 588 | 9 | 2 | 8 | 5.3 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(SCc3nn[nH]n3)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
CHEMBL435143 | 175255 | 0 | None | -549 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 588 | 9 | 2 | 8 | 5.3 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(SCc3nn[nH]n3)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
44451843 | 166218 | 0 | None | -1230 | 3 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 562 | 8 | 2 | 5 | 5.5 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CC(=O)O)c2)C(=O)N(C2CCCCCC2)c2ccccc21 | 10.1016/j.bmc.2007.12.047 | |||
CHEMBL410114 | 166218 | 0 | None | -1230 | 3 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 562 | 8 | 2 | 5 | 5.5 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CC(=O)O)c2)C(=O)N(C2CCCCCC2)c2ccccc21 | 10.1016/j.bmc.2007.12.047 | |||
53465844 | 76186 | 0 | None | 131 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 441 | 8 | 4 | 3 | 4.2 | O=C(Nc1ccccc1C(=O)N[C@H](CCc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 | 10.1021/jm200438b | |||
CHEMBL1933104 | 76186 | 0 | None | 131 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 441 | 8 | 4 | 3 | 4.2 | O=C(Nc1ccccc1C(=O)N[C@H](CCc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 | 10.1021/jm200438b | |||
CHEMBL132314 | 215481 | 0 | None | -6456 | 4 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm0303103 | |||||
44461961 | 112386 | 0 | None | -446 | 3 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 724 | 11 | 4 | 5 | 6.8 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccc(N=[N+]=[N-])c(I)c1 | 10.1016/0960-894X(95)00435-V | |||
CHEMBL2079605 | 112386 | 0 | None | -446 | 3 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 724 | 11 | 4 | 5 | 6.8 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccc(N=[N+]=[N-])c(I)c1 | 10.1016/0960-894X(95)00435-V | |||
CHEMBL312252 | 112386 | 0 | None | -446 | 3 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 724 | 11 | 4 | 5 | 6.8 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccc(N=[N+]=[N-])c(I)c1 | 10.1016/0960-894X(95)00435-V | |||
11547802 | 142781 | 0 | None | -177 | 2 | Guinea pig | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 497 | 8 | 3 | 3 | 6.4 | Cc1ccccc1-c1nc(C(=O)Nc2cccc(CC(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 | 10.1021/jm0490686 | |||
CHEMBL373168 | 142781 | 0 | None | -177 | 2 | Guinea pig | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 497 | 8 | 3 | 3 | 6.4 | Cc1ccccc1-c1nc(C(=O)Nc2cccc(CC(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 | 10.1021/jm0490686 | |||
45486941 | 203543 | 0 | None | 1 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 516 | 7 | 2 | 6 | 4.2 | O=C(NCCc1ccccc1)c1ccc(Br)cc1NS(=O)(=O)c1cccc2nsnc12 | 10.1016/j.bmcl.2009.09.064 | |||
CHEMBL565325 | 203543 | 0 | None | 1 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 516 | 7 | 2 | 6 | 4.2 | O=C(NCCc1ccccc1)c1ccc(Br)cc1NS(=O)(=O)c1cccc2nsnc12 | 10.1016/j.bmcl.2009.09.064 | |||
45486964 | 204173 | 0 | None | -39 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 606 | 8 | 3 | 6 | 4.4 | O=C(N[C@@H](Cc1ccc(F)c(Br)c1)C(=O)O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nccnc12 | 10.1016/j.bmcl.2009.09.065 | |||
CHEMBL569391 | 204173 | 0 | None | -39 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 606 | 8 | 3 | 6 | 4.4 | O=C(N[C@@H](Cc1ccc(F)c(Br)c1)C(=O)O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nccnc12 | 10.1016/j.bmcl.2009.09.065 | |||
887 | 10882 | 33 | None | -5011 | 4 | Guinea pig | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 498 | 6 | 3 | 6 | 4.1 | CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 | 10.1021/jm070880t | |||
9870520 | 10882 | 33 | None | -5011 | 4 | Guinea pig | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 498 | 6 | 3 | 6 | 4.1 | CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 | 10.1021/jm070880t | |||
CHEMBL324547 | 10882 | 33 | None | -5011 | 4 | Guinea pig | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 498 | 6 | 3 | 6 | 4.1 | CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 | 10.1021/jm070880t | |||
DB12355 | 10882 | 33 | None | -5011 | 4 | Guinea pig | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 498 | 6 | 3 | 6 | 4.1 | CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 | 10.1021/jm070880t | |||
45486949 | 203724 | 0 | None | -50 | 2 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 516 | 8 | 3 | 7 | 3.6 | O=C(N[C@@H](Cc1ccccc1)C(=O)O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 | 10.1016/j.bmcl.2009.09.064 | |||
CHEMBL566390 | 203724 | 0 | None | -50 | 2 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 516 | 8 | 3 | 7 | 3.6 | O=C(N[C@@H](Cc1ccccc1)C(=O)O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 | 10.1016/j.bmcl.2009.09.064 | |||
45486970 | 204408 | 0 | None | -3 | 2 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 578 | 8 | 3 | 7 | 5.0 | CC(C)(c1ccc(Cl)cc1)[C@H](NC(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)C(=O)O | 10.1016/j.bmcl.2009.09.064 | |||
CHEMBL570761 | 204408 | 0 | None | -3 | 2 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 578 | 8 | 3 | 7 | 5.0 | CC(C)(c1ccc(Cl)cc1)[C@H](NC(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)C(=O)O | 10.1016/j.bmcl.2009.09.064 | |||
45486997 | 204562 | 0 | None | -12 | 2 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 486 | 7 | 1 | 6 | 4.5 | CN(CCc1ccccc1)C(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 | 10.1016/j.bmcl.2009.09.064 | |||
CHEMBL571832 | 204562 | 0 | None | -12 | 2 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 486 | 7 | 1 | 6 | 4.5 | CN(CCc1ccccc1)C(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 | 10.1016/j.bmcl.2009.09.064 | |||
9939572 | 44265 | 0 | None | -3548 | 3 | Guinea pig | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 662 | 11 | 6 | 5 | 5.5 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3cc[nH]c3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm070880t | |||
CHEMBL14557 | 44265 | 0 | None | -3548 | 3 | Guinea pig | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 662 | 11 | 6 | 5 | 5.5 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3cc[nH]c3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm070880t | |||
CHEMBL2067949 | 44265 | 0 | None | -3548 | 3 | Guinea pig | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 662 | 11 | 6 | 5 | 5.5 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3cc[nH]c3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm070880t | |||
10327180 | 44408 | 0 | None | - | 1 | Guinea pig | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 676 | 11 | 5 | 6 | 5.5 | Cn1ccc2cc(C(=O)N[C@@H](Cc3ccccc3)C(=O)Nc3cc(C(=O)O)cc(C(=O)O)c3)c(C(=O)NCC34CC5CC(CC(C5)C3)C4)cc21 | 10.1021/jm070880t | |||
CHEMBL14571 | 44408 | 0 | None | - | 1 | Guinea pig | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 676 | 11 | 5 | 6 | 5.5 | Cn1ccc2cc(C(=O)N[C@@H](Cc3ccccc3)C(=O)Nc3cc(C(=O)O)cc(C(=O)O)c3)c(C(=O)NCC34CC5CC(CC(C5)C3)C4)cc21 | 10.1021/jm070880t | |||
44425006 | 148858 | 0 | None | -3311 | 2 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 544 | 8 | 2 | 5 | 5.6 | CC1CCCC1C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
CHEMBL388068 | 148858 | 0 | None | -3311 | 2 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 544 | 8 | 2 | 5 | 5.6 | CC1CCCC1C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
44404001 | 18705 | 0 | None | -6 | 2 | Guinea pig | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 635 | 11 | 6 | 6 | 4.5 | O=C(NCC12CC3CC(CC(C3)C1)C2)c1cc2nc[nH]c2cc1C(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1cc(CO)cc(CO)c1 | 10.1021/jm049069y | |||
CHEMBL1182744 | 18705 | 0 | None | -6 | 2 | Guinea pig | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 635 | 11 | 6 | 6 | 4.5 | O=C(NCC12CC3CC(CC(C3)C1)C2)c1cc2nc[nH]c2cc1C(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1cc(CO)cc(CO)c1 | 10.1021/jm049069y | |||
CHEMBL2067969 | 18705 | 0 | None | -6 | 2 | Guinea pig | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 635 | 11 | 6 | 6 | 4.5 | O=C(NCC12CC3CC(CC(C3)C1)C2)c1cc2nc[nH]c2cc1C(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1cc(CO)cc(CO)c1 | 10.1021/jm049069y | |||
44403982 | 19050 | 0 | None | -7 | 2 | Guinea pig | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 677 | 11 | 5 | 6 | 4.9 | CN(C(=O)[C@H](Cc1ccccc1)NC(=O)c1cc2[nH]cnc2cc1C(=O)NCC12CC3CC(CC(C3)C1)C2)c1cc(C(=O)O)cc(C(=O)O)c1 | 10.1021/jm049069y | |||
CHEMBL1184798 | 19050 | 0 | None | -7 | 2 | Guinea pig | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 677 | 11 | 5 | 6 | 4.9 | CN(C(=O)[C@H](Cc1ccccc1)NC(=O)c1cc2[nH]cnc2cc1C(=O)NCC12CC3CC(CC(C3)C1)C2)c1cc(C(=O)O)cc(C(=O)O)c1 | 10.1021/jm049069y | |||
CHEMBL2067958 | 19050 | 0 | None | -7 | 2 | Guinea pig | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 677 | 11 | 5 | 6 | 4.9 | CN(C(=O)[C@H](Cc1ccccc1)NC(=O)c1cc2[nH]cnc2cc1C(=O)NCC12CC3CC(CC(C3)C1)C2)c1cc(C(=O)O)cc(C(=O)O)c1 | 10.1021/jm049069y | |||
9939572 | 44265 | 0 | None | -3548 | 3 | Guinea pig | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 662 | 11 | 6 | 5 | 5.5 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3cc[nH]c3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm049069y | |||
CHEMBL14557 | 44265 | 0 | None | -3548 | 3 | Guinea pig | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 662 | 11 | 6 | 5 | 5.5 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3cc[nH]c3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm049069y | |||
CHEMBL2067949 | 44265 | 0 | None | -3548 | 3 | Guinea pig | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 662 | 11 | 6 | 5 | 5.5 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3cc[nH]c3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm049069y | |||
9890720 | 175249 | 0 | None | -2 | 2 | Guinea pig | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 466 | 6 | 3 | 2 | 7.3 | O=C(O)c1cccc(NC(=O)c2cc(-c3ccc4ccccc4c3)[nH]c2CC2CCCCCC2)c1 | 10.1021/jm049069y | |||
CHEMBL2067971 | 175249 | 0 | None | -2 | 2 | Guinea pig | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 466 | 6 | 3 | 2 | 7.3 | O=C(O)c1cccc(NC(=O)c2cc(-c3ccc4ccccc4c3)[nH]c2CC2CCCCCC2)c1 | 10.1021/jm049069y | |||
CHEMBL435127 | 175249 | 0 | None | -2 | 2 | Guinea pig | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 466 | 6 | 3 | 2 | 7.3 | O=C(O)c1cccc(NC(=O)c2cc(-c3ccc4ccccc4c3)[nH]c2CC2CCCCCC2)c1 | 10.1021/jm049069y | |||
10509945 | 96159 | 0 | None | 229 | 2 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 896 | 26 | 9 | 9 | 2.1 | CCCC[C@H](NC(=O)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm990252e | |||
CHEMBL2369816 | 96159 | 0 | None | 229 | 2 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 896 | 26 | 9 | 9 | 2.1 | CCCC[C@H](NC(=O)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm990252e | |||
CHEMBL384035 | 219095 | 4 | None | -22 | 4 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00389a002 | |||||
CHEMBL428666 | 219095 | 4 | None | -22 | 4 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00389a002 | |||||
10508430 | 23111 | 0 | None | - | 1 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 648 | 18 | 6 | 6 | 1.8 | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC | 10.1021/jm0000416 | |||
CHEMBL122872 | 23111 | 0 | None | - | 1 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 648 | 18 | 6 | 6 | 1.8 | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC | 10.1021/jm0000416 | |||
44332766 | 115113 | 0 | None | 48 | 2 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 474 | 6 | 2 | 3 | 5.1 | CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2cc(F)ccc21 | 10.1016/0960-894X(95)00528-2 | |||
CHEMBL319795 | 115113 | 0 | None | 48 | 2 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 474 | 6 | 2 | 3 | 5.1 | CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2cc(F)ccc21 | 10.1016/0960-894X(95)00528-2 | |||
19043395 | 11545 | 0 | None | 194 | 2 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 490 | 6 | 2 | 3 | 5.6 | CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2cc(Cl)ccc21 | 10.1016/0960-894X(95)00528-2 | |||
CHEMBL103968 | 11545 | 0 | None | 194 | 2 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 490 | 6 | 2 | 3 | 5.6 | CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2cc(Cl)ccc21 | 10.1016/0960-894X(95)00528-2 | |||
53465844 | 76186 | 0 | None | 131 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 441 | 8 | 4 | 3 | 4.2 | O=C(Nc1ccccc1C(=O)N[C@H](CCc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 | 10.1021/jm200438b | |||
CHEMBL1933104 | 76186 | 0 | None | 131 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 441 | 8 | 4 | 3 | 4.2 | O=C(Nc1ccccc1C(=O)N[C@H](CCc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 | 10.1021/jm200438b | |||
