Ligand source activities (1 row/activity)





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DOI

24861391 195530 0 None -2 2 Mouse 9.9 pEC50 = 9.9 Functional
Agonist activity against mouse CCK1 receptorAgonist activity against mouse CCK1 receptor
ChEMBL 578 5 1 7 5.3 O=C(O)c1cc(N2CCN(C(=O)c3cn(-c4ccc5c(c4)OCCO5)c(-c4ccc(F)cc4)n3)CC2)cc2ccccc12 10.1016/j.bmcl.2008.06.057
CHEMBL505225 195530 0 None -2 2 Mouse 9.9 pEC50 = 9.9 Functional
Agonist activity against mouse CCK1 receptorAgonist activity against mouse CCK1 receptor
ChEMBL 578 5 1 7 5.3 O=C(O)c1cc(N2CCN(C(=O)c3cn(-c4ccc5c(c4)OCCO5)c(-c4ccc(F)cc4)n3)CC2)cc2ccccc12 10.1016/j.bmcl.2008.06.057
CHEMBL505969 195530 0 None -2 2 Mouse 9.9 pEC50 = 9.9 Functional
Agonist activity against mouse CCK1 receptorAgonist activity against mouse CCK1 receptor
ChEMBL 578 5 1 7 5.3 O=C(O)c1cc(N2CCN(C(=O)c3cn(-c4ccc5c(c4)OCCO5)c(-c4ccc(F)cc4)n3)CC2)cc2ccccc12 10.1016/j.bmcl.2008.06.057
CHEMBL2369765 216461 14 None - 1 Rat 9.8 pEC50 = 9.8 Functional
Agonist activity at gastrin receptor in rat AR4-2J cells assessed as intracellular calcium mobilization by fluorescence assayAgonist activity at gastrin receptor in rat AR4-2J cells assessed as intracellular calcium mobilization by fluorescence assay
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm101279a
CHEMBL1806528 215753 0 None 13 2 Rat 9.6 pEC50 = 9.6 Functional
Agonist activity at gastrin receptor in rat AR4-2J cells assessed as intracellular calcium mobilization by fluorescence assayAgonist activity at gastrin receptor in rat AR4-2J cells assessed as intracellular calcium mobilization by fluorescence assay
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm101279a
155533399 178624 0 None 2 2 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1838 72 19 24 1.4 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4468861 178624 0 None 2 2 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1838 72 19 24 1.4 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
24861060 195506 0 None -5 3 Mouse 9.5 pEC50 = 9.5 Functional
Agonist activity against mouse CCK1 receptorAgonist activity against mouse CCK1 receptor
ChEMBL 578 7 1 6 6.2 CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2F)c1 10.1016/j.bmcl.2008.06.057
CHEMBL446789 195506 0 None -5 3 Mouse 9.5 pEC50 = 9.5 Functional
Agonist activity against mouse CCK1 receptorAgonist activity against mouse CCK1 receptor
ChEMBL 578 7 1 6 6.2 CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2F)c1 10.1016/j.bmcl.2008.06.057
CHEMBL504861 195506 0 None -5 3 Mouse 9.5 pEC50 = 9.5 Functional
Agonist activity against mouse CCK1 receptorAgonist activity against mouse CCK1 receptor
ChEMBL 578 7 1 6 6.2 CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2F)c1 10.1016/j.bmcl.2008.06.057
155564367 181935 0 None 457 2 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1836 72 18 23 2.9 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4570130 181935 0 None 457 2 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1836 72 18 23 2.9 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
155543846 179991 0 None 14 2 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1838 72 19 24 2.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4522865 179991 0 None 14 2 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1838 72 19 24 2.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/acs.jmedchem.8b01558
56663263 70792 0 None 7 2 Rat 9.5 pEC50 = 9.5 Functional
Agonist activity at gastrin receptor in rat AR4-2J cells assessed as intracellular calcium mobilization by fluorescence assayAgonist activity at gastrin receptor in rat AR4-2J cells assessed as intracellular calcium mobilization by fluorescence assay
ChEMBL 1538 51 14 25 -2.8 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NCCOCCOCCOCCOCCOCCOC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm101279a
CHEMBL1807150 70792 0 None 7 2 Rat 9.5 pEC50 = 9.5 Functional
Agonist activity at gastrin receptor in rat AR4-2J cells assessed as intracellular calcium mobilization by fluorescence assayAgonist activity at gastrin receptor in rat AR4-2J cells assessed as intracellular calcium mobilization by fluorescence assay
ChEMBL 1538 51 14 25 -2.8 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NCCOCCOCCOCCOCCOCCOC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm101279a
155553502 180954 0 None 26 2 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1822 72 19 22 3.0 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OP(=O)(O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4547294 180954 0 None 26 2 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1822 72 19 22 3.0 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OP(=O)(O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
155540415 179718 0 None 1584 2 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1862 71 17 23 3.6 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4516868 179718 0 None 1584 2 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1862 71 17 23 3.6 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
155557285 181297 0 None 295 2 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1779 74 19 22 1.6 CCCC[C@H](NC(=O)[C@H](CNC(=O)CCCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4555341 181297 0 None 295 2 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1779 74 19 22 1.6 CCCC[C@H](NC(=O)[C@H](CNC(=O)CCCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
5311400 10066 1 None - 1 Rat 9.4 pEC50 = 9.4 Functional
Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.
ChEMBL None None None None 10.1021/jm0000416
900 10066 1 None - 1 Rat 9.4 pEC50 = 9.4 Functional
Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.
ChEMBL None None None None 10.1021/jm0000416
CHEMBL262197 10066 1 None - 1 Rat 9.4 pEC50 = 9.4 Functional
Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.
ChEMBL None None None None 10.1021/jm0000416
155559320 181643 0 None -1 2 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1872 72 18 23 3.8 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4563364 181643 0 None -1 2 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1872 72 18 23 3.8 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL1806532 215756 0 None 5 2 Rat 9.4 pEC50 = 9.4 Functional
Agonist activity at gastrin receptor in rat AR4-2J cells assessed as intracellular calcium mobilization by fluorescence assayAgonist activity at gastrin receptor in rat AR4-2J cells assessed as intracellular calcium mobilization by fluorescence assay
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm101279a
155526914 177981 0 None -2 2 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1837 72 19 24 0.8 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4459331 177981 0 None -2 2 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1837 72 19 24 0.8 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
155546692 180421 0 None 3 2 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1861 72 19 23 3.2 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4534236 180421 0 None 3 2 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1861 72 19 23 3.2 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O 10.1021/acs.jmedchem.8b01558
9853654 29561 41 None -1 4 Rat 9.4 pEC50 = 9.4 Functional
Agonist activity at rat CCK2R expressed in rat AR42J cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysisAgonist activity at rat CCK2R expressed in rat AR42J cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysis
ChEMBL 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.0c01233
CHEMBL1328 29561 41 None -1 4 Rat 9.4 pEC50 = 9.4 Functional
Agonist activity at rat CCK2R expressed in rat AR42J cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysisAgonist activity at rat CCK2R expressed in rat AR42J cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysis
ChEMBL 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.0c01233
155516677 176868 0 None -1 2 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1822 72 18 23 2.7 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4443415 176868 0 None -1 2 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1822 72 18 23 2.7 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
155558199 181548 0 None 15488 2 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1894 75 19 24 2.9 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4561184 181548 0 None 15488 2 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1894 75 19 24 2.9 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
155524181 177632 0 None -4 2 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1820 71 18 22 2.7 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4453982 177632 0 None -4 2 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1820 71 18 22 2.7 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
101823779 8178 35 None 354 2 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b01558
16162108 8178 35 None 354 2 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b01558
8408 8178 35 None 354 2 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b01558
CHEMBL4451154 8178 35 None 354 2 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b01558
155555346 181151 0 None -3 2 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1836 71 17 23 2.9 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4551834 181151 0 None -3 2 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1836 71 17 23 2.9 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
4627 7609 50 None -1 6 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b01558
864 7609 50 None -1 6 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b01558
9833444 7609 50 None -1 6 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b01558
CHEMBL1121 7609 50 None -1 6 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b01558
DB09142 7609 50 None -1 6 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b01558
155544674 181715 0 None -1 2 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1822 71 18 23 2.5 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4565336 181715 0 None -1 2 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1822 71 18 23 2.5 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
10509035 21281 0 None - 1 Rat 9.3 pEC50 = 9.3 Functional
Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.
ChEMBL 714 19 7 8 0.3 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CS(=O)(=O)O 10.1021/jm0000416
CHEMBL120150 21281 0 None - 1 Rat 9.3 pEC50 = 9.3 Functional
Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.
ChEMBL 714 19 7 8 0.3 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CS(=O)(=O)O 10.1021/jm0000416
4627 7609 50 None -6 6 Rat 9.2 pEC50 = 9.2 Functional
Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.
ChEMBL None None None None 10.1021/jm0000416
864 7609 50 None -6 6 Rat 9.2 pEC50 = 9.2 Functional
Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.
ChEMBL None None None None 10.1021/jm0000416
9833444 7609 50 None -6 6 Rat 9.2 pEC50 = 9.2 Functional
Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.
ChEMBL None None None None 10.1021/jm0000416
CHEMBL1121 7609 50 None -6 6 Rat 9.2 pEC50 = 9.2 Functional
Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.
ChEMBL None None None None 10.1021/jm0000416
DB09142 7609 50 None -6 6 Rat 9.2 pEC50 = 9.2 Functional
Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.
ChEMBL None None None None 10.1021/jm0000416
4627 7609 50 None -6 6 Rat 9.2 pEC50 = 9.2 Functional
Effective concentration for the stimulation of Inositol Phosphate accumulation in CHO cells expressing wild-type Cholecystokinin type B receptorEffective concentration for the stimulation of Inositol Phosphate accumulation in CHO cells expressing wild-type Cholecystokinin type B receptor
ChEMBL None None None None 10.1021/jm9603072
864 7609 50 None -6 6 Rat 9.2 pEC50 = 9.2 Functional
Effective concentration for the stimulation of Inositol Phosphate accumulation in CHO cells expressing wild-type Cholecystokinin type B receptorEffective concentration for the stimulation of Inositol Phosphate accumulation in CHO cells expressing wild-type Cholecystokinin type B receptor
ChEMBL None None None None 10.1021/jm9603072
9833444 7609 50 None -6 6 Rat 9.2 pEC50 = 9.2 Functional
Effective concentration for the stimulation of Inositol Phosphate accumulation in CHO cells expressing wild-type Cholecystokinin type B receptorEffective concentration for the stimulation of Inositol Phosphate accumulation in CHO cells expressing wild-type Cholecystokinin type B receptor
ChEMBL None None None None 10.1021/jm9603072
CHEMBL1121 7609 50 None -6 6 Rat 9.2 pEC50 = 9.2 Functional
Effective concentration for the stimulation of Inositol Phosphate accumulation in CHO cells expressing wild-type Cholecystokinin type B receptorEffective concentration for the stimulation of Inositol Phosphate accumulation in CHO cells expressing wild-type Cholecystokinin type B receptor
ChEMBL None None None None 10.1021/jm9603072
DB09142 7609 50 None -6 6 Rat 9.2 pEC50 = 9.2 Functional
Effective concentration for the stimulation of Inositol Phosphate accumulation in CHO cells expressing wild-type Cholecystokinin type B receptorEffective concentration for the stimulation of Inositol Phosphate accumulation in CHO cells expressing wild-type Cholecystokinin type B receptor
ChEMBL None None None None 10.1021/jm9603072
155532425 178527 0 None -3 2 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1822 71 18 23 2.5 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)[C@@H](C)CC 10.1021/acs.jmedchem.8b01558
CHEMBL4467338 178527 0 None -3 2 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1822 71 18 23 2.5 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)[C@@H](C)CC 10.1021/acs.jmedchem.8b01558
16755781 195564 12 None -9 3 Mouse 9.1 pEC50 = 9.1 Functional
Agonist activity against mouse CCK1 receptorAgonist activity against mouse CCK1 receptor
ChEMBL 560 7 1 6 6.1 CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 10.1016/j.bmcl.2008.06.057
CHEMBL443189 195564 12 None -9 3 Mouse 9.1 pEC50 = 9.1 Functional
Agonist activity against mouse CCK1 receptorAgonist activity against mouse CCK1 receptor
ChEMBL 560 7 1 6 6.1 CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 10.1016/j.bmcl.2008.06.057
CHEMBL505409 195564 12 None -9 3 Mouse 9.1 pEC50 = 9.1 Functional
Agonist activity against mouse CCK1 receptorAgonist activity against mouse CCK1 receptor
ChEMBL 560 7 1 6 6.1 CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 10.1016/j.bmcl.2008.06.057
CHEMBL505727 195564 12 None -9 3 Mouse 9.1 pEC50 = 9.1 Functional
Agonist activity against mouse CCK1 receptorAgonist activity against mouse CCK1 receptor
ChEMBL 560 7 1 6 6.1 CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 10.1016/j.bmcl.2008.06.057
155517868 176990 0 None 457 2 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1893 76 19 24 3.2 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4445353 176990 0 None 457 2 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1893 76 19 24 3.2 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL64605 222635 7 None 3 4 Rat 9.0 pEC50 = 9 Functional
Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm0000416
162658676 187761 0 None 3 2 Rat 8.9 pEC50 = 8.9 Functional
Agonist activity at rat CCK2R expressed in rat AR42J cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysisAgonist activity at rat CCK2R expressed in rat AR42J cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysis
ChEMBL 1489 37 14 19 -0.7 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 10.1021/acs.jmedchem.0c01233
CHEMBL4758706 187761 0 None 3 2 Rat 8.9 pEC50 = 8.9 Functional
Agonist activity at rat CCK2R expressed in rat AR42J cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysisAgonist activity at rat CCK2R expressed in rat AR42J cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysis
ChEMBL 1489 37 14 19 -0.7 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 10.1021/acs.jmedchem.0c01233
16755781 195564 12 None -9 3 Mouse 8.9 pEC50 = 8.9 Functional
Agonist activity against mouse CCK1 receptorAgonist activity against mouse CCK1 receptor
ChEMBL 560 7 1 6 6.1 CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 10.1016/j.bmcl.2008.06.057
CHEMBL443189 195564 12 None -9 3 Mouse 8.9 pEC50 = 8.9 Functional
Agonist activity against mouse CCK1 receptorAgonist activity against mouse CCK1 receptor
ChEMBL 560 7 1 6 6.1 CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 10.1016/j.bmcl.2008.06.057
CHEMBL505409 195564 12 None -9 3 Mouse 8.9 pEC50 = 8.9 Functional
Agonist activity against mouse CCK1 receptorAgonist activity against mouse CCK1 receptor
ChEMBL 560 7 1 6 6.1 CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 10.1016/j.bmcl.2008.06.057
CHEMBL505727 195564 12 None -9 3 Mouse 8.9 pEC50 = 8.9 Functional
Agonist activity against mouse CCK1 receptorAgonist activity against mouse CCK1 receptor
ChEMBL 560 7 1 6 6.1 CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 10.1016/j.bmcl.2008.06.057
CHEMBL120632 215384 33 None 1 3 Rat 8.9 pEC50 = 8.9 Functional
Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.
ChEMBL None None None CSCC[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm0000416
10372489 11035 0 None - 1 Rat 8.8 pEC50 = 8.8 Functional
Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.
ChEMBL 692 20 7 7 1.3 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCC(=O)O 10.1021/jm0000416
CHEMBL100538 11035 0 None - 1 Rat 8.8 pEC50 = 8.8 Functional
Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.
ChEMBL 692 20 7 7 1.3 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCC(=O)O 10.1021/jm0000416
CHEMBL333477 218171 0 None - 1 Rat 8.8 pEC50 = 8.8 Functional
Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm0000416
24861113 194969 0 None -24 2 Mouse 8.8 pEC50 = 8.8 Functional
Agonist activity against mouse CCK1 receptorAgonist activity against mouse CCK1 receptor
ChEMBL 564 7 1 6 5.9 CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(F)cc2)c1 10.1016/j.bmcl.2008.06.057
CHEMBL498942 194969 0 None -24 2 Mouse 8.8 pEC50 = 8.8 Functional
Agonist activity against mouse CCK1 receptorAgonist activity against mouse CCK1 receptor
ChEMBL 564 7 1 6 5.9 CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(F)cc2)c1 10.1016/j.bmcl.2008.06.057
CHEMBL506201 194969 0 None -24 2 Mouse 8.8 pEC50 = 8.8 Functional
Agonist activity against mouse CCK1 receptorAgonist activity against mouse CCK1 receptor
ChEMBL 564 7 1 6 5.9 CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(F)cc2)c1 10.1016/j.bmcl.2008.06.057
CHEMBL333477 218171 0 None - 1 Rat 8.8 pEC50 = 8.8 Functional
Effective concentration for the stimulation of Inositol Phosphate accumulation in CHO cells expressing wild-type Cholecystokinin type B receptorEffective concentration for the stimulation of Inositol Phosphate accumulation in CHO cells expressing wild-type Cholecystokinin type B receptor
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm9603072
CHEMBL414345 219903 7 None - 1 Human 8.8 pEC50 = 8.8 Functional
Inhibition of (Thr,Nle)-CCK-9 -induced inositol phosphate production in COS-7 cells expressing human CCK2 receptorInhibition of (Thr,Nle)-CCK-9 -induced inositol phosphate production in COS-7 cells expressing human CCK2 receptor
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCN=C(N)N)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm0498755
155535579 178829 0 None -158 2 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1836 71 17 23 2.9 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4471871 178829 0 None -158 2 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1836 71 17 23 2.9 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
10794634 119879 0 None - 1 Rat 8.8 pEC50 = 8.8 Functional
Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.
ChEMBL 677 19 7 7 0.3 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(N)=O 10.1021/jm0000416
CHEMBL331394 119879 0 None - 1 Rat 8.8 pEC50 = 8.8 Functional
Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.
ChEMBL 677 19 7 7 0.3 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(N)=O 10.1021/jm0000416
162673242 189987 0 None 2 2 Rat 8.8 pEC50 = 8.8 Functional
Agonist activity at rat CCK2R expressed in rat AR42J cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysisAgonist activity at rat CCK2R expressed in rat AR42J cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysis
ChEMBL 1475 37 14 19 -1.1 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 10.1021/acs.jmedchem.0c01233
CHEMBL4795913 189987 0 None 2 2 Rat 8.8 pEC50 = 8.8 Functional
Agonist activity at rat CCK2R expressed in rat AR42J cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysisAgonist activity at rat CCK2R expressed in rat AR42J cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysis
ChEMBL 1475 37 14 19 -1.1 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 10.1021/acs.jmedchem.0c01233
155560670 181871 0 None -72 2 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1886 72 17 23 4.2 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4568746 181871 0 None -72 2 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1886 72 17 23 4.2 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O 10.1021/acs.jmedchem.8b01558
162657745 187795 0 None 1 2 Rat 8.7 pEC50 = 8.7 Functional
Agonist activity at rat CCK2R expressed in rat AR42J cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysisAgonist activity at rat CCK2R expressed in rat AR42J cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysis
ChEMBL 1475 37 14 19 -1.1 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 10.1021/acs.jmedchem.0c01233
CHEMBL4759105 187795 0 None 1 2 Rat 8.7 pEC50 = 8.7 Functional
Agonist activity at rat CCK2R expressed in rat AR42J cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysisAgonist activity at rat CCK2R expressed in rat AR42J cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysis
ChEMBL 1475 37 14 19 -1.1 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 10.1021/acs.jmedchem.0c01233
52949124 7663 4 None -2 3 Human 6.0 pEC50 = 6 Functional
Partial agonist activity at wild-type human CCK2R expressed in CHO cells assessed as intracellular calcium response by fluorescence analysisPartial agonist activity at wild-type human CCK2R expressed in CHO cells assessed as intracellular calcium response by fluorescence analysis
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
9055 7663 4 None -2 3 Human 6.0 pEC50 = 6 Functional
Partial agonist activity at wild-type human CCK2R expressed in CHO cells assessed as intracellular calcium response by fluorescence analysisPartial agonist activity at wild-type human CCK2R expressed in CHO cells assessed as intracellular calcium response by fluorescence analysis
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
CHEMBL1269258 7663 4 None -2 3 Human 6.0 pEC50 = 6 Functional
Partial agonist activity at wild-type human CCK2R expressed in CHO cells assessed as intracellular calcium response by fluorescence analysisPartial agonist activity at wild-type human CCK2R expressed in CHO cells assessed as intracellular calcium response by fluorescence analysis
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
DB12694 7663 4 None -2 3 Human 6.0 pEC50 = 6 Functional
Partial agonist activity at wild-type human CCK2R expressed in CHO cells assessed as intracellular calcium response by fluorescence analysisPartial agonist activity at wild-type human CCK2R expressed in CHO cells assessed as intracellular calcium response by fluorescence analysis
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
155539345 179612 0 None -3235 2 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1850 72 16 23 3.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4514283 179612 0 None -3235 2 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1850 72 16 23 3.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL382051 219072 0 None -109 5 Human 7.0 pEC50 = 7.0 Functional
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm050921q
CHEMBL382051 219072 0 None -109 5 Human 7.0 pEC50 = 7.0 Functional
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm050921q
44580899 195854 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Activity at CCK2R-MOPR coexpressed in CHO cells co-transfected with delta-6-Galphaqi4-myr assessed as intracellular calcium release by FLIPRActivity at CCK2R-MOPR coexpressed in CHO cells co-transfected with delta-6-Galphaqi4-myr assessed as intracellular calcium release by FLIPR
ChEMBL 1001 19 8 14 1.1 CN1C(=O)[C@H](NC(=O)Nc2cccc(OCCNC(=O)COCC(=O)NCCNC(=O)COCC(=O)N[C@H]3CC[C@@]4(O)[C@H]5Cc6cc(O)cc7c6[C@@]4(CCN5C)[C@H]3O7)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm800174p
CHEMBL509792 195854 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Activity at CCK2R-MOPR coexpressed in CHO cells co-transfected with delta-6-Galphaqi4-myr assessed as intracellular calcium release by FLIPRActivity at CCK2R-MOPR coexpressed in CHO cells co-transfected with delta-6-Galphaqi4-myr assessed as intracellular calcium release by FLIPR
ChEMBL 1001 19 8 14 1.1 CN1C(=O)[C@H](NC(=O)Nc2cccc(OCCNC(=O)COCC(=O)NCCNC(=O)COCC(=O)N[C@H]3CC[C@@]4(O)[C@H]5Cc6cc(O)cc7c6[C@@]4(CCN5C)[C@H]3O7)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm800174p
CHEMBL414592 219924 0 None -8 2 Human 7.9 pEC50 = 7.9 Functional
In vitro smooth muscle contraction activity in guinea pig stomach consisting of CCK/gastrin receptor subtypeIn vitro smooth muscle contraction activity in guinea pig stomach consisting of CCK/gastrin receptor subtype
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)N(C)C(=O)[C@H](CC(=O)O)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00093a013
162673242 189987 0 None -2 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human CCK2R expressed in human A431 cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysisAgonist activity at human CCK2R expressed in human A431 cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysis
ChEMBL 1475 37 14 19 -1.1 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 10.1021/acs.jmedchem.0c01233
CHEMBL4795913 189987 0 None -2 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human CCK2R expressed in human A431 cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysisAgonist activity at human CCK2R expressed in human A431 cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysis
ChEMBL 1475 37 14 19 -1.1 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 10.1021/acs.jmedchem.0c01233
162658676 187761 0 None -3 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human CCK2R expressed in human A431 cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysisAgonist activity at human CCK2R expressed in human A431 cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysis
ChEMBL 1489 37 14 19 -0.7 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 10.1021/acs.jmedchem.0c01233
CHEMBL4758706 187761 0 None -3 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human CCK2R expressed in human A431 cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysisAgonist activity at human CCK2R expressed in human A431 cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysis
ChEMBL 1489 37 14 19 -0.7 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 10.1021/acs.jmedchem.0c01233
155566319 182519 0 None -4677 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1850 71 16 23 3.2 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4583158 182519 0 None -4677 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1850 71 16 23 3.2 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL64605 222635 7 None -3 4 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at CCKBR in human NCI-H345 cells assessed as calcium releaseAgonist activity at CCKBR in human NCI-H345 cells assessed as calcium release
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.0c00530
CHEMBL409529 219546 2 None -11 2 Human 7.9 pEC50 = 7.9 Functional
In vitro smooth muscle contraction activity in guinea pig stomach consisting of CCK/gastrin receptor subtypeIn vitro smooth muscle contraction activity in guinea pig stomach consisting of CCK/gastrin receptor subtype
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00093a013
155555065 181113 0 None -4168 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1836 71 17 23 2.9 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4550876 181113 0 None -4168 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1836 71 17 23 2.9 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
162657745 187795 0 None -1 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human CCK2R expressed in human A431 cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysisAgonist activity at human CCK2R expressed in human A431 cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysis
ChEMBL 1475 37 14 19 -1.1 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 10.1021/acs.jmedchem.0c01233
CHEMBL4759105 187795 0 None -1 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human CCK2R expressed in human A431 cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysisAgonist activity at human CCK2R expressed in human A431 cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysis
ChEMBL 1475 37 14 19 -1.1 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 10.1021/acs.jmedchem.0c01233
CHEMBL266839 217483 0 None -7 2 Human 6.9 pEC50 = 6.9 Functional
In vitro smooth muscle contraction activity in guinea pig stomach consisting of CCK/gastrin receptor subtypeIn vitro smooth muscle contraction activity in guinea pig stomach consisting of CCK/gastrin receptor subtype
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00093a013
CHEMBL218763 216178 0 None -2 5 Human 7.8 pEC50 = 7.8 Functional
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
162666759 189099 0 None 17 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at CCKBR in human NCI-H345 cells assessed as calcium releaseAgonist activity at CCKBR in human NCI-H345 cells assessed as calcium release
ChEMBL 846 23 9 9 2.9 CC(C)C[C@@H](/C=C/NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)NC(=O)OC(C)(C)C 10.1021/acs.jmedchem.0c00530
CHEMBL4784305 189099 0 None 17 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at CCKBR in human NCI-H345 cells assessed as calcium releaseAgonist activity at CCKBR in human NCI-H345 cells assessed as calcium release
ChEMBL 846 23 9 9 2.9 CC(C)C[C@@H](/C=C/NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)NC(=O)OC(C)(C)C 10.1021/acs.jmedchem.0c00530
155562281 182620 0 None -4168 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1900 71 16 23 4.4 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1cccc2ccccc12)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4585323 182620 0 None -4168 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1900 71 16 23 4.4 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1cccc2ccccc12)C(N)=O 10.1021/acs.jmedchem.8b01558
44418923 168564 0 None -5 5 Human 7.8 pEC50 = 7.8 Functional
Activity at human CCK2 receptor expressed in HEK293 cells assessed as level of [3H]inositol produced relative to controlActivity at human CCK2 receptor expressed in HEK293 cells assessed as level of [3H]inositol produced relative to control
ChEMBL 1132 28 13 13 1.7 CCCC[C@H](NC(=O)[C@@H](Cc1cc2ccccc2[nH]1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061268p
CHEMBL414087 168564 0 None -5 5 Human 7.8 pEC50 = 7.8 Functional
Activity at human CCK2 receptor expressed in HEK293 cells assessed as level of [3H]inositol produced relative to controlActivity at human CCK2 receptor expressed in HEK293 cells assessed as level of [3H]inositol produced relative to control
ChEMBL 1132 28 13 13 1.7 CCCC[C@H](NC(=O)[C@@H](Cc1cc2ccccc2[nH]1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061268p
CHEMBL218763 216178 0 None -2 5 Human 7.8 pEC50 = 7.8 Functional
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
155517761 177002 0 None -416 2 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1900 71 16 23 4.4 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1cccc2ccccc12)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4445529 177002 0 None -416 2 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1900 71 16 23 4.4 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1cccc2ccccc12)C(N)=O 10.1021/acs.jmedchem.8b01558
44346355 164646 0 None - 1 Rat 7.8 pEC50 = 7.8 Functional
Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.
ChEMBL 1260 26 13 15 1.7 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CCCCNC(=O)C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc2ccc(OS(=O)(=O)O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm0000416
CHEMBL408389 164646 0 None - 1 Rat 7.8 pEC50 = 7.8 Functional
Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.
ChEMBL 1260 26 13 15 1.7 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CCCCNC(=O)C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc2ccc(OS(=O)(=O)O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm0000416
155543163 180065 0 None -8709 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1886 72 16 25 2.5 CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4525615 180065 0 None -8709 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1886 72 16 25 2.5 CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL408330 219484 0 None 1 4 Human 7.7 pEC50 = 7.7 Functional
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](CCCC)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
CHEMBL217609 216158 0 None -6 2 Human 7.7 pEC50 = 7.7 Functional
In vitro smooth muscle contraction activity in guinea pig stomach consisting of CCK/gastrin receptor subtypeIn vitro smooth muscle contraction activity in guinea pig stomach consisting of CCK/gastrin receptor subtype
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00093a013
CHEMBL408330 219484 0 None 1 4 Human 7.7 pEC50 = 7.7 Functional
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](CCCC)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
CHEMBL208479 215978 0 None -33 5 Human 5.7 pEC50 = 5.7 Functional
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](CCCC)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm050921q
CHEMBL208479 215978 0 None -33 5 Human 5.7 pEC50 = 5.7 Functional
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](CCCC)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm050921q
10509945 96159 0 None -63 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 896 26 9 9 2.1 CCCC[C@H](NC(=O)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL2369816 96159 0 None -63 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 896 26 9 9 2.1 CCCC[C@H](NC(=O)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL407057 219414 0 None -1 5 Human 4.7 pEC50 = 4.7 Functional
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O 10.1021/jm050921q
10628422 115950 0 None - 1 Rat 8.7 pEC50 = 8.7 Functional
Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.
ChEMBL 692 19 6 8 0.9 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(=O)OC 10.1021/jm0000416
CHEMBL321456 115950 0 None - 1 Rat 8.7 pEC50 = 8.7 Functional
Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.
ChEMBL 692 19 6 8 0.9 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(=O)OC 10.1021/jm0000416
44578767 180295 0 None -3 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity against mouse CCK1 receptorAgonist activity against mouse CCK1 receptor
ChEMBL 517 6 0 6 5.8 CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 10.1016/j.bmcl.2008.06.057
CHEMBL453083 180295 0 None -3 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity against mouse CCK1 receptorAgonist activity against mouse CCK1 receptor
ChEMBL 517 6 0 6 5.8 CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 10.1016/j.bmcl.2008.06.057
CHEMBL503822 180295 0 None -3 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity against mouse CCK1 receptorAgonist activity against mouse CCK1 receptor
ChEMBL 517 6 0 6 5.8 CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 10.1016/j.bmcl.2008.06.057
1647 8095 45 None 2 8 Human 8.6 pEC50 = 8.6 Functional
Activity at CCK2R-MOPR coexpressed in CHO cells co-transfected with delta-6-Galphaqi4-myr assessed as intracellular calcium release by FLIPRActivity at CCK2R-MOPR coexpressed in CHO cells co-transfected with delta-6-Galphaqi4-myr assessed as intracellular calcium release by FLIPR
ChEMBL None None None None 10.1021/jm800174p
5462471 8095 45 None 2 8 Human 8.6 pEC50 = 8.6 Functional
Activity at CCK2R-MOPR coexpressed in CHO cells co-transfected with delta-6-Galphaqi4-myr assessed as intracellular calcium release by FLIPRActivity at CCK2R-MOPR coexpressed in CHO cells co-transfected with delta-6-Galphaqi4-myr assessed as intracellular calcium release by FLIPR
ChEMBL None None None None 10.1021/jm800174p
CHEMBL113995 8095 45 None 2 8 Human 8.6 pEC50 = 8.6 Functional
Activity at CCK2R-MOPR coexpressed in CHO cells co-transfected with delta-6-Galphaqi4-myr assessed as intracellular calcium release by FLIPRActivity at CCK2R-MOPR coexpressed in CHO cells co-transfected with delta-6-Galphaqi4-myr assessed as intracellular calcium release by FLIPR
ChEMBL None None None None 10.1021/jm800174p
CHEMBL38874 8095 45 None 2 8 Human 8.6 pEC50 = 8.6 Functional
Activity at CCK2R-MOPR coexpressed in CHO cells co-transfected with delta-6-Galphaqi4-myr assessed as intracellular calcium release by FLIPRActivity at CCK2R-MOPR coexpressed in CHO cells co-transfected with delta-6-Galphaqi4-myr assessed as intracellular calcium release by FLIPR
ChEMBL None None None None 10.1021/jm800174p
155568312 182857 0 None -36 2 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1836 72 17 23 3.0 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4591101 182857 0 None -36 2 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1836 72 17 23 3.0 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL218327 216173 0 None 2 5 Human 8.6 pEC50 = 8.6 Functional
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
9853654 29561 41 None -9 4 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human CCK2R expressed in human A431 cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysisAgonist activity at human CCK2R expressed in human A431 cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysis
ChEMBL 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.0c01233
CHEMBL1328 29561 41 None -9 4 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human CCK2R expressed in human A431 cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysisAgonist activity at human CCK2R expressed in human A431 cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysis
ChEMBL 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.0c01233
CHEMBL218327 216173 0 None 2 5 Human 8.6 pEC50 = 8.6 Functional
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
44396746 133838 0 None -16 2 Human 5.6 pEC50 = 5.6 Functional
Inhibition of (Thr,Nle)-CCK-9 -induced inositol phosphate production in COS-7 cells expressing human CCK2 receptorInhibition of (Thr,Nle)-CCK-9 -induced inositol phosphate production in COS-7 cells expressing human CCK2 receptor
ChEMBL 637 8 2 6 5.7 C[C@H]1C(=O)N(c2ccc(N(C)C)cc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC3C4CC5CC(C4)CC3C5)C12 10.1021/jm0498755
CHEMBL365620 133838 0 None -16 2 Human 5.6 pEC50 = 5.6 Functional
Inhibition of (Thr,Nle)-CCK-9 -induced inositol phosphate production in COS-7 cells expressing human CCK2 receptorInhibition of (Thr,Nle)-CCK-9 -induced inositol phosphate production in COS-7 cells expressing human CCK2 receptor
ChEMBL 637 8 2 6 5.7 C[C@H]1C(=O)N(c2ccc(N(C)C)cc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC3C4CC5CC(C4)CC3C5)C12 10.1021/jm0498755
155540394 179715 0 None -58 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1820 69 17 23 2.7 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4516794 179715 0 None -58 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1820 69 17 23 2.7 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
4627 7609 50 None -1 6 Human 7.6 pEC50 = 7.6 Functional
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None None 10.1021/jm050921q
864 7609 50 None -1 6 Human 7.6 pEC50 = 7.6 Functional
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None None 10.1021/jm050921q
9833444 7609 50 None -1 6 Human 7.6 pEC50 = 7.6 Functional
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None None 10.1021/jm050921q
CHEMBL1121 7609 50 None -1 6 Human 7.6 pEC50 = 7.6 Functional
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None None 10.1021/jm050921q
DB09142 7609 50 None -1 6 Human 7.6 pEC50 = 7.6 Functional
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None None 10.1021/jm050921q
CHEMBL269185 217559 0 None -5 2 Human 6.6 pEC50 = 6.6 Functional
In vitro smooth muscle contraction activity in guinea pig stomach consisting of CCK/gastrin receptor subtypeIn vitro smooth muscle contraction activity in guinea pig stomach consisting of CCK/gastrin receptor subtype
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(C)=O)C(=O)NCC(=O)N(C)[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00093a013
CHEMBL375360 218997 4 None 1 2 Human 7.6 pEC50 = 7.6 Functional
Activity at human CCK2 receptor expressed in HEK293 cells assessed as level of [3H]inositol produced relative to controlActivity at human CCK2 receptor expressed in HEK293 cells assessed as level of [3H]inositol produced relative to control
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm061268p
4627 7609 50 None -1 6 Human 7.6 pEC50 = 7.6 Functional
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None None 10.1021/jm050921q
864 7609 50 None -1 6 Human 7.6 pEC50 = 7.6 Functional
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None None 10.1021/jm050921q
9833444 7609 50 None -1 6 Human 7.6 pEC50 = 7.6 Functional
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None None 10.1021/jm050921q
CHEMBL1121 7609 50 None -1 6 Human 7.6 pEC50 = 7.6 Functional
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None None 10.1021/jm050921q
DB09142 7609 50 None -1 6 Human 7.6 pEC50 = 7.6 Functional
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None None 10.1021/jm050921q
52949124 7663 4 None -2 3 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human CCK2R V6.51I, Y6.52F mutant expressed in CHO cells assessed as intracellular calcium response by fluorescence analysisAgonist activity at human CCK2R V6.51I, Y6.52F mutant expressed in CHO cells assessed as intracellular calcium response by fluorescence analysis
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
9055 7663 4 None -2 3 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human CCK2R V6.51I, Y6.52F mutant expressed in CHO cells assessed as intracellular calcium response by fluorescence analysisAgonist activity at human CCK2R V6.51I, Y6.52F mutant expressed in CHO cells assessed as intracellular calcium response by fluorescence analysis
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
CHEMBL1269258 7663 4 None -2 3 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human CCK2R V6.51I, Y6.52F mutant expressed in CHO cells assessed as intracellular calcium response by fluorescence analysisAgonist activity at human CCK2R V6.51I, Y6.52F mutant expressed in CHO cells assessed as intracellular calcium response by fluorescence analysis
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
DB12694 7663 4 None -2 3 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human CCK2R V6.51I, Y6.52F mutant expressed in CHO cells assessed as intracellular calcium response by fluorescence analysisAgonist activity at human CCK2R V6.51I, Y6.52F mutant expressed in CHO cells assessed as intracellular calcium response by fluorescence analysis
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
10723875 21714 0 None - 1 Rat 8.5 pEC50 = 8.5 Functional
Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.
ChEMBL 767 21 7 7 2.1 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(=O)NCc1ccccc1 10.1021/jm0000416
CHEMBL120827 21714 0 None - 1 Rat 8.5 pEC50 = 8.5 Functional
Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.
ChEMBL 767 21 7 7 2.1 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(=O)NCc1ccccc1 10.1021/jm0000416
CHEMBL411271 219654 0 None - 1 Rat 8.5 pEC50 = 8.5 Functional
Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm0000416
CHEMBL336381 218362 0 None 2 4 Human 7.5 pEC50 = 7.5 Functional
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
155540739 179286 0 None -3388 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1907 74 17 24 2.5 CCCC[C@H](NC(=O)[C@H](Cc1cc2ccccc2[nH]1)NC(=O)CNC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(C)=O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4483457 179286 0 None -3388 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1907 74 17 24 2.5 CCCC[C@H](NC(=O)[C@H](Cc1cc2ccccc2[nH]1)NC(=O)CNC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(C)=O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL336381 218362 0 None 2 4 Human 7.5 pEC50 = 7.5 Functional
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
CHEMBL383458 219092 0 None -1 5 Human 6.5 pEC50 = 6.5 Functional
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None CCCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm050921q
CHEMBL383458 219092 0 None -1 5 Human 6.5 pEC50 = 6.5 Functional
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None CCCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm050921q
CHEMBL205965 215948 0 None 42 5 Human 7.4 pEC50 = 7.4 Functional
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
CHEMBL205965 215948 0 None 42 5 Human 7.4 pEC50 = 7.4 Functional
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
73347063 96229 0 None - 1 Rat 8.4 pEC50 = 8.4 Functional
Effective concentration for the stimulation of Inositol Phosphate accumulation in CHO cells expressing wild-type Cholecystokinin type B receptorEffective concentration for the stimulation of Inositol Phosphate accumulation in CHO cells expressing wild-type Cholecystokinin type B receptor
ChEMBL 674 11 7 6 2.4 C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCCCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm9603072
CHEMBL2371221 96229 0 None - 1 Rat 8.4 pEC50 = 8.4 Functional
Effective concentration for the stimulation of Inositol Phosphate accumulation in CHO cells expressing wild-type Cholecystokinin type B receptorEffective concentration for the stimulation of Inositol Phosphate accumulation in CHO cells expressing wild-type Cholecystokinin type B receptor
ChEMBL 674 11 7 6 2.4 C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCCCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm9603072
CHEMBL382349 219081 0 None 14 5 Human 8.3 pEC50 = 8.3 Functional
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
44418924 163661 0 None -8 5 Human 8.3 pEC50 = 8.3 Functional
Activity at human CCK2 receptor expressed in HEK293 cells assessed as level of [3H]inositol produced relative to controlActivity at human CCK2 receptor expressed in HEK293 cells assessed as level of [3H]inositol produced relative to control
ChEMBL 1031 27 13 12 0.2 CCCC[C@H](NC(=O)[C@H](N)Cc1cc2ccccc2[nH]1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061268p
CHEMBL407198 163661 0 None -8 5 Human 8.3 pEC50 = 8.3 Functional
Activity at human CCK2 receptor expressed in HEK293 cells assessed as level of [3H]inositol produced relative to controlActivity at human CCK2 receptor expressed in HEK293 cells assessed as level of [3H]inositol produced relative to control
ChEMBL 1031 27 13 12 0.2 CCCC[C@H](NC(=O)[C@H](N)Cc1cc2ccccc2[nH]1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061268p
CHEMBL382349 219081 0 None 14 5 Human 8.3 pEC50 = 8.3 Functional
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
162672110 189639 0 None 39 2 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at CCKBR in human NCI-H345 cells assessed as calcium releaseAgonist activity at CCKBR in human NCI-H345 cells assessed as calcium release
ChEMBL 848 22 9 9 2.0 CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.0c00530
CHEMBL4791620 189639 0 None 39 2 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at CCKBR in human NCI-H345 cells assessed as calcium releaseAgonist activity at CCKBR in human NCI-H345 cells assessed as calcium release
ChEMBL 848 22 9 9 2.0 CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.0c00530
155535107 178793 0 None -323 2 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1904 73 19 22 4.7 CCCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4471525 178793 0 None -323 2 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1904 73 19 22 4.7 CCCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
155531277 178410 0 None -2 2 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1821 72 18 23 2.1 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4465747 178410 0 None -2 2 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1821 72 18 23 2.1 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
44396745 131816 0 None -4 2 Human 6.3 pEC50 = 6.3 Functional
Inhibition of (Thr,Nle)-CCK-9 -induced inositol phosphate production in COS-7 cells expressing human CCK2 receptorInhibition of (Thr,Nle)-CCK-9 -induced inositol phosphate production in COS-7 cells expressing human CCK2 receptor
ChEMBL 623 8 2 6 5.5 CN(C)c1ccc(N2C(=O)CC3[C@H](N[C@@H](Cc4c[nH]c5ccccc45)C(=O)OC4C5CC6CC(C5)CC4C6)CCCN3C2=O)cc1 10.1021/jm0498755
CHEMBL364334 131816 0 None -4 2 Human 6.3 pEC50 = 6.3 Functional
Inhibition of (Thr,Nle)-CCK-9 -induced inositol phosphate production in COS-7 cells expressing human CCK2 receptorInhibition of (Thr,Nle)-CCK-9 -induced inositol phosphate production in COS-7 cells expressing human CCK2 receptor
ChEMBL 623 8 2 6 5.5 CN(C)c1ccc(N2C(=O)CC3[C@H](N[C@@H](Cc4c[nH]c5ccccc45)C(=O)OC4C5CC6CC(C5)CC4C6)CCCN3C2=O)cc1 10.1021/jm0498755
CHEMBL2370248 216593 0 None 1 2 Human 7.3 pEC50 = 7.3 Functional
In vitro smooth muscle contraction activity in guinea pig stomach consisting of CCK/gastrin receptor subtypeIn vitro smooth muscle contraction activity in guinea pig stomach consisting of CCK/gastrin receptor subtype
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00093a013
44580932 180249 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Activity at CCK2R-MOPR coexpressed in CHO cells co-transfected with delta-6-Galphaqi4-myr assessed as intracellular calcium release by FLIPRActivity at CCK2R-MOPR coexpressed in CHO cells co-transfected with delta-6-Galphaqi4-myr assessed as intracellular calcium release by FLIPR
ChEMBL 617 14 6 10 -1.5 CNC(=O)COCC(=O)NCCCCNC(=O)COCC(=O)N[C@H]1CC[C@@]2(O)[C@H]3Cc4cc(O)cc5c4[C@@]2(CCN3C)[C@H]1O5 10.1021/jm800174p
CHEMBL452991 180249 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Activity at CCK2R-MOPR coexpressed in CHO cells co-transfected with delta-6-Galphaqi4-myr assessed as intracellular calcium release by FLIPRActivity at CCK2R-MOPR coexpressed in CHO cells co-transfected with delta-6-Galphaqi4-myr assessed as intracellular calcium release by FLIPR
ChEMBL 617 14 6 10 -1.5 CNC(=O)COCC(=O)NCCCCNC(=O)COCC(=O)N[C@H]1CC[C@@]2(O)[C@H]3Cc4cc(O)cc5c4[C@@]2(CCN3C)[C@H]1O5 10.1021/jm800174p
52949124 7663 4 None -2 3 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human CCK2R H7.39L mutant expressed in CHO cells assessed as intracellular calcium response by fluorescence analysisAgonist activity at human CCK2R H7.39L mutant expressed in CHO cells assessed as intracellular calcium response by fluorescence analysis
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
9055 7663 4 None -2 3 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human CCK2R H7.39L mutant expressed in CHO cells assessed as intracellular calcium response by fluorescence analysisAgonist activity at human CCK2R H7.39L mutant expressed in CHO cells assessed as intracellular calcium response by fluorescence analysis
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
CHEMBL1269258 7663 4 None -2 3 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human CCK2R H7.39L mutant expressed in CHO cells assessed as intracellular calcium response by fluorescence analysisAgonist activity at human CCK2R H7.39L mutant expressed in CHO cells assessed as intracellular calcium response by fluorescence analysis
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
DB12694 7663 4 None -2 3 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human CCK2R H7.39L mutant expressed in CHO cells assessed as intracellular calcium response by fluorescence analysisAgonist activity at human CCK2R H7.39L mutant expressed in CHO cells assessed as intracellular calcium response by fluorescence analysis
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
CHEMBL386682 219166 0 None -60 2 Human 8.2 pEC50 = 8.2 Functional
In vitro smooth muscle contraction activity in guinea pig stomach consisting of CCK/gastrin receptor subtypeIn vitro smooth muscle contraction activity in guinea pig stomach consisting of CCK/gastrin receptor subtype
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN(C)C(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00093a013
CHEMBL206974 215961 0 None 2 5 Human 8.2 pEC50 = 8.2 Functional
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
CHEMBL206974 215961 0 None 2 5 Human 8.2 pEC50 = 8.2 Functional
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
44387568 68981 0 None - 1 Rat 8.2 pEC50 = 8.2 Functional
Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.
ChEMBL 660 11 7 6 2.0 C[C@@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm0000416
CHEMBL177799 68981 0 None - 1 Rat 8.2 pEC50 = 8.2 Functional
Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.