44265985 | 214452 | 0 | None | - | 1 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 376 | 6 | 2 | 1 | 6.0 | O=C(NCCC=C(c1ccccc1)c1ccccc1)Nc1ccc(Cl)cc1 | 10.1021/jm00084a009 | |||
CHEMBL9538 | 214452 | 0 | None | - | 1 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 376 | 6 | 2 | 1 | 6.0 | O=C(NCCC=C(c1ccccc1)c1ccccc1)Nc1ccc(Cl)cc1 | 10.1021/jm00084a009 | |||
44265913 | 213372 | 0 | None | - | 1 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 381 | 5 | 1 | 1 | 5.9 | O=C(NCC=C(c1ccccc1)c1ccccc1)c1ccc(Cl)c(Cl)c1 | 10.1021/jm00084a009 | |||
CHEMBL8893 | 213372 | 0 | None | - | 1 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 381 | 5 | 1 | 1 | 5.9 | O=C(NCC=C(c1ccccc1)c1ccccc1)c1ccc(Cl)c(Cl)c1 | 10.1021/jm00084a009 | |||
10604230 | 121990 | 0 | None | -5 | 2 | Guinea pig | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 645 | 10 | 4 | 4 | 4.8 | O=C(O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC12CC3CC(CC(C3)C1)C2 | 10.1021/jm00021a019 | |||
CHEMBL334523 | 121990 | 0 | None | -5 | 2 | Guinea pig | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 645 | 10 | 4 | 4 | 4.8 | O=C(O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC12CC3CC(CC(C3)C1)C2 | 10.1021/jm00021a019 | |||
10676196 | 126018 | 0 | None | -234 | 2 | Guinea pig | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 699 | 11 | 5 | 5 | 6.0 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC2CCCCC2)cc(C(=O)O)c1 | 10.1021/jm00021a019 | |||
CHEMBL343515 | 126018 | 0 | None | -234 | 2 | Guinea pig | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 699 | 11 | 5 | 5 | 6.0 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC2CCCCC2)cc(C(=O)O)c1 | 10.1021/jm00021a019 | |||
56673523 | 70924 | 0 | None | - | 1 | Rat | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 479 | 10 | 2 | 4 | 3.9 | CCN(CC)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(CCC(C)C)c2ccccc21 | 10.1016/j.bmc.2011.05.057 | |||
CHEMBL1808413 | 70924 | 0 | None | - | 1 | Rat | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 479 | 10 | 2 | 4 | 3.9 | CCN(CC)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(CCC(C)C)c2ccccc21 | 10.1016/j.bmc.2011.05.057 | |||
16732018 | 92243 | 0 | None | -741 | 2 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 548 | 9 | 2 | 6 | 4.9 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(OCC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
CHEMBL226729 | 92243 | 0 | None | -741 | 2 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 548 | 9 | 2 | 6 | 4.9 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(OCC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
10769001 | 119958 | 0 | None | -13803 | 2 | Rat | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 549 | 5 | 3 | 4 | 5.7 | Nc1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 | 10.1021/jm990967h | |||
CHEMBL331468 | 119958 | 0 | None | -13803 | 2 | Rat | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 549 | 5 | 3 | 4 | 5.7 | Nc1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 | 10.1021/jm990967h | |||
10390666 | 215084 | 0 | None | -17 | 2 | Guinea pig | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 485 | 7 | 3 | 3 | 5.3 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCc1ccccc1 | 10.1021/jm00072a005 | |||
CHEMBL99076 | 215084 | 0 | None | -17 | 2 | Guinea pig | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 485 | 7 | 3 | 3 | 5.3 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCc1ccccc1 | 10.1021/jm00072a005 | |||
19043358 | 11133 | 0 | None | 22 | 2 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 490 | 6 | 2 | 3 | 5.6 | CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccc(Cl)cc21 | 10.1016/0960-894X(95)00528-2 | |||
CHEMBL101125 | 11133 | 0 | None | 22 | 2 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 490 | 6 | 2 | 3 | 5.6 | CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccc(Cl)cc21 | 10.1016/0960-894X(95)00528-2 | |||
44408524 | 162484 | 0 | None | -169 | 4 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 1134 | 30 | 12 | 15 | 2.6 | CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)C(=O)O | 10.1021/jm050851n | |||
CHEMBL405192 | 162484 | 0 | None | -169 | 4 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 1134 | 30 | 12 | 15 | 2.6 | CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)C(=O)O | 10.1021/jm050851n | |||
11605694 | 175432 | 0 | None | -70 | 3 | Guinea pig | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 497 | 7 | 3 | 3 | 6.8 | Cc1ccc(NC(=O)c2[nH]c(-c3ccccc3C)nc2CCC23CC4CC(CC(C4)C2)C3)cc1C(=O)O | 10.1021/jm0490686 | |||
CHEMBL436314 | 175432 | 0 | None | -70 | 3 | Guinea pig | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 497 | 7 | 3 | 3 | 6.8 | Cc1ccc(NC(=O)c2[nH]c(-c3ccccc3C)nc2CCC23CC4CC(CC(C4)C2)C3)cc1C(=O)O | 10.1021/jm0490686 | |||
10818497 | 32624 | 0 | None | -58 | 2 | Guinea pig | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 701 | 8 | 4 | 5 | 5.9 | O=C(O)c1cc(NC(=O)[C@@H]2CCCN2C(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm00021a019 | |||
CHEMBL135344 | 32624 | 0 | None | -58 | 2 | Guinea pig | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 701 | 8 | 4 | 5 | 5.9 | O=C(O)c1cc(NC(=O)[C@@H]2CCCN2C(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm00021a019 | |||
CHEMBL3351054 | 218317 | 0 | None | -812 | 2 | Guinea pig | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1ccc2ccccc2c1)C(=O)N(C)[C@@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C | 10.1021/jm00053a022 | |||||
9983949 | 214520 | 0 | None | -23 | 2 | Guinea pig | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 513 | 9 | 3 | 3 | 5.8 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCCc1ccccc1 | 10.1021/jm00072a005 | |||
CHEMBL95793 | 214520 | 0 | None | -23 | 2 | Guinea pig | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 513 | 9 | 3 | 3 | 5.8 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCCc1ccccc1 | 10.1021/jm00072a005 | |||
52949124 | 7663 | 4 | None | -2 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
9055 | 7663 | 4 | None | -2 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
CHEMBL1269258 | 7663 | 4 | None | -2 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
DB12694 | 7663 | 4 | None | -2 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
10531553 | 123408 | 0 | None | -31 | 2 | Guinea pig | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 595 | 7 | 3 | 4 | 4.0 | O=C(O)CNC(=O)[C@@H]1CCCN1C(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC12C[C@H]3C[C@@H](C1)C[C@@H](C2)C3 | 10.1021/jm00021a019 | |||
CHEMBL336896 | 123408 | 0 | None | -31 | 2 | Guinea pig | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 595 | 7 | 3 | 4 | 4.0 | O=C(O)CNC(=O)[C@@H]1CCCN1C(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC12C[C@H]3C[C@@H](C1)C[C@@H](C2)C3 | 10.1021/jm00021a019 | |||
44346345 | 119861 | 0 | None | -43 | 2 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 523 | 5 | 2 | 4 | 5.1 | CN(C)c1cccc(NC(=O)NC2C(=O)N(c3ccccc3)c3ccccc3N(C3CC4CCC3C4)C2=O)c1 | 10.1021/jm990967h | |||
CHEMBL331262 | 119861 | 0 | None | -43 | 2 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 523 | 5 | 2 | 4 | 5.1 | CN(C)c1cccc(NC(=O)NC2C(=O)N(c3ccccc3)c3ccccc3N(C3CC4CCC3C4)C2=O)c1 | 10.1021/jm990967h | |||
10747623 | 176260 | 0 | None | -29 | 2 | Guinea pig | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 746 | 12 | 6 | 5 | 6.1 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCCc2c[nH]c3ccccc23)cc(C(=O)O)c1 | 10.1021/jm00021a019 | |||
CHEMBL443028 | 176260 | 0 | None | -29 | 2 | Guinea pig | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 746 | 12 | 6 | 5 | 6.1 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCCc2c[nH]c3ccccc23)cc(C(=O)O)c1 | 10.1021/jm00021a019 | |||
44451519 | 102532 | 0 | None | -58 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 518 | 6 | 1 | 4 | 6.1 | Cc1cccc(NC(=O)CN2C(=O)N(CC(=O)C(C)(C)C)c3ccccc3N(C3CCCCCC3)C2=O)c1 | 10.1016/j.bmc.2007.12.047 | |||
CHEMBL258486 | 102532 | 0 | None | -58 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 518 | 6 | 1 | 4 | 6.1 | Cc1cccc(NC(=O)CN2C(=O)N(CC(=O)C(C)(C)C)c3ccccc3N(C3CCCCCC3)C2=O)c1 | 10.1016/j.bmc.2007.12.047 | |||
10579091 | 21144 | 0 | None | -398 | 2 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 577 | 6 | 2 | 4 | 6.2 | CN(C)c1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 | 10.1021/jm990967h | |||
CHEMBL120021 | 21144 | 0 | None | -398 | 2 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 577 | 6 | 2 | 4 | 6.2 | CN(C)c1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 | 10.1021/jm990967h | |||
44265914 | 213458 | 0 | None | - | 1 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 363 | 5 | 1 | 1 | 5.7 | O=C(NCC=C(c1ccccc1)c1ccccc1)c1ccc2ccccc2c1 | 10.1021/jm00084a009 | |||
CHEMBL8949 | 213458 | 0 | None | - | 1 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 363 | 5 | 1 | 1 | 5.7 | O=C(NCC=C(c1ccccc1)c1ccccc1)c1ccc2ccccc2c1 | 10.1021/jm00084a009 | |||
16732162 | 148871 | 0 | None | -1862 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 584 | 8 | 2 | 6 | 6.4 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3ccc(C(=O)O)o3)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
CHEMBL388144 | 148871 | 0 | None | -1862 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 584 | 8 | 2 | 6 | 6.4 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3ccc(C(=O)O)o3)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
10004216 | 11515 | 0 | None | -11 | 2 | Rat | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 456 | 6 | 2 | 3 | 4.9 | CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21 | 10.1021/jm990967h | |||
CHEMBL103750 | 11515 | 0 | None | -11 | 2 | Rat | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 456 | 6 | 2 | 3 | 4.9 | CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21 | 10.1021/jm990967h | |||
44346255 | 123659 | 0 | None | -30 | 2 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 564 | 6 | 2 | 7 | 6.7 | CC(C)(C1CCCC1)N1C(=O)C(NC(=O)Nc2cccc(C3N=NN=N3)c2)C(=O)N(c2ccccc2)c2ccccc21 | 10.1021/jm990967h | |||
CHEMBL338278 | 123659 | 0 | None | -30 | 2 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 564 | 6 | 2 | 7 | 6.7 | CC(C)(C1CCCC1)N1C(=O)C(NC(=O)Nc2cccc(C3N=NN=N3)c2)C(=O)N(c2ccccc2)c2ccccc21 | 10.1021/jm990967h | |||
19700643 | 70793 | 0 | None | - | 1 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 505 | 9 | 2 | 4 | 4.5 | CCN(CC)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(CC2CCCCC2)c2ccccc21 | 10.1016/j.bmc.2011.05.057 | |||
CHEMBL1807152 | 70793 | 0 | None | - | 1 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 505 | 9 | 2 | 4 | 4.5 | CCN(CC)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(CC2CCCCC2)c2ccccc21 | 10.1016/j.bmc.2011.05.057 | |||
135423404 | 92287 | 0 | None | -4365 | 4 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 570 | 8 | 2 | 7 | 5.0 | O=C(CN1N=C(C2CCCCC2)c2ccccc2N(CC(=O)C2CCCC2)C1=O)Nc1cccc(-c2noc(=O)[nH]2)c1 | 10.1021/jm070139l | |||
CHEMBL227276 | 92287 | 0 | None | -4365 | 4 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 570 | 8 | 2 | 7 | 5.0 | O=C(CN1N=C(C2CCCCC2)c2ccccc2N(CC(=O)C2CCCC2)C1=O)Nc1cccc(-c2noc(=O)[nH]2)c1 | 10.1021/jm070139l | |||
5311201 | 214174 | 35 | None | -2570 | 6 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00048a001 | |||
CHEMBL9387 | 214174 | 35 | None | -2570 | 6 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00048a001 | |||
115208 | 10590 | 28 | None | -91 | 4 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 393 | 4 | 1 | 4 | 4.0 | O=C(c1ccsc1)NCC1CN=C(c2c(N1C)cccc2)c1ccccc1F | 10.1021/jm950423p | |||
1667 | 10590 | 28 | None | -91 | 4 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 393 | 4 | 1 | 4 | 4.0 | O=C(c1ccsc1)NCC1CN=C(c2c(N1C)cccc2)c1ccccc1F | 10.1021/jm950423p | |||
CHEMBL169703 | 10590 | 28 | None | -91 | 4 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 393 | 4 | 1 | 4 | 4.0 | O=C(c1ccsc1)NCC1CN=C(c2c(N1C)cccc2)c1ccccc1F | 10.1021/jm950423p | |||
44346126 | 22038 | 0 | None | -27 | 2 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 514 | 4 | 2 | 3 | 5.7 | O=C(Nc1cccc(Cl)c1)NC1C(=O)N(c2ccccc2)c2ccccc2N(C2CC3CCC2C3)C1=O | 10.1021/jm990967h | |||
CHEMBL121267 | 22038 | 0 | None | -27 | 2 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 514 | 4 | 2 | 3 | 5.7 | O=C(Nc1cccc(Cl)c1)NC1C(=O)N(c2ccccc2)c2ccccc2N(C2CC3CCC2C3)C1=O | 10.1021/jm990967h | |||
10792618 | 171132 | 0 | None | -70 | 2 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 543 | 7 | 2 | 4 | 5.7 | CN(C)c1cccc(NC(=O)NC2C(=O)N(CCC3CCCC3)c3ccccc3N(c3ccccc3F)C2=O)c1 | 10.1021/jm990967h | |||
CHEMBL421271 | 171132 | 0 | None | -70 | 2 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 543 | 7 | 2 | 4 | 5.7 | CN(C)c1cccc(NC(=O)NC2C(=O)N(CCC3CCCC3)c3ccccc3N(c3ccccc3F)C2=O)c1 | 10.1021/jm990967h | |||
44265917 | 214393 | 0 | None | - | 1 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 364 | 5 | 1 | 2 | 5.1 | O=C(NCC=C(c1ccccc1)c1ccccc1)c1ccc2ccccc2n1 | 10.1021/jm00084a009 | |||