ChEMBL 660 11 7 6 2.0 C[C@@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm0000416
10327028 96230 0 None - 1 Rat 8.2 pEC50 = 8.2 Functional
Effective concentration for the stimulation of Inositol Phosphate accumulation in CHO cells expressing wild-type Cholecystokinin type B receptorEffective concentration for the stimulation of Inositol Phosphate accumulation in CHO cells expressing wild-type Cholecystokinin type B receptor
ChEMBL 660 11 7 6 2.0 C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm9603072
CHEMBL2371222 96230 0 None - 1 Rat 8.2 pEC50 = 8.2 Functional
Effective concentration for the stimulation of Inositol Phosphate accumulation in CHO cells expressing wild-type Cholecystokinin type B receptorEffective concentration for the stimulation of Inositol Phosphate accumulation in CHO cells expressing wild-type Cholecystokinin type B receptor
ChEMBL 660 11 7 6 2.0 C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm9603072
10439779 113463 0 None - 1 Rat 8.2 pEC50 = 8.2 Functional
Effective concentration for the stimulation of Inositol Phosphate accumulation in CHO cells expressing wild-type Cholecystokinin type B receptorEffective concentration for the stimulation of Inositol Phosphate accumulation in CHO cells expressing wild-type Cholecystokinin type B receptor
ChEMBL 710 11 7 8 2.2 C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCSSCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm9603072
CHEMBL3143501 113463 0 None - 1 Rat 8.2 pEC50 = 8.2 Functional
Effective concentration for the stimulation of Inositol Phosphate accumulation in CHO cells expressing wild-type Cholecystokinin type B receptorEffective concentration for the stimulation of Inositol Phosphate accumulation in CHO cells expressing wild-type Cholecystokinin type B receptor
ChEMBL 710 11 7 8 2.2 C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCSSCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm9603072
CHEMBL262172 217307 0 None -19 5 Human 8.1 pEC50 = 8.1 Functional
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm050921q
CHEMBL262172 217307 0 None -19 5 Human 8.1 pEC50 = 8.1 Functional
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm050921q
155535249 178782 0 None -2754 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1808 68 16 23 2.0 CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4471373 178782 0 None -2754 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1808 68 16 23 2.0 CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
155515427 176728 0 None -1819 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1886 72 17 23 4.2 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4441596 176728 0 None -1819 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1886 72 17 23 4.2 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL217236 216151 0 None -4 2 Human 8.1 pEC50 = 8.1 Functional
In vitro smooth muscle contraction activity in guinea pig stomach consisting of CCK/gastrin receptor subtypeIn vitro smooth muscle contraction activity in guinea pig stomach consisting of CCK/gastrin receptor subtype
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00093a013
52949124 7663 4 None -2 3 Human 6.0 pEC50 = 6.0 Functional
Partial agonist activity at wild-type human CCK2R expressed in CHO cells assessed as intracellular calcium response by fluorescence analysisPartial agonist activity at wild-type human CCK2R expressed in CHO cells assessed as intracellular calcium response by fluorescence analysis
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
9055 7663 4 None -2 3 Human 6.0 pEC50 = 6.0 Functional
Partial agonist activity at wild-type human CCK2R expressed in CHO cells assessed as intracellular calcium response by fluorescence analysisPartial agonist activity at wild-type human CCK2R expressed in CHO cells assessed as intracellular calcium response by fluorescence analysis
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
CHEMBL1269258 7663 4 None -2 3 Human 6.0 pEC50 = 6.0 Functional
Partial agonist activity at wild-type human CCK2R expressed in CHO cells assessed as intracellular calcium response by fluorescence analysisPartial agonist activity at wild-type human CCK2R expressed in CHO cells assessed as intracellular calcium response by fluorescence analysis
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
DB12694 7663 4 None -2 3 Human 6.0 pEC50 = 6.0 Functional
Partial agonist activity at wild-type human CCK2R expressed in CHO cells assessed as intracellular calcium response by fluorescence analysisPartial agonist activity at wild-type human CCK2R expressed in CHO cells assessed as intracellular calcium response by fluorescence analysis
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
44396655 128828 0 None 3 2 Human 7.0 pEC50 = 7.0 Functional
Inhibition of (Thr,Nle)-CCK-9 -induced inositol phosphate production in COS-7 cells expressing human CCK2 receptorInhibition of (Thr,Nle)-CCK-9 -induced inositol phosphate production in COS-7 cells expressing human CCK2 receptor
ChEMBL 608 8 2 5 5.7 C[C@H]1C(=O)N(Cc2ccccc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC3C4CC5CC(C4)CC3C5)C12 10.1021/jm0498755
CHEMBL359589 128828 0 None 3 2 Human 7.0 pEC50 = 7.0 Functional
Inhibition of (Thr,Nle)-CCK-9 -induced inositol phosphate production in COS-7 cells expressing human CCK2 receptorInhibition of (Thr,Nle)-CCK-9 -induced inositol phosphate production in COS-7 cells expressing human CCK2 receptor
ChEMBL 608 8 2 5 5.7 C[C@H]1C(=O)N(Cc2ccccc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC3C4CC5CC(C4)CC3C5)C12 10.1021/jm0498755
45113249 12261 0 None - 1 Human 8.5 pED50 = 8.5 Functional
Agonist activity at human CCK2 receptor expressed in COS7 cells assessed as stimulation of [3H]inositol phosphate formationAgonist activity at human CCK2 receptor expressed in COS7 cells assessed as stimulation of [3H]inositol phosphate formation
ChEMBL 1259 33 13 12 5.4 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)CCNC(=S)Nc1ccc(O)c(NC(=O)CNC(=O)CSC(c2ccccc2)(c2ccccc2)c2ccccc2)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.ejmech.2009.09.043
CHEMBL1076229 12261 0 None - 1 Human 8.5 pED50 = 8.5 Functional
Agonist activity at human CCK2 receptor expressed in COS7 cells assessed as stimulation of [3H]inositol phosphate formationAgonist activity at human CCK2 receptor expressed in COS7 cells assessed as stimulation of [3H]inositol phosphate formation
ChEMBL 1259 33 13 12 5.4 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)CCNC(=S)Nc1ccc(O)c(NC(=O)CNC(=O)CSC(c2ccccc2)(c2ccccc2)c2ccccc2)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.ejmech.2009.09.043
45113375 12263 0 None - 1 Human 8.3 pED50 = 8.3 Functional
Agonist activity at human CCK2 receptor expressed in COS7 cells assessed as stimulation of [3H]inositol phosphate formationAgonist activity at human CCK2 receptor expressed in COS7 cells assessed as stimulation of [3H]inositol phosphate formation
ChEMBL 1344 39 13 12 7.8 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCCNC(=O)CCCCCNC(=S)Nc1ccc(O)c(NC(=O)CNC(=O)CSC(c2ccccc2)(c2ccccc2)c2ccccc2)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.ejmech.2009.09.043
CHEMBL1076232 12263 0 None - 1 Human 8.3 pED50 = 8.3 Functional
Agonist activity at human CCK2 receptor expressed in COS7 cells assessed as stimulation of [3H]inositol phosphate formationAgonist activity at human CCK2 receptor expressed in COS7 cells assessed as stimulation of [3H]inositol phosphate formation
ChEMBL 1344 39 13 12 7.8 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCCNC(=O)CCCCCNC(=S)Nc1ccc(O)c(NC(=O)CNC(=O)CSC(c2ccccc2)(c2ccccc2)c2ccccc2)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.ejmech.2009.09.043
46879513 12262 0 None - 1 Human 7.1 pED50 = 7.1 Functional
Agonist activity at human CCK2 receptor expressed in COS7 cells assessed as stimulation of [3H]inositol phosphate formationAgonist activity at human CCK2 receptor expressed in COS7 cells assessed as stimulation of [3H]inositol phosphate formation
ChEMBL 1118 27 11 10 7.0 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=S)Nc1ccc(O)c(NC(=O)CNC(=O)CSC(c2ccccc2)(c2ccccc2)c2ccccc2)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.ejmech.2009.09.043
CHEMBL1076230 12262 0 None - 1 Human 7.1 pED50 = 7.1 Functional
Agonist activity at human CCK2 receptor expressed in COS7 cells assessed as stimulation of [3H]inositol phosphate formationAgonist activity at human CCK2 receptor expressed in COS7 cells assessed as stimulation of [3H]inositol phosphate formation
ChEMBL 1118 27 11 10 7.0 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=S)Nc1ccc(O)c(NC(=O)CNC(=O)CSC(c2ccccc2)(c2ccccc2)c2ccccc2)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.ejmech.2009.09.043
70697518 84581 0 None -1 2 Human 4.0 pIC50 = 4 Functional
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 367 3 2 3 4.4 O=C1Nc2ccccc2C(c2ccccc2)=NC1C[C@@H]1CNc2ccccc21 10.1021/jm00390a019
CHEMBL2092748 84581 0 None -1 2 Human 4.0 pIC50 = 4 Functional
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 367 3 2 3 4.4 O=C1Nc2ccccc2C(c2ccccc2)=NC1C[C@@H]1CNc2ccccc21 10.1021/jm00390a019
44281084 119469 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 497 8 3 4 3.3 O=C(O)CNC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL33043 119469 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 497 8 3 4 3.3 O=C(O)CNC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
44280368 103672 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 573 8 2 4 5.4 CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)c1ccc(C(=O)O)cc1 10.1021/jm950372w
CHEMBL265740 103672 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 573 8 2 4 5.4 CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)c1ccc(C(=O)O)cc1 10.1021/jm950372w
44280992 106895 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 678 12 4 5 5.5 CC1(C)CCC(NC(=O)[C@@H](CCC(=O)O)NC(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCC3)CC2)CC1 10.1021/jm950372w
CHEMBL287564 106895 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 678 12 4 5 5.5 CC1(C)CCC(NC(=O)[C@@H](CCC(=O)O)NC(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCC3)CC2)CC1 10.1021/jm950372w
44280620 110693 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 686 15 4 5 5.2 O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NCCCc1ccccc1 10.1021/jm950372w
CHEMBL30924 110693 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 686 15 4 5 5.2 O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NCCCc1ccccc1 10.1021/jm950372w
44280113 175009 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 684 12 4 5 5.5 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1ccc2c(c1)CCC2 10.1021/jm950372w
CHEMBL433623 175009 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 684 12 4 5 5.5 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1ccc2c(c1)CCC2 10.1021/jm950372w
44280895 174875 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 652 15 3 5 5.1 CCCN(CCC)C(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL432679 174875 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 652 15 3 5 5.1 CCCN(CCC)C(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
44212546 106704 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 626 10 4 4 5.3 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm950372w
CHEMBL286228 106704 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 626 10 4 4 5.3 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm950372w
44280314 176473 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 694 12 4 5 6.2 O=C(CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O)Nc1cccc2ccccc12 10.1021/jm950372w
CHEMBL443781 176473 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 694 12 4 5 6.2 O=C(CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O)Nc1cccc2ccccc12 10.1021/jm950372w
13822916 196505 0 None -39 3 Human 4.9 pIC50 = 4.9 Functional
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 421 3 1 4 5.3 Cc1nnc2n1-c1ccccc1C(c1ccccc1F)=N[C@@H]2Cc1c[nH]c2ccccc12 10.1021/jm00390a019
CHEMBL51569 196505 0 None -39 3 Human 4.9 pIC50 = 4.9 Functional
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 421 3 1 4 5.3 Cc1nnc2n1-c1ccccc1C(c1ccccc1F)=N[C@@H]2Cc1c[nH]c2ccccc12 10.1021/jm00390a019
65987 106353 13 None 10 2 Human 5.9 pIC50 = 5.9 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 440 6 2 3 4.1 O=C(O)CC[C@@H](NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL283820 106353 13 None 10 2 Human 5.9 pIC50 = 5.9 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 440 6 2 3 4.1 O=C(O)CC[C@@H](NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
44280179 109798 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 601 11 3 4 5.3 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(CCc1ccccc1)C(=O)O 10.1021/jm950372w
CHEMBL30696 109798 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 601 11 3 4 5.3 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(CCc1ccccc1)C(=O)O 10.1021/jm950372w
44280090 106312 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 640 11 4 4 5.7 O=C(O)CC(Cc1c[nH]c2ccccc12)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL283460 106312 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 640 11 4 4 5.7 O=C(O)CC(Cc1c[nH]c2ccccc12)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
44280245 106811 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 708 12 3 5 6.2 CN(C(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)c1cccc2ccccc12 10.1021/jm950372w
CHEMBL286941 106811 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 708 12 3 5 6.2 CN(C(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)c1cccc2ccccc12 10.1021/jm950372w
656755 74484 32 None -1 2 Human 4.9 pIC50 = 4.9 Functional
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 397 3 1 2 4.7 CN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00390a019
CHEMBL1907717 74484 32 None -1 2 Human 4.9 pIC50 = 4.9 Functional
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 397 3 1 2 4.7 CN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00390a019
15167802 74486 0 None 2 2 Human 4.9 pIC50 = 4.9 Functional
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 436 5 1 3 5.0 N#CCCN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00390a019
CHEMBL1907720 74486 0 None 2 2 Human 4.9 pIC50 = 4.9 Functional
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 436 5 1 3 5.0 N#CCCN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00390a019
15614841 74495 0 None 6 2 Human 4.9 pIC50 = 4.9 Functional
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 390 5 1 3 4.7 O=C1Nc2ccc(Cl)cc2C(c2ccccc2)=N[C@@H]1COCc1ccccc1 10.1021/jm00390a019
CHEMBL1907734 74495 0 None 6 2 Human 4.9 pIC50 = 4.9 Functional
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 390 5 1 3 4.7 O=C1Nc2ccc(Cl)cc2C(c2ccccc2)=N[C@@H]1COCc1ccccc1 10.1021/jm00390a019
15614739 82195 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 350 3 1 3 4.3 O=C1Nc2ccccc2C(c2ccccc2F)=NC1Cc1ccsc1 10.1021/jm00390a019
CHEMBL20408 82195 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 350 3 1 3 4.3 O=C1Nc2ccccc2C(c2ccccc2F)=NC1Cc1ccsc1 10.1021/jm00390a019
20063212 173920 0 None 3 2 Human 4.9 pIC50 = 4.9 Functional
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 395 3 0 3 4.5 CN1CC(CC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c2ccccc21 10.1021/jm00390a019
CHEMBL429063 173920 0 None 3 2 Human 4.9 pIC50 = 4.9 Functional
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 395 3 0 3 4.5 CN1CC(CC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c2ccccc21 10.1021/jm00390a019
44279853 111570 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 593 10 3 4 5.6 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](CC1CCCCC1)C(=O)O 10.1021/jm950372w
CHEMBL31093 111570 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 593 10 3 4 5.6 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](CC1CCCCC1)C(=O)O 10.1021/jm950372w
44418923 168564 0 None -5 5 Human 7.8 pIC50 = 7.8 Functional
Activity at human CCK2 receptor expressed in HEK293 cells assessed as level of [3H]inositol produced relative to controlActivity at human CCK2 receptor expressed in HEK293 cells assessed as level of [3H]inositol produced relative to control
ChEMBL 1132 28 13 13 1.7 CCCC[C@H](NC(=O)[C@@H](Cc1cc2ccccc2[nH]1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061268p
CHEMBL414087 168564 0 None -5 5 Human 7.8 pIC50 = 7.8 Functional
Activity at human CCK2 receptor expressed in HEK293 cells assessed as level of [3H]inositol produced relative to controlActivity at human CCK2 receptor expressed in HEK293 cells assessed as level of [3H]inositol produced relative to control
ChEMBL 1132 28 13 13 1.7 CCCC[C@H](NC(=O)[C@@H](Cc1cc2ccccc2[nH]1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061268p
44280622 125992 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 698 12 4 5 5.9 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2c1CCCC2 10.1021/jm950372w
CHEMBL34332 125992 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 698 12 4 5 5.9 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2c1CCCC2 10.1021/jm950372w
44280374 109644 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 559 8 3 4 5.4 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)Nc1cccc(C(=O)O)c1 10.1021/jm950372w
CHEMBL30575 109644 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 559 8 3 4 5.4 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)Nc1cccc(C(=O)O)c1 10.1021/jm950372w
44280510 109732 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 621 10 3 4 5.5 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(Cc1ccc(Cl)cc1)C(=O)O 10.1021/jm950372w
CHEMBL30639 109732 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 621 10 3 4 5.5 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(Cc1ccc(Cl)cc1)C(=O)O 10.1021/jm950372w
44280406 126304 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 658 12 3 5 5.1 CN(C(=O)[C@@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)c1ccccc1 10.1021/jm950372w
CHEMBL34569 126304 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 658 12 3 5 5.1 CN(C(=O)[C@@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)c1ccccc1 10.1021/jm950372w
44280598 107269 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 694 12 4 5 6.2 O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2ccccc12 10.1021/jm950372w
CHEMBL291001 107269 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 694 12 4 5 6.2 O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2ccccc12 10.1021/jm950372w
44280399 109872 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 603 10 4 5 4.6 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(Cc1ccc(O)cc1)C(=O)O 10.1021/jm950372w
CHEMBL30756 109872 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 603 10 4 5 4.6 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(Cc1ccc(O)cc1)C(=O)O 10.1021/jm950372w
44396655 128828 0 None 3 2 Human 5.8 pIC50 = 5.8 Functional
Inhibition of (Thr,Nle)-CCK-9-induced inositol phosphate production in COS-7 cells expressing human CCK2 receptorInhibition of (Thr,Nle)-CCK-9-induced inositol phosphate production in COS-7 cells expressing human CCK2 receptor
ChEMBL 608 8 2 5 5.7 C[C@H]1C(=O)N(Cc2ccccc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC3C4CC5CC(C4)CC3C5)C12 10.1021/jm0498755
CHEMBL359589 128828 0 None 3 2 Human 5.8 pIC50 = 5.8 Functional
Inhibition of (Thr,Nle)-CCK-9-induced inositol phosphate production in COS-7 cells expressing human CCK2 receptorInhibition of (Thr,Nle)-CCK-9-induced inositol phosphate production in COS-7 cells expressing human CCK2 receptor
ChEMBL 608 8 2 5 5.7 C[C@H]1C(=O)N(Cc2ccccc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC3C4CC5CC(C4)CC3C5)C12 10.1021/jm0498755
70697534 84622 0 None 1 2 Human 4.8 pIC50 = 4.8 Functional
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 367 3 2 3 4.4 O=C1Nc2ccccc2C(c2ccccc2)=NC1C[C@H]1CNc2ccccc21 10.1021/jm00390a019
CHEMBL2092989 84622 0 None 1 2 Human 4.8 pIC50 = 4.8 Functional
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 367 3 2 3 4.4 O=C1Nc2ccccc2C(c2ccccc2)=NC1C[C@H]1CNc2ccccc21 10.1021/jm00390a019
44280131 106368 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 680 11 4 5 5.8 O=C(O)C[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2ccccc12 10.1021/jm950372w
CHEMBL283914 106368 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 680 11 4 5 5.8 O=C(O)C[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2ccccc12 10.1021/jm950372w
44280177 106265 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 601 11 3 4 5.3 O=C(O)C[C@H](Cc1ccccc1)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL283204 106265 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 601 11 3 4 5.3 O=C(O)C[C@H](Cc1ccccc1)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
5311201 214174 35 None 1 7 Human 8.7 pIC50 = 8.7 Functional
Antagonistic activity against cholecystokinin type B receptorAntagonistic activity against cholecystokinin type B receptor
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00067a001
CHEMBL9387 214174 35 None 1 7 Human 8.7 pIC50 = 8.7 Functional
Antagonistic activity against cholecystokinin type B receptorAntagonistic activity against cholecystokinin type B receptor
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00067a001
44280915 107055 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 676 10 3 5 5.2 O=C(O)C[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL289008 107055 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 676 10 3 5 5.2 O=C(O)C[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
44279852 106138 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 690 11 3 5 5.6 O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL282476 106138 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 690 11 3 5 5.6 O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
15167824 74493 0 None -2 2 Human 4.7 pIC50 = 4.7 Functional
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 379 3 1 2 4.6 CN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2)c2ccccc21 10.1021/jm00390a019
CHEMBL1907731 74493 0 None -2 2 Human 4.7 pIC50 = 4.7 Functional
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 379 3 1 2 4.6 CN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2)c2ccccc21 10.1021/jm00390a019
44396746 133838 0 None -16 2 Human 5.7 pIC50 = 5.7 Functional
Inhibition of (Thr,Nle)-CCK-9-induced inositol phosphate production in COS-7 cells expressing human CCK2 receptorInhibition of (Thr,Nle)-CCK-9-induced inositol phosphate production in COS-7 cells expressing human CCK2 receptor
ChEMBL 637 8 2 6 5.7 C[C@H]1C(=O)N(c2ccc(N(C)C)cc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC3C4CC5CC(C4)CC3C5)C12 10.1021/jm0498755
CHEMBL365620 133838 0 None -16 2 Human 5.7 pIC50 = 5.7 Functional
Inhibition of (Thr,Nle)-CCK-9-induced inositol phosphate production in COS-7 cells expressing human CCK2 receptorInhibition of (Thr,Nle)-CCK-9-induced inositol phosphate production in COS-7 cells expressing human CCK2 receptor
ChEMBL 637 8 2 6 5.7 C[C@H]1C(=O)N(c2ccc(N(C)C)cc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC3C4CC5CC(C4)CC3C5)C12 10.1021/jm0498755
44351469 123713 0 None - 1 Rat 6.7 pIC50 = 6.7 Functional
Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)
ChEMBL 603 7 3 4 6.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1CC(c2ccc(Cl)cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL338526 123713 0 None - 1 Rat 6.7 pIC50 = 6.7 Functional
Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)
ChEMBL 603 7 3 4 6.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1CC(c2ccc(Cl)cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
44280316 103539 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 680 11 4 5 5.8 O=C(C[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O)Nc1cccc2ccccc12 10.1021/jm950372w
CHEMBL264606 103539 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 680 11 4 5 5.8 O=C(C[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O)Nc1cccc2ccccc12 10.1021/jm950372w
15614824 74503 0 None - 1 Human 4.6 pIC50 = 4.6 Functional
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 453 6 1 2 6.1 CC(C)CCN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00390a019
CHEMBL1907743 74503 0 None - 1 Human 4.6 pIC50 = 4.6 Functional
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 453 6 1 2 6.1 CC(C)CCN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00390a019
44280893 106012 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 652 13 4 5 5.0 CC(C)(C)CCNC(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL281671 106012 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 652 13 4 5 5.0 CC(C)(C)CCNC(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
44280193 109908 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 672 13 3 5 5.1 CN(Cc1ccccc1)C(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL30784 109908 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 672 13 3 5 5.1 CN(Cc1ccccc1)C(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
44279938 169404 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 637 10 3 4 6.0 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](Cc1ccc2ccccc2c1)C(=O)O 10.1021/jm950372w
CHEMBL416944 169404 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 637 10 3 4 6.0 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](Cc1ccc2ccccc2c1)C(=O)O 10.1021/jm950372w
15167783 74496 0 None -1 2 Human 4.6 pIC50 = 4.6 Functional
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 409 4 3 3 4.3 O=C(O)c1ccccc1C1=N[C@H](Cc2c[nH]c3ccccc23)C(=O)Nc2ccccc21 10.1021/jm00390a019
CHEMBL1907735 74496 0 None -1 2 Human 4.6 pIC50 = 4.6 Functional
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 409 4 3 3 4.3 O=C(O)c1ccccc1C1=N[C@H](Cc2c[nH]c3ccccc23)C(=O)Nc2ccccc21 10.1021/jm00390a019
44280110 109667 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 587 10 3 4 4.9 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950372w
CHEMBL30592 109667 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 587 10 3 4 4.9 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950372w
44280112 106371 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 684 11 3 5 5.4 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCCc2ccccc21 10.1021/jm950372w
CHEMBL283924 106371 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 684 11 3 5 5.4 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCCc2ccccc21 10.1021/jm950372w
15614830 74492 0 None - 1 Human 4.6 pIC50 = 4.6 Functional
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 469 6 1 4 4.7 CCOC(=O)CN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00390a019
CHEMBL1907730 74492 0 None - 1 Human 4.6 pIC50 = 4.6 Functional
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 469 6 1 4 4.7 CCOC(=O)CN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00390a019
15614828 74494 0 None - 1 Human 4.6 pIC50 = 4.6 Functional
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 454 6 1 3 4.7 CN(C)CCN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00390a019
CHEMBL1907733 74494 0 None - 1 Human 4.6 pIC50 = 4.6 Functional
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 454 6 1 3 4.7 CN(C)CCN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00390a019
44280130 168058 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 670 11 3 5 5.0 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCc2ccccc21 10.1021/jm950372w
CHEMBL412108 168058 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 670 11 3 5 5.0 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCc2ccccc21 10.1021/jm950372w
CHEMBL375360 218997 4 None 1 2 Human 7.6 pIC50 = 7.6 Functional
Activity at human CCK2 receptor expressed in HEK293 cells assessed as level of [3H]inositol produced relative to controlActivity at human CCK2 receptor expressed in HEK293 cells assessed as level of [3H]inositol produced relative to control
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm061268p
44280163 111150 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 658 12 3 5 4.7 CN(Cc1ccccc1)C(=O)[C@H](CC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL31018 111150 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 658 12 3 5 4.7 CN(Cc1ccccc1)C(=O)[C@H](CC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
44280974 106783 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 690 11 3 5 5.4 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCC2CCCCC2C1 10.1021/jm950372w
CHEMBL286763 106783 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 690 11 3 5 5.4 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCC2CCCCC2C1 10.1021/jm950372w
15167770 74499 0 None - 1 Human 4.6 pIC50 = 4.6 Functional
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 369 3 2 2 5.2 Fc1ccccc1C1=N[C@H](Cc2c[nH]c3ccccc23)CNc2ccccc21 10.1021/jm00390a019
CHEMBL1907738 74499 0 None - 1 Human 4.6 pIC50 = 4.6 Functional
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 369 3 2 2 5.2 Fc1ccccc1C1=N[C@H](Cc2c[nH]c3ccccc23)CNc2ccccc21 10.1021/jm00390a019
44280363 109117 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 511 8 2 4 3.6 CN(CC(=O)O)C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL30369 109117 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 511 8 2 4 3.6 CN(CC(=O)O)C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
108187 7713 37 None -91 5 Rat 7.5 pIC50 = 7.5 Functional
Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm970439a
873 7713 37 None -91 5 Rat 7.5 pIC50 = 7.5 Functional
Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm970439a
CHEMBL2062154 7713 37 None -91 5 Rat 7.5 pIC50 = 7.5 Functional
Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm970439a
CHEMBL287735 7713 37 None -91 5 Rat 7.5 pIC50 = 7.5 Functional
Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm970439a
9865694 210955 0 None -8 2 Human 4.5 pIC50 = 4.5 Functional
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 399 3 2 2 5.2 O=C1Nc2ccc(Cl)cc2C(c2ccccc2)=N[C@@H]1Cc1c[nH]c2ccccc12 10.1021/jm00390a019
CHEMBL70728 210955 0 None -8 2 Human 4.5 pIC50 = 4.5 Functional
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 399 3 2 2 5.2 O=C1Nc2ccc(Cl)cc2C(c2ccccc2)=N[C@@H]1Cc1c[nH]c2ccccc12 10.1021/jm00390a019
44280509 106180 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 588 10 3 5 4.3 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](Cc1ccccn1)C(=O)O 10.1021/jm950372w
CHEMBL282732 106180 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 588 10 3 5 4.3 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](Cc1ccccn1)C(=O)O 10.1021/jm950372w
44280178 109399 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 601 11 3 4 5.3 O=C(O)C[C@@H](Cc1ccccc1)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL30422 109399 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 601 11 3 4 5.3 O=C(O)C[C@@H](Cc1ccccc1)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
44280694 107056 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 571 11 3 5 4.4 CSCCC(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O 10.1021/jm950372w
CHEMBL289018 107056 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 571 11 3 5 4.4 CSCCC(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O 10.1021/jm950372w
44280246 108941 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 694 12 4 5 6.2 O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1ccc2ccccc2c1 10.1021/jm950372w
CHEMBL30262 108941 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 694 12 4 5 6.2 O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1ccc2ccccc2c1 10.1021/jm950372w
44280123 106049 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 626 10 4 4 5.3 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm950372w
CHEMBL281903 106049 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 626 10 4 4 5.3 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm950372w
44280397 110453 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 587 10 3 4 4.9 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](Cc1ccccc1)C(=O)O 10.1021/jm950372w
CHEMBL30875 110453 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 587 10 3 4 4.9 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](Cc1ccccc1)C(=O)O 10.1021/jm950372w
44280233 105984 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 672 13 3 5 5.1 CN(Cc1ccccc1)C(=O)[C@@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL281490 105984 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 672 13 3 5 5.1 CN(Cc1ccccc1)C(=O)[C@@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
44279937 111639 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 690 11 3 5 5.6 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL31101 111639 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 690 11 3 5 5.6 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
44351445 123712 0 None - 1 Rat 7.4 pIC50 = 7.4 Functional
Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)
ChEMBL 654 8 3 6 5.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(Cl)cc2Cl)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL338525 123712 0 None - 1 Rat 7.4 pIC50 = 7.4 Functional
Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)
ChEMBL 654 8 3 6 5.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(Cl)cc2Cl)C[C@@H]1C(=O)O 10.1021/jm970439a
44280234 109062 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 658 13 4 5 4.7 O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NCc1ccccc1 10.1021/jm950372w
CHEMBL30335 109062 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 658 13 4 5 4.7 O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NCc1ccccc1 10.1021/jm950372w
15556550 74497 0 None 1 2 Human 4.4 pIC50 = 4.4 Functional
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 326 3 1 2 4.5 CC(C)C[C@H]1N=C(c2ccccc2)c2cc(Cl)ccc2NC1=O 10.1021/jm00390a019
CHEMBL1907736 74497 0 None 1 2 Human 4.4 pIC50 = 4.4 Functional
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 326 3 1 2 4.5 CC(C)C[C@H]1N=C(c2ccccc2)c2cc(Cl)ccc2NC1=O 10.1021/jm00390a019
44351444 123664 0 None - 1 Rat 6.4 pIC50 = 6.4 Functional
Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)
ChEMBL 622 8 3 6 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(F)cc2F)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL338300 123664 0 None - 1 Rat 6.4 pIC50 = 6.4 Functional
Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)
ChEMBL 622 8 3 6 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(F)cc2F)C[C@@H]1C(=O)O 10.1021/jm970439a
5311201 214174 35 None -7 7 Rat 7.4 pIC50 = 7.4 Functional
Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm970439a
CHEMBL9387 214174 35 None -7 7 Rat 7.4 pIC50 = 7.4 Functional
Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm970439a
44280502 106162 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 672 14 4 5 4.8 O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NCCc1ccccc1 10.1021/jm950372w
CHEMBL282639 106162 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 672 14 4 5 4.8 O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NCCc1ccccc1 10.1021/jm950372w
44418924 163661 0 None -8 5 Human 8.3 pIC50 = 8.3 Functional
Activity at human CCK2 receptor expressed in HEK293 cells assessed as level of [3H]inositol produced relative to controlActivity at human CCK2 receptor expressed in HEK293 cells assessed as level of [3H]inositol produced relative to control
ChEMBL 1031 27 13 12 0.2 CCCC[C@H](NC(=O)[C@H](N)Cc1cc2ccccc2[nH]1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061268p
CHEMBL407198 163661 0 None -8 5 Human 8.3 pIC50 = 8.3 Functional
Activity at human CCK2 receptor expressed in HEK293 cells assessed as level of [3H]inositol produced relative to controlActivity at human CCK2 receptor expressed in HEK293 cells assessed as level of [3H]inositol produced relative to control
ChEMBL 1031 27 13 12 0.2 CCCC[C@H](NC(=O)[C@H](N)Cc1cc2ccccc2[nH]1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061268p
9800177 74483 0 None 1 2 Human 4.4 pIC50 = 4.4 Functional
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 383 3 2 2 4.7 O=C1Nc2ccccc2C(c2ccccc2F)=N[C@@H]1Cc1c[nH]c2ccccc12 10.1021/jm00390a019
CHEMBL1907714 74483 0 None 1 2 Human 4.4 pIC50 = 4.4 Functional
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 383 3 2 2 4.7 O=C1Nc2ccccc2C(c2ccccc2F)=N[C@@H]1Cc1c[nH]c2ccccc12 10.1021/jm00390a019
44280350 106628 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 658 12 3 5 4.7 CN(Cc1ccccc1)C(=O)C[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O 10.1021/jm950372w
CHEMBL285739 106628 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 658 12 3 5 4.7 CN(Cc1ccccc1)C(=O)C[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O 10.1021/jm950372w
44396745 131816 0 None -4 2 Human 5.4 pIC50 = 5.4 Functional
Inhibition of (Thr,Nle)-CCK-9-induced inositol phosphate production in COS-7 cells expressing human CCK2 receptorInhibition of (Thr,Nle)-CCK-9-induced inositol phosphate production in COS-7 cells expressing human CCK2 receptor
ChEMBL 623 8 2 6 5.5 CN(C)c1ccc(N2C(=O)CC3[C@H](N[C@@H](Cc4c[nH]c5ccccc45)C(=O)OC4C5CC6CC(C5)CC4C6)CCCN3C2=O)cc1 10.1021/jm0498755
CHEMBL364334 131816 0 None -4 2 Human 5.4 pIC50 = 5.4 Functional
Inhibition of (Thr,Nle)-CCK-9-induced inositol phosphate production in COS-7 cells expressing human CCK2 receptorInhibition of (Thr,Nle)-CCK-9-induced inositol phosphate production in COS-7 cells expressing human CCK2 receptor
ChEMBL 623 8 2 6 5.5 CN(C)c1ccc(N2C(=O)CC3[C@H](N[C@@H](Cc4c[nH]c5ccccc45)C(=O)OC4C5CC6CC(C5)CC4C6)CCCN3C2=O)cc1 10.1021/jm0498755
44280894 120287 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 708 19 3 5 6.6 CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL33209 120287 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 708 19 3 5 6.6 CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
44280381 109721 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 511 9 3 4 3.6 O=C(O)CCNC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL30634 109721 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 511 9 3 4 3.6 O=C(O)CCNC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
44280111 106745 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 684 11 3 5 5.0 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCc2ccccc2C1 10.1021/jm950372w
CHEMBL286510 106745 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 684 11 3 5 5.0 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCc2ccccc2C1 10.1021/jm950372w
15614734 74491 1 None -2 2 Human 4.3 pIC50 = 4.3 Functional
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 411 3 0 3 4.7 CN1C(=O)[C@@H](Cc2cn(C)c3ccccc23)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00390a019
CHEMBL1907729 74491 1 None -2 2 Human 4.3 pIC50 = 4.3 Functional
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 411 3 0 3 4.7 CN1C(=O)[C@@H](Cc2cn(C)c3ccccc23)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00390a019
15167776 74490 0 None 4 2 Human 5.3 pIC50 = 5.3 Functional
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 441 5 2 3 4.2 O=C(O)CN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00390a019
CHEMBL1907728 74490 0 None 4 2 Human 5.3 pIC50 = 5.3 Functional
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 441 5 2 3 4.2 O=C(O)CN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00390a019
14444002 127832 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
In vitro inhibition of binding of [125I](Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I](Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 635 15 6 6 3.8 CC(C)CC(CC(=O)NC(CC(=O)O)C(=O)NCc1ccccc1)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00123a003
CHEMBL356844 127832 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
In vitro inhibition of binding of [125I](Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I](Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 635 15 6 6 3.8 CC(C)CC(CC(=O)NC(CC(=O)O)C(=O)NCc1ccccc1)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00123a003
15614807 74501 1 None 1 2 Human 4.3 pIC50 = 4.3 Functional
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 365 3 2 2 4.6 O=C1Nc2ccccc2C(c2ccccc2)=N[C@@H]1Cc1c[nH]c2ccccc12 10.1021/jm00390a019
CHEMBL1907740 74501 1 None 1 2 Human 4.3 pIC50 = 4.3 Functional
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 365 3 2 2 4.6 O=C1Nc2ccccc2C(c2ccccc2)=N[C@@H]1Cc1c[nH]c2ccccc12 10.1021/jm00390a019
44351446 162920 0 None - 1 Rat 6.3 pIC50 = 6.3 Functional
Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)
ChEMBL 631 9 3 8 4.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc([N+](=O)[O-])cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL406359 162920 0 None - 1 Rat 6.3 pIC50 = 6.3 Functional
Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)
ChEMBL 631 9 3 8 4.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc([N+](=O)[O-])cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
44279957 105987 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 553 10 3 4 4.7 CC(C)CC(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O 10.1021/jm950372w
CHEMBL281507 105987 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 553 10 3 4 4.7 CC(C)CC(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O 10.1021/jm950372w
44280091 175217 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 640 10 3 4 5.7 CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm950372w
CHEMBL434967 175217 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 640 10 3 4 5.7 CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm950372w
44280244 19998 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 695 12 4 6 5.6 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2cccnc12 10.1021/jm950372w
CHEMBL1191257 19998 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 695 12 4 6 5.6 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2cccnc12 10.1021/jm950372w
CHEMBL542330 19998 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 695 12 4 6 5.6 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2cccnc12 10.1021/jm950372w
44280103 174737 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 573 8 2 4 5.4 CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)c1ccccc1C(=O)O 10.1021/jm950372w
CHEMBL431692 174737 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 573 8 2 4 5.4 CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)c1ccccc1C(=O)O 10.1021/jm950372w
44280315 108396 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 672 13 3 5 5.1 CN(Cc1ccccc1)C(=O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O 10.1021/jm950372w
CHEMBL29891 108396 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 672 13 3 5 5.1 CN(Cc1ccccc1)C(=O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O 10.1021/jm950372w
44280102 109486 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 587 10 3 4 4.9 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(Cc1ccccc1)C(=O)O 10.1021/jm950372w
CHEMBL30481 109486 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 587 10 3 4 4.9 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(Cc1ccccc1)C(=O)O 10.1021/jm950372w
44280387 126546 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 559 8 3 4 5.4 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)Nc1ccccc1C(=O)O 10.1021/jm950372w
CHEMBL34797 126546 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 559 8 3 4 5.4 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)Nc1ccccc1C(=O)O 10.1021/jm950372w
44351455 123597 0 None - 1 Rat 7.3 pIC50 = 7.3 Functional
Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)
ChEMBL 604 8 3 6 4.6 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(F)cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL337934 123597 0 None - 1 Rat 7.3 pIC50 = 7.3 Functional
Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)
ChEMBL 604 8 3 6 4.6 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(F)cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
44351454 123596 0 None - 1 Rat 7.3 pIC50 = 7.3 Functional
Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)
ChEMBL 712 8 3 6 5.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(I)cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL337933 123596 0 None - 1 Rat 7.3 pIC50 = 7.3 Functional
Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)
ChEMBL 712 8 3 6 5.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(I)cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
44280375 105884 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 559 8 3 4 5.4 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)Nc1ccc(C(=O)O)cc1 10.1021/jm950372w
CHEMBL280832 105884 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 559 8 3 4 5.4 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)Nc1ccc(C(=O)O)cc1 10.1021/jm950372w
44280621 110702 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 658 13 4 5 4.4 O=C(O)C[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NCCc1ccccc1 10.1021/jm950372w
CHEMBL30926 110702 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 658 13 4 5 4.4 O=C(O)C[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NCCc1ccccc1 10.1021/jm950372w
15167804 74485 0 None 1 2 Human 5.2 pIC50 = 5.2 Functional
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 455 6 2 3 4.6 O=C(O)CCN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00390a019
CHEMBL1907719 74485 0 None 1 2 Human 5.2 pIC50 = 5.2 Functional
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 455 6 2 3 4.6 O=C(O)CCN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00390a019
15614820 74498 0 None -1 2 Human 4.2 pIC50 = 4.2 Functional
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 437 5 1 2 5.5 O=C1[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc2N1CC1CC1 10.1021/jm00390a019
CHEMBL1907737 74498 0 None -1 2 Human 4.2 pIC50 = 4.2 Functional
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 437 5 1 2 5.5 O=C1[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc2N1CC1CC1 10.1021/jm00390a019
44280000 110030 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 525 10 3 4 4.0 O=C(O)CCCNC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL30844 110030 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 525 10 3 4 4.0 O=C(O)CCCNC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
15167820 74488 0 None -1 2 Human 4.2 pIC50 = 4.2 Functional
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 393 3 0 3 4.6 CN1C(=O)[C@@H](Cc2cn(C)c3ccccc23)N=C(c2ccccc2)c2ccccc21 10.1021/jm00390a019
CHEMBL1907724 74488 0 None -1 2 Human 4.2 pIC50 = 4.2 Functional
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 393 3 0 3 4.6 CN1C(=O)[C@@H](Cc2cn(C)c3ccccc23)N=C(c2ccccc2)c2ccccc21 10.1021/jm00390a019
44280599 105938 0 None 630 2 Human 8.2 pIC50 = 8.2 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 694 12 4 5 6.2 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2ccccc12 10.1021/jm950372w
CHEMBL281206 105938 0 None 630 2 Human 8.2 pIC50 = 8.2 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 694 12 4 5 6.2 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2ccccc12 10.1021/jm950372w
44280122 106275 0 None 169 2 Human 8.2 pIC50 = 8.2 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 640 10 3 4 5.7 CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)[C@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm950372w
CHEMBL283276 106275 0 None 169 2 Human 8.2 pIC50 = 8.2 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 640 10 3 4 5.7 CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)[C@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm950372w
44280993 125115 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 678 12 4 5 5.5 CC1(C)CCC(NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCC3)CC2)CC1 10.1021/jm950372w
CHEMBL34101 125115 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 678 12 4 5 5.5 CC1(C)CCC(NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCC3)CC2)CC1 10.1021/jm950372w
39760 74539 3 None - 1 Human 4.2 pIC50 = 4.2 Functional
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 399 3 2 2 5.2 O=C1Nc2ccc(Cl)cc2C(c2ccccc2)=N[C@H]1Cc1c[nH]c2ccccc12 10.1021/jm00390a019
CHEMBL1907931 74539 3 None - 1 Human 4.2 pIC50 = 4.2 Functional
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 399 3 2 2 5.2 O=C1Nc2ccc(Cl)cc2C(c2ccccc2)=N[C@H]1Cc1c[nH]c2ccccc12 10.1021/jm00390a019
44280398 106021 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 601 10 2 4 5.2 CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(Cc1ccccc1)C(=O)O 10.1021/jm950372w
CHEMBL281728 106021 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 601 10 2 4 5.2 CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(Cc1ccccc1)C(=O)O 10.1021/jm950372w
44351519 175298 0 None - 1 Rat 7.1 pIC50 = 7.1 Functional
Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)
ChEMBL 620 8 3 6 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(Cl)cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL435404 175298 0 None - 1 Rat 7.1 pIC50 = 7.1 Functional
Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)
ChEMBL 620 8 3 6 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(Cl)cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
44280508 106602 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 601 10 3 4 5.3 CC(Cc1ccccc1)(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O 10.1021/jm950372w
CHEMBL285559 106602 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 601 10 3 4 5.3 CC(Cc1ccccc1)(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O 10.1021/jm950372w
44280205 19840 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 695 12 4 6 5.6 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2ncccc12 10.1021/jm950372w
CHEMBL1190133 19840 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 695 12 4 6 5.6 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2ncccc12 10.1021/jm950372w
CHEMBL540261 19840 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 695 12 4 6 5.6 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2ncccc12 10.1021/jm950372w
44280729 175008 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 644 12 4 5 4.3 O=C(CC(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O)NCc1ccccc1 10.1021/jm950372w
CHEMBL433621 175008 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 644 12 4 5 4.3 O=C(CC(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O)NCc1ccccc1 10.1021/jm950372w
168269598 196788 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at pig cerebral cortex CCK2 human by Packbard-Cobra counter analysisAntagonist activity at pig cerebral cortex CCK2 human by Packbard-Cobra counter analysis
ChEMBL 325 6 0 4 3.3 C#CCOC1OC(=O)C(Cl)=C1N(CC(C)C)C1CCCCC1 10.1016/j.bmc.2022.116815
CHEMBL5171437 196788 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at pig cerebral cortex CCK2 human by Packbard-Cobra counter analysisAntagonist activity at pig cerebral cortex CCK2 human by Packbard-Cobra counter analysis
ChEMBL 325 6 0 4 3.3 C#CCOC1OC(=O)C(Cl)=C1N(CC(C)C)C1CCCCC1 10.1016/j.bmc.2022.116815
44280507 120273 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 573 9 3 4 5.0 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(C(=O)O)c1ccccc1 10.1021/jm950372w
CHEMBL33200 120273 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 573 9 3 4 5.0 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(C(=O)O)c1ccccc1 10.1021/jm950372w
136067266 74500 0 None - 1 Human 4.1 pIC50 = 4.1 Functional
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 303 2 2 2 3.5 CC1=N[C@H](Cc2c[nH]c3ccccc23)C(=O)Nc2ccccc21 10.1021/jm00390a019
CHEMBL1907739 74500 0 None - 1 Human 4.1 pIC50 = 4.1 Functional
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 303 2 2 2 3.5 CC1=N[C@H](Cc2c[nH]c3ccccc23)C(=O)Nc2ccccc21 10.1021/jm00390a019
4355450 142705 50 None -12 3 Human 7.1 pIC50 = 7.1 Functional
Antagonistic activity against cholecystokinin type B receptorAntagonistic activity against cholecystokinin type B receptor
ChEMBL 501 6 1 4 6.2 CC(C)Oc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00067a001
CHEMBL37312 142705 50 None -12 3 Human 7.1 pIC50 = 7.1 Functional
Antagonistic activity against cholecystokinin type B receptorAntagonistic activity against cholecystokinin type B receptor
ChEMBL 501 6 1 4 6.2 CC(C)Oc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00067a001
44280270 105994 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 601 10 2 4 5.2 CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)[C@H](Cc1ccccc1)C(=O)O 10.1021/jm950372w
CHEMBL281560 105994 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 601 10 2 4 5.2 CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)[C@H](Cc1ccccc1)C(=O)O 10.1021/jm950372w
168286058 198100 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at pig cerebral cortex CCK2 human by Packbard-Cobra counter analysisAntagonist activity at pig cerebral cortex CCK2 human by Packbard-Cobra counter analysis
ChEMBL 295 6 1 4 2.8 CC(C)CNC1=C(Cl)C(=O)OC1OCc1ccccc1 10.1016/j.bmc.2022.116815
CHEMBL5191421 198100 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at pig cerebral cortex CCK2 human by Packbard-Cobra counter analysisAntagonist activity at pig cerebral cortex CCK2 human by Packbard-Cobra counter analysis
ChEMBL 295 6 1 4 2.8 CC(C)CNC1=C(Cl)C(=O)OC1OCc1ccccc1 10.1016/j.bmc.2022.116815
44280176 106086 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 615 12 3 4 5.6 O=C(O)CCC(Cc1ccccc1)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL282099 106086 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 615 12 3 4 5.6 O=C(O)CCC(Cc1ccccc1)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
44280973 106643 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 704 12 4 5 5.9 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NC1CCC2CCCCC2C1 10.1021/jm950372w
CHEMBL285857 106643 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 704 12 4 5 5.9 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NC1CCC2CCCCC2C1 10.1021/jm950372w
44280269 105993 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 626 10 4 4 5.3 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm950372w
CHEMBL281559 105993 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 626 10 4 4 5.3 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm950372w
44279939 106093 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 637 10 3 4 6.0 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](Cc1cccc2ccccc12)C(=O)O 10.1021/jm950372w
CHEMBL282149 106093 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 637 10 3 4 6.0 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](Cc1cccc2ccccc12)C(=O)O 10.1021/jm950372w
44280501 106799 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 698 12 4 5 5.6 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NC1CCCc2ccccc21 10.1021/jm950372w
CHEMBL286847 106799 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 698 12 4 5 5.6 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NC1CCCc2ccccc21 10.1021/jm950372w
44280414 108636 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 708 13 4 5 5.9 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NCc1cccc2ccccc12 10.1021/jm950372w
CHEMBL30061 108636 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 708 13 4 5 5.9 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NCc1cccc2ccccc12 10.1021/jm950372w
44280407 126489 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 658 12 3 5 4.7 CN(Cc1ccccc1)C(=O)[C@@H](CC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL34743 126489 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 658 12 3 5 4.7 CN(Cc1ccccc1)C(=O)[C@@H](CC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
44280380 106616 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 553 11 3 4 4.8 CCCCC(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O 10.1021/jm950372w
CHEMBL285657 106616 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 553 11 3 4 4.8 CCCCC(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O 10.1021/jm950372w
44280101 106369 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 573 9 3 4 5.3 O=C(O)Cc1cccc(NC(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCC3)CC2)c1 10.1021/jm950372w
CHEMBL283920 106369 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 573 9 3 4 5.3 O=C(O)Cc1cccc(NC(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCC3)CC2)c1 10.1021/jm950372w
44279985 109880 0 None - 1 Human 6.0 pIC50 = 6 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 511 8 3 4 3.6 CC(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O 10.1021/jm950372w
CHEMBL30764 109880 0 None - 1 Human 6.0 pIC50 = 6 Functional
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 511 8 3 4 3.6 CC(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O 10.1021/jm950372w
887 10882 33 None 1 3 Rat 10.1 pKd = 10.1 Functional
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 10.1021/jm051219x
9870520 10882 33 None 1 3 Rat 10.1 pKd = 10.1 Functional
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 10.1021/jm051219x
CHEMBL324547 10882 33 None 1 3 Rat 10.1 pKd = 10.1 Functional
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 10.1021/jm051219x
DB12355 10882 33 None 1 3 Rat 10.1 pKd = 10.1 Functional
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 10.1021/jm051219x
887 10882 33 None 1 3 Rat 10.1 pKd = 10.1 Functional
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 10.1021/jm070139l
9870520 10882 33 None 1 3 Rat 10.1 pKd = 10.1 Functional
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 10.1021/jm070139l
CHEMBL324547 10882 33 None 1 3 Rat 10.1 pKd = 10.1 Functional
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 10.1021/jm070139l
DB12355 10882 33 None 1 3 Rat 10.1 pKd = 10.1 Functional
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 10.1021/jm070139l
11498528 79251 0 None - 0 Rat 9.2 pKd = 9.2 Functional
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 503 7 3 4 6.1 O=C(O)c1cccc(NC(=O)c2[nH]c(C34CCC(CC3)CC4)nc2COC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
CHEMBL198933 79251 0 None - 0 Rat 9.2 pKd = 9.2 Functional
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 503 7 3 4 6.1 O=C(O)c1cccc(NC(=O)c2[nH]c(C34CCC(CC3)CC4)nc2COC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
16732163 148842 0 None - 0 Rat 9.1 pKd = 9.1 Functional
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 544 9 2 5 5.2 O=C(O)Cc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1021/jm070139l
CHEMBL387948 148842 0 None - 0 Rat 9.1 pKd = 9.1 Functional
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 544 9 2 5 5.2 O=C(O)Cc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1021/jm070139l
16732164 150081 0 None - 0 Rat 9.1 pKd = 9.1 Functional
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 571 8 2 6 5.5 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2ccc3ccn(CC(=O)O)c3c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL389711 150081 0 None - 0 Rat 9.1 pKd = 9.1 Functional
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 571 8 2 6 5.5 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2ccc3ccn(CC(=O)O)c3c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
9832467 151071 0 None - 1 Rat 9.1 pKd = 9.1 Functional
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 477 7 3 4 5.9 O=C(O)c1cccc(NC(=O)c2nc(C3CCCCC3)[nH]c2COC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
CHEMBL390519 151071 0 None - 1 Rat 9.1 pKd = 9.1 Functional
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 477 7 3 4 5.9 O=C(O)c1cccc(NC(=O)c2nc(C3CCCCC3)[nH]c2COC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
9832467 151071 0 None - 1 Rat 9.1 pKd = 9.1 Functional
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 477 7 3 4 5.9 O=C(O)c1cccc(NC(=O)c2nc(C3CCCCC3)[nH]c2COC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm070139l
CHEMBL390519 151071 0 None - 1 Rat 9.1 pKd = 9.1 Functional
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 477 7 3 4 5.9 O=C(O)c1cccc(NC(=O)c2nc(C3CCCCC3)[nH]c2COC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm070139l
11555184 172811 0 None - 1 Rat 9.1 pKd = 9.1 Functional
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 503 7 3 3 7.0 Cc1ccc(NC(=O)c2[nH]c(C3(C)CCCCC3)nc2CCC23CC4CC(CC(C4)C2)C3)cc1C(=O)O 10.1021/jm0490686
CHEMBL425574 172811 0 None - 1 Rat 9.1 pKd = 9.1 Functional
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 503 7 3 3 7.0 Cc1ccc(NC(=O)c2[nH]c(C3(C)CCCCC3)nc2CCC23CC4CC(CC(C4)C2)C3)cc1C(=O)O 10.1021/jm0490686
11527738 82764 0 None - 0 Rat 9.0 pKd = 9.0 Functional
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 518 7 2 5 5.2 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
CHEMBL205455 82764 0 None - 0 Rat 9.0 pKd = 9.0 Functional
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 518 7 2 5 5.2 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
11527738 82764 0 None - 0 Rat 9.0 pKd = 9.0 Functional
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 518 7 2 5 5.2 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL205455 82764 0 None - 0 Rat 9.0 pKd = 9.0 Functional
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 518 7 2 5 5.2 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
16733466 92292 0 None - 0 Rat 8.9 pKd = 8.9 Functional
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 558 10 2 5 5.6 O=C(O)CCc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1021/jm070139l
CHEMBL227330 92292 0 None - 0 Rat 8.9 pKd = 8.9 Functional
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 558 10 2 5 5.6 O=C(O)CCc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1021/jm070139l
11605814 82203 0 None - 0 Rat 8.9 pKd = 8.9 Functional
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 503 7 2 5 5.5 CNc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
CHEMBL204154 82203 0 None - 0 Rat 8.9 pKd = 8.9 Functional
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 503 7 2 5 5.5 CNc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
16733469 92293 0 None - 0 Rat 8.8 pKd = 8.8 Functional
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 576 10 2 6 5.8 O=C(O)CSc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1021/jm070139l
CHEMBL227333 92293 0 None - 0 Rat 8.8 pKd = 8.8 Functional
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 576 10 2 6 5.8 O=C(O)CSc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1021/jm070139l
11571142 142584 0 None - 0 Rat 8.8 pKd = 8.8 Functional
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 489 7 3 3 6.7 CC1(c2nc(C(=O)Nc3cccc(C(=O)O)c3)c(CCC34CC5CC(CC(C5)C3)C4)[nH]2)CCCCC1 10.1021/jm0490686
CHEMBL373050 142584 0 None - 0 Rat 8.8 pKd = 8.8 Functional
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 489 7 3 3 6.7 CC1(c2nc(C(=O)Nc3cccc(C(=O)O)c3)c(CCC34CC5CC(CC(C5)C3)C4)[nH]2)CCCCC1 10.1021/jm0490686
135423404 92287 0 None - 0 Rat 8.7 pKd = 8.7 Functional
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 570 8 2 7 5.0 O=C(CN1N=C(C2CCCCC2)c2ccccc2N(CC(=O)C2CCCC2)C1=O)Nc1cccc(-c2noc(=O)[nH]2)c1 10.1021/jm070139l
CHEMBL227276 92287 0 None - 0 Rat 8.7 pKd = 8.7 Functional
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 570 8 2 7 5.0 O=C(CN1N=C(C2CCCCC2)c2ccccc2N(CC(=O)C2CCCC2)C1=O)Nc1cccc(-c2noc(=O)[nH]2)c1 10.1021/jm070139l
16731872 92224 0 None - 0 Rat 8.7 pKd = 8.7 Functional
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 530 8 2 5 5.3 O=C(CN1N=C(C2CCCCC2)c2ccccc2N(CC(=O)C2CCCC2)C1=O)Nc1cccc(C(=O)O)c1 10.1021/jm070139l
CHEMBL226620 92224 0 None - 0 Rat 8.7 pKd = 8.7 Functional
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 530 8 2 5 5.3 O=C(CN1N=C(C2CCCCC2)c2ccccc2N(CC(=O)C2CCCC2)C1=O)Nc1cccc(C(=O)O)c1 10.1021/jm070139l
11679213 140321 0 None - 0 Rat 8.0 pKd = 8 Functional
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 497 7 3 3 6.8 Cc1ccc(-c2nc(C(=O)Nc3cccc(C(=O)O)c3)c(CCC34CC5CC(CC(C5)C3)C4)[nH]2)c(C)c1 10.1021/jm0490686
CHEMBL370882 140321 0 None - 0 Rat 8.0 pKd = 8 Functional
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 497 7 3 3 6.8 Cc1ccc(-c2nc(C(=O)Nc3cccc(C(=O)O)c3)c(CCC34CC5CC(CC(C5)C3)C4)[nH]2)c(C)c1 10.1021/jm0490686
11568611 78754 0 None - 0 Rat 8.0 pKd = 8.0 Functional
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 449 6 3 3 5.8 CC(C)(C)c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
CHEMBL197370 78754 0 None - 0 Rat 8.0 pKd = 8.0 Functional
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 449 6 3 3 5.8 CC(C)(C)c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
11571166 148092 0 None - 0 Rat 7.0 pKd = 7 Functional
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 497 7 3 3 6.8 Cc1cccc(C)c1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
CHEMBL383386 148092 0 None - 0 Rat 7.0 pKd = 7 Functional
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 497 7 3 3 6.8 Cc1cccc(C)c1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
11592162 83304 0 None - 0 Rat 7.0 pKd = 7.0 Functional
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 561 11 2 6 5.9 CCOCCNc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
CHEMBL206079 83304 0 None - 0 Rat 7.0 pKd = 7.0 Functional
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 561 11 2 6 5.9 CCOCCNc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
11699148 82756 0 None - 0 Rat 6.0 pKd = 6.0 Functional
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 511 7 2 6 3.4 CNc1cccc(NC(=O)CN2N=C(c3ccccn3)c3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 10.1021/jm051219x
CHEMBL205423 82756 0 None - 0 Rat 6.0 pKd = 6.0 Functional
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 511 7 2 6 3.4 CNc1cccc(NC(=O)CN2N=C(c3ccccn3)c3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 10.1021/jm051219x
11584903 147517 0 None - 0 Rat 6.9 pKd = 6.9 Functional
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 560 10 2 6 5.1 CNCCN(C)c1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
CHEMBL381805 147517 0 None - 0 Rat 6.9 pKd = 6.9 Functional
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 560 10 2 6 5.1 CNCCN(C)c1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
11505466 78805 0 None - 0 Rat 5.9 pKd = 5.9 Functional
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 425 7 3 3 5.1 Cc1ccccc1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCc2ccccc2)[nH]1 10.1021/jm0490686
CHEMBL197578 78805 0 None - 0 Rat 5.9 pKd = 5.9 Functional
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 425 7 3 3 5.1 Cc1ccccc1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCc2ccccc2)[nH]1 10.1021/jm0490686
44451547 103487 0 None - 0 Rat 7.9 pKd = 7.9 Functional
Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretionAntagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretion
ChEMBL 587 8 2 8 4.7 CN(c1cccc(NC(=O)CN2C(=O)N(CC(=O)C(C)(C)C)c3ccccc3N(C3CCCCC3)C2=O)c1)c1nn[nH]n1 10.1016/j.bmc.2007.12.047
CHEMBL264150 103487 0 None - 0 Rat 7.9 pKd = 7.9 Functional
Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretionAntagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretion
ChEMBL 587 8 2 8 4.7 CN(c1cccc(NC(=O)CN2C(=O)N(CC(=O)C(C)(C)C)c3ccccc3N(C3CCCCC3)C2=O)c1)c1nn[nH]n1 10.1016/j.bmc.2007.12.047
11613212 78876 0 None - 1 Rat 7.9 pKd = 7.9 Functional
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 513 7 3 4 6.4 Cc1cc(C)c(-c2nc(C(=O)Nc3cccc(C(=O)O)c3)c(COC34CC5CC(CC(C5)C3)C4)[nH]2)c(C)c1 10.1021/jm0490686
CHEMBL197780 78876 0 None - 1 Rat 7.9 pKd = 7.9 Functional
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 513 7 3 4 6.4 Cc1cc(C)c(-c2nc(C(=O)Nc3cccc(C(=O)O)c3)c(COC34CC5CC(CC(C5)C3)C4)[nH]2)c(C)c1 10.1021/jm0490686
11663308 83520 1 None - 0 Rat 6.9 pKd = 6.9 Functional
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 497 7 2 5 5.0 CNc1cccc(NC(=O)CN2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
CHEMBL206709 83520 1 None - 0 Rat 6.9 pKd = 6.9 Functional
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 497 7 2 5 5.0 CNc1cccc(NC(=O)CN2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
11613982 147203 0 None - 0 Rat 6.8 pKd = 6.8 Functional
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 543 7 1 5 6.1 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(N3CCCC3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
CHEMBL380907 147203 0 None - 0 Rat 6.8 pKd = 6.8 Functional
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 543 7 1 5 6.1 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(N3CCCC3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
11567687 142715 0 None - 0 Rat 5.8 pKd = 5.8 Functional
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 407 6 3 3 4.8 Cc1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
CHEMBL373125 142715 0 None - 0 Rat 5.8 pKd = 5.8 Functional
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 407 6 3 3 4.8 Cc1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
11656338 82720 0 None - 0 Rat 7.8 pKd = 7.8 Functional
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 504 7 2 5 5.0 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CO)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
CHEMBL205198 82720 0 None - 0 Rat 7.8 pKd = 7.8 Functional
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 504 7 2 5 5.0 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CO)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
11628273 146912 0 None - 0 Rat 7.7 pKd = 7.7 Functional
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 559 7 1 6 5.3 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(N3CCOCC3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
CHEMBL380193 146912 0 None - 0 Rat 7.7 pKd = 7.7 Functional
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 559 7 1 6 5.3 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(N3CCOCC3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
44451920 102901 0 None - 0 Rat 7.7 pKd = 7.7 Functional
Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretionAntagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretion
ChEMBL 519 7 2 5 5.5 CNc1cccc(NC(=O)CN2C(=O)N(CC(=O)C(C)(C)C)c3ccccc3N(C3CCCCC3)C2=O)c1 10.1016/j.bmc.2007.12.047
CHEMBL260394 102901 0 None - 0 Rat 7.7 pKd = 7.7 Functional
Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretionAntagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretion
ChEMBL 519 7 2 5 5.5 CNc1cccc(NC(=O)CN2C(=O)N(CC(=O)C(C)(C)C)c3ccccc3N(C3CCCCC3)C2=O)c1 10.1016/j.bmc.2007.12.047
11495719 77148 0 None - 0 Rat 7.7 pKd = 7.7 Functional
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 431 7 3 3 5.8 Cc1ccccc1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC2CCCCC2)[nH]1 10.1021/jm0490686
CHEMBL194514 77148 0 None - 0 Rat 7.7 pKd = 7.7 Functional
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 431 7 3 3 5.8 Cc1ccccc1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC2CCCCC2)[nH]1 10.1021/jm0490686
44451877 102756 0 None - 0 Rat 7.7 pKd = 7.7 Functional
Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretionAntagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretion
ChEMBL 587 7 1 6 6.9 Cc1nc(-c2cccc(NC(=O)CN3C(=O)N(CC(=O)C(C)(C)C)c4ccccc4N(C4CCCCC4)C3=O)c2)cs1 10.1016/j.bmc.2007.12.047
CHEMBL259557 102756 0 None - 0 Rat 7.7 pKd = 7.7 Functional
Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretionAntagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretion
ChEMBL 587 7 1 6 6.9 Cc1nc(-c2cccc(NC(=O)CN3C(=O)N(CC(=O)C(C)(C)C)c4ccccc4N(C4CCCCC4)C3=O)c2)cs1 10.1016/j.bmc.2007.12.047
11513177 79304 0 None - 0 Rat 8.6 pKd = 8.6 Functional
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 501 7 3 3 6.7 O=C(O)c1cccc(NC(=O)c2[nH]c(C34CCC(CC3)CC4)nc2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
CHEMBL199091 79304 0 None - 0 Rat 8.6 pKd = 8.6 Functional
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 501 7 3 3 6.7 O=C(O)c1cccc(NC(=O)c2[nH]c(C34CCC(CC3)CC4)nc2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
16732911 149994 0 None - 0 Rat 8.6 pKd = 8.6 Functional
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 564 9 2 6 5.6 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(SCC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL389639 149994 0 None - 0 Rat 8.6 pKd = 8.6 Functional
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 564 9 2 6 5.6 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(SCC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
11539356 78455 0 None - 0 Rat 7.7 pKd = 7.7 Functional
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 435 7 3 3 5.6 CC(C)c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
CHEMBL196441 78455 0 None - 0 Rat 7.7 pKd = 7.7 Functional
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 435 7 3 3 5.6 CC(C)c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
11705988 173131 0 None - 0 Rat 6.7 pKd = 6.7 Functional
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 498 7 2 6 4.4 CNc1cccc(NC(=O)CN2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
CHEMBL427387 173131 0 None - 0 Rat 6.7 pKd = 6.7 Functional
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 498 7 2 6 4.4 CNc1cccc(NC(=O)CN2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
16732020 92285 0 None - 0 Rat 7.6 pKd = 7.6 Functional
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 571 8 2 8 4.7 CN(c1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1)c1nn[nH]n1 10.1021/jm070139l
CHEMBL227254 92285 0 None - 0 Rat 7.6 pKd = 7.6 Functional
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 571 8 2 8 4.7 CN(c1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1)c1nn[nH]n1 10.1021/jm070139l
11612498 140340 0 None - 0 Rat 6.6 pKd = 6.6 Functional
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 469 7 3 3 6.2 O=C(O)c1cccc(NC(=O)c2[nH]c(-c3ccccc3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
CHEMBL371068 140340 0 None - 0 Rat 6.6 pKd = 6.6 Functional
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 469 7 3 3 6.2 O=C(O)c1cccc(NC(=O)c2[nH]c(-c3ccccc3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
11685703 78695 0 None - 0 Rat 7.6 pKd = 7.6 Functional
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 391 7 3 3 4.9 Cc1ccccc1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC(C)C)[nH]1 10.1021/jm0490686
CHEMBL197205 78695 0 None - 0 Rat 7.6 pKd = 7.6 Functional
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 391 7 3 3 4.9 Cc1ccccc1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC(C)C)[nH]1 10.1021/jm0490686
44451622 102691 0 None - 0 Rat 7.6 pKd = 7.6 Functional
Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretionAntagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretion
ChEMBL 562 9 2 5 5.5 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CCC(=O)O)c2)C(=O)N(C2CCCCC2)c2ccccc21 10.1016/j.bmc.2007.12.047
CHEMBL259276 102691 0 None - 0 Rat 7.6 pKd = 7.6 Functional
Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretionAntagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretion
ChEMBL 562 9 2 5 5.5 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CCC(=O)O)c2)C(=O)N(C2CCCCC2)c2ccccc21 10.1016/j.bmc.2007.12.047
11712880 145701 0 None - 0 Rat 7.6 pKd = 7.6 Functional
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 490 6 2 5 5.2 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
CHEMBL378388 145701 0 None - 0 Rat 7.6 pKd = 7.6 Functional
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 490 6 2 5 5.2 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
11511721 82877 0 None - 0 Rat 7.6 pKd = 7.6 Functional
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 502 7 2 5 5.5 CNc1cccc(NC(=O)C[C@@H]2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
CHEMBL205751 82877 0 None - 0 Rat 7.6 pKd = 7.6 Functional
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 502 7 2 5 5.5 CNc1cccc(NC(=O)C[C@@H]2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
11555166 146608 0 None - 0 Rat 7.5 pKd = 7.5 Functional
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 502 7 2 5 5.5 CNc1cccc(NC(=O)C[C@H]2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
CHEMBL379902 146608 0 None - 0 Rat 7.5 pKd = 7.5 Functional
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 502 7 2 5 5.5 CNc1cccc(NC(=O)C[C@H]2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
5311201 214174 35 None -7 7 Rat 7.5 pKd = 7.5 Functional
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm051219x
CHEMBL9387 214174 35 None -7 7 Rat 7.5 pKd = 7.5 Functional
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm051219x
135529065 163794 0 None - 0 Rat 8.5 pKd = 8.5 Functional
Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretionAntagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretion
ChEMBL 588 7 2 7 5.2 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nc(=O)o[nH]3)c2)C(=O)N(C2CCCCCC2)c2ccccc21 10.1016/j.bmc.2007.12.047
CHEMBL407340 163794 0 None - 0 Rat 8.5 pKd = 8.5 Functional
Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretionAntagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretion
ChEMBL 588 7 2 7 5.2 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nc(=O)o[nH]3)c2)C(=O)N(C2CCCCCC2)c2ccccc21 10.1016/j.bmc.2007.12.047
11497371 77405 0 None - 1 Rat 8.5 pKd = 8.5 Functional
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 525 7 3 3 7.4 Cc1cc(C)c(-c2nc(C(=O)Nc3ccc(C)c(C(=O)O)c3)c(CCC34CC5CC(CC(C5)C3)C4)[nH]2)c(C)c1 10.1021/jm0490686
CHEMBL195007 77405 0 None - 1 Rat 8.5 pKd = 8.5 Functional
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 525 7 3 3 7.4 Cc1cc(C)c(-c2nc(C(=O)Nc3ccc(C)c(C(=O)O)c3)c(CCC34CC5CC(CC(C5)C3)C4)[nH]2)c(C)c1 10.1021/jm0490686
11605694 175432 0 None - 0 Rat 7.5 pKd = 7.5 Functional
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 497 7 3 3 6.8 Cc1ccc(NC(=O)c2[nH]c(-c3ccccc3C)nc2CCC23CC4CC(CC(C4)C2)C3)cc1C(=O)O 10.1021/jm0490686
CHEMBL436314 175432 0 None - 0 Rat 7.5 pKd = 7.5 Functional
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 497 7 3 3 6.8 Cc1ccc(NC(=O)c2[nH]c(-c3ccccc3C)nc2CCC23CC4CC(CC(C4)C2)C3)cc1C(=O)O 10.1021/jm0490686
11576771 81206 0 None - 0 Rat 7.4 pKd = 7.4 Functional
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 489 6 2 5 5.0 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(N)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
CHEMBL202680 81206 0 None - 0 Rat 7.4 pKd = 7.4 Functional
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 489 6 2 5 5.0 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(N)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
44451581 102600 0 None - 0 Rat 8.4 pKd = 8.4 Functional
Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretionAntagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretion
ChEMBL 594 9 2 6 6.0 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(SCC(=O)O)c2)C(=O)N(C2CCCCCC2)c2ccccc21 10.1016/j.bmc.2007.12.047
CHEMBL258863 102600 0 None - 0 Rat 8.4 pKd = 8.4 Functional
Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretionAntagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretion
ChEMBL 594 9 2 6 6.0 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(SCC(=O)O)c2)C(=O)N(C2CCCCCC2)c2ccccc21 10.1016/j.bmc.2007.12.047
16731874 92233 0 None - 0 Rat 8.4 pKd = 8.4 Functional
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 546 9 2 5 5.5 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CCC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL226675 92233 0 None - 0 Rat 8.4 pKd = 8.4 Functional
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 546 9 2 5 5.5 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CCC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
11540160 78223 0 None - 1 Rat 8.3 pKd = 8.3 Functional
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 475 7 3 3 6.6 O=C(O)c1cccc(NC(=O)c2[nH]c(C3CCCCC3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
CHEMBL196133 78223 0 None - 1 Rat 8.3 pKd = 8.3 Functional
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 475 7 3 3 6.6 O=C(O)c1cccc(NC(=O)c2[nH]c(C3CCCCC3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
44451843 166218 0 None - 0 Rat 7.4 pKd = 7.4 Functional
Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretionAntagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretion
ChEMBL 562 8 2 5 5.5 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CC(=O)O)c2)C(=O)N(C2CCCCCC2)c2ccccc21 10.1016/j.bmc.2007.12.047
CHEMBL410114 166218 0 None - 0 Rat 7.4 pKd = 7.4 Functional
Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretionAntagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretion
ChEMBL 562 8 2 5 5.5 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CC(=O)O)c2)C(=O)N(C2CCCCCC2)c2ccccc21 10.1016/j.bmc.2007.12.047
136036823 162457 0 None - 0 Rat 7.4 pKd = 7.4 Functional
Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretionAntagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretion
ChEMBL 574 7 2 7 4.8 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nc(=O)o[nH]3)c2)C(=O)N(C2CCCCC2)c2ccccc21 10.1016/j.bmc.2007.12.047
CHEMBL404967 162457 0 None - 0 Rat 7.4 pKd = 7.4 Functional
Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretionAntagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretion
ChEMBL 574 7 2 7 4.8 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nc(=O)o[nH]3)c2)C(=O)N(C2CCCCC2)c2ccccc21 10.1016/j.bmc.2007.12.047
11571140 78476 0 None - 0 Rat 8.3 pKd = 8.3 Functional
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 489 7 3 3 6.9 O=C(O)c1cccc(NC(=O)c2[nH]c(C3CCCCCC3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
CHEMBL196517 78476 0 None - 0 Rat 8.3 pKd = 8.3 Functional
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 489 7 3 3 6.9 O=C(O)c1cccc(NC(=O)c2[nH]c(C3CCCCCC3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
11512112 82367 0 None - 0 Rat 7.3 pKd = 7.3 Functional
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 532 8 2 6 4.9 CNc1cccc(NC(=O)CN2N=C(c3ccccn3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1 10.1021/jm051219x
CHEMBL204683 82367 0 None - 0 Rat 7.3 pKd = 7.3 Functional
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 532 8 2 6 4.9 CNc1cccc(NC(=O)CN2N=C(c3ccccn3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1 10.1021/jm051219x
11643045 78913 0 None - 0 Rat 6.3 pKd = 6.3 Functional
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 511 9 3 3 6.8 Cc1ccccc1-c1nc(C(=O)Nc2cccc(CCC(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
CHEMBL197873 78913 0 None - 0 Rat 6.3 pKd = 6.3 Functional
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 511 9 3 3 6.8 Cc1ccccc1-c1nc(C(=O)Nc2cccc(CCC(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
11698512 175034 0 None - 0 Rat 7.3 pKd = 7.3 Functional
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 435 8 3 3 5.5 CCCc1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
CHEMBL433776 175034 0 None - 0 Rat 7.3 pKd = 7.3 Functional
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 435 8 3 3 5.5 CCCc1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
11542079 78497 0 None - 0 Rat 7.2 pKd = 7.2 Functional
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 483 7 3 3 6.5 Cc1ccccc1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
CHEMBL196580 78497 0 None - 0 Rat 7.2 pKd = 7.2 Functional
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 483 7 3 3 6.5 Cc1ccccc1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
11518283 172939 0 None - 0 Rat 8.2 pKd = 8.2 Functional
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 461 7 3 3 6.2 O=C(O)c1cccc(NC(=O)c2[nH]c(C3CCCC3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
CHEMBL426290 172939 0 None - 0 Rat 8.2 pKd = 8.2 Functional
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 461 7 3 3 6.2 O=C(O)c1cccc(NC(=O)c2[nH]c(C3CCCC3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
16732753 150764 0 None - 0 Rat 8.1 pKd = 8.1 Functional
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 552 8 2 5 5.7 Cc1ccccc1C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL390276 150764 0 None - 0 Rat 8.1 pKd = 8.1 Functional
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 552 8 2 5 5.7 Cc1ccccc1C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
16732019 92209 0 None - 0 Rat 8.1 pKd = 8.1 Functional
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 542 7 2 7 4.6 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nn[nH]n3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL226533 92209 0 None - 0 Rat 8.1 pKd = 8.1 Functional
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 542 7 2 7 4.6 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nn[nH]n3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
11541870 78226 0 None - 0 Rat 7.2 pKd = 7.2 Functional
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 433 7 3 3 5.4 O=C(O)c1cccc(NC(=O)c2[nH]c(C3CC3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
CHEMBL196141 78226 0 None - 0 Rat 7.2 pKd = 7.2 Functional
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 433 7 3 3 5.4 O=C(O)c1cccc(NC(=O)c2[nH]c(C3CC3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
44451523 102718 0 None - 0 Rat 6.2 pKd = 6.2 Functional
Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretionAntagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretion
ChEMBL 541 7 2 5 4.1 O=C(CN1C(=O)N(CC(=O)N2CCCC2)c2ccccc2N(c2ccccc2)C1=O)Nc1cccc(C(=O)O)c1 10.1016/j.bmc.2007.12.047
CHEMBL259390 102718 0 None - 0 Rat 6.2 pKd = 6.2 Functional
Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretionAntagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretion
ChEMBL 541 7 2 5 4.1 O=C(CN1C(=O)N(CC(=O)N2CCCC2)c2ccccc2N(c2ccccc2)C1=O)Nc1cccc(C(=O)O)c1 10.1016/j.bmc.2007.12.047
443375 214385 45 None -4466 6 Rat 6.1 pKd = 6.1 Functional
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm051219x
CHEMBL9506 214385 45 None -4466 6 Rat 6.1 pKd = 6.1 Functional
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm051219x
11505870 79282 0 None - 0 Rat 6.1 pKd = 6.1 Functional
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 526 8 3 4 6.6 Cc1ccccc1-c1nc(CCC23CC4CC(CC(C4)C2)C3)c(C(=O)Nc2ccc(N(C)C)c(C(=O)O)c2)[nH]1 10.1021/jm0490686
CHEMBL199032 79282 0 None - 0 Rat 6.1 pKd = 6.1 Functional
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 526 8 3 4 6.6 Cc1ccccc1-c1nc(CCC23CC4CC(CC(C4)C2)C3)c(C(=O)Nc2ccc(N(C)C)c(C(=O)O)c2)[nH]1 10.1021/jm0490686
11613179 78563 0 None - 0 Rat 8.1 pKd = 8.1 Functional
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 511 7 3 3 7.1 Cc1cc(C)c(-c2nc(C(=O)Nc3cccc(C(=O)O)c3)c(CCC34CC5CC(CC(C5)C3)C4)[nH]2)c(C)c1 10.1021/jm0490686
CHEMBL196745 78563 0 None - 0 Rat 8.1 pKd = 8.1 Functional
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 511 7 3 3 7.1 Cc1cc(C)c(-c2nc(C(=O)Nc3cccc(C(=O)O)c3)c(CCC34CC5CC(CC(C5)C3)C4)[nH]2)c(C)c1 10.1021/jm0490686
11511706 79036 0 None - 0 Rat 7.1 pKd = 7.1 Functional
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 501 7 3 3 6.6 Cc1ccccc1-c1nc(C(=O)Nc2ccc(F)c(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
CHEMBL198225 79036 0 None - 0 Rat 7.1 pKd = 7.1 Functional
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 501 7 3 3 6.6 Cc1ccccc1-c1nc(C(=O)Nc2ccc(F)c(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
136036821 102583 0 None - 0 Rat 7.1 pKd = 7.1 Functional
Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretionAntagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretion
ChEMBL 602 9 2 7 5.6 CC(C)(C)C(=O)CN1C(=O)N(CCCC(=O)Nc2cccc(-c3nc(=O)o[nH]3)c2)C(=O)N(C2CCCCC2)c2ccccc21 10.1016/j.bmc.2007.12.047
CHEMBL258782 102583 0 None - 0 Rat 7.1 pKd = 7.1 Functional
Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretionAntagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretion
ChEMBL 602 9 2 7 5.6 CC(C)(C)C(=O)CN1C(=O)N(CCCC(=O)Nc2cccc(-c3nc(=O)o[nH]3)c2)C(=O)N(C2CCCCC2)c2ccccc21 10.1016/j.bmc.2007.12.047
11642370 146949 0 None - 0 Rat 6.1 pKd = 6.1 Functional
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 540 7 1 6 5.7 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-n3ccnc3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
CHEMBL380363 146949 0 None - 0 Rat 6.1 pKd = 6.1 Functional
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 540 7 1 6 5.7 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-n3ccnc3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
135610887 92217 0 None - 0 Rat 8.0 pKd = 8.0 Functional
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 558 7 2 7 4.8 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nc(=O)o[nH]3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL226583 92217 0 None - 0 Rat 8.0 pKd = 8.0 Functional
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 558 7 2 7 4.8 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nc(=O)o[nH]3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
16732909 92232 0 None - 0 Rat 8.0 pKd = 8.0 Functional
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 532 8 2 5 5.1 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL226673 92232 0 None - 0 Rat 8.0 pKd = 8.0 Functional
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 532 8 2 5 5.1 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
11663565 82971 0 None - 0 Rat 7.0 pKd = 7.0 Functional
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 517 7 1 5 5.5 CN(C)c1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
CHEMBL205831 82971 0 None - 0 Rat 7.0 pKd = 7.0 Functional
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 517 7 1 5 5.5 CN(C)c1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
9832467 151071 0 None - 1 Dog 7.9 pKi = 7.9 Functional
Displacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosaDisplacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosa
ChEMBL 477 7 3 4 5.9 O=C(O)c1cccc(NC(=O)c2nc(C3CCCCC3)[nH]c2COC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm070139l
CHEMBL390519 151071 0 None - 1 Dog 7.9 pKi = 7.9 Functional
Displacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosaDisplacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosa
ChEMBL 477 7 3 4 5.9 O=C(O)c1cccc(NC(=O)c2nc(C3CCCCC3)[nH]c2COC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm070139l
11527738 82764 0 None - 0 Dog 7.9 pKi = 7.9 Functional
Displacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosaDisplacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosa
ChEMBL 518 7 2 5 5.2 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL205455 82764 0 None - 0 Dog 7.9 pKi = 7.9 Functional
Displacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosaDisplacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosa
ChEMBL 518 7 2 5 5.2 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL2370598 216657 0 None - 0 Human 6.9 pKi = 6.9 Functional
Ability to displace specific binding of 0.2 nM [3H]Boc[Nle28,31]-CCK27-33 from guinea pig brain membranesAbility to displace specific binding of 0.2 nM [3H]Boc[Nle28,31]-CCK27-33 from guinea pig brain membranes
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCCNC(=O)C[C@@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc2ccc(OS(=O)(=O)O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccccc1)C(N)=O 10.1021/jm00126a007
16732164 150081 0 None - 0 Dog 8.6 pKi = 8.6 Functional
Displacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosaDisplacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosa
ChEMBL 571 8 2 6 5.5 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2ccc3ccn(CC(=O)O)c3c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL389711 150081 0 None - 0 Dog 8.6 pKi = 8.6 Functional
Displacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosaDisplacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosa
ChEMBL 571 8 2 6 5.5 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2ccc3ccn(CC(=O)O)c3c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
16732753 150764 0 None - 0 Dog 7.6 pKi = 7.6 Functional
Displacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosaDisplacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosa
ChEMBL 552 8 2 5 5.7 Cc1ccccc1C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL390276 150764 0 None - 0 Dog 7.6 pKi = 7.6 Functional
Displacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosaDisplacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosa
ChEMBL 552 8 2 5 5.7 Cc1ccccc1C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
16732019 92209 0 None - 0 Dog 8.5 pKi = 8.5 Functional
Displacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosaDisplacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosa
ChEMBL 542 7 2 7 4.6 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nn[nH]n3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL226533 92209 0 None - 0 Dog 8.5 pKi = 8.5 Functional
Displacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosaDisplacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosa
ChEMBL 542 7 2 7 4.6 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nn[nH]n3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
16733466 92292 0 None - 0 Dog 8.4 pKi = 8.4 Functional
Displacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosaDisplacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosa
ChEMBL 558 10 2 5 5.6 O=C(O)CCc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1021/jm070139l
CHEMBL227330 92292 0 None - 0 Dog 8.4 pKi = 8.4 Functional
Displacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosaDisplacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosa
ChEMBL 558 10 2 5 5.6 O=C(O)CCc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1021/jm070139l
135610887 92217 0 None - 0 Dog 8.4 pKi = 8.4 Functional
Displacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosaDisplacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosa
ChEMBL 558 7 2 7 4.8 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nc(=O)o[nH]3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL226583 92217 0 None - 0 Dog 8.4 pKi = 8.4 Functional
Displacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosaDisplacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosa
ChEMBL 558 7 2 7 4.8 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nc(=O)o[nH]3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
135423404 92287 0 None - 0 Dog 8.4 pKi = 8.4 Functional
Displacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosaDisplacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosa
ChEMBL 570 8 2 7 5.0 O=C(CN1N=C(C2CCCCC2)c2ccccc2N(CC(=O)C2CCCC2)C1=O)Nc1cccc(-c2noc(=O)[nH]2)c1 10.1021/jm070139l
CHEMBL227276 92287 0 None - 0 Dog 8.4 pKi = 8.4 Functional
Displacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosaDisplacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosa
ChEMBL 570 8 2 7 5.0 O=C(CN1N=C(C2CCCCC2)c2ccccc2N(CC(=O)C2CCCC2)C1=O)Nc1cccc(-c2noc(=O)[nH]2)c1 10.1021/jm070139l
16732020 92285 0 None - 0 Dog 8.3 pKi = 8.3 Functional
Displacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosaDisplacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosa
ChEMBL 571 8 2 8 4.7 CN(c1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1)c1nn[nH]n1 10.1021/jm070139l
CHEMBL227254 92285 0 None - 0 Dog 8.3 pKi = 8.3 Functional
Displacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosaDisplacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosa
ChEMBL 571 8 2 8 4.7 CN(c1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1)c1nn[nH]n1 10.1021/jm070139l
16733469 92293 0 None - 0 Dog 8.3 pKi = 8.3 Functional
Displacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosaDisplacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosa
ChEMBL 576 10 2 6 5.8 O=C(O)CSc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1021/jm070139l
CHEMBL227333 92293 0 None - 0 Dog 8.3 pKi = 8.3 Functional
Displacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosaDisplacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosa
ChEMBL 576 10 2 6 5.8 O=C(O)CSc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1021/jm070139l
16732909 92232 0 None - 0 Dog 8.3 pKi = 8.3 Functional
Displacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosaDisplacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosa
ChEMBL 532 8 2 5 5.1 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL226673 92232 0 None - 0 Dog 8.3 pKi = 8.3 Functional
Displacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosaDisplacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosa
ChEMBL 532 8 2 5 5.1 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
16732911 149994 0 None - 0 Dog 8.2 pKi = 8.2 Functional
Displacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosaDisplacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosa
ChEMBL 564 9 2 6 5.6 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(SCC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL389639 149994 0 None - 0 Dog 8.2 pKi = 8.2 Functional
Displacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosaDisplacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosa
ChEMBL 564 9 2 6 5.6 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(SCC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
16732163 148842 0 None - 0 Dog 8.2 pKi = 8.2 Functional
Displacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosaDisplacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosa
ChEMBL 544 9 2 5 5.2 O=C(O)Cc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1021/jm070139l
CHEMBL387948 148842 0 None - 0 Dog 8.2 pKi = 8.2 Functional
Displacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosaDisplacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosa
ChEMBL 544 9 2 5 5.2 O=C(O)Cc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1021/jm070139l
16731872 92224 0 None - 0 Dog 8.2 pKi = 8.2 Functional
Displacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosaDisplacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosa
ChEMBL 530 8 2 5 5.3 O=C(CN1N=C(C2CCCCC2)c2ccccc2N(CC(=O)C2CCCC2)C1=O)Nc1cccc(C(=O)O)c1 10.1021/jm070139l
CHEMBL226620 92224 0 None - 0 Dog 8.2 pKi = 8.2 Functional
Displacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosaDisplacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosa
ChEMBL 530 8 2 5 5.3 O=C(CN1N=C(C2CCCCC2)c2ccccc2N(CC(=O)C2CCCC2)C1=O)Nc1cccc(C(=O)O)c1 10.1021/jm070139l
5489450 6994 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8914862
894 6994 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8914862
4329839 7606 0 None 158 2 Human 7.5 pIC50 = 7.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8349705
861 7606 0 None 158 2 Human 7.5 pIC50 = 7.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8349705
2802894 9182 33 None -1 3 Rat 7.5 pIC50 = 7.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 435 3 2 2 4.9 Brc1ccc(cc1)NC(=O)N1NC(=O)[C@H]([C@@H]1c1ccccc1)c1ccccc1 21228869
3509 9182 33 None -1 3 Rat 7.5 pIC50 = 7.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 435 3 2 2 4.9 Brc1ccc(cc1)NC(=O)N1NC(=O)[C@H]([C@@H]1c1ccccc1)c1ccccc1 21228869
CHEMBL333081 9182 33 None -1 3 Rat 7.5 pIC50 = 7.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 435 3 2 2 4.9 Brc1ccc(cc1)NC(=O)N1NC(=O)[C@H]([C@@H]1c1ccccc1)c1ccccc1 21228869
3523 10154 0 None - 1 Rat 8.0 pIC50 = 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 554 11 3 6 2.9 COc1cccc(c1)N(C(=O)CNC(=O)Nc1cccc(c1)CCS(=O)(=O)O)CC(=O)N(c1ccccc1)C 10385255
5311414 10154 0 None - 1 Rat 8.0 pIC50 = 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 554 11 3 6 2.9 COc1cccc(c1)N(C(=O)CNC(=O)Nc1cccc(c1)CCS(=O)(=O)O)CC(=O)N(c1ccccc1)C 10385255
16168172 8552 0 None 158 2 Mouse 8.3 pIC50 = 8.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1975695
3559 8552 0 None 158 2 Mouse 8.3 pIC50 = 8.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1975695
104929 9000 9 None -1 3 Human 8.4 pIC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 7681836
3477 9000 9 None -1 3 Human 8.4 pIC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 7681836
879 9000 9 None -1 3 Human 8.4 pIC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 7681836
CHEMBL289498 9000 9 None -1 3 Human 8.4 pIC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 7681836
3084441 8176 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7681836
3725 8176 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7681836
11307323 8919 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 546 6 2 5 5.0 Brc1ccc(c(c1)NS(=O)(=O)c1cccc2c1nccn2)C(=O)N[C@@H](c1ccc(cc1F)F)C 21493750
6665 8919 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 546 6 2 5 5.0 Brc1ccc(c(c1)NS(=O)(=O)c1cccc2c1nccn2)C(=O)N[C@@H](c1ccc(cc1F)F)C 21493750
3948 9783 0 None - 1 Rat 9.1 pIC50 = 9.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8720482
5491702 9783 0 None - 1 Rat 9.1 pIC50 = 9.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8720482
444007 9817 0 None 794 2 Mouse 9.1 pIC50 = 9.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1975695
870 9817 0 None 794 2 Mouse 9.1 pIC50 = 9.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1975695
DB00183 9817 0 None 794 2 Mouse 9.1 pIC50 = 9.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1975695
132980 9020 12 None 6456 2 Human 9.2 pIC50 = 9.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 445 2 2 4 4.0 Cc1cccc(c1)NC(=O)N[C@@H]1N=C(N2CC3CCC(C2)CC3)c2c(N(C1=O)C)cccc2 11738246
881 9020 12 None 6456 2 Human 9.2 pIC50 = 9.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 445 2 2 4 4.0 Cc1cccc(c1)NC(=O)N[C@@H]1N=C(N2CC3CCC(C2)CC3)c2c(N(C1=O)C)cccc2 11738246
CHEMBL420783 9020 12 None 6456 2 Human 9.2 pIC50 = 9.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 445 2 2 4 4.0 Cc1cccc(c1)NC(=O)N[C@@H]1N=C(N2CC3CCC(C2)CC3)c2c(N(C1=O)C)cccc2 11738246
122130 10887 39 None -5 4 Human 9.2 pIC50 = 9.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 516 6 2 4 5.5 Cc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccc2)c2c(N(C1=O)CC(=O)c1ccccc1C)cccc2 11738246
888 10887 39 None -5 4 Human 9.2 pIC50 = 9.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 516 6 2 4 5.5 Cc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccc2)c2c(N(C1=O)CC(=O)c1ccccc1C)cccc2 11738246
CHEMBL115121 10887 39 None -5 4 Human 9.2 pIC50 = 9.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 516 6 2 4 5.5 Cc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccc2)c2c(N(C1=O)CC(=O)c1ccccc1C)cccc2 11738246
3503 8674 16 None - 1 Human 9.4 pIC50 = 9.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 534 5 2 3 6.1 O=C(N[C@H]1C(=O)N(c2ccccc2)c2c(N(C1=O)CC13CC4CC(C3)CC(C1)C4)cccc2)Nc1ccccc1 11020274
5311147 8674 16 None - 1 Human 9.4 pIC50 = 9.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 534 5 2 3 6.1 O=C(N[C@H]1C(=O)N(c2ccccc2)c2c(N(C1=O)CC13CC4CC(C3)CC(C1)C4)cccc2)Nc1ccccc1 11020274
CHEMBL329305 8674 16 None - 1 Human 9.4 pIC50 = 9.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 534 5 2 3 6.1 O=C(N[C@H]1C(=O)N(c2ccccc2)c2c(N(C1=O)CC13CC4CC(C3)CC(C1)C4)cccc2)Nc1ccccc1 11020274
862 7607 0 None 1 2 Mouse 9.5 pIC50 = 9.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 12370550
887 10882 33 None -1 3 Human 9.7 pIC50 = 9.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 22607579
887 10882 33 None -1 3 Human 9.7 pIC50 = 9.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 9042983
9870520 10882 33 None -1 3 Human 9.7 pIC50 = 9.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 22607579
9870520 10882 33 None -1 3 Human 9.7 pIC50 = 9.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 9042983
CHEMBL324547 10882 33 None -1 3 Human 9.7 pIC50 = 9.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 22607579
CHEMBL324547 10882 33 None -1 3 Human 9.7 pIC50 = 9.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 9042983
DB12355 10882 33 None -1 3 Human 9.7 pIC50 = 9.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 22607579
DB12355 10882 33 None -1 3 Human 9.7 pIC50 = 9.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 9042983
44457632 9801 0 None - 1 Mouse 10.1 pIC50 None 10.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 575 10 4 4 5.4 OC(=O)CC(NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccc(cc1)F 8931944
905 9801 0 None - 1 Mouse 10.1 pIC50 None 10.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 575 10 4 4 5.4 OC(=O)CC(NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccc(cc1)F 8931944
3960 9124 23 None -131 4 Human 5.5 pIC50 None 5.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 458 14 2 3 5.2 CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCCC 8914862
891 9124 23 None -131 4 Human 5.5 pIC50 None 5.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 458 14 2 3 5.2 CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCCC 8914862
CHEMBL24938 9124 23 None -131 4 Human 5.5 pIC50 None 5.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 458 14 2 3 5.2 CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCCC 8914862
5311148 8677 7 None -41 2 Human 6.0 pIC50 None 6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 587 8 1 5 5.9 COc1ccc(cc1)N(C(=O)CN1C(=O)C(Cc2[nH]nc3c2cccc3)C(=O)N(c2c1cccc2)c1ccccc1)C(C)C 9276016
865 8677 7 None -41 2 Human 6.0 pIC50 None 6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 587 8 1 5 5.9 COc1ccc(cc1)N(C(=O)CN1C(=O)C(Cc2[nH]nc3c2cccc3)C(=O)N(c2c1cccc2)c1ccccc1)C(C)C 9276016
CHEMBL293226 8677 7 None -41 2 Human 6.0 pIC50 None 6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 587 8 1 5 5.9 COc1ccc(cc1)N(C(=O)CN1C(=O)C(Cc2[nH]nc3c2cccc3)C(=O)N(c2c1cccc2)c1ccccc1)C(C)C 9276016
904 9800 10 None -44 3 Rat 6.6 pIC50 None 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 557 10 4 4 5.2 OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 7684452
9915756 9800 10 None -44 3 Rat 6.6 pIC50 None 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 557 10 4 4 5.2 OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 7684452
CHEMBL2111204 9800 10 None -44 3 Rat 6.6 pIC50 None 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 557 10 4 4 5.2 OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 7684452
CHEMBL356898 9800 10 None -44 3 Rat 6.6 pIC50 None 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 557 10 4 4 5.2 OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 7684452
54695534 10561 5 None -54 2 Human 6.7 pIC50 None 6.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 570 2 3 8 4.5 OC1C/C=C/CC(C)C2C(SCC2C(=O)C2=C(OC3(C(C/C=C/C=C/C1)C=C(C)C(C3)C)C2=O)O)C(=O)C(=O)O 8233061
910 10561 5 None -54 2 Human 6.7 pIC50 None 6.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 570 2 3 8 4.5 OC1C/C=C/CC(C)C2C(SCC2C(=O)C2=C(OC3(C(C/C=C/C=C/C1)C=C(C)C(C3)C)C2=O)O)C(=O)C(=O)O 8233061
CHEMBL3576924 10561 5 None -54 2 Human 6.7 pIC50 None 6.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 570 2 3 8 4.5 OC1C/C=C/CC(C)C2C(SCC2C(=O)C2=C(OC3(C(C/C=C/C=C/C1)C=C(C)C(C3)C)C2=O)O)C(=O)C(=O)O 8233061
3476 8182 9 None -870 2 Human 6.8 pIC50 None 6.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 408 3 2 3 3.7 O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 7681836
59751 8182 9 None -870 2 Human 6.8 pIC50 None 6.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 408 3 2 3 3.7 O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 7681836
878 8182 9 None -870 2 Human 6.8 pIC50 None 6.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 408 3 2 3 3.7 O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 7681836
CHEMBL39263 8182 9 None -870 2 Human 6.8 pIC50 None 6.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 408 3 2 3 3.7 O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 7681836
6956374 9184 5 None 3 3 Human 7.0 pIC50 None 7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 435 3 2 2 4.9 Brc1ccc(cc1)NC(=O)N1NC(=O)[C@@H]([C@H]1c1ccccc1)c1ccccc1 8914862
902 9184 5 None 3 3 Human 7.0 pIC50 None 7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 435 3 2 2 4.9 Brc1ccc(cc1)NC(=O)N1NC(=O)[C@@H]([C@H]1c1ccccc1)c1ccccc1 8914862
CHEMBL117281 9184 5 None 3 3 Human 7.0 pIC50 None 7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 435 3 2 2 4.9 Brc1ccc(cc1)NC(=O)N1NC(=O)[C@@H]([C@H]1c1ccccc1)c1ccccc1 8914862
898 8906 0 None - 1 Rat 8.4 pIC50 None 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1698251
3074331 7712 0 None - 1 Mouse 8.5 pIC50 None 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 493 6 4 4 4.6 O=C(N[C@@](C(=O)N[C@H]1CCCC[C@@H]1O)(Cc1c[nH]c2c1cccc2)C)OC12CC3CC(C2)CC(C1)C3 9438020
872 7712 0 None - 1 Mouse 8.5 pIC50 None 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 493 6 4 4 4.6 O=C(N[C@@](C(=O)N[C@H]1CCCC[C@@H]1O)(Cc1c[nH]c2c1cccc2)C)OC12CC3CC(C2)CC(C1)C3 9438020
6604121 8886 23 None 15848 2 Rat 8.6 pIC50 None 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 526 7 2 3 6.8 OC(=O)C[C@H](c1cccc2c1cccc2)CC(=O)Nc1c(C)cc(cc1C(=O)N1CCC2(CC1)CCCC2)C 10204685
909 8886 23 None 15848 2 Rat 8.6 pIC50 None 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 526 7 2 3 6.8 OC(=O)C[C@H](c1cccc2c1cccc2)CC(=O)Nc1c(C)cc(cc1C(=O)N1CCC2(CC1)CCCC2)C 10204685
CHEMBL1256717 8886 23 None 15848 2 Rat 8.6 pIC50 None 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 526 7 2 3 6.8 OC(=O)C[C@H](c1cccc2c1cccc2)CC(=O)Nc1c(C)cc(cc1C(=O)N1CCC2(CC1)CCCC2)C 10204685
16129670 7603 0 None - 1 Human 8.8 pIC50 None 8.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8349705
860 7603 0 None - 1 Human 8.8 pIC50 None 8.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8349705
91898395 7603 0 None - 1 Human 8.8 pIC50 None 8.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8349705
108187 7713 37 None -67 5 Mouse 8.8 pIC50 None 8.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 1975695
873 7713 37 None -67 5 Mouse 8.8 pIC50 None 8.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 1975695
CHEMBL2062154 7713 37 None -67 5 Mouse 8.8 pIC50 None 8.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 1975695
CHEMBL287735 7713 37 None -67 5 Mouse 8.8 pIC50 None 8.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 1975695
122119 9797 0 None 1000 2 Human 8.9 pIC50 None 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 618 12 5 6 5.1 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](CC1CNc2c1cccc2)(NC(=O)OC1C[C@H]2C([C@]1(C)CC2)(C)C)C)CCC(=O)O 8914862
882 9797 0 None 1000 2 Human 8.9 pIC50 None 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 618 12 5 6 5.1 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](CC1CNc2c1cccc2)(NC(=O)OC1C[C@H]2C([C@]1(C)CC2)(C)C)C)CCC(=O)O 8914862
108187 7713 37 None 67 5 Human 9.1 pIC50 None 9.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 8914862
873 7713 37 None 67 5 Human 9.1 pIC50 None 9.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 8914862
CHEMBL2062154 7713 37 None 67 5 Human 9.1 pIC50 None 9.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 8914862
CHEMBL287735 7713 37 None 67 5 Human 9.1 pIC50 None 9.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 8914862
5311016 7379 0 None - 1 Rat 9.5 pIC50 None 9.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 14698161
897 7379 0 None - 1 Rat 9.5 pIC50 None 9.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 14698161
903 9798 9 None 123 2 Mouse 9.8 pIC50 None 9.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 557 10 4 4 5.2 OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 8605955
9850711 9798 9 None 123 2 Mouse 9.8 pIC50 None 9.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 557 10 4 4 5.2 OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 8605955
CHEMBL138534 9798 9 None 123 2 Mouse 9.8 pIC50 None 9.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 557 10 4 4 5.2 OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 8605955
CHEMBL2111312 9798 9 None 123 2 Mouse 9.8 pIC50 None 9.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 557 10 4 4 5.2 OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 8605955
4627 7609 50 None -1 6 Human 10.0 pIC50 None 10.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7681836
4627 7609 50 None -1 6 Human 10.0 pIC50 None 10.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8349705
864 7609 50 None -1 6 Human 10.0 pIC50 None 10.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7681836
864 7609 50 None -1 6 Human 10.0 pIC50 None 10.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8349705
9833444 7609 50 None -1 6 Human 10.0 pIC50 None 10.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7681836
9833444 7609 50 None -1 6 Human 10.0 pIC50 None 10.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8349705
CHEMBL1121 7609 50 None -1 6 Human 10.0 pIC50 None 10.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7681836
CHEMBL1121 7609 50 None -1 6 Human 10.0 pIC50 None 10.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8349705
DB09142 7609 50 None -1 6 Human 10.0 pIC50 None 10.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7681836
DB09142 7609 50 None -1 6 Human 10.0 pIC50 None 10.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8349705




Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
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DOI

41684 37995 105 None - 0 Human 5.0 pAC50 = 5 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 307 4 1 7 2.2 CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1 10.1038/s41467-023-40064-9
CHEMBL1401 37995 105 None - 0 Human 5.0 pAC50 = 5 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 307 4 1 7 2.2 CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1 10.1038/s41467-023-40064-9
4494 196966 87 None - 0 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 385 5 1 8 2.5 COC(=O)C1=C(C#N)NC(C)=C(C(=O)OC(C)C)C1c1cccc([N+](=O)[O-])c1 10.1038/s41467-023-40064-9
CHEMBL517427 196966 87 None - 0 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 385 5 1 8 2.5 COC(=O)C1=C(C#N)NC(C)=C(C(=O)OC(C)C)C1c1cccc([N+](=O)[O-])c1 10.1038/s41467-023-40064-9
6479523 53216 48 None - 0 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 461 5 4 6 0.1 CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](NC(=O)N3CCNC3=O)c3ccccc3)C(=O)N2[C@H]1C(=O)O 10.1038/s41467-023-40064-9
CHEMBL1537 53216 48 None - 0 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 461 5 4 6 0.1 CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](NC(=O)N3CCNC3=O)c3ccccc3)C(=O)N2[C@H]1C(=O)O 10.1038/s41467-023-40064-9
6436173 61890 45 None - 0 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 785 2 5 13 6.2 CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c5c(nc6cc(C)ccn65)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C 10.1038/s41467-023-40064-9
CHEMBL1617 61890 45 None - 0 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 785 2 5 13 6.2 CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c5c(nc6cc(C)ccn65)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C 10.1038/s41467-023-40064-9
3899 214553 119 None - 0 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 270 2 1 3 3.3 Cc1oncc1C(=O)Nc1ccc(C(F)(F)F)cc1 10.1038/s41467-023-40064-9
CHEMBL960 214553 119 None - 0 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 270 2 1 3 3.3 Cc1oncc1C(=O)Nc1ccc(C(F)(F)F)cc1 10.1038/s41467-023-40064-9
148124 213878 86 None - 1 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 807 8 5 14 3.3 CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@@H]12)C3(C)C 10.1038/s41467-023-40064-9
CHEMBL3545252 213878 86 None - 1 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 807 8 5 14 3.3 CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@@H]12)C3(C)C 10.1038/s41467-023-40064-9
CHEMBL92 213878 86 None - 1 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 807 8 5 14 3.3 CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@@H]12)C3(C)C 10.1038/s41467-023-40064-9
3883 190314 112 None - 0 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 369 5 1 4 3.5 Cc1c(OCC(F)(F)F)ccnc1C[S+]([O-])c1nc2ccccc2[nH]1 10.1038/s41467-023-40064-9
CHEMBL480 190314 112 None - 0 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 369 5 1 4 3.5 Cc1c(OCC(F)(F)F)ccnc1C[S+]([O-])c1nc2ccccc2[nH]1 10.1038/s41467-023-40064-9
50922675 119361 54 None - 0 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 539 9 3 9 3.9 COC(=O)N[C@@H](C)CNc1nccc(-c2cn(C(C)C)nc2-c2cc(Cl)cc(NS(C)(=O)=O)c2F)n1 10.1038/s41467-023-40064-9
CHEMBL3301612 119361 54 None - 0 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 539 9 3 9 3.9 COC(=O)N[C@@H](C)CNc1nccc(-c2cn(C(C)C)nc2-c2cc(Cl)cc(NS(C)(=O)=O)c2F)n1 10.1038/s41467-023-40064-9
228 7233 28 None - 23 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 10.1038/s41467-023-40064-9
33 7233 28 None - 23 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 10.1038/s41467-023-40064-9
6005 7233 28 None - 23 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 10.1038/s41467-023-40064-9
CHEMBL53 7233 28 None - 23 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 10.1038/s41467-023-40064-9
DB00714 7233 28 None - 23 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 10.1038/s41467-023-40064-9
40973 52809 70 None - 0 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 310 1 1 1 4.9 C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3C(=C)C[C@@]21CC 10.1038/s41467-023-40064-9
CHEMBL1533 52809 70 None - 0 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 310 1 1 1 4.9 C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3C(=C)C[C@@]21CC 10.1038/s41467-023-40064-9
3401 85058 80 None - 0 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 346 4 0 2 5.0 Fc1ccc(C(c2ccccc2)(c2ccccc2F)n2ccnc2)cc1 10.1038/s41467-023-40064-9
CHEMBL2107430 85058 80 None - 0 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 346 4 0 2 5.0 Fc1ccc(C(c2ccccc2)(c2ccccc2F)n2ccnc2)cc1 10.1038/s41467-023-40064-9
1016 10519 78 None - 35 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 10.1038/s41467-023-40064-9
2561 10519 78 None - 35 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 10.1038/s41467-023-40064-9
2733526 10519 78 None - 35 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 10.1038/s41467-023-40064-9
5384 10519 78 None - 35 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL83 10519 78 None - 35 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 10.1038/s41467-023-40064-9
DB00675 10519 78 None - 35 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 10.1038/s41467-023-40064-9
2812 11551 101 None - 34 Human 4.5 pAC50 = 4.5 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 10.1038/s41467-023-40064-9
CHEMBL104 11551 101 None - 34 Human 4.5 pAC50 = 4.5 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 10.1038/s41467-023-40064-9
104850 10103 96 None - 6 Human 4.5 pAC50 = 4.5 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 462 4 1 4 5.9 Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 10.1038/s41467-023-40064-9
4150 10103 96 None - 6 Human 4.5 pAC50 = 4.5 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 462 4 1 4 5.9 Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 10.1038/s41467-023-40064-9
743 10103 96 None - 6 Human 4.5 pAC50 = 4.5 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 462 4 1 4 5.9 Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 10.1038/s41467-023-40064-9
CHEMBL111 10103 96 None - 6 Human 4.5 pAC50 = 4.5 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 462 4 1 4 5.9 Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 10.1038/s41467-023-40064-9
DB06155 10103 96 None - 6 Human 4.5 pAC50 = 4.5 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 462 4 1 4 5.9 Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 10.1038/s41467-023-40064-9
2540 11173 111 None - 4 Human 4.5 pAC50 = 4.5 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 610 10 1 11 6.3 CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1038/s41467-023-40064-9
CHEMBL1014 11173 111 None - 4 Human 4.5 pAC50 = 4.5 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 610 10 1 11 6.3 CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1038/s41467-023-40064-9
3784 63946 101 None - 0 Human 4.5 pAC50 = 4.5 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 371 4 1 8 2.6 COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)C)C1c1cccc2nonc12 10.1038/s41467-023-40064-9
CHEMBL1648 63946 101 None - 0 Human 4.5 pAC50 = 4.5 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 371 4 1 8 2.6 COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)C)C1c1cccc2nonc12 10.1038/s41467-023-40064-9
64139 91560 96 None - 0 Human 4.4 pAC50 = 4.4 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 315 0 1 2 4.1 O=C1Nc2ccc(Cl)cc2[C@@](C#CC2CC2)(C(F)(F)F)O1 10.1038/s41467-023-40064-9
CHEMBL223228 91560 96 None - 0 Human 4.4 pAC50 = 4.4 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 315 0 1 2 4.1 O=C1Nc2ccc(Cl)cc2[C@@](C#CC2CC2)(C(F)(F)F)O1 10.1038/s41467-023-40064-9
3380 29562 34 None - 1 Human 4.3 pAC50 = 4.3 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 313 2 0 4 2.5 CN1C(=O)CN=C(c2ccccc2F)c2cc([N+](=O)[O-])ccc21 10.1038/s41467-023-40064-9
CHEMBL13280 29562 34 None - 1 Human 4.3 pAC50 = 4.3 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 313 2 0 4 2.5 CN1C(=O)CN=C(c2ccccc2F)c2cc([N+](=O)[O-])ccc21 10.1038/s41467-023-40064-9
2194 69857 101 None - 0 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 240 2 0 4 4.2 COc1ccc(-c2cc(=S)ss2)cc1 10.1038/s41467-023-40064-9
CHEMBL178862 69857 101 None - 0 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 240 2 0 4 4.2 COc1ccc(-c2cc(=S)ss2)cc1 10.1038/s41467-023-40064-9
1209 8439 75 None - 32 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F 10.1038/s41467-023-40064-9
203 8439 75 None - 32 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F 10.1038/s41467-023-40064-9
3386 8439 75 None - 32 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F 10.1038/s41467-023-40064-9
CHEMBL41 8439 75 None - 32 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F 10.1038/s41467-023-40064-9
DB00472 8439 75 None - 32 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F 10.1038/s41467-023-40064-9
10034073 23933 29 None - 0 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 1056 13 7 18 6.2 CCc1c(Cl)c(O)c(Cl)c(O)c1C(=O)O[C@H]1[C@H](O)[C@H](OC)[C@H](OC/C2=C\C=C\C[C@H](O)/C(C)=C/[C@H](CC)[C@@H](O[C@@H]3OC(C)(C)[C@@H](OC(=O)C(C)C)[C@H](O)[C@@H]3O)/C(C)=C/C(C)=C/C[C@@H]([C@@H](C)O)OC2=O)O[C@@H]1C 10.1038/s41467-023-40064-9
CHEMBL1255800 23933 29 None - 0 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 1056 13 7 18 6.2 CCc1c(Cl)c(O)c(Cl)c(O)c1C(=O)O[C@H]1[C@H](O)[C@H](OC)[C@H](OC/C2=C\C=C\C[C@H](O)/C(C)=C/[C@H](CC)[C@@H](O[C@@H]3OC(C)(C)[C@@H](OC(=O)C(C)C)[C@H](O)[C@@H]3O)/C(C)=C/C(C)=C/C[C@@H]([C@@H](C)O)OC2=O)O[C@@H]1C 10.1038/s41467-023-40064-9
135564886 21265 5 None - 0 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
135673376 21265 5 None - 0 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
137157436 21265 5 None - 0 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
145948239 21265 5 None - 0 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
71587099 21265 5 None - 0 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
CHEMBL1201304 21265 5 None - 0 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
3294 8787 111 None -323 44 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C 10.1038/s41467-023-40064-9
71360 8787 111 None -323 44 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C 10.1038/s41467-023-40064-9
87 8787 111 None -323 44 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C 10.1038/s41467-023-40064-9
CHEMBL14376 8787 111 None -323 44 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C 10.1038/s41467-023-40064-9
DB04946 8787 111 None -323 44 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C 10.1038/s41467-023-40064-9
4627 7609 50 None -1 5 Human 10.3 pEC50 = 10.3 Binding
Compound was evaluated for the [Ca2+] mobilization innstably transfected CHO-K1 cell lines expressing human Cholecystokinin type B receptorCompound was evaluated for the [Ca2+] mobilization innstably transfected CHO-K1 cell lines expressing human Cholecystokinin type B receptor
ChEMBL None None None None 10.1021/jm00017a022
864 7609 50 None -1 5 Human 10.3 pEC50 = 10.3 Binding
Compound was evaluated for the [Ca2+] mobilization innstably transfected CHO-K1 cell lines expressing human Cholecystokinin type B receptorCompound was evaluated for the [Ca2+] mobilization innstably transfected CHO-K1 cell lines expressing human Cholecystokinin type B receptor
ChEMBL None None None None 10.1021/jm00017a022
9833444 7609 50 None -1 5 Human 10.3 pEC50 = 10.3 Binding
Compound was evaluated for the [Ca2+] mobilization innstably transfected CHO-K1 cell lines expressing human Cholecystokinin type B receptorCompound was evaluated for the [Ca2+] mobilization innstably transfected CHO-K1 cell lines expressing human Cholecystokinin type B receptor
ChEMBL None None None None 10.1021/jm00017a022
CHEMBL1121 7609 50 None -1 5 Human 10.3 pEC50 = 10.3 Binding
Compound was evaluated for the [Ca2+] mobilization innstably transfected CHO-K1 cell lines expressing human Cholecystokinin type B receptorCompound was evaluated for the [Ca2+] mobilization innstably transfected CHO-K1 cell lines expressing human Cholecystokinin type B receptor
ChEMBL None None None None 10.1021/jm00017a022
DB09142 7609 50 None -1 5 Human 10.3 pEC50 = 10.3 Binding
Compound was evaluated for the [Ca2+] mobilization innstably transfected CHO-K1 cell lines expressing human Cholecystokinin type B receptorCompound was evaluated for the [Ca2+] mobilization innstably transfected CHO-K1 cell lines expressing human Cholecystokinin type B receptor
ChEMBL None None None None 10.1021/jm00017a022
4627 7609 50 None -1 5 Human 10.0 pEC50 = 10.0 Binding
Displacement of [125I]CCK-8 from CCK2 receptor in human FGS7 Jurkat cellsDisplacement of [125I]CCK-8 from CCK2 receptor in human FGS7 Jurkat cells
ChEMBL None None None None 10.1021/np058114h
864 7609 50 None -1 5 Human 10.0 pEC50 = 10.0 Binding
Displacement of [125I]CCK-8 from CCK2 receptor in human FGS7 Jurkat cellsDisplacement of [125I]CCK-8 from CCK2 receptor in human FGS7 Jurkat cells
ChEMBL None None None None 10.1021/np058114h
9833444 7609 50 None -1 5 Human 10.0 pEC50 = 10.0 Binding
Displacement of [125I]CCK-8 from CCK2 receptor in human FGS7 Jurkat cellsDisplacement of [125I]CCK-8 from CCK2 receptor in human FGS7 Jurkat cells
ChEMBL None None None None 10.1021/np058114h
CHEMBL1121 7609 50 None -1 5 Human 10.0 pEC50 = 10.0 Binding
Displacement of [125I]CCK-8 from CCK2 receptor in human FGS7 Jurkat cellsDisplacement of [125I]CCK-8 from CCK2 receptor in human FGS7 Jurkat cells
ChEMBL None None None None 10.1021/np058114h
DB09142 7609 50 None -1 5 Human 10.0 pEC50 = 10.0 Binding
Displacement of [125I]CCK-8 from CCK2 receptor in human FGS7 Jurkat cellsDisplacement of [125I]CCK-8 from CCK2 receptor in human FGS7 Jurkat cells
ChEMBL None None None None 10.1021/np058114h
CHEMBL413654 219858 0 None 2 2 Rat 6.0 pEC50 = 6 Binding
Tested for the 50% inhibition level against [125I]- gastrin binding in AR42J cellsTested for the 50% inhibition level against [125I]- gastrin binding in AR42J cells
ChEMBL None None None CSCC[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@H](CC(=O)O)C(=O)N[C@H](Cc1ccccc1)C(N)=O 10.1021/jm00048a016
10260074 113400 0 None - 0 Human 6.9 pEC50 = 6.9 Binding
Tested for the 50% inhibition level against [125I]- gastrin binding to guinea pig gastric glandsTested for the 50% inhibition level against [125I]- gastrin binding to guinea pig gastric glands
ChEMBL 875 25 7 10 3.0 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCC(=O)N(Cc1ccccc1)N=NCCCl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00048a016
CHEMBL3143010 113400 0 None - 0 Human 6.9 pEC50 = 6.9 Binding
Tested for the 50% inhibition level against [125I]- gastrin binding to guinea pig gastric glandsTested for the 50% inhibition level against [125I]- gastrin binding to guinea pig gastric glands
ChEMBL 875 25 7 10 3.0 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCC(=O)N(Cc1ccccc1)N=NCCCl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00048a016
162661486 188242 0 None - 0 Human 7.8 pEC50 = 7.8 Binding
Agonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 minsAgonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 mins
ChEMBL 5678 175 68 78 -9.6 CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CSC2CC(=O)N(CCC(=O)NC(C(=O)NCCCCCCNC(=O)COCCOCCNC(=O)CCC(NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)CCCCNC(=O)CCN3C(=O)CC(SC[C@H](NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc4c[nH]cn4)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N1)C3=O)C2=O)[C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.0c00736
CHEMBL4764500 188242 0 None - 0 Human 7.8 pEC50 = 7.8 Binding
Agonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 minsAgonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 mins
ChEMBL 5678 175 68 78 -9.6 CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CSC2CC(=O)N(CCC(=O)NC(C(=O)NCCCCCCNC(=O)COCCOCCNC(=O)CCC(NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)CCCCNC(=O)CCN3C(=O)CC(SC[C@H](NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc4c[nH]cn4)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N1)C3=O)C2=O)[C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.0c00736
162661520 188308 0 None - 0 Human 7.8 pEC50 = 7.8 Binding
Agonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 minsAgonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 mins
ChEMBL 5663 173 67 77 -8.6 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc2c[nH]cn2)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)CSC2CC(=O)N(CCC(=O)NCCCCC(C(=O)NCCCCCCNC(=O)COCCOCCNC(=O)CCC(NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)NC(=O)CCN3C(=O)CC(SC[C@@H](C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)N[C@@H](Cc4ccc(O)cc4)C(=O)NCC(=O)N[C@@H](Cc4c[nH]c5ccccc45)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc4ccccc4)C(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCC(=O)O)NC1=O)C3=O)C2=O 10.1021/acs.jmedchem.0c00736
CHEMBL4765166 188308 0 None - 0 Human 7.8 pEC50 = 7.8 Binding
Agonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 minsAgonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 mins
ChEMBL 5663 173 67 77 -8.6 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc2c[nH]cn2)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)CSC2CC(=O)N(CCC(=O)NCCCCC(C(=O)NCCCCCCNC(=O)COCCOCCNC(=O)CCC(NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)NC(=O)CCN3C(=O)CC(SC[C@@H](C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)N[C@@H](Cc4ccc(O)cc4)C(=O)NCC(=O)N[C@@H](Cc4c[nH]c5ccccc45)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc4ccccc4)C(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCC(=O)O)NC1=O)C3=O)C2=O 10.1021/acs.jmedchem.0c00736
10032955 174814 0 None - 0 Human 5.6 pEC50 = 5.6 Binding
Compound was evaluated for the [Ca2+] mobilization innstably transfected CHO-K1 cell lines expressing human Cholecystokinin type B receptorCompound was evaluated for the [Ca2+] mobilization innstably transfected CHO-K1 cell lines expressing human Cholecystokinin type B receptor
ChEMBL 742 17 7 6 5.8 Cc1ccccc1NC(=O)NCCCC[C@H](CNC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3)NC(=O)CCC(=O)O 10.1021/jm00017a022
CHEMBL432256 174814 0 None - 0 Human 5.6 pEC50 = 5.6 Binding
Compound was evaluated for the [Ca2+] mobilization innstably transfected CHO-K1 cell lines expressing human Cholecystokinin type B receptorCompound was evaluated for the [Ca2+] mobilization innstably transfected CHO-K1 cell lines expressing human Cholecystokinin type B receptor
ChEMBL 742 17 7 6 5.8 Cc1ccccc1NC(=O)NCCCC[C@H](CNC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3)NC(=O)CCC(=O)O 10.1021/jm00017a022
CHEMBL319438 217996 0 None - 0 Human 6.3 pEC50 = 6.3 Binding
Compound was evaluated for the [Ca2+] mobilization in stably transfected CHO-K1 cell lines expressing human Cholecystokinin type B receptorCompound was evaluated for the [Ca2+] mobilization in stably transfected CHO-K1 cell lines expressing human Cholecystokinin type B receptor
ChEMBL None None None CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00017a022
162668747 189398 0 None - 0 Human 8.1 pEC50 = 8.1 Binding
Agonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 minsAgonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 mins
ChEMBL 6123 176 72 84 -13.9 CCCCCCCCCCCCCCCC(=O)NCCCCCCNC(=O)C1CCCCNC(=O)CCN2C(=O)CC(SC[C@H](NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc3c[nH]cn3)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N3CCC[C@H]3C(=O)N3CCC[C@H]3C(=O)N3CCC[C@H]3C(=O)N[C@@H](CO)C(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)NCC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc3ccccc3)C(N)=O)[C@@H](C)CC)[C@@H](C)CC)CSC3CC(=O)N(CCC(=O)N1)C3=O)C2=O 10.1021/acs.jmedchem.0c00736
CHEMBL4788440 189398 0 None - 0 Human 8.1 pEC50 = 8.1 Binding
Agonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 minsAgonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 mins
ChEMBL 6123 176 72 84 -13.9 CCCCCCCCCCCCCCCC(=O)NCCCCCCNC(=O)C1CCCCNC(=O)CCN2C(=O)CC(SC[C@H](NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc3c[nH]cn3)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N3CCC[C@H]3C(=O)N3CCC[C@H]3C(=O)N3CCC[C@H]3C(=O)N[C@@H](CO)C(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)NCC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc3ccccc3)C(N)=O)[C@@H](C)CC)[C@@H](C)CC)CSC3CC(=O)N(CCC(=O)N1)C3=O)C2=O 10.1021/acs.jmedchem.0c00736
162662538 188803 0 None - 0 Human 8.1 pEC50 = 8.1 Binding
Agonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 minsAgonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 mins
ChEMBL 5436 173 70 79 -19.4 CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CS)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)[C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)N[C@@H](Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.0c00736
CHEMBL4780789 188803 0 None - 0 Human 8.1 pEC50 = 8.1 Binding
Agonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 minsAgonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 mins
ChEMBL 5436 173 70 79 -19.4 CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CS)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)[C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)N[C@@H](Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.0c00736
162665647 189142 0 None - 0 Human 8.1 pEC50 = 8.1 Binding
Agonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 minsAgonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 mins
ChEMBL 5421 171 69 78 -18.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CS)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)N[C@@H](Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)[C@@H](C)CC 10.1021/acs.jmedchem.0c00736
CHEMBL4784851 189142 0 None - 0 Human 8.1 pEC50 = 8.1 Binding
Agonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 minsAgonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 mins
ChEMBL 5421 171 69 78 -18.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CS)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)N[C@@H](Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)[C@@H](C)CC 10.1021/acs.jmedchem.0c00736
162665440 189039 0 None - 0 Human 8.1 pEC50 = 8.1 Binding
Agonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 minsAgonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 mins
ChEMBL 5338 170 70 76 -18.6 CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CS)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)[C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.0c00736
CHEMBL4783736 189039 0 None - 0 Human 8.1 pEC50 = 8.1 Binding
Agonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 minsAgonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 mins
ChEMBL 5338 170 70 76 -18.6 CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CS)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)[C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.0c00736
162673451 189968 0 None - 0 Human 8.1 pEC50 = 8.1 Binding
Agonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 minsAgonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 mins
ChEMBL 6108 174 71 83 -13.0 CCCCCCCCCCCCCCCC(=O)NCCCCCCNC(=O)C1CCCCNC(=O)CCN2C(=O)CC(SC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc3c[nH]cn3)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N3CCC[C@H]3C(=O)N3CCC[C@H]3C(=O)N3CCC[C@H]3C(=O)N[C@@H](CO)C(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)NCC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc3ccccc3)C(N)=O)CSC3CC(=O)N(CCC(=O)N1)C3=O)C2=O 10.1021/acs.jmedchem.0c00736
CHEMBL4795718 189968 0 None - 0 Human 8.1 pEC50 = 8.1 Binding
Agonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 minsAgonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 mins
ChEMBL 6108 174 71 83 -13.0 CCCCCCCCCCCCCCCC(=O)NCCCCCCNC(=O)C1CCCCNC(=O)CCN2C(=O)CC(SC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc3c[nH]cn3)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N3CCC[C@H]3C(=O)N3CCC[C@H]3C(=O)N3CCC[C@H]3C(=O)N[C@@H](CO)C(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)NCC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc3ccccc3)C(N)=O)CSC3CC(=O)N(CCC(=O)N1)C3=O)C2=O 10.1021/acs.jmedchem.0c00736
90663239 113401 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Tested for the 50% inhibition level against [125I]- gastrin binding to guinea pig gastric glandsTested for the 50% inhibition level against [125I]- gastrin binding to guinea pig gastric glands
ChEMBL 946 27 8 11 2.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)CCC(=O)N(Cc1ccccc1)N=NCCCl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00048a016
CHEMBL3143011 113401 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Tested for the 50% inhibition level against [125I]- gastrin binding to guinea pig gastric glandsTested for the 50% inhibition level against [125I]- gastrin binding to guinea pig gastric glands
ChEMBL 946 27 8 11 2.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)CCC(=O)N(Cc1ccccc1)N=NCCCl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00048a016
162677145 190248 0 None - 0 Human 8.0 pEC50 = 8.0 Binding
Agonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 minsAgonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 mins
ChEMBL 5323 168 69 75 -17.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CS)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)[C@@H](C)CC 10.1021/acs.jmedchem.0c00736
CHEMBL4799182 190248 0 None - 0 Human 8.0 pEC50 = 8.0 Binding
Agonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 minsAgonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 mins
ChEMBL 5323 168 69 75 -17.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CS)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)[C@@H](C)CC 10.1021/acs.jmedchem.0c00736
86291008 186331 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 minsAgonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 mins
ChEMBL 4364 151 59 60 -13.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.0c00736
CHEMBL4741697 186331 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 minsAgonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 mins
ChEMBL 4364 151 59 60 -13.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.0c00736
44348922 23013 0 None - 0 Bovine 10.5 pIC50 = 10.5 Binding
Inhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatumInhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatum
ChEMBL 992 25 11 11 1.4 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC1CCC[C@H]1NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00099a005
CHEMBL122438 23013 0 None - 0 Bovine 10.5 pIC50 = 10.5 Binding
Inhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatumInhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatum
ChEMBL 992 25 11 11 1.4 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC1CCC[C@H]1NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00099a005
880 9019 5 None - 0 Human 10.3 pIC50 = 10.3 Binding
Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesInhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranes
ChEMBL 487 5 3 7 3.5 O=C(N[C@@H]1N=C(C2CCCCC2)c2c(N(C1=O)C)cccc2)Nc1cccc(c1)N(c1n[nH]nn1)C 10.1021/jm9506736
9935175 9019 5 None - 0 Human 10.3 pIC50 = 10.3 Binding
Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesInhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranes
ChEMBL 487 5 3 7 3.5 O=C(N[C@@H]1N=C(C2CCCCC2)c2c(N(C1=O)C)cccc2)Nc1cccc(c1)N(c1n[nH]nn1)C 10.1021/jm9506736
CHEMBL2093059 9019 5 None - 0 Human 10.3 pIC50 = 10.3 Binding
Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesInhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranes
ChEMBL 487 5 3 7 3.5 O=C(N[C@@H]1N=C(C2CCCCC2)c2c(N(C1=O)C)cccc2)Nc1cccc(c1)N(c1n[nH]nn1)C 10.1021/jm9506736
10051431 127904 0 None - 0 Rat 10.2 pIC50 = 10.2 Binding
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 494 6 2 4 5.1 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1016/0960-894X(95)00556-9
CHEMBL357502 127904 0 None - 0 Rat 10.2 pIC50 = 10.2 Binding
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 494 6 2 4 5.1 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1016/0960-894X(95)00556-9
10480605 85135 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesInhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranes
ChEMBL 487 5 4 7 3.7 Cc1ccc(NC(=O)N[C@@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)cc1Nc1nn[nH]n1 10.1021/jm9506736
CHEMBL2110201 85135 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesInhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranes
ChEMBL 487 5 4 7 3.7 Cc1ccc(NC(=O)N[C@@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)cc1Nc1nn[nH]n1 10.1021/jm9506736
9916170 83328 3 None - 0 Mouse 10.1 pIC50 = 10.1 Binding
Binding affinity towards Cholecystokinin type B receptor in mouse cortex membraneBinding affinity towards Cholecystokinin type B receptor in mouse cortex membrane
ChEMBL 575 10 4 4 5.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CC(=O)O)Cc1ccc(F)cc1 10.1016/s0960-894x(00)00198-0
CHEMBL2062146 83328 3 None - 0 Mouse 10.1 pIC50 = 10.1 Binding
Binding affinity towards Cholecystokinin type B receptor in mouse cortex membraneBinding affinity towards Cholecystokinin type B receptor in mouse cortex membrane
ChEMBL 575 10 4 4 5.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CC(=O)O)Cc1ccc(F)cc1 10.1016/s0960-894x(00)00198-0
44348850 24720 0 None - 0 Bovine 10.1 pIC50 = 10.1 Binding
Inhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatumInhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatum
ChEMBL 986 24 11 11 2.0 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccc(NC(=O)[C@H](Cc2ccc(S(=O)(=O)O)cc2)NC(=O)O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00099a005
CHEMBL126008 24720 0 None - 0 Bovine 10.1 pIC50 = 10.1 Binding
Inhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatumInhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatum
ChEMBL 986 24 11 11 2.0 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccc(NC(=O)[C@H](Cc2ccc(S(=O)(=O)O)cc2)NC(=O)O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00099a005
9960703 174817 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Compound was evaluated for the inhibition of 124 I-CCK-8 binding at Cholecystokinin type B receptor on guinea pig cerebral cortical membranesCompound was evaluated for the inhibition of 124 I-CCK-8 binding at Cholecystokinin type B receptor on guinea pig cerebral cortical membranes
ChEMBL 621 6 3 7 4.0 O=C(Nc1cccc(-c2nn[nH]n2)c1)NC1N=C(c2ccccc2F)c2ccccc2N(CC(=O)N2CC3CCC(CC3)C2)C1=O 10.1016/s0960-894x(98)00237-6
CHEMBL432266 174817 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Compound was evaluated for the inhibition of 124 I-CCK-8 binding at Cholecystokinin type B receptor on guinea pig cerebral cortical membranesCompound was evaluated for the inhibition of 124 I-CCK-8 binding at Cholecystokinin type B receptor on guinea pig cerebral cortical membranes
ChEMBL 621 6 3 7 4.0 O=C(Nc1cccc(-c2nn[nH]n2)c1)NC1N=C(c2ccccc2F)c2ccccc2N(CC(=O)N2CC3CCC(CC3)C2)C1=O 10.1016/s0960-894x(98)00237-6
9872735 193806 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Inhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesInhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranes
ChEMBL 567 5 2 4 5.1 Cc1cccc(NC(=O)NC2N=C(c3ccccc3F)c3ccccc3N(CC(=O)N3CC4CCC(CC4)C3)C2=O)c1 10.1016/S0960-894X(96)00609-9
CHEMBL49085 193806 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Inhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesInhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranes
ChEMBL 567 5 2 4 5.1 Cc1cccc(NC(=O)NC2N=C(c3ccccc3F)c3ccccc3N(CC(=O)N3CC4CCC(CC4)C3)C2=O)c1 10.1016/S0960-894X(96)00609-9
155559320 181643 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1872 72 18 23 3.8 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4563364 181643 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1872 72 18 23 3.8 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O 10.1021/acs.jmedchem.8b01558
21842340 50864 0 None - 0 Rat 10.0 pIC50 = 10 Binding
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 508 6 2 4 5.5 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3(C)CCCC3)C2=O)c1 10.1016/0960-894X(95)00556-9
CHEMBL151483 50864 0 None - 0 Rat 10.0 pIC50 = 10 Binding
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 508 6 2 4 5.5 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3(C)CCCC3)C2=O)c1 10.1016/0960-894X(95)00556-9
132980 9020 12 None - 1 Human 10.0 pIC50 = 10 Binding
Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.
ChEMBL 445 2 2 4 4.0 Cc1cccc(c1)NC(=O)N[C@@H]1N=C(N2CC3CCC(C2)CC3)c2c(N(C1=O)C)cccc2 10.1021/jm00032a002
881 9020 12 None - 1 Human 10.0 pIC50 = 10 Binding
Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.
ChEMBL 445 2 2 4 4.0 Cc1cccc(c1)NC(=O)N[C@@H]1N=C(N2CC3CCC(C2)CC3)c2c(N(C1=O)C)cccc2 10.1021/jm00032a002
CHEMBL420783 9020 12 None - 1 Human 10.0 pIC50 = 10 Binding
Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.
ChEMBL 445 2 2 4 4.0 Cc1cccc(c1)NC(=O)N[C@@H]1N=C(N2CC3CCC(C2)CC3)c2c(N(C1=O)C)cccc2 10.1021/jm00032a002
9828961 174765 0 None - 0 Human 10.0 pIC50 = 10 Binding
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 548 6 4 4 5.2 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)O)c1)C[C@@H]2C1CCCCC1 10.1016/0960-894X(95)00327-P
CHEMBL431919 174765 0 None - 0 Human 10.0 pIC50 = 10 Binding
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 548 6 4 4 5.2 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)O)c1)C[C@@H]2C1CCCCC1 10.1016/0960-894X(95)00327-P
132980 9020 12 None - 1 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortexDisplacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortex
ChEMBL 445 2 2 4 4.0 Cc1cccc(c1)NC(=O)N[C@@H]1N=C(N2CC3CCC(C2)CC3)c2c(N(C1=O)C)cccc2 10.1016/0960-894X(95)00530-0
881 9020 12 None - 1 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortexDisplacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortex
ChEMBL 445 2 2 4 4.0 Cc1cccc(c1)NC(=O)N[C@@H]1N=C(N2CC3CCC(C2)CC3)c2c(N(C1=O)C)cccc2 10.1016/0960-894X(95)00530-0
CHEMBL420783 9020 12 None - 1 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortexDisplacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortex
ChEMBL 445 2 2 4 4.0 Cc1cccc(c1)NC(=O)N[C@@H]1N=C(N2CC3CCC(C2)CC3)c2c(N(C1=O)C)cccc2 10.1016/0960-894X(95)00530-0
21842392 173487 21 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]-gastrin17 from CCK-B receptor (unknown origin)Displacement of [125I]-gastrin17 from CCK-B receptor (unknown origin)
ChEMBL 498 6 3 6 4.1 CNc1cccc(NC(=O)NC2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1039/C7MD00171A
CHEMBL4282712 173487 21 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]-gastrin17 from CCK-B receptor (unknown origin)Displacement of [125I]-gastrin17 from CCK-B receptor (unknown origin)
ChEMBL 498 6 3 6 4.1 CNc1cccc(NC(=O)NC2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1039/C7MD00171A
132980 9020 12 None - 1 Human 10.0 pIC50 = 10 Binding
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 445 2 2 4 4.0 Cc1cccc(c1)NC(=O)N[C@@H]1N=C(N2CC3CCC(C2)CC3)c2c(N(C1=O)C)cccc2 10.1021/jm9608523
881 9020 12 None - 1 Human 10.0 pIC50 = 10 Binding
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 445 2 2 4 4.0 Cc1cccc(c1)NC(=O)N[C@@H]1N=C(N2CC3CCC(C2)CC3)c2c(N(C1=O)C)cccc2 10.1021/jm9608523
CHEMBL420783 9020 12 None - 1 Human 10.0 pIC50 = 10 Binding
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 445 2 2 4 4.0 Cc1cccc(c1)NC(=O)N[C@@H]1N=C(N2CC3CCC(C2)CC3)c2c(N(C1=O)C)cccc2 10.1021/jm9608523
887 10882 33 None 1 4 Rat 10.0 pIC50 = 10 Binding
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 10.1021/jm960669+
9870520 10882 33 None 1 4 Rat 10.0 pIC50 = 10 Binding
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 10.1021/jm960669+
CHEMBL324547 10882 33 None 1 4 Rat 10.0 pIC50 = 10 Binding
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 10.1021/jm960669+
DB12355 10882 33 None 1 4 Rat 10.0 pIC50 = 10 Binding
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 10.1021/jm960669+
122130 10887 39 None - 1 Rat 10.0 pIC50 = 10.0 Binding
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 516 6 2 4 5.5 Cc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccc2)c2c(N(C1=O)CC(=O)c1ccccc1C)cccc2 10.1016/0960-894X(95)00556-9
888 10887 39 None - 1 Rat 10.0 pIC50 = 10.0 Binding
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 516 6 2 4 5.5 Cc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccc2)c2c(N(C1=O)CC(=O)c1ccccc1C)cccc2 10.1016/0960-894X(95)00556-9
CHEMBL115121 10887 39 None - 1 Rat 10.0 pIC50 = 10.0 Binding
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 516 6 2 4 5.5 Cc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccc2)c2c(N(C1=O)CC(=O)c1ccccc1C)cccc2 10.1016/0960-894X(95)00556-9
3452843 126303 15 None - 10 Rat 10.0 pIC50 = 10.0 Binding
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligandBinding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligand
ChEMBL 516 6 2 4 5.5 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1 10.1016/0960-894X(95)00557-A
CHEMBL345686 126303 15 None - 10 Rat 10.0 pIC50 = 10.0 Binding
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligandBinding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligand
ChEMBL 516 6 2 4 5.5 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1 10.1016/0960-894X(95)00557-A
10323431 64526 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesInhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranes
ChEMBL 493 4 3 7 2.9 CN1C(=O)[C@H](NC(=O)Nc2ccc3c(c2)N(c2nn[nH]n2)CC3)N=C(c2ccccc2)c2ccccc21 10.1021/jm9506736
CHEMBL166941 64526 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesInhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranes
ChEMBL 493 4 3 7 2.9 CN1C(=O)[C@H](NC(=O)Nc2ccc3c(c2)N(c2nn[nH]n2)CC3)N=C(c2ccccc2)c2ccccc21 10.1021/jm9506736
122130 10887 39 None - 1 Rat 10.0 pIC50 = 10.0 Binding
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 516 6 2 4 5.5 Cc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccc2)c2c(N(C1=O)CC(=O)c1ccccc1C)cccc2 10.1021/jm960669+
888 10887 39 None - 1 Rat 10.0 pIC50 = 10.0 Binding
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 516 6 2 4 5.5 Cc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccc2)c2c(N(C1=O)CC(=O)c1ccccc1C)cccc2 10.1021/jm960669+
CHEMBL115121 10887 39 None - 1 Rat 10.0 pIC50 = 10.0 Binding
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 516 6 2 4 5.5 Cc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccc2)c2c(N(C1=O)CC(=O)c1ccccc1C)cccc2 10.1021/jm960669+
24039375 16659 0 None - 0 Rat 10.0 pIC50 = 10.0 Binding
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 540 8 2 6 4.9 CCN(CC)c1cccc(NC(=O)N[C@@H]2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm960669+
CHEMBL114277 16659 0 None - 0 Rat 10.0 pIC50 = 10.0 Binding
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 540 8 2 6 4.9 CCN(CC)c1cccc(NC(=O)N[C@@H]2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm960669+
9850184 117648 0 None - 0 Rat 10.0 pIC50 = 10.0 Binding
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 538 6 2 6 4.6 CC(C)(C)C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(N3CCCC3)c2)N=C(c2ccccn2)c2ccccc21 10.1021/jm960669+
CHEMBL326102 117648 0 None - 0 Rat 10.0 pIC50 = 10.0 Binding
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 538 6 2 6 4.6 CC(C)(C)C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(N3CCCC3)c2)N=C(c2ccccn2)c2ccccc21 10.1021/jm960669+
23844129 120276 0 None - 0 Rat 10.0 pIC50 = 10.0 Binding
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 497 6 3 5 4.7 CNc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm960669+
CHEMBL332024 120276 0 None - 0 Rat 10.0 pIC50 = 10.0 Binding
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 497 6 3 5 4.7 CNc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm960669+
21842325 126900 0 None - 0 Rat 9.9 pIC50 = 9.9 Binding
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligandBinding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligand
ChEMBL 495 6 2 5 4.5 Cc1cccc(NC(=O)NC2N=C(c3ccccn3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1016/0960-894X(95)00557-A
CHEMBL351144 126900 0 None - 0 Rat 9.9 pIC50 = 9.9 Binding
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligandBinding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligand
ChEMBL 495 6 2 5 4.5 Cc1cccc(NC(=O)NC2N=C(c3ccccn3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1016/0960-894X(95)00557-A
4627 7609 50 None -1 5 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]CCK-8s from human recombinant CCK-B receptor expressed in CHO cellsDisplacement of [125I]CCK-8s from human recombinant CCK-B receptor expressed in CHO cells
ChEMBL None None None None 10.1016/j.bmc.2016.03.006
864 7609 50 None -1 5 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]CCK-8s from human recombinant CCK-B receptor expressed in CHO cellsDisplacement of [125I]CCK-8s from human recombinant CCK-B receptor expressed in CHO cells
ChEMBL None None None None 10.1016/j.bmc.2016.03.006
9833444 7609 50 None -1 5 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]CCK-8s from human recombinant CCK-B receptor expressed in CHO cellsDisplacement of [125I]CCK-8s from human recombinant CCK-B receptor expressed in CHO cells
ChEMBL None None None None 10.1016/j.bmc.2016.03.006
CHEMBL1121 7609 50 None -1 5 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]CCK-8s from human recombinant CCK-B receptor expressed in CHO cellsDisplacement of [125I]CCK-8s from human recombinant CCK-B receptor expressed in CHO cells
ChEMBL None None None None 10.1016/j.bmc.2016.03.006
DB09142 7609 50 None -1 5 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]CCK-8s from human recombinant CCK-B receptor expressed in CHO cellsDisplacement of [125I]CCK-8s from human recombinant CCK-B receptor expressed in CHO cells
ChEMBL None None None None 10.1016/j.bmc.2016.03.006
4627 7609 50 None -1 5 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]CCK-8s from human recombinant CCK2 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [125I]CCK-8s from human recombinant CCK2 receptor expressed in CHO cells measured after 60 mins by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
864 7609 50 None -1 5 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]CCK-8s from human recombinant CCK2 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [125I]CCK-8s from human recombinant CCK2 receptor expressed in CHO cells measured after 60 mins by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
9833444 7609 50 None -1 5 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]CCK-8s from human recombinant CCK2 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [125I]CCK-8s from human recombinant CCK2 receptor expressed in CHO cells measured after 60 mins by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
CHEMBL1121 7609 50 None -1 5 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]CCK-8s from human recombinant CCK2 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [125I]CCK-8s from human recombinant CCK2 receptor expressed in CHO cells measured after 60 mins by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
DB09142 7609 50 None -1 5 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]CCK-8s from human recombinant CCK2 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [125I]CCK-8s from human recombinant CCK2 receptor expressed in CHO cells measured after 60 mins by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
10006792 51699 0 None - 0 Rat 9.9 pIC50 = 9.9 Binding
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligandBinding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligand
ChEMBL 517 6 2 5 4.9 Cc1cccc(NC(=O)NC2N=C(c3ccccn3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1 10.1016/0960-894X(95)00557-A
CHEMBL152306 51699 0 None - 0 Rat 9.9 pIC50 = 9.9 Binding
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligandBinding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligand
ChEMBL 517 6 2 5 4.9 Cc1cccc(NC(=O)NC2N=C(c3ccccn3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1 10.1016/0960-894X(95)00557-A
155543846 179991 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1838 72 19 24 2.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4522865 179991 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1838 72 19 24 2.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/acs.jmedchem.8b01558
155546692 180421 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1861 72 19 23 3.2 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4534236 180421 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1861 72 19 23 3.2 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O 10.1021/acs.jmedchem.8b01558
108187 7713 37 None -4 5 Human 9.9 pIC50 = 9.9 Binding
In vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cellsIn vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm00017a022
873 7713 37 None -4 5 Human 9.9 pIC50 = 9.9 Binding
In vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cellsIn vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm00017a022
CHEMBL2062154 7713 37 None -4 5 Human 9.9 pIC50 = 9.9 Binding
In vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cellsIn vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm00017a022
CHEMBL287735 7713 37 None -4 5 Human 9.9 pIC50 = 9.9 Binding
In vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cellsIn vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm00017a022
23757281 16623 0 None - 0 Rat 9.9 pIC50 = 9.9 Binding
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 539 8 2 5 5.5 CCN(CC)c1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm960669+
CHEMBL114072 16623 0 None - 0 Rat 9.9 pIC50 = 9.9 Binding
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 539 8 2 5 5.5 CCN(CC)c1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm960669+
44376113 126739 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
The compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligandThe compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligand
ChEMBL 494 6 3 6 3.9 CC(C)CN1C(=O)[C@@H](NC(=O)Nc2ccc(-c3nn[nH]n3)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00032a003
CHEMBL349730 126739 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
The compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligandThe compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligand
ChEMBL 494 6 3 6 3.9 CC(C)CN1C(=O)[C@@H](NC(=O)Nc2ccc(-c3nn[nH]n3)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00032a003
903 9798 9 None - 1 Mouse 9.8 pIC50 = 9.8 Binding
Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1016/S0960-894X(00)80273-5
9850711 9798 9 None - 1 Mouse 9.8 pIC50 = 9.8 Binding
Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1016/S0960-894X(00)80273-5
CHEMBL138534 9798 9 None - 1 Mouse 9.8 pIC50 = 9.8 Binding
Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1016/S0960-894X(00)80273-5
CHEMBL2111312 9798 9 None - 1 Mouse 9.8 pIC50 = 9.8 Binding
Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1016/S0960-894X(00)80273-5
903 9798 9 None - 1 Mouse 9.8 pIC50 = 9.8 Binding
Half maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortexHalf maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1021/jm000937a
9850711 9798 9 None - 1 Mouse 9.8 pIC50 = 9.8 Binding
Half maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortexHalf maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1021/jm000937a
CHEMBL138534 9798 9 None - 1 Mouse 9.8 pIC50 = 9.8 Binding
Half maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortexHalf maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1021/jm000937a
CHEMBL2111312 9798 9 None - 1 Mouse 9.8 pIC50 = 9.8 Binding
Half maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortexHalf maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1021/jm000937a
904 9800 10 None - 1 Mouse 9.8 pIC50 = 9.8 Binding
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1016/S0960-894X(01)80769-1
9915756 9800 10 None - 1 Mouse 9.8 pIC50 = 9.8 Binding
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1016/S0960-894X(01)80769-1
CHEMBL2111204 9800 10 None - 1 Mouse 9.8 pIC50 = 9.8 Binding
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1016/S0960-894X(01)80769-1
CHEMBL356898 9800 10 None - 1 Mouse 9.8 pIC50 = 9.8 Binding
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1016/S0960-894X(01)80769-1
903 9798 9 None - 1 Mouse 9.8 pIC50 = 9.8 Binding
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1016/S0960-894X(00)80685-X
9850711 9798 9 None - 1 Mouse 9.8 pIC50 = 9.8 Binding
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1016/S0960-894X(00)80685-X
CHEMBL138534 9798 9 None - 1 Mouse 9.8 pIC50 = 9.8 Binding
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1016/S0960-894X(00)80685-X
CHEMBL2111312 9798 9 None - 1 Mouse 9.8 pIC50 = 9.8 Binding
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1016/S0960-894X(00)80685-X
903 9798 9 None - 1 Mouse 9.8 pIC50 = 9.8 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1021/jm970065l
9850711 9798 9 None - 1 Mouse 9.8 pIC50 = 9.8 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1021/jm970065l
CHEMBL138534 9798 9 None - 1 Mouse 9.8 pIC50 = 9.8 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1021/jm970065l
CHEMBL2111312 9798 9 None - 1 Mouse 9.8 pIC50 = 9.8 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1021/jm970065l
155558199 181548 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1894 75 19 24 2.9 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4561184 181548 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1894 75 19 24 2.9 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
155533399 178624 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1838 72 19 24 1.4 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4468861 178624 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1838 72 19 24 1.4 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
10744359 16929 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 513 6 2 6 4.5 CC(C)(C)C(=O)CN1C(=O)C(NC(=O)Nc2cccc([N+](=O)[O-])c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm960669+
CHEMBL115833 16929 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 513 6 2 6 4.5 CC(C)(C)C(=O)CN1C(=O)C(NC(=O)Nc2cccc([N+](=O)[O-])c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm960669+
155544674 181715 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1822 71 18 23 2.5 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4565336 181715 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1822 71 18 23 2.5 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
15291593 119629 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 537 6 2 5 5.2 CC(C)(C)C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(N3CCCC3)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm960669+
CHEMBL330933 119629 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 537 6 2 5 5.2 CC(C)(C)C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(N3CCCC3)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm960669+
9828961 174765 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 548 6 4 4 5.2 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)O)c1)C[C@@H]2C1CCCCC1 10.1016/0960-894X(95)00327-P
CHEMBL431919 174765 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 548 6 4 4 5.2 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)O)c1)C[C@@H]2C1CCCCC1 10.1016/0960-894X(95)00327-P
11798691 65045 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesInhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranes
ChEMBL 473 5 4 7 3.4 CN1C(=O)[C@H](NC(=O)Nc2cccc(Nc3nn[nH]n3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm9506736
CHEMBL168263 65045 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesInhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranes
ChEMBL 473 5 4 7 3.4 CN1C(=O)[C@H](NC(=O)Nc2cccc(Nc3nn[nH]n3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm9506736
CHEMBL384035 219095 4 None 8 4 Human 9.7 pIC50 = 9.7 Binding
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat TcellsInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat Tcells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00072a024
CHEMBL428666 219095 4 None 8 4 Human 9.7 pIC50 = 9.7 Binding
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat TcellsInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat Tcells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00072a024
10839478 117434 1 None - 0 Rat 9.7 pIC50 = 9.7 Binding
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 512 6 2 6 4.1 CN(C)c1cccc(NC(=O)N[C@@H]2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm960669+
CHEMBL325863 117434 1 None - 0 Rat 9.7 pIC50 = 9.7 Binding
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 512 6 2 6 4.1 CN(C)c1cccc(NC(=O)N[C@@H]2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm960669+
145993882 174115 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
Displacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting methodDisplacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting method
ChEMBL 509 5 4 6 4.2 O=C(O)c1cccc(NC(=S)NNc2nc3ccccc3c(=O)n2-c2ccc(Br)cc2)c1 10.1039/C7MD00171A
CHEMBL4294388 174115 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
Displacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting methodDisplacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting method
ChEMBL 509 5 4 6 4.2 O=C(O)c1cccc(NC(=S)NNc2nc3ccccc3c(=O)n2-c2ccc(Br)cc2)c1 10.1039/C7MD00171A
155516677 176868 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1822 72 18 23 2.7 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4443415 176868 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1822 72 18 23 2.7 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
44368611 128772 0 None - 0 Mouse 9.7 pIC50 = 9.7 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 541 10 4 3 4.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)C1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CC(=O)O)Cc1ccccc1 10.1021/jm00057a005
CHEMBL359292 128772 0 None - 0 Mouse 9.7 pIC50 = 9.7 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 541 10 4 3 4.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)C1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CC(=O)O)Cc1ccccc1 10.1021/jm00057a005
23928173 120925 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 511 6 2 5 4.7 CN(C)c1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm960669+
CHEMBL332931 120925 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 511 6 2 5 4.7 CN(C)c1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm960669+
CHEMBL382409 219085 0 None 6918 2 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
44300743 107737 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 572 6 4 6 4.7 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(-c3nn[nH]n3)c1)C[C@@H]2C1CCCCC1 10.1016/0960-894X(95)00327-P
CHEMBL294161 107737 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 572 6 4 6 4.7 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(-c3nn[nH]n3)c1)C[C@@H]2C1CCCCC1 10.1016/0960-894X(95)00327-P
10459108 35182 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 513 8 2 5 3.9 CCN(CC)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(OC)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL137516 35182 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 513 8 2 5 3.9 CCN(CC)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(OC)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
4627 7609 50 None -1 5 Human 9.6 pIC50 = 9.6 Binding
Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8
ChEMBL None None None None 10.1021/jm960249k
864 7609 50 None -1 5 Human 9.6 pIC50 = 9.6 Binding
Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8
ChEMBL None None None None 10.1021/jm960249k
9833444 7609 50 None -1 5 Human 9.6 pIC50 = 9.6 Binding
Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8
ChEMBL None None None None 10.1021/jm960249k
CHEMBL1121 7609 50 None -1 5 Human 9.6 pIC50 = 9.6 Binding
Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8
ChEMBL None None None None 10.1021/jm960249k
DB09142 7609 50 None -1 5 Human 9.6 pIC50 = 9.6 Binding
Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8
ChEMBL None None None None 10.1021/jm960249k
21842375 51044 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 494 6 2 4 5.1 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1016/0960-894X(95)00556-9
CHEMBL151719 51044 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 494 6 2 4 5.1 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1016/0960-894X(95)00556-9
21842375 51044 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligandBinding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligand
ChEMBL 494 6 2 4 5.1 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1016/0960-894X(95)00557-A
CHEMBL151719 51044 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligandBinding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligand
ChEMBL 494 6 2 4 5.1 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1016/0960-894X(95)00557-A
44313549 211621 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Binding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranesBinding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranes
ChEMBL 573 6 3 6 4.3 CN1C(=O)C(NC(=O)Nc2cccc(S(=O)(=O)NC(=O)c3ccccc3)c2)N=C(C2CCCCC2)c2ccccc21 10.1016/0960-894X(95)00399-E
CHEMBL75490 211621 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Binding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranesBinding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranes
ChEMBL 573 6 3 6 4.3 CN1C(=O)C(NC(=O)Nc2cccc(S(=O)(=O)NC(=O)c3ccccc3)c2)N=C(C2CCCCC2)c2ccccc21 10.1016/0960-894X(95)00399-E
10440992 168075 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 990 28 9 11 1.8 CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
CHEMBL412238 168075 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 990 28 9 11 1.8 CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
10075097 35417 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 511 6 2 5 3.6 COc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 10.1021/jm00078a018
CHEMBL137726 35417 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 511 6 2 5 3.6 COc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 10.1021/jm00078a018
44331825 174752 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL 692 5 1 6 5.1 CC(C)(C)OC(=O)N1c2ccccc2C[C@@H]1C(=O)N1[C@H](c2ccccc2)CC[C@@H]1C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1CCCC1C(=O)O 10.1016/S0960-894X(96)00546-X
CHEMBL431805 174752 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL 692 5 1 6 5.1 CC(C)(C)OC(=O)N1c2ccccc2C[C@@H]1C(=O)N1[C@H](c2ccccc2)CC[C@@H]1C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1CCCC1C(=O)O 10.1016/S0960-894X(96)00546-X
44300989 107757 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 625 7 4 6 4.2 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)NS(C)(=O)=O)c1)C[C@@H]2C1CCCCC1 10.1016/0960-894X(95)00327-P
CHEMBL294252 107757 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 625 7 4 6 4.2 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)NS(C)(=O)=O)c1)C[C@@H]2C1CCCCC1 10.1016/0960-894X(95)00327-P
136055865 126974 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
The compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligandThe compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligand
ChEMBL 468 4 3 7 3.4 CN1C(=O)[C@@H](NC(=O)Nc2ccc(-c3noc(O)n3)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00032a003
CHEMBL351891 126974 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
The compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligandThe compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligand
ChEMBL 468 4 3 7 3.4 CN1C(=O)[C@@H](NC(=O)Nc2ccc(-c3noc(O)n3)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00032a003
10257790 109632 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Binding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranesBinding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranes
ChEMBL 587 6 3 6 4.6 Cc1ccccc1S(=O)(=O)NC(=O)c1cccc(NC(=O)N[C@@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 10.1016/0960-894X(95)00399-E
CHEMBL305649 109632 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Binding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranesBinding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranes
ChEMBL 587 6 3 6 4.6 Cc1ccccc1S(=O)(=O)NC(=O)c1cccc(NC(=O)N[C@@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 10.1016/0960-894X(95)00399-E
21842331 50312 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 522 7 2 4 5.9 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)CC3CCCCC3)C2=O)c1 10.1016/0960-894X(95)00556-9
CHEMBL150869 50312 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 522 7 2 4 5.9 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)CC3CCCCC3)C2=O)c1 10.1016/0960-894X(95)00556-9
10414170 177397 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 515 5 2 4 4.3 O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N2CCCC2)C1=O 10.1016/S0960-894X(00)80683-6
CHEMBL445095 177397 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 515 5 2 4 4.3 O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N2CCCC2)C1=O 10.1016/S0960-894X(00)80683-6
9953071 205844 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.