CHEMBL9510 | 214393 | 0 | None | - | 1 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 364 | 5 | 1 | 2 | 5.1 | O=C(NCC=C(c1ccccc1)c1ccccc1)c1ccc2ccccc2n1 | 10.1021/jm00084a009 | |||
9850043 | 119650 | 2 | None | -446 | 3 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 534 | 5 | 2 | 3 | 6.1 | O=C(Nc1ccccc1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O | 10.1021/jm990967h | |||
CHEMBL330977 | 119650 | 2 | None | -446 | 3 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 534 | 5 | 2 | 3 | 6.1 | O=C(Nc1ccccc1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O | 10.1021/jm990967h | |||
10603576 | 21284 | 0 | None | -19 | 2 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 594 | 8 | 2 | 7 | 5.6 | CC(C)Cn1nnc(-c2cccc(NC(=O)NC3C(=O)N(CCC(C)(C)C)c4ccccc4N(c4ccccc4)C3=O)c2)n1 | 10.1021/jm990967h | |||
CHEMBL120168 | 21284 | 0 | None | -19 | 2 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 594 | 8 | 2 | 7 | 5.6 | CC(C)Cn1nnc(-c2cccc(NC(=O)NC3C(=O)N(CCC(C)(C)C)c4ccccc4N(c4ccccc4)C3=O)c2)n1 | 10.1021/jm990967h | |||
10747599 | 32632 | 0 | None | -46 | 2 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 743 | 11 | 5 | 5 | 6.7 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCc2cccc3ccccc23)cc(C(=O)O)c1 | 10.1021/jm00021a019 | |||
CHEMBL135350 | 32632 | 0 | None | -46 | 2 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 743 | 11 | 5 | 5 | 6.7 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCc2cccc3ccccc23)cc(C(=O)O)c1 | 10.1021/jm00021a019 | |||
13605417 | 214347 | 4 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 458 | 14 | 2 | 3 | 5.2 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1ccc(Cl)c(Cl)c1 | 10.1021/jm00084a009 | |||
CHEMBL9485 | 214347 | 4 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 458 | 14 | 2 | 3 | 5.2 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1ccc(Cl)c(Cl)c1 | 10.1021/jm00084a009 | |||
53465844 | 76186 | 0 | None | 131 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 441 | 8 | 4 | 3 | 4.2 | O=C(Nc1ccccc1C(=O)N[C@H](CCc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 | 10.1021/jm200438b | |||
CHEMBL1933104 | 76186 | 0 | None | 131 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 441 | 8 | 4 | 3 | 4.2 | O=C(Nc1ccccc1C(=O)N[C@H](CCc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 | 10.1021/jm200438b | |||
53465844 | 76186 | 0 | None | 131 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 441 | 8 | 4 | 3 | 4.2 | O=C(Nc1ccccc1C(=O)N[C@H](CCc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 | 10.1021/jm200438b | |||
CHEMBL1933104 | 76186 | 0 | None | 131 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 441 | 8 | 4 | 3 | 4.2 | O=C(Nc1ccccc1C(=O)N[C@H](CCc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 | 10.1021/jm200438b | |||
10507109 | 116004 | 0 | None | -1 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 561 | 7 | 2 | 4 | 5.3 | CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1016/j.bmc.2007.12.047 | |||
CHEMBL321761 | 116004 | 0 | None | -1 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 561 | 7 | 2 | 4 | 5.3 | CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1016/j.bmc.2007.12.047 | |||
11512151 | 203565 | 0 | None | 158 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 534 | 7 | 2 | 6 | 5.5 | CC(C)(CNC(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2009.09.064 | |||
CHEMBL565511 | 203565 | 0 | None | 158 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 534 | 7 | 2 | 6 | 5.5 | CC(C)(CNC(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2009.09.064 | |||
44328951 | 171376 | 0 | None | -3 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 533 | 5 | 2 | 4 | 3.8 | O=C(Nc1ccc(F)cc1)NC1C(=O)N(CC(=O)N2CCCC2)c2ccccc2N(c2ccccc2F)C1=O | 10.1016/S0960-894X(96)00613-0 | |||
CHEMBL421575 | 171376 | 0 | None | -3 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 533 | 5 | 2 | 4 | 3.8 | O=C(Nc1ccc(F)cc1)NC1C(=O)N(CC(=O)N2CCCC2)c2ccccc2N(c2ccccc2F)C1=O | 10.1016/S0960-894X(96)00613-0 | |||
11556194 | 204338 | 0 | None | -3 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 598 | 8 | 3 | 7 | 5.4 | C[C@H](c1ccc(Cl)c(Cl)c1)[C@H](NC(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)C(=O)O | 10.1016/j.bmcl.2009.09.064 | |||
CHEMBL570297 | 204338 | 0 | None | -3 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 598 | 8 | 3 | 7 | 5.4 | C[C@H](c1ccc(Cl)c(Cl)c1)[C@H](NC(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)C(=O)O | 10.1016/j.bmcl.2009.09.064 | |||
9832467 | 151071 | 0 | None | -602 | 5 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 477 | 7 | 3 | 4 | 5.9 | O=C(O)c1cccc(NC(=O)c2nc(C3CCCCC3)[nH]c2COC23CC4CC(CC(C4)C2)C3)c1 | 10.1021/jm070880t | |||
CHEMBL390519 | 151071 | 0 | None | -602 | 5 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 477 | 7 | 3 | 4 | 5.9 | O=C(O)c1cccc(NC(=O)c2nc(C3CCCCC3)[nH]c2COC23CC4CC(CC(C4)C2)C3)c1 | 10.1021/jm070880t | |||
11555110 | 18738 | 0 | None | -5 | 2 | Guinea pig | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 500 | 7 | 5 | 4 | 5.7 | O=C(O)c1cc(NC(=O)c2[nH]c(-c3ccc4[nH]ccc4c3)nc2CC2CCCCCC2)cc(C(=O)O)c1 | 10.1021/jm049069y | |||
CHEMBL1182962 | 18738 | 0 | None | -5 | 2 | Guinea pig | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 500 | 7 | 5 | 4 | 5.7 | O=C(O)c1cc(NC(=O)c2[nH]c(-c3ccc4[nH]ccc4c3)nc2CC2CCCCCC2)cc(C(=O)O)c1 | 10.1021/jm049069y | |||
CHEMBL2067954 | 18738 | 0 | None | -5 | 2 | Guinea pig | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 500 | 7 | 5 | 4 | 5.7 | O=C(O)c1cc(NC(=O)c2[nH]c(-c3ccc4[nH]ccc4c3)nc2CC2CCCCCC2)cc(C(=O)O)c1 | 10.1021/jm049069y | |||
44403999 | 19056 | 0 | None | -12 | 2 | Guinea pig | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 619 | 10 | 5 | 5 | 5.2 | O=C(O)c1cccc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)c1 | 10.1021/jm049069y | |||
CHEMBL1184841 | 19056 | 0 | None | -12 | 2 | Guinea pig | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 619 | 10 | 5 | 5 | 5.2 | O=C(O)c1cccc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)c1 | 10.1021/jm049069y | |||
CHEMBL2067962 | 19056 | 0 | None | -12 | 2 | Guinea pig | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 619 | 10 | 5 | 5 | 5.2 | O=C(O)c1cccc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)c1 | 10.1021/jm049069y | |||
11605951 | 19058 | 0 | None | -25 | 2 | Guinea pig | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 512 | 8 | 4 | 3 | 6.5 | O=C(O)c1cc(NC(=O)c2cc(-c3ccccc3)[nH]c2CCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm049069y | |||
CHEMBL1184851 | 19058 | 0 | None | -25 | 2 | Guinea pig | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 512 | 8 | 4 | 3 | 6.5 | O=C(O)c1cc(NC(=O)c2cc(-c3ccccc3)[nH]c2CCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm049069y | |||
CHEMBL2067961 | 19058 | 0 | None | -25 | 2 | Guinea pig | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 512 | 8 | 4 | 3 | 6.5 | O=C(O)c1cc(NC(=O)c2cc(-c3ccccc3)[nH]c2CCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm049069y | |||
73356071 | 96161 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 896 | 26 | 9 | 9 | 2.1 | CCCC[C@H](NC(=O)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm990252e | |||
CHEMBL2369818 | 96161 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 896 | 26 | 9 | 9 | 2.1 | CCCC[C@H](NC(=O)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm990252e | |||
CHEMBL382349 | 219081 | 0 | None | -3235 | 4 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm050921q | |||||
56663145 | 70918 | 0 | None | - | 1 | Rat | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 541 | 8 | 2 | 5 | 3.9 | Cc1cccc(Cl)c1NC(=O)NC1C(=O)N(CCC(C)C)c2ccccc2N(CCN2CCOCC2)C1=O | 10.1016/j.bmc.2011.05.057 | |||
CHEMBL1808407 | 70918 | 0 | None | - | 1 | Rat | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 541 | 8 | 2 | 5 | 3.9 | Cc1cccc(Cl)c1NC(=O)NC1C(=O)N(CCC(C)C)c2ccccc2N(CCN2CCOCC2)C1=O | 10.1016/j.bmc.2011.05.057 | |||
19700618 | 70919 | 0 | None | - | 1 | Rat | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 523 | 9 | 2 | 6 | 2.9 | COc1ccc(NC(=O)NC2C(=O)N(CCC(C)C)c3ccccc3N(CCN3CCOCC3)C2=O)cc1 | 10.1016/j.bmc.2011.05.057 | |||
CHEMBL1808408 | 70919 | 0 | None | - | 1 | Rat | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 523 | 9 | 2 | 6 | 2.9 | COc1ccc(NC(=O)NC2C(=O)N(CCC(C)C)c3ccccc3N(CCN3CCOCC3)C2=O)cc1 | 10.1016/j.bmc.2011.05.057 | |||
118719287 | 122262 | 0 | None | -6 | 2 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 727 | 17 | 4 | 7 | 4.8 | CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1cccc2ccccc12)N(C)C)C(=O)N(C)[C@@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C | 10.1021/jm00053a022 | |||
CHEMBL3351059 | 122262 | 0 | None | -6 | 2 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 727 | 17 | 4 | 7 | 4.8 | CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1cccc2ccccc12)N(C)C)C(=O)N(C)[C@@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C | 10.1021/jm00053a022 | |||
CHEMBL3142842 | 217914 | 0 | None | -2 | 2 | Guinea pig | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | None | None | None | CC(C)(C)OC(=O)NCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00174a016 | |||||
53465844 | 76186 | 0 | None | 131 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 441 | 8 | 4 | 3 | 4.2 | O=C(Nc1ccccc1C(=O)N[C@H](CCc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 | 10.1021/jm200438b | |||
CHEMBL1933104 | 76186 | 0 | None | 131 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 441 | 8 | 4 | 3 | 4.2 | O=C(Nc1ccccc1C(=O)N[C@H](CCc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 | 10.1021/jm200438b | |||
11518283 | 172939 | 0 | None | -74 | 3 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 461 | 7 | 3 | 3 | 6.2 | O=C(O)c1cccc(NC(=O)c2[nH]c(C3CCCC3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 | 10.1021/jm0490686 | |||
CHEMBL426290 | 172939 | 0 | None | -74 | 3 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 461 | 7 | 3 | 3 | 6.2 | O=C(O)c1cccc(NC(=O)c2[nH]c(C3CCCC3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 | 10.1021/jm0490686 | |||
10482868 | 114181 | 0 | None | -37 | 5 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 557 | 10 | 3 | 4 | 5.2 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccc1)CC(=O)O | 10.1021/jm00072a005 | |||
CHEMBL317999 | 114181 | 0 | None | -37 | 5 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 557 | 10 | 3 | 4 | 5.2 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccc1)CC(=O)O | 10.1021/jm00072a005 | |||
11613212 | 78876 | 0 | None | -39 | 3 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 513 | 7 | 3 | 4 | 6.4 | Cc1cc(C)c(-c2nc(C(=O)Nc3cccc(C(=O)O)c3)c(COC34CC5CC(CC(C5)C3)C4)[nH]2)c(C)c1 | 10.1021/jm0490686 | |||
CHEMBL197780 | 78876 | 0 | None | -39 | 3 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 513 | 7 | 3 | 4 | 6.4 | Cc1cc(C)c(-c2nc(C(=O)Nc3cccc(C(=O)O)c3)c(COC34CC5CC(CC(C5)C3)C4)[nH]2)c(C)c1 | 10.1021/jm0490686 | |||
56666597 | 70917 | 0 | None | - | 1 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 585 | 8 | 2 | 5 | 4.0 | Cc1cc(Br)ccc1NC(=O)NC1C(=O)N(CCC(C)C)c2ccccc2N(CCN2CCOCC2)C1=O | 10.1016/j.bmc.2011.05.057 | |||
CHEMBL1808405 | 70917 | 0 | None | - | 1 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 585 | 8 | 2 | 5 | 4.0 | Cc1cc(Br)ccc1NC(=O)NC1C(=O)N(CCC(C)C)c2ccccc2N(CCN2CCOCC2)C1=O | 10.1016/j.bmc.2011.05.057 | |||
118719284 | 122260 | 0 | None | -72 | 2 | Guinea pig | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 739 | 15 | 5 | 7 | 4.9 | CN(C)[C@@H](Cc1cccc2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C)C1CCCCC1 | 10.1021/jm00053a022 | |||
CHEMBL3351056 | 122260 | 0 | None | -72 | 2 | Guinea pig | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 739 | 15 | 5 | 7 | 4.9 | CN(C)[C@@H](Cc1cccc2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C)C1CCCCC1 | 10.1021/jm00053a022 | |||
16733185 | 148870 | 0 | None | -346 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 594 | 8 | 2 | 5 | 6.8 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3cccc(C(=O)O)c3)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
CHEMBL388143 | 148870 | 0 | None | -346 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 594 | 8 | 2 | 5 | 6.8 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3cccc(C(=O)O)c3)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
16732164 | 150081 | 0 | None | -1862 | 4 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 571 | 8 | 2 | 6 | 5.5 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2ccc3ccn(CC(=O)O)c3c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
CHEMBL389711 | 150081 | 0 | None | -1862 | 4 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 571 | 8 | 2 | 6 | 5.5 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2ccc3ccn(CC(=O)O)c3c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