ChEMBL 404 3 2 3 4.5 Cc1cccc(NC(=O)N[C@@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 10.1021/jm00032a002
CHEMBL58699 205844 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.
ChEMBL 404 3 2 3 4.5 Cc1cccc(NC(=O)N[C@@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 10.1021/jm00032a002
9953071 205844 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Binding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranesBinding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranes
ChEMBL 404 3 2 3 4.5 Cc1cccc(NC(=O)N[C@@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 10.1016/0960-894X(95)00399-E
CHEMBL58699 205844 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Binding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranesBinding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranes
ChEMBL 404 3 2 3 4.5 Cc1cccc(NC(=O)N[C@@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 10.1016/0960-894X(95)00399-E
10414170 177397 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 515 5 2 4 4.3 O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N2CCCC2)C1=O 10.1021/jm00121a004
CHEMBL445095 177397 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 515 5 2 4 4.3 O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N2CCCC2)C1=O 10.1021/jm00121a004
9953071 205844 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
In vitro test for inhibition of [125I]CCK binding to Cholecystokinin type B receptor from guinea pig cortical membranes was determinedIn vitro test for inhibition of [125I]CCK binding to Cholecystokinin type B receptor from guinea pig cortical membranes was determined
ChEMBL 404 3 2 3 4.5 Cc1cccc(NC(=O)N[C@@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(01)80987-2
CHEMBL58699 205844 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
In vitro test for inhibition of [125I]CCK binding to Cholecystokinin type B receptor from guinea pig cortical membranes was determinedIn vitro test for inhibition of [125I]CCK binding to Cholecystokinin type B receptor from guinea pig cortical membranes was determined
ChEMBL 404 3 2 3 4.5 Cc1cccc(NC(=O)N[C@@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(01)80987-2
10719765 85136 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesInhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranes
ChEMBL 487 6 4 7 3.3 CN1C(=O)[C@H](NC(=O)Nc2cccc(CNc3nn[nH]n3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm9506736
CHEMBL2110202 85136 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesInhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranes
ChEMBL 487 6 4 7 3.3 CN1C(=O)[C@H](NC(=O)Nc2cccc(CNc3nn[nH]n3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm9506736
9953071 205844 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 404 3 2 3 4.5 Cc1cccc(NC(=O)N[C@@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 10.1021/jm9608523
CHEMBL58699 205844 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 404 3 2 3 4.5 Cc1cccc(NC(=O)N[C@@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 10.1021/jm9608523
4627 7609 50 None -1 5 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b01558
864 7609 50 None -1 5 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b01558
9833444 7609 50 None -1 5 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b01558
CHEMBL1121 7609 50 None -1 5 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b01558
DB09142 7609 50 None -1 5 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b01558
155555346 181151 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1836 71 17 23 2.9 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4551834 181151 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1836 71 17 23 2.9 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL384035 219095 4 None 8 4 Human 9.5 pIC50 = 9.5 Binding
In vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranesIn vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranes
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80679-4
CHEMBL428666 219095 4 None 8 4 Human 9.5 pIC50 = 9.5 Binding
In vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranesIn vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranes
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80679-4
CHEMBL384035 219095 4 None 8 4 Human 9.5 pIC50 = 9.5 Binding
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranesInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranes
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00072a024
CHEMBL428666 219095 4 None 8 4 Human 9.5 pIC50 = 9.5 Binding
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranesInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranes
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00072a024
4627 7609 50 None - 5 Mouse 9.5 pIC50 = 9.5 Binding
Binding affinity towards Cholecystokinin type B receptor in mouse cortex membraneBinding affinity towards Cholecystokinin type B receptor in mouse cortex membrane
ChEMBL None None None None 10.1016/s0960-894x(00)00198-0
864 7609 50 None - 5 Mouse 9.5 pIC50 = 9.5 Binding
Binding affinity towards Cholecystokinin type B receptor in mouse cortex membraneBinding affinity towards Cholecystokinin type B receptor in mouse cortex membrane
ChEMBL None None None None 10.1016/s0960-894x(00)00198-0
9833444 7609 50 None - 5 Mouse 9.5 pIC50 = 9.5 Binding
Binding affinity towards Cholecystokinin type B receptor in mouse cortex membraneBinding affinity towards Cholecystokinin type B receptor in mouse cortex membrane
ChEMBL None None None None 10.1016/s0960-894x(00)00198-0
CHEMBL1121 7609 50 None - 5 Mouse 9.5 pIC50 = 9.5 Binding
Binding affinity towards Cholecystokinin type B receptor in mouse cortex membraneBinding affinity towards Cholecystokinin type B receptor in mouse cortex membrane
ChEMBL None None None None 10.1016/s0960-894x(00)00198-0
DB09142 7609 50 None - 5 Mouse 9.5 pIC50 = 9.5 Binding
Binding affinity towards Cholecystokinin type B receptor in mouse cortex membraneBinding affinity towards Cholecystokinin type B receptor in mouse cortex membrane
ChEMBL None None None None 10.1016/s0960-894x(00)00198-0
18957789 211625 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Binding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranesBinding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranes
ChEMBL 539 6 3 6 3.6 CC(C)S(=O)(=O)NC(=O)c1cccc(NC(=O)NC2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 10.1016/0960-894X(95)00399-E
CHEMBL75536 211625 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Binding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranesBinding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranes
ChEMBL 539 6 3 6 3.6 CC(C)S(=O)(=O)NC(=O)c1cccc(NC(=O)NC2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 10.1016/0960-894X(95)00399-E
71460027 86490 0 None - 0 Mouse 9.5 pIC50 = 9.5 Binding
Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.
ChEMBL 541 9 4 4 5.3 O=C(O)C[C@H](Cc1ccccc1)NC(=O)C(=Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1016/S0960-894X(00)80273-5
CHEMBL2115544 86490 0 None - 0 Mouse 9.5 pIC50 = 9.5 Binding
Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.
ChEMBL 541 9 4 4 5.3 O=C(O)C[C@H](Cc1ccccc1)NC(=O)C(=Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1016/S0960-894X(00)80273-5
CHEMBL269098 217557 0 None - 0 Mouse 9.5 pIC50 = 9.5 Binding
Compound was tested for the inhibition of specific binding of [125I]bolton Hunter CCK-8 to Cholecystokinin type B receptor in mouse cerebral cortexCompound was tested for the inhibition of specific binding of [125I]bolton Hunter CCK-8 to Cholecystokinin type B receptor in mouse cerebral cortex
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCC(=O)N[C@@H](Cc1cc2ccccc2[nH]1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(01)81250-6
4627 7609 50 None - 5 Mouse 9.5 pIC50 = 9.5 Binding
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL None None None None 10.1021/jm00092a007
864 7609 50 None - 5 Mouse 9.5 pIC50 = 9.5 Binding
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL None None None None 10.1021/jm00092a007
9833444 7609 50 None - 5 Mouse 9.5 pIC50 = 9.5 Binding
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL None None None None 10.1021/jm00092a007
CHEMBL1121 7609 50 None - 5 Mouse 9.5 pIC50 = 9.5 Binding
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL None None None None 10.1021/jm00092a007
DB09142 7609 50 None - 5 Mouse 9.5 pIC50 = 9.5 Binding
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL None None None None 10.1021/jm00092a007
15667003 104114 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 1016 27 8 11 2.3 CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC(CCC)[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
CHEMBL269355 104114 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 1016 27 8 11 2.3 CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC(CCC)[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
4627 7609 50 None - 5 Mouse 9.5 pIC50 = 9.5 Binding
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL None None None None 10.1021/jm00105a062
864 7609 50 None - 5 Mouse 9.5 pIC50 = 9.5 Binding
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL None None None None 10.1021/jm00105a062
9833444 7609 50 None - 5 Mouse 9.5 pIC50 = 9.5 Binding
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL None None None None 10.1021/jm00105a062
CHEMBL1121 7609 50 None - 5 Mouse 9.5 pIC50 = 9.5 Binding
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL None None None None 10.1021/jm00105a062
DB09142 7609 50 None - 5 Mouse 9.5 pIC50 = 9.5 Binding
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL None None None None 10.1021/jm00105a062
10673039 65038 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesInhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranes
ChEMBL 501 5 3 7 3.8 Cc1ccc(NC(=O)N[C@@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)cc1N(C)c1nn[nH]n1 10.1021/jm9506736
CHEMBL168253 65038 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesInhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranes
ChEMBL 501 5 3 7 3.8 Cc1ccc(NC(=O)N[C@@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)cc1N(C)c1nn[nH]n1 10.1021/jm9506736
4627 7609 50 None - 5 Mouse 9.5 pIC50 = 9.5 Binding
Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL None None None None 10.1016/S0960-894X(00)80687-3
864 7609 50 None - 5 Mouse 9.5 pIC50 = 9.5 Binding
Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL None None None None 10.1016/S0960-894X(00)80687-3
9833444 7609 50 None - 5 Mouse 9.5 pIC50 = 9.5 Binding
Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL None None None None 10.1016/S0960-894X(00)80687-3
CHEMBL1121 7609 50 None - 5 Mouse 9.5 pIC50 = 9.5 Binding
Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL None None None None 10.1016/S0960-894X(00)80687-3
DB09142 7609 50 None - 5 Mouse 9.5 pIC50 = 9.5 Binding
Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL None None None None 10.1016/S0960-894X(00)80687-3
4627 7609 50 None - 5 Mouse 9.5 pIC50 = 9.5 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL None None None None 10.1021/jm00057a005
864 7609 50 None - 5 Mouse 9.5 pIC50 = 9.5 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL None None None None 10.1021/jm00057a005
9833444 7609 50 None - 5 Mouse 9.5 pIC50 = 9.5 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL None None None None 10.1021/jm00057a005
CHEMBL1121 7609 50 None - 5 Mouse 9.5 pIC50 = 9.5 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL None None None None 10.1021/jm00057a005
DB09142 7609 50 None - 5 Mouse 9.5 pIC50 = 9.5 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL None None None None 10.1021/jm00057a005
4627 7609 50 None -1 5 Human 9.5 pIC50 = 9.5 Binding
Compound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transfected with cDNA of human Cholecystokinin type B receptorCompound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transfected with cDNA of human Cholecystokinin type B receptor
ChEMBL None None None None 10.1021/jm9601664
864 7609 50 None -1 5 Human 9.5 pIC50 = 9.5 Binding
Compound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transfected with cDNA of human Cholecystokinin type B receptorCompound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transfected with cDNA of human Cholecystokinin type B receptor
ChEMBL None None None None 10.1021/jm9601664
9833444 7609 50 None -1 5 Human 9.5 pIC50 = 9.5 Binding
Compound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transfected with cDNA of human Cholecystokinin type B receptorCompound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transfected with cDNA of human Cholecystokinin type B receptor
ChEMBL None None None None 10.1021/jm9601664
CHEMBL1121 7609 50 None -1 5 Human 9.5 pIC50 = 9.5 Binding
Compound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transfected with cDNA of human Cholecystokinin type B receptorCompound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transfected with cDNA of human Cholecystokinin type B receptor
ChEMBL None None None None 10.1021/jm9601664
DB09142 7609 50 None -1 5 Human 9.5 pIC50 = 9.5 Binding
Compound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transfected with cDNA of human Cholecystokinin type B receptorCompound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transfected with cDNA of human Cholecystokinin type B receptor
ChEMBL None None None None 10.1021/jm9601664
4627 7609 50 None -1 5 Human 9.5 pIC50 = 9.5 Binding
Concentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor stably expressed in CHO-K1 cellsConcentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor stably expressed in CHO-K1 cells
ChEMBL None None None None 10.1021/jm950626d
864 7609 50 None -1 5 Human 9.5 pIC50 = 9.5 Binding
Concentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor stably expressed in CHO-K1 cellsConcentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor stably expressed in CHO-K1 cells
ChEMBL None None None None 10.1021/jm950626d
9833444 7609 50 None -1 5 Human 9.5 pIC50 = 9.5 Binding
Concentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor stably expressed in CHO-K1 cellsConcentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor stably expressed in CHO-K1 cells
ChEMBL None None None None 10.1021/jm950626d
CHEMBL1121 7609 50 None -1 5 Human 9.5 pIC50 = 9.5 Binding
Concentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor stably expressed in CHO-K1 cellsConcentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor stably expressed in CHO-K1 cells
ChEMBL None None None None 10.1021/jm950626d
DB09142 7609 50 None -1 5 Human 9.5 pIC50 = 9.5 Binding
Concentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor stably expressed in CHO-K1 cellsConcentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor stably expressed in CHO-K1 cells
ChEMBL None None None None 10.1021/jm950626d
4627 7609 50 None -1 5 Human 9.5 pIC50 = 9.5 Binding
Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes
ChEMBL None None None None 10.1021/jm00001a027
864 7609 50 None -1 5 Human 9.5 pIC50 = 9.5 Binding
Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes
ChEMBL None None None None 10.1021/jm00001a027
9833444 7609 50 None -1 5 Human 9.5 pIC50 = 9.5 Binding
Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes
ChEMBL None None None None 10.1021/jm00001a027
CHEMBL1121 7609 50 None -1 5 Human 9.5 pIC50 = 9.5 Binding
Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes
ChEMBL None None None None 10.1021/jm00001a027
DB09142 7609 50 None -1 5 Human 9.5 pIC50 = 9.5 Binding
Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes
ChEMBL None None None None 10.1021/jm00001a027
4627 7609 50 None -1 5 Human 9.5 pIC50 = 9.5 Binding
In vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cellsIn vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL None None None None 10.1021/jm00017a022
864 7609 50 None -1 5 Human 9.5 pIC50 = 9.5 Binding
In vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cellsIn vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL None None None None 10.1021/jm00017a022
9833444 7609 50 None -1 5 Human 9.5 pIC50 = 9.5 Binding
In vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cellsIn vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL None None None None 10.1021/jm00017a022
CHEMBL1121 7609 50 None -1 5 Human 9.5 pIC50 = 9.5 Binding
In vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cellsIn vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL None None None None 10.1021/jm00017a022
DB09142 7609 50 None -1 5 Human 9.5 pIC50 = 9.5 Binding
In vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cellsIn vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL None None None None 10.1021/jm00017a022
4627 7609 50 None -1 5 Human 9.5 pIC50 = 9.5 Binding
Tested for 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecystokinin type B receptorTested for 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecystokinin type B receptor
ChEMBL None None None None 10.1016/S0960-894X(97)00062-0
864 7609 50 None -1 5 Human 9.5 pIC50 = 9.5 Binding
Tested for 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecystokinin type B receptorTested for 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecystokinin type B receptor
ChEMBL None None None None 10.1016/S0960-894X(97)00062-0
9833444 7609 50 None -1 5 Human 9.5 pIC50 = 9.5 Binding
Tested for 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecystokinin type B receptorTested for 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecystokinin type B receptor
ChEMBL None None None None 10.1016/S0960-894X(97)00062-0
CHEMBL1121 7609 50 None -1 5 Human 9.5 pIC50 = 9.5 Binding
Tested for 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecystokinin type B receptorTested for 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecystokinin type B receptor
ChEMBL None None None None 10.1016/S0960-894X(97)00062-0
DB09142 7609 50 None -1 5 Human 9.5 pIC50 = 9.5 Binding
Tested for 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecystokinin type B receptorTested for 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecystokinin type B receptor
ChEMBL None None None None 10.1016/S0960-894X(97)00062-0
10074366 127376 0 None - 0 Mouse 9.5 pIC50 = 9.5 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 9 4 4 4.5 C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
CHEMBL3349028 127376 0 None - 0 Mouse 9.5 pIC50 = 9.5 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 9 4 4 4.5 C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
CHEMBL3545866 127376 0 None - 0 Mouse 9.5 pIC50 = 9.5 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 9 4 4 4.5 C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
4627 7609 50 None -1 5 Human 9.5 pIC50 = 9.5 Binding
Binding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligandBinding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligand
ChEMBL None None None None 10.1021/jm960205b
864 7609 50 None -1 5 Human 9.5 pIC50 = 9.5 Binding
Binding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligandBinding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligand
ChEMBL None None None None 10.1021/jm960205b
9833444 7609 50 None -1 5 Human 9.5 pIC50 = 9.5 Binding
Binding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligandBinding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligand
ChEMBL None None None None 10.1021/jm960205b
CHEMBL1121 7609 50 None -1 5 Human 9.5 pIC50 = 9.5 Binding
Binding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligandBinding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligand
ChEMBL None None None None 10.1021/jm960205b
DB09142 7609 50 None -1 5 Human 9.5 pIC50 = 9.5 Binding
Binding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligandBinding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligand
ChEMBL None None None None 10.1021/jm960205b
4627 7609 50 None -1 5 Human 9.5 pIC50 = 9.5 Binding
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL None None None None 10.1021/jm970265x
864 7609 50 None -1 5 Human 9.5 pIC50 = 9.5 Binding
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL None None None None 10.1021/jm970265x
9833444 7609 50 None -1 5 Human 9.5 pIC50 = 9.5 Binding
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL None None None None 10.1021/jm970265x
CHEMBL1121 7609 50 None -1 5 Human 9.5 pIC50 = 9.5 Binding
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL None None None None 10.1021/jm970265x
DB09142 7609 50 None -1 5 Human 9.5 pIC50 = 9.5 Binding
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL None None None None 10.1021/jm970265x
44210536 176140 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Binding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranesBinding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranes
ChEMBL 511 5 3 6 3.0 CC(=O)NS(=O)(=O)c1cccc(NC(=O)NC2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 10.1016/0960-894X(95)00399-E
CHEMBL441989 176140 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Binding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranesBinding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranes
ChEMBL 511 5 3 6 3.0 CC(=O)NS(=O)(=O)c1cccc(NC(=O)NC2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 10.1016/0960-894X(95)00399-E
44293892 168466 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Inhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesInhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranes
ChEMBL 613 6 2 5 5.8 CSc1cccc(NC(=O)NC2N=C(c3ccccc3F)c3cccc(C)c3N(CC(=O)N3CC4CCC(CC4)C3)C2=O)c1 10.1016/S0960-894X(96)00609-9
CHEMBL413267 168466 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Inhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesInhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranes
ChEMBL 613 6 2 5 5.8 CSc1cccc(NC(=O)NC2N=C(c3ccccc3F)c3cccc(C)c3N(CC(=O)N3CC4CCC(CC4)C3)C2=O)c1 10.1016/S0960-894X(96)00609-9
9892971 127775 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 522 6 2 4 5.9 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3(C)CCCCC3)C2=O)c1 10.1016/0960-894X(95)00556-9
CHEMBL356386 127775 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 522 6 2 4 5.9 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3(C)CCCCC3)C2=O)c1 10.1016/0960-894X(95)00556-9
10484212 106655 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Inhibition of [125I]-Cholecystokinin-8 (125I-CCK-8) binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesInhibition of [125I]-Cholecystokinin-8 (125I-CCK-8) binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranes
ChEMBL 635 6 3 7 4.3 Cc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(-c3nn[nH]n3)c1)N=C2c1ccccc1F 10.1016/S0960-894X(96)00609-9
CHEMBL285921 106655 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Inhibition of [125I]-Cholecystokinin-8 (125I-CCK-8) binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesInhibition of [125I]-Cholecystokinin-8 (125I-CCK-8) binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranes
ChEMBL 635 6 3 7 4.3 Cc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(-c3nn[nH]n3)c1)N=C2c1ccccc1F 10.1016/S0960-894X(96)00609-9
155564367 181935 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1836 72 18 23 2.9 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4570130 181935 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1836 72 18 23 2.9 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
21842313 175334 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 508 6 2 4 5.5 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3CCCCC3)C2=O)c1 10.1016/0960-894X(95)00556-9
CHEMBL435639 175334 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 508 6 2 4 5.5 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3CCCCC3)C2=O)c1 10.1016/0960-894X(95)00556-9
162659624 188015 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I][3-iodo Tyr12,Leu15]gastrin-I from human CCK2R expressed in human A431 cells measured after 1 hr by gamma counter analysisDisplacement of [125I][3-iodo Tyr12,Leu15]gastrin-I from human CCK2R expressed in human A431 cells measured after 1 hr by gamma counter analysis
ChEMBL 1449 38 15 19 -1.6 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 10.1021/acs.jmedchem.0c01233
CHEMBL4761587 188015 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I][3-iodo Tyr12,Leu15]gastrin-I from human CCK2R expressed in human A431 cells measured after 1 hr by gamma counter analysisDisplacement of [125I][3-iodo Tyr12,Leu15]gastrin-I from human CCK2R expressed in human A431 cells measured after 1 hr by gamma counter analysis
ChEMBL 1449 38 15 19 -1.6 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 10.1021/acs.jmedchem.0c01233
21842373 127758 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 480 6 2 4 4.7 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3(C)CC3)C2=O)c1 10.1016/0960-894X(95)00556-9
CHEMBL356226 127758 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 480 6 2 4 4.7 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3(C)CC3)C2=O)c1 10.1016/0960-894X(95)00556-9
23844130 16886 16 None - 0 Rat 9.4 pIC50 = 9.4 Binding
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 484 5 3 6 3.6 CC(C)(C)C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(N)c2)N=C(c2ccccn2)c2ccccc21 10.1021/jm960669+
CHEMBL115612 16886 16 None - 0 Rat 9.4 pIC50 = 9.4 Binding
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 484 5 3 6 3.6 CC(C)(C)C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(N)c2)N=C(c2ccccn2)c2ccccc21 10.1021/jm960669+
9982757 58245 1 None - 0 Rat 9.4 pIC50 = 9.4 Binding
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligandBinding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligand
ChEMBL 483 5 2 5 4.3 Cc1cccc(NC(=O)NC2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1016/0960-894X(95)00557-A
CHEMBL158235 58245 1 None - 0 Rat 9.4 pIC50 = 9.4 Binding
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligandBinding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligand
ChEMBL 483 5 2 5 4.3 Cc1cccc(NC(=O)NC2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1016/0960-894X(95)00557-A
9891461 171801 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 483 5 2 5 4.3 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm960669+
CHEMBL422604 171801 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 483 5 2 5 4.3 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm960669+
CHEMBL37830 219039 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Binding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cellsBinding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cells
ChEMBL None None None CCCS[C@@H]1CCN(C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(C)=O)[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00001a019
44293810 108530 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Inhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesInhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranes
ChEMBL 581 5 2 4 5.4 Cc1cccc(NC(=O)NC2N=C(c3ccccc3F)c3cccc(C)c3N(CC(=O)N3CC4CCC(CC4)C3)C2=O)c1 10.1016/S0960-894X(96)00609-9
CHEMBL299800 108530 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Inhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesInhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranes
ChEMBL 581 5 2 4 5.4 Cc1cccc(NC(=O)NC2N=C(c3ccccc3F)c3cccc(C)c3N(CC(=O)N3CC4CCC(CC4)C3)C2=O)c1 10.1016/S0960-894X(96)00609-9
10369805 107328 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 532 5 3 3 5.6 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2c1ccccc1 10.1016/0960-894X(95)00327-P
CHEMBL291458 107328 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 532 5 3 3 5.6 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2c1ccccc1 10.1016/0960-894X(95)00327-P
10369805 107328 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 532 5 3 3 5.6 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2c1ccccc1 10.1021/jm00048a015
CHEMBL291458 107328 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 532 5 3 3 5.6 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2c1ccccc1 10.1021/jm00048a015
44348650 119883 0 None - 0 Bovine 9.3 pIC50 = 9.3 Binding
Inhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatumInhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatum
ChEMBL 986 24 11 11 2.0 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1cccc(NC(=O)[C@H](Cc2ccc(S(=O)(=O)O)cc2)NC(=O)O)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00099a005
CHEMBL331408 119883 0 None - 0 Bovine 9.3 pIC50 = 9.3 Binding
Inhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatumInhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatum
ChEMBL 986 24 11 11 2.0 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1cccc(NC(=O)[C@H](Cc2ccc(S(=O)(=O)O)cc2)NC(=O)O)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00099a005
10414170 177397 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 515 5 2 4 4.3 O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N2CCCC2)C1=O 10.1016/S0960-894X(00)80683-6
CHEMBL445095 177397 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 515 5 2 4 4.3 O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N2CCCC2)C1=O 10.1016/S0960-894X(00)80683-6
10414170 177397 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 515 5 2 4 4.3 O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N2CCCC2)C1=O 10.1021/jm00121a004
CHEMBL445095 177397 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 515 5 2 4 4.3 O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N2CCCC2)C1=O 10.1021/jm00121a004
15666988 114036 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 976 29 10 11 1.6 CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
CHEMBL316949 114036 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 976 29 10 11 1.6 CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
14888718 84027 0 None - 0 Bovine 9.3 pIC50 = 9.3 Binding
Inhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranesInhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranes
ChEMBL 1041 29 11 14 -0.1 CSCC[C@H](NC(=O)[C@H](Cc1ccc(-c2nn[nH]n2)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00107a037
CHEMBL2079606 84027 0 None - 0 Bovine 9.3 pIC50 = 9.3 Binding
Inhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranesInhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranes
ChEMBL 1041 29 11 14 -0.1 CSCC[C@H](NC(=O)[C@H](Cc1ccc(-c2nn[nH]n2)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00107a037
23815458 174574 1 None - 0 Rat 9.3 pIC50 = 9.3 Binding
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 483 5 3 5 4.2 CC(C)(C)C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(N)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm960669+
CHEMBL430516 174574 1 None - 0 Rat 9.3 pIC50 = 9.3 Binding
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 483 5 3 5 4.2 CC(C)(C)C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(N)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm960669+
903 9798 9 None - 1 Mouse 9.3 pIC50 = 9.3 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1021/jm00057a005
9850711 9798 9 None - 1 Mouse 9.3 pIC50 = 9.3 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1021/jm00057a005
CHEMBL138534 9798 9 None - 1 Mouse 9.3 pIC50 = 9.3 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1021/jm00057a005
CHEMBL2111312 9798 9 None - 1 Mouse 9.3 pIC50 = 9.3 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1021/jm00057a005
21842317 128458 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 482 5 2 4 4.9 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1016/0960-894X(95)00556-9
CHEMBL358646 128458 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 482 5 2 4 4.9 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1016/0960-894X(95)00556-9
21842317 128458 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligandBinding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligand
ChEMBL 482 5 2 4 4.9 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1016/0960-894X(95)00557-A
CHEMBL358646 128458 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligandBinding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligand
ChEMBL 482 5 2 4 4.9 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1016/0960-894X(95)00557-A
10322988 16920 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 482 5 2 4 4.9 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm960669+
CHEMBL115772 16920 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 482 5 2 4 4.9 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm960669+
10478703 126690 1 None - 1 Human 9.3 pIC50 = 9.3 Binding
Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.
ChEMBL 445 2 2 4 4.0 Cc1cccc(NC(=O)NC2N=C(N3CC4CCC(CC4)C3)c3ccccc3N(C)C2=O)c1 10.1021/jm00032a002
CHEMBL349291 126690 1 None - 1 Human 9.3 pIC50 = 9.3 Binding
Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.
ChEMBL 445 2 2 4 4.0 Cc1cccc(NC(=O)NC2N=C(N3CC4CCC(CC4)C3)c3ccccc3N(C)C2=O)c1 10.1021/jm00032a002
10323637 112963 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 498 7 2 5 3.6 CCN(CC)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C)c2)N=C(c2ccccn2)c2ccccc21 10.1021/jm00078a018
CHEMBL313813 112963 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 498 7 2 5 3.6 CCN(CC)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C)c2)N=C(c2ccccn2)c2ccccc21 10.1021/jm00078a018
10323637 112963 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 498 7 2 5 3.6 CCN(CC)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C)c2)N=C(c2ccccn2)c2ccccc21 10.1021/jm9608523
CHEMBL313813 112963 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 498 7 2 5 3.6 CCN(CC)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C)c2)N=C(c2ccccn2)c2ccccc21 10.1021/jm9608523
21842400 127752 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 496 7 2 4 5.3 CCC(C)(C)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C)c2)N=C(c2ccccc2)c2ccccc21 10.1016/0960-894X(95)00556-9
CHEMBL356191 127752 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 496 7 2 4 5.3 CCC(C)(C)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C)c2)N=C(c2ccccc2)c2ccccc21 10.1016/0960-894X(95)00556-9
9806412 211672 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranesBinding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranes
ChEMBL 511 5 3 6 2.9 CN1C(=O)C(NC(=O)Nc2cccc(C(=O)NS(C)(=O)=O)c2)N=C(C2CCCCC2)c2ccccc21 10.1016/0960-894X(95)00399-E
CHEMBL75892 211672 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranesBinding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranes
ChEMBL 511 5 3 6 2.9 CN1C(=O)C(NC(=O)Nc2cccc(C(=O)NS(C)(=O)=O)c2)N=C(C2CCCCC2)c2ccccc21 10.1016/0960-894X(95)00399-E
10814625 90242 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesInhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranes
ChEMBL 481 5 3 7 2.9 CN1C(=O)[C@H](NC(=O)Nc2cccc(N(C)c3nn[nH]n3)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm9506736
CHEMBL22003 90242 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesInhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranes
ChEMBL 481 5 3 7 2.9 CN1C(=O)[C@H](NC(=O)Nc2cccc(N(C)c3nn[nH]n3)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm9506736
155540415 179718 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1862 71 17 23 3.6 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4516868 179718 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1862 71 17 23 3.6 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
18957759 109794 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranesBinding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranes
ChEMBL 573 6 3 6 4.3 CN1C(=O)C(NC(=O)Nc2cccc(C(=O)NS(=O)(=O)c3ccccc3)c2)N=C(C2CCCCC2)c2ccccc21 10.1016/0960-894X(95)00399-E
CHEMBL306944 109794 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranesBinding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranes
ChEMBL 573 6 3 6 4.3 CN1C(=O)C(NC(=O)Nc2cccc(C(=O)NS(=O)(=O)c3ccccc3)c2)N=C(C2CCCCC2)c2ccccc21 10.1016/0960-894X(95)00399-E
15667014 114035 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 976 28 10 11 1.5 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
CHEMBL316944 114035 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 976 28 10 11 1.5 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
10673307 117413 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 511 7 3 5 4.2 CC(C)(C)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(NC=O)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm960669+
CHEMBL325746 117413 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 511 7 3 5 4.2 CC(C)(C)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(NC=O)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm960669+
44300745 205130 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 562 6 3 5 5.3 COC(=O)c1cccc(NC(=O)N[C@@H]2C[C@H](C3CCCCC3)c3ccc(C)cc3N(CC(=O)NC(C)(C)C)C2=O)c1 10.1016/0960-894X(95)00327-P
CHEMBL57643 205130 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 562 6 3 5 5.3 COC(=O)c1cccc(NC(=O)N[C@@H]2C[C@H](C3CCCCC3)c3ccc(C)cc3N(CC(=O)NC(C)(C)C)C2=O)c1 10.1016/0960-894X(95)00327-P
CHEMBL1806526 215751 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]CCK from gastrin receptor isolated from human tumor tissuesDisplacement of [125I]CCK from gastrin receptor isolated from human tumor tissues
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CO)NC(=O)[C@@H](CO)NC(=O)[C@@H](CO)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm101279a
162657745 187795 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I][3-iodo Tyr12,Leu15]gastrin-I from human CCK2R expressed in human A431 cells measured after 1 hr by gamma counter analysisDisplacement of [125I][3-iodo Tyr12,Leu15]gastrin-I from human CCK2R expressed in human A431 cells measured after 1 hr by gamma counter analysis
ChEMBL 1475 37 14 19 -1.1 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 10.1021/acs.jmedchem.0c01233
CHEMBL4759105 187795 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I][3-iodo Tyr12,Leu15]gastrin-I from human CCK2R expressed in human A431 cells measured after 1 hr by gamma counter analysisDisplacement of [125I][3-iodo Tyr12,Leu15]gastrin-I from human CCK2R expressed in human A431 cells measured after 1 hr by gamma counter analysis
ChEMBL 1475 37 14 19 -1.1 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 10.1021/acs.jmedchem.0c01233
9984739 121592 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 538 5 3 3 6.2 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2C1CCCCC1 10.1021/jm00048a015
CHEMBL334100 121592 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 538 5 3 3 6.2 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2C1CCCCC1 10.1021/jm00048a015
10369336 123533 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 517 7 2 4 4.5 CCN(CC)C(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL337574 123533 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 517 7 2 4 4.5 CCN(CC)C(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
10480792 52574 0 None - 0 Mouse 9.2 pIC50 = 9.2 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 9 4 4 4.5 CC1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
CHEMBL153095 52574 0 None - 0 Mouse 9.2 pIC50 = 9.2 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 9 4 4 4.5 CC1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
CHEMBL3350686 52574 0 None - 0 Mouse 9.2 pIC50 = 9.2 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 9 4 4 4.5 CC1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
10009526 117280 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Compound was evaluated for the inhibition of 124 I-CCK-8 binding at CCK-B receptor Cholecystokinin type B receptor cerebral cortical membranesCompound was evaluated for the inhibition of 124 I-CCK-8 binding at CCK-B receptor Cholecystokinin type B receptor cerebral cortical membranes
ChEMBL 655 6 3 7 4.6 O=C(Nc1cccc(-c2nn[nH]n2)c1)NC1N=C(c2ccccc2F)c2cccc(Cl)c2N(CC(=O)N2CC3CCC(CC3)C2)C1=O 10.1016/s0960-894x(98)00237-6
CHEMBL32492 117280 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Compound was evaluated for the inhibition of 124 I-CCK-8 binding at CCK-B receptor Cholecystokinin type B receptor cerebral cortical membranesCompound was evaluated for the inhibition of 124 I-CCK-8 binding at CCK-B receptor Cholecystokinin type B receptor cerebral cortical membranes
ChEMBL 655 6 3 7 4.6 O=C(Nc1cccc(-c2nn[nH]n2)c1)NC1N=C(c2ccccc2F)c2cccc(Cl)c2N(CC(=O)N2CC3CCC(CC3)C2)C1=O 10.1016/s0960-894x(98)00237-6
145992870 173667 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting methodDisplacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting method
ChEMBL 475 7 4 7 3.8 CCOc1ccc(-n2c(NNC(=S)Nc3cccc(C(=O)O)c3)nc3ccccc3c2=O)cc1 10.1039/C7MD00171A
CHEMBL4286087 173667 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting methodDisplacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting method
ChEMBL 475 7 4 7 3.8 CCOc1ccc(-n2c(NNC(=S)Nc3cccc(C(=O)O)c3)nc3ccccc3c2=O)cc1 10.1039/C7MD00171A
10484212 106655 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Compound was evaluated for the inhibition of 124 I-CCK-8 binding at Cholecystokinin type B receptor on guinea pig cerebral cortical membranesCompound was evaluated for the inhibition of 124 I-CCK-8 binding at Cholecystokinin type B receptor on guinea pig cerebral cortical membranes
ChEMBL 635 6 3 7 4.3 Cc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(-c3nn[nH]n3)c1)N=C2c1ccccc1F 10.1016/s0960-894x(98)00237-6
CHEMBL285921 106655 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Compound was evaluated for the inhibition of 124 I-CCK-8 binding at Cholecystokinin type B receptor on guinea pig cerebral cortical membranesCompound was evaluated for the inhibition of 124 I-CCK-8 binding at Cholecystokinin type B receptor on guinea pig cerebral cortical membranes
ChEMBL 635 6 3 7 4.3 Cc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(-c3nn[nH]n3)c1)N=C2c1ccccc1F 10.1016/s0960-894x(98)00237-6
10484212 106655 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesInhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranes
ChEMBL 635 6 3 7 4.3 Cc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(-c3nn[nH]n3)c1)N=C2c1ccccc1F 10.1016/S0960-894X(96)00609-9
CHEMBL285921 106655 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesInhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranes
ChEMBL 635 6 3 7 4.3 Cc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(-c3nn[nH]n3)c1)N=C2c1ccccc1F 10.1016/S0960-894X(96)00609-9
44301015 205840 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 609 7 5 7 3.7 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)Nc3nn[nH]n3)c1)C[C@@H]2c1ccccc1 10.1016/0960-894X(95)00327-P
CHEMBL58658 205840 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 609 7 5 7 3.7 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)Nc3nn[nH]n3)c1)C[C@@H]2c1ccccc1 10.1016/0960-894X(95)00327-P
CHEMBL1806772 215757 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]CCK from gastrin receptor isolated from human tumor tissuesDisplacement of [125I]CCK from gastrin receptor isolated from human tumor tissues
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm101279a
6439414 9799 14 None 2454 2 Mouse 9.2 pIC50 = 9.2 Binding
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptor
ChEMBL 612 11 5 5 4.6 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)/C=C/C(=O)O 10.1021/jm00105a062
867 9799 14 None 2454 2 Mouse 9.2 pIC50 = 9.2 Binding
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptor
ChEMBL 612 11 5 5 4.6 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)/C=C/C(=O)O 10.1021/jm00105a062
CHEMBL3351022 9799 14 None 2454 2 Mouse 9.2 pIC50 = 9.2 Binding
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptor
ChEMBL 612 11 5 5 4.6 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)/C=C/C(=O)O 10.1021/jm00105a062
CHEMBL341460 9799 14 None 2454 2 Mouse 9.2 pIC50 = 9.2 Binding
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptor
ChEMBL 612 11 5 5 4.6 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)/C=C/C(=O)O 10.1021/jm00105a062
44368728 126284 0 None - 0 Mouse 9.2 pIC50 = 9.2 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 596 11 5 4 4.3 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)C1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)/C=C/C(=O)O)c1ccccc1 10.1021/jm00057a005
CHEMBL345512 126284 0 None - 0 Mouse 9.2 pIC50 = 9.2 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 596 11 5 4 4.3 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)C1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)/C=C/C(=O)O)c1ccccc1 10.1021/jm00057a005
CHEMBL2370335 216609 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL None None None CCC[C@@H]1CCN(C(=O)[C@@H]2Cc3c[nH]c4cccc(c34)CC(=O)N2)[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(96)00546-X
18656023 111659 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranesBinding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranes
ChEMBL 573 6 3 6 4.3 CN1C(=O)[C@H](NC(=O)Nc2cccc(C(=O)NS(=O)(=O)c3ccccc3)c2)N=C(C2CCCCC2)c2ccccc21 10.1016/0960-894X(95)00399-E
CHEMBL311154 111659 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranesBinding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranes
ChEMBL 573 6 3 6 4.3 CN1C(=O)[C@H](NC(=O)Nc2cccc(C(=O)NS(=O)(=O)c3ccccc3)c2)N=C(C2CCCCC2)c2ccccc21 10.1016/0960-894X(95)00399-E
18656022 211577 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranesBinding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranes
ChEMBL 539 6 3 6 3.6 CC(C)S(=O)(=O)NC(=O)c1cccc(NC(=O)N[C@@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 10.1016/0960-894X(95)00399-E
CHEMBL75019 211577 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranesBinding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranes
ChEMBL 539 6 3 6 3.6 CC(C)S(=O)(=O)NC(=O)c1cccc(NC(=O)N[C@@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 10.1016/0960-894X(95)00399-E
CHEMBL407057 219414 0 None 120 4 Human 9.1 pIC50 = 9.1 Binding
Binding affinity towards Cholecystokinin type B receptor was determined in guinea pig cortex using [3H]SNF8702 as radioligandBinding affinity towards Cholecystokinin type B receptor was determined in guinea pig cortex using [3H]SNF8702 as radioligand
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O 10.1021/jm960078j
44369595 175306 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligandBinding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligand
ChEMBL 475 7 2 7 4.2 Cc1cccc(NCNC2N=C(c3nccs3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1016/0960-894X(95)00557-A
CHEMBL435447 175306 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligandBinding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligand
ChEMBL 475 7 2 7 4.2 Cc1cccc(NCNC2N=C(c3nccs3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1016/0960-894X(95)00557-A
CHEMBL1806527 215752 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]CCK from gastrin receptor isolated from human tumor tissuesDisplacement of [125I]CCK from gastrin receptor isolated from human tumor tissues
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm101279a
9853654 29561 41 None -31 2 Mouse 9.1 pIC50 = 9.1 Binding
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00092a007
CHEMBL1328 29561 41 None -31 2 Mouse 9.1 pIC50 = 9.1 Binding
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00092a007
14802543 177258 0 None - 0 Mouse 9.1 pIC50 = 9.1 Binding
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptor
ChEMBL 600 11 5 5 4.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NC[C@H](NC(=O)CC(=O)O)c1ccccc1 10.1021/jm00105a062
CHEMBL2112693 177258 0 None - 0 Mouse 9.1 pIC50 = 9.1 Binding
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptor
ChEMBL 600 11 5 5 4.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NC[C@H](NC(=O)CC(=O)O)c1ccccc1 10.1021/jm00105a062
CHEMBL444902 177258 0 None - 0 Mouse 9.1 pIC50 = 9.1 Binding
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptor
ChEMBL 600 11 5 5 4.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NC[C@H](NC(=O)CC(=O)O)c1ccccc1 10.1021/jm00105a062
9853654 29561 41 None -31 2 Mouse 9.1 pIC50 = 9.1 Binding
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00105a062
CHEMBL1328 29561 41 None -31 2 Mouse 9.1 pIC50 = 9.1 Binding
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00105a062
14802525 123505 1 None - 0 Mouse 9.1 pIC50 = 9.1 Binding
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 626 12 5 5 4.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](CNC(=O)/C=C/C(=O)O)Cc1ccccc1 10.1021/jm00105a062
CHEMBL337384 123505 1 None - 0 Mouse 9.1 pIC50 = 9.1 Binding
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 626 12 5 5 4.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](CNC(=O)/C=C/C(=O)O)Cc1ccccc1 10.1021/jm00105a062
10392653 125819 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 544 5 2 5 3.4 CN1CCN(C(=O)CN2C(=O)C(NC(=O)Nc3ccc(Cl)cc3)N=C(c3ccccc3)c3ccccc32)CC1 10.1021/jm00078a018
CHEMBL342640 125819 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 544 5 2 5 3.4 CN1CCN(C(=O)CN2C(=O)C(NC(=O)Nc3ccc(Cl)cc3)N=C(c3ccccc3)c3ccccc32)CC1 10.1021/jm00078a018
9853654 29561 41 None -31 2 Mouse 9.1 pIC50 = 9.1 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00057a005
CHEMBL1328 29561 41 None -31 2 Mouse 9.1 pIC50 = 9.1 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00057a005
44368613 127780 0 None - 0 Mouse 9.1 pIC50 = 9.1 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 610 12 5 4 4.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)C1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CNC(=O)/C=C/C(=O)O)Cc1ccccc1 10.1021/jm00057a005
CHEMBL356419 127780 0 None - 0 Mouse 9.1 pIC50 = 9.1 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 610 12 5 4 4.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)C1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CNC(=O)/C=C/C(=O)O)Cc1ccccc1 10.1021/jm00057a005
44300852 108748 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 566 6 4 6 4.1 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(-c3nn[nH]n3)c1)C[C@@H]2c1ccccc1 10.1016/0960-894X(95)00327-P
CHEMBL301418 108748 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 566 6 4 6 4.1 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(-c3nn[nH]n3)c1)C[C@@H]2c1ccccc1 10.1016/0960-894X(95)00327-P
10009450 106642 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Compound was evaluated for the inhibition of 124 I-CCK-8 binding at Cholecystokinin type B receptor on guinea pig cerebral cortical membranesCompound was evaluated for the inhibition of 124 I-CCK-8 binding at Cholecystokinin type B receptor on guinea pig cerebral cortical membranes
ChEMBL 649 7 3 7 4.5 CCc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(-c3nn[nH]n3)c1)N=C2c1ccccc1F 10.1016/s0960-894x(98)00237-6
CHEMBL285850 106642 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Compound was evaluated for the inhibition of 124 I-CCK-8 binding at Cholecystokinin type B receptor on guinea pig cerebral cortical membranesCompound was evaluated for the inhibition of 124 I-CCK-8 binding at Cholecystokinin type B receptor on guinea pig cerebral cortical membranes
ChEMBL 649 7 3 7 4.5 CCc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(-c3nn[nH]n3)c1)N=C2c1ccccc1F 10.1016/s0960-894x(98)00237-6
44293998 195203 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesInhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranes
ChEMBL 609 6 2 5 5.3 CC(=O)c1cccc(NC(=O)NC2N=C(c3ccccc3F)c3cccc(C)c3N(CC(=O)N3CC4CCC(CC4)C3)C2=O)c1 10.1016/S0960-894X(96)00609-9
CHEMBL50215 195203 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesInhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranes
ChEMBL 609 6 2 5 5.3 CC(=O)c1cccc(NC(=O)NC2N=C(c3ccccc3F)c3cccc(C)c3N(CC(=O)N3CC4CCC(CC4)C3)C2=O)c1 10.1016/S0960-894X(96)00609-9
22883501 17193 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 552 6 2 6 5.0 CC(C)(C)C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(N3CCCCC3)c2)N=C(c2ccccn2)c2ccccc21 10.1021/jm960669+
CHEMBL116300 17193 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 552 6 2 6 5.0 CC(C)(C)C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(N3CCCCC3)c2)N=C(c2ccccn2)c2ccccc21 10.1021/jm960669+
21842353 127810 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 550 7 2 4 6.5 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C3CCCCC3)C2=O)c1 10.1016/0960-894X(95)00556-9
CHEMBL356631 127810 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 550 7 2 4 6.5 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C3CCCCC3)C2=O)c1 10.1016/0960-894X(95)00556-9
44300863 205128 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 619 7 4 6 3.7 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)NS(C)(=O)=O)c1)C[C@@H]2c1ccccc1 10.1016/0960-894X(95)00327-P
CHEMBL57642 205128 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 619 7 4 6 3.7 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)NS(C)(=O)=O)c1)C[C@@H]2c1ccccc1 10.1016/0960-894X(95)00327-P
44300891 206333 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 586 7 4 6 5.1 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(-c3nn[nH]n3)c1)C[C@@H]2CC1CCCCC1 10.1016/0960-894X(95)00327-P
CHEMBL59234 206333 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 586 7 4 6 5.1 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(-c3nn[nH]n3)c1)C[C@@H]2CC1CCCCC1 10.1016/0960-894X(95)00327-P
15281185 56228 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligandBinding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligand
ChEMBL 484 5 2 6 3.7 Cc1cccc(NC(=O)NC2N=C(c3cnccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1016/0960-894X(95)00557-A
CHEMBL156484 56228 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligandBinding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligand
ChEMBL 484 5 2 6 3.7 Cc1cccc(NC(=O)NC2N=C(c3cnccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1016/0960-894X(95)00557-A
155524181 177632 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1820 71 18 22 2.7 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4453982 177632 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1820 71 18 22 2.7 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL1807151 215758 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]CCK from gastrin receptor isolated from human tumor tissuesDisplacement of [125I]CCK from gastrin receptor isolated from human tumor tissues
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CO)NC(=O)[C@@H](CO)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm101279a
162673067 189922 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I][3-iodo Tyr12,Leu15]gastrin-I from human CCK2R expressed in human A431 cells measured after 1 hr by gamma counter analysisDisplacement of [125I][3-iodo Tyr12,Leu15]gastrin-I from human CCK2R expressed in human A431 cells measured after 1 hr by gamma counter analysis
ChEMBL 1403 38 16 20 -3.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.0c01233
CHEMBL4795198 189922 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I][3-iodo Tyr12,Leu15]gastrin-I from human CCK2R expressed in human A431 cells measured after 1 hr by gamma counter analysisDisplacement of [125I][3-iodo Tyr12,Leu15]gastrin-I from human CCK2R expressed in human A431 cells measured after 1 hr by gamma counter analysis
ChEMBL 1403 38 16 20 -3.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.0c01233
CHEMBL2310858 216269 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL None None None CCCC1CCN([C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc2ccccc2)C(N)=O)[C@H]1C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)CCc1ccc(OS(=O)(=O)O)cc1 10.1021/jm00094a001
44348901 148606 0 None - 0 Bovine 9.0 pIC50 = 9.0 Binding
Inhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatumInhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatum
ChEMBL 1000 24 11 11 2.3 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1cccc(NC(=O)[C@H](Cc2ccc(S(=O)(=O)O)cc2)NC(=O)O)c1C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00099a005
CHEMBL386376 148606 0 None - 0 Bovine 9.0 pIC50 = 9.0 Binding
Inhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatumInhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatum
ChEMBL 1000 24 11 11 2.3 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1cccc(NC(=O)[C@H](Cc2ccc(S(=O)(=O)O)cc2)NC(=O)O)c1C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00099a005
4627 7609 50 None -1 5 Human 9.0 pIC50 = 9.0 Binding
Displacement of radiolabeled CCK-8s from human CCK2 receptorDisplacement of radiolabeled CCK-8s from human CCK2 receptor
ChEMBL None None None None 10.1021/jm8007618
864 7609 50 None -1 5 Human 9.0 pIC50 = 9.0 Binding
Displacement of radiolabeled CCK-8s from human CCK2 receptorDisplacement of radiolabeled CCK-8s from human CCK2 receptor
ChEMBL None None None None 10.1021/jm8007618
9833444 7609 50 None -1 5 Human 9.0 pIC50 = 9.0 Binding
Displacement of radiolabeled CCK-8s from human CCK2 receptorDisplacement of radiolabeled CCK-8s from human CCK2 receptor
ChEMBL None None None None 10.1021/jm8007618
CHEMBL1121 7609 50 None -1 5 Human 9.0 pIC50 = 9.0 Binding
Displacement of radiolabeled CCK-8s from human CCK2 receptorDisplacement of radiolabeled CCK-8s from human CCK2 receptor
ChEMBL None None None None 10.1021/jm8007618
DB09142 7609 50 None -1 5 Human 9.0 pIC50 = 9.0 Binding
Displacement of radiolabeled CCK-8s from human CCK2 receptorDisplacement of radiolabeled CCK-8s from human CCK2 receptor
ChEMBL None None None None 10.1021/jm8007618
10031259 11071 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL 586 12 3 4 4.3 O=C(Cc1c[nH]c2ccccc12)N[C@@H](Cc1ccccc1)C(=O)N(CCC1CCCCC1)CC(=O)N1CCC[C@H]1C(=O)O 10.1016/S0960-894X(96)00546-X
CHEMBL100799 11071 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL 586 12 3 4 4.3 O=C(Cc1c[nH]c2ccccc12)N[C@@H](Cc1ccccc1)C(=O)N(CCC1CCCCC1)CC(=O)N1CCC[C@H]1C(=O)O 10.1016/S0960-894X(96)00546-X
44396655 128828 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibition of 125I]-BH-(Thr,Nle)-CCK-9 binding to human CCK2 receptor expressed in COS-7 cellsInhibition of 125I]-BH-(Thr,Nle)-CCK-9 binding to human CCK2 receptor expressed in COS-7 cells
ChEMBL 608 8 2 5 5.7 C[C@H]1C(=O)N(Cc2ccccc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC3C4CC5CC(C4)CC3C5)C12 10.1021/jm0498755
CHEMBL359589 128828 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibition of 125I]-BH-(Thr,Nle)-CCK-9 binding to human CCK2 receptor expressed in COS-7 cellsInhibition of 125I]-BH-(Thr,Nle)-CCK-9 binding to human CCK2 receptor expressed in COS-7 cells
ChEMBL 608 8 2 5 5.7 C[C@H]1C(=O)N(Cc2ccccc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC3C4CC5CC(C4)CC3C5)C12 10.1021/jm0498755
44293971 195812 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesInhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranes
ChEMBL 611 6 3 5 4.8 Cc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(C(=O)O)c1)N=C2c1ccccc1F 10.1016/S0960-894X(96)00609-9
CHEMBL50926 195812 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesInhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranes
ChEMBL 611 6 3 5 4.8 Cc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(C(=O)O)c1)N=C2c1ccccc1F 10.1016/S0960-894X(96)00609-9
44300889 107538 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 532 6 4 6 3.8 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(-c3nn[nH]n3)c1)C[C@@H]2C(C)C 10.1016/0960-894X(95)00327-P
CHEMBL292856 107538 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 532 6 4 6 3.8 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(-c3nn[nH]n3)c1)C[C@@H]2C(C)C 10.1016/0960-894X(95)00327-P
10744557 39500 0 None - 0 Mouse 9.0 pIC50 = 9 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 521 7 4 4 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1CCCCC1C(=O)O 10.1021/jm970065l
CHEMBL141370 39500 0 None - 0 Mouse 9.0 pIC50 = 9 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 521 7 4 4 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1CCCCC1C(=O)O 10.1021/jm970065l
10435698 148186 0 None - 0 Human 9.0 pIC50 = 9 Binding
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 490 6 2 5 4.2 CCOC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80683-6
CHEMBL38404 148186 0 None - 0 Human 9.0 pIC50 = 9 Binding
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 490 6 2 5 4.2 CCOC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80683-6
44301037 107634 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 633 8 4 6 4.0 CCS(=O)(=O)NC(=O)c1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)c3ccc(C)cc3N(CC(=O)NC(C)(C)C)C2=O)c1 10.1016/0960-894X(95)00327-P
CHEMBL293490 107634 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 633 8 4 6 4.0 CCS(=O)(=O)NC(=O)c1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)c3ccc(C)cc3N(CC(=O)NC(C)(C)C)C2=O)c1 10.1016/0960-894X(95)00327-P
10814373 213882 0 None - 0 Mouse 9.0 pIC50 = 9 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 474 7 3 8 4.2 CC(C)Oc1cccc(-n2c(NNC(=O)Nc3cccc([N+](=O)[O-])c3)nc3ccccc3c2=O)c1 10.1021/jm970373j
CHEMBL9203 213882 0 None - 0 Mouse 9.0 pIC50 = 9 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 474 7 3 8 4.2 CC(C)Oc1cccc(-n2c(NNC(=O)Nc3cccc([N+](=O)[O-])c3)nc3ccccc3c2=O)c1 10.1021/jm970373j
10435698 148186 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 490 6 2 5 4.2 CCOC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00121a004
CHEMBL38404 148186 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 490 6 2 5 4.2 CCOC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00121a004
9853654 29561 41 None 31 2 Human 9.0 pIC50 = 9 Binding
Displacement of [125I][3-iodo Tyr12,Leu15]gastrin-I from human CCK2R expressed in human A431 cells measured after 1 hr by gamma counter analysisDisplacement of [125I][3-iodo Tyr12,Leu15]gastrin-I from human CCK2R expressed in human A431 cells measured after 1 hr by gamma counter analysis
ChEMBL 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.0c01233
CHEMBL1328 29561 41 None 31 2 Human 9.0 pIC50 = 9 Binding
Displacement of [125I][3-iodo Tyr12,Leu15]gastrin-I from human CCK2R expressed in human A431 cells measured after 1 hr by gamma counter analysisDisplacement of [125I][3-iodo Tyr12,Leu15]gastrin-I from human CCK2R expressed in human A431 cells measured after 1 hr by gamma counter analysis
ChEMBL 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.0c01233
10369805 107328 0 None - 0 Human 9.0 pIC50 = 9 Binding
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 532 5 3 3 5.6 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2c1ccccc1 10.1021/jm00048a015
CHEMBL291458 107328 0 None - 0 Human 9.0 pIC50 = 9 Binding
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 532 5 3 3 5.6 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2c1ccccc1 10.1021/jm00048a015
44293999 195204 0 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesInhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranes
ChEMBL 597 6 2 5 5.1 COc1cccc(NC(=O)NC2N=C(c3ccccc3F)c3cccc(C)c3N(CC(=O)N3CC4CCC(CC4)C3)C2=O)c1 10.1016/S0960-894X(96)00609-9
CHEMBL50216 195204 0 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesInhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranes
ChEMBL 597 6 2 5 5.1 COc1cccc(NC(=O)NC2N=C(c3ccccc3F)c3cccc(C)c3N(CC(=O)N3CC4CCC(CC4)C3)C2=O)c1 10.1016/S0960-894X(96)00609-9
10074702 34387 0 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 500 8 2 6 4.0 CCOC(=O)CCN1C(=O)C(NC(=O)Nc2cccc(OC)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL136966 34387 0 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 500 8 2 6 4.0 CCOC(=O)CCN1C(=O)C(NC(=O)Nc2cccc(OC)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
10435698 148186 0 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 490 6 2 5 4.2 CCOC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL38404 148186 0 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 490 6 2 5 4.2 CCOC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
4627 7609 50 None 1 5 Rat 9.0 pIC50 = 9 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL None None None None 10.1021/jm00079a003
864 7609 50 None 1 5 Rat 9.0 pIC50 = 9 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL None None None None 10.1021/jm00079a003
9833444 7609 50 None 1 5 Rat 9.0 pIC50 = 9 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL None None None None 10.1021/jm00079a003
CHEMBL1121 7609 50 None 1 5 Rat 9.0 pIC50 = 9 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL None None None None 10.1021/jm00079a003
DB09142 7609 50 None 1 5 Rat 9.0 pIC50 = 9 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL None None None None 10.1021/jm00079a003
44376112 126971 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
The compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligandThe compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligand
ChEMBL 452 4 3 6 2.8 CN1C(=O)[C@@H](NC(=O)Nc2ccc(-c3nn[nH]n3)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00032a003
CHEMBL351854 126971 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
The compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligandThe compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligand
ChEMBL 452 4 3 6 2.8 CN1C(=O)[C@@H](NC(=O)Nc2ccc(-c3nn[nH]n3)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00032a003
10007047 23695 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 524 5 3 3 5.8 CC(C)(C)NC(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](C2CCCCC2)c2ccccc21 10.1021/jm00048a015
CHEMBL125253 23695 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 524 5 3 3 5.8 CC(C)(C)NC(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](C2CCCCC2)c2ccccc21 10.1021/jm00048a015
CHEMBL218327 216173 0 None -2 4 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
5311201 214174 35 None -27 6 Human 9.0 pIC50 = 9.0 Binding
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00121a004
CHEMBL9387 214174 35 None -27 6 Human 9.0 pIC50 = 9.0 Binding
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00121a004
15667019 215008 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 905 26 9 10 2.0 CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCNC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
CHEMBL98631 215008 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 905 26 9 10 2.0 CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCNC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
10576729 66004 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesInhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranes
ChEMBL 481 5 4 7 3.2 Cc1ccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc1Nc1nn[nH]n1 10.1021/jm9506736
CHEMBL170275 66004 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesInhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranes
ChEMBL 481 5 4 7 3.2 Cc1ccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc1Nc1nn[nH]n1 10.1021/jm9506736
5311201 214174 35 None -27 6 Human 9.0 pIC50 = 9.0 Binding
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00164a020
CHEMBL9387 214174 35 None -27 6 Human 9.0 pIC50 = 9.0 Binding
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00164a020
10789887 214206 0 None - 0 Mouse 8.9 pIC50 = 8.9 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 454 6 3 7 4.2 CC(C)Oc1cccc(-n2c(NNC(=O)Nc3cccc(C#N)c3)nc3ccccc3c2=O)c1 10.1021/jm970373j
CHEMBL9405 214206 0 None - 0 Mouse 8.9 pIC50 = 8.9 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 454 6 3 7 4.2 CC(C)Oc1cccc(-n2c(NNC(=O)Nc3cccc(C#N)c3)nc3ccccc3c2=O)c1 10.1021/jm970373j
10075014 169760 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 508 6 2 5 4.4 CCOC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00121a004
CHEMBL417521 169760 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 508 6 2 5 4.4 CCOC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00121a004
10075014 169760 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 508 6 2 5 4.4 CCOC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00078a018
CHEMBL417521 169760 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 508 6 2 5 4.4 CCOC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00078a018
44368562 128741 0 None - 0 Mouse 8.9 pIC50 = 8.9 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 588 12 5 5 4.3 C[C@H]1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CNC(=O)/C=C/C(=O)O)Cc1ccccc1 10.1021/jm00057a005
CHEMBL359076 128741 0 None - 0 Mouse 8.9 pIC50 = 8.9 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 588 12 5 5 4.3 C[C@H]1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CNC(=O)/C=C/C(=O)O)Cc1ccccc1 10.1021/jm00057a005
10696336 212114 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 487 5 3 4 4.6 CCCN1C(=O)[C@H](NC(=O)Nc2ccc3c(c2)CCC3)N=C([C@H]2CC(C)(C)CCN2)c2ccccc21 10.1021/jm9608523
CHEMBL79565 212114 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 487 5 3 4 4.6 CCCN1C(=O)[C@H](NC(=O)Nc2ccc3c(c2)CCC3)N=C([C@H]2CC(C)(C)CCN2)c2ccccc21 10.1021/jm9608523
10364786 111648 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.