10623068 | 119618 | 0 | None | -89 | 2 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 442 | 6 | 2 | 3 | 4.7 | CCCCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21 | 10.1021/jm990967h | |||
CHEMBL330854 | 119618 | 0 | None | -89 | 2 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 442 | 6 | 2 | 3 | 4.7 | CCCCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21 | 10.1021/jm990967h | |||
CHEMBL1172246 | 215360 | 0 | None | 1 | 4 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CC(=O)NCCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc2ccccc2)C(N)=O)NC(=O)[C@H](Cc2cc3ccccc3[nH]2)NC1=O | 10.1016/j.bmcl.2010.05.078 | |||||
44408483 | 175708 | 0 | None | -165 | 4 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 1212 | 31 | 12 | 15 | 3.7 | CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@H](Cc1cn(C(=O)OC2C3CC4CC(C3)CC2C4)c2ccccc12)C(=O)O | 10.1021/jm050851n | |||
CHEMBL438739 | 175708 | 0 | None | -165 | 4 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 1212 | 31 | 12 | 15 | 3.7 | CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@H](Cc1cn(C(=O)OC2C3CC4CC(C3)CC2C4)c2ccccc12)C(=O)O | 10.1021/jm050851n | |||
11511706 | 79036 | 0 | None | -12 | 3 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 501 | 7 | 3 | 3 | 6.6 | Cc1ccccc1-c1nc(C(=O)Nc2ccc(F)c(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 | 10.1021/jm0490686 | |||
CHEMBL198225 | 79036 | 0 | None | -12 | 3 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 501 | 7 | 3 | 3 | 6.6 | Cc1ccccc1-c1nc(C(=O)Nc2ccc(F)c(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 | 10.1021/jm0490686 | |||
11571142 | 142584 | 0 | None | -346 | 3 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 489 | 7 | 3 | 3 | 6.7 | CC1(c2nc(C(=O)Nc3cccc(C(=O)O)c3)c(CCC34CC5CC(CC(C5)C3)C4)[nH]2)CCCCC1 | 10.1021/jm0490686 | |||
CHEMBL373050 | 142584 | 0 | None | -346 | 3 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 489 | 7 | 3 | 3 | 6.7 | CC1(c2nc(C(=O)Nc3cccc(C(=O)O)c3)c(CCC34CC5CC(CC(C5)C3)C4)[nH]2)CCCCC1 | 10.1021/jm0490686 | |||
9832467 | 151071 | 0 | None | -602 | 5 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 477 | 7 | 3 | 4 | 5.9 | O=C(O)c1cccc(NC(=O)c2nc(C3CCCCC3)[nH]c2COC23CC4CC(CC(C4)C2)C3)c1 | 10.1021/jm0490686 | |||
CHEMBL390519 | 151071 | 0 | None | -602 | 5 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 477 | 7 | 3 | 4 | 5.9 | O=C(O)c1cccc(NC(=O)c2nc(C3CCCCC3)[nH]c2COC23CC4CC(CC(C4)C2)C3)c1 | 10.1021/jm0490686 | |||
10256780 | 119456 | 0 | None | -234 | 2 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 540 | 5 | 2 | 3 | 6.1 | O=C(Nc1ccccc1)NC1C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc2N(C2CCCCC2)C1=O | 10.1016/S0960-894X(96)00544-6 | |||
CHEMBL330409 | 119456 | 0 | None | -234 | 2 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 540 | 5 | 2 | 3 | 6.1 | O=C(Nc1ccccc1)NC1C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc2N(C2CCCCC2)C1=O | 10.1016/S0960-894X(96)00544-6 | |||
CHEMBL262172 | 217307 | 0 | None | -26302 | 4 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm050921q | |||||
10626665 | 17033 | 0 | None | - | 1 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 559 | 7 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@H]12 | 10.1021/jm9703247 | |||
CHEMBL116127 | 17033 | 0 | None | - | 1 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 559 | 7 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@H]12 | 10.1021/jm9703247 | |||
11540160 | 78223 | 0 | None | -117 | 3 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 475 | 7 | 3 | 3 | 6.6 | O=C(O)c1cccc(NC(=O)c2[nH]c(C3CCCCC3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 | 10.1021/jm0490686 | |||
CHEMBL196133 | 78223 | 0 | None | -117 | 3 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 475 | 7 | 3 | 3 | 6.6 | O=C(O)c1cccc(NC(=O)c2[nH]c(C3CCCCC3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 | 10.1021/jm0490686 | |||
16732443 | 92272 | 0 | None | -1202 | 2 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 532 | 7 | 2 | 5 | 5.6 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
CHEMBL227147 | 92272 | 0 | None | -1202 | 2 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 532 | 7 | 2 | 5 | 5.6 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
135610887 | 92217 | 0 | None | -2951 | 4 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 558 | 7 | 2 | 7 | 4.8 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nc(=O)o[nH]3)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
CHEMBL226583 | 92217 | 0 | None | -2951 | 4 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 558 | 7 | 2 | 7 | 4.8 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nc(=O)o[nH]3)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
11656338 | 82720 | 0 | None | -389 | 3 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 504 | 7 | 2 | 5 | 5.0 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CO)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm051219x | |||
CHEMBL205198 | 82720 | 0 | None | -389 | 3 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 504 | 7 | 2 | 5 | 5.0 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CO)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm051219x | |||
10071178 | 81270 | 2 | None | 501 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 427 | 7 | 4 | 3 | 3.8 | O=C(Nc1ccccc1C(=O)NC(Cc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 | 10.1021/jm200438b | |||
CHEMBL202861 | 81270 | 2 | None | 501 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 427 | 7 | 4 | 3 | 3.8 | O=C(Nc1ccccc1C(=O)NC(Cc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 | 10.1021/jm200438b | |||
10367509 | 114219 | 0 | None | -14 | 2 | Guinea pig | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 471 | 6 | 3 | 3 | 5.7 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)Nc1ccccc1 | 10.1021/jm00072a005 | |||
CHEMBL318238 | 114219 | 0 | None | -14 | 2 | Guinea pig | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 471 | 6 | 3 | 3 | 5.7 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)Nc1ccccc1 | 10.1021/jm00072a005 | |||
44331505 | 11125 | 0 | None | -25 | 2 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 450 | 8 | 2 | 3 | 4.6 | CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(CCC(C)C)c2ccccc21 | 10.1016/S0960-894X(96)00544-6 | |||
CHEMBL101063 | 11125 | 0 | None | -25 | 2 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 450 | 8 | 2 | 3 | 4.6 | CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(CCC(C)C)c2ccccc21 | 10.1016/S0960-894X(96)00544-6 | |||
10794691 | 123840 | 0 | None | 1 | 2 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 684 | 10 | 5 | 4 | 5.3 | O=C(O)CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC12CC3CC(CC(C3)C1)C2 | 10.1021/jm00021a019 | |||
CHEMBL339177 | 123840 | 0 | None | 1 | 2 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 684 | 10 | 5 | 4 | 5.3 | O=C(O)CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC12CC3CC(CC(C3)C1)C2 | 10.1021/jm00021a019 | |||
11679213 | 140321 | 0 | None | -61 | 3 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 497 | 7 | 3 | 3 | 6.8 | Cc1ccc(-c2nc(C(=O)Nc3cccc(C(=O)O)c3)c(CCC34CC5CC(CC(C5)C3)C4)[nH]2)c(C)c1 | 10.1021/jm0490686 | |||
CHEMBL370882 | 140321 | 0 | None | -61 | 3 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 497 | 7 | 3 | 3 | 6.8 | Cc1ccc(-c2nc(C(=O)Nc3cccc(C(=O)O)c3)c(CCC34CC5CC(CC(C5)C3)C4)[nH]2)c(C)c1 | 10.1021/jm0490686 | |||
44451522 | 165093 | 0 | None | -26 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 531 | 6 | 1 | 4 | 5.1 | Cc1cccc(NC(=O)CN2C(=O)N(CC(=O)N3CCCC3)c3ccccc3N(C3CCCCCC3)C2=O)c1 | 10.1016/j.bmc.2007.12.047 | |||
CHEMBL408915 | 165093 | 0 | None | -26 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 531 | 6 | 1 | 4 | 5.1 | Cc1cccc(NC(=O)CN2C(=O)N(CC(=O)N3CCCC3)c3ccccc3N(C3CCCCCC3)C2=O)c1 | 10.1016/j.bmc.2007.12.047 | |||
CHEMBL1206334 | 215385 | 0 | None | -1023 | 2 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@@H](N)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/S0960-894X(00)80678-2 | |||||
CHEMBL262894 | 215385 | 0 | None | -1023 | 2 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@@H](N)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/S0960-894X(00)80678-2 | |||||
11541048 | 203754 | 0 | None | 7 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 530 | 7 | 2 | 6 | 4.8 | C[C@H](CNC(=O)c1ccc(Br)cc1NS(=O)(=O)c1cccc2nsnc12)c1ccccc1 | 10.1016/j.bmcl.2009.09.064 | |||
CHEMBL566604 | 203754 | 0 | None | 7 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 530 | 7 | 2 | 6 | 4.8 | C[C@H](CNC(=O)c1ccc(Br)cc1NS(=O)(=O)c1cccc2nsnc12)c1ccccc1 | 10.1016/j.bmcl.2009.09.064 | |||
44444934 | 161725 | 0 | None | - | 1 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 749 | 16 | 6 | 7 | 4.8 | COc1ccc(CCNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm070880t | |||
CHEMBL401098 | 161725 | 0 | None | - | 1 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 749 | 16 | 6 | 7 | 4.8 | COc1ccc(CCNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm070880t | |||
11801315 | 121552 | 0 | None | -50 | 2 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 577 | 6 | 2 | 4 | 6.0 | CN(C)c1cccc(NC(=O)NC2C(=O)N(CC3[C@H]4C[C@@H]5C[C@@H](C[C@H]3C5)C4)c3ccccc3N(c3ccccc3)C2=O)c1 | 10.1021/jm990967h | |||
CHEMBL333930 | 121552 | 0 | None | -50 | 2 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 577 | 6 | 2 | 4 | 6.0 | CN(C)c1cccc(NC(=O)NC2C(=O)N(CC3[C@H]4C[C@@H]5C[C@@H](C[C@H]3C5)C4)c3ccccc3N(c3ccccc3)C2=O)c1 | 10.1021/jm990967h | |||
108187 | 7713 | 37 | None | -4265 | 5 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1021/jm070880t | |||
873 | 7713 | 37 | None | -4265 | 5 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1021/jm070880t | |||
CHEMBL2062154 | 7713 | 37 | None | -4265 | 5 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1021/jm070880t | |||
CHEMBL287735 | 7713 | 37 | None | -4265 | 5 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1021/jm070880t | |||
10698427 | 21326 | 0 | None | -645 | 2 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 578 | 6 | 3 | 4 | 5.8 | O=C(Nc1cccc(C(=O)O)c1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O | 10.1021/jm990967h | |||
CHEMBL120363 | 21326 | 0 | None | -645 | 2 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 578 | 6 | 3 | 4 | 5.8 | O=C(Nc1cccc(C(=O)O)c1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O | 10.1021/jm990967h | |||
10555899 | 120150 | 0 | None | -2344 | 2 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 623 | 8 | 5 | 6 | 5.2 | CC(O)C(O)Nc1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 | 10.1021/jm990967h | |||
CHEMBL331763 | 120150 | 0 | None | -2344 | 2 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 623 | 8 | 5 | 6 | 5.2 | CC(O)C(O)Nc1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 | 10.1021/jm990967h | |||
CHEMBL3351062 | 218322 | 0 | None | -173 | 2 | Guinea pig | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1cccc2ccccc12)C(=O)N(C)[C@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C | 10.1021/jm00053a022 | |||||
11535277 | 19051 | 0 | None | -10 | 2 | Guinea pig | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 513 | 8 | 4 | 4 | 5.9 | O=C(O)c1cc(NC(=O)c2[nH]c(-c3ccccc3)nc2CCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm049069y | |||
CHEMBL1184817 | 19051 | 0 | None | -10 | 2 | Guinea pig | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 513 | 8 | 4 | 4 | 5.9 | O=C(O)c1cc(NC(=O)c2[nH]c(-c3ccccc3)nc2CCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm049069y | |||
CHEMBL2067964 | 19051 | 0 | None | -10 | 2 | Guinea pig | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 513 | 8 | 4 | 4 | 5.9 | O=C(O)c1cc(NC(=O)c2[nH]c(-c3ccccc3)nc2CCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm049069y | |||
10457639 | 114489 | 0 | None | - | 1 | Guinea pig | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 474 | 8 | 4 | 2 | 5.3 | CC(Cc1c[nH]c2ccccc12)(NC(=O)Nc1ccc(Cl)cc1)C(=O)NCCc1ccccc1 | 10.1021/jm00072a005 | |||
CHEMBL319096 | 114489 | 0 | None | - | 1 | Guinea pig | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 474 | 8 | 4 | 2 | 5.3 | CC(Cc1c[nH]c2ccccc12)(NC(=O)Nc1ccc(Cl)cc1)C(=O)NCCc1ccccc1 | 10.1021/jm00072a005 | |||
16732911 | 149994 | 0 | None | -999 | 4 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 564 | 9 | 2 | 6 | 5.6 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(SCC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
CHEMBL389639 | 149994 | 0 | None | -999 | 4 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 564 | 9 | 2 | 6 | 5.6 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(SCC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
16732017 | 92242 | 0 | None | -6025 | 2 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 561 | 9 | 2 | 6 | 5.0 | CN(CC(=O)O)c1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1021/jm070139l | |||
CHEMBL226726 | 92242 | 0 | None | -6025 | 2 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 561 | 9 | 2 | 6 | 5.0 | CN(CC(=O)O)c1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1021/jm070139l | |||
16732020 | 92285 | 0 | None | -3311 | 4 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 571 | 8 | 2 | 8 | 4.7 | CN(c1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1)c1nn[nH]n1 | 10.1021/jm070139l | |||
CHEMBL227254 | 92285 | 0 | None | -3311 | 4 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 571 | 8 | 2 | 8 | 4.7 | CN(c1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1)c1nn[nH]n1 | 10.1021/jm070139l | |||
CHEMBL383458 | 219092 | 0 | None | -10 | 4 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm050921q | |||||
44331468 | 11059 | 0 | None | -16 | 2 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 470 | 7 | 2 | 3 | 4.8 | CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(Cc2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00544-6 | |||
CHEMBL100685 | 11059 | 0 | None | -16 | 2 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 470 | 7 | 2 | 3 | 4.8 | CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(Cc2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00544-6 | |||
CHEMBL2370441 | 216630 | 0 | None | -2 | 2 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00174a016 | |||||
11542079 | 78497 | 0 | None | -11 | 3 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 483 | 7 | 3 | 3 | 6.5 | Cc1ccccc1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 | 10.1021/jm0490686 | |||
CHEMBL196580 | 78497 | 0 | None | -11 | 3 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 483 | 7 | 3 | 3 | 6.5 | Cc1ccccc1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 | 10.1021/jm0490686 | |||
11685703 | 78695 | 0 | None | -25 | 3 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 391 | 7 | 3 | 3 | 4.9 | Cc1ccccc1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC(C)C)[nH]1 | 10.1021/jm0490686 | |||
CHEMBL197205 | 78695 | 0 | None | -25 | 3 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 391 | 7 | 3 | 3 | 4.9 | Cc1ccccc1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC(C)C)[nH]1 | 10.1021/jm0490686 | |||
16733307 | 175601 | 0 | None | -1819 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 585 | 8 | 2 | 7 | 5.8 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nc(C(=O)O)co3)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
CHEMBL437736 | 175601 | 0 | None | -1819 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 585 | 8 | 2 | 7 | 5.8 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nc(C(=O)O)co3)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
10697783 | 124411 | 0 | None | -141 | 2 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 543 | 7 | 2 | 4 | 5.7 | CN(C)c1ccc(NC(=O)NC2C(=O)N(CCC3CCCC3)c3ccccc3N(c3ccccc3F)C2=O)cc1 | 10.1021/jm990967h | |||
CHEMBL340107 | 124411 | 0 | None | -141 | 2 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 543 | 7 | 2 | 4 | 5.7 | CN(C)c1ccc(NC(=O)NC2C(=O)N(CCC3CCCC3)c3ccccc3N(c3ccccc3F)C2=O)cc1 | 10.1021/jm990967h | |||
56673429 | 70705 | 0 | None | - | 1 | Rat | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 537 | 9 | 2 | 6 | 3.3 | COc1ccc(NC(=O)NC2C(=O)N(CCC(C)C)c3ccccc3N(CCN3CCOCC3)C2=O)c(C)c1 | 10.1016/j.bmc.2011.05.057 | |||
CHEMBL1806517 | 70705 | 0 | None | - | 1 | Rat | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 537 | 9 | 2 | 6 | 3.3 | COc1ccc(NC(=O)NC2C(=O)N(CCC(C)C)c3ccccc3N(CCN3CCOCC3)C2=O)c(C)c1 | 10.1016/j.bmc.2011.05.057 | |||
19700612 | 70911 | 0 | None | - | 1 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 493 | 8 | 2 | 5 | 2.9 | CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(CCN2CCOCC2)c2ccccc21 | 10.1016/j.bmc.2011.05.057 | |||
CHEMBL1808398 | 70911 | 0 | None | - | 1 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 493 | 8 | 2 | 5 | 2.9 | CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(CCN2CCOCC2)c2ccccc21 | 10.1016/j.bmc.2011.05.057 | |||
16732594 | 21139 | 0 | None | -2511 | 2 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 572 | 8 | 2 | 7 | 4.9 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc3c2cnn3CC(=O)O)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
CHEMBL1161950 | 21139 | 0 | None | -2511 | 2 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 572 | 8 | 2 | 7 | 4.9 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc3c2cnn3CC(=O)O)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
CHEMBL1200187 | 21139 | 0 | None | -2511 | 2 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 572 | 8 | 2 | 7 | 4.9 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc3c2cnn3CC(=O)O)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
44303372 | 209456 | 0 | None | - | 1 | Mouse | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 317 | 7 | 2 | 3 | 2.0 | CCCCNC(=O)[C@@H]1Cc2ccccc2N1C(=O)CC(N)CC | 10.1021/jm980521l | |||
CHEMBL61498 | 209456 | 0 | None | - | 1 | Mouse | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 317 | 7 | 2 | 3 | 2.0 | CCCCNC(=O)[C@@H]1Cc2ccccc2N1C(=O)CC(N)CC | 10.1021/jm980521l | |||
10768190 | 119608 | 0 | None | -15 | 2 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 516 | 6 | 2 | 4 | 6.0 | CSc1cccc(NC(=O)NC2C(=O)N(CCC(C)(C)C)c3ccccc3N(c3ccccc3)C2=O)c1 | 10.1021/jm990967h | |||
CHEMBL330773 | 119608 | 0 | None | -15 | 2 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 516 | 6 | 2 | 4 | 6.0 | CSc1cccc(NC(=O)NC2C(=O)N(CCC(C)(C)C)c3ccccc3N(c3ccccc3)C2=O)c1 | 10.1021/jm990967h | |||
53465844 | 76186 | 0 | None | 131 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 441 | 8 | 4 | 3 | 4.2 | O=C(Nc1ccccc1C(=O)N[C@H](CCc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 | 10.1021/jm200438b | |||
CHEMBL1933104 | 76186 | 0 | None | 131 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 441 | 8 | 4 | 3 | 4.2 | O=C(Nc1ccccc1C(=O)N[C@H](CCc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 | 10.1021/jm200438b | |||
10460632 | 215109 | 0 | None | 43 | 2 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 568 | 10 | 2 | 4 | 5.8 | CC(Cc1ccc2ccccc2c1)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccc1)CC(=O)O | 10.1021/jm00072a005 | |||
CHEMBL99252 | 215109 | 0 | None | 43 | 2 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 568 | 10 | 2 | 4 | 5.8 | CC(Cc1ccc2ccccc2c1)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccc1)CC(=O)O | 10.1021/jm00072a005 | |||
10696354 | 120267 | 0 | None | -74 | 2 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 488 | 5 | 2 | 3 | 5.5 | CC(C)(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2F)c2ccccc21 | 10.1021/jm990967h | |||
CHEMBL331971 | 120267 | 0 | None | -74 | 2 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 488 | 5 | 2 | 3 | 5.5 | CC(C)(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2F)c2ccccc21 | 10.1021/jm990967h | |||
16100410 | 148576 | 0 | None | -6309 | 4 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 1031 | 27 | 13 | 12 | 0.2 | CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@H](Cc1cc2ccccc2[nH]1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm061268p | |||
CHEMBL386212 | 148576 | 0 | None | -6309 | 4 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 1031 | 27 | 13 | 12 | 0.2 | CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@H](Cc1cc2ccccc2[nH]1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm061268p | |||
9850043 | 119333 | 2 | None | -309 | 2 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 534 | 5 | 2 | 3 | 6.1 | O=C(Nc1ccccc1)NC1C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc2N(c2ccccc2)C1=O | 10.1016/S0960-894X(96)00544-6 | |||
CHEMBL329984 | 119333 | 2 | None | -309 | 2 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 534 | 5 | 2 | 3 | 6.1 | O=C(Nc1ccccc1)NC1C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc2N(c2ccccc2)C1=O | 10.1016/S0960-894X(96)00544-6 | |||
9850043 | 119650 | 2 | None | -446 | 3 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 534 | 5 | 2 | 3 | 6.1 | O=C(Nc1ccccc1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O | 10.1021/jm990967h | |||
CHEMBL330977 | 119650 | 2 | None | -446 | 3 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 534 | 5 | 2 | 3 | 6.1 | O=C(Nc1ccccc1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O | 10.1021/jm990967h | |||
44425005 | 149232 | 0 | None | -79 | 2 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 478 | 7 | 2 | 5 | 4.2 | CC(C)C1=NN(CC(=O)Nc2cccc(C(=O)O)c2)C(=O)N(CC(=O)C(C)(C)C)c2ccccc21 | 10.1021/jm070139l | |||
CHEMBL389019 | 149232 | 0 | None | -79 | 2 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 478 | 7 | 2 | 5 | 4.2 | CC(C)C1=NN(CC(=O)Nc2cccc(C(=O)O)c2)C(=O)N(CC(=O)C(C)(C)C)c2ccccc21 | 10.1021/jm070139l | |||
136036821 | 102583 | 0 | None | -3 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 602 | 9 | 2 | 7 | 5.6 | CC(C)(C)C(=O)CN1C(=O)N(CCCC(=O)Nc2cccc(-c3nc(=O)o[nH]3)c2)C(=O)N(C2CCCCC2)c2ccccc21 | 10.1016/j.bmc.2007.12.047 | |||
CHEMBL258782 | 102583 | 0 | None | -3 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 602 | 9 | 2 | 7 | 5.6 | CC(C)(C)C(=O)CN1C(=O)N(CCCC(=O)Nc2cccc(-c3nc(=O)o[nH]3)c2)C(=O)N(C2CCCCC2)c2ccccc21 | 10.1016/j.bmc.2007.12.047 | |||
9958214 | 121571 | 0 | None | -269 | 2 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 517 | 7 | 2 | 4 | 5.1 | CC(C)CCN1C(=O)C(NC(=O)Nc2cccc(N(C)C)c2)C(=O)N(c2ccccc2F)c2ccccc21 | 10.1021/jm990967h | |||
CHEMBL333979 | 121571 | 0 | None | -269 | 2 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 517 | 7 | 2 | 4 | 5.1 | CC(C)CCN1C(=O)C(NC(=O)Nc2cccc(N(C)C)c2)C(=O)N(c2ccccc2F)c2ccccc21 | 10.1021/jm990967h | |||
11613179 | 78563 | 0 | None | -83 | 3 | Guinea pig | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 511 | 7 | 3 | 3 | 7.1 | Cc1cc(C)c(-c2nc(C(=O)Nc3cccc(C(=O)O)c3)c(CCC34CC5CC(CC(C5)C3)C4)[nH]2)c(C)c1 | 10.1021/jm0490686 | |||
CHEMBL196745 | 78563 | 0 | None | -83 | 3 | Guinea pig | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 511 | 7 | 3 | 3 | 7.1 | Cc1cc(C)c(-c2nc(C(=O)Nc3cccc(C(=O)O)c3)c(CCC34CC5CC(CC(C5)C3)C4)[nH]2)c(C)c1 | 10.1021/jm0490686 | |||
11555166 | 146608 | 0 | None | -54 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 502 | 7 | 2 | 5 | 5.5 | CNc1cccc(NC(=O)C[C@H]2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1021/jm051219x | |||
CHEMBL379902 | 146608 | 0 | None | -54 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 502 | 7 | 2 | 5 | 5.5 | CNc1cccc(NC(=O)C[C@H]2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1021/jm051219x | |||
44356654 | 34882 | 0 | None | 1 | 2 | Guinea pig | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 691 | 9 | 3 | 3 | 7.8 | Cc1ccc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc1C | 10.1021/jm00021a019 | |||
CHEMBL137308 | 34882 | 0 | None | 1 | 2 | Guinea pig | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 691 | 9 | 3 | 3 | 7.8 | Cc1ccc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc1C | 10.1021/jm00021a019 | |||
10555899 | 120150 | 0 | None | -2344 | 2 | Rat | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 623 | 8 | 5 | 6 | 5.2 | CC(O)C(O)Nc1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 | 10.1021/jm990967h | |||
CHEMBL331763 | 120150 | 0 | None | -2344 | 2 | Rat | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 623 | 8 | 5 | 6 | 5.2 | CC(O)C(O)Nc1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 | 10.1021/jm990967h | |||
9986662 | 108805 | 10 | None | -977 | 2 | Guinea pig | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 643 | 11 | 6 | 6 | 4.8 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2F)NC(=O)c2cc3[nH]cnc3cc2C(=O)NCC2CCCCCC2)cc(C(=O)O)c1 | 10.1021/jm9508907 | |||
CHEMBL301777 | 108805 | 10 | None | -977 | 2 | Guinea pig | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 643 | 11 | 6 | 6 | 4.8 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2F)NC(=O)c2cc3[nH]cnc3cc2C(=O)NCC2CCCCCC2)cc(C(=O)O)c1 | 10.1021/jm9508907 | |||
44346825 | 121551 | 0 | None | -77 | 2 | Guinea pig | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 623 | 8 | 3 | 4 | 4.7 | C[C@@H](NC(=O)C[C@@H]1CCCN1C(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC1C2CC3CC(C2)CC1C3)C(=O)O | 10.1021/jm00048a001 | |||
CHEMBL333920 | 121551 | 0 | None | -77 | 2 | Guinea pig | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 623 | 8 | 3 | 4 | 4.7 | C[C@@H](NC(=O)C[C@@H]1CCCN1C(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC1C2CC3CC(C2)CC1C3)C(=O)O | 10.1021/jm00048a001 | |||
11802426 | 107059 | 0 | None | -50 | 2 | Guinea pig | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 653 | 8 | 3 | 5 | 6.5 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1C[C@H](Oc2ccc(Cl)cc2Cl)C[C@@H]1C(=O)O | 10.1016/s0960-894x(98)00231-5 | |||
CHEMBL289021 | 107059 | 0 | None | -50 | 2 | Guinea pig | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 653 | 8 | 3 | 5 | 6.5 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1C[C@H](Oc2ccc(Cl)cc2Cl)C[C@@H]1C(=O)O | 10.1016/s0960-894x(98)00231-5 | |||