ChEMBL 419 2 2 4 3.7 Cc1cccc(NC(=O)NC2N=C(N3CCCCCC3)c3ccccc3N(C)C2=O)c1 10.1021/jm00032a002
CHEMBL311061 111648 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.
ChEMBL 419 2 2 4 3.7 Cc1cccc(NC(=O)NC2N=C(N3CCCCCC3)c3ccccc3N(C)C2=O)c1 10.1021/jm00032a002
10768084 16791 1 None - 0 Rat 8.9 pIC50 = 8.9 Binding
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 512 6 2 6 4.1 CN(C)c1cccc(NC(=O)N[C@H]2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm960669+
CHEMBL114991 16791 1 None - 0 Rat 8.9 pIC50 = 8.9 Binding
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 512 6 2 6 4.1 CN(C)c1cccc(NC(=O)N[C@H]2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm960669+
10815039 119624 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 493 5 2 5 4.5 CC(C)(C)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C#N)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm960669+
CHEMBL330917 119624 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 493 5 2 5 4.5 CC(C)(C)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C#N)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm960669+
162658676 187761 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I][3-iodo Tyr12,Leu15]gastrin-I from human CCK2R expressed in human A431 cells measured after 1 hr by gamma counter analysisDisplacement of [125I][3-iodo Tyr12,Leu15]gastrin-I from human CCK2R expressed in human A431 cells measured after 1 hr by gamma counter analysis
ChEMBL 1489 37 14 19 -0.7 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 10.1021/acs.jmedchem.0c01233
CHEMBL4758706 187761 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I][3-iodo Tyr12,Leu15]gastrin-I from human CCK2R expressed in human A431 cells measured after 1 hr by gamma counter analysisDisplacement of [125I][3-iodo Tyr12,Leu15]gastrin-I from human CCK2R expressed in human A431 cells measured after 1 hr by gamma counter analysis
ChEMBL 1489 37 14 19 -0.7 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 10.1021/acs.jmedchem.0c01233
71450869 91159 0 None - 0 Mouse 8.9 pIC50 = 8.9 Binding
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 650 12 5 6 4.3 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCS(=O)(=O)O)c1ccccc1 10.1021/jm00092a007
CHEMBL2112338 91159 0 None - 0 Mouse 8.9 pIC50 = 8.9 Binding
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 650 12 5 6 4.3 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCS(=O)(=O)O)c1ccccc1 10.1021/jm00092a007
CHEMBL2219559 91159 0 None - 0 Mouse 8.9 pIC50 = 8.9 Binding
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 650 12 5 6 4.3 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCS(=O)(=O)O)c1ccccc1 10.1021/jm00092a007
4627 7609 50 None - 5 Mouse 8.9 pIC50 = 8.9 Binding
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL None None None None 10.1016/s0960-894x(01)00044-0
864 7609 50 None - 5 Mouse 8.9 pIC50 = 8.9 Binding
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL None None None None 10.1016/s0960-894x(01)00044-0
9833444 7609 50 None - 5 Mouse 8.9 pIC50 = 8.9 Binding
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL None None None None 10.1016/s0960-894x(01)00044-0
CHEMBL1121 7609 50 None - 5 Mouse 8.9 pIC50 = 8.9 Binding
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL None None None None 10.1016/s0960-894x(01)00044-0
DB09142 7609 50 None - 5 Mouse 8.9 pIC50 = 8.9 Binding
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL None None None None 10.1016/s0960-894x(01)00044-0
10364786 111648 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 419 2 2 4 3.7 Cc1cccc(NC(=O)NC2N=C(N3CCCCCC3)c3ccccc3N(C)C2=O)c1 10.1021/jm9608523
CHEMBL311061 111648 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 419 2 2 4 3.7 Cc1cccc(NC(=O)NC2N=C(N3CCCCCC3)c3ccccc3N(C)C2=O)c1 10.1021/jm9608523
10251516 20145 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.
ChEMBL 419 2 2 4 3.7 Cc1cccc(NC(=O)N[C@@H]2N=C(N3CCCCCC3)c3ccccc3N(C)C2=O)c1 10.1021/jm00032a002
CHEMBL1192472 20145 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.
ChEMBL 419 2 2 4 3.7 Cc1cccc(NC(=O)N[C@@H]2N=C(N3CCCCCC3)c3ccccc3N(C)C2=O)c1 10.1021/jm00032a002
CHEMBL543712 20145 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.
ChEMBL 419 2 2 4 3.7 Cc1cccc(NC(=O)N[C@@H]2N=C(N3CCCCCC3)c3ccccc3N(C)C2=O)c1 10.1021/jm00032a002
44301034 108364 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 556 6 3 5 4.8 COC(=O)c1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)c3ccc(C)cc3N(CC(=O)NC(C)(C)C)C2=O)c1 10.1016/0960-894X(95)00327-P
CHEMBL298627 108364 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 556 6 3 5 4.8 COC(=O)c1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)c3ccc(C)cc3N(CC(=O)NC(C)(C)C)C2=O)c1 10.1016/0960-894X(95)00327-P
44210535 109776 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranesBinding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranes
ChEMBL 434 4 3 4 3.9 CN1C(=O)C(NC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1016/0960-894X(95)00399-E
CHEMBL306803 109776 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranesBinding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranes
ChEMBL 434 4 3 4 3.9 CN1C(=O)C(NC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1016/0960-894X(95)00399-E
162673242 189987 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I][3-iodo Tyr12,Leu15]gastrin-I from human CCK2R expressed in human A431 cells measured after 1 hr by gamma counter analysisDisplacement of [125I][3-iodo Tyr12,Leu15]gastrin-I from human CCK2R expressed in human A431 cells measured after 1 hr by gamma counter analysis
ChEMBL 1475 37 14 19 -1.1 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 10.1021/acs.jmedchem.0c01233
CHEMBL4795913 189987 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I][3-iodo Tyr12,Leu15]gastrin-I from human CCK2R expressed in human A431 cells measured after 1 hr by gamma counter analysisDisplacement of [125I][3-iodo Tyr12,Leu15]gastrin-I from human CCK2R expressed in human A431 cells measured after 1 hr by gamma counter analysis
ChEMBL 1475 37 14 19 -1.1 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 10.1021/acs.jmedchem.0c01233
15667012 175829 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 976 28 10 11 1.5 CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
CHEMBL439591 175829 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 976 28 10 11 1.5 CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
10482588 25314 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 546 6 3 3 5.8 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2Cc1ccccc1 10.1021/jm00048a015
CHEMBL127521 25314 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 546 6 3 3 5.8 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2Cc1ccccc1 10.1021/jm00048a015
10436569 84620 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 515 5 2 4 4.3 O=C(Nc1ccc(Cl)cc1)N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(=O)N2CCCC2)C1=O 10.1021/jm00078a018
CHEMBL2092976 84620 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 515 5 2 4 4.3 O=C(Nc1ccc(Cl)cc1)N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(=O)N2CCCC2)C1=O 10.1021/jm00078a018
10791546 213862 0 None - 0 Mouse 8.8 pIC50 = 8.8 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 501 8 3 8 4.5 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(OC(C)C)c2)c1 10.1021/jm970373j
CHEMBL9188 213862 0 None - 0 Mouse 8.8 pIC50 = 8.8 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 501 8 3 8 4.5 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(OC(C)C)c2)c1 10.1021/jm970373j
10346998 24882 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 532 5 2 3 5.7 CN(C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](c2ccccc2)c2ccccc21)C(C)(C)C 10.1021/jm00048a015
CHEMBL126865 24882 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 532 5 2 3 5.7 CN(C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](c2ccccc2)c2ccccc21)C(C)(C)C 10.1021/jm00048a015
10837729 113222 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 461 5 3 4 4.5 CCCN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C([C@H]2CC(C)(C)CCN2)c2ccccc21 10.1021/jm9608523
CHEMBL313983 113222 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 461 5 3 4 4.5 CCCN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C([C@H]2CC(C)(C)CCN2)c2ccccc21 10.1021/jm9608523
CHEMBL206974 215961 0 None 1 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
21842365 126532 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligandBinding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligand
ChEMBL 495 6 2 5 4.5 Cc1cccc(NC(=O)NC2N=C(c3cccnc3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1016/0960-894X(95)00557-A
CHEMBL347843 126532 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligandBinding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligand
ChEMBL 495 6 2 5 4.5 Cc1cccc(NC(=O)NC2N=C(c3cccnc3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1016/0960-894X(95)00557-A
4627 7609 50 None -1 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptorDisplacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptor
ChEMBL None None None None 10.1016/S0960-894X(00)80680-0
864 7609 50 None -1 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptorDisplacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptor
ChEMBL None None None None 10.1016/S0960-894X(00)80680-0
9833444 7609 50 None -1 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptorDisplacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptor
ChEMBL None None None None 10.1016/S0960-894X(00)80680-0
CHEMBL1121 7609 50 None -1 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptorDisplacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptor
ChEMBL None None None None 10.1016/S0960-894X(00)80680-0
DB09142 7609 50 None -1 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptorDisplacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptor
ChEMBL None None None None 10.1016/S0960-894X(00)80680-0
CHEMBL1806530 215754 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]CCK from gastrin receptor isolated from human tumor tissuesDisplacement of [125I]CCK from gastrin receptor isolated from human tumor tissues
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm101279a
10414170 177397 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 515 5 2 4 4.3 O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N2CCCC2)C1=O 10.1021/jm00078a018
CHEMBL445095 177397 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 515 5 2 4 4.3 O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N2CCCC2)C1=O 10.1021/jm00078a018
CHEMBL382349 219081 0 None 1 4 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
52949124 7663 4 None 2 2 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I-CCK] from human CCK2R H7.39L mutant expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-CCK] from human CCK2R H7.39L mutant expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
9055 7663 4 None 2 2 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I-CCK] from human CCK2R H7.39L mutant expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-CCK] from human CCK2R H7.39L mutant expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
CHEMBL1269258 7663 4 None 2 2 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I-CCK] from human CCK2R H7.39L mutant expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-CCK] from human CCK2R H7.39L mutant expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
DB12694 7663 4 None 2 2 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I-CCK] from human CCK2R H7.39L mutant expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-CCK] from human CCK2R H7.39L mutant expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
44300890 108667 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 580 7 4 6 4.3 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(-c3nn[nH]n3)c1)C[C@@H]2Cc1ccccc1 10.1016/0960-894X(95)00327-P
CHEMBL300776 108667 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 580 7 4 6 4.3 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(-c3nn[nH]n3)c1)C[C@@H]2Cc1ccccc1 10.1016/0960-894X(95)00327-P
108187 7713 37 None -9 5 Mouse 8.8 pIC50 = 8.8 Binding
Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1016/S0960-894X(00)80273-5
873 7713 37 None -9 5 Mouse 8.8 pIC50 = 8.8 Binding
Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1016/S0960-894X(00)80273-5
CHEMBL2062154 7713 37 None -9 5 Mouse 8.8 pIC50 = 8.8 Binding
Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1016/S0960-894X(00)80273-5
CHEMBL287735 7713 37 None -9 5 Mouse 8.8 pIC50 = 8.8 Binding
Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1016/S0960-894X(00)80273-5
155534566 178754 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter methodDisplacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter method
ChEMBL 1409 38 15 21 -2.2 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)Cn1cc([C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)nn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.9b01936
CHEMBL4470833 178754 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter methodDisplacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter method
ChEMBL 1409 38 15 21 -2.2 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)Cn1cc([C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)nn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.9b01936
59923871 80735 1 None - 0 Mouse 8.8 pIC50 = 8.8 Binding
Evaluated for in vitro binding affinity towards cholecystokinin-B (CCK-B) receptor in mouse cerebral cortex using [125I]bolton hunter CCK-26-33 as radioligand; 1.3-2.7Evaluated for in vitro binding affinity towards cholecystokinin-B (CCK-B) receptor in mouse cerebral cortex using [125I]bolton hunter CCK-26-33 as radioligand; 1.3-2.7
ChEMBL 614 12 5 5 4.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCC(NC(=O)CCC(=O)O)c1ccccc1 10.1016/S0960-894X(00)80156-0
CHEMBL2021374 80735 1 None - 0 Mouse 8.8 pIC50 = 8.8 Binding
Evaluated for in vitro binding affinity towards cholecystokinin-B (CCK-B) receptor in mouse cerebral cortex using [125I]bolton hunter CCK-26-33 as radioligand; 1.3-2.7Evaluated for in vitro binding affinity towards cholecystokinin-B (CCK-B) receptor in mouse cerebral cortex using [125I]bolton hunter CCK-26-33 as radioligand; 1.3-2.7
ChEMBL 614 12 5 5 4.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCC(NC(=O)CCC(=O)O)c1ccccc1 10.1016/S0960-894X(00)80156-0
71452691 85404 0 None - 0 Mouse 8.8 pIC50 = 8.8 Binding
Evaluated for inhibition of CCK-B receptor by displacing [125I]bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of CCK-B receptor by displacing [125I]bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 671 12 5 7 3.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)C[S+]([O-])c1nc[nH]n1)c1ccccc1 10.1021/jm00092a007
CHEMBL2112336 85404 0 None - 0 Mouse 8.8 pIC50 = 8.8 Binding
Evaluated for inhibition of CCK-B receptor by displacing [125I]bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of CCK-B receptor by displacing [125I]bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 671 12 5 7 3.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)C[S+]([O-])c1nc[nH]n1)c1ccccc1 10.1021/jm00092a007
14802538 103464 0 None - 0 Mouse 8.8 pIC50 = 8.8 Binding
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 614 12 5 5 4.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCC(=O)O)c1ccccc1 10.1021/jm00092a007
CHEMBL263969 103464 0 None - 0 Mouse 8.8 pIC50 = 8.8 Binding
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 614 12 5 5 4.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCC(=O)O)c1ccccc1 10.1021/jm00092a007
108187 7713 37 None -9 5 Mouse 8.8 pIC50 = 8.8 Binding
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptor
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm00105a062
873 7713 37 None -9 5 Mouse 8.8 pIC50 = 8.8 Binding
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptor
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm00105a062
CHEMBL2062154 7713 37 None -9 5 Mouse 8.8 pIC50 = 8.8 Binding
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptor
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm00105a062
CHEMBL287735 7713 37 None -9 5 Mouse 8.8 pIC50 = 8.8 Binding
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptor
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm00105a062
14802537 92763 0 None - 0 Mouse 8.8 pIC50 = 8.8 Binding
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 614 12 5 5 4.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NC[C@@H](NC(=O)CCC(=O)O)c1ccccc1 10.1016/S0960-894X(01)80769-1
CHEMBL2304062 92763 0 None - 0 Mouse 8.8 pIC50 = 8.8 Binding
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 614 12 5 5 4.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NC[C@@H](NC(=O)CCC(=O)O)c1ccccc1 10.1016/S0960-894X(01)80769-1
108187 7713 37 None -9 5 Mouse 8.8 pIC50 = 8.8 Binding
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1016/S0960-894X(00)80685-X
873 7713 37 None -9 5 Mouse 8.8 pIC50 = 8.8 Binding
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1016/S0960-894X(00)80685-X
CHEMBL2062154 7713 37 None -9 5 Mouse 8.8 pIC50 = 8.8 Binding
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1016/S0960-894X(00)80685-X
CHEMBL287735 7713 37 None -9 5 Mouse 8.8 pIC50 = 8.8 Binding
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1016/S0960-894X(00)80685-X
14802538 103464 0 None - 0 Mouse 8.8 pIC50 = 8.8 Binding
Inhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptorInhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptor
ChEMBL 614 12 5 5 4.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCC(=O)O)c1ccccc1 10.1016/s0960-894x(98)00677-5
CHEMBL263969 103464 0 None - 0 Mouse 8.8 pIC50 = 8.8 Binding
Inhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptorInhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptor
ChEMBL 614 12 5 5 4.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCC(=O)O)c1ccccc1 10.1016/s0960-894x(98)00677-5
108187 7713 37 None -9 5 Mouse 8.8 pIC50 = 8.8 Binding
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1016/S0960-894X(97)00356-9
873 7713 37 None -9 5 Mouse 8.8 pIC50 = 8.8 Binding
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1016/S0960-894X(97)00356-9
CHEMBL2062154 7713 37 None -9 5 Mouse 8.8 pIC50 = 8.8 Binding
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1016/S0960-894X(97)00356-9
CHEMBL287735 7713 37 None -9 5 Mouse 8.8 pIC50 = 8.8 Binding
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1016/S0960-894X(97)00356-9
44368727 126283 0 None - 0 Mouse 8.8 pIC50 = 8.8 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 598 12 5 4 4.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)C1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1 10.1021/jm00057a005
CHEMBL345511 126283 0 None - 0 Mouse 8.8 pIC50 = 8.8 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 598 12 5 4 4.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)C1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1 10.1021/jm00057a005
108187 7713 37 None -9 5 Mouse 8.8 pIC50 = 8.8 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm970065l
873 7713 37 None -9 5 Mouse 8.8 pIC50 = 8.8 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm970065l
CHEMBL2062154 7713 37 None -9 5 Mouse 8.8 pIC50 = 8.8 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm970065l
CHEMBL287735 7713 37 None -9 5 Mouse 8.8 pIC50 = 8.8 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm970065l
14802539 83327 1 None - 1 Mouse 8.8 pIC50 = 8.8 Binding
The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the mouse cerebral cortex (CCK-B);value ranges from 1.3-3.7The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the mouse cerebral cortex (CCK-B);value ranges from 1.3-3.7
ChEMBL 614 12 5 5 4.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1 10.1016/S0960-894X(00)80652-6
CHEMBL2062144 83327 1 None - 1 Mouse 8.8 pIC50 = 8.8 Binding
The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the mouse cerebral cortex (CCK-B);value ranges from 1.3-3.7The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the mouse cerebral cortex (CCK-B);value ranges from 1.3-3.7
ChEMBL 614 12 5 5 4.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1 10.1016/S0960-894X(00)80652-6
CHEMBL35471 218512 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cellsBinding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cells
ChEMBL None None None CCS[C@@H]1CCN(C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(C)=O)[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00001a019
44293812 108492 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesInhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranes
ChEMBL 645 5 2 4 5.9 Cc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(Br)c1)N=C2c1ccccc1F 10.1016/S0960-894X(96)00609-9
CHEMBL299523 108492 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesInhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranes
ChEMBL 645 5 2 4 5.9 Cc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(Br)c1)N=C2c1ccccc1F 10.1016/S0960-894X(96)00609-9
44348651 175016 0 None - 0 Bovine 8.7 pIC50 = 8.7 Binding
Inhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatumInhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatum
ChEMBL 952 26 11 11 0.6 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCNC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00099a005
CHEMBL433647 175016 0 None - 0 Bovine 8.7 pIC50 = 8.7 Binding
Inhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatumInhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatum
ChEMBL 952 26 11 11 0.6 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCNC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00099a005
9866980 11428 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortexDisplacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortex
ChEMBL 423 3 2 4 4.6 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N3C[C@H](C)N=C23)c1 10.1016/0960-894X(95)00530-0
CHEMBL103119 11428 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortexDisplacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortex
ChEMBL 423 3 2 4 4.6 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N3C[C@H](C)N=C23)c1 10.1016/0960-894X(95)00530-0
155553502 180954 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1822 72 19 22 3.0 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OP(=O)(O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4547294 180954 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1822 72 19 22 3.0 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OP(=O)(O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
21842326 128069 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 496 8 2 4 5.3 CCC(CC)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C)c2)N=C(c2ccccc2)c2ccccc21 10.1016/0960-894X(95)00556-9
CHEMBL358000 128069 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 496 8 2 4 5.3 CCC(CC)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C)c2)N=C(c2ccccc2)c2ccccc21 10.1016/0960-894X(95)00556-9
9936789 213368 0 None - 0 Mouse 8.7 pIC50 = 8.7 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 529 7 3 8 5.3 CC(C)Oc1cccc(-n2c(NNC(=O)Nc3cccc(C(=O)OC(C)(C)C)c3)nc3ccccc3c2=O)c1 10.1021/jm970373j
CHEMBL8890 213368 0 None - 0 Mouse 8.7 pIC50 = 8.7 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 529 7 3 8 5.3 CC(C)Oc1cccc(-n2c(NNC(=O)Nc3cccc(C(=O)OC(C)(C)C)c3)nc3ccccc3c2=O)c1 10.1021/jm970373j
44303664 107485 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Compound was tested for its binding affinity towards Cholecystokinin type B receptor in cortical membranes (CNS)Compound was tested for its binding affinity towards Cholecystokinin type B receptor in cortical membranes (CNS)
ChEMBL 661 16 7 7 0.3 CCCC1C[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)N(C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)CN)C1 10.1016/S0960-894X(01)81005-2
CHEMBL292493 107485 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Compound was tested for its binding affinity towards Cholecystokinin type B receptor in cortical membranes (CNS)Compound was tested for its binding affinity towards Cholecystokinin type B receptor in cortical membranes (CNS)
ChEMBL 661 16 7 7 0.3 CCCC1C[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)N(C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)CN)C1 10.1016/S0960-894X(01)81005-2
CHEMBL3143186 217918 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Compound was tested for its inhibitory activity in cortical cholecystokinin type B receptor in guinea pigCompound was tested for its inhibitory activity in cortical cholecystokinin type B receptor in guinea pig
ChEMBL None None None CCC[C@@H]1CCN(C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)[C@@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00105a068
52949124 7663 4 None 2 2 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I-BDZ-2] from human CCK2R H7.39L mutant expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-BDZ-2] from human CCK2R H7.39L mutant expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
9055 7663 4 None 2 2 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I-BDZ-2] from human CCK2R H7.39L mutant expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-BDZ-2] from human CCK2R H7.39L mutant expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
CHEMBL1269258 7663 4 None 2 2 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I-BDZ-2] from human CCK2R H7.39L mutant expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-BDZ-2] from human CCK2R H7.39L mutant expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
DB12694 7663 4 None 2 2 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I-BDZ-2] from human CCK2R H7.39L mutant expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-BDZ-2] from human CCK2R H7.39L mutant expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
10623795 214063 0 None - 0 Mouse 8.0 pIC50 = 8 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 459 7 3 7 4.3 COc1ccccc1NC(=O)NNc1nc2ccccc2c(=O)n1-c1cccc(OC(C)C)c1 10.1021/jm970373j
CHEMBL9319 214063 0 None - 0 Mouse 8.0 pIC50 = 8 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 459 7 3 7 4.3 COc1ccccc1NC(=O)NNc1nc2ccccc2c(=O)n1-c1cccc(OC(C)C)c1 10.1021/jm970373j
9960432 46198 5 None 12 2 Human 8.0 pIC50 = 8 Binding
Compound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transfected with cDNA of human Cholecystokinin type B receptorCompound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transfected with cDNA of human Cholecystokinin type B receptor
ChEMBL 605 8 3 5 5.0 CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C(=O)O)c2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/jm9601664
CHEMBL147186 46198 5 None 12 2 Human 8.0 pIC50 = 8 Binding
Compound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transfected with cDNA of human Cholecystokinin type B receptorCompound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transfected with cDNA of human Cholecystokinin type B receptor
ChEMBL 605 8 3 5 5.0 CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C(=O)O)c2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/jm9601664
46235271 80423 2 None -2 2 Human 8.0 pIC50 = 8 Binding
Displacement of [125I-BDZ-2] from human CCK2R H7.39L mutant expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-BDZ-2] from human CCK2R H7.39L mutant expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 649 7 1 6 6.7 Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 10.1021/acs.jmedchem.5b01110
CHEMBL2017835 80423 2 None -2 2 Human 8.0 pIC50 = 8 Binding
Displacement of [125I-BDZ-2] from human CCK2R H7.39L mutant expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-BDZ-2] from human CCK2R H7.39L mutant expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 649 7 1 6 6.7 Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 10.1021/acs.jmedchem.5b01110
15667011 103432 1 None - 0 Human 8.0 pIC50 = 8 Binding
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 990 29 9 11 2.0 CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
CHEMBL263742 103432 1 None - 0 Human 8.0 pIC50 = 8 Binding
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 990 29 9 11 2.0 CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
10102593 148283 2 None - 0 Human 8.0 pIC50 = 8 Binding
In vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranesIn vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranes
ChEMBL 1048 29 10 12 3.3 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 10.1016/S0960-894X(00)80679-4
CHEMBL384505 148283 2 None - 0 Human 8.0 pIC50 = 8 Binding
In vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranesIn vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranes
ChEMBL 1048 29 10 12 3.3 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 10.1016/S0960-894X(00)80679-4
44333048 176036 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranesInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranes
ChEMBL 1032 28 10 11 3.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 10.1021/jm00072a024
CHEMBL441165 176036 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranesInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranes
ChEMBL 1032 28 10 11 3.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 10.1021/jm00072a024
44329342 115206 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 571 7 3 5 5.5 Cc1ccccc1[C@H]1C[C@@H](NC(=O)Nc2cccc([N+](=O)[O-])c2)C(=O)N(CC(=O)NC(C)(C)C)[C@@H](c2ccccc2)C1 10.1016/S0960-894X(01)80832-5
CHEMBL319882 115206 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 571 7 3 5 5.5 Cc1ccccc1[C@H]1C[C@@H](NC(=O)Nc2cccc([N+](=O)[O-])c2)C(=O)N(CC(=O)NC(C)(C)C)[C@@H](c2ccccc2)C1 10.1016/S0960-894X(01)80832-5
10255357 25290 0 None - 0 Human 8.0 pIC50 = 8 Binding
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 498 5 3 3 5.0 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)c3ccccc3N(CC(=O)NC(C)(C)C)C2=O)c1 10.1021/jm00048a015
CHEMBL127397 25290 0 None - 0 Human 8.0 pIC50 = 8 Binding
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 498 5 3 3 5.0 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)c3ccccc3N(CC(=O)NC(C)(C)C)C2=O)c1 10.1021/jm00048a015
10393441 178492 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 580 7 3 3 6.5 CC(C)(NC(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](c2ccccc2)c2ccccc21)c1ccccc1 10.1021/jm00048a015
CHEMBL446682 178492 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 580 7 3 3 6.5 CC(C)(NC(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](c2ccccc2)c2ccccc21)c1ccccc1 10.1021/jm00048a015
10102593 148283 2 None - 0 Rat 7.0 pIC50 = 7 Binding
In vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic aciniIn vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic acini
ChEMBL 1048 29 10 12 3.3 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 10.1016/S0960-894X(00)80679-4
CHEMBL384505 148283 2 None - 0 Rat 7.0 pIC50 = 7 Binding
In vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic aciniIn vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic acini
ChEMBL 1048 29 10 12 3.3 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 10.1016/S0960-894X(00)80679-4
14843042 134353 0 None - 0 Mouse 7.0 pIC50 = 7 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 485 5 1 3 6.5 CCc1cccc(-n2c(CC(C)c3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
CHEMBL36634 134353 0 None - 0 Mouse 7.0 pIC50 = 7 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 485 5 1 3 6.5 CCc1cccc(-n2c(CC(C)c3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
9983680 170102 0 None - 0 Human 7.0 pIC50 = 7 Binding
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 506 7 2 5 3.8 Cc1cccc(NC(=O)N[C@H](COC(=O)N2CCCC2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
CHEMBL418987 170102 0 None - 0 Human 7.0 pIC50 = 7 Binding
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 506 7 2 5 3.8 Cc1cccc(NC(=O)N[C@H](COC(=O)N2CCCC2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
5311148 8677 7 None - 0 Human 6.0 pIC50 = 6 Binding
Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8
ChEMBL 587 8 1 5 5.9 COc1ccc(cc1)N(C(=O)CN1C(=O)C(Cc2[nH]nc3c2cccc3)C(=O)N(c2c1cccc2)c1ccccc1)C(C)C 10.1021/jm960249k
865 8677 7 None - 0 Human 6.0 pIC50 = 6 Binding
Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8
ChEMBL 587 8 1 5 5.9 COc1ccc(cc1)N(C(=O)CN1C(=O)C(Cc2[nH]nc3c2cccc3)C(=O)N(c2c1cccc2)c1ccccc1)C(C)C 10.1021/jm960249k
CHEMBL293226 8677 7 None - 0 Human 6.0 pIC50 = 6 Binding
Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8
ChEMBL 587 8 1 5 5.9 COc1ccc(cc1)N(C(=O)CN1C(=O)C(Cc2[nH]nc3c2cccc3)C(=O)N(c2c1cccc2)c1ccccc1)C(C)C 10.1021/jm960249k
CHEMBL3142686 217908 0 None - 0 Human 6.0 pIC50 = 6 Binding
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL None None None CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
44306823 209846 0 None - 0 Human 6.0 pIC50 = 6 Binding
Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes
ChEMBL 802 20 9 7 2.8 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NC(CCCCNC(=O)Nc1ccccc1Cl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccc(C)cc1)C(N)=O 10.1021/jm00001a027
CHEMBL63707 209846 0 None - 0 Human 6.0 pIC50 = 6 Binding
Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes
ChEMBL 802 20 9 7 2.8 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NC(CCCCNC(=O)Nc1ccccc1Cl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccc(C)cc1)C(N)=O 10.1021/jm00001a027
15689733 113391 0 None - 0 Human 6.0 pIC50 = 6 Binding
Displacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL 870 21 9 10 3.0 COC(=O)c1cccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c1 10.1021/jm960509y
CHEMBL3142905 113391 0 None - 0 Human 6.0 pIC50 = 6 Binding
Displacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL 870 21 9 10 3.0 COC(=O)c1cccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c1 10.1021/jm960509y
155515427 176728 0 None - 0 Human 6.0 pIC50 = 6 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1886 72 17 23 4.2 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4441596 176728 0 None - 0 Human 6.0 pIC50 = 6 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1886 72 17 23 4.2 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL1172246 215360 0 None -1 4 Human 6.0 pIC50 = 6 Binding
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cells
ChEMBL None None None N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CC(=O)NCCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc2ccccc2)C(N)=O)NC(=O)[C@H](Cc2cc3ccccc3[nH]2)NC1=O 10.1016/j.bmcl.2010.05.078
21121108 88774 2 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranesIn vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranes
ChEMBL 1048 29 10 12 3.3 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 10.1016/S0960-894X(00)80679-4
CHEMBL216527 88774 2 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranesIn vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranes
ChEMBL 1048 29 10 12 3.3 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 10.1016/S0960-894X(00)80679-4
5311148 8677 7 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 587 8 1 5 5.9 COc1ccc(cc1)N(C(=O)CN1C(=O)C(Cc2[nH]nc3c2cccc3)C(=O)N(c2c1cccc2)c1ccccc1)C(C)C 10.1021/jm970265x
865 8677 7 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 587 8 1 5 5.9 COc1ccc(cc1)N(C(=O)CN1C(=O)C(Cc2[nH]nc3c2cccc3)C(=O)N(c2c1cccc2)c1ccccc1)C(C)C 10.1021/jm970265x
CHEMBL293226 8677 7 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 587 8 1 5 5.9 COc1ccc(cc1)N(C(=O)CN1C(=O)C(Cc2[nH]nc3c2cccc3)C(=O)N(c2c1cccc2)c1ccccc1)C(C)C 10.1021/jm970265x
14444015 113454 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 635 15 6 6 3.8 CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(=O)O)CC(=O)NCc1ccccc1 10.1021/jm00123a003
CHEMBL3143388 113454 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 635 15 6 6 3.8 CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(=O)O)CC(=O)NCc1ccccc1 10.1021/jm00123a003
44303224 148713 0 None - 0 Human 6.0 pIC50 = 6 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 933 23 8 11 2.8 CN(C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCNC(=O)/C=C/c1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL387073 148713 0 None - 0 Human 6.0 pIC50 = 6 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 933 23 8 11 2.8 CN(C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCNC(=O)/C=C/c1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
44349393 23606 0 None - 0 Rat 6.0 pIC50 = 6 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 422 7 3 3 4.3 O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NC1CCCCCCCCC1 10.1021/jm00079a003
CHEMBL124764 23606 0 None - 0 Rat 6.0 pIC50 = 6 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 422 7 3 3 4.3 O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NC1CCCCCCCCC1 10.1021/jm00079a003
CHEMBL285051 217641 0 None - 0 Human 5.0 pIC50 = 5 Binding
Binding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cellsBinding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cells
ChEMBL None None None CS[C@@H]1CCN(C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(C)=O)[C@@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00001a019
CHEMBL37786 219037 0 None - 0 Human 5.0 pIC50 = 5 Binding
Binding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cellsBinding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cells
ChEMBL None None None CS[C@H]1CCN(C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(C)=O)[C@@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00001a019
44382805 65986 0 None - 0 Mouse 5.0 pIC50 = 5 Binding
Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)
ChEMBL 536 9 3 5 3.4 CC(C)C[C@H](NC(=O)C(NC(=O)OC(C)(C)C)c1ccccc1)C(=O)N1CC(=O)N[C@@H](Cc2ccccc2)C1 10.1016/S0960-894X(01)80253-5
CHEMBL170197 65986 0 None - 0 Mouse 5.0 pIC50 = 5 Binding
Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)
ChEMBL 536 9 3 5 3.4 CC(C)C[C@H](NC(=O)C(NC(=O)OC(C)(C)C)c1ccccc1)C(=O)N1CC(=O)N[C@@H](Cc2ccccc2)C1 10.1016/S0960-894X(01)80253-5
44306888 109107 0 None - 1 Human 5.0 pIC50 = 5 Binding
Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes
ChEMBL 816 18 9 7 3.4 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NC(Cc1cccc(NC(=O)Nc2ccccc2C)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccc(C)cc1)C(N)=O 10.1021/jm00001a027
CHEMBL303635 109107 0 None - 1 Human 5.0 pIC50 = 5 Binding
Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes
ChEMBL 816 18 9 7 3.4 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NC(Cc1cccc(NC(=O)Nc2ccccc2C)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccc(C)cc1)C(N)=O 10.1021/jm00001a027
44408590 168505 0 None - 2 Human 5.0 pIC50 = 5 Binding
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1134 30 12 15 2.6 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)C(=O)O 10.1021/jm050851n
CHEMBL413644 168505 0 None - 2 Human 5.0 pIC50 = 5 Binding
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1134 30 12 15 2.6 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)C(=O)O 10.1021/jm050851n
44418923 168564 0 None - 2 Human 5.0 pIC50 = 5 Binding
Displacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1132 28 13 13 1.7 CCCC[C@H](NC(=O)[C@@H](Cc1cc2ccccc2[nH]1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061268p
CHEMBL414087 168564 0 None - 2 Human 5.0 pIC50 = 5 Binding
Displacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1132 28 13 13 1.7 CCCC[C@H](NC(=O)[C@@H](Cc1cc2ccccc2[nH]1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061268p
44375063 61895 0 None - 0 Mouse 5.0 pIC50 = 5 Binding
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 554 10 6 7 4.0 O=C(O)c1ccc(NS(=O)(=O)c2ccc(N/N=C(/S)NCCc3c[nH]c4ccccc34)c([N+](=O)[O-])c2)cc1 10.1016/s0960-894x(01)00044-0
CHEMBL161703 61895 0 None - 0 Mouse 5.0 pIC50 = 5 Binding
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 554 10 6 7 4.0 O=C(O)c1ccc(NS(=O)(=O)c2ccc(N/N=C(/S)NCCc3c[nH]c4ccccc34)c([N+](=O)[O-])c2)cc1 10.1016/s0960-894x(01)00044-0
14444011 113455 0 None - 0 Human 5.0 pIC50 = 5 Binding
In vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 692 17 7 7 2.7 CC(C)C[C@@H](CC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00123a003
CHEMBL3143393 113455 0 None - 0 Human 5.0 pIC50 = 5 Binding
In vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 692 17 7 7 2.7 CC(C)C[C@@H](CC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00123a003
44366341 126098 0 None - 0 Human 5.0 pIC50 = 5 Binding
In vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 649 16 6 6 3.8 CC(C)C[C@@H](CC(=O)NC(CC(=O)O)C(=O)NCCc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00123a003
CHEMBL344125 126098 0 None - 0 Human 5.0 pIC50 = 5 Binding
In vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 649 16 6 6 3.8 CC(C)C[C@@H](CC(=O)NC(CC(=O)O)C(=O)NCCc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00123a003
15104627 117255 0 None - 0 Human 5.0 pIC50 = 5 Binding
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 462 7 2 3 4.7 CN(Cc1ccccc1)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cnc2ccccc2c1 10.1021/jm00116a002
CHEMBL324760 117255 0 None - 0 Human 5.0 pIC50 = 5 Binding
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 462 7 2 3 4.7 CN(Cc1ccccc1)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cnc2ccccc2c1 10.1021/jm00116a002
44341327 170111 0 None - 0 Human 5.0 pIC50 = 5 Binding
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 504 13 3 2 6.3 CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cc2cc(F)ccc2[nH]1 10.1021/jm00116a002
CHEMBL419031 170111 0 None - 0 Human 5.0 pIC50 = 5 Binding
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 504 13 3 2 6.3 CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cc2cc(F)ccc2[nH]1 10.1021/jm00116a002
14991537 113573 0 None - 0 Human 5.0 pIC50 = 5 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 921 24 9 11 2.4 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCc1cccc(OS(=O)(=O)O)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL3144535 113573 0 None - 0 Human 5.0 pIC50 = 5 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 921 24 9 11 2.4 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCc1cccc(OS(=O)(=O)O)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
14991543 113583 0 None - 0 Human 5.0 pIC50 = 5 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 839 22 8 8 3.5 Cc1ccc(CCC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 10.1021/jm00089a010
CHEMBL3144544 113583 0 None - 0 Human 5.0 pIC50 = 5 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 839 22 8 8 3.5 Cc1ccc(CCC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 10.1021/jm00089a010
14991566 175012 0 None - 0 Human 5.0 pIC50 = 5 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 831 22 8 8 3.9 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCC1CCCCC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL433636 175012 0 None - 0 Human 5.0 pIC50 = 5 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 831 22 8 8 3.9 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCC1CCCCC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
10391834 44998 0 None - 0 Human 5.0 pIC50 = 5 Binding
Tested for 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecystokinin type B receptorTested for 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecystokinin type B receptor
ChEMBL 516 11 3 4 4.5 CC(C)N(C(=O)CN(C(=O)[C@@H](CCC(=O)O)NC(=O)Nc1ccccc1)c1ccccc1)c1ccccc1 10.1016/S0960-894X(97)00062-0
CHEMBL146206 44998 0 None - 0 Human 5.0 pIC50 = 5 Binding
Tested for 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecystokinin type B receptorTested for 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecystokinin type B receptor
ChEMBL 516 11 3 4 4.5 CC(C)N(C(=O)CN(C(=O)[C@@H](CCC(=O)O)NC(=O)Nc1ccccc1)c1ccccc1)c1ccccc1 10.1016/S0960-894X(97)00062-0
10556460 213518 0 None - 0 Human 4.0 pIC50 = 4 Binding
Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8
ChEMBL 677 10 0 6 7.4 COc1ccc(N(C(=O)CN2C(=O)C(Cc3nn(Cc4ccccc4)c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm960249k
CHEMBL89953 213518 0 None - 0 Human 4.0 pIC50 = 4 Binding
Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8
ChEMBL 677 10 0 6 7.4 COc1ccc(N(C(=O)CN2C(=O)C(Cc3nn(Cc4ccccc4)c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm960249k
44306360 164654 0 None - 1 Human 4.0 pIC50 = 4 Binding
Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes
ChEMBL 816 18 9 7 3.4 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NC(Cc1ccc(NC(=O)Nc2ccccc2C)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccc(C)cc1)C(N)=O 10.1021/jm00001a027
CHEMBL408395 164654 0 None - 1 Human 4.0 pIC50 = 4 Binding
Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes
ChEMBL 816 18 9 7 3.4 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NC(Cc1ccc(NC(=O)Nc2ccccc2C)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccc(C)cc1)C(N)=O 10.1021/jm00001a027
10556460 213518 0 None - 0 Human 4.0 pIC50 = 4 Binding
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 677 10 0 6 7.4 COc1ccc(N(C(=O)CN2C(=O)C(Cc3nn(Cc4ccccc4)c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm970265x
CHEMBL89953 213518 0 None - 0 Human 4.0 pIC50 = 4 Binding
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 677 10 0 6 7.4 COc1ccc(N(C(=O)CN2C(=O)C(Cc3nn(Cc4ccccc4)c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm970265x
14444013 113456 0 None - 0 Human 4.0 pIC50 = 4 Binding
In vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 692 17 7 7 2.7 CC(C)C[C@H](CC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00123a003
CHEMBL3143394 113456 0 None - 0 Human 4.0 pIC50 = 4 Binding
In vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 692 17 7 7 2.7 CC(C)C[C@H](CC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00123a003
44341429 117229 0 None - 0 Human 4.0 pIC50 = 4 Binding
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 498 13 2 3 6.3 CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccc2ccccc2n1 10.1021/jm00116a002
CHEMBL324652 117229 0 None - 0 Human 4.0 pIC50 = 4 Binding
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 498 13 2 3 6.3 CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccc2ccccc2n1 10.1021/jm00116a002
15167797 38430 0 None - 0 Human 4.0 pIC50 = 4 Binding
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 403 5 2 4 4.4 O=C(NCC1CNc2ccccc2C(c2ccccc2F)=N1)OCc1ccccc1 10.1021/jm00163a069
CHEMBL140495 38430 0 None - 0 Human 4.0 pIC50 = 4 Binding
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 403 5 2 4 4.4 O=C(NCC1CNc2ccccc2C(c2ccccc2F)=N1)OCc1ccccc1 10.1021/jm00163a069
20190196 38562 0 None - 0 Human 4.0 pIC50 = 4 Binding
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 388 4 1 4 3.3 CN1c2ccccc2C(c2ccccc2F)=NCC1CNC(=O)c1cccnc1 10.1021/jm00163a069
CHEMBL140620 38562 0 None - 0 Human 4.0 pIC50 = 4 Binding
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 388 4 1 4 3.3 CN1c2ccccc2C(c2ccccc2F)=NCC1CNC(=O)c1cccnc1 10.1021/jm00163a069
15614749 39019 0 None - 0 Human 4.0 pIC50 = 4 Binding
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 393 4 2 4 3.5 O=C(NCC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccsc1 10.1021/jm00163a069
CHEMBL140984 39019 0 None - 0 Human 4.0 pIC50 = 4 Binding
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 393 4 2 4 3.5 O=C(NCC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccsc1 10.1021/jm00163a069
44359880 39103 0 None - 0 Human 4.0 pIC50 = 4 Binding
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 428 7 2 5 2.4 CC(=O)NCSCC(=O)NCC1CN=C(c2ccccc2F)c2ccccc2N1C 10.1021/jm00163a069
CHEMBL141048 39103 0 None - 0 Human 4.0 pIC50 = 4 Binding
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 428 7 2 5 2.4 CC(=O)NCSCC(=O)NCC1CN=C(c2ccccc2F)c2ccccc2N1C 10.1021/jm00163a069
19766234 39110 0 None - 0 Human 4.0 pIC50 = 4 Binding
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 427 4 1 3 5.6 CN1c2ccccc2C(c2ccccc2F)=NCC1CNc1cccc(C(F)(F)F)c1 10.1021/jm00163a069
CHEMBL141051 39110 0 None - 0 Human 4.0 pIC50 = 4 Binding
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 427 4 1 3 5.6 CN1c2ccccc2C(c2ccccc2F)=NCC1CNc1cccc(C(F)(F)F)c1 10.1021/jm00163a069
20063245 122120 0 None - 0 Human 4.0 pIC50 = 4 Binding
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 417 5 2 4 3.9 O=C(NCC1N=C(c2ccccc2F)c2ccccc2NC1=O)OCc1ccccc1 10.1021/jm00163a069
CHEMBL334933 122120 0 None - 0 Human 4.0 pIC50 = 4 Binding
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 417 5 2 4 3.9 O=C(NCC1N=C(c2ccccc2F)c2ccccc2NC1=O)OCc1ccccc1 10.1021/jm00163a069
44359840 172227 0 None - 0 Human 4.0 pIC50 = 4 Binding
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 395 4 2 5 3.5 O=C1Nc2ccccc2C(c2ccccc2F)=NC1CNc1cnc(Cl)cn1 10.1021/jm00163a069
CHEMBL423918 172227 0 None - 0 Human 4.0 pIC50 = 4 Binding
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 395 4 2 5 3.5 O=C1Nc2ccccc2C(c2ccccc2F)=NC1CNc1cnc(Cl)cn1 10.1021/jm00163a069
44370505 58054 0 None - 0 Human 4.0 pIC50 = 4 Binding
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 543 10 2 4 6.3 O=C(CC[C@H](NC(=O)c1cc2ccccc2[nH]1)C(=O)N(C1CCCCC1)C1CCCCC1)OCc1ccccc1 10.1021/jm00164a020
CHEMBL158078 58054 0 None - 0 Human 4.0 pIC50 = 4 Binding
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 543 10 2 4 6.3 O=C(CC[C@H](NC(=O)c1cc2ccccc2[nH]1)C(=O)N(C1CCCCC1)C1CCCCC1)OCc1ccccc1 10.1021/jm00164a020
44280270 105994 0 None - 0 Human 7.0 pIC50 = 7 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 601 10 2 4 5.2 CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)[C@H](Cc1ccccc1)C(=O)O 10.1021/jm950372w
CHEMBL281560 105994 0 None - 0 Human 7.0 pIC50 = 7 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 601 10 2 4 5.2 CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)[C@H](Cc1ccccc1)C(=O)O 10.1021/jm950372w
44280193 109908 0 None - 0 Human 7.0 pIC50 = 7 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 672 13 3 5 5.1 CN(Cc1ccccc1)C(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL30784 109908 0 None - 0 Human 7.0 pIC50 = 7 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 672 13 3 5 5.1 CN(Cc1ccccc1)C(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
10474221 23621 0 None - 0 Rat 5.0 pIC50 = 5 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 368 8 3 3 2.9 CC(C)(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 10.1021/jm00079a003
CHEMBL124822 23621 0 None - 0 Rat 5.0 pIC50 = 5 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 368 8 3 3 2.9 CC(C)(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 10.1021/jm00079a003
44281084 119469 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 497 8 3 4 3.3 O=C(O)CNC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL33043 119469 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 497 8 3 4 3.3 O=C(O)CNC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
10482726 32913 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 551 7 3 4 5.0 O=C(CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21)NCc1ccccc1 10.1021/jm00078a018
CHEMBL135638 32913 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 551 7 3 4 5.0 O=C(CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21)NCc1ccccc1 10.1021/jm00078a018
44349278 23378 0 None - 0 Rat 5.0 pIC50 = 5.0 Binding
Concentration required to inhibit by 50% the specific binding of [125I](BH)-CCK-8 to CCK-B(B2) in rat brain cortexConcentration required to inhibit by 50% the specific binding of [125I](BH)-CCK-8 to CCK-B(B2) in rat brain cortex
ChEMBL 388 10 3 3 3.3 CCCCCNC(=O)C(CCC(=O)O)NC(=O)c1ccc(Cl)c(Cl)c1 10.1021/jm00079a003
CHEMBL124090 23378 0 None - 0 Rat 5.0 pIC50 = 5.0 Binding
Concentration required to inhibit by 50% the specific binding of [125I](BH)-CCK-8 to CCK-B(B2) in rat brain cortexConcentration required to inhibit by 50% the specific binding of [125I](BH)-CCK-8 to CCK-B(B2) in rat brain cortex
ChEMBL 388 10 3 3 3.3 CCCCCNC(=O)C(CCC(=O)O)NC(=O)c1ccc(Cl)c(Cl)c1 10.1021/jm00079a003
44349412 23637 0 None - 0 Rat 5.0 pIC50 = 5.0 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 396 12 3 3 3.6 CCCCC(CC)CNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 10.1021/jm00079a003
CHEMBL124917 23637 0 None - 0 Rat 5.0 pIC50 = 5.0 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 396 12 3 3 3.6 CCCCC(CC)CNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 10.1021/jm00079a003
44382371 127279 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 436 5 2 4 2.8 COc1cccc(NC(=O)N[C@@H]2CCc3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 10.1016/S0960-894X(00)80683-6
CHEMBL354442 127279 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 436 5 2 4 2.8 COc1cccc(NC(=O)N[C@@H]2CCc3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 10.1016/S0960-894X(00)80683-6
44281292 121572 0 None - 1 Mouse 7.0 pIC50 = 7.0 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 816 17 5 9 5.0 CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCCNC(=O)CC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
CHEMBL33398 121572 0 None - 1 Mouse 7.0 pIC50 = 7.0 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 816 17 5 9 5.0 CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCCNC(=O)CC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
44357198 122016 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 478 6 4 5 3.0 O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(C[C@@H](O)CO)C1=O 10.1021/jm00078a018
CHEMBL334735 122016 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 478 6 4 5 3.0 O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(C[C@@H](O)CO)C1=O 10.1021/jm00078a018
10603714 163297 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 605 8 1 5 6.0 COc1ccc(N(C(=O)CN2C(=O)C(Cc3n[nH]c4c(F)cccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm970265x
CHEMBL406790 163297 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 605 8 1 5 6.0 COc1ccc(N(C(=O)CN2C(=O)C(Cc3n[nH]c4c(F)cccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm970265x
44349325 175327 0 None - 0 Rat 5.0 pIC50 = 5.0 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 465 7 3 4 3.1 O=C(O)CCC(NC(=O)c1cccc(Br)c1)C(=O)NN1CCC2(CCCC2)CC1 10.1021/jm00079a003
CHEMBL435587 175327 0 None - 0 Rat 5.0 pIC50 = 5.0 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 465 7 3 4 3.1 O=C(O)CCC(NC(=O)c1cccc(Br)c1)C(=O)NN1CCC2(CCCC2)CC1 10.1021/jm00079a003
44280380 106616 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 553 11 3 4 4.8 CCCCC(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O 10.1021/jm950372w
CHEMBL285657 106616 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 553 11 3 4 4.8 CCCCC(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O 10.1021/jm950372w
44283087 127602 0 None - 0 Mouse 6.0 pIC50 = 6.0 Binding
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 500 8 2 4 5.8 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)OCCc1ccccc1 10.1021/jm00086a017
CHEMBL35580 127602 0 None - 0 Mouse 6.0 pIC50 = 6.0 Binding
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 500 8 2 4 5.8 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)OCCc1ccccc1 10.1021/jm00086a017
10249484 29426 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 385 3 2 4 3.0 CN1C(=O)C(NC(=O)Nc2ccncc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL132699 29426 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 385 3 2 4 3.0 CN1C(=O)C(NC(=O)Nc2ccncc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
10646538 104142 0 None - 0 Mouse 7.0 pIC50 = 7.0 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 435 6 3 6 4.1 CC(C)Oc1cccc(-n2c(NNC(=O)NC3CCCCC3)nc3ccccc3c2=O)c1 10.1021/jm970373j
CHEMBL269606 104142 0 None - 0 Mouse 7.0 pIC50 = 7.0 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 435 6 3 6 4.1 CC(C)Oc1cccc(-n2c(NNC(=O)NC3CCCCC3)nc3ccccc3c2=O)c1 10.1021/jm970373j
44280244 19998 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 695 12 4 6 5.6 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2cccnc12 10.1021/jm950372w
CHEMBL1191257 19998 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 695 12 4 6 5.6 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2cccnc12 10.1021/jm950372w
CHEMBL542330 19998 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 695 12 4 6 5.6 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2cccnc12 10.1021/jm950372w
44283055 106532 0 None - 0 Mouse 6.0 pIC50 = 6.0 Binding
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 515 9 4 4 4.4 O=C(NC(Cc1c[nH]c2ccccc12)C(=O)NC(CO)Cc1ccccc1)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
CHEMBL285049 106532 0 None - 0 Mouse 6.0 pIC50 = 6.0 Binding
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 515 9 4 4 4.4 O=C(NC(Cc1c[nH]c2ccccc12)C(=O)NC(CO)Cc1ccccc1)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
44283150 172024 0 None - 0 Mouse 6.0 pIC50 = 6.0 Binding
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 529 9 3 4 4.7 CN(C(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(CO)Cc1ccccc1 10.1021/jm00086a017
CHEMBL422941 172024 0 None - 0 Mouse 6.0 pIC50 = 6.0 Binding
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 529 9 3 4 4.7 CN(C(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(CO)Cc1ccccc1 10.1021/jm00086a017
44283514 177396 0 None - 0 Mouse 6.0 pIC50 = 6.0 Binding
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 585 12 3 4 6.0 CC(Cc1c[nH]c2ccccc12)(CN(CCc1ccccc1)C(=O)CCC(=O)O)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
CHEMBL445094 177396 0 None - 0 Mouse 6.0 pIC50 = 6.0 Binding
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 585 12 3 4 6.0 CC(Cc1c[nH]c2ccccc12)(CN(CCc1ccccc1)C(=O)CCC(=O)O)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
10738855 213390 0 None - 0 Mouse 6.0 pIC50 = 6.0 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 385 4 3 5 3.8 Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2ccccc2)c1 10.1021/jm970373j
CHEMBL8905 213390 0 None - 0 Mouse 6.0 pIC50 = 6.0 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 385 4 3 5 3.8 Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2ccccc2)c1 10.1021/jm970373j
44382038 127238 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 420 4 2 3 3.1 Cc1cccc(NC(=O)N[C@@H]2CCc3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 10.1016/S0960-894X(00)80683-6
CHEMBL354040 127238 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 420 4 2 3 3.1 Cc1cccc(NC(=O)N[C@@H]2CCc3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 10.1016/S0960-894X(00)80683-6
443375 214385 45 None -389 5 Rat 6.0 pIC50 = 6.0 Binding
Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1016/0960-894X(96)00160-6
CHEMBL9506 214385 45 None -389 5 Rat 6.0 pIC50 = 6.0 Binding
Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1016/0960-894X(96)00160-6
CHEMBL408083 219477 0 None -3 4 Human 6.0 pIC50 = 6.0 Binding
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](CCCC)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
16100406 89999 0 None -281 4 Human 6.0 pIC50 = 6.0 Binding
Displacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1132 28 13 13 1.7 CCCC[C@@H](NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1cc2ccccc2[nH]1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061268p
CHEMBL218600 89999 0 None -281 4 Human 6.0 pIC50 = 6.0 Binding
Displacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1132 28 13 13 1.7 CCCC[C@@H](NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1cc2ccccc2[nH]1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061268p
10551234 103716 0 None - 0 Mouse 8.0 pIC50 = 8.0 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 443 6 3 6 4.6 Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(OC(C)C)c2)c1 10.1021/jm970373j
CHEMBL266120 103716 0 None - 0 Mouse 8.0 pIC50 = 8.0 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 443 6 3 6 4.6 Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(OC(C)C)c2)c1 10.1021/jm970373j
10455303 121998 8 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 429 4 2 5 3.6 CN1C(=O)C(NC(=O)Nc2cccc([N+](=O)[O-])c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL334592 121998 8 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 429 4 2 5 3.6 CN1C(=O)C(NC(=O)Nc2cccc([N+](=O)[O-])c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
10005779 123442 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 489 6 3 4 3.8 CCNC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL337065 123442 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 489 6 3 4 3.8 CCNC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
44280996 106520 0 None - 1 Human 8.0 pIC50 = 8.0 Binding
Inhibitory activity against gastrin receptor.Inhibitory activity against gastrin receptor.
ChEMBL 745 14 4 8 5.4 CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
CHEMBL284976 106520 0 None - 1 Human 8.0 pIC50 = 8.0 Binding
Inhibitory activity against gastrin receptor.Inhibitory activity against gastrin receptor.
ChEMBL 745 14 4 8 5.4 CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
11555184 172811 0 None - 3 Dog 8.0 pIC50 = 8.0 Binding
Concentration required to inhibit the binding of [125I]-BH-CCK-8S radioligand to canine gastric mucosa CCK2 receptorConcentration required to inhibit the binding of [125I]-BH-CCK-8S radioligand to canine gastric mucosa CCK2 receptor
ChEMBL 503 7 3 3 7.0 Cc1ccc(NC(=O)c2[nH]c(C3(C)CCCCC3)nc2CCC23CC4CC(CC(C4)C2)C3)cc1C(=O)O 10.1021/jm0490686
CHEMBL425574 172811 0 None - 3 Dog 8.0 pIC50 = 8.0 Binding
Concentration required to inhibit the binding of [125I]-BH-CCK-8S radioligand to canine gastric mucosa CCK2 receptorConcentration required to inhibit the binding of [125I]-BH-CCK-8S radioligand to canine gastric mucosa CCK2 receptor
ChEMBL 503 7 3 3 7.0 Cc1ccc(NC(=O)c2[nH]c(C3(C)CCCCC3)nc2CCC23CC4CC(CC(C4)C2)C3)cc1C(=O)O 10.1021/jm0490686
145990693 173752 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
Displacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting methodDisplacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting method
ChEMBL 465 6 3 6 4.8 CCOc1ccc(-n2c(NNC(=S)Nc3ccc(Cl)cc3)nc3ccccc3c2=O)cc1 10.1039/C7MD00171A
CHEMBL4287572 173752 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
Displacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting methodDisplacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting method
ChEMBL 465 6 3 6 4.8 CCOc1ccc(-n2c(NNC(=S)Nc3ccc(Cl)cc3)nc3ccccc3c2=O)cc1 10.1039/C7MD00171A
44333305 11823 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortexDisplacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortex
ChEMBL 502 4 2 5 3.6 CCCN1C(=O)C(NC(=O)Nc2cccc(C(F)(F)F)c2)N=C(N2CCN(C)CC2)c2ccccc21 10.1016/0960-894X(95)00530-0
CHEMBL105273 11823 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortexDisplacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortex
ChEMBL 502 4 2 5 3.6 CCCN1C(=O)C(NC(=O)Nc2cccc(C(F)(F)F)c2)N=C(N2CCN(C)CC2)c2ccccc21 10.1016/0960-894X(95)00530-0
44210424 125996 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 423 4 2 4 3.8 Cc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)OC(C)(C)C)C2=O)c1 10.1016/S0960-894X(00)80683-6
CHEMBL34335 125996 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 423 4 2 4 3.8 Cc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)OC(C)(C)C)C2=O)c1 10.1016/S0960-894X(00)80683-6
73351320 112923 0 None - 0 Mouse 7.0 pIC50 = 7.0 Binding
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 681 12 5 5 5.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCNC(=O)C(F)(F)F)c1ccccc1 10.1021/jm00092a007
CHEMBL313559 112923 0 None - 0 Mouse 7.0 pIC50 = 7.0 Binding
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 681 12 5 5 5.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCNC(=O)C(F)(F)F)c1ccccc1 10.1021/jm00092a007
14843036 106937 0 None - 0 Mouse 7.0 pIC50 = 7.0 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 413 5 1 4 4.8 COc1cccc(-n2c(CCc3c[nH]c4ccc(F)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
CHEMBL287914 106937 0 None - 0 Mouse 7.0 pIC50 = 7.0 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 413 5 1 4 4.8 COc1cccc(-n2c(CCc3c[nH]c4ccc(F)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
14843048 124023 0 None - 0 Mouse 7.0 pIC50 = 7.0 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 501 6 1 4 6.2 CC(C)Oc1ccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)cc1 10.1021/jm00108a040
CHEMBL33948 124023 0 None - 0 Mouse 7.0 pIC50 = 7.0 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 501 6 1 4 6.2 CC(C)Oc1ccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)cc1 10.1021/jm00108a040
44210424 125996 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibitory activity against Cholecystokinin type B receptor in guinea pig cerebral cortex using [125 I ]- CCK-8 as radioligand.Inhibitory activity against Cholecystokinin type B receptor in guinea pig cerebral cortex using [125 I ]- CCK-8 as radioligand.
ChEMBL 423 4 2 4 3.8 Cc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)OC(C)(C)C)C2=O)c1 10.1016/0960-894X(95)00234-K
CHEMBL34335 125996 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibitory activity against Cholecystokinin type B receptor in guinea pig cerebral cortex using [125 I ]- CCK-8 as radioligand.Inhibitory activity against Cholecystokinin type B receptor in guinea pig cerebral cortex using [125 I ]- CCK-8 as radioligand.