10255015 | 215082 | 0 | None | 4 | 2 | Guinea pig | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 490 | 8 | 4 | 2 | 5.8 | CC(Cc1c[nH]c2ccccc12)(NC(=O)Nc1ccc2ccccc2c1)C(=O)NCCc1ccccc1 | 10.1021/jm00072a005 | |||
CHEMBL99065 | 215082 | 0 | None | 4 | 2 | Guinea pig | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 490 | 8 | 4 | 2 | 5.8 | CC(Cc1c[nH]c2ccccc12)(NC(=O)Nc1ccc2ccccc2c1)C(=O)NCCc1ccccc1 | 10.1021/jm00072a005 | |||
44346176 | 120111 | 0 | None | -21 | 2 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 496 | 6 | 3 | 3 | 6.2 | CC(CC1CCCC1)c1cccc2c1NC(=O)C(NC(=O)Nc1ccccc1)C(=O)N2c1ccccc1 | 10.1021/jm990967h | |||
CHEMBL331651 | 120111 | 0 | None | -21 | 2 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 496 | 6 | 3 | 3 | 6.2 | CC(CC1CCCC1)c1cccc2c1NC(=O)C(NC(=O)Nc1ccccc1)C(=O)N2c1ccccc1 | 10.1021/jm990967h | |||
11498528 | 79251 | 0 | None | -1096 | 3 | Guinea pig | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 503 | 7 | 3 | 4 | 6.1 | O=C(O)c1cccc(NC(=O)c2[nH]c(C34CCC(CC3)CC4)nc2COC23CC4CC(CC(C4)C2)C3)c1 | 10.1021/jm0490686 | |||
CHEMBL198933 | 79251 | 0 | None | -1096 | 3 | Guinea pig | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 503 | 7 | 3 | 4 | 6.1 | O=C(O)c1cccc(NC(=O)c2[nH]c(C34CCC(CC3)CC4)nc2COC23CC4CC(CC(C4)C2)C3)c1 | 10.1021/jm0490686 | |||
CHEMBL384035 | 219095 | 4 | None | -8 | 4 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/S0960-894X(00)80678-2 | |||||
CHEMBL428666 | 219095 | 4 | None | -8 | 4 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/S0960-894X(00)80678-2 | |||||
9914672 | 115319 | 0 | None | -31 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 521 | 5 | 2 | 4 | 3.7 | O=C(Nc1ccc(F)cc1)N[C@H]1C(=O)N(CC(=O)N2CCCC2)c2ccccc2N(C2CCCCC2)C1=O | 10.1016/j.bmc.2007.12.047 | |||
CHEMBL320141 | 115319 | 0 | None | -31 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 521 | 5 | 2 | 4 | 3.7 | O=C(Nc1ccc(F)cc1)N[C@H]1C(=O)N(CC(=O)N2CCCC2)c2ccccc2N(C2CCCCC2)C1=O | 10.1016/j.bmc.2007.12.047 | |||
11534407 | 203714 | 0 | None | 6 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 584 | 8 | 3 | 7 | 4.9 | O=C(N[C@H](Cc1ccc(Cl)c(Cl)c1)C(=O)O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 | 10.1016/j.bmcl.2009.09.064 | |||
CHEMBL566359 | 203714 | 0 | None | 6 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 584 | 8 | 3 | 7 | 4.9 | O=C(N[C@H](Cc1ccc(Cl)c(Cl)c1)C(=O)O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 | 10.1016/j.bmcl.2009.09.064 | |||
11627917 | 204309 | 0 | None | 7 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 530 | 7 | 2 | 6 | 4.8 | CC(CNC(=O)c1ccc(Br)cc1NS(=O)(=O)c1cccc2nsnc12)c1ccccc1 | 10.1016/j.bmcl.2009.09.064 | |||
CHEMBL570163 | 204309 | 0 | None | 7 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 530 | 7 | 2 | 6 | 4.8 | CC(CNC(=O)c1ccc(Br)cc1NS(=O)(=O)c1cccc2nsnc12)c1ccccc1 | 10.1016/j.bmcl.2009.09.064 | |||
45487003 | 204369 | 0 | None | 100 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 540 | 7 | 2 | 6 | 5.4 | O=C(NCCc1ccc(Cl)c(Cl)c1)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 | 10.1016/j.bmcl.2009.09.064 | |||
CHEMBL570521 | 204369 | 0 | None | 100 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 540 | 7 | 2 | 6 | 5.4 | O=C(NCCc1ccc(Cl)c(Cl)c1)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 | 10.1016/j.bmcl.2009.09.064 | |||
11584582 | 205647 | 0 | None | 19 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 530 | 7 | 2 | 6 | 4.8 | C[C@@H](CNC(=O)c1ccc(Br)cc1NS(=O)(=O)c1cccc2nsnc12)c1ccccc1 | 10.1016/j.bmcl.2009.09.064 | |||
CHEMBL584063 | 205647 | 0 | None | 19 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 530 | 7 | 2 | 6 | 4.8 | C[C@@H](CNC(=O)c1ccc(Br)cc1NS(=O)(=O)c1cccc2nsnc12)c1ccccc1 | 10.1016/j.bmcl.2009.09.064 | |||
9914672 | 115319 | 0 | None | -31 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 521 | 5 | 2 | 4 | 3.7 | O=C(Nc1ccc(F)cc1)N[C@H]1C(=O)N(CC(=O)N2CCCC2)c2ccccc2N(C2CCCCC2)C1=O | 10.1016/S0960-894X(96)00613-0 | |||
CHEMBL320141 | 115319 | 0 | None | -31 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 521 | 5 | 2 | 4 | 3.7 | O=C(Nc1ccc(F)cc1)N[C@H]1C(=O)N(CC(=O)N2CCCC2)c2ccccc2N(C2CCCCC2)C1=O | 10.1016/S0960-894X(96)00613-0 | |||
44329156 | 214413 | 0 | None | -50 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 535 | 5 | 2 | 4 | 4.0 | O=C(Nc1ccc(F)cc1)N[C@H]1C(=O)N(CC(=O)N2CCCC2)c2ccccc2N(C2CCCCCC2)C1=O | 10.1016/S0960-894X(96)00613-0 | |||
CHEMBL95200 | 214413 | 0 | None | -50 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 535 | 5 | 2 | 4 | 4.0 | O=C(Nc1ccc(F)cc1)N[C@H]1C(=O)N(CC(=O)N2CCCC2)c2ccccc2N(C2CCCCCC2)C1=O | 10.1016/S0960-894X(96)00613-0 | |||
11505870 | 79282 | 0 | None | -2 | 3 | Guinea pig | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 526 | 8 | 3 | 4 | 6.6 | Cc1ccccc1-c1nc(CCC23CC4CC(CC(C4)C2)C3)c(C(=O)Nc2ccc(N(C)C)c(C(=O)O)c2)[nH]1 | 10.1021/jm0490686 | |||
CHEMBL199032 | 79282 | 0 | None | -2 | 3 | Guinea pig | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 526 | 8 | 3 | 4 | 6.6 | Cc1ccccc1-c1nc(CCC23CC4CC(CC(C4)C2)C3)c(C(=O)Nc2ccc(N(C)C)c(C(=O)O)c2)[nH]1 | 10.1021/jm0490686 | |||
10652143 | 101375 | 0 | None | - | 1 | Guinea pig | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 679 | 11 | 5 | 6 | 6.2 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3sccc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm070880t | |||
CHEMBL252150 | 101375 | 0 | None | - | 1 | Guinea pig | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 679 | 11 | 5 | 6 | 6.2 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3sccc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm070880t | |||
11802624 | 108813 | 0 | None | -64 | 2 | Guinea pig | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 673 | 11 | 5 | 5 | 6.2 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3ccccc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm070880t | |||
CHEMBL2067966 | 108813 | 0 | None | -64 | 2 | Guinea pig | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 673 | 11 | 5 | 5 | 6.2 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3ccccc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm070880t | |||
CHEMBL301810 | 108813 | 0 | None | -64 | 2 | Guinea pig | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 673 | 11 | 5 | 5 | 6.2 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3ccccc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm070880t | |||
44331479 | 11144 | 0 | None | -27 | 2 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 494 | 9 | 1 | 5 | 4.7 | CC(C)CCN1C(=O)C(NC(=O)Oc2cccc(N(C)C)c2)C(=O)N(CCC(C)C)c2ccccc21 | 10.1016/S0960-894X(96)00544-6 | |||
CHEMBL101208 | 11144 | 0 | None | -27 | 2 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 494 | 9 | 1 | 5 | 4.7 | CC(C)CCN1C(=O)C(NC(=O)Oc2cccc(N(C)C)c2)C(=O)N(CCC(C)C)c2ccccc21 | 10.1016/S0960-894X(96)00544-6 | |||
11802624 | 108813 | 0 | None | -64 | 2 | Guinea pig | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 673 | 11 | 5 | 5 | 6.2 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3ccccc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm049069y | |||
CHEMBL2067966 | 108813 | 0 | None | -64 | 2 | Guinea pig | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 673 | 11 | 5 | 5 | 6.2 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3ccccc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm049069y | |||
CHEMBL301810 | 108813 | 0 | None | -64 | 2 | Guinea pig | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 673 | 11 | 5 | 5 | 6.2 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3ccccc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm049069y | |||
10555325 | 19721 | 0 | None | -45 | 2 | Guinea pig | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 585 | 7 | 2 | 5 | 4.2 | CC(=O)N1[C@H](C(=O)NCC(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 | 10.1021/jm070880t | |||
CHEMBL118930 | 19721 | 0 | None | -45 | 2 | Guinea pig | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 585 | 7 | 2 | 5 | 4.2 | CC(=O)N1[C@H](C(=O)NCC(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 | 10.1021/jm070880t | |||
44272229 | 105521 | 0 | None | - | 1 | Guinea pig | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 635 | 15 | 6 | 6 | 3.5 | CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 | 10.1021/jm070880t | |||
CHEMBL278032 | 105521 | 0 | None | - | 1 | Guinea pig | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 635 | 15 | 6 | 6 | 3.5 | CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 | 10.1021/jm070880t | |||
16090701 | 148532 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 383 | 4 | 2 | 3 | 3.6 | O=C(c1ccccc1NS(=O)(=O)c1cc2ccccc2[nH]1)N1CCCCC1 | 10.1021/jm060590x | |||
CHEMBL385963 | 148532 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 383 | 4 | 2 | 3 | 3.6 | O=C(c1ccccc1NS(=O)(=O)c1cc2ccccc2[nH]1)N1CCCCC1 | 10.1021/jm060590x | |||
16732755 | 92225 | 0 | None | -10000 | 2 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 544 | 8 | 2 | 5 | 5.7 | O=C(CN1N=C(C2CCCCC2)c2ccccc2N(CC(=O)C2CCCCC2)C1=O)Nc1cccc(C(=O)O)c1 | 10.1021/jm070139l | |||
CHEMBL226622 | 92225 | 0 | None | -10000 | 2 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 544 | 8 | 2 | 5 | 5.7 | O=C(CN1N=C(C2CCCCC2)c2ccccc2N(CC(=O)C2CCCCC2)C1=O)Nc1cccc(C(=O)O)c1 | 10.1021/jm070139l | |||
11518254 | 18573 | 0 | None | -31 | 2 | Guinea pig | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 460 | 7 | 4 | 3 | 5.8 | O=C(O)c1cc(NC(=O)c2cc(-c3ccccc3)[nH]c2CC2CCCCCC2)cc(C(=O)O)c1 | 10.1021/jm049069y | |||
CHEMBL1181918 | 18573 | 0 | None | -31 | 2 | Guinea pig | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 460 | 7 | 4 | 3 | 5.8 | O=C(O)c1cc(NC(=O)c2cc(-c3ccccc3)[nH]c2CC2CCCCCC2)cc(C(=O)O)c1 | 10.1021/jm049069y | |||
CHEMBL2067948 | 18573 | 0 | None | -31 | 2 | Guinea pig | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 460 | 7 | 4 | 3 | 5.8 | O=C(O)c1cc(NC(=O)c2cc(-c3ccccc3)[nH]c2CC2CCCCCC2)cc(C(=O)O)c1 | 10.1021/jm049069y | |||
9870515 | 19033 | 0 | None | -63 | 2 | Guinea pig | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 498 | 7 | 4 | 3 | 6.1 | O=C(O)c1cc(NC(=O)c2cc(-c3ccccc3)[nH]c2CC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm049069y | |||
CHEMBL1184696 | 19033 | 0 | None | -63 | 2 | Guinea pig | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 498 | 7 | 4 | 3 | 6.1 | O=C(O)c1cc(NC(=O)c2cc(-c3ccccc3)[nH]c2CC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm049069y | |||
CHEMBL2067955 | 19033 | 0 | None | -63 | 2 | Guinea pig | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 498 | 7 | 4 | 3 | 6.1 | O=C(O)c1cc(NC(=O)c2cc(-c3ccccc3)[nH]c2CC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm049069y | |||
11554414 | 19052 | 0 | None | -7 | 2 | Guinea pig | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 461 | 7 | 4 | 4 | 5.2 | O=C(O)c1cc(NC(=O)c2[nH]c(-c3ccccc3)nc2CC2CCCCCC2)cc(C(=O)O)c1 | 10.1021/jm049069y | |||
CHEMBL1184820 | 19052 | 0 | None | -7 | 2 | Guinea pig | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 461 | 7 | 4 | 4 | 5.2 | O=C(O)c1cc(NC(=O)c2[nH]c(-c3ccccc3)nc2CC2CCCCCC2)cc(C(=O)O)c1 | 10.1021/jm049069y | |||
CHEMBL2067965 | 19052 | 0 | None | -7 | 2 | Guinea pig | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 461 | 7 | 4 | 4 | 5.2 | O=C(O)c1cc(NC(=O)c2[nH]c(-c3ccccc3)nc2CC2CCCCCC2)cc(C(=O)O)c1 | 10.1021/jm049069y | |||
CHEMBL320868 | 218008 | 0 | None | 70 | 2 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | None | None | None | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm990252e | |||||
CHEMBL3351060 | 218320 | 0 | None | 20 | 2 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | None | None | None | CN(C(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1cccc2ccccc12)c1ccccc1)[C@@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C | 10.1021/jm00053a022 | |||||
4627 | 7609 | 50 | None | -1 | 5 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00389a002 | |||||
864 | 7609 | 50 | None | -1 | 5 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00389a002 | |||||
9833444 | 7609 | 50 | None | -1 | 5 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00389a002 | |||||
CHEMBL1121 | 7609 | 50 | None | -1 | 5 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00389a002 | |||||
DB09142 | 7609 | 50 | None | -1 | 5 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00389a002 | |||||
10027864 | 114059 | 0 | None | - | 1 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 474 | 6 | 2 | 3 | 5.1 | CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccc(F)cc21 | 10.1016/0960-894X(95)00528-2 | |||
CHEMBL317081 | 114059 | 0 | None | - | 1 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 474 | 6 | 2 | 3 | 5.1 | CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccc(F)cc21 | 10.1016/0960-894X(95)00528-2 | |||
44265928 | 214054 | 0 | None | - | 1 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 342 | 5 | 2 | 1 | 5.2 | Cc1cccc(NC(=O)NCC=C(c2ccccc2)c2ccccc2)c1 | 10.1021/jm00084a009 | |||
CHEMBL9312 | 214054 | 0 | None | - | 1 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 342 | 5 | 2 | 1 | 5.2 | Cc1cccc(NC(=O)NCC=C(c2ccccc2)c2ccccc2)c1 | 10.1021/jm00084a009 | |||
CHEMBL3351049 | 218312 | 0 | None | -2 | 2 | Guinea pig | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | None | None | None | CN(C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1ccccc1)[C@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C | 10.1021/jm00053a022 | |||||
10651325 | 20650 | 0 | None | -275 | 2 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 606 | 7 | 2 | 5 | 6.3 | CCOC(=O)c1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 | 10.1021/jm990967h | |||
CHEMBL119608 | 20650 | 0 | None | -275 | 2 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 606 | 7 | 2 | 5 | 6.3 | CCOC(=O)c1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 | 10.1021/jm990967h | |||
16732592 | 150360 | 1 | None | -870 | 2 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 572 | 8 | 2 | 7 | 4.9 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2ccc3c(cnn3CC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
CHEMBL389933 | 150360 | 1 | None | -870 | 2 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 572 | 8 | 2 | 7 | 4.9 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2ccc3c(cnn3CC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
44296980 | 108799 | 0 | None | -9 | 2 | Guinea pig | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 538 | 5 | 2 | 3 | 4.9 | O=C(NCC12CC3CC(CC(C3)C1)C2)C1C2c3ccccc3C(c3ccccc32)C1C(=O)N1CCC[C@@H]1C(=O)O | 10.1021/jm9508907 | |||
CHEMBL301740 | 108799 | 0 | None | -9 | 2 | Guinea pig | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 538 | 5 | 2 | 3 | 4.9 | O=C(NCC12CC3CC(CC(C3)C1)C2)C1C2c3ccccc3C(c3ccccc32)C1C(=O)N1CCC[C@@H]1C(=O)O | 10.1021/jm9508907 | |||
44346952 | 120890 | 0 | None | -9 | 2 | Guinea pig | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 538 | 5 | 2 | 3 | 4.8 | O=C(NCC1C2CC3CC(C2)CC1C3)C1C2c3ccccc3C(c3ccccc32)C1C(=O)N1CCC[C@@H]1C(=O)O | 10.1021/jm00048a001 | |||
CHEMBL332782 | 120890 | 0 | None | -9 | 2 | Guinea pig | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 538 | 5 | 2 | 3 | 4.8 | O=C(NCC1C2CC3CC(C2)CC1C3)C1C2c3ccccc3C(c3ccccc32)C1C(=O)N1CCC[C@@H]1C(=O)O | 10.1021/jm00048a001 | |||
10674395 | 117550 | 0 | None | - | 1 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 559 | 7 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@H]12 | 10.1021/jm9703247 | |||
CHEMBL326064 | 117550 | 0 | None | - | 1 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 559 | 7 | 3 | 5 | 4.1 | CC(C)(C)OC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@H]12 | 10.1021/jm9703247 | |||
44331489 | 11047 | 0 | None | -32 | 2 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 493 | 9 | 2 | 4 | 4.7 | CC(C)CCN1C(=O)C(NC(=O)Nc2cccc(N(C)C)c2)C(=O)N(CCC(C)C)c2ccccc21 | 10.1016/S0960-894X(96)00544-6 | |||
CHEMBL100618 | 11047 | 0 | None | -32 | 2 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 493 | 9 | 2 | 4 | 4.7 | CC(C)CCN1C(=O)C(NC(=O)Nc2cccc(N(C)C)c2)C(=O)N(CCC(C)C)c2ccccc21 | 10.1016/S0960-894X(96)00544-6 | |||
10768658 | 121580 | 0 | None | -42 | 2 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 534 | 5 | 2 | 3 | 6.0 | O=C(Nc1ccccc1)NC1C(=O)N(CC2[C@H]3C[C@@H]4C[C@@H](C[C@H]2C4)C3)c2ccccc2N(c2ccccc2)C1=O | 10.1021/jm990967h | |||
CHEMBL334020 | 121580 | 0 | None | -42 | 2 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 534 | 5 | 2 | 3 | 6.0 | O=C(Nc1ccccc1)NC1C(=O)N(CC2[C@H]3C[C@@H]4C[C@@H](C[C@H]2C4)C3)c2ccccc2N(c2ccccc2)C1=O | 10.1021/jm990967h | |||
16100408 | 148569 | 0 | None | -1202 | 3 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 1132 | 28 | 13 | 13 | 1.7 | CCCC[C@@H](NC(=O)[C@H](Cc1cc2ccccc2[nH]1)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(=O)O)C(=O)N[C@H](Cc1ccccc1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm061268p | |||
CHEMBL386186 | 148569 | 0 | None | -1202 | 3 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 1132 | 28 | 13 | 13 | 1.7 | CCCC[C@@H](NC(=O)[C@H](Cc1cc2ccccc2[nH]1)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(=O)O)C(=O)N[C@H](Cc1ccccc1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm061268p | |||
19700621 | 70920 | 0 | None | - | 1 | Rat | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 509 | 8 | 3 | 6 | 2.6 | CC(C)CCN1C(=O)C(NC(=O)Nc2ccc(O)cc2)C(=O)N(CCN2CCOCC2)c2ccccc21 | 10.1016/j.bmc.2011.05.057 | |||
CHEMBL1808409 | 70920 | 0 | None | - | 1 | Rat | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 509 | 8 | 3 | 6 | 2.6 | CC(C)CCN1C(=O)C(NC(=O)Nc2ccc(O)cc2)C(=O)N(CCN2CCOCC2)c2ccccc21 | 10.1016/j.bmc.2011.05.057 | |||
15249830 | 108712 | 0 | None | -15 | 2 | Guinea pig | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 441 | 4 | 2 | 2 | 4.9 | O=C(O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC12CC3CC(CC(C3)C1)C2 | 10.1021/jm9508907 | |||
CHEMBL301095 | 108712 | 0 | None | -15 | 2 | Guinea pig | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 441 | 4 | 2 | 2 | 4.9 | O=C(O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC12CC3CC(CC(C3)C1)C2 | 10.1021/jm9508907 | |||
44347142 | 120908 | 0 | None | -15 | 2 | Guinea pig | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 441 | 4 | 2 | 2 | 4.8 | O=C(O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC1C2CC3CC(C2)CC1C3 | 10.1021/jm00048a001 | |||
CHEMBL332873 | 120908 | 0 | None | -15 | 2 | Guinea pig | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 441 | 4 | 2 | 2 | 4.8 | O=C(O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC1C2CC3CC(C2)CC1C3 | 10.1021/jm00048a001 | |||
44408632 | 165016 | 0 | None | -3630 | 4 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 1212 | 31 | 12 | 15 | 3.8 | CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@H](Cc1cn(C(=O)OC23CC4CC(CC(C4)C2)C3)c2ccccc12)C(=O)O | 10.1021/jm050851n | |||
CHEMBL408832 | 165016 | 0 | None | -3630 | 4 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 1212 | 31 | 12 | 15 | 3.8 | CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@H](Cc1cn(C(=O)OC23CC4CC(CC(C4)C2)C3)c2ccccc12)C(=O)O | 10.1021/jm050851n | |||
11802624 | 108813 | 0 | None | -64 | 2 | Guinea pig | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 673 | 11 | 5 | 5 | 6.2 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3ccccc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm9508907 | |||
CHEMBL2067966 | 108813 | 0 | None | -64 | 2 | Guinea pig | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 673 | 11 | 5 | 5 | 6.2 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3ccccc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm9508907 | |||
CHEMBL301810 | 108813 | 0 | None | -64 | 2 | Guinea pig | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 673 | 11 | 5 | 5 | 6.2 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3ccccc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm9508907 | |||
16733463 | 20774 | 0 | None | -1380 | 2 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 547 | 9 | 3 | 6 | 5.0 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(NCC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
CHEMBL1197033 | 20774 | 0 | None | -1380 | 2 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 547 | 9 | 3 | 6 | 5.0 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(NCC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
CHEMBL559157 | 20774 | 0 | None | -1380 | 2 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 547 | 9 | 3 | 6 | 5.0 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(NCC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
44346947 | 22069 | 0 | None | 1 | 2 | Guinea pig | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 389 | 4 | 2 | 2 | 4.3 | O=C(O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC1CCCCC1 | 10.1021/jm00048a001 | |||
CHEMBL121342 | 22069 | 0 | None | 1 | 2 | Guinea pig | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 389 | 4 | 2 | 2 | 4.3 | O=C(O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC1CCCCC1 | 10.1021/jm00048a001 | |||
CHEMBL336381 | 218362 | 0 | None | -354 | 5 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm0303103 | |||||
11584903 | 147517 | 0 | None | -295 | 3 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 560 | 10 | 2 | 6 | 5.1 | CNCCN(C)c1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1021/jm051219x | |||
CHEMBL381805 | 147517 | 0 | None | -295 | 3 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 560 | 10 | 2 | 6 | 5.1 | CNCCN(C)c1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1021/jm051219x | |||
10604847 | 201456 | 0 | None | -218 | 2 | Guinea pig | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 711 | 11 | 6 | 10 | 3.8 | O=C(NCC12CC3CC(CC(C3)C1)C2)c1cc2nc[nH]c2cc1C(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1cc(-c2nn[nH]n2)cc(-c2nn[nH]n2)c1 | 10.1021/jm9508907 | |||
CHEMBL53237 | 201456 | 0 | None | -218 | 2 | Guinea pig | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 711 | 11 | 6 | 10 | 3.8 | O=C(NCC12CC3CC(CC(C3)C1)C2)c1cc2nc[nH]c2cc1C(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1cc(-c2nn[nH]n2)cc(-c2nn[nH]n2)c1 | 10.1021/jm9508907 | |||
CHEMBL1172252 | 215363 | 0 | None | -12 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/j.bmcl.2010.05.078 | |||||
CHEMBL208479 | 215978 | 0 | None | -3 | 4 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](CCCC)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm050921q | |||||
19043361 | 11391 | 0 | None | 162 | 2 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 524 | 6 | 2 | 3 | 6.2 | CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2cc(Cl)c(Cl)cc21 | 10.1016/0960-894X(95)00528-2 | |||
CHEMBL102867 | 11391 | 0 | None | 162 | 2 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 524 | 6 | 2 | 3 | 6.2 | CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2cc(Cl)c(Cl)cc21 | 10.1016/0960-894X(95)00528-2 | |||
44265973 | 214049 | 0 | None | - | 1 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 362 | 5 | 2 | 1 | 5.6 | O=C(NCC=C(c1ccccc1)c1ccccc1)Nc1ccc(Cl)cc1 | 10.1021/jm00084a009 | |||
CHEMBL9308 | 214049 | 0 | None | - | 1 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 362 | 5 | 2 | 1 | 5.6 | O=C(NCC=C(c1ccccc1)c1ccccc1)Nc1ccc(Cl)cc1 | 10.1021/jm00084a009 | |||
CHEMBL408083 | 219477 | 0 | None | -2 | 4 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](CCCC)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm050921q | |||||
46235271 | 80423 | 2 | None | 2 | 2 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 649 | 7 | 1 | 6 | 6.7 | Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1021/acs.jmedchem.5b01110 | |||
CHEMBL2017835 | 80423 | 2 | None | 2 | 2 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 649 | 7 | 1 | 6 | 6.7 | Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1021/acs.jmedchem.5b01110 | |||
10580503 | 108467 | 0 | None | -234 | 2 | Guinea pig | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 691 | 11 | 6 | 10 | 3.7 | O=C(NCC1CCCCCC1)c1cc2nc[nH]c2cc1C(=O)N[C@@H](Cc1ccccc1F)C(=O)Nc1cc(-c2nn[nH]n2)cc(-c2nn[nH]n2)c1 | 10.1021/jm9508907 | |||
CHEMBL299387 | 108467 | 0 | None | -234 | 2 | Guinea pig | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 691 | 11 | 6 | 10 | 3.7 | O=C(NCC1CCCCCC1)c1cc2nc[nH]c2cc1C(=O)N[C@@H](Cc1ccccc1F)C(=O)Nc1cc(-c2nn[nH]n2)cc(-c2nn[nH]n2)c1 | 10.1021/jm9508907 | |||
44356430 | 122009 | 0 | None | -70 | 2 | Guinea pig | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 769 | 11 | 5 | 5 | 6.7 | O=C(O)c1cc(NC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm00021a019 | |||
CHEMBL334714 | 122009 | 0 | None | -70 | 2 | Guinea pig | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 769 | 11 | 5 | 5 | 6.7 | O=C(O)c1cc(NC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1021/jm00021a019 | |||
21476261 | 11067 | 0 | None | -169 | 2 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 571 | 8 | 2 | 4 | 5.9 | CC(C)CCN1C(=O)C(NC(=O)Nc2cccc(N(C)C)c2)C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc21 | 10.1016/S0960-894X(96)00544-6 | |||
CHEMBL100776 | 11067 | 0 | None | -169 | 2 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 571 | 8 | 2 | 4 | 5.9 | CC(C)CCN1C(=O)C(NC(=O)Nc2cccc(N(C)C)c2)C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc21 | 10.1016/S0960-894X(96)00544-6 | |||
44357011 | 123348 | 0 | None | 1 | 2 | Guinea pig | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 779 | 11 | 3 | 7 | 6.8 | COC(=O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)OC)c1 | 10.1021/jm00021a019 | |||
CHEMBL336453 | 123348 | 0 | None | 1 | 2 | Guinea pig | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 779 | 11 | 3 | 7 | 6.8 | COC(=O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)OC)c1 | 10.1021/jm00021a019 | |||