ChEMBL 423 4 2 4 3.8 Cc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)OC(C)(C)C)C2=O)c1 10.1016/0960-894X(95)00234-K
44279809 105743 0 None - 1 Human 7.0 pIC50 = 7.0 Binding
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 785 18 4 7 6.4 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
CHEMBL279778 105743 0 None - 1 Human 7.0 pIC50 = 7.0 Binding
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 785 18 4 7 6.4 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
CHEMBL319814 218002 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Binding affinity towards cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity towards cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL None None None CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
15689734 113386 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Displacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL 854 21 9 9 3.5 CC(=O)c1cccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c1 10.1021/jm960509y
CHEMBL3142899 113386 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Displacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL 854 21 9 9 3.5 CC(=O)c1cccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c1 10.1021/jm960509y
CHEMBL319814 218002 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Displacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL None None None CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00173a006
44381201 168455 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
In vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic aciniIn vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic acini
ChEMBL 1062 29 9 12 3.6 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)CCc1ccccc1 10.1016/S0960-894X(00)80679-4
CHEMBL413186 168455 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
In vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic aciniIn vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic acini
ChEMBL 1062 29 9 12 3.6 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)CCc1ccccc1 10.1016/S0960-894X(00)80679-4
14843041 131820 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of [125I]-labeled gastrin binding to gastrin/cholecystokinin type B receptorInhibition of [125I]-labeled gastrin binding to gastrin/cholecystokinin type B receptor
ChEMBL 471 5 1 3 6.0 CCc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
CHEMBL36436 131820 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of [125I]-labeled gastrin binding to gastrin/cholecystokinin type B receptorInhibition of [125I]-labeled gastrin binding to gastrin/cholecystokinin type B receptor
ChEMBL 471 5 1 3 6.0 CCc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
73354298 103446 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat TcellsInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat Tcells
ChEMBL 1017 29 9 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCCc1ccccc1)CC(=O)O 10.1021/jm00072a024
CHEMBL263876 103446 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat TcellsInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat Tcells
ChEMBL 1017 29 9 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCCc1ccccc1)CC(=O)O 10.1021/jm00072a024
10031700 18962 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 486 7 2 4 3.7 COc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC[N+](C)(C)C)C2=O)c1 10.1021/jm00078a018
CHEMBL1184246 18962 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 486 7 2 4 3.7 COc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC[N+](C)(C)C)C2=O)c1 10.1021/jm00078a018
CHEMBL340975 18962 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 486 7 2 4 3.7 COc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC[N+](C)(C)C)C2=O)c1 10.1021/jm00078a018
10070678 127533 1 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 418 3 2 3 4.3 CN1C(=O)[C@@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL355092 127533 1 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 418 3 2 3 4.3 CN1C(=O)[C@@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
44334452 11331 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 497 9 2 3 5.6 Cc1cccc(NC(=O)N[C@H](CCCc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
CHEMBL102461 11331 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 497 9 2 3 5.6 Cc1cccc(NC(=O)N[C@H](CCCc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
15689738 113380 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 862 20 9 8 4.4 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1cccc2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
CHEMBL3142705 113380 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 862 20 9 8 4.4 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1cccc2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
10320031 84600 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 421 3 1 3 4.0 CN1C(=O)[C@H](NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00121a004
CHEMBL2092868 84600 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 421 3 1 3 4.0 CN1C(=O)[C@H](NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00121a004
14208307 84599 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 513 3 1 3 4.0 CN1C(=O)[C@@H](NC(=O)c2ccccc2I)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL2092867 84599 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 513 3 1 3 4.0 CN1C(=O)[C@@H](NC(=O)c2ccccc2I)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
14208216 109480 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 393 3 1 4 3.5 CN1C(=O)C(NC(=O)c2ccsc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL304768 109480 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 393 3 1 4 3.5 CN1C(=O)C(NC(=O)c2ccsc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
14208210 210982 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 413 3 2 4 4.1 O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1cc2ccccc2o1 10.1021/jm00120a002
CHEMBL70856 210982 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 413 3 2 4 4.1 O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1cc2ccccc2o1 10.1021/jm00120a002
44375135 59532 0 None - 0 Mouse 5.0 pIC50 = 5.0 Binding
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 520 12 6 7 2.7 O=C(O)CCCNS(=O)(=O)c1ccc(N/N=C(/S)NCCc2c[nH]c3ccccc23)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
CHEMBL159469 59532 0 None - 0 Mouse 5.0 pIC50 = 5.0 Binding
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 520 12 6 7 2.7 O=C(O)CCCNS(=O)(=O)c1ccc(N/N=C(/S)NCCc2c[nH]c3ccccc23)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
15104606 16229 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 497 13 2 2 6.9 CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccc2ccccc2c1 10.1021/jm00116a002
CHEMBL111837 16229 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 497 13 2 2 6.9 CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccc2ccccc2c1 10.1021/jm00116a002
10364355 34724 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 412 4 2 3 3.9 C[C@H](NC(=O)NC1N=C(c2ccccc2)c2ccccc2N(C)C1=O)c1ccccc1 10.1021/jm00078a018
CHEMBL137208 34724 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 412 4 2 3 3.9 C[C@H](NC(=O)NC1N=C(c2ccccc2)c2ccccc2N(C)C1=O)c1ccccc1 10.1021/jm00078a018
15200522 127246 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Tested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brainTested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL 422 4 2 3 3.7 CN1C(=O)C(NC(=O)Cc2c[nH]c3ccccc23)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80682-4
CHEMBL354126 127246 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Tested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brainTested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL 422 4 2 3 3.7 CN1C(=O)C(NC(=O)Cc2c[nH]c3ccccc23)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80682-4
44382008 65824 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain at a pH of 6.5The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain at a pH of 6.5
ChEMBL 403 3 1 3 3.9 CN1C(=O)[C@H](NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80684-8
CHEMBL169438 65824 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain at a pH of 6.5The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain at a pH of 6.5
ChEMBL 403 3 1 3 3.9 CN1C(=O)[C@H](NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80684-8
44280502 106162 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 672 14 4 5 4.8 O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NCCc1ccccc1 10.1021/jm950372w
CHEMBL282639 106162 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 672 14 4 5 4.8 O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NCCc1ccccc1 10.1021/jm950372w
10253714 32266 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 460 4 2 3 5.3 CN1C(=O)C(NC(=O)Nc2cccc(-c3ccccc3)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL135060 32266 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 460 4 2 3 5.3 CN1C(=O)C(NC(=O)Nc2cccc(-c3ccccc3)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
10722103 118251 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 588 8 1 6 5.3 COc1ccc(N(C(=O)CN2C(=O)C(Cc3n[nH]c4ncccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm970265x
CHEMBL327656 118251 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 588 8 1 6 5.3 COc1ccc(N(C(=O)CN2C(=O)C(Cc3n[nH]c4ncccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm970265x
44327456 214621 0 None - 0 Mouse 7.0 pIC50 = 7.0 Binding
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 585 11 2 5 5.7 COC(=O)CCN(CCc1ccccc1)C(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1016/S0960-894X(01)80769-1
CHEMBL96401 214621 0 None - 0 Mouse 7.0 pIC50 = 7.0 Binding
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 585 11 2 5 5.7 COC(=O)CCN(CCc1ccccc1)C(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1016/S0960-894X(01)80769-1
155560670 181871 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1886 72 17 23 4.2 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4568746 181871 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1886 72 17 23 4.2 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O 10.1021/acs.jmedchem.8b01558
44279810 110621 0 None - 1 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 757 16 4 7 5.7 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
CHEMBL30917 110621 0 None - 1 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 757 16 4 7 5.7 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
73354298 103446 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranesInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranes
ChEMBL 1017 29 9 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCCc1ccccc1)CC(=O)O 10.1021/jm00072a024
CHEMBL263876 103446 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranesInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranes
ChEMBL 1017 29 9 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCCc1ccccc1)CC(=O)O 10.1021/jm00072a024
10074366 127376 0 None - 0 Mouse 5.9 pIC50 = 5.9 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 9 4 4 4.5 C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
CHEMBL3349028 127376 0 None - 0 Mouse 5.9 pIC50 = 5.9 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 9 4 4 4.5 C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
CHEMBL3545866 127376 0 None - 0 Mouse 5.9 pIC50 = 5.9 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 9 4 4 4.5 C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
44329518 215113 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 560 6 3 3 6.2 Cc1ccccc1[C@H]1C[C@@H](NC(=O)Nc2ccc(Cl)cc2)C(=O)N(CC(=O)NC(C)(C)C)[C@@H](c2ccccc2)C1 10.1016/S0960-894X(01)80832-5
CHEMBL99311 215113 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 560 6 3 3 6.2 Cc1ccccc1[C@H]1C[C@@H](NC(=O)Nc2ccc(Cl)cc2)C(=O)N(CC(=O)NC(C)(C)C)[C@@H](c2ccccc2)C1 10.1016/S0960-894X(01)80832-5
10622006 213543 0 None - 0 Mouse 5.9 pIC50 = 5.9 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 419 4 3 5 4.5 Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2ccc(Cl)cc2)c1 10.1021/jm970373j
CHEMBL9010 213543 0 None - 0 Mouse 5.9 pIC50 = 5.9 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 419 4 3 5 4.5 Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2ccc(Cl)cc2)c1 10.1021/jm970373j
44382327 66131 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 436 5 2 4 2.8 COc1cccc(NC(=O)N[C@H]2CCc3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 10.1016/S0960-894X(00)80683-6
CHEMBL170777 66131 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 436 5 2 4 2.8 COc1cccc(NC(=O)N[C@H]2CCc3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 10.1016/S0960-894X(00)80683-6
44283515 106951 0 None - 0 Mouse 5.9 pIC50 = 5.9 Binding
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 516 8 2 4 6.5 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)SCCc1ccccc1 10.1021/jm00086a017
CHEMBL288038 106951 0 None - 0 Mouse 5.9 pIC50 = 5.9 Binding
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 516 8 2 4 6.5 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)SCCc1ccccc1 10.1021/jm00086a017
44280000 110030 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 525 10 3 4 4.0 O=C(O)CCCNC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL30844 110030 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 525 10 3 4 4.0 O=C(O)CCCNC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
10319892 65865 2 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 418 3 2 3 4.3 CN1C(=O)[C@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00121a004
CHEMBL169661 65865 2 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 418 3 2 3 4.3 CN1C(=O)[C@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00121a004
CHEMBL2386884 217175 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of Eu-DTPA-CCK8 from CCK2 receptor in HEK293 cells after 2 hrs by TRF assayDisplacement of Eu-DTPA-CCK8 from CCK2 receptor in HEK293 cells after 2 hrs by TRF assay
ChEMBL None None None C#CCCC(=O)NCCCC[C@H](NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1cn(CC(=O)NCCCC(CCCNC(=O)Cn2cc(NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCC)N(C)C(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCCNC(=O)CCC#C)NC(C)=O)nn2)(NC(=O)CNC(=O)Cn2cc(NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCC)N(C)C(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCCNC(=O)CCC#C)NC(C)=O)nn2)C(=O)NCCC(N)=O)nn1 10.1016/j.bmcl.2013.02.022
10010811 113385 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL 854 21 9 9 3.5 CC(=O)c1ccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 10.1021/jm960509y
CHEMBL3142898 113385 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL 854 21 9 9 3.5 CC(=O)c1ccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 10.1021/jm960509y
73349791 212586 0 None - 0 Mouse 7.9 pIC50 = 7.9 Binding
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 664 13 5 6 5.2 CCOP(=O)(O)CC(=O)N[C@H](CNC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3)c1ccccc1 10.1021/jm00092a007
CHEMBL83244 212586 0 None - 0 Mouse 7.9 pIC50 = 7.9 Binding
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 664 13 5 6 5.2 CCOP(=O)(O)CC(=O)N[C@H](CNC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3)c1ccccc1 10.1021/jm00092a007
73348230 213141 0 None - 0 Mouse 7.9 pIC50 = 7.9 Binding
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 634 11 5 5 4.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CP(C)(=O)O)c1ccccc1 10.1021/jm00092a007
CHEMBL87470 213141 0 None - 0 Mouse 7.9 pIC50 = 7.9 Binding
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 634 11 5 5 4.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CP(C)(=O)O)c1ccccc1 10.1021/jm00092a007
73346731 88321 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
Inhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic aciniInhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic acini
ChEMBL 1017 29 9 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCCc1ccccc1)CC(=O)O 10.1021/jm00072a024
CHEMBL216079 88321 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
Inhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic aciniInhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic acini
ChEMBL 1017 29 9 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCCc1ccccc1)CC(=O)O 10.1021/jm00072a024
10647112 170202 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 447 3 3 4 4.1 Cc1cccc(NC(=O)N[C@@H]2N=C([C@H]3CCC(C)(C)CCN3)c3ccccc3N(C)C2=O)c1 10.1021/jm9608523
CHEMBL419663 170202 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 447 3 3 4 4.1 Cc1cccc(NC(=O)N[C@@H]2N=C([C@H]3CCC(C)(C)CCN3)c3ccccc3N(C)C2=O)c1 10.1021/jm9608523
9896825 109754 0 None - 1 Human 7.9 pIC50 = 7.9 Binding
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 742 14 6 10 2.9 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCC(=O)NCCSCc4csc(N=C(N)N)n4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL30656 109754 0 None - 1 Human 7.9 pIC50 = 7.9 Binding
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 742 14 6 10 2.9 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCC(=O)NCCSCc4csc(N=C(N)N)n4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
10319892 65865 2 None - 0 Human 7.9 pIC50 = 7.9 Binding
Tested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pigTested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pig
ChEMBL 418 3 2 3 4.3 CN1C(=O)[C@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80682-4
CHEMBL169661 65865 2 None - 0 Human 7.9 pIC50 = 7.9 Binding
Tested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pigTested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pig
ChEMBL 418 3 2 3 4.3 CN1C(=O)[C@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80682-4
9805700 125933 0 None - 0 Mouse 7.9 pIC50 = 7.9 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 492 6 3 4 4.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NN1CCCCCC1 10.1021/jm970065l
CHEMBL342932 125933 0 None - 0 Mouse 7.9 pIC50 = 7.9 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 492 6 3 4 4.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NN1CCCCCC1 10.1021/jm970065l
19766169 172345 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 443 4 2 4 4.2 CC(C)(C)OC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)CCc2ccccc21 10.1016/S0960-894X(00)80683-6
CHEMBL424211 172345 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 443 4 2 4 4.2 CC(C)(C)OC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)CCc2ccccc21 10.1016/S0960-894X(00)80683-6
14208237 210992 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 498 6 2 5 3.8 CCOC(=O)CN1C(=O)C(NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL70883 210992 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 498 6 2 5 3.8 CCOC(=O)CN1C(=O)C(NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
14991586 107415 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 838 21 7 9 3.0 CN(C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCNC(=O)/C=C/c1cccnc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL292071 107415 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 838 21 7 9 3.0 CN(C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCNC(=O)/C=C/c1cccnc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
44334248 11452 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 528 8 3 5 4.9 Cc1cccc(NC(=O)N[C@H](COC(=O)Nc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
CHEMBL103312 11452 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 528 8 3 5 4.9 Cc1cccc(NC(=O)N[C@H](COC(=O)Nc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
CHEMBL262767 217327 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity towards cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity towards cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL None None None Cc1ccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 10.1021/jm00113a023
44382486 66194 0 None - 0 Mouse 5.9 pIC50 = 5.9 Binding
Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)
ChEMBL 518 11 4 4 2.8 CCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N1C[C@H](Cc2ccccc2)NC(=O)[C@@H]1CC(=O)O 10.1016/S0960-894X(01)80253-5
CHEMBL171051 66194 0 None - 0 Mouse 5.9 pIC50 = 5.9 Binding
Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)
ChEMBL 518 11 4 4 2.8 CCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N1C[C@H](Cc2ccccc2)NC(=O)[C@@H]1CC(=O)O 10.1016/S0960-894X(01)80253-5
11803697 113393 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL 857 21 9 10 3.2 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1cccc([N+](=O)[O-])c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm960509y
136898911 113393 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL 857 21 9 10 3.2 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1cccc([N+](=O)[O-])c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm960509y
CHEMBL3142912 113393 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL 857 21 9 10 3.2 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1cccc([N+](=O)[O-])c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm960509y
CHEMBL262767 217327 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL None None None Cc1ccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 10.1021/jm960509y
CHEMBL262767 217327 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL None None None Cc1ccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 10.1021/jm00173a006
44311939 211274 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 530 6 2 5 4.2 CN1C(=O)C(NC(=O)[C@H](Cc2ccccc2)NC(=O)OC(C)(C)C)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL72526 211274 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 530 6 2 5 4.2 CN1C(=O)C(NC(=O)[C@H](Cc2ccccc2)NC(=O)OC(C)(C)C)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
44377790 126760 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.
ChEMBL 678 16 7 7 2.5 CC(C)C[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)C(Cc1ccccc1)C(N)=O)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00388a002
CHEMBL349888 126760 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.
ChEMBL 678 16 7 7 2.5 CC(C)C[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)C(Cc1ccccc1)C(N)=O)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00388a002
73346732 176700 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranesInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranes
ChEMBL 1017 29 9 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCCc1ccccc1)CC(=O)O 10.1021/jm00072a024
CHEMBL444113 176700 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranesInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranes
ChEMBL 1017 29 9 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCCc1ccccc1)CC(=O)O 10.1021/jm00072a024
11742520 36399 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 414 4 2 4 3.7 COc1ccccc1NC(=O)NC1N=C(c2ccccc2)c2ccccc2N(C)C1=O 10.1021/jm00078a018
CHEMBL138592 36399 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 414 4 2 4 3.7 COc1ccccc1NC(=O)NC1N=C(c2ccccc2)c2ccccc2N(C)C1=O 10.1021/jm00078a018
10094138 175109 8 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 429 4 2 5 3.6 CN1C(=O)C(NC(=O)Nc2ccccc2[N+](=O)[O-])N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL434255 175109 8 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 429 4 2 5 3.6 CN1C(=O)C(NC(=O)Nc2ccccc2[N+](=O)[O-])N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
14991569 105575 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 863 20 9 9 3.7 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1ccc2cc(O)ccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL278447 105575 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 863 20 9 9 3.7 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1ccc2cc(O)ccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
44349011 123638 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 373 8 4 3 2.7 CC(C)(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1cc2ccccc2[nH]1 10.1021/jm00079a003
CHEMBL338134 123638 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 373 8 4 3 2.7 CC(C)(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1cc2ccccc2[nH]1 10.1021/jm00079a003
44349070 171270 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 421 7 3 4 3.0 O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NN1CCC2(CCCC2)CC1 10.1021/jm00079a003
CHEMBL421438 171270 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 421 7 3 4 3.0 O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NN1CCC2(CCCC2)CC1 10.1021/jm00079a003
13822916 196505 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Displacement of [125I]gastrin from guinea pig gastric glandsDisplacement of [125I]gastrin from guinea pig gastric glands
ChEMBL 421 3 1 4 5.3 Cc1nnc2n1-c1ccccc1C(c1ccccc1F)=N[C@@H]2Cc1c[nH]c2ccccc12 10.1021/jm00396a028
CHEMBL51569 196505 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Displacement of [125I]gastrin from guinea pig gastric glandsDisplacement of [125I]gastrin from guinea pig gastric glands
ChEMBL 421 3 1 4 5.3 Cc1nnc2n1-c1ccccc1C(c1ccccc1F)=N[C@@H]2Cc1c[nH]c2ccccc12 10.1021/jm00396a028
44381202 168610 0 None - 0 Rat 4.9 pIC50 = 4.9 Binding
In vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic aciniIn vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic acini
ChEMBL 1139 31 10 12 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NC(Cc1ccccc1)Cc1ccccc1 10.1016/S0960-894X(00)80679-4
CHEMBL414523 168610 0 None - 0 Rat 4.9 pIC50 = 4.9 Binding
In vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic aciniIn vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic acini
ChEMBL 1139 31 10 12 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NC(Cc1ccccc1)Cc1ccccc1 10.1016/S0960-894X(00)80679-4
15104594 16895 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 498 13 2 3 6.3 CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cnc2ccccc2c1 10.1021/jm00116a002
CHEMBL115656 16895 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 498 13 2 3 6.3 CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cnc2ccccc2c1 10.1021/jm00116a002
11729474 11443 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortexDisplacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortex
ChEMBL 420 2 2 5 2.1 Cc1cccc(NC(=O)NC2N=C(N3CCN(C)CC3)c3ccccc3N(C)C2=O)c1 10.1016/0960-894X(95)00530-0
CHEMBL103229 11443 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortexDisplacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortex
ChEMBL 420 2 2 5 2.1 Cc1cccc(NC(=O)NC2N=C(N3CCN(C)CC3)c3ccccc3N(C)C2=O)c1 10.1016/0960-894X(95)00530-0
44396746 133838 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
Inhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenatesInhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenates
ChEMBL 637 8 2 6 5.7 C[C@H]1C(=O)N(c2ccc(N(C)C)cc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC3C4CC5CC(C4)CC3C5)C12 10.1021/jm0498755
CHEMBL365620 133838 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
Inhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenatesInhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenates
ChEMBL 637 8 2 6 5.7 C[C@H]1C(=O)N(c2ccc(N(C)C)cc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC3C4CC5CC(C4)CC3C5)C12 10.1021/jm0498755
10839347 37034 0 None - 0 Mouse 6.9 pIC50 = 6.9 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 507 7 4 4 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1(CO)CCCCC1 10.1021/jm970065l
CHEMBL139101 37034 0 None - 0 Mouse 6.9 pIC50 = 6.9 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 507 7 4 4 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1(CO)CCCCC1 10.1021/jm970065l
44280992 106895 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 678 12 4 5 5.5 CC1(C)CCC(NC(=O)[C@@H](CCC(=O)O)NC(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCC3)CC2)CC1 10.1021/jm950372w
CHEMBL287564 106895 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 678 12 4 5 5.5 CC1(C)CCC(NC(=O)[C@@H](CCC(=O)O)NC(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCC3)CC2)CC1 10.1021/jm950372w
44283081 106647 0 None - 0 Mouse 5.9 pIC50 = 5.9 Binding
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 500 9 3 3 6.4 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(O)CCCc1ccccc1 10.1021/jm00086a017
CHEMBL2112071 106647 0 None - 0 Mouse 5.9 pIC50 = 5.9 Binding
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 500 9 3 3 6.4 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(O)CCCc1ccccc1 10.1021/jm00086a017
CHEMBL285880 106647 0 None - 0 Mouse 5.9 pIC50 = 5.9 Binding
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 500 9 3 3 6.4 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(O)CCCc1ccccc1 10.1021/jm00086a017
10761732 82721 0 None - 0 Mouse 5.9 pIC50 = 5.9 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 371 4 3 5 3.5 O=C(NNc1nc2ccccc2c(=O)n1-c1ccccc1)Nc1ccccc1 10.1021/jm970373j
CHEMBL2051984 82721 0 None - 0 Mouse 5.9 pIC50 = 5.9 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 371 4 3 5 3.5 O=C(NNc1nc2ccccc2c(=O)n1-c1ccccc1)Nc1ccccc1 10.1021/jm970373j
44283246 106738 0 None - 0 Mouse 6.9 pIC50 = 6.9 Binding
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 527 8 2 4 6.8 O=C(NC(Cc1c[nH]c2ccccc12)C1CN=C(CCc2ccccc2)S1)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
CHEMBL286442 106738 0 None - 0 Mouse 6.9 pIC50 = 6.9 Binding
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 527 8 2 4 6.8 O=C(NC(Cc1c[nH]c2ccccc12)C1CN=C(CCc2ccccc2)S1)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
44303515 108870 0 None - 0 Mouse 6.9 pIC50 = 6.9 Binding
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 571 9 2 5 5.3 CN(C)C(=O)c1oc2ccccc2c1CC(C)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 10.1016/S0960-894X(97)00356-9
CHEMBL302194 108870 0 None - 0 Mouse 6.9 pIC50 = 6.9 Binding
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 571 9 2 5 5.3 CN(C)C(=O)c1oc2ccccc2c1CC(C)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 10.1016/S0960-894X(97)00356-9
49798104 17617 0 None 7 3 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cells
ChEMBL 1381 39 14 13 3.5 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCC(=O)N(c1ccccc1)C1CCN(CCc2ccccc2)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2010.05.078
CHEMBL1172244 17617 0 None 7 3 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cells
ChEMBL 1381 39 14 13 3.5 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCC(=O)N(c1ccccc1)C1CCN(CCc2ccccc2)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2010.05.078
CHEMBL1172249 215361 0 None -16 4 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H]1Cc2ccccc2CN1C(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2010.05.078
CHEMBL1172252 215363 0 None -173 4 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2010.05.078
CHEMBL1172253 215364 0 None -851 4 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2010.05.078
44283152 106630 0 None - 0 Mouse 5.9 pIC50 = 5.9 Binding
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 501 10 4 4 4.8 O=C(NC(CNC(CO)Cc1ccccc1)Cc1c[nH]c2ccccc12)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
CHEMBL285762 106630 0 None - 0 Mouse 5.9 pIC50 = 5.9 Binding
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 501 10 4 4 4.8 O=C(NC(CNC(CO)Cc1ccccc1)Cc1c[nH]c2ccccc12)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
44381892 19048 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Displacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortexDisplacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortex
ChEMBL 510 9 2 4 3.7 CN(C)CCNC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1016/S0960-894X(00)80681-2
CHEMBL1184772 19048 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Displacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortexDisplacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortex
ChEMBL 510 9 2 4 3.7 CN(C)CCNC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1016/S0960-894X(00)80681-2
CHEMBL368133 19048 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Displacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortexDisplacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortex
ChEMBL 510 9 2 4 3.7 CN(C)CCNC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1016/S0960-894X(00)80681-2
44279985 109880 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 511 8 3 4 3.6 CC(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O 10.1021/jm950372w
CHEMBL30764 109880 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 511 8 3 4 3.6 CC(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O 10.1021/jm950372w
11755707 64296 0 None - 0 Mouse 6.9 pIC50 = 6.9 Binding
Inhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 500 8 2 7 4.7 CCOC(=O)c1cccc(NC(=O)NCc2nc3ccccc3c(=O)n2-c2cccc(OC(C)C)c2)c1 10.1016/S0960-894X(97)00108-X
CHEMBL166168 64296 0 None - 0 Mouse 6.9 pIC50 = 6.9 Binding
Inhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 500 8 2 7 4.7 CCOC(=O)c1cccc(NC(=O)NCc2nc3ccccc3c(=O)n2-c2cccc(OC(C)C)c2)c1 10.1016/S0960-894X(97)00108-X
10074366 127376 0 None - 0 Mouse 5.9 pIC50 = 5.9 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 9 4 4 4.5 C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
CHEMBL3349028 127376 0 None - 0 Mouse 5.9 pIC50 = 5.9 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 9 4 4 4.5 C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
CHEMBL3545866 127376 0 None - 0 Mouse 5.9 pIC50 = 5.9 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 9 4 4 4.5 C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
44396624 130664 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Inhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenatesInhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenates
ChEMBL 559 7 2 6 4.7 C[C@H]1C(=O)N(c2ccc(N(C)C)cc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC(C)(C)C)C12 10.1021/jm0498755
CHEMBL362769 130664 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Inhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenatesInhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenates
ChEMBL 559 7 2 6 4.7 C[C@H]1C(=O)N(c2ccc(N(C)C)cc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC(C)(C)C)C12 10.1021/jm0498755
155514432 176644 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 2121 86 19 27 2.3 CCCC[C@H](NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)[C@H](CCCCN)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4440303 176644 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 2121 86 19 27 2.3 CCCC[C@H](NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)[C@H](CCCCN)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
10531430 119124 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 587 8 1 5 5.9 COc1ccccc1N(C(=O)CN1C(=O)C(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc21)C(C)C 10.1021/jm970265x
CHEMBL329407 119124 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 587 8 1 5 5.9 COc1ccccc1N(C(=O)CN1C(=O)C(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc21)C(C)C 10.1021/jm970265x
10349938 169698 0 None - 0 Mouse 6.9 pIC50 = 6.9 Binding
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 722 14 4 6 6.7 CC(Cc1c[nH]c2ccc(F)cc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)OCc1ccccc1)c1ccccc1 10.1016/S0960-894X(97)00356-9
CHEMBL417412 169698 0 None - 0 Mouse 6.9 pIC50 = 6.9 Binding
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 722 14 4 6 6.7 CC(Cc1c[nH]c2ccc(F)cc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)OCc1ccccc1)c1ccccc1 10.1016/S0960-894X(97)00356-9
44279938 169404 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 637 10 3 4 6.0 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](Cc1ccc2ccccc2c1)C(=O)O 10.1021/jm950372w
CHEMBL416944 169404 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 637 10 3 4 6.0 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](Cc1ccc2ccccc2c1)C(=O)O 10.1021/jm950372w
44386117 138129 0 None - 0 Mouse 7.9 pIC50 = 7.9 Binding
Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.
ChEMBL 541 9 4 4 5.3 O=C(O)C[C@H](Cc1ccccc1)NC(=O)/C(=C/c1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1016/S0960-894X(00)80273-5
CHEMBL368803 138129 0 None - 0 Mouse 7.9 pIC50 = 7.9 Binding
Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.
ChEMBL 541 9 4 4 5.3 O=C(O)C[C@H](Cc1ccccc1)NC(=O)/C(=C/c1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1016/S0960-894X(00)80273-5
44333048 176036 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat TcellsInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat Tcells
ChEMBL 1032 28 10 11 3.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 10.1021/jm00072a024
CHEMBL441165 176036 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat TcellsInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat Tcells
ChEMBL 1032 28 10 11 3.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 10.1021/jm00072a024
73349806 103217 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
Inhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic aciniInhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic acini
ChEMBL 1019 29 9 11 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCOc1ccccc1)CC(=O)O 10.1021/jm00072a024
CHEMBL262155 103217 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
Inhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic aciniInhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic acini
ChEMBL 1019 29 9 11 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCOc1ccccc1)CC(=O)O 10.1021/jm00072a024
44348764 175411 0 None - 0 Bovine 7.9 pIC50 = 7.9 Binding
Inhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatumInhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatum
ChEMBL 980 28 11 11 1.4 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCCNC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00099a005
CHEMBL436199 175411 0 None - 0 Bovine 7.9 pIC50 = 7.9 Binding
Inhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatumInhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatum
ChEMBL 980 28 11 11 1.4 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCCNC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00099a005
10052234 74536 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 515 5 2 4 4.3 O=C(Nc1ccc(Cl)cc1)N[C@H]1N=C(c2ccccc2)c2ccccc2N(CC(=O)N2CCCC2)C1=O 10.1021/jm00078a018
CHEMBL1907927 74536 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 515 5 2 4 4.3 O=C(Nc1ccc(Cl)cc1)N[C@H]1N=C(c2ccccc2)c2ccccc2N(CC(=O)N2CCCC2)C1=O 10.1021/jm00078a018
44368541 175395 0 None - 0 Mouse 7.9 pIC50 = 7.9 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 590 13 5 5 4.5 C[C@H]1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CNC(=O)CCC(=O)O)Cc1ccccc1 10.1021/jm00057a005
CHEMBL436065 175395 0 None - 0 Mouse 7.9 pIC50 = 7.9 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 590 13 5 5 4.5 C[C@H]1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CNC(=O)CCC(=O)O)Cc1ccccc1 10.1021/jm00057a005
73349872 95976 1 None - 0 Rat 7.9 pIC50 = 7.9 Binding
Inhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptorInhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptor
ChEMBL 616 12 5 5 5.2 CC1(C)[C@H]2CC[C@@]1(C)[C@H](OC(=O)N[C@](C)(Cc1c[nH]c3ccccc13)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1)C2 10.1016/S0960-894X(97)00107-8
CHEMBL2367718 95976 1 None - 0 Rat 7.9 pIC50 = 7.9 Binding
Inhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptorInhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptor
ChEMBL 616 12 5 5 5.2 CC1(C)[C@H]2CC[C@@]1(C)[C@H](OC(=O)N[C@](C)(Cc1c[nH]c3ccccc13)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1)C2 10.1016/S0960-894X(97)00107-8
CHEMBL2367719 95976 1 None - 0 Rat 7.9 pIC50 = 7.9 Binding
Inhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptorInhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptor
ChEMBL 616 12 5 5 5.2 CC1(C)[C@H]2CC[C@@]1(C)[C@H](OC(=O)N[C@](C)(Cc1c[nH]c3ccccc13)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1)C2 10.1016/S0960-894X(97)00107-8
10370499 43726 0 None - 1 Mouse 7.9 pIC50 = 7.9 Binding
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 557 10 4 4 5.2 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CC(=O)O)Cc1ccccc1 10.1016/S0960-894X(00)80685-X
CHEMBL145133 43726 0 None - 1 Mouse 7.9 pIC50 = 7.9 Binding
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 557 10 4 4 5.2 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CC(=O)O)Cc1ccccc1 10.1016/S0960-894X(00)80685-X
10370499 43726 0 None - 1 Mouse 7.9 pIC50 = 7.9 Binding
Inhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptorInhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptor
ChEMBL 557 10 4 4 5.2 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CC(=O)O)Cc1ccccc1 10.1016/s0960-894x(98)00677-5
CHEMBL145133 43726 0 None - 1 Mouse 7.9 pIC50 = 7.9 Binding
Inhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptorInhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptor
ChEMBL 557 10 4 4 5.2 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CC(=O)O)Cc1ccccc1 10.1016/s0960-894x(98)00677-5
10370499 92765 0 None - 0 Mouse 7.9 pIC50 = 7.9 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 557 10 4 4 5.2 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](CC(=O)O)Cc1ccccc1 10.1021/jm00057a005
CHEMBL2304064 92765 0 None - 0 Mouse 7.9 pIC50 = 7.9 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 557 10 4 4 5.2 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](CC(=O)O)Cc1ccccc1 10.1021/jm00057a005
155517868 176990 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1893 76 19 24 3.2 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4445353 176990 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1893 76 19 24 3.2 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
9887120 210905 4 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00121a004
CHEMBL70380 210905 4 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00121a004
10324540 23362 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 524 5 3 3 5.8 CC(C)(C)NC(=O)CN1C(=O)[C@@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](C2CCCCC2)c2ccccc21 10.1021/jm00048a015
CHEMBL123981 23362 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 524 5 3 3 5.8 CC(C)(C)NC(=O)CN1C(=O)[C@@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](C2CCCCC2)c2ccccc21 10.1021/jm00048a015
14843054 126742 0 None - 0 Mouse 6.9 pIC50 = 6.9 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 503 6 1 5 5.4 COc1ccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)cc1OC 10.1021/jm00108a040
CHEMBL34979 126742 0 None - 0 Mouse 6.9 pIC50 = 6.9 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 503 6 1 5 5.4 COc1ccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)cc1OC 10.1021/jm00108a040
44356972 34429 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 555 7 3 7 3.3 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)ON3CCC[C@@H]3C(=O)O)C2=O)c1 10.1021/jm00078a018
CHEMBL136990 34429 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 555 7 3 7 3.3 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)ON3CCC[C@@H]3C(=O)O)C2=O)c1 10.1021/jm00078a018
15689734 113386 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity towards cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity towards cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 854 21 9 9 3.5 CC(=O)c1cccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c1 10.1021/jm00113a023
CHEMBL3142899 113386 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity towards cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity towards cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 854 21 9 9 3.5 CC(=O)c1cccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c1 10.1021/jm00113a023
15167816 211275 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 493 6 1 5 4.0 CCOC(=O)CN1C(=O)C(NC(=O)c2ccccc2Cl)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL72546 211275 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 493 6 1 5 4.0 CCOC(=O)CN1C(=O)C(NC(=O)c2ccccc2Cl)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
44382561 175085 0 None - 0 Mouse 5.9 pIC50 = 5.9 Binding
Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 662 13 5 5 5.8 O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1)NCCc1ccc(O)cc1 10.1016/S0960-894X(00)80687-3
CHEMBL434113 175085 0 None - 0 Mouse 5.9 pIC50 = 5.9 Binding
Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 662 13 5 5 5.8 O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1)NCCc1ccc(O)cc1 10.1016/S0960-894X(00)80687-3
14843038 144986 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of [125I]-labeled gastrin binding to gastrin/cholecystokinin type B receptorInhibition of [125I]-labeled gastrin binding to gastrin/cholecystokinin type B receptor
ChEMBL 473 5 1 4 5.4 COc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
CHEMBL37699 144986 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of [125I]-labeled gastrin binding to gastrin/cholecystokinin type B receptorInhibition of [125I]-labeled gastrin binding to gastrin/cholecystokinin type B receptor
ChEMBL 473 5 1 4 5.4 COc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
CHEMBL338056 218383 0 None - 0 Bovine 5.9 pIC50 = 5.9 Binding
Inhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatumInhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatum
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00099a005
44280374 109644 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 559 8 3 4 5.4 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)Nc1cccc(C(=O)O)c1 10.1021/jm950372w
CHEMBL30575 109644 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 559 8 3 4 5.4 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)Nc1cccc(C(=O)O)c1 10.1021/jm950372w
44210428 65888 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 485 4 2 4 3.1 CN1CCN(C(=O)CN2C(=O)C(NC(=O)Nc3cccc4ccccc34)CCc3ccccc32)CC1 10.1016/S0960-894X(00)80683-6
CHEMBL169794 65888 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 485 4 2 4 3.1 CN1CCN(C(=O)CN2C(=O)C(NC(=O)Nc3cccc4ccccc34)CCc3ccccc32)CC1 10.1016/S0960-894X(00)80683-6
14208288 74457 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 349 2 1 3 3.0 CN1C(=O)[C@@H](NC(=O)C(C)(C)C)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
CHEMBL1907660 74457 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 349 2 1 3 3.0 CN1C(=O)[C@@H](NC(=O)C(C)(C)C)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
44382560 127095 0 None - 0 Mouse 4.9 pIC50 = 4.9 Binding
Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 660 14 4 4 6.5 O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1)NCCCc1ccccc1 10.1016/S0960-894X(00)80687-3
CHEMBL352817 127095 0 None - 0 Mouse 4.9 pIC50 = 4.9 Binding
Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 660 14 4 4 6.5 O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1)NCCCc1ccccc1 10.1016/S0960-894X(00)80687-3
44370473 57636 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 435 15 3 4 4.3 CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)Nc1cccc(OC)c1 10.1021/jm00164a020
CHEMBL157722 57636 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 435 15 3 4 4.3 CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)Nc1cccc(OC)c1 10.1021/jm00164a020
44283496 106950 0 None - 0 Mouse 5.9 pIC50 = 5.9 Binding
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 527 9 2 3 6.1 CC(=O)N(CCc1ccccc1)CC(C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
CHEMBL288037 106950 0 None - 0 Mouse 5.9 pIC50 = 5.9 Binding
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 527 9 2 3 6.1 CC(=O)N(CCc1ccccc1)CC(C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
44408525 176207 0 None -56 3 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1075 30 12 14 1.5 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@@H](Cc1cn(C(C)=O)c2ccccc12)C(=O)O 10.1021/jm050851n
CHEMBL442483 176207 0 None -56 3 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1075 30 12 14 1.5 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@@H](Cc1cn(C(C)=O)c2ccccc12)C(=O)O 10.1021/jm050851n
10624013 40312 0 None - 0 Mouse 6.9 pIC50 = 6.9 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 464 6 3 4 4.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NN1CCCC1 10.1021/jm970065l
CHEMBL142063 40312 0 None - 0 Mouse 6.9 pIC50 = 6.9 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 464 6 3 4 4.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NN1CCCC1 10.1021/jm970065l
10886229 85368 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Inhibition of [3H]pCCK-8 specific binding cholecystokinin type B receptor in rat cerebral cortex membranesInhibition of [3H]pCCK-8 specific binding cholecystokinin type B receptor in rat cerebral cortex membranes
ChEMBL 559 6 3 5 4.4 Cc1cccc(N2C(=O)C[C@@H]3[C@@H](NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)OC(C)(C)C)CCCN3C2=O)c1 10.1021/jm010813d
CHEMBL2112234 85368 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Inhibition of [3H]pCCK-8 specific binding cholecystokinin type B receptor in rat cerebral cortex membranesInhibition of [3H]pCCK-8 specific binding cholecystokinin type B receptor in rat cerebral cortex membranes
ChEMBL 559 6 3 5 4.4 Cc1cccc(N2C(=O)C[C@@H]3[C@@H](NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)OC(C)(C)C)CCCN3C2=O)c1 10.1021/jm010813d
44329150 119178 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 580 7 3 3 6.8 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)NC3(C)CCCCC3)C2=O)c1 10.1016/S0960-894X(01)80832-5
CHEMBL329735 119178 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 580 7 3 3 6.8 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)NC3(C)CCCCC3)C2=O)c1 10.1016/S0960-894X(01)80832-5
16100409 90009 0 None - 3 Human 4.9 pIC50 = 4.9 Binding
Displacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1031 27 13 12 0.2 CCCC[C@@H](NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](N)Cc1ccccc1)C(=O)N[C@@H](Cc1cc2ccccc2[nH]1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061268p
CHEMBL218651 90009 0 None - 3 Human 4.9 pIC50 = 4.9 Binding
Displacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1031 27 13 12 0.2 CCCC[C@@H](NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](N)Cc1ccccc1)C(=O)N[C@@H](Cc1cc2ccccc2[nH]1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061268p
44280894 120287 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 708 19 3 5 6.6 CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL33209 120287 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 708 19 3 5 6.6 CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
44280213 108395 0 None - 1 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 685 12 5 9 3.7 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCSCc4csc(N=C(N)N)n4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL29888 108395 0 None - 1 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 685 12 5 9 3.7 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCSCc4csc(N=C(N)N)n4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
44281005 123509 0 None - 1 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against gastrin receptor.Inhibitory activity against gastrin receptor.
ChEMBL 787 17 4 8 6.4 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CCOC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 10.1016/S0960-894X(96)00249-1
CHEMBL33743 123509 0 None - 1 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against gastrin receptor.Inhibitory activity against gastrin receptor.
ChEMBL 787 17 4 8 6.4 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CCOC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 10.1016/S0960-894X(96)00249-1
44280915 107055 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 676 10 3 5 5.2 O=C(O)C[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL289008 107055 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 676 10 3 5 5.2 O=C(O)C[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
44280205 19840 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 695 12 4 6 5.6 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2ncccc12 10.1021/jm950372w
CHEMBL1190133 19840 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 695 12 4 6 5.6 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2ncccc12 10.1021/jm950372w
CHEMBL540261 19840 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 695 12 4 6 5.6 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2ncccc12 10.1021/jm950372w
44279811 103700 0 None - 1 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 743 15 4 7 5.3 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
CHEMBL265987 103700 0 None - 1 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 743 15 4 7 5.3 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
44403829 78227 0 None - 1 Human 6.9 pIC50 = 6.9 Binding
Inhibitory concentration against gastrin receptorInhibitory concentration against gastrin receptor
ChEMBL 743 15 4 7 5.3 CN1C(=O)[C@H](NC(=O)Nc2ccc(CC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm058225d
CHEMBL196143 78227 0 None - 1 Human 6.9 pIC50 = 6.9 Binding
Inhibitory concentration against gastrin receptorInhibitory concentration against gastrin receptor
ChEMBL 743 15 4 7 5.3 CN1C(=O)[C@H](NC(=O)Nc2ccc(CC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm058225d
10453063 113768 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.
ChEMBL 391 2 2 4 3.0 Cc1cccc(NC(=O)NC2N=C(N3CCCC3)c3ccccc3N(C)C2=O)c1 10.1021/jm00032a002
CHEMBL315214 113768 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.
ChEMBL 391 2 2 4 3.0 Cc1cccc(NC(=O)NC2N=C(N3CCCC3)c3ccccc3N(C)C2=O)c1 10.1021/jm00032a002
10673193 104920 0 None - 0 Mouse 6.9 pIC50 = 6.9 Binding
Inhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 506 6 2 5 5.3 CC(C)Oc1cccc(-n2c(CNC(=O)Nc3ccc(Br)cc3)nc3ccccc3c2=O)c1 10.1016/S0960-894X(97)00108-X
CHEMBL273693 104920 0 None - 0 Mouse 6.9 pIC50 = 6.9 Binding
Inhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 506 6 2 5 5.3 CC(C)Oc1cccc(-n2c(CNC(=O)Nc3ccc(Br)cc3)nc3ccccc3c2=O)c1 10.1016/S0960-894X(97)00108-X
10453063 113768 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 391 2 2 4 3.0 Cc1cccc(NC(=O)NC2N=C(N3CCCC3)c3ccccc3N(C)C2=O)c1 10.1021/jm9608523
CHEMBL315214 113768 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 391 2 2 4 3.0 Cc1cccc(NC(=O)NC2N=C(N3CCCC3)c3ccccc3N(C)C2=O)c1 10.1021/jm9608523
10671800 213522 0 None - 0 Mouse 7.9 pIC50 = 7.9 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 463 6 3 6 5.0 CC(C)Oc1cccc(-n2c(NNC(=O)Nc3ccc(Cl)cc3)nc3ccccc3c2=O)c1 10.1021/jm970373j
CHEMBL8997 213522 0 None - 0 Mouse 7.9 pIC50 = 7.9 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 463 6 3 6 5.0 CC(C)Oc1cccc(-n2c(NNC(=O)Nc3ccc(Cl)cc3)nc3ccccc3c2=O)c1 10.1021/jm970373j
10094721 213673 0 None - 0 Mouse 7.9 pIC50 = 7.9 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 439 5 3 7 3.5 CN(C)c1cccc(-n2c(NNC(=O)Nc3cccc(C#N)c3)nc3ccccc3c2=O)c1 10.1021/jm970373j
CHEMBL9083 213673 0 None - 0 Mouse 7.9 pIC50 = 7.9 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 439 5 3 7 3.5 CN(C)c1cccc(-n2c(NNC(=O)Nc3cccc(C#N)c3)nc3ccccc3c2=O)c1 10.1021/jm970373j
10649303 214235 0 None - 0 Mouse 7.9 pIC50 = 7.9 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 507 6 3 6 5.1 CC(C)Oc1cccc(-n2c(NNC(=O)Nc3ccc(Br)cc3)nc3ccccc3c2=O)c1 10.1021/jm970373j
CHEMBL9422 214235 0 None - 0 Mouse 7.9 pIC50 = 7.9 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 507 6 3 6 5.1 CC(C)Oc1cccc(-n2c(NNC(=O)Nc3ccc(Br)cc3)nc3ccccc3c2=O)c1 10.1021/jm970373j
10838356 214423 0 None - 0 Mouse 7.9 pIC50 = 7.9 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 477 6 3 7 4.4 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2ccc(Cl)cc2)c1 10.1021/jm970373j
CHEMBL9524 214423 0 None - 0 Mouse 7.9 pIC50 = 7.9 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 477 6 3 7 4.4 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2ccc(Cl)cc2)c1 10.1021/jm970373j
73349789 112914 0 None - 0 Mouse 7.9 pIC50 = 7.9 Binding
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 629 12 6 6 4.3 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCC(=O)NO)c1ccccc1 10.1021/jm00092a007
CHEMBL313499 112914 0 None - 0 Mouse 7.9 pIC50 = 7.9 Binding
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 629 12 6 6 4.3 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCC(=O)NO)c1ccccc1 10.1021/jm00092a007
14802536 164110 0 None - 0 Mouse 7.9 pIC50 = 7.9 Binding
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptor
ChEMBL 628 13 5 5 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NC[C@H](NC(=O)CCCC(=O)O)c1ccccc1 10.1021/jm00105a062
CHEMBL2112694 164110 0 None - 0 Mouse 7.9 pIC50 = 7.9 Binding
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptor
ChEMBL 628 13 5 5 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NC[C@H](NC(=O)CCCC(=O)O)c1ccccc1 10.1021/jm00105a062
CHEMBL407753 164110 0 None - 0 Mouse 7.9 pIC50 = 7.9 Binding
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptor
ChEMBL 628 13 5 5 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NC[C@H](NC(=O)CCCC(=O)O)c1ccccc1 10.1021/jm00105a062
73354298 103446 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
Inhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic aciniInhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic acini
ChEMBL 1017 29 9 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCCc1ccccc1)CC(=O)O 10.1021/jm00072a024
CHEMBL263876 103446 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
Inhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic aciniInhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic acini
ChEMBL 1017 29 9 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCCc1ccccc1)CC(=O)O 10.1021/jm00072a024
44280214 114079 0 None - 1 Human 7.9 pIC50 = 7.9 Binding
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 770 16 6 10 3.6 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCCC(=O)NCCSCc4csc(N=C(N)N)n4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL31726 114079 0 None - 1 Human 7.9 pIC50 = 7.9 Binding
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 770 16 6 10 3.6 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCCC(=O)NCCSCc4csc(N=C(N)N)n4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
15673181 92771 0 None - 0 Mouse 7.9 pIC50 = 7.9 Binding
The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the mouse cerebral cortex (CCK-B);value ranges from 8.6 to 32The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the mouse cerebral cortex (CCK-B);value ranges from 8.6 to 32
ChEMBL 629 12 6 6 4.3 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)NO)c1ccccc1 10.1016/S0960-894X(00)80652-6
CHEMBL2304156 92771 0 None - 0 Mouse 7.9 pIC50 = 7.9 Binding
The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the mouse cerebral cortex (CCK-B);value ranges from 8.6 to 32The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the mouse cerebral cortex (CCK-B);value ranges from 8.6 to 32
ChEMBL 629 12 6 6 4.3 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)NO)c1ccccc1 10.1016/S0960-894X(00)80652-6
9827037 85604 8 None - 0 Mouse 7.9 pIC50 = 7.9 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 493 6 4 4 4.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H]1CCCC[C@@H]1O 10.1021/jm970065l
CHEMBL2112795 85604 8 None - 0 Mouse 7.9 pIC50 = 7.9 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 493 6 4 4 4.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H]1CCCC[C@@H]1O 10.1021/jm970065l
9978327 85591 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 400 3 3 4 3.4 CN1C(=O)[C@H](NC(=O)Nc2cccc(O)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL2112753 85591 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 400 3 3 4 3.4 CN1C(=O)[C@H](NC(=O)Nc2cccc(O)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
44381641 175420 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Inhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptorInhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptor
ChEMBL 723 20 7 8 3.2 CCCC[C@H](N[C@H](C#N)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(97)00107-8
CHEMBL436253 175420 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Inhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptorInhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptor
ChEMBL 723 20 7 8 3.2 CCCC[C@H](N[C@H](C#N)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(97)00107-8
10673193 104920 0 None - 0 Mouse 6.9 pIC50 = 6.9 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 506 6 2 5 5.3 CC(C)Oc1cccc(-n2c(CNC(=O)Nc3ccc(Br)cc3)nc3ccccc3c2=O)c1 10.1021/jm970373j
CHEMBL273693 104920 0 None - 0 Mouse 6.9 pIC50 = 6.9 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 506 6 2 5 5.3 CC(C)Oc1cccc(-n2c(CNC(=O)Nc3ccc(Br)cc3)nc3ccccc3c2=O)c1 10.1021/jm970373j
44373702 126704 0 None - 0 Mouse 6.9 pIC50 = 6.9 Binding
Compound was tested for the inhibition of specific binding of [125I]bolton Hunter CCK-8 to Cholecystokinin type B receptor in mouse cerebral cortexCompound was tested for the inhibition of specific binding of [125I]bolton Hunter CCK-8 to Cholecystokinin type B receptor in mouse cerebral cortex
ChEMBL 555 8 4 4 5.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@]1(C(=O)O)C[C@H]1c1ccccc1 10.1016/S0960-894X(01)81250-6
CHEMBL349473 126704 0 None - 0 Mouse 6.9 pIC50 = 6.9 Binding
Compound was tested for the inhibition of specific binding of [125I]bolton Hunter CCK-8 to Cholecystokinin type B receptor in mouse cerebral cortexCompound was tested for the inhibition of specific binding of [125I]bolton Hunter CCK-8 to Cholecystokinin type B receptor in mouse cerebral cortex
ChEMBL 555 8 4 4 5.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@]1(C(=O)O)C[C@H]1c1ccccc1 10.1016/S0960-894X(01)81250-6
CHEMBL2310857 216268 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL None None None CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N1CC(OS(=O)(=O)O)C[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
44368382 52113 0 None - 0 Mouse 6.9 pIC50 = 6.9 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 511 9 4 4 4.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1CCCCC1Cl)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
CHEMBL152682 52113 0 None - 0 Mouse 6.9 pIC50 = 6.9 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 511 9 4 4 4.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1CCCCC1Cl)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
44280111 106745 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 684 11 3 5 5.0 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCc2ccccc2C1 10.1021/jm950372w
CHEMBL286510 106745 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 684 11 3 5 5.0 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCc2ccccc2C1 10.1021/jm950372w
15689729 113374 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 890 20 9 8 4.0 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1Br)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
CHEMBL3142695 113374 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 890 20 9 8 4.0 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1Br)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
CHEMBL320868 218008 0 None - 2 Human 5.9 pIC50 = 5.9 Binding
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL None None None Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
15689733 113391 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity towards cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity towards cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 870 21 9 10 3.0 COC(=O)c1cccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c1 10.1021/jm00113a023
CHEMBL3142905 113391 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity towards cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity towards cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 870 21 9 10 3.0 COC(=O)c1cccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c1 10.1021/jm00113a023
CHEMBL3142923 217916 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL None None None COc1cccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c1 10.1021/jm960509y
CHEMBL320868 218008 0 None - 2 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL None None None Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm960509y
44381695 127616 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptorDisplacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptor
ChEMBL 811 20 8 8 4.3 Cc1ccccc1NC(=O)NCCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1016/S0960-894X(00)80680-0
CHEMBL355836 127616 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptorDisplacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptor
ChEMBL 811 20 8 8 4.3 Cc1ccccc1NC(=O)NCCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1016/S0960-894X(00)80680-0
65987 106353 13 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortexDisplacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortex
ChEMBL 440 6 2 3 4.1 O=C(O)CC[C@@H](NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1016/S0960-894X(00)80681-2
CHEMBL283820 106353 13 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortexDisplacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortex
ChEMBL 440 6 2 3 4.1 O=C(O)CC[C@@H](NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1016/S0960-894X(00)80681-2
136026477 212827 0 None - 0 Mouse 5.9 pIC50 = 5.9 Binding
Evaluated for inhibition of [125I]CCK-8S binding to cholecystokinin CCK-B receptor from mouse brain membranes at a concentration of 10 uM (in vitro)Evaluated for inhibition of [125I]CCK-8S binding to cholecystokinin CCK-B receptor from mouse brain membranes at a concentration of 10 uM (in vitro)
ChEMBL 499 5 1 4 6.6 CC(C)Oc1cccc(-n2c(/C=C/c3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00092a003
CHEMBL85250 212827 0 None - 0 Mouse 5.9 pIC50 = 5.9 Binding
Evaluated for inhibition of [125I]CCK-8S binding to cholecystokinin CCK-B receptor from mouse brain membranes at a concentration of 10 uM (in vitro)Evaluated for inhibition of [125I]CCK-8S binding to cholecystokinin CCK-B receptor from mouse brain membranes at a concentration of 10 uM (in vitro)
ChEMBL 499 5 1 4 6.6 CC(C)Oc1cccc(-n2c(/C=C/c3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00092a003
14208194 170215 2 None - 2 Human 5.9 pIC50 = 5.9 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
CHEMBL419764 170215 2 None - 2 Human 5.9 pIC50 = 5.9 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
CHEMBL320868 218008 0 None - 2 Human 5.9 pIC50 = 5.9 Binding
In vitro ability to inhibit [125I]Bolton-Hunter-CCK-8 binding to Cholecystokinin type B receptor in guinea pig cortexIn vitro ability to inhibit [125I]Bolton-Hunter-CCK-8 binding to Cholecystokinin type B receptor in guinea pig cortex
ChEMBL None None None Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00031a013
73345199 148523 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat TcellsInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat Tcells
ChEMBL 1019 29 9 11 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCOc1ccccc1)CC(=O)O 10.1021/jm00072a024
CHEMBL385918 148523 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat TcellsInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat Tcells
ChEMBL 1019 29 9 11 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCOc1ccccc1)CC(=O)O 10.1021/jm00072a024
65987 106353 13 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 440 6 2 3 4.1 O=C(O)CC[C@@H](NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL283820 106353 13 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 440 6 2 3 4.1 O=C(O)CC[C@@H](NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
14991571 209715 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 905 21 8 10 3.9 CC(=O)Oc1ccc2cc(C(=O)NCCCC[C@H](NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc3ccccc3)C(N)=O)ccc2c1 10.1021/jm00089a010
CHEMBL62887 209715 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 905 21 8 10 3.9 CC(=O)Oc1ccc2cc(C(=O)NCCCC[C@H](NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc3ccccc3)C(N)=O)ccc2c1 10.1021/jm00089a010
14208214 172027 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 405 3 2 3 4.4 O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccc2ccccc2c1 10.1021/jm00120a002
CHEMBL422951 172027 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 405 3 2 3 4.4 O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccc2ccccc2c1 10.1021/jm00120a002
14208204 211244 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 407 3 2 3 4.0 O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccc(Cl)cc1 10.1021/jm00120a002
CHEMBL72300 211244 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 407 3 2 3 4.0 O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccc(Cl)cc1 10.1021/jm00120a002
44209151 66208 1 None - 0 Human 4.9 pIC50 = 4.9 Binding
Tested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pigTested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pig
ChEMBL 301 3 2 2 3.8 O=C(Cc1ccccc1)Nc1cc2c3ccccc3nc-2c[nH]1 10.1016/S0960-894X(00)80682-4
CHEMBL171108 66208 1 None - 0 Human 4.9 pIC50 = 4.9 Binding
Tested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pigTested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pig
ChEMBL 301 3 2 2 3.8 O=C(Cc1ccccc1)Nc1cc2c3ccccc3nc-2c[nH]1 10.1016/S0960-894X(00)80682-4
44303299 208030 0 None - 0 Mouse 6.9 pIC50 = 6.9 Binding
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 598 11 4 6 5.5 CC(Cc1ccc(Oc2ccccc2)cc1)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CO)[C@H](O)c1ccccc1 10.1016/S0960-894X(97)00356-9
CHEMBL60386 208030 0 None - 0 Mouse 6.9 pIC50 = 6.9 Binding
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 598 11 4 6 5.5 CC(Cc1ccc(Oc2ccccc2)cc1)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CO)[C@H](O)c1ccccc1 10.1016/S0960-894X(97)00356-9
44279937 111639 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 690 11 3 5 5.6 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL31101 111639 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 690 11 3 5 5.6 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
44329330 113964 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 540 6 3 3 5.9 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)C[C@H](c3cccc(C)c3)N(CC(=O)NC(C)(C)C)C2=O)c1 10.1016/S0960-894X(01)80832-5
CHEMBL316504 113964 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 540 6 3 3 5.9 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)C[C@H](c3cccc(C)c3)N(CC(=O)NC(C)(C)C)C2=O)c1 10.1016/S0960-894X(01)80832-5
52949124 7663 4 None 2 2 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
9055 7663 4 None 2 2 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
CHEMBL1269258 7663 4 None 2 2 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
DB12694 7663 4 None 2 2 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
44280368 103672 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 573 8 2 4 5.4 CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)c1ccc(C(=O)O)cc1 10.1021/jm950372w
CHEMBL265740 103672 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 573 8 2 4 5.4 CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)c1ccc(C(=O)O)cc1 10.1021/jm950372w
11742839 19596 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.
ChEMBL 419 2 2 4 3.7 Cc1cccc(NC(=O)N[C@H]2N=C(N3CCCCCC3)c3ccccc3N(C)C2=O)c1 10.1021/jm00032a002
CHEMBL1188361 19596 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.
ChEMBL 419 2 2 4 3.7 Cc1cccc(NC(=O)N[C@H]2N=C(N3CCCCCC3)c3ccccc3N(C)C2=O)c1 10.1021/jm00032a002
CHEMBL536245 19596 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.
ChEMBL 419 2 2 4 3.7 Cc1cccc(NC(=O)N[C@H]2N=C(N3CCCCCC3)c3ccccc3N(C)C2=O)c1 10.1021/jm00032a002
44280397 110453 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 587 10 3 4 4.9 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](Cc1ccccc1)C(=O)O 10.1021/jm950372w
CHEMBL30875 110453 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 587 10 3 4 4.9 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](Cc1ccccc1)C(=O)O 10.1021/jm950372w
CHEMBL262172 217307 0 None -691 4 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm050921q
14888709 84025 0 None - 0 Bovine 6.8 pIC50 = 6.8 Binding
Inhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranesInhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranes
ChEMBL 1031 30 11 12 0.3 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@@H](Cc1ccc(CC(=O)O)cc1)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00107a037
CHEMBL2079603 84025 0 None - 0 Bovine 6.8 pIC50 = 6.8 Binding
Inhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranesInhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranes
ChEMBL 1031 30 11 12 0.3 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@@H](Cc1ccc(CC(=O)O)cc1)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00107a037
44280103 174737 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 573 8 2 4 5.4 CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)c1ccccc1C(=O)O 10.1021/jm950372w
CHEMBL431692 174737 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 573 8 2 4 5.4 CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)c1ccccc1C(=O)O 10.1021/jm950372w
44331954 11224 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL 508 12 2 3 4.8 CCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N(CCC1CCCCC1)CC(=O)N1CCCC1 10.1016/S0960-894X(96)00546-X
CHEMBL101681 11224 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL 508 12 2 3 4.8 CCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N(CCC1CCCCC1)CC(=O)N1CCCC1 10.1016/S0960-894X(96)00546-X
44368567 175514 0 None - 0 Mouse 6.8 pIC50 = 6.8 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 495 9 4 4 4.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1CCCCC1F)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
CHEMBL437039 175514 0 None - 0 Mouse 6.8 pIC50 = 6.8 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 495 9 4 4 4.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1CCCCC1F)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
10574611 214030 0 None - 0 Mouse 7.8 pIC50 = 7.8 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 429 6 3 6 4.3 CC(C)Oc1cccc(-n2c(NNC(=O)Nc3ccccc3)nc3ccccc3c2=O)c1 10.1021/jm970373j
CHEMBL9291 214030 0 None - 0 Mouse 7.8 pIC50 = 7.8 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 429 6 3 6 4.3 CC(C)Oc1cccc(-n2c(NNC(=O)Nc3ccccc3)nc3ccccc3c2=O)c1 10.1021/jm970373j
10838217 214113 0 None - 0 Mouse 7.8 pIC50 = 7.8 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 473 7 3 8 3.7 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(OC)c2)c1 10.1021/jm970373j
CHEMBL9354 214113 0 None - 0 Mouse 7.8 pIC50 = 7.8 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 473 7 3 8 3.7 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(OC)c2)c1 10.1021/jm970373j
44330731 215023 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 946 25 9 11 0.6 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CC[C@H](NC(=O)CCc2ccc(OS(=O)(=O)O)cc2)C1=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
CHEMBL98720 215023 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 946 25 9 11 0.6 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CC[C@H](NC(=O)CCc2ccc(OS(=O)(=O)O)cc2)C1=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
73351326 89158 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Inhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic aciniInhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic acini
ChEMBL 1017 29 9 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCCc1ccccc1)CC(=O)O 10.1021/jm00072a024
CHEMBL217234 89158 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Inhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic aciniInhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic acini
ChEMBL 1017 29 9 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCCc1ccccc1)CC(=O)O 10.1021/jm00072a024
44368382 52113 0 None - 0 Mouse 7.8 pIC50 = 7.8 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 511 9 4 4 4.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1CCCCC1Cl)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
CHEMBL152682 52113 0 None - 0 Mouse 7.8 pIC50 = 7.8 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 511 9 4 4 4.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1CCCCC1Cl)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
10672231 212736 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 475 5 3 4 4.9 CCCN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C([C@H]2CCC(C)(C)CCN2)c2ccccc21 10.1021/jm9608523
CHEMBL84433 212736 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 475 5 3 4 4.9 CCCN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C([C@H]2CCC(C)(C)CCN2)c2ccccc21 10.1021/jm9608523
CHEMBL208479 215978 0 None -5 4 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](CCCC)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm050921q
CHEMBL218763 216178 0 None -15 4 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
155534993 178774 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter methodDisplacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter method
ChEMBL 1385 38 16 19 -3.1 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.9b01936
CHEMBL4471171 178774 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter methodDisplacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter method
ChEMBL 1385 38 16 19 -3.1 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.9b01936
71719689 92764 0 None - 0 Mouse 7.8 pIC50 = 7.8 Binding
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 500 8 3 4 4.8 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccn1 10.1016/S0960-894X(01)80769-1
CHEMBL2304063 92764 0 None - 0 Mouse 7.8 pIC50 = 7.8 Binding
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 500 8 3 4 4.8 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccn1 10.1016/S0960-894X(01)80769-1
155548021 180443 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter methodDisplacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter method
ChEMBL 1409 38 15 21 -2.2 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)n1cc(CNC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)nn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.9b01936
CHEMBL4534788 180443 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter methodDisplacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter method
ChEMBL 1409 38 15 21 -2.2 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)n1cc(CNC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)nn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.9b01936
10454826 106115 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibitory activity against Cholecystokinin type B receptor in guinea pig cerebral cortex using [125 I ]- CCK-8 as radioligand.Inhibitory activity against Cholecystokinin type B receptor in guinea pig cerebral cortex using [125 I ]- CCK-8 as radioligand.
ChEMBL 420 3 2 3 4.5 Cc1cccc(NC(=O)N[C@@H]2C[C@H](N3CCCCCC3)c3ccccc3N(C)C2=O)c1 10.1016/0960-894X(95)00234-K
CHEMBL282294 106115 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibitory activity against Cholecystokinin type B receptor in guinea pig cerebral cortex using [125 I ]- CCK-8 as radioligand.Inhibitory activity against Cholecystokinin type B receptor in guinea pig cerebral cortex using [125 I ]- CCK-8 as radioligand.
ChEMBL 420 3 2 3 4.5 Cc1cccc(NC(=O)N[C@@H]2C[C@H](N3CCCCCC3)c3ccccc3N(C)C2=O)c1 10.1016/0960-894X(95)00234-K
10415786 176497 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Concentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cellsConcentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL 577 7 3 5 5.0 CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccc(O)cc1 10.1021/jm950626d
CHEMBL443825 176497 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Concentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cellsConcentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL 577 7 3 5 5.0 CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccc(O)cc1 10.1021/jm950626d
44210427 127546 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 459 4 2 4 4.7 CC(C)(C)OC(=O)CN1C(=O)C(NC(=O)Nc2cccc3ccccc23)CCc2ccccc21 10.1016/S0960-894X(00)80683-6
CHEMBL355319 127546 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 459 4 2 4 4.7 CC(C)(C)OC(=O)CN1C(=O)C(NC(=O)Nc2cccc3ccccc23)CCc2ccccc21 10.1016/S0960-894X(00)80683-6
11803746 113390 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL 870 21 9 10 3.0 COC(=O)c1ccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 10.1021/jm960509y
CHEMBL3142904 113390 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL 870 21 9 10 3.0 COC(=O)c1ccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 10.1021/jm960509y
9887120 210905 4 None - 0 Mouse 6.8 pIC50 = 6.8 Binding
Half maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortexHalf maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm000937a
CHEMBL70380 210905 4 None - 0 Mouse 6.8 pIC50 = 6.8 Binding
Half maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortexHalf maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm000937a
14843030 107062 0 None - 0 Mouse 6.8 pIC50 = 6.8 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 379 4 1 3 5.0 Cc1cccc(-n2c(CCc3c[nH]c4ccccc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
CHEMBL289053 107062 0 None - 0 Mouse 6.8 pIC50 = 6.8 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 379 4 1 3 5.0 Cc1cccc(-n2c(CCc3c[nH]c4ccccc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
9887120 210905 4 None - 0 Human 6.8 pIC50 = 6.8 Binding
The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain at a pH of 6.5The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain at a pH of 6.5
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(00)80684-8
CHEMBL70380 210905 4 None - 0 Human 6.8 pIC50 = 6.8 Binding
The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain at a pH of 6.5The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain at a pH of 6.5
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(00)80684-8
CHEMBL320868 218008 0 None - 2 Human 5.8 pIC50 = 5.8 Binding
Displacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL None None None Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00173a006
14208284 74510 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 375 3 1 3 3.5 CN1C(=O)[C@H](NC(=O)C2CCCCC2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
CHEMBL1907838 74510 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 375 3 1 3 3.5 CN1C(=O)[C@H](NC(=O)C2CCCCC2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
14444021 113452 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
In vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 692 17 7 7 2.7 CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(=O)O)CC(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00123a003
CHEMBL3143386 113452 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
In vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 692 17 7 7 2.7 CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(=O)O)CC(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00123a003
73346732 176700 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat TcellsInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat Tcells
ChEMBL 1017 29 9 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCCc1ccccc1)CC(=O)O 10.1021/jm00072a024
CHEMBL444113 176700 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat TcellsInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat Tcells
ChEMBL 1017 29 9 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCCc1ccccc1)CC(=O)O 10.1021/jm00072a024
44283159 106910 0 None - 0 Mouse 5.8 pIC50 = 5.8 Binding
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 515 8 3 3 6.6 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)/C(S)=N/CCc1ccccc1 10.1021/jm00086a017
CHEMBL287682 106910 0 None - 0 Mouse 5.8 pIC50 = 5.8 Binding
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 515 8 3 3 6.6 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)/C(S)=N/CCc1ccccc1 10.1021/jm00086a017
44362746 125769 0 None - 0 Mouse 5.8 pIC50 = 5.8 Binding
Inhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptorInhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptor
ChEMBL 680 12 3 6 5.7 C[Si](C)(C)CCOC(=O)C[C@@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@H]2C[C@H](NC(=O)OCc3ccccc3)C(=O)N12 10.1016/s0960-894x(98)00677-5
CHEMBL342520 125769 0 None - 0 Mouse 5.8 pIC50 = 5.8 Binding
Inhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptorInhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptor
ChEMBL 680 12 3 6 5.7 C[Si](C)(C)CCOC(=O)C[C@@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@H]2C[C@H](NC(=O)OCc3ccccc3)C(=O)N12 10.1016/s0960-894x(98)00677-5
90663994 113600 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 837 21 8 8 3.6 Cc1ccc(/C=C\C(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 10.1021/jm00089a010
CHEMBL3144563 113600 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 837 21 8 8 3.6 Cc1ccc(/C=C\C(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 10.1021/jm00089a010
44334224 11827 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 480 7 2 5 3.3 Cc1cccc(NC(=O)N[C@H](COC(=O)N(C)C)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
CHEMBL105303 11827 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 480 7 2 5 3.3 Cc1cccc(NC(=O)N[C@H](COC(=O)N(C)C)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
CHEMBL3142685 217907 0 None - 0 Human 4.8 pIC50 = 4.8 Binding
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL None None None Cc1ccccc1NC(=O)NCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
44366345 126263 0 None - 0 Mouse 4.8 pIC50 = 4.8 Binding
Binding affinity towards CCK-B receptor in mouse cerebral cortex using [125I]Bolton-Hunter CCK-8 as radioligand; Value ranges from 9.8-25 uMBinding affinity towards CCK-B receptor in mouse cerebral cortex using [125I]Bolton-Hunter CCK-8 as radioligand; Value ranges from 9.8-25 uM
ChEMBL 447 6 2 2 5.8 O=C1[C@@H](Cc2c[nH]c3ccccc23)CN(Cc2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/0960-894X(94)80030-8
CHEMBL345327 126263 0 None - 0 Mouse 4.8 pIC50 = 4.8 Binding
Binding affinity towards CCK-B receptor in mouse cerebral cortex using [125I]Bolton-Hunter CCK-8 as radioligand; Value ranges from 9.8-25 uMBinding affinity towards CCK-B receptor in mouse cerebral cortex using [125I]Bolton-Hunter CCK-8 as radioligand; Value ranges from 9.8-25 uM
ChEMBL 447 6 2 2 5.8 O=C1[C@@H](Cc2c[nH]c3ccccc23)CN(Cc2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/0960-894X(94)80030-8
CHEMBL355608 218518 0 None - 0 Mouse 4.8 pIC50 = 4.8 Binding
Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1)C(=O)N1CC(=O)N[C@H](Cc2ccccc2)C1 10.1016/S0960-894X(01)80253-5
CHEMBL436451 220460 0 None - 0 Mouse 4.8 pIC50 = 4.8 Binding
Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N1C[C@H](Cc2ccccc2)NC(=O)[C@@H]1CC(=O)O 10.1016/S0960-894X(01)80253-5
44366108 50730 0 None - 0 Human 4.8 pIC50 = 4.8 Binding
In vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 635 15 6 6 3.8 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(=O)O)CC(=O)NCc1ccccc1 10.1021/jm00123a003
CHEMBL151276 50730 0 None - 0 Human 4.8 pIC50 = 4.8 Binding
In vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 635 15 6 6 3.8 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(=O)O)CC(=O)NCc1ccccc1 10.1021/jm00123a003
44377588 126923 0 None - 0 Human 4.8 pIC50 = 4.8 Binding
In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.
ChEMBL 636 15 7 6 3.7 CCCC[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)NCc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00388a002
CHEMBL351313 126923 0 None - 0 Human 4.8 pIC50 = 4.8 Binding
In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.
ChEMBL 636 15 7 6 3.7 CCCC[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)NCc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00388a002
14208231 211025 0 None - 0 Human 4.8 pIC50 = 4.8 Binding
Tested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brainTested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL 422 3 1 4 3.7 CN1C(=O)C(NC(=O)c2cc3ccccc3n2C)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80682-4
CHEMBL71079 211025 0 None - 0 Human 4.8 pIC50 = 4.8 Binding
Tested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brainTested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL 422 3 1 4 3.7 CN1C(=O)C(NC(=O)c2cc3ccccc3n2C)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80682-4
9887120 210905 4 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00121a004
CHEMBL70380 210905 4 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00121a004
9887120 210905 4 None - 0 Human 6.8 pIC50 = 6.8 Binding
Half maximal inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cerebral cortex.Half maximal inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cerebral cortex.
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm970517u
CHEMBL70380 210905 4 None - 0 Human 6.8 pIC50 = 6.8 Binding
Half maximal inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cerebral cortex.Half maximal inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cerebral cortex.
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm970517u
10551230 214088 0 None - 0 Mouse 6.8 pIC50 = 6.8 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 443 6 3 7 3.7 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2ccccc2)c1 10.1021/jm970373j
CHEMBL9336 214088 0 None - 0 Mouse 6.8 pIC50 = 6.8 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 443 6 3 7 3.7 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2ccccc2)c1 10.1021/jm970373j
44303237 107584 0 None - 0 Mouse 5.8 pIC50 = 5.8 Binding
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 590 10 4 8 4.3 CC(Cc1ccc(-c2csnn2)cc1)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CO)[C@H](O)c1ccccc1 10.1016/S0960-894X(97)00356-9
CHEMBL293178 107584 0 None - 0 Mouse 5.8 pIC50 = 5.8 Binding
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 590 10 4 8 4.3 CC(Cc1ccc(-c2csnn2)cc1)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CO)[C@H](O)c1ccccc1 10.1016/S0960-894X(97)00356-9
44408526 143723 0 None -1862 4 Human 5.8 pIC50 = 5.8 Binding
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1148 30 11 15 3.0 CCCC[C@@H](C(=O)N[C@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)C(=O)O)N(C)C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O 10.1021/jm050851n
CHEMBL374325 143723 0 None -1862 4 Human 5.8 pIC50 = 5.8 Binding
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1148 30 11 15 3.0 CCCC[C@@H](C(=O)N[C@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)C(=O)O)N(C)C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O 10.1021/jm050851n
44280509 106180 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 588 10 3 5 4.3 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](Cc1ccccn1)C(=O)O 10.1021/jm950372w
CHEMBL282732 106180 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 588 10 3 5 4.3 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](Cc1ccccn1)C(=O)O 10.1021/jm950372w
44280117 108828 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 672 12 3 6 5.9 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL30195 108828 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 672 12 3 6 5.9 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 10.1016/S0960-894X(96)00248-X
9802550 125954 0 None - 0 Human 4.8 pIC50 = 4.8 Binding
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 426 4 2 3 4.4 CN1c2ccccc2C(c2ccccc2F)=NCC1CNC(=O)c1cc2ccccc2[nH]1 10.1021/jm00163a069
CHEMBL343066 125954 0 None - 0 Human 4.8 pIC50 = 4.8 Binding
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 426 4 2 3 4.4 CN1c2ccccc2C(c2ccccc2F)=NCC1CNC(=O)c1cc2ccccc2[nH]1 10.1021/jm00163a069
44303652 207469 0 None - 0 Mouse 5.8 pIC50 = 5.8 Binding
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 570 8 2 3 7.2 CC(Cc1ccc2c(c1)C(C)(C)CCC2(C)C)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 10.1016/S0960-894X(97)00356-9
CHEMBL59985 207469 0 None - 0 Mouse 5.8 pIC50 = 5.8 Binding
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 570 8 2 3 7.2 CC(Cc1ccc2c(c1)C(C)(C)CCC2(C)C)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 10.1016/S0960-894X(97)00356-9
44280363 109117 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 511 8 2 4 3.6 CN(CC(=O)O)C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL30369 109117 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 511 8 2 4 3.6 CN(CC(=O)O)C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
44280176 106086 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 615 12 3 4 5.6 O=C(O)CCC(Cc1ccccc1)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL282099 106086 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 615 12 3 4 5.6 O=C(O)CCC(Cc1ccccc1)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
44280350 106628 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 658 12 3 5 4.7 CN(Cc1ccccc1)C(=O)C[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O 10.1021/jm950372w
CHEMBL285739 106628 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 658 12 3 5 4.7 CN(Cc1ccccc1)C(=O)C[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O 10.1021/jm950372w
10746778 54334 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Concentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cellsConcentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL 646 8 2 6 5.2 CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccc(N2CCOCC2)cc1 10.1021/jm950626d
CHEMBL154615 54334 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Concentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cellsConcentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL 646 8 2 6 5.2 CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccc(N2CCOCC2)cc1 10.1021/jm950626d
44365304 171531 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Tested for 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecystokinin type B receptorTested for 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecystokinin type B receptor
ChEMBL 444 8 2 3 4.3 CC(C)N(C(=O)CN(C(=O)CNC(=O)Nc1ccccc1)c1ccccc1)c1ccccc1 10.1016/S0960-894X(97)00062-0
CHEMBL421778 171531 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Tested for 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecystokinin type B receptorTested for 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecystokinin type B receptor
ChEMBL 444 8 2 3 4.3 CC(C)N(C(=O)CN(C(=O)CNC(=O)Nc1ccccc1)c1ccccc1)c1ccccc1 10.1016/S0960-894X(97)00062-0
44265901 214301 0 None - 0 Mouse 7.8 pIC50 = 7.8 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 486 5 1 4 5.5 CN(C)c1cccc(-n2c(CCc3c[nH]c4cc(Br)ccc34)nc3ccccc3c2=O)c1 10.1021/jm970373j
CHEMBL9459 214301 0 None - 0 Mouse 7.8 pIC50 = 7.8 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 486 5 1 4 5.5 CN(C)c1cccc(-n2c(CCc3c[nH]c4cc(Br)ccc34)nc3ccccc3c2=O)c1 10.1021/jm970373j
71580808 97200 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of Eu-DTPA-CCK8 from CCK2 receptor in HEK293 cells after 2 hrs by TRF assayDisplacement of Eu-DTPA-CCK8 from CCK2 receptor in HEK293 cells after 2 hrs by TRF assay
ChEMBL 842 26 8 8 1.6 C#CCCC(=O)NCCCC[C@H](NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2013.02.022
CHEMBL2386888 97200 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of Eu-DTPA-CCK8 from CCK2 receptor in HEK293 cells after 2 hrs by TRF assayDisplacement of Eu-DTPA-CCK8 from CCK2 receptor in HEK293 cells after 2 hrs by TRF assay
ChEMBL 842 26 8 8 1.6 C#CCCC(=O)NCCCC[C@H](NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2013.02.022
73349792 164193 0 None - 0 Mouse 7.8 pIC50 = 7.8 Binding
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 669 13 5 7 5.3 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCSc1nc[nH]n1)c1ccccc1 10.1021/jm00092a007
CHEMBL407857 164193 0 None - 0 Mouse 7.8 pIC50 = 7.8 Binding
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 669 13 5 7 5.3 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCSc1nc[nH]n1)c1ccccc1 10.1021/jm00092a007
44331065 114003 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 974 25 8 11 1.3 CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
CHEMBL316709 114003 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 974 25 8 11 1.3 CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
44300551 204174 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
In vitro test for inhibition of [125I]CCK binding to Cholecystokinin type B receptor from guinea pig cortical membranes was determinedIn vitro test for inhibition of [125I]CCK binding to Cholecystokinin type B receptor from guinea pig cortical membranes was determined
ChEMBL 390 3 2 3 4.1 Cc1cccc(NC(=O)NC2N=C(C3CCCC3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(01)80987-2
CHEMBL56944 204174 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
In vitro test for inhibition of [125I]CCK binding to Cholecystokinin type B receptor from guinea pig cortical membranes was determinedIn vitro test for inhibition of [125I]CCK binding to Cholecystokinin type B receptor from guinea pig cortical membranes was determined
ChEMBL 390 3 2 3 4.1 Cc1cccc(NC(=O)NC2N=C(C3CCCC3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(01)80987-2
73351327 89200 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Inhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic aciniInhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic acini
ChEMBL 1019 29 9 11 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCOc1ccccc1)CC(=O)O 10.1021/jm00072a024
CHEMBL217424 89200 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Inhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic aciniInhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic acini
ChEMBL 1019 29 9 11 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCOc1ccccc1)CC(=O)O 10.1021/jm00072a024
14843045 140329 0 None - 0 Mouse 7.8 pIC50 = 7.8 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 486 5 1 4 5.5 CN(C)c1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
CHEMBL37096 140329 0 None - 0 Mouse 7.8 pIC50 = 7.8 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 486 5 1 4 5.5 CN(C)c1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
10480792 52574 0 None - 0 Mouse 7.8 pIC50 = 7.8 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 9 4 4 4.5 CC1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
CHEMBL153095 52574 0 None - 0 Mouse 7.8 pIC50 = 7.8 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 9 4 4 4.5 CC1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
CHEMBL3350686 52574 0 None - 0 Mouse 7.8 pIC50 = 7.8 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 9 4 4 4.5 CC1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
44329456 118222 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 526 6 3 3 5.5 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)C[C@H](c3ccccc3)N(CC(=O)NC(C)(C)C)C2=O)c1 10.1016/S0960-894X(01)80832-5
CHEMBL327526 118222 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 526 6 3 3 5.5 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)C[C@H](c3ccccc3)N(CC(=O)NC(C)(C)C)C2=O)c1 10.1016/S0960-894X(01)80832-5
44280200 107601 0 None - 1 Human 7.8 pIC50 = 7.8 Binding
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 785 18 4 7 6.6 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL29331 107601 0 None - 1 Human 7.8 pIC50 = 7.8 Binding
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 785 18 4 7 6.6 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 10.1016/S0960-894X(96)00248-X
19766167 66009 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 420 4 2 3 3.1 Cc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 10.1016/S0960-894X(00)80683-6
CHEMBL170293 66009 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 420 4 2 3 3.1 Cc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 10.1016/S0960-894X(00)80683-6
71458029 85565 0 None - 0 Mouse 6.8 pIC50 = 6.8 Binding
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 628 13 5 5 5.2 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCC[C@H](NC(=O)CCC(=O)O)c1ccccc1 10.1021/jm00105a062
CHEMBL2112692 85565 0 None - 0 Mouse 6.8 pIC50 = 6.8 Binding
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 628 13 5 5 5.2 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCC[C@H](NC(=O)CCC(=O)O)c1ccccc1 10.1021/jm00105a062
4355450 142705 50 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of [125I]-labeled gastrin binding to gastrin/cholecystokinin type B receptorInhibition of [125I]-labeled gastrin binding to gastrin/cholecystokinin type B receptor
ChEMBL 501 6 1 4 6.2 CC(C)Oc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
CHEMBL37312 142705 50 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of [125I]-labeled gastrin binding to gastrin/cholecystokinin type B receptorInhibition of [125I]-labeled gastrin binding to gastrin/cholecystokinin type B receptor
ChEMBL 501 6 1 4 6.2 CC(C)Oc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
14843032 145679 0 None - 0 Mouse 6.8 pIC50 = 6.8 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 395 5 1 4 4.7 COc1cccc(-n2c(CCc3c[nH]c4ccccc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
CHEMBL37829 145679 0 None - 0 Mouse 6.8 pIC50 = 6.8 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 395 5 1 4 4.7 COc1cccc(-n2c(CCc3c[nH]c4ccccc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
14802537 65857 0 None - 0 Mouse 6.8 pIC50 = 6.8 Binding
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 614 12 5 5 4.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCC(=O)O)c1ccccc1 10.1016/S0960-894X(00)80685-X
CHEMBL169615 65857 0 None - 0 Mouse 6.8 pIC50 = 6.8 Binding
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 614 12 5 5 4.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCC(=O)O)c1ccccc1 10.1016/S0960-894X(00)80685-X
44280116 106408 0 None - 0 Mouse 6.8 pIC50 = 6.8 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 672 12 3 6 5.8 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
CHEMBL284183 106408 0 None - 0 Mouse 6.8 pIC50 = 6.8 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 672 12 3 6 5.8 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
44280741 163341 0 None - 1 Mouse 6.8 pIC50 = 6.8 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 759 15 4 8 5.8 CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
CHEMBL406844 163341 0 None - 1 Mouse 6.8 pIC50 = 6.8 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 759 15 4 8 5.8 CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
44334305 116496 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 514 9 3 4 4.6 Cc1cccc(NC(=O)N[C@H](COCc2ccccc2)C(=O)N2CCC(C(=O)Nc3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
CHEMBL322913 116496 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 514 9 3 4 4.6 Cc1cccc(NC(=O)N[C@H](COCc2ccccc2)C(=O)N2CCC(C(=O)Nc3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
15689723 113372 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 880 20 9 8 4.3 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1C(F)(F)F)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
CHEMBL3142693 113372 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 880 20 9 8 4.3 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1C(F)(F)F)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
14208227 109041 1 None - 0 Human 5.8 pIC50 = 5.8 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 440 3 1 4 3.9 CN1C(=O)C(NC(=O)c2cc3ccccc3n2C)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL303227 109041 1 None - 0 Human 5.8 pIC50 = 5.8 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 440 3 1 4 3.9 CN1C(=O)C(NC(=O)c2cc3ccccc3n2C)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
14843042 134353 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of [125I]-labeled gastrin binding to gastrin/cholecystokinin type B receptorInhibition of [125I]-labeled gastrin binding to gastrin/cholecystokinin type B receptor
ChEMBL 485 5 1 3 6.5 CCc1cccc(-n2c(CC(C)c3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
CHEMBL36634 134353 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of [125I]-labeled gastrin binding to gastrin/cholecystokinin type B receptorInhibition of [125I]-labeled gastrin binding to gastrin/cholecystokinin type B receptor
ChEMBL 485 5 1 3 6.5 CCc1cccc(-n2c(CC(C)c3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
44349268 23558 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 399 9 3 4 3.1 CC(C)(C)CCCNC(=O)C(CCC(=O)O)NC(=O)c1cnc2ccccc2c1 10.1021/jm00079a003
CHEMBL124509 23558 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 399 9 3 4 3.1 CC(C)(C)CCCNC(=O)C(CCC(=O)O)NC(=O)c1cnc2ccccc2c1 10.1021/jm00079a003
44381914 19775 0 None - 0 Human 4.8 pIC50 = 4.8 Binding
Displacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortexDisplacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortex
ChEMBL 522 14 1 4 4.7 CCCCCN(CCCCC)C(=O)C(CCC(=O)N1CCN(C)CC1)NC(=O)c1ccc2ccccc2c1 10.1016/S0960-894X(00)80681-2
CHEMBL1189721 19775 0 None - 0 Human 4.8 pIC50 = 4.8 Binding
Displacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortexDisplacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortex
ChEMBL 522 14 1 4 4.7 CCCCCN(CCCCC)C(=O)C(CCC(=O)N1CCN(C)CC1)NC(=O)c1ccc2ccccc2c1 10.1016/S0960-894X(00)80681-2
CHEMBL539320 19775 0 None - 0 Human 4.8 pIC50 = 4.8 Binding
Displacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortexDisplacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortex
ChEMBL 522 14 1 4 4.7 CCCCCN(CCCCC)C(=O)C(CCC(=O)N1CCN(C)CC1)NC(=O)c1ccc2ccccc2c1 10.1016/S0960-894X(00)80681-2
44396746 133838 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of 125I]-BH-(Thr,Nle)-CCK-9 binding to human CCK2 receptor expressed in COS-7 cellsInhibition of 125I]-BH-(Thr,Nle)-CCK-9 binding to human CCK2 receptor expressed in COS-7 cells
ChEMBL 637 8 2 6 5.7 C[C@H]1C(=O)N(c2ccc(N(C)C)cc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC3C4CC5CC(C4)CC3C5)C12 10.1021/jm0498755
CHEMBL365620 133838 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of 125I]-BH-(Thr,Nle)-CCK-9 binding to human CCK2 receptor expressed in COS-7 cellsInhibition of 125I]-BH-(Thr,Nle)-CCK-9 binding to human CCK2 receptor expressed in COS-7 cells
ChEMBL 637 8 2 6 5.7 C[C@H]1C(=O)N(c2ccc(N(C)C)cc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC3C4CC5CC(C4)CC3C5)C12 10.1021/jm0498755
44349354 125329 0 None - 0 Rat 4.8 pIC50 = 4.8 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 415 8 3 4 2.9 CCc1cccc(C(=O)NC(CCC(=O)O)C(=O)NN2CCC3(CCCC3)CC2)c1 10.1021/jm00079a003
CHEMBL341505 125329 0 None - 0 Rat 4.8 pIC50 = 4.8 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 415 8 3 4 2.9 CCc1cccc(C(=O)NC(CCC(=O)O)C(=O)NN2CCC3(CCCC3)CC2)c1 10.1021/jm00079a003
44349335 124091 0 None - 0 Rat 4.8 pIC50 = 4.8 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 401 7 3 4 2.6 Cc1cccc(C(=O)NC(CCC(=O)O)C(=O)NN2CCC3(CCCC3)CC2)c1 10.1021/jm00079a003
CHEMBL339707 124091 0 None - 0 Rat 4.8 pIC50 = 4.8 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 401 7 3 4 2.6 Cc1cccc(C(=O)NC(CCC(=O)O)C(=O)NN2CCC3(CCCC3)CC2)c1 10.1021/jm00079a003
44331978 11064 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL 449 12 3 3 3.5 CCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N(CCc1ccccc1)CC(=O)O 10.1016/S0960-894X(96)00546-X
CHEMBL100762 11064 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL 449 12 3 3 3.5 CCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N(CCc1ccccc1)CC(=O)O 10.1016/S0960-894X(96)00546-X
73345199 148523 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranesInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranes
ChEMBL 1019 29 9 11 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCOc1ccccc1)CC(=O)O 10.1021/jm00072a024
CHEMBL385918 148523 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranesInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranes
ChEMBL 1019 29 9 11 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCOc1ccccc1)CC(=O)O 10.1021/jm00072a024
44349390 24229 0 None - 0 Rat 4.8 pIC50 = 4.8 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 417 8 3 5 2.3 COc1cccc(C(=O)NC(CCC(=O)O)C(=O)NN2CCC3(CCCC3)CC2)c1 10.1021/jm00079a003
CHEMBL125770 24229 0 None - 0 Rat 4.8 pIC50 = 4.8 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 417 8 3 5 2.3 COc1cccc(C(=O)NC(CCC(=O)O)C(=O)NN2CCC3(CCCC3)CC2)c1 10.1021/jm00079a003
10699165 118230 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 625 7 1 4 6.9 CC(C)N(C(=O)CN1C(=O)C(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc21)c1ccc(C(F)(F)F)cc1 10.1021/jm970265x
CHEMBL327552 118230 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 625 7 1 4 6.9 CC(C)N(C(=O)CN1C(=O)C(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc21)c1ccc(C(F)(F)F)cc1 10.1021/jm970265x
44359338 175445 0 None - 0 Mouse 6.8 pIC50 = 6.8 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 489 6 3 3 5.3 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1CC2CCC1C2 10.1021/jm970065l
CHEMBL436411 175445 0 None - 0 Mouse 6.8 pIC50 = 6.8 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 489 6 3 3 5.3 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1CC2CCC1C2 10.1021/jm970065l
44280180 109410 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 655 11 5 8 3.6 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCSCc3csc(N=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
CHEMBL30430 109410 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 655 11 5 8 3.6 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCSCc3csc(N=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
CHEMBL292097 217664 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Compound was tested for its binding affinity towards Cholecystokinin type B receptor in cortical membranes (CNS)Compound was tested for its binding affinity towards Cholecystokinin type B receptor in cortical membranes (CNS)
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(01)81005-2
6957640 166140 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
In vitro test for inhibition of [125I]CCK binding to Cholecystokinin type B receptor from guinea pig cortical membranes was determinedIn vitro test for inhibition of [125I]CCK binding to Cholecystokinin type B receptor from guinea pig cortical membranes was determined
ChEMBL 404 3 2 3 4.5 Cc1cccc(NC(=O)N[C@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(01)80987-2
CHEMBL410035 166140 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
In vitro test for inhibition of [125I]CCK binding to Cholecystokinin type B receptor from guinea pig cortical membranes was determinedIn vitro test for inhibition of [125I]CCK binding to Cholecystokinin type B receptor from guinea pig cortical membranes was determined
ChEMBL 404 3 2 3 4.5 Cc1cccc(NC(=O)N[C@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(01)80987-2
16100407 89446 0 None -112 3 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1132 28 13 13 1.7 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc1cc2ccccc2[nH]1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061268p
CHEMBL217957 89446 0 None -112 3 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1132 28 13 13 1.7 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc1cc2ccccc2[nH]1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061268p
44279852 106138 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 690 11 3 5 5.6 O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL282476 106138 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 690 11 3 5 5.6 O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
10603713 118425 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 605 8 1 5 6.0 COc1ccc(N(C(=O)CN2C(=O)C(Cc3n[nH]c4cccc(F)c34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm970265x
CHEMBL328586 118425 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 605 8 1 5 6.0 COc1ccc(N(C(=O)CN2C(=O)C(Cc3n[nH]c4cccc(F)c34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm970265x
CHEMBL282175 106097 0 None - 1 Human 7.8 pIC50 = 7.8 Binding
Inhibitory activity against gastrin receptor.Inhibitory activity against gastrin receptor.
ChEMBL 769 16 6 11 4.6 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CCOC(=O)NCCCC(=O)NCCSCc3csc(C=C(N)N)n3)C2=O)c1 10.1016/S0960-894X(96)00249-1
44331850 215031 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL 600 13 3 4 4.7 O=C(Cc1c[nH]c2ccccc12)N[C@@H](CCc1ccccc1)C(=O)N(CCC1CCCCC1)CC(=O)N1CCC[C@H]1C(=O)O 10.1016/S0960-894X(96)00546-X
CHEMBL98788 215031 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL 600 13 3 4 4.7 O=C(Cc1c[nH]c2ccccc12)N[C@@H](CCc1ccccc1)C(=O)N(CCC1CCCCC1)CC(=O)N1CCC[C@H]1C(=O)O 10.1016/S0960-894X(96)00546-X
145988494 173962 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Displacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting methodDisplacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting method
ChEMBL 425 5 2 7 3.6 CCOc1ccc(-n2c(N/N=C3\C(=O)Nc4ccccc43)nc3ccccc3c2=O)cc1 10.1039/C7MD00171A
CHEMBL4291306 173962 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Displacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting methodDisplacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting method
ChEMBL 425 5 2 7 3.6 CCOc1ccc(-n2c(N/N=C3\C(=O)Nc4ccccc43)nc3ccccc3c2=O)cc1 10.1039/C7MD00171A
CHEMBL263155 217339 0 None - 0 Bovine 6.8 pIC50 = 6.8 Binding
Concentration inhibiting [3H]propionyl-CCK-8 binding to cholecystokinin type B receptor of bovine striatum.Concentration inhibiting [3H]propionyl-CCK-8 binding to cholecystokinin type B receptor of bovine striatum.
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)NC(C)(C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00100a033
444998 216098 30 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00173a006
CHEMBL216166 216098 30 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00173a006
443375 214385 45 None -316 5 Human 6.8 pIC50 = 6.8 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
CHEMBL9506 214385 45 None -316 5 Human 6.8 pIC50 = 6.8 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
44354128 27066 0 None - 0 Mouse 6.8 pIC50 = 6.8 Binding
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 628 13 5 5 4.7 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@@H](CNC(=O)CCC(=O)O)Cc1ccccc1 10.1021/jm00105a062
CHEMBL130578 27066 0 None - 0 Mouse 6.8 pIC50 = 6.8 Binding
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 628 13 5 5 4.7 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@@H](CNC(=O)CCC(=O)O)Cc1ccccc1 10.1021/jm00105a062
14802521 65858 0 None - 0 Mouse 6.8 pIC50 = 6.8 Binding
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 628 13 5 5 4.7 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CNC(=O)CCC(=O)O)Cc1ccccc1 10.1016/S0960-894X(00)80685-X
CHEMBL169616 65858 0 None - 0 Mouse 6.8 pIC50 = 6.8 Binding
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 628 13 5 5 4.7 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CNC(=O)CCC(=O)O)Cc1ccccc1 10.1016/S0960-894X(00)80685-X
44356717 123558 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 513 5 3 5 4.7 CN1C(=O)C(NC(=O)Nc2cccc(CNC(=O)OC(C)(C)C)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL337722 123558 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 513 5 3 5 4.7 CN1C(=O)C(NC(=O)Nc2cccc(CNC(=O)OC(C)(C)C)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
367893 58394 1 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 429 14 3 3 4.3 CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)O)NC(=O)c1cc2ccccc2[nH]1 10.1021/jm00164a020
CHEMBL158362 58394 1 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 429 14 3 3 4.3 CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)O)NC(=O)c1cc2ccccc2[nH]1 10.1021/jm00164a020
443375 214385 45 None -316 5 Human 6.8 pIC50 = 6.8 Binding
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00164a020
CHEMBL9506 214385 45 None -316 5 Human 6.8 pIC50 = 6.8 Binding
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00164a020
44334320 11795 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 531 9 2 4 4.6 Cc1cccc(NC(=O)N[C@H](C[S+]([O-])Cc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
CHEMBL105132 11795 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 531 9 2 4 4.6 Cc1cccc(NC(=O)N[C@H](C[S+]([O-])Cc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
CHEMBL433365 220417 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL None None None CC(C)(C)OC(=O)N1c2ccccc2C[C@@H]1C(=O)N1[C@H](c2ccccc2)CC[C@@H]1C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O 10.1016/S0960-894X(96)00546-X
196641 211177 12 None - 0 Human 5.8 pIC50 = 5.8 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 447 3 1 3 4.0 CN1C(=O)C(NC(=O)c2ccc(Br)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
CHEMBL71950 211177 12 None - 0 Human 5.8 pIC50 = 5.8 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 447 3 1 3 4.0 CN1C(=O)C(NC(=O)c2ccc(Br)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
90663984 113591 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 841 21 8 8 3.4 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(F)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL3144553 113591 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 841 21 8 8 3.4 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(F)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
90663985 113592 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 853 22 8 9 3.3 COc1ccc(/C=C\C(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 10.1021/jm00089a010
CHEMBL3144554 113592 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 853 22 8 9 3.3 COc1ccc(/C=C\C(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 10.1021/jm00089a010
44279862 105906 0 None - 1 Mouse 5.8 pIC50 = 5.8 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 702 13 3 7 5.9 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL281017 105906 0 None - 1 Mouse 5.8 pIC50 = 5.8 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 702 13 3 7 5.9 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
19766161 65957 0 None - 0 Human 4.8 pIC50 = 4.8 Binding
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 403 4 3 3 3.4 O=C(O)CN1C(=O)C(NC(=O)Nc2cccc3ccccc23)CCc2ccccc21 10.1016/S0960-894X(00)80683-6
CHEMBL170068 65957 0 None - 0 Human 4.8 pIC50 = 4.8 Binding
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 403 4 3 3 3.4 O=C(O)CN1C(=O)C(NC(=O)Nc2cccc3ccccc23)CCc2ccccc21 10.1016/S0960-894X(00)80683-6
1043 8363 14 None - 29 Mouse 4.8 pIC50 = 4.8 Binding
Concentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranesConcentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranes
ChEMBL 581 4 3 6 2.0 O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 10.1016/S0960-894X(00)80644-7
149 8363 14 None - 29 Mouse 4.8 pIC50 = 4.8 Binding
Concentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranesConcentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranes
ChEMBL 581 4 3 6 2.0 O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 10.1016/S0960-894X(00)80644-7
8223 8363 14 None - 29 Mouse 4.8 pIC50 = 4.8 Binding
Concentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranesConcentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranes
ChEMBL 581 4 3 6 2.0 O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 10.1016/S0960-894X(00)80644-7
CHEMBL442 8363 14 None - 29 Mouse 4.8 pIC50 = 4.8 Binding
Concentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranesConcentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranes
ChEMBL 581 4 3 6 2.0 O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 10.1016/S0960-894X(00)80644-7
DB00696 8363 14 None - 29 Mouse 4.8 pIC50 = 4.8 Binding
Concentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranesConcentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranes
ChEMBL 581 4 3 6 2.0 O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 10.1016/S0960-894X(00)80644-7
CHEMBL435339 220444 0 None - 0 Mouse 4.8 pIC50 = 4.8 Binding
Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N1C[C@@H](Cc2ccccc2)NC(=O)[C@@H]1CC(=O)O 10.1016/S0960-894X(01)80253-5
14208200 211496 0 None - 0 Human 4.8 pIC50 = 4.8 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 422 5 3 3 4.0 O=C(CCc1c[nH]c2ccccc12)NC1N=C(c2ccccc2)c2ccccc2NC1=O 10.1021/jm00120a002
CHEMBL74181 211496 0 None - 0 Human 4.8 pIC50 = 4.8 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 422 5 3 3 4.0 O=C(CCc1c[nH]c2ccccc12)NC1N=C(c2ccccc2)c2ccccc2NC1=O 10.1021/jm00120a002
14720390 56164 0 None - 0 Human 4.8 pIC50 = 4.8 Binding
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 373 10 3 3 2.8 CCCN(CCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1cc2ccccc2[nH]1 10.1021/jm00164a020
CHEMBL156415 56164 0 None - 0 Human 4.8 pIC50 = 4.8 Binding
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 373 10 3 3 2.8 CCCN(CCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1cc2ccccc2[nH]1 10.1021/jm00164a020
44303653 107557 0 None - 0 Mouse 6.8 pIC50 = 6.8 Binding
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 557 10 2 5 5.7 CN(C)Cc1oc2ccccc2c1CC(C)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 10.1016/S0960-894X(97)00356-9
CHEMBL292957 107557 0 None - 0 Mouse 6.8 pIC50 = 6.8 Binding
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 557 10 2 5 5.7 CN(C)Cc1oc2ccccc2c1CC(C)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 10.1016/S0960-894X(97)00356-9
CHEMBL379405 219044 0 None -10 4 Human 5.8 pIC50 = 5.8 Binding
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm050921q
44408411 168089 0 None -3548 4 Human 5.8 pIC50 = 5.8 Binding
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1242 31 11 15 4.4 CCCC[C@@H](C(=O)N[C@@H](Cc1cn(C(C)=O)c2ccccc12)C(=O)O)N(C(=O)Nc1ccccc1Cl)C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)N(C)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O 10.1021/jm050851n
CHEMBL412331 168089 0 None -3548 4 Human 5.8 pIC50 = 5.8 Binding
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1242 31 11 15 4.4 CCCC[C@@H](C(=O)N[C@@H](Cc1cn(C(C)=O)c2ccccc12)C(=O)O)N(C(=O)Nc1ccccc1Cl)C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)N(C)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O 10.1021/jm050851n
10817395 113919 0 None - 0 Human 4.8 pIC50 = 4.8 Binding
Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8
ChEMBL 600 8 1 4 6.9 COc1ccc(N(C(=O)CN2C(=O)C(C)(Cc3c[nH]c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm960249k
CHEMBL316164 113919 0 None - 0 Human 4.8 pIC50 = 4.8 Binding
Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8
ChEMBL 600 8 1 4 6.9 COc1ccc(N(C(=O)CN2C(=O)C(C)(Cc3c[nH]c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm960249k
10817395 113919 0 None - 0 Human 4.8 pIC50 = 4.8 Binding
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 600 8 1 4 6.9 COc1ccc(N(C(=O)CN2C(=O)C(C)(Cc3c[nH]c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm970265x
CHEMBL316164 113919 0 None - 0 Human 4.8 pIC50 = 4.8 Binding
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 600 8 1 4 6.9 COc1ccc(N(C(=O)CN2C(=O)C(C)(Cc3c[nH]c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm970265x
52949124 7663 4 None 2 2 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
9055 7663 4 None 2 2 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
CHEMBL1269258 7663 4 None 2 2 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
DB12694 7663 4 None 2 2 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
73349808 168572 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranesInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranes
ChEMBL 1019 29 9 11 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCOc1ccccc1)CC(=O)O 10.1021/jm00072a024
CHEMBL414180 168572 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranesInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranes
ChEMBL 1019 29 9 11 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCOc1ccccc1)CC(=O)O 10.1021/jm00072a024
44280375 105884 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 559 8 3 4 5.4 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)Nc1ccc(C(=O)O)cc1 10.1021/jm950372w
CHEMBL280832 105884 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 559 8 3 4 5.4 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)Nc1ccc(C(=O)O)cc1 10.1021/jm950372w
10768419 35881 0 None - 0 Mouse 5.8 pIC50 = 5.8 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 525 10 5 5 3.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC(CC(=O)O)CC(=O)O 10.1021/jm970065l
CHEMBL138127 35881 0 None - 0 Mouse 5.8 pIC50 = 5.8 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 525 10 5 5 3.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC(CC(=O)O)CC(=O)O 10.1021/jm970065l
44327699 214261 0 None - 0 Mouse 6.8 pIC50 = 6.8 Binding
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 641 15 2 5 7.2 COC(=O)CCCCCCN(CCc1ccccc1)C(=O)[C@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1016/S0960-894X(01)80769-1
CHEMBL94352 214261 0 None - 0 Mouse 6.8 pIC50 = 6.8 Binding
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 641 15 2 5 7.2 COC(=O)CCCCCCN(CCc1ccccc1)C(=O)[C@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1016/S0960-894X(01)80769-1
10698051 213310 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8
ChEMBL 557 7 1 4 5.9 CC(C)N(C(=O)CN1C(=O)C(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/jm960249k
CHEMBL88545 213310 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8
ChEMBL 557 7 1 4 5.9 CC(C)N(C(=O)CN1C(=O)C(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/jm960249k
10439504 99075 0 None - 0 Mouse 6.8 pIC50 = 6.8 Binding
Evaluated for Cholecystokinin type B receptor antagonistic activity in which 20 pM [125I]BH-CCK-8S was used to label CCKB/gastrin binding sites in mouse cortical homogenatesEvaluated for Cholecystokinin type B receptor antagonistic activity in which 20 pM [125I]BH-CCK-8S was used to label CCKB/gastrin binding sites in mouse cortical homogenates
ChEMBL 675 8 5 6 5.1 O=C(O)c1cc(NC(=O)C2Cc3ccccc3CN2C(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1016/S0960-894X(97)00211-4
CHEMBL24276 99075 0 None - 0 Mouse 6.8 pIC50 = 6.8 Binding
Evaluated for Cholecystokinin type B receptor antagonistic activity in which 20 pM [125I]BH-CCK-8S was used to label CCKB/gastrin binding sites in mouse cortical homogenatesEvaluated for Cholecystokinin type B receptor antagonistic activity in which 20 pM [125I]BH-CCK-8S was used to label CCKB/gastrin binding sites in mouse cortical homogenates
ChEMBL 675 8 5 6 5.1 O=C(O)c1cc(NC(=O)C2Cc3ccccc3CN2C(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1016/S0960-894X(97)00211-4
10032956 174815 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
In vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cellsIn vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL 742 17 7 6 5.8 Cc1ccccc1NC(=O)NCCCC[C@H](CNC(=O)[C@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3)NC(=O)CCC(=O)O 10.1021/jm00017a022
CHEMBL432258 174815 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
In vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cellsIn vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL 742 17 7 6 5.8 Cc1ccccc1NC(=O)NCCCC[C@H](CNC(=O)[C@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3)NC(=O)CCC(=O)O 10.1021/jm00017a022
10698051 213310 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 557 7 1 4 5.9 CC(C)N(C(=O)CN1C(=O)C(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/jm970265x
CHEMBL88545 213310 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 557 7 1 4 5.9 CC(C)N(C(=O)CN1C(=O)C(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/jm970265x
155539345 179612 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1850 72 16 23 3.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4514283 179612 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1850 72 16 23 3.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
44210424 125996 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 423 4 2 4 3.8 Cc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)OC(C)(C)C)C2=O)c1 10.1016/S0960-894X(00)80683-6
CHEMBL34335 125996 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 423 4 2 4 3.8 Cc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)OC(C)(C)C)C2=O)c1 10.1016/S0960-894X(00)80683-6
22354599 201584 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligandBinding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligand
ChEMBL 517 6 2 5 4.9 Cc1cccc(NC(=O)NC2N=C(c3ccncc3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1 10.1016/0960-894X(95)00557-A
CHEMBL538912 201584 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligandBinding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligand
ChEMBL 517 6 2 5 4.9 Cc1cccc(NC(=O)NC2N=C(c3ccncc3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1 10.1016/0960-894X(95)00557-A
71456207 85399 0 None - 0 Mouse 7.8 pIC50 = 7.8 Binding
Evaluated for inhibition of CCK-B receptor by displacing [125I]bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of CCK-B receptor by displacing [125I]bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 655 12 5 7 4.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CSc1c[nH]nn1)c1ccccc1 10.1021/jm00092a007
CHEMBL2112331 85399 0 None - 0 Mouse 7.8 pIC50 = 7.8 Binding
Evaluated for inhibition of CCK-B receptor by displacing [125I]bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of CCK-B receptor by displacing [125I]bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 655 12 5 7 4.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CSc1c[nH]nn1)c1ccccc1 10.1021/jm00092a007
73349808 168572 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Inhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic aciniInhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic acini
ChEMBL 1019 29 9 11 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCOc1ccccc1)CC(=O)O 10.1021/jm00072a024
CHEMBL414180 168572 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Inhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic aciniInhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic acini
ChEMBL 1019 29 9 11 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCOc1ccccc1)CC(=O)O 10.1021/jm00072a024
14888721 84012 0 None - 0 Bovine 7.8 pIC50 = 7.8 Binding
Inhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranesInhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranes
ChEMBL 1055 30 11 14 -0.2 CSCC[C@H](NC(=O)[C@H](Cc1ccc(Cc2nnn[nH]2)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00107a037
CHEMBL2079551 84012 0 None - 0 Bovine 7.8 pIC50 = 7.8 Binding
Inhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranesInhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranes
ChEMBL 1055 30 11 14 -0.2 CSCC[C@H](NC(=O)[C@H](Cc1ccc(Cc2nnn[nH]2)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00107a037
44318235 18849 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 513 7 2 4 3.0 CCN(CC)C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C(c2cccc[n+]2C)c2ccccc21 10.1021/jm9608523
CHEMBL1183721 18849 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 513 7 2 4 3.0 CCN(CC)C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C(c2cccc[n+]2C)c2ccccc21 10.1021/jm9608523
CHEMBL314846 18849 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 513 7 2 4 3.0 CCN(CC)C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C(c2cccc[n+]2C)c2ccccc21 10.1021/jm9608523
44333311 11031 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortexDisplacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortex
ChEMBL 476 6 2 5 3.5 CCCc1cccc(NC(=O)NC2N=C(N3CCN(C)CC3)c3ccccc3N(CCC)C2=O)c1 10.1016/0960-894X(95)00530-0
CHEMBL100502 11031 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortexDisplacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortex
ChEMBL 476 6 2 5 3.5 CCCc1cccc(NC(=O)NC2N=C(N3CCN(C)CC3)c3ccccc3N(CCC)C2=O)c1 10.1016/0960-894X(95)00530-0
155550030 180681 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter methodDisplacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter method
ChEMBL 1399 39 16 19 -2.7 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.9b01936
CHEMBL4540191 180681 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter methodDisplacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter method
ChEMBL 1399 39 16 19 -2.7 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.9b01936
19766169 172345 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 443 4 2 4 4.2 CC(C)(C)OC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)CCc2ccccc21 10.1016/S0960-894X(00)80683-6
CHEMBL424211 172345 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 443 4 2 4 4.2 CC(C)(C)OC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)CCc2ccccc21 10.1016/S0960-894X(00)80683-6
14208286 74458 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 395 4 1 3 3.7 CN1C(=O)[C@@H](NC(=O)/C=C/c2ccccc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
CHEMBL1907661 74458 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 395 4 1 3 3.7 CN1C(=O)[C@@H](NC(=O)/C=C/c2ccccc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
44354127 123513 0 None - 0 Mouse 6.8 pIC50 = 6.8 Binding
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 628 13 5 5 4.7 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](CNC(=O)CCC(=O)O)Cc1ccccc1 10.1021/jm00105a062
CHEMBL337461 123513 0 None - 0 Mouse 6.8 pIC50 = 6.8 Binding
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 628 13 5 5 4.7 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](CNC(=O)CCC(=O)O)Cc1ccccc1 10.1021/jm00105a062
14802522 66346 0 None - 1 Mouse 6.8 pIC50 = 6.8 Binding
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 628 13 5 5 4.7 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CNC(=O)CCC(=O)O)Cc1ccccc1 10.1016/S0960-894X(00)80685-X
CHEMBL171806 66346 0 None - 1 Mouse 6.8 pIC50 = 6.8 Binding
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 628 13 5 5 4.7 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CNC(=O)CCC(=O)O)Cc1ccccc1 10.1016/S0960-894X(00)80685-X
44381821 127403 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Inhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptorInhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptor
ChEMBL 689 18 7 8 2.8 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@H](C#N)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(97)00107-8
CHEMBL354632 127403 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Inhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptorInhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptor
ChEMBL 689 18 7 8 2.8 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@H](C#N)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(97)00107-8
44280740 107183 0 None - 1 Mouse 6.8 pIC50 = 6.8 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 787 17 4 8 6.3 CN1C(=O)[C@H](NC(=O)Nc2cccc(CCOC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
CHEMBL290122 107183 0 None - 1 Mouse 6.8 pIC50 = 6.8 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 787 17 4 8 6.3 CN1C(=O)[C@H](NC(=O)Nc2cccc(CCOC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
44334225 11760 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 522 7 2 6 3.1 Cc1cccc(NC(=O)N[C@H](COC(=O)N2CCOCC2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
CHEMBL104958 11760 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 522 7 2 6 3.1 Cc1cccc(NC(=O)N[C@H](COC(=O)N2CCOCC2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
14208271 109672 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 455 3 1 3 4.4 CN1C(=O)C(NC(=O)c2ccc(C(F)(F)F)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL305951 109672 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 455 3 1 3 4.4 CN1C(=O)C(NC(=O)c2ccc(C(F)(F)F)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
44381201 168455 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
In vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranesIn vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranes
ChEMBL 1062 29 9 12 3.6 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)CCc1ccccc1 10.1016/S0960-894X(00)80679-4
CHEMBL413186 168455 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
In vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranesIn vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranes
ChEMBL 1062 29 9 12 3.6 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)CCc1ccccc1 10.1016/S0960-894X(00)80679-4
44375217 63326 0 None - 0 Mouse 5.8 pIC50 = 5.8 Binding
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 582 12 5 7 3.8 O=C(O)CN(Cc1ccccc1)S(=O)(=O)c1ccc(N/N=C(/S)NCCc2c[nH]c3ccccc23)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
CHEMBL163974 63326 0 None - 0 Mouse 5.8 pIC50 = 5.8 Binding
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 582 12 5 7 3.8 O=C(O)CN(Cc1ccccc1)S(=O)(=O)c1ccc(N/N=C(/S)NCCc2c[nH]c3ccccc23)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
73349808 168572 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat TcellsInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat Tcells
ChEMBL 1019 29 9 11 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCOc1ccccc1)CC(=O)O 10.1021/jm00072a024
CHEMBL414180 168572 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat TcellsInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat Tcells
ChEMBL 1019 29 9 11 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCOc1ccccc1)CC(=O)O 10.1021/jm00072a024
90663977 113577 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 823 21 8 8 3.3 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL3144539 113577 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 823 21 8 8 3.3 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL169174 215615 0 None - 0 Mouse 4.8 pIC50 = 4.8 Binding
Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1)C(=O)N1CC(=O)N[C@@H](Cc2ccccc2)C1 10.1016/S0960-894X(01)80253-5
14208199 109849 0 None - 0 Human 4.8 pIC50 = 4.8 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 394 3 3 3 3.7 O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1c[nH]c2ccccc12 10.1021/jm00120a002
CHEMBL307370 109849 0 None - 0 Human 4.8 pIC50 = 4.8 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 394 3 3 3 3.7 O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1c[nH]c2ccccc12 10.1021/jm00120a002
14208246 211461 0 None - 0 Human 4.8 pIC50 = 4.8 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 407 3 2 3 4.0 O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccccc1Cl 10.1021/jm00120a002
CHEMBL73892 211461 0 None - 0 Human 4.8 pIC50 = 4.8 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 407 3 2 3 4.0 O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccccc1Cl 10.1021/jm00120a002
10462874 105612 0 None - 0 Mouse 4.8 pIC50 = 4.8 Binding
Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 766 16 6 5 7.1 O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1)NCCCCNC(=O)Nc1ccccc1Cl 10.1016/S0960-894X(00)80687-3
CHEMBL278780 105612 0 None - 0 Mouse 4.8 pIC50 = 4.8 Binding
Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 766 16 6 5 7.1 O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1)NCCCCNC(=O)Nc1ccccc1Cl 10.1016/S0960-894X(00)80687-3
44396655 128828 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Inhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenatesInhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenates
ChEMBL 608 8 2 5 5.7 C[C@H]1C(=O)N(Cc2ccccc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC3C4CC5CC(C4)CC3C5)C12 10.1021/jm0498755
CHEMBL359589 128828 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Inhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenatesInhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenates
ChEMBL 608 8 2 5 5.7 C[C@H]1C(=O)N(Cc2ccccc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC3C4CC5CC(C4)CC3C5)C12 10.1021/jm0498755
44280974 106783 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 690 11 3 5 5.4 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCC2CCCCC2C1 10.1021/jm950372w
CHEMBL286763 106783 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 690 11 3 5 5.4 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCC2CCCCC2C1 10.1021/jm950372w
44280225 106739 0 None - 1 Human 6.7 pIC50 = 6.7 Binding
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 743 15 4 7 5.4 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL286475 106739 0 None - 1 Human 6.7 pIC50 = 6.7 Binding
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 743 15 4 7 5.4 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 10.1016/S0960-894X(96)00248-X
44280620 110693 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 686 15 4 5 5.2 O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NCCCc1ccccc1 10.1021/jm950372w
CHEMBL30924 110693 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 686 15 4 5 5.2 O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NCCCc1ccccc1 10.1021/jm950372w
44303511 166539 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Compound was tested for its binding affinity towards Cholecystokinin type B receptor in cortical membranes (CNS)Compound was tested for its binding affinity towards Cholecystokinin type B receptor in cortical membranes (CNS)
ChEMBL 750 18 4 10 5.7 CCCC[C@@H](C(=O)N[C@@H](CC(=O)OCc1ccccc1)[C@@H](Cc1ccccc1)C(N)=O)n1nnnc1[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1016/S0960-894X(01)81005-2
CHEMBL410511 166539 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Compound was tested for its binding affinity towards Cholecystokinin type B receptor in cortical membranes (CNS)Compound was tested for its binding affinity towards Cholecystokinin type B receptor in cortical membranes (CNS)
ChEMBL 750 18 4 10 5.7 CCCC[C@@H](C(=O)N[C@@H](CC(=O)OCc1ccccc1)[C@@H](Cc1ccccc1)C(N)=O)n1nnnc1[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1016/S0960-894X(01)81005-2
2802894 9182 33 None - 0 Mouse 7.7 pIC50 = 7.7 Binding
Half maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortexHalf maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 435 3 2 2 4.9 Brc1ccc(cc1)NC(=O)N1NC(=O)[C@H]([C@@H]1c1ccccc1)c1ccccc1 10.1021/jm000937a
3509 9182 33 None - 0 Mouse 7.7 pIC50 = 7.7 Binding
Half maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortexHalf maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 435 3 2 2 4.9 Brc1ccc(cc1)NC(=O)N1NC(=O)[C@H]([C@@H]1c1ccccc1)c1ccccc1 10.1021/jm000937a
CHEMBL333081 9182 33 None - 0 Mouse 7.7 pIC50 = 7.7 Binding
Half maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortexHalf maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 435 3 2 2 4.9 Brc1ccc(cc1)NC(=O)N1NC(=O)[C@H]([C@@H]1c1ccccc1)c1ccccc1 10.1021/jm000937a
71449099 85589 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 414 4 3 4 3.0 CN1C(=O)[C@H](NC(=O)NCc2cccc(O)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL2112751 85589 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 414 4 3 4 3.0 CN1C(=O)[C@H](NC(=O)NCc2cccc(O)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
44281292 121572 0 None - 1 Human 7.7 pIC50 = 7.7 Binding
Inhibitory activity against gastrin receptor.Inhibitory activity against gastrin receptor.
ChEMBL 816 17 5 9 5.0 CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCCNC(=O)CC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
CHEMBL33398 121572 0 None - 1 Human 7.7 pIC50 = 7.7 Binding
Inhibitory activity against gastrin receptor.Inhibitory activity against gastrin receptor.