44212463 | 70930 | 0 | None | - | 1 | Rat | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 555 | 7 | 2 | 4 | 4.9 | O=C(Nc1ccccc1)NC1C(=O)N(CCN2CCCC2)c2ccccc2N(CC23CC4CC(CC(C4)C2)C3)C1=O | 10.1016/j.bmc.2011.05.057 | |||
CHEMBL1808419 | 70930 | 0 | None | - | 1 | Rat | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 555 | 7 | 2 | 4 | 4.9 | O=C(Nc1ccccc1)NC1C(=O)N(CCN2CCCC2)c2ccccc2N(CC23CC4CC(CC(C4)C2)C3)C1=O | 10.1016/j.bmc.2011.05.057 | |||
CHEMBL411271 | 219654 | 0 | None | -630 | 3 | Guinea pig | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm0000416 | |||||
10838957 | 19244 | 0 | None | -151 | 2 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 495 | 5 | 2 | 4 | 5.2 | CC(C)(C)CCN1C(=O)C(NC(=O)Nc2cccc(C#N)c2)C(=O)N(c2ccccc2)c2ccccc21 | 10.1021/jm990967h | |||
CHEMBL118622 | 19244 | 0 | None | -151 | 2 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 495 | 5 | 2 | 4 | 5.2 | CC(C)(C)CCN1C(=O)C(NC(=O)Nc2cccc(C#N)c2)C(=O)N(c2ccccc2)c2ccccc21 | 10.1021/jm990967h | |||
44346326 | 120116 | 0 | None | -46 | 2 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 588 | 5 | 2 | 7 | 6.5 | O=C(Nc1cccc(C2N=NN=N2)c1)NC1C(=O)N(c2ccccc2)c2ccccc2N(C2[C@H]3C[C@@H]4C[C@@H](C[C@H]2C4)C3)C1=O | 10.1021/jm990967h | |||
CHEMBL331688 | 120116 | 0 | None | -46 | 2 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 588 | 5 | 2 | 7 | 6.5 | O=C(Nc1cccc(C2N=NN=N2)c1)NC1C(=O)N(c2ccccc2)c2ccccc2N(C2[C@H]3C[C@@H]4C[C@@H](C[C@H]2C4)C3)C1=O | 10.1021/jm990967h | |||
53465843 | 76185 | 0 | None | 1 | 2 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 441 | 8 | 4 | 3 | 4.2 | O=C(Nc1ccccc1C(=O)N[C@@H](CCc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 | 10.1021/jm200438b | |||
CHEMBL1933103 | 76185 | 0 | None | 1 | 2 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 441 | 8 | 4 | 3 | 4.2 | O=C(Nc1ccccc1C(=O)N[C@@H](CCc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 | 10.1021/jm200438b | |||
CHEMBL382051 | 219072 | 0 | None | -489 | 4 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm050921q | |||||
CHEMBL3351055 | 218318 | 0 | None | -70 | 2 | Guinea pig | 6.0 | pKi | = | 6 | Binding | ChEMBL | None | None | None | CC(C)(C)OC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1cccc2ccccc12)c1ccccc1 | 10.1021/jm00053a022 | |||||
2118 | 210264 | 36 | None | - | 2 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | Drug Central | 308 | 1 | 0 | 4 | 3.6 | Cc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1)=NC2 | None | |||
CHEMBL661 | 210264 | 36 | None | - | 2 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | Drug Central | 308 | 1 | 0 | 4 | 3.6 | Cc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1)=NC2 | None | |||
5556 | 210039 | 27 | None | - | 1 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | Drug Central | 342 | 1 | 0 | 4 | 4.2 | Cc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1Cl)=NC2 | None | |||
CHEMBL646 | 210039 | 27 | None | - | 1 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | Drug Central | 342 | 1 | 0 | 4 | 4.2 | Cc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1Cl)=NC2 | None | |||
11954224 | 222732 | 0 | None | - | 59 | Mouse | 8.4 | pIC50 | = | 8.4 | Binding | Drug Central | 581 | 4 | 3 | 6 | 2.0 | CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C | None | |||
9853654 | 29561 | 41 | None | - | 2 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 767 | 20 | 8 | 9 | 1.5 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | None | |||
CHEMBL1328 | 29561 | 41 | None | - | 2 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 767 | 20 | 8 | 9 | 1.5 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | None | |||
1614 | 9128 | 67 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 460 | 14 | 2 | 4 | 4.0 | CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCOC | None | |||
60182 | 9128 | 67 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 460 | 14 | 2 | 4 | 4.0 | CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCOC | None | |||
892 | 9128 | 67 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 460 | 14 | 2 | 4 | 4.0 | CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCOC | None | |||
CHEMBL206025 | 9128 | 67 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 460 | 14 | 2 | 4 | 4.0 | CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCOC | None | |||
16129670 | 7603 | 0 | None | 3 | 2 | Rat | 9.3 | pKd | = | 9.3 | Binding | Guide to Pharmacology | None | None | None | None | 6256771 | |||||
860 | 7603 | 0 | None | 3 | 2 | Rat | 9.3 | pKd | = | 9.3 | Binding | Guide to Pharmacology | None | None | None | None | 6256771 | |||||
91898395 | 7603 | 0 | None | 3 | 2 | Rat | 9.3 | pKd | = | 9.3 | Binding | Guide to Pharmacology | None | None | None | None | 6256771 | |||||
3476 | 8182 | 9 | None | 2 | 3 | Human | 9.7 | pKd | = | 9.7 | Binding | Guide to Pharmacology | 408 | 3 | 2 | 3 | 3.7 | O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 | 3018478 | |||
59751 | 8182 | 9 | None | 2 | 3 | Human | 9.7 | pKd | = | 9.7 | Binding | Guide to Pharmacology | 408 | 3 | 2 | 3 | 3.7 | O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 | 3018478 | |||
878 | 8182 | 9 | None | 2 | 3 | Human | 9.7 | pKd | = | 9.7 | Binding | Guide to Pharmacology | 408 | 3 | 2 | 3 | 3.7 | O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 | 3018478 | |||
CHEMBL39263 | 8182 | 9 | None | 2 | 3 | Human | 9.7 | pKd | = | 9.7 | Binding | Guide to Pharmacology | 408 | 3 | 2 | 3 | 3.7 | O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 | 3018478 | |||
4627 | 7609 | 50 | None | -1 | 5 | Rat | 8.0 | pKi | = | 8 | Binding | Drug Central | None | None | None | None | None | |||||
864 | 7609 | 50 | None | -1 | 5 | Rat | 8.0 | pKi | = | 8 | Binding | Drug Central | None | None | None | None | None | |||||
9833444 | 7609 | 50 | None | -1 | 5 | Rat | 8.0 | pKi | = | 8 | Binding | Drug Central | None | None | None | None | None | |||||
CHEMBL1121 | 7609 | 50 | None | -1 | 5 | Rat | 8.0 | pKi | = | 8 | Binding | Drug Central | None | None | None | None | None | |||||
DB09142 | 7609 | 50 | None | -1 | 5 | Rat | 8.0 | pKi | = | 8 | Binding | Drug Central | None | None | None | None | None | |||||
138106885 | 173690 | 75 | None | -1 | 4 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 853 | 10 | 4 | 14 | 3.7 | CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C | None | |||
36314 | 173690 | 75 | None | -1 | 4 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 853 | 10 | 4 | 14 | 3.7 | CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C | None | |||
CHEMBL428647 | 173690 | 75 | None | -1 | 4 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 853 | 10 | 4 | 14 | 3.7 | CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C | None | |||
4627 | 7609 | 50 | None | -2 | 5 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | None | None | None | None | None | |||||
864 | 7609 | 50 | None | -2 | 5 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | None | None | None | None | None | |||||
9833444 | 7609 | 50 | None | -2 | 5 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | None | None | None | None | None | |||||
CHEMBL1121 | 7609 | 50 | None | -2 | 5 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | None | None | None | None | None | |||||
DB09142 | 7609 | 50 | None | -2 | 5 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | None | None | None | None | None | |||||
4627 | 7609 | 50 | None | -1 | 5 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | Drug Central | None | None | None | None | None | |||||
864 | 7609 | 50 | None | -1 | 5 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | Drug Central | None | None | None | None | None | |||||
9833444 | 7609 | 50 | None | -1 | 5 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | Drug Central | None | None | None | None | None | |||||
CHEMBL1121 | 7609 | 50 | None | -1 | 5 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | Drug Central | None | None | None | None | None | |||||
DB09142 | 7609 | 50 | None | -1 | 5 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | Drug Central | None | None | None | None | None | |||||
859 | 7260 | 0 | None | 7943 | 2 | Rat | 10.5 | pKi | None | 10.5 | Binding | Guide to Pharmacology | None | None | None | None | 9476993 | |||||
3074331 | 7712 | 0 | None | - | 1 | Rat | 5.3 | pKi | None | 5.3 | Binding | Guide to Pharmacology | 493 | 6 | 4 | 4 | 4.6 | O=C(N[C@@](C(=O)N[C@H]1CCCC[C@@H]1O)(Cc1c[nH]c2c1cccc2)C)OC12CC3CC(C2)CC(C1)C3 | 9438020 | |||
872 | 7712 | 0 | None | - | 1 | Rat | 5.3 | pKi | None | 5.3 | Binding | Guide to Pharmacology | 493 | 6 | 4 | 4 | 4.6 | O=C(N[C@@](C(=O)N[C@H]1CCCC[C@@H]1O)(Cc1c[nH]c2c1cccc2)C)OC12CC3CC(C2)CC(C1)C3 | 9438020 | |||
132980 | 9020 | 12 | None | - | 1 | Rat | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | 445 | 2 | 2 | 4 | 4.0 | Cc1cccc(c1)NC(=O)N[C@@H]1N=C(N2CC3CCC(C2)CC3)c2c(N(C1=O)C)cccc2 | 7969084 | |||
881 | 9020 | 12 | None | - | 1 | Rat | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | 445 | 2 | 2 | 4 | 4.0 | Cc1cccc(c1)NC(=O)N[C@@H]1N=C(N2CC3CCC(C2)CC3)c2c(N(C1=O)C)cccc2 | 7969084 | |||
CHEMBL420783 | 9020 | 12 | None | - | 1 | Rat | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | 445 | 2 | 2 | 4 | 4.0 | Cc1cccc(c1)NC(=O)N[C@@H]1N=C(N2CC3CCC(C2)CC3)c2c(N(C1=O)C)cccc2 | 7969084 | |||
6439414 | 9799 | 14 | None | -2454 | 2 | Rat | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 612 | 11 | 5 | 5 | 4.6 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)/C=C/C(=O)O | 7516969 | |||
867 | 9799 | 14 | None | -2454 | 2 | Rat | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 612 | 11 | 5 | 5 | 4.6 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)/C=C/C(=O)O | 7516969 | |||
CHEMBL3351022 | 9799 | 14 | None | -2454 | 2 | Rat | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 612 | 11 | 5 | 5 | 4.6 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)/C=C/C(=O)O | 7516969 | |||
CHEMBL341460 | 9799 | 14 | None | -2454 | 2 | Rat | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 612 | 11 | 5 | 5 | 4.6 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)/C=C/C(=O)O | 7516969 | |||
122130 | 10887 | 39 | None | - | 1 | Rat | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 516 | 6 | 2 | 4 | 5.5 | Cc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccc2)c2c(N(C1=O)CC(=O)c1ccccc1C)cccc2 | 7910212 | |||
888 | 10887 | 39 | None | - | 1 | Rat | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 516 | 6 | 2 | 4 | 5.5 | Cc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccc2)c2c(N(C1=O)CC(=O)c1ccccc1C)cccc2 | 7910212 | |||
CHEMBL115121 | 10887 | 39 | None | - | 1 | Rat | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 516 | 6 | 2 | 4 | 5.5 | Cc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccc2)c2c(N(C1=O)CC(=O)c1ccccc1C)cccc2 | 7910212 | |||
65937 | 8185 | 0 | None | - | 1 | Human | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 460 | 14 | 2 | 4 | 4.0 | CCCCCN(C(=O)[C@H](NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCOC | 17684117 | |||
834 | 8185 | 0 | None | - | 1 | Human | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 460 | 14 | 2 | 4 | 4.0 | CCCCCN(C(=O)[C@H](NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCOC | 17684117 | |||
889 | 8185 | 0 | None | - | 1 | Human | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 460 | 14 | 2 | 4 | 4.0 | CCCCCN(C(=O)[C@H](NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCOC | 17684117 | |||
CHEMBL550781 | 8185 | 0 | None | - | 1 | Human | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 460 | 14 | 2 | 4 | 4.0 | CCCCCN(C(=O)[C@H](NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCOC | 17684117 | |||
DB04856 | 8185 | 0 | None | - | 1 | Human | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 460 | 14 | 2 | 4 | 4.0 | CCCCCN(C(=O)[C@H](NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCOC | 17684117 | |||
11488979 | 8917 | 0 | None | - | 1 | Human | 8.0 | pKi | None | 8 | Binding | Guide to Pharmacology | 480 | 7 | 1 | 4 | 6.6 | COc1ccc(cc1)n1nc(cc1c1ccc(c(c1)Cl)Cl)C[C@@H](c1cccc(c1)C)C(=O)O | 17684117 | |||
877 | 8917 | 0 | None | - | 1 | Human | 8.0 | pKi | None | 8 | Binding | Guide to Pharmacology | 480 | 7 | 1 | 4 | 6.6 | COc1ccc(cc1)n1nc(cc1c1ccc(c(c1)Cl)Cl)C[C@@H](c1cccc(c1)C)C(=O)O | 17684117 | |||
CHEMBL400111 | 8917 | 0 | None | - | 1 | Human | 8.0 | pKi | None | 8 | Binding | Guide to Pharmacology | 480 | 7 | 1 | 4 | 6.6 | COc1ccc(cc1)n1nc(cc1c1ccc(c(c1)Cl)Cl)C[C@@H](c1cccc(c1)C)C(=O)O | 17684117 | |||
885 | 10620 | 0 | None | 1584 | 2 | Rat | 8.9 | pKi | None | 8.9 | Binding | Guide to Pharmacology | 619 | 10 | 3 | 6 | 5.1 | O=C([C@@H](NC(=O)c1cc2c([nH]1)cccc2)CSc1ncccc1C(=O)O)N1CCN(CC1)C(c1ccccc1)c1ccccc1 | 8730754 | |||
9873836 | 10620 | 0 | None | 1584 | 2 | Rat | 8.9 | pKi | None | 8.9 | Binding | Guide to Pharmacology | 619 | 10 | 3 | 6 | 5.1 | O=C([C@@H](NC(=O)c1cc2c([nH]1)cccc2)CSc1ncccc1C(=O)O)N1CCN(CC1)C(c1ccccc1)c1ccccc1 | 8730754 |