ChEMBL 816 17 5 9 5.0 CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCCNC(=O)CC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
2802894 9182 33 None - 0 Mouse 7.7 pIC50 = 7.7 Binding
The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in mouse brain at a pH of 6.5The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in mouse brain at a pH of 6.5
ChEMBL 435 3 2 2 4.9 Brc1ccc(cc1)NC(=O)N1NC(=O)[C@H]([C@@H]1c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80684-8
3509 9182 33 None - 0 Mouse 7.7 pIC50 = 7.7 Binding
The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in mouse brain at a pH of 6.5The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in mouse brain at a pH of 6.5
ChEMBL 435 3 2 2 4.9 Brc1ccc(cc1)NC(=O)N1NC(=O)[C@H]([C@@H]1c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80684-8
CHEMBL333081 9182 33 None - 0 Mouse 7.7 pIC50 = 7.7 Binding
The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in mouse brain at a pH of 6.5The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in mouse brain at a pH of 6.5
ChEMBL 435 3 2 2 4.9 Brc1ccc(cc1)NC(=O)N1NC(=O)[C@H]([C@@H]1c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80684-8
145979412 173333 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Displacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting methodDisplacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting method
ChEMBL 459 3 2 6 3.9 O=C1Nc2ccccc2/C1=N/Nc1nc2ccccc2c(=O)n1-c1cccc(Br)c1 10.1039/C7MD00171A
CHEMBL4279570 173333 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Displacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting methodDisplacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting method
ChEMBL 459 3 2 6 3.9 O=C1Nc2ccccc2/C1=N/Nc1nc2ccccc2c(=O)n1-c1cccc(Br)c1 10.1039/C7MD00171A
9832467 151071 0 None -13 5 Dog 7.7 pIC50 = 7.7 Binding
Concentration required to inhibit the binding of [125I]-BH-CCK-8S radioligand to canine gastric mucosa CCK2 receptorConcentration required to inhibit the binding of [125I]-BH-CCK-8S radioligand to canine gastric mucosa CCK2 receptor
ChEMBL 477 7 3 4 5.9 O=C(O)c1cccc(NC(=O)c2nc(C3CCCCC3)[nH]c2COC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
CHEMBL390519 151071 0 None -13 5 Dog 7.7 pIC50 = 7.7 Binding
Concentration required to inhibit the binding of [125I]-BH-CCK-8S radioligand to canine gastric mucosa CCK2 receptorConcentration required to inhibit the binding of [125I]-BH-CCK-8S radioligand to canine gastric mucosa CCK2 receptor
ChEMBL 477 7 3 4 5.9 O=C(O)c1cccc(NC(=O)c2nc(C3CCCCC3)[nH]c2COC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
10319892 65865 2 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 418 3 2 3 4.3 CN1C(=O)[C@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL169661 65865 2 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 418 3 2 3 4.3 CN1C(=O)[C@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
10838382 126109 0 None - 0 Mouse 7.7 pIC50 = 7.7 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 478 6 3 4 4.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NN1CCCCC1 10.1021/jm970065l
CHEMBL344211 126109 0 None - 0 Mouse 7.7 pIC50 = 7.7 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 478 6 3 4 4.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NN1CCCCC1 10.1021/jm970065l
10555387 36867 0 None - 0 Mouse 7.7 pIC50 = 7.7 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 589 10 3 3 7.0 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC(Cc1ccccc1)Cc1ccccc1 10.1021/jm970065l
CHEMBL138952 36867 0 None - 0 Mouse 7.7 pIC50 = 7.7 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 589 10 3 3 7.0 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC(Cc1ccccc1)Cc1ccccc1 10.1021/jm970065l
10032955 174814 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cellsIn vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL 742 17 7 6 5.8 Cc1ccccc1NC(=O)NCCCC[C@H](CNC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3)NC(=O)CCC(=O)O 10.1021/jm00017a022
CHEMBL432256 174814 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cellsIn vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL 742 17 7 6 5.8 Cc1ccccc1NC(=O)NCCCC[C@H](CNC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3)NC(=O)CCC(=O)O 10.1021/jm00017a022
10093957 211413 1 None - 0 Human 6.7 pIC50 = 6.7 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 426 3 2 3 3.9 CN1C(=O)C(NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL73522 211413 1 None - 0 Human 6.7 pIC50 = 6.7 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 426 3 2 3 3.9 CN1C(=O)C(NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
73351326 89158 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat TcellsInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat Tcells
ChEMBL 1017 29 9 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCCc1ccccc1)CC(=O)O 10.1021/jm00072a024
CHEMBL217234 89158 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat TcellsInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat Tcells
ChEMBL 1017 29 9 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCCc1ccccc1)CC(=O)O 10.1021/jm00072a024
14843053 106936 0 None - 0 Mouse 6.7 pIC50 = 6.7 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 409 4 1 5 4.4 O=c1c2ccccc2nc(CCc2c[nH]c3ccccc23)n1-c1ccc2c(c1)OCO2 10.1021/jm00108a040
CHEMBL287913 106936 0 None - 0 Mouse 6.7 pIC50 = 6.7 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 409 4 1 5 4.4 O=c1c2ccccc2nc(CCc2c[nH]c3ccccc23)n1-c1ccc2c(c1)OCO2 10.1021/jm00108a040
10369346 31740 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 518 6 3 5 4.4 Cc1ccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)Nc3ccncc3)C2=O)cc1 10.1021/jm00078a018
CHEMBL134618 31740 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 518 6 3 5 4.4 Cc1ccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)Nc3ccncc3)C2=O)cc1 10.1021/jm00078a018
44370694 54784 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 488 15 2 4 4.8 CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)N1CCCC1)NC(=O)Nc1cccc(OC)c1 10.1021/jm00164a020
CHEMBL155017 54784 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 488 15 2 4 4.8 CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)N1CCCC1)NC(=O)Nc1cccc(OC)c1 10.1021/jm00164a020
44329331 114842 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 540 6 3 3 5.9 Cc1ccc([C@H]2C[C@@H](NC(=O)Nc3cccc(C)c3)C(=O)N(CC(=O)NC(C)(C)C)[C@@H](c3ccccc3)C2)cc1 10.1016/S0960-894X(01)80832-5
CHEMBL319504 114842 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 540 6 3 3 5.9 Cc1ccc([C@H]2C[C@@H](NC(=O)Nc3cccc(C)c3)C(=O)N(CC(=O)NC(C)(C)C)[C@@H](c3ccccc3)C2)cc1 10.1016/S0960-894X(01)80832-5
44280713 106808 0 None - 1 Human 6.7 pIC50 = 6.7 Binding
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 740 15 6 9 3.6 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCCC(=O)NCCSCc3csc(N=C(N)N)n3)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL286907 106808 0 None - 1 Human 6.7 pIC50 = 6.7 Binding
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 740 15 6 9 3.6 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCCC(=O)NCCSCc3csc(N=C(N)N)n3)C2=O)c1 10.1016/S0960-894X(96)00248-X
10769675 213978 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 587 8 1 5 5.9 COc1cccc(N(C(=O)CN2C(=O)C(Cc3n[nH]c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)c1 10.1021/jm970265x
CHEMBL92586 213978 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 587 8 1 5 5.9 COc1cccc(N(C(=O)CN2C(=O)C(Cc3n[nH]c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)c1 10.1021/jm970265x
CHEMBL319340 217995 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL None None None CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1Cl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
CHEMBL2112688 216027 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity towards Cholecystokinin type B receptor was determined in guinea pig cortex using [3H]SNF8702 as radioligandBinding affinity towards Cholecystokinin type B receptor was determined in guinea pig cortex using [3H]SNF8702 as radioligand
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@@H](NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)[C@H](C)c1c[nH]c2ccccc12 10.1021/jm960078j
CHEMBL98468 222706 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity towards cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity towards cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL None None None Cc1cccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c1 10.1021/jm00113a023
14208242 163202 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 493 6 1 5 4.0 CCOC(=O)CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00121a004
CHEMBL40668 163202 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 493 6 1 5 4.0 CCOC(=O)CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00121a004
CHEMBL98468 222706 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL None None None Cc1cccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c1 10.1021/jm960509y
CHEMBL103485 215236 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL None None None CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00173a006
CHEMBL319340 217995 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL None None None CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1Cl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00173a006
CHEMBL98468 222706 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL None None None Cc1cccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c1 10.1021/jm00173a006
14208268 211263 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 418 3 2 4 3.5 CN1C(=O)C(NC(=O)c2ccc(Cl)cc2N)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
CHEMBL72428 211263 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 418 3 2 4 3.5 CN1C(=O)C(NC(=O)c2ccc(Cl)cc2N)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
44375675 63280 0 None - 0 Mouse 5.7 pIC50 = 5.7 Binding
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 605 12 4 7 4.9 O=C(O)CN(Cc1ccccc1)S(=O)(=O)c1ccc(N/N=C(/S)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
CHEMBL163506 63280 0 None - 0 Mouse 5.7 pIC50 = 5.7 Binding
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 605 12 4 7 4.9 O=C(O)CN(Cc1ccccc1)S(=O)(=O)c1ccc(N/N=C(/S)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
CHEMBL319340 217995 0 None - 0 Mouse 5.7 pIC50 = 5.7 Binding
Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL None None None CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1Cl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80687-3
15104620 118137 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 476 13 3 2 6.4 CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)Nc1ccc(C)cc1 10.1021/jm00116a002
CHEMBL326979 118137 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 476 13 3 2 6.4 CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)Nc1ccc(C)cc1 10.1021/jm00116a002
14208242 163202 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 493 6 1 5 4.0 CCOC(=O)CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00078a018
CHEMBL40668 163202 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 493 6 1 5 4.0 CCOC(=O)CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00078a018
3960 9124 23 None - 1 Human 5.7 pIC50 = 5.7 Binding
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 458 14 2 3 5.2 CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCCC 10.1021/jm00164a020
891 9124 23 None - 1 Human 5.7 pIC50 = 5.7 Binding
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 458 14 2 3 5.2 CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCCC 10.1021/jm00164a020
CHEMBL24938 9124 23 None - 1 Human 5.7 pIC50 = 5.7 Binding
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 458 14 2 3 5.2 CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCCC 10.1021/jm00164a020
44349434 123793 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 396 11 3 3 3.6 CCC(C)(CC)CCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 10.1021/jm00079a003
CHEMBL338929 123793 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 396 11 3 3 3.6 CCC(C)(CC)CCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 10.1021/jm00079a003
44349087 125227 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 420 7 3 3 3.8 O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NC1CCC2CCCCC2C1 10.1021/jm00079a003
CHEMBL341143 125227 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 420 7 3 3 3.8 O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NC1CCC2CCCCC2C1 10.1021/jm00079a003
44382329 127404 1 None - 0 Mouse 5.7 pIC50 = 5.7 Binding
The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in mouse brain at a pH of 7.4The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in mouse brain at a pH of 7.4
ChEMBL 475 3 2 2 5.9 O=C1NN(C(=S)Nc2ccc(Cl)c(C(F)(F)F)c2)[C@H](c2ccccc2)[C@H]1c1ccccc1 10.1016/S0960-894X(00)80684-8
CHEMBL354633 127404 1 None - 0 Mouse 5.7 pIC50 = 5.7 Binding
The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in mouse brain at a pH of 7.4The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in mouse brain at a pH of 7.4
ChEMBL 475 3 2 2 5.9 O=C1NN(C(=S)Nc2ccc(Cl)c(C(F)(F)F)c2)[C@H](c2ccccc2)[C@H]1c1ccccc1 10.1016/S0960-894X(00)80684-8
14208299 74516 0 None - 0 Human 4.7 pIC50 = 4.7 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 465 3 1 3 4.2 CN1C(=O)[C@@H](NC(=O)c2ccccc2Br)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL1907844 74516 0 None - 0 Human 4.7 pIC50 = 4.7 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 465 3 1 3 4.2 CN1C(=O)[C@@H](NC(=O)c2ccccc2Br)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
14208253 211488 0 None - 0 Human 4.7 pIC50 = 4.7 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 389 3 2 3 3.9 O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1cccc(Cl)c1 10.1021/jm00120a002
CHEMBL74125 211488 0 None - 0 Human 4.7 pIC50 = 4.7 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 389 3 2 3 3.9 O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1cccc(Cl)c1 10.1021/jm00120a002
14991542 113584 0 None - 0 Human 4.7 pIC50 = 4.7 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 893 22 8 8 4.2 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCc1ccc(C(F)(F)F)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL3144545 113584 0 None - 0 Human 4.7 pIC50 = 4.7 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 893 22 8 8 4.2 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCc1ccc(C(F)(F)F)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
44349353 123620 0 None - 0 Rat 4.7 pIC50 = 4.7 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 415 7 3 4 3.0 Cc1cc(C)cc(C(=O)NC(CCC(=O)O)C(=O)NN2CCC3(CCCC3)CC2)c1 10.1021/jm00079a003
CHEMBL338045 123620 0 None - 0 Rat 4.7 pIC50 = 4.7 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 415 7 3 4 3.0 Cc1cc(C)cc(C(=O)NC(CCC(=O)O)C(=O)NN2CCC3(CCCC3)CC2)c1 10.1021/jm00079a003
10530400 126113 0 None - 0 Mouse 6.7 pIC50 = 6.7 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 535 7 3 5 5.0 COC(=O)C1(NC(=O)[C@@](C)(Cc2c[nH]c3ccccc23)NC(=O)OC2C3CC4CC(C3)CC2C4)CCCCC1 10.1021/jm970065l
CHEMBL344220 126113 0 None - 0 Mouse 6.7 pIC50 = 6.7 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 535 7 3 5 5.0 COC(=O)C1(NC(=O)[C@@](C)(Cc2c[nH]c3ccccc23)NC(=O)OC2C3CC4CC(C3)CC2C4)CCCCC1 10.1021/jm970065l
44303669 175068 0 None - 0 Mouse 5.7 pIC50 = 5.7 Binding
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 573 10 4 5 3.9 O=C(O)CCC(=O)N[C@@H](CNC(=O)C1(NC(=O)OC2C3CC4CC(C3)CC2C4)Cc2ccccc2C1)c1ccccc1 10.1016/S0960-894X(97)00356-9
CHEMBL434020 175068 0 None - 0 Mouse 5.7 pIC50 = 5.7 Binding
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 573 10 4 5 3.9 O=C(O)CCC(=O)N[C@@H](CNC(=O)C1(NC(=O)OC2C3CC4CC(C3)CC2C4)Cc2ccccc2C1)c1ccccc1 10.1016/S0960-894X(97)00356-9
10344702 35403 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 471 7 2 5 3.6 COc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CCN(C)C)C2=O)c1 10.1021/jm00078a018
CHEMBL137714 35403 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 471 7 2 5 3.6 COc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CCN(C)C)C2=O)c1 10.1021/jm00078a018
44283085 106682 0 None - 0 Mouse 4.7 pIC50 = 4.7 Binding
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 484 9 2 2 7.4 CC(CCCCc1ccccc1)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
CHEMBL286093 106682 0 None - 0 Mouse 4.7 pIC50 = 4.7 Binding
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 484 9 2 2 7.4 CC(CCCCc1ccccc1)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
44283151 125945 0 None - 0 Mouse 5.7 pIC50 = 5.7 Binding
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 531 9 4 4 5.6 O=C(NC(Cc1c[nH]c2ccccc12)/C(S)=N/C(CO)Cc1ccccc1)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
CHEMBL34300 125945 0 None - 0 Mouse 5.7 pIC50 = 5.7 Binding
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 531 9 4 4 5.6 O=C(NC(Cc1c[nH]c2ccccc12)/C(S)=N/C(CO)Cc1ccccc1)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
44365788 128471 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Compound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transfected with cDNA of human Cholecystokinin type B receptorCompound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transfected with cDNA of human Cholecystokinin type B receptor
ChEMBL 643 7 1 7 5.5 COC(=O)n1c(C(=O)NC2C(=O)N(CC(=O)N(c3ccccc3)C(C)C)c3ccccc3N(c3ccccc3)C2=O)cc2ccccc21 10.1021/jm9601664
CHEMBL358778 128471 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Compound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transfected with cDNA of human Cholecystokinin type B receptorCompound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transfected with cDNA of human Cholecystokinin type B receptor
ChEMBL 643 7 1 7 5.5 COC(=O)n1c(C(=O)NC2C(=O)N(CC(=O)N(c3ccccc3)C(C)C)c3ccccc3N(c3ccccc3)C2=O)cc2ccccc21 10.1021/jm9601664
CHEMBL1172428 215365 0 None -47 3 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2010.05.078
CHEMBL1172429 215366 0 None -120 4 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2010.05.078
CHEMBL2372623 217056 0 None -218 4 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2010.05.078
21842345 128481 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 522 6 2 4 5.9 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3CCCCCC3)C2=O)c1 10.1016/0960-894X(95)00556-9
CHEMBL358875 128481 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 522 6 2 4 5.9 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3CCCCCC3)C2=O)c1 10.1016/0960-894X(95)00556-9
5311201 214174 35 None -27 6 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00121a004
CHEMBL9387 214174 35 None -27 6 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00121a004
5311201 214174 35 None -27 6 Human 8.7 pIC50 = 8.7 Binding
Half maximal inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cerebral cortex.Half maximal inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cerebral cortex.
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm970517u
CHEMBL9387 214174 35 None -27 6 Human 8.7 pIC50 = 8.7 Binding
Half maximal inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cerebral cortex.Half maximal inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cerebral cortex.
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm970517u
5311201 214174 35 None -26 6 Mouse 8.7 pIC50 = 8.7 Binding
Half maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortexHalf maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm000937a
CHEMBL9387 214174 35 None -26 6 Mouse 8.7 pIC50 = 8.7 Binding
Half maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortexHalf maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm000937a
10053201 23364 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 546 6 3 3 5.9 CCc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2c1ccccc1 10.1021/jm00048a015
CHEMBL124004 23364 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 546 6 3 3 5.9 CCc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2c1ccccc1 10.1021/jm00048a015
5311201 214174 35 None -27 6 Human 8.7 pIC50 = 8.7 Binding
Inhibition of Cholecystokinin type B receptor induced guinea pig gall bladder contractions when given intravenouslyInhibition of Cholecystokinin type B receptor induced guinea pig gall bladder contractions when given intravenously
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm020424z
CHEMBL9387 214174 35 None -27 6 Human 8.7 pIC50 = 8.7 Binding
Inhibition of Cholecystokinin type B receptor induced guinea pig gall bladder contractions when given intravenouslyInhibition of Cholecystokinin type B receptor induced guinea pig gall bladder contractions when given intravenously
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm020424z
CHEMBL274661 217594 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranesInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranes
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)OCCc1ccccc1 10.1021/jm00072a024
CHEMBL274661 217594 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat TcellsInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat Tcells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)OCCc1ccccc1 10.1021/jm00072a024
44293811 191898 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesInhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranes
ChEMBL 601 5 2 4 5.8 Cc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(Cl)c1)N=C2c1ccccc1F 10.1016/S0960-894X(96)00609-9
CHEMBL48563 191898 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesInhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranes
ChEMBL 601 5 2 4 5.8 Cc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(Cl)c1)N=C2c1ccccc1F 10.1016/S0960-894X(96)00609-9
5311201 214174 35 None -27 6 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesInhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranes
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00609-9
CHEMBL9387 214174 35 None -27 6 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesInhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranes
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00609-9
5311201 214174 35 None -27 6 Human 8.7 pIC50 = 8.7 Binding
Inhibition of cholecystokinin B receptorInhibition of cholecystokinin B receptor
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/np9800102
CHEMBL9387 214174 35 None -27 6 Human 8.7 pIC50 = 8.7 Binding
Inhibition of cholecystokinin B receptorInhibition of cholecystokinin B receptor
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/np9800102
5311201 214174 35 None -27 6 Human 8.7 pIC50 = 8.7 Binding
The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain at a pH of 6.5The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain at a pH of 6.5
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(00)80684-8
CHEMBL9387 214174 35 None -27 6 Human 8.7 pIC50 = 8.7 Binding
The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain at a pH of 6.5The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain at a pH of 6.5
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(00)80684-8
145979415 173338 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting methodDisplacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting method
ChEMBL 509 6 3 6 4.9 CCOc1ccc(-n2c(NNC(=S)Nc3ccc(Br)cc3)nc3ccccc3c2=O)cc1 10.1039/C7MD00171A
CHEMBL4279660 173338 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting methodDisplacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting method
ChEMBL 509 6 3 6 4.9 CCOc1ccc(-n2c(NNC(=S)Nc3ccc(Br)cc3)nc3ccccc3c2=O)cc1 10.1039/C7MD00171A
155526914 177981 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1837 72 19 24 0.8 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4459331 177981 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1837 72 19 24 0.8 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
21842327 52817 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 468 6 2 4 4.6 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)C)C2=O)c1 10.1016/0960-894X(95)00556-9
CHEMBL153308 52817 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 468 6 2 4 4.6 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)C)C2=O)c1 10.1016/0960-894X(95)00556-9
155532425 178527 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1822 71 18 23 2.5 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)[C@@H](C)CC 10.1021/acs.jmedchem.8b01558
CHEMBL4467338 178527 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1822 71 18 23 2.5 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)[C@@H](C)CC 10.1021/acs.jmedchem.8b01558
CHEMBL407057 219414 0 None 120 4 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O 10.1021/jm050921q
10369804 23532 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 532 5 3 3 5.6 Cc1cccc2c1N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2c1ccccc1 10.1021/jm00048a015
CHEMBL124340 23532 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 532 5 3 3 5.6 Cc1cccc2c1N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2c1ccccc1 10.1021/jm00048a015
44349572 121837 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 533 5 2 4 6.0 Cc1ccc2c(c1)N(CC(=O)OC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2c1ccccc1 10.1021/jm00048a015
CHEMBL334305 121837 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 533 5 2 4 6.0 Cc1ccc2c(c1)N(CC(=O)OC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2c1ccccc1 10.1021/jm00048a015
10431936 100013 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 414 4 2 4 3.7 COc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
CHEMBL2448131 100013 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 414 4 2 4 3.7 COc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
CHEMBL384035 219095 4 None -512 4 Rat 8.6 pIC50 = 8.6 Binding
In vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic aciniIn vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic acini
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80679-4
CHEMBL428666 219095 4 None -512 4 Rat 8.6 pIC50 = 8.6 Binding
In vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic aciniIn vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic acini
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80679-4
CHEMBL384035 219095 4 None -512 4 Rat 8.6 pIC50 = 8.6 Binding
Inhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic aciniInhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic acini
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00072a024
CHEMBL428666 219095 4 None -512 4 Rat 8.6 pIC50 = 8.6 Binding
Inhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic aciniInhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic acini
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00072a024
44332065 116492 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL 552 13 3 4 4.3 CCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N(CCC1CCCCC1)CC(=O)N1CCC[C@H]1C(=O)O 10.1016/S0960-894X(96)00546-X
CHEMBL322893 116492 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL 552 13 3 4 4.3 CCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N(CCC1CCCCC1)CC(=O)N1CCC[C@H]1C(=O)O 10.1016/S0960-894X(96)00546-X
44327450 174980 0 None - 0 Mouse 8.6 pIC50 = 8.6 Binding
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 558 10 3 5 4.6 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccn1)CC(=O)O 10.1016/S0960-894X(01)80769-1
CHEMBL433384 174980 0 None - 0 Mouse 8.6 pIC50 = 8.6 Binding
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 558 10 3 5 4.6 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccn1)CC(=O)O 10.1016/S0960-894X(01)80769-1
21842336 128296 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 480 6 2 4 4.7 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3CCC3)C2=O)c1 10.1016/0960-894X(95)00556-9
CHEMBL358420 128296 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 480 6 2 4 4.7 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3CCC3)C2=O)c1 10.1016/0960-894X(95)00556-9
11799907 103774 0 None - 0 Mouse 8.6 pIC50 = 8.6 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 511 6 3 7 5.0 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2ccc(Cl)c(Cl)c2)c1 10.1021/jm970373j
CHEMBL266557 103774 0 None - 0 Mouse 8.6 pIC50 = 8.6 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 511 6 3 7 5.0 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2ccc(Cl)c(Cl)c2)c1 10.1021/jm970373j
CHEMBL1806531 215755 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]CCK from gastrin receptor isolated from human tumor tissuesDisplacement of [125I]CCK from gastrin receptor isolated from human tumor tissues
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm101279a
CHEMBL1806532 215756 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]CCK from gastrin receptor isolated from human tumor tissuesDisplacement of [125I]CCK from gastrin receptor isolated from human tumor tissues
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm101279a
71458004 85403 0 None - 0 Mouse 8.6 pIC50 = 8.6 Binding
Evaluated for inhibition of CCK-B receptor by displacing [125I]bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of CCK-B receptor by displacing [125I]bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 670 12 5 8 4.7 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCn1nn[nH]c1=S)c1ccccc1 10.1021/jm00092a007
CHEMBL2112335 85403 0 None - 0 Mouse 8.6 pIC50 = 8.6 Binding
Evaluated for inhibition of CCK-B receptor by displacing [125I]bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of CCK-B receptor by displacing [125I]bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 670 12 5 8 4.7 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCn1nn[nH]c1=S)c1ccccc1 10.1021/jm00092a007
44318205 212573 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 459 3 3 4 3.9 CN1C(=O)[C@H](NC(=O)Nc2ccc3c(c2)CCC3)N=C([C@H]2CC(C)(C)CCN2)c2ccccc21 10.1021/jm9608523
CHEMBL83130 212573 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 459 3 3 4 3.9 CN1C(=O)[C@H](NC(=O)Nc2ccc3c(c2)CCC3)N=C([C@H]2CC(C)(C)CCN2)c2ccccc21 10.1021/jm9608523
CHEMBL120632 215384 33 None - 3 Mouse 8.6 pIC50 = 8.6 Binding
Concentration producing half-maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortexConcentration producing half-maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL None None None CSCC[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/0960-894X(94)85022-4
56663263 70792 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]CCK from gastrin receptor isolated from human tumor tissuesDisplacement of [125I]CCK from gastrin receptor isolated from human tumor tissues
ChEMBL 1538 51 14 25 -2.8 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NCCOCCOCCOCCOCCOCCOC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm101279a
CHEMBL1807150 70792 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]CCK from gastrin receptor isolated from human tumor tissuesDisplacement of [125I]CCK from gastrin receptor isolated from human tumor tissues
ChEMBL 1538 51 14 25 -2.8 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NCCOCCOCCOCCOCCOCCOC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm101279a
71454457 85398 0 None - 0 Mouse 8.6 pIC50 = 8.6 Binding
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 655 12 5 7 4.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CSc1nc[nH]n1)c1ccccc1 10.1021/jm00092a007
CHEMBL2112330 85398 0 None - 0 Mouse 8.6 pIC50 = 8.6 Binding
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 655 12 5 7 4.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CSc1nc[nH]n1)c1ccccc1 10.1021/jm00092a007
10458620 121324 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 499 5 2 4 5.4 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)c3ccccc3N(CC(=O)OC(C)(C)C)C2=O)c1 10.1021/jm00048a015
CHEMBL333718 121324 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 499 5 2 4 5.4 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)c3ccccc3N(CC(=O)OC(C)(C)C)C2=O)c1 10.1021/jm00048a015
10625474 35999 0 None - 0 Mouse 8.6 pIC50 = 8.6 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 508 8 3 5 4.2 COC[C@H]1CCCN1NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1021/jm970065l
CHEMBL138233 35999 0 None - 0 Mouse 8.6 pIC50 = 8.6 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 508 8 3 5 4.2 COC[C@H]1CCCN1NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1021/jm970065l
CHEMBL5273681 200551 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity to human CCK2R expressed in human A-431 cellsBinding affinity to human CCK2R expressed in human A-431 cells
ChEMBL 1219 24 15 16 -0.0 CSCCC[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CCCCNC(=O)[C@H](NC(=O)c2ccc(NN)nc2)CCC(=O)N[C@@H](C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.ejmech.2021.113538
10392653 125819 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 544 5 2 5 3.4 CN1CCN(C(=O)CN2C(=O)C(NC(=O)Nc3ccc(Cl)cc3)N=C(c3ccccc3)c3ccccc32)CC1 10.1016/S0960-894X(00)80683-6
CHEMBL342640 125819 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 544 5 2 5 3.4 CN1CCN(C(=O)CN2C(=O)C(NC(=O)Nc3ccc(Cl)cc3)N=C(c3ccccc3)c3ccccc32)CC1 10.1016/S0960-894X(00)80683-6
71449079 85402 0 None - 0 Mouse 8.6 pIC50 = 8.6 Binding
Evaluated for inhibition of CCK-B receptor by displacing [125I]bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of CCK-B receptor by displacing [125I]bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 639 11 5 7 4.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)Cc1cc(O)no1)c1ccccc1 10.1021/jm00092a007
CHEMBL2112334 85402 0 None - 0 Mouse 8.6 pIC50 = 8.6 Binding
Evaluated for inhibition of CCK-B receptor by displacing [125I]bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of CCK-B receptor by displacing [125I]bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 639 11 5 7 4.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)Cc1cc(O)no1)c1ccccc1 10.1021/jm00092a007
14802530 28389 0 None - 0 Mouse 8.6 pIC50 = 8.6 Binding
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 614 12 5 5 4.3 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](CNC(=O)CC(=O)O)Cc1ccccc1 10.1021/jm00105a062
CHEMBL131754 28389 0 None - 0 Mouse 8.6 pIC50 = 8.6 Binding
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 614 12 5 5 4.3 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](CNC(=O)CC(=O)O)Cc1ccccc1 10.1021/jm00105a062
CHEMBL205965 215948 0 None 31 3 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
44300744 108730 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 542 6 4 4 4.7 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)O)c1)C[C@@H]2c1ccccc1 10.1016/0960-894X(95)00327-P
CHEMBL301261 108730 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 542 6 4 4 4.7 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)O)c1)C[C@@H]2c1ccccc1 10.1016/0960-894X(95)00327-P
10003805 114241 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Compound was tested for its binding affinity against gastrin receptor in guinea pig gastric glandsCompound was tested for its binding affinity against gastrin receptor in guinea pig gastric glands
ChEMBL 448 4 2 5 2.9 CCCN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C(N2CCN(C)CC2)c2ccccc21 10.1016/0960-894X(95)00530-0
CHEMBL318360 114241 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Compound was tested for its binding affinity against gastrin receptor in guinea pig gastric glandsCompound was tested for its binding affinity against gastrin receptor in guinea pig gastric glands
ChEMBL 448 4 2 5 2.9 CCCN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C(N2CCN(C)CC2)c2ccccc21 10.1016/0960-894X(95)00530-0
51353551 24906 16 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]BDZ2 from CCK2R (unknown origin) expressed in CHO cellsDisplacement of [125I]BDZ2 from CCK2R (unknown origin) expressed in CHO cells
ChEMBL 605 8 3 5 5.0 CC(C)N(C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(C(=O)O)c2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1016/j.bmcl.2015.03.051
CHEMBL1269257 24906 16 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]BDZ2 from CCK2R (unknown origin) expressed in CHO cellsDisplacement of [125I]BDZ2 from CCK2R (unknown origin) expressed in CHO cells
ChEMBL 605 8 3 5 5.0 CC(C)N(C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(C(=O)O)c2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1016/j.bmcl.2015.03.051
19018662 33285 14 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 424 3 2 3 4.1 CN1C(=O)C(NC(=O)Nc2ccc3c(c2)CCC3)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL136038 33285 14 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 424 3 2 3 4.1 CN1C(=O)C(NC(=O)Nc2ccc3c(c2)CCC3)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL2369762 216459 0 None - 0 Mouse 8.6 pIC50 = 8.6 Binding
Concentration producing half-maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortexConcentration producing half-maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL None None None CCCCC[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/0960-894X(94)85022-4
5311201 214174 35 None -27 6 Human 8.5 pIC50 = 8.5 Binding
Inhibition of [125I]-labeled gastrin binding to gastrin receptor in guinea pig brain membranesInhibition of [125I]-labeled gastrin binding to gastrin receptor in guinea pig brain membranes
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00108a040
CHEMBL9387 214174 35 None -27 6 Human 8.5 pIC50 = 8.5 Binding
Inhibition of [125I]-labeled gastrin binding to gastrin receptor in guinea pig brain membranesInhibition of [125I]-labeled gastrin binding to gastrin receptor in guinea pig brain membranes
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00108a040
10815094 127177 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesInhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranes
ChEMBL 495 5 3 7 3.2 Cc1ccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc1N(C)c1nn[nH]n1 10.1021/jm9506736
CHEMBL353509 127177 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesInhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranes
ChEMBL 495 5 3 7 3.2 Cc1ccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc1N(C)c1nn[nH]n1 10.1021/jm9506736
44280599 105938 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 694 12 4 5 6.2 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2ccccc12 10.1021/jm950372w
CHEMBL281206 105938 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 694 12 4 5 6.2 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2ccccc12 10.1021/jm950372w
44336539 11916 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]BDZ1 from CCK2R (unknown origin) expressed in CHO cellsDisplacement of [125I]BDZ1 from CCK2R (unknown origin) expressed in CHO cells
ChEMBL 563 7 2 5 4.6 COc1ccc(N(C)C(=O)CN2C(=O)C(NC(=O)Nc3ccccc3)C(=O)N(c3ccccc3)c3ccccc32)cc1 10.1016/j.bmcl.2015.03.051
CHEMBL105775 11916 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]BDZ1 from CCK2R (unknown origin) expressed in CHO cellsDisplacement of [125I]BDZ1 from CCK2R (unknown origin) expressed in CHO cells
ChEMBL 563 7 2 5 4.6 COc1ccc(N(C)C(=O)CN2C(=O)C(NC(=O)Nc3ccccc3)C(=O)N(c3ccccc3)c3ccccc32)cc1 10.1016/j.bmcl.2015.03.051
155536224 178938 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter methodDisplacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter method
ChEMBL 1409 38 15 21 -2.1 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)n1cc([C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)nn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.9b01936
CHEMBL4473301 178938 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter methodDisplacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter method
ChEMBL 1409 38 15 21 -2.1 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)n1cc([C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)nn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.9b01936
10501974 103750 0 None - 0 Mouse 6.7 pIC50 = 6.7 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 415 5 3 6 3.9 COc1cccc(-n2c(NNC(=O)Nc3cccc(C)c3)nc3ccccc3c2=O)c1 10.1021/jm970373j
CHEMBL266376 103750 0 None - 0 Mouse 6.7 pIC50 = 6.7 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 415 5 3 6 3.9 COc1cccc(-n2c(NNC(=O)Nc3cccc(C)c3)nc3ccccc3c2=O)c1 10.1021/jm970373j
CHEMBL411202 219652 0 None - 0 Bovine 6.7 pIC50 = 6.7 Binding
Concentration inhibiting [3H]propionyl-CCK-8 binding to cholecystokinin type B receptor of bovine striatum.Concentration inhibiting [3H]propionyl-CCK-8 binding to cholecystokinin type B receptor of bovine striatum.
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00100a033
44349069 124837 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Concentration required to inhibit by 50% the specific binding of [3H]pentagastrin to CCK-B in rabbit gastric glandConcentration required to inhibit by 50% the specific binding of [3H]pentagastrin to CCK-B in rabbit gastric gland
ChEMBL 455 7 3 4 3.6 O=C(O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)NN1CCC2(CCCC2)CC1 10.1021/jm00079a003
CHEMBL340413 124837 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Concentration required to inhibit by 50% the specific binding of [3H]pentagastrin to CCK-B in rabbit gastric glandConcentration required to inhibit by 50% the specific binding of [3H]pentagastrin to CCK-B in rabbit gastric gland
ChEMBL 455 7 3 4 3.6 O=C(O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)NN1CCC2(CCCC2)CC1 10.1021/jm00079a003
73351327 89200 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranesInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranes
ChEMBL 1019 29 9 11 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCOc1ccccc1)CC(=O)O 10.1021/jm00072a024
CHEMBL217424 89200 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranesInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranes
ChEMBL 1019 29 9 11 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCOc1ccccc1)CC(=O)O 10.1021/jm00072a024
14888714 84024 0 None - 0 Bovine 6.7 pIC50 = 6.7 Binding
Inhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranesInhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranes
ChEMBL 1067 30 11 12 0.9 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@@H](Cc1ccc(C(F)(F)C(=O)O)cc1)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00107a037
CHEMBL2079602 84024 0 None - 0 Bovine 6.7 pIC50 = 6.7 Binding
Inhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranesInhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranes
ChEMBL 1067 30 11 12 0.9 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@@H](Cc1ccc(C(F)(F)C(=O)O)cc1)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00107a037
44303298 210080 0 None - 0 Mouse 6.7 pIC50 = 6.7 Binding
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 522 9 5 6 3.5 CC(Cc1ccc(O)cc1)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CO)[C@H](O)c1ccccc1 10.1016/S0960-894X(97)00356-9
CHEMBL64770 210080 0 None - 0 Mouse 6.7 pIC50 = 6.7 Binding
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 522 9 5 6 3.5 CC(Cc1ccc(O)cc1)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CO)[C@H](O)c1ccccc1 10.1016/S0960-894X(97)00356-9
14991572 169959 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 848 20 8 9 3.4 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1cnc2ccccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL418123 169959 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 848 20 8 9 3.4 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1cnc2ccccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
44348808 24707 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 451 7 3 4 3.9 O=C(O)CCC(NC(=O)c1ccc2ccccc2c1)C(=O)NN1CCC2(CCCCC2)CC1 10.1021/jm00079a003
CHEMBL125925 24707 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 451 7 3 4 3.9 O=C(O)CCC(NC(=O)c1ccc2ccccc2c1)C(=O)NN1CCC2(CCCCC2)CC1 10.1021/jm00079a003
44280996 106520 0 None - 1 Mouse 6.7 pIC50 = 6.7 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 745 14 4 8 5.4 CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
CHEMBL284976 106520 0 None - 1 Mouse 6.7 pIC50 = 6.7 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 745 14 4 8 5.4 CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
44279861 109961 0 None - 1 Mouse 6.7 pIC50 = 6.7 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 726 14 6 9 3.1 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCC(=O)NCCSCc3csc(N=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
CHEMBL30821 109961 0 None - 1 Mouse 6.7 pIC50 = 6.7 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 726 14 6 9 3.1 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCC(=O)NCCSCc3csc(N=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
44280373 106164 0 None - 1 Human 6.7 pIC50 = 6.7 Binding
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 773 16 4 8 5.4 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL282646 106164 0 None - 1 Human 6.7 pIC50 = 6.7 Binding
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 773 16 4 8 5.4 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
155523323 177567 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter methodDisplacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter method
ChEMBL 1409 38 16 20 -2.1 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)c1c[nH]nn1 10.1021/acs.jmedchem.9b01936
CHEMBL4453047 177567 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter methodDisplacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter method
ChEMBL 1409 38 16 20 -2.1 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)c1c[nH]nn1 10.1021/acs.jmedchem.9b01936
CHEMBL3142681 217905 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL None None None Cc1ccccc1NC(=O)NCCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
CHEMBL3142698 217913 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity towards cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity towards cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL None None None Cc1ccccc1/N=C(/S)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
44349314 23339 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Concentration required to inhibit by 50% the specific binding of [3H]pentagastrin to Cholecystokinin type B receptor in rabbit gastric glandConcentration required to inhibit by 50% the specific binding of [3H]pentagastrin to Cholecystokinin type B receptor in rabbit gastric gland
ChEMBL 402 8 3 3 3.5 CC(C)(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1cc(Cl)cc(Cl)c1 10.1021/jm00079a003
CHEMBL123852 23339 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Concentration required to inhibit by 50% the specific binding of [3H]pentagastrin to Cholecystokinin type B receptor in rabbit gastric glandConcentration required to inhibit by 50% the specific binding of [3H]pentagastrin to Cholecystokinin type B receptor in rabbit gastric gland
ChEMBL 402 8 3 3 3.5 CC(C)(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1cc(Cl)cc(Cl)c1 10.1021/jm00079a003
44458120 105737 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [125I]CCK-OP radioligand from Cholecystokinin type B receptor of guinea pig cortical membranesDisplacement of [125I]CCK-OP radioligand from Cholecystokinin type B receptor of guinea pig cortical membranes
ChEMBL 377 5 3 3 2.0 O=C(N[C@@H]1C(=O)N(Cc2ccccc2)C[C@@H]1C(=O)O)c1cc2ccccc2[nH]1 10.1016/S0960-894X(00)80224-3
CHEMBL279730 105737 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [125I]CCK-OP radioligand from Cholecystokinin type B receptor of guinea pig cortical membranesDisplacement of [125I]CCK-OP radioligand from Cholecystokinin type B receptor of guinea pig cortical membranes
ChEMBL 377 5 3 3 2.0 O=C(N[C@@H]1C(=O)N(Cc2ccccc2)C[C@@H]1C(=O)O)c1cc2ccccc2[nH]1 10.1016/S0960-894X(00)80224-3
14208305 74518 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 513 3 1 3 4.0 CN1C(=O)[C@H](NC(=O)c2cccc(I)c2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL1907846 74518 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 513 3 1 3 4.0 CN1C(=O)[C@H](NC(=O)c2cccc(I)c2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
14208231 211025 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 422 3 1 4 3.7 CN1C(=O)C(NC(=O)c2cc3ccccc3n2C)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
CHEMBL71079 211025 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 422 3 1 4 3.7 CN1C(=O)C(NC(=O)c2cc3ccccc3n2C)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
14444022 113451 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
In vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 692 17 7 7 2.7 CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(=O)O)CC(=O)N[C@H](Cc1ccccc1)C(N)=O 10.1021/jm00123a003
CHEMBL3143385 113451 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
In vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 692 17 7 7 2.7 CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(=O)O)CC(=O)N[C@H](Cc1ccccc1)C(N)=O 10.1021/jm00123a003
44365965 128478 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
In vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 649 16 6 6 3.8 CC(C)CC(CC(=O)N[C@H](CC(=O)O)C(=O)NCCc1ccccc1)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00123a003
CHEMBL358826 128478 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
In vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 649 16 6 6 3.8 CC(C)CC(CC(=O)N[C@H](CC(=O)O)C(=O)NCCc1ccccc1)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00123a003
44334258 11236 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 451 8 3 4 3.5 Cc1cccc(NC(=O)N[C@H](CCC(=O)O)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
CHEMBL101752 11236 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 451 8 3 4 3.5 Cc1cccc(NC(=O)N[C@H](CCC(=O)O)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
44334172 11341 1 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 556 10 3 5 4.9 Cc1cccc(NC(=O)N[C@H](CCC(=O)OCc2ccccc2)C(=O)N2CCC(C(=O)Nc3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
CHEMBL102526 11341 1 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 556 10 3 5 4.9 Cc1cccc(NC(=O)N[C@H](CCC(=O)OCc2ccccc2)C(=O)N2CCC(C(=O)Nc3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
14208231 211025 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Tested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pigTested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pig
ChEMBL 422 3 1 4 3.7 CN1C(=O)C(NC(=O)c2cc3ccccc3n2C)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80682-4
CHEMBL71079 211025 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Tested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pigTested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pig
ChEMBL 422 3 1 4 3.7 CN1C(=O)C(NC(=O)c2cc3ccccc3n2C)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80682-4
14208230 109986 0 None - 0 Human 4.7 pIC50 = 4.7 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 446 3 3 3 4.5 O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1cc2cc(Cl)ccc2[nH]1 10.1021/jm00120a002
CHEMBL308414 109986 0 None - 0 Human 4.7 pIC50 = 4.7 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 446 3 3 3 4.5 O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1cc2cc(Cl)ccc2[nH]1 10.1021/jm00120a002
44365993 50958 0 None - 0 Human 4.7 pIC50 = 4.7 Binding
In vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 635 15 6 6 3.8 CC(C)C[C@@H](CC(=O)NC(CC(=O)O)C(=O)NCc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00123a003
CHEMBL151619 50958 0 None - 0 Human 4.7 pIC50 = 4.7 Binding
In vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 635 15 6 6 3.8 CC(C)C[C@@H](CC(=O)NC(CC(=O)O)C(=O)NCc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00123a003
15104613 117092 0 None - 0 Human 4.7 pIC50 = 4.7 Binding
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 486 13 3 2 6.2 CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1c[nH]c2ccccc12 10.1021/jm00116a002
CHEMBL323854 117092 0 None - 0 Human 4.7 pIC50 = 4.7 Binding
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 486 13 3 2 6.2 CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1c[nH]c2ccccc12 10.1021/jm00116a002
10076650 33004 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Displacement of [3H]propionylCCK8 from rat cerebral cortex CCK2Displacement of [3H]propionylCCK8 from rat cerebral cortex CCK2
ChEMBL 566 8 4 5 3.5 O=C(N[C@@H]1C[C@H]2c3[nH]c4ccccc4c3C[C@H](C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N2C1=O)OCc1ccccc1 10.1021/jm050689o
CHEMBL13577 33004 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Displacement of [3H]propionylCCK8 from rat cerebral cortex CCK2Displacement of [3H]propionylCCK8 from rat cerebral cortex CCK2
ChEMBL 566 8 4 5 3.5 O=C(N[C@@H]1C[C@H]2c3[nH]c4ccccc4c3C[C@H](C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N2C1=O)OCc1ccccc1 10.1021/jm050689o
10076650 33004 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro inhibition of [3H]propionyl-CCK-8 binding to rat cerebral cortex membranes at Cholecystokinin type B receptor.In vitro inhibition of [3H]propionyl-CCK-8 binding to rat cerebral cortex membranes at Cholecystokinin type B receptor.
ChEMBL 566 8 4 5 3.5 O=C(N[C@@H]1C[C@H]2c3[nH]c4ccccc4c3C[C@H](C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N2C1=O)OCc1ccccc1 10.1021/jm000959x
CHEMBL13577 33004 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro inhibition of [3H]propionyl-CCK-8 binding to rat cerebral cortex membranes at Cholecystokinin type B receptor.In vitro inhibition of [3H]propionyl-CCK-8 binding to rat cerebral cortex membranes at Cholecystokinin type B receptor.
ChEMBL 566 8 4 5 3.5 O=C(N[C@@H]1C[C@H]2c3[nH]c4ccccc4c3C[C@H](C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N2C1=O)OCc1ccccc1 10.1021/jm000959x
10076650 33004 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Inhibition of [3H]propionyl-CCK-8 specific binding to rat cerebral cortex membranes Cholecystokinin type B receptorInhibition of [3H]propionyl-CCK-8 specific binding to rat cerebral cortex membranes Cholecystokinin type B receptor
ChEMBL 566 8 4 5 3.5 O=C(N[C@@H]1C[C@H]2c3[nH]c4ccccc4c3C[C@H](C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N2C1=O)OCc1ccccc1 10.1016/s0960-894x(01)00630-8
CHEMBL13577 33004 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Inhibition of [3H]propionyl-CCK-8 specific binding to rat cerebral cortex membranes Cholecystokinin type B receptorInhibition of [3H]propionyl-CCK-8 specific binding to rat cerebral cortex membranes Cholecystokinin type B receptor
ChEMBL 566 8 4 5 3.5 O=C(N[C@@H]1C[C@H]2c3[nH]c4ccccc4c3C[C@H](C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N2C1=O)OCc1ccccc1 10.1016/s0960-894x(01)00630-8
44329486 119376 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 544 6 3 3 5.7 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)C[C@H](c3ccc(F)cc3)N(CC(=O)NC(C)(C)C)C2=O)c1 10.1016/S0960-894X(01)80832-5
CHEMBL330197 119376 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 544 6 3 3 5.7 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)C[C@H](c3ccc(F)cc3)N(CC(=O)NC(C)(C)C)C2=O)c1 10.1016/S0960-894X(01)80832-5
44303651 207260 0 None - 0 Mouse 4.7 pIC50 = 4.7 Binding
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 458 6 2 3 4.4 O=C(NC1(C(=O)NCCc2ccccc2)Cc2ccccc2C1)OC1C2CC3CC(C2)CC1C3 10.1016/S0960-894X(97)00356-9
CHEMBL59859 207260 0 None - 0 Mouse 4.7 pIC50 = 4.7 Binding
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 458 6 2 3 4.4 O=C(NC1(C(=O)NCCc2ccccc2)Cc2ccccc2C1)OC1C2CC3CC(C2)CC1C3 10.1016/S0960-894X(97)00356-9
155562281 182620 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1900 71 16 23 4.4 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1cccc2ccccc12)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4585323 182620 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1900 71 16 23 4.4 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1cccc2ccccc12)C(N)=O 10.1021/acs.jmedchem.8b01558
73351326 89158 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranesInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranes
ChEMBL 1017 29 9 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCCc1ccccc1)CC(=O)O 10.1021/jm00072a024
CHEMBL217234 89158 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranesInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranes
ChEMBL 1017 29 9 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCCc1ccccc1)CC(=O)O 10.1021/jm00072a024
44279810 110621 0 None - 1 Mouse 6.7 pIC50 = 6.7 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 757 16 4 7 5.7 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
CHEMBL30917 110621 0 None - 1 Mouse 6.7 pIC50 = 6.7 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 757 16 4 7 5.7 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
52949124 7663 4 None 2 2 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I-CCK] from human CCK2R V3.28T, S3.29T mutant expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-CCK] from human CCK2R V3.28T, S3.29T mutant expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
9055 7663 4 None 2 2 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I-CCK] from human CCK2R V3.28T, S3.29T mutant expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-CCK] from human CCK2R V3.28T, S3.29T mutant expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
CHEMBL1269258 7663 4 None 2 2 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I-CCK] from human CCK2R V3.28T, S3.29T mutant expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-CCK] from human CCK2R V3.28T, S3.29T mutant expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
DB12694 7663 4 None 2 2 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I-CCK] from human CCK2R V3.28T, S3.29T mutant expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-CCK] from human CCK2R V3.28T, S3.29T mutant expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
44353183 123554 0 None - 0 Mouse 5.7 pIC50 = 5.7 Binding
Evaluated for in vitro binding affinity towards cholecystokinin-B (CCK-B) receptor in mouse cerebral cortex using [125I]bolton hunter CCK-26-33 as radioligand; 1790-2700Evaluated for in vitro binding affinity towards cholecystokinin-B (CCK-B) receptor in mouse cerebral cortex using [125I]bolton hunter CCK-26-33 as radioligand; 1790-2700
ChEMBL 555 8 3 4 5.2 O=C(OC1C2CC3CC(C2)CC1C3)N1CCCC1(Cc1c[nH]c2ccccc12)C(=O)NC(CO)Cc1ccccc1 10.1016/S0960-894X(00)80156-0
CHEMBL337692 123554 0 None - 0 Mouse 5.7 pIC50 = 5.7 Binding
Evaluated for in vitro binding affinity towards cholecystokinin-B (CCK-B) receptor in mouse cerebral cortex using [125I]bolton hunter CCK-26-33 as radioligand; 1790-2700Evaluated for in vitro binding affinity towards cholecystokinin-B (CCK-B) receptor in mouse cerebral cortex using [125I]bolton hunter CCK-26-33 as radioligand; 1790-2700
ChEMBL 555 8 3 4 5.2 O=C(OC1C2CC3CC(C2)CC1C3)N1CCCC1(Cc1c[nH]c2ccccc12)C(=O)NC(CO)Cc1ccccc1 10.1016/S0960-894X(00)80156-0
44349411 23615 0 None - 0 Rat 4.7 pIC50 = 4.7 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 380 7 3 3 3.1 O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NC1CCCCCC1 10.1021/jm00079a003
CHEMBL124802 23615 0 None - 0 Rat 4.7 pIC50 = 4.7 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 380 7 3 3 3.1 O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NC1CCCCCC1 10.1021/jm00079a003
73354295 112723 0 None - 0 Mouse 7.7 pIC50 = 7.7 Binding
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 643 13 5 6 4.5 CONC(=O)CCC(=O)N[C@H](CNC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3)c1ccccc1 10.1021/jm00092a007
CHEMBL312894 112723 0 None - 0 Mouse 7.7 pIC50 = 7.7 Binding
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 643 13 5 6 4.5 CONC(=O)CCC(=O)N[C@H](CNC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3)c1ccccc1 10.1021/jm00092a007
10256428 126466 0 None - 0 Mouse 7.7 pIC50 = 7.7 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 529 9 4 4 4.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC12C[C@H]3C[C@@H](C1)C[C@@H](C2)C3)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
CHEMBL347278 126466 0 None - 0 Mouse 7.7 pIC50 = 7.7 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 529 9 4 4 4.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC12C[C@H]3C[C@@H](C1)C[C@@H](C2)C3)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
CHEMBL386811 219172 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat TcellsInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat Tcells
ChEMBL None None None CCCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)OCCc1ccccc1 10.1021/jm00072a024
44368329 127781 0 None - 0 Mouse 6.7 pIC50 = 6.7 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 499 8 3 3 5.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC12C[C@H]3C[C@@H](C1)C[C@@H](C2)C3)C(=O)NCCc1ccccc1 10.1021/jm00057a005
CHEMBL356446 127781 0 None - 0 Mouse 6.7 pIC50 = 6.7 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 499 8 3 3 5.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC12C[C@H]3C[C@@H](C1)C[C@@H](C2)C3)C(=O)NCCc1ccccc1 10.1021/jm00057a005
90663976 113576 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 839 21 9 9 3.0 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccccc1O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL3144538 113576 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 839 21 9 9 3.0 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccccc1O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
44280224 111561 0 None - 1 Human 6.7 pIC50 = 6.7 Binding
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 757 16 4 7 5.8 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL31090 111561 0 None - 1 Human 6.7 pIC50 = 6.7 Binding
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 757 16 4 7 5.8 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL3142682 217906 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL None None None CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)NC1CCCCC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
14991574 107479 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 836 20 9 8 3.3 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1cc2ccccc2[nH]1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL292471 107479 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 836 20 9 8 3.3 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1cc2ccccc2[nH]1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
90663992 113598 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 866 22 8 9 3.3 CN(C)c1ccc(/C=C\C(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 10.1021/jm00089a010
CHEMBL3144561 113598 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 866 22 8 9 3.3 CN(C)c1ccc(/C=C\C(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 10.1021/jm00089a010
44280130 168058 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 670 11 3 5 5.0 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCc2ccccc21 10.1021/jm950372w
CHEMBL412108 168058 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 670 11 3 5 5.0 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCc2ccccc21 10.1021/jm950372w
11797585 105232 0 None - 0 Mouse 5.7 pIC50 = 5.7 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 445 6 3 7 3.9 COc1ccc(-n2c(NNC(=O)Nc3cccc(C)c3)nc3ccccc3c2=O)cc1OC 10.1021/jm970373j
CHEMBL275789 105232 0 None - 0 Mouse 5.7 pIC50 = 5.7 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 445 6 3 7 3.9 COc1ccc(-n2c(NNC(=O)Nc3cccc(C)c3)nc3ccccc3c2=O)cc1OC 10.1021/jm970373j
10322621 64332 0 None - 0 Mouse 6.7 pIC50 = 6.7 Binding
Inhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 473 7 2 7 4.4 CC(C)Oc1cccc(-n2c(CNC(=O)Nc3ccc([N+](=O)[O-])cc3)nc3ccccc3c2=O)c1 10.1016/S0960-894X(97)00108-X
CHEMBL166443 64332 0 None - 0 Mouse 6.7 pIC50 = 6.7 Binding
Inhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 473 7 2 7 4.4 CC(C)Oc1cccc(-n2c(CNC(=O)Nc3ccc([N+](=O)[O-])cc3)nc3ccccc3c2=O)c1 10.1016/S0960-894X(97)00108-X
44280398 106021 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 601 10 2 4 5.2 CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(Cc1ccccc1)C(=O)O 10.1021/jm950372w
CHEMBL281728 106021 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 601 10 2 4 5.2 CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(Cc1ccccc1)C(=O)O 10.1021/jm950372w
44280101 106369 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 573 9 3 4 5.3 O=C(O)Cc1cccc(NC(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCC3)CC2)c1 10.1021/jm950372w
CHEMBL283920 106369 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 573 9 3 4 5.3 O=C(O)Cc1cccc(NC(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCC3)CC2)c1 10.1021/jm950372w
40652201 205870 0 None - 1 Mouse 5.7 pIC50 = 5.7 Binding
Concentration required for binding affinity to neuropeptide (CCK-B) receptor in mouse cerebral cortexConcentration required for binding affinity to neuropeptide (CCK-B) receptor in mouse cerebral cortex
ChEMBL 407 9 3 3 4.2 CC(C)CCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1 10.1016/S0960-894X(97)00346-6
CHEMBL58852 205870 0 None - 1 Mouse 5.7 pIC50 = 5.7 Binding
Concentration required for binding affinity to neuropeptide (CCK-B) receptor in mouse cerebral cortexConcentration required for binding affinity to neuropeptide (CCK-B) receptor in mouse cerebral cortex
ChEMBL 407 9 3 3 4.2 CC(C)CCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1 10.1016/S0960-894X(97)00346-6
10530757 125341 0 None - 0 Mouse 6.7 pIC50 = 6.7 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 553 10 3 7 3.6 COC(=O)CC(CC(=O)OC)NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1021/jm970065l
CHEMBL341560 125341 0 None - 0 Mouse 6.7 pIC50 = 6.7 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 553 10 3 7 3.6 COC(=O)CC(CC(=O)OC)NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1021/jm970065l
44280178 109399 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 601 11 3 4 5.3 O=C(O)C[C@@H](Cc1ccccc1)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL30422 109399 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 601 11 3 4 5.3 O=C(O)C[C@@H](Cc1ccccc1)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
44280131 106368 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 680 11 4 5 5.8 O=C(O)C[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2ccccc12 10.1021/jm950372w
CHEMBL283914 106368 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 680 11 4 5 5.8 O=C(O)C[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2ccccc12 10.1021/jm950372w
44280214 114079 0 None - 1 Mouse 6.7 pIC50 = 6.7 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 770 16 6 10 3.6 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCCC(=O)NCCSCc4csc(N=C(N)N)n4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL31726 114079 0 None - 1 Mouse 6.7 pIC50 = 6.7 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 770 16 6 10 3.6 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCCC(=O)NCCSCc4csc(N=C(N)N)n4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
44280225 106739 0 None - 1 Mouse 5.7 pIC50 = 5.7 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 743 15 4 7 5.4 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL286475 106739 0 None - 1 Mouse 5.7 pIC50 = 5.7 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 743 15 4 7 5.4 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 10.1016/S0960-894X(96)00248-X
44349240 124895 0 None - 0 Rat 4.7 pIC50 = 4.7 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 368 11 3 3 3.0 CCCCCCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 10.1021/jm00079a003
CHEMBL340755 124895 0 None - 0 Rat 4.7 pIC50 = 4.7 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 368 11 3 3 3.0 CCCCCCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 10.1021/jm00079a003
44280123 106049 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 626 10 4 4 5.3 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm950372w
CHEMBL281903 106049 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 626 10 4 4 5.3 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm950372w
44303488 107836 0 None - 0 Mouse 5.7 pIC50 = 5.7 Binding
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 501 8 2 6 4.1 CC(Cn1nnc2ccccc21)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 10.1016/S0960-894X(97)00356-9
CHEMBL294735 107836 0 None - 0 Mouse 5.7 pIC50 = 5.7 Binding
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 501 8 2 6 4.1 CC(Cn1nnc2ccccc21)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 10.1016/S0960-894X(97)00356-9
10077166 106710 0 None 75 2 Rat 6.7 pIC50 = 6.7 Binding
Inhibitory activity against CCK-B receptorInhibitory activity against CCK-B receptor
ChEMBL 591 10 3 4 5.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N(CCc1ccc(Cl)cc1)CC(=O)O 10.1016/s0960-894x(98)00231-5
CHEMBL286247 106710 0 None 75 2 Rat 6.7 pIC50 = 6.7 Binding
Inhibitory activity against CCK-B receptorInhibitory activity against CCK-B receptor
ChEMBL 591 10 3 4 5.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N(CCc1ccc(Cl)cc1)CC(=O)O 10.1016/s0960-894x(98)00231-5
44280157 162508 0 None 75 2 Rat 6.7 pIC50 = 6.7 Binding
Inhibitory activity against CCK-B receptorInhibitory activity against CCK-B receptor
ChEMBL 667 8 3 5 6.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1CC[C@H](Oc2ccc(Cl)cc2Cl)C[C@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
CHEMBL405468 162508 0 None 75 2 Rat 6.7 pIC50 = 6.7 Binding
Inhibitory activity against CCK-B receptorInhibitory activity against CCK-B receptor
ChEMBL 667 8 3 5 6.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1CC[C@H](Oc2ccc(Cl)cc2Cl)C[C@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
CHEMBL205306 215947 0 None -109 3 Human 5.7 pIC50 = 5.7 Binding
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](CCCC)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm050921q
10668688 214311 0 None - 0 Mouse 6.7 pIC50 = 6.7 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 400 4 4 6 3.4 Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(N)c2)c1 10.1021/jm970373j
CHEMBL9465 214311 0 None - 0 Mouse 6.7 pIC50 = 6.7 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 400 4 4 6 3.4 Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(N)c2)c1 10.1021/jm970373j
44280102 109486 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 587 10 3 4 4.9 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(Cc1ccccc1)C(=O)O 10.1021/jm950372w
CHEMBL30481 109486 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 587 10 3 4 4.9 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(Cc1ccccc1)C(=O)O 10.1021/jm950372w
44387108 175033 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.
ChEMBL 650 9 3 5 4.7 COC(=O)[C@@]1(Cc2ccccc2)C[C@H]2[C@H](NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)C34CC5CC(CC(C5)C3)C4)CCCN2C1=O 10.1016/0960-894X(96)00160-6
CHEMBL433770 175033 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.
ChEMBL 650 9 3 5 4.7 COC(=O)[C@@]1(Cc2ccccc2)C[C@H]2[C@H](NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)C34CC5CC(CC(C5)C3)C4)CCCN2C1=O 10.1016/0960-894X(96)00160-6
10504136 213417 0 None - 0 Mouse 7.7 pIC50 = 7.7 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 459 7 3 7 4.3 COc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(OC(C)C)c2)c1 10.1021/jm970373j
CHEMBL8922 213417 0 None - 0 Mouse 7.7 pIC50 = 7.7 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 459 7 3 7 4.3 COc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(OC(C)C)c2)c1 10.1021/jm970373j
10791546 213862 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Compound was evaluated for functional activity on Cholecystokinin type B receptor (CCK-B) receptor carried out on guinea pig stomach cells.Compound was evaluated for functional activity on Cholecystokinin type B receptor (CCK-B) receptor carried out on guinea pig stomach cells.
ChEMBL 501 8 3 8 4.5 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(OC(C)C)c2)c1 10.1021/jm970373j
CHEMBL9188 213862 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Compound was evaluated for functional activity on Cholecystokinin type B receptor (CCK-B) receptor carried out on guinea pig stomach cells.Compound was evaluated for functional activity on Cholecystokinin type B receptor (CCK-B) receptor carried out on guinea pig stomach cells.
ChEMBL 501 8 3 8 4.5 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(OC(C)C)c2)c1 10.1021/jm970373j
CHEMBL438911 220585 0 None - 0 Bovine 7.7 pIC50 = 7.7 Binding
Concentration inhibiting [3H]propionyl-CCK-8 binding to cholecystokinin type B receptor of bovine striatum.Concentration inhibiting [3H]propionyl-CCK-8 binding to cholecystokinin type B receptor of bovine striatum.
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00100a033
10070677 168503 15 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 418 3 2 3 4.3 CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00121a004
CHEMBL41361 168503 15 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 418 3 2 3 4.3 CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00121a004
14888736 104862 0 None - 0 Bovine 7.7 pIC50 = 7.7 Binding
Inhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranesInhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranes
ChEMBL 974 29 10 11 1.2 CSCC[C@H](NC(=O)CCc1ccc(CC(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00107a037
CHEMBL273344 104862 0 None - 0 Bovine 7.7 pIC50 = 7.7 Binding
Inhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranesInhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranes
ChEMBL 974 29 10 11 1.2 CSCC[C@H](NC(=O)CCc1ccc(CC(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00107a037
44356868 32748 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 412 3 2 3 4.3 Cc1ccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc1C 10.1021/jm00078a018
CHEMBL135433 32748 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 412 3 2 3 4.3 Cc1ccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc1C 10.1021/jm00078a018
10346957 33726 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 531 7 2 4 4.9 CCN(CC)C(=O)C(C)N1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL136436 33726 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 531 7 2 4 4.9 CCN(CC)C(=O)C(C)N1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
44356801 172290 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 408 3 2 3 3.6 C#Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
CHEMBL424076 172290 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 408 3 2 3 3.6 C#Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
44386486 137468 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.
ChEMBL 650 9 3 5 4.7 COC(=O)[C@]1(Cc2ccccc2)C[C@@H]2[C@@H](NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)C34CC5CC(CC(C5)C3)C4)CCCN2C1=O 10.1016/0960-894X(96)00160-6
CHEMBL368356 137468 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.
ChEMBL 650 9 3 5 4.7 COC(=O)[C@]1(Cc2ccccc2)C[C@@H]2[C@@H](NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)C34CC5CC(CC(C5)C3)C4)CCCN2C1=O 10.1016/0960-894X(96)00160-6
10253366 123123 13 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 452 3 2 3 5.0 CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2Cl)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL335951 123123 13 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 452 3 2 3 5.0 CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2Cl)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
44281004 106855 0 None - 1 Human 6.7 pIC50 = 6.7 Binding
Inhibitory activity against gastrin receptor.Inhibitory activity against gastrin receptor.
ChEMBL 773 15 4 8 6.4 Cc1cccc(NC(=O)N[C@@H]2N=C(c3cccc(OC(=O)NCCCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00249-1
CHEMBL287295 106855 0 None - 1 Human 6.7 pIC50 = 6.7 Binding
Inhibitory activity against gastrin receptor.Inhibitory activity against gastrin receptor.
ChEMBL 773 15 4 8 6.4 Cc1cccc(NC(=O)N[C@@H]2N=C(c3cccc(OC(=O)NCCCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00249-1
19766168 66331 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 367 4 3 3 2.5 Cc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)O)C2=O)c1 10.1016/S0960-894X(00)80683-6
CHEMBL171722 66331 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 367 4 3 3 2.5 Cc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)O)C2=O)c1 10.1016/S0960-894X(00)80683-6
10474221 23621 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Concentration required to inhibit by 50% the specific binding of [3H]pentagastrin to Cholecystokinin type B receptor in rabbit gastric glandConcentration required to inhibit by 50% the specific binding of [3H]pentagastrin to Cholecystokinin type B receptor in rabbit gastric gland
ChEMBL 368 8 3 3 2.9 CC(C)(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 10.1021/jm00079a003
CHEMBL124822 23621 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Concentration required to inhibit by 50% the specific binding of [3H]pentagastrin to Cholecystokinin type B receptor in rabbit gastric glandConcentration required to inhibit by 50% the specific binding of [3H]pentagastrin to Cholecystokinin type B receptor in rabbit gastric gland
ChEMBL 368 8 3 3 2.9 CC(C)(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 10.1021/jm00079a003
44381489 103968 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
In vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic aciniIn vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic acini
ChEMBL 1124 30 10 12 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80679-4
CHEMBL268337 103968 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
In vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic aciniIn vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic acini
ChEMBL 1124 30 10 12 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80679-4
44382735 127541 0 None - 0 Mouse 5.7 pIC50 = 5.7 Binding
Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 646 13 4 4 6.1 O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1)NCCc1ccccc1 10.1016/S0960-894X(00)80687-3
CHEMBL355275 127541 0 None - 0 Mouse 5.7 pIC50 = 5.7 Binding
Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 646 13 4 4 6.1 O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1)NCCc1ccccc1 10.1016/S0960-894X(00)80687-3
14208267 211305 0 None - 0 Human 4.7 pIC50 = 4.7 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 380 3 2 4 3.1 N#Cc1ccc(C(=O)NC2N=C(c3ccccc3)c3ccccc3NC2=O)cc1 10.1021/jm00120a002
CHEMBL72710 211305 0 None - 0 Human 4.7 pIC50 = 4.7 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 380 3 2 4 3.1 N#Cc1ccc(C(=O)NC2N=C(c3ccccc3)c3ccccc3NC2=O)cc1 10.1021/jm00120a002
11062139 103452 0 None - 0 Mouse 6.7 pIC50 = 6.7 Binding
Evaluated for Cholecystokinin type B receptor antagonistic activity in which 20 pM [125I]BH-CCK-8S was used to label CCKB/gastrin binding sites in mouse cortical homogenatesEvaluated for Cholecystokinin type B receptor antagonistic activity in which 20 pM [125I]BH-CCK-8S was used to label CCKB/gastrin binding sites in mouse cortical homogenates
ChEMBL 703 8 5 6 5.5 O=C(O)c1cc(NC(=O)C2Cc3ccccc3CCCN2C(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1016/S0960-894X(97)00211-4
CHEMBL26390 103452 0 None - 0 Mouse 6.7 pIC50 = 6.7 Binding
Evaluated for Cholecystokinin type B receptor antagonistic activity in which 20 pM [125I]BH-CCK-8S was used to label CCKB/gastrin binding sites in mouse cortical homogenatesEvaluated for Cholecystokinin type B receptor antagonistic activity in which 20 pM [125I]BH-CCK-8S was used to label CCKB/gastrin binding sites in mouse cortical homogenates
ChEMBL 703 8 5 6 5.5 O=C(O)c1cc(NC(=O)C2Cc3ccccc3CCCN2C(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1016/S0960-894X(97)00211-4
11765552 120407 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cellsIn vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL 742 17 7 6 5.8 Cc1ccccc1NC(=O)NCCCC[C@@H](CNC(=O)CCC(=O)O)NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1021/jm00017a022
CHEMBL332263 120407 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cellsIn vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL 742 17 7 6 5.8 Cc1ccccc1NC(=O)NCCCC[C@@H](CNC(=O)CCC(=O)O)NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1021/jm00017a022
10740785 104086 0 None - 0 Mouse 6.7 pIC50 = 6.7 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 419 4 3 5 4.5 Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(Cl)c2)c1 10.1021/jm970373j
CHEMBL269142 104086 0 None - 0 Mouse 6.7 pIC50 = 6.7 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 419 4 3 5 4.5 Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(Cl)c2)c1 10.1021/jm970373j
44286379 107087 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
In vitro binding for half maximal inhibition of [125I]- cholecystokinin type B receptor in guinea pig cortexIn vitro binding for half maximal inhibition of [125I]- cholecystokinin type B receptor in guinea pig cortex
ChEMBL 852 21 6 9 3.3 CN(C(=O)[C@H](CCCCNC(=O)/C=C/c1cccnc1)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00037a006
CHEMBL289284 107087 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
In vitro binding for half maximal inhibition of [125I]- cholecystokinin type B receptor in guinea pig cortexIn vitro binding for half maximal inhibition of [125I]- cholecystokinin type B receptor in guinea pig cortex
ChEMBL 852 21 6 9 3.3 CN(C(=O)[C@H](CCCCNC(=O)/C=C/c1cccnc1)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00037a006
44303470 210044 0 None - 0 Mouse 5.6 pIC50 = 5.6 Binding
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 479 8 2 5 4.5 Cc1noc(C)c1CC(C)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 10.1016/S0960-894X(97)00356-9
CHEMBL64623 210044 0 None - 0 Mouse 5.6 pIC50 = 5.6 Binding
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 479 8 2 5 4.5 Cc1noc(C)c1CC(C)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 10.1016/S0960-894X(97)00356-9
15670985 213870 0 None - 0 Mouse 7.6 pIC50 = 7.6 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 490 9 3 5 3.2 COc1cccc(N(CC(=O)N(C)c2ccccc2)C(=O)CNC(=O)Nc2cccc(C(=O)O)c2)c1 10.1021/jm970373j
CHEMBL9195 213870 0 None - 0 Mouse 7.6 pIC50 = 7.6 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 490 9 3 5 3.2 COc1cccc(N(CC(=O)N(C)c2ccccc2)C(=O)CNC(=O)Nc2cccc(C(=O)O)c2)c1 10.1021/jm970373j
10070677 168503 15 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 418 3 2 3 4.3 CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00121a004
CHEMBL41361 168503 15 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 418 3 2 3 4.3 CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00121a004
73354293 113333 0 None - 0 Mouse 7.6 pIC50 = 7.6 Binding
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 650 12 6 5 4.6 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCP(=O)(O)O)c1ccccc1 10.1021/jm00092a007
CHEMBL314178 113333 0 None - 0 Mouse 7.6 pIC50 = 7.6 Binding
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 650 12 6 5 4.6 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCP(=O)(O)O)c1ccccc1 10.1021/jm00092a007
73351319 174943 0 None - 0 Mouse 7.6 pIC50 = 7.6 Binding
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 648 12 5 5 5.3 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCP(C)(=O)O)c1ccccc1 10.1021/jm00092a007
CHEMBL433148 174943 0 None - 0 Mouse 7.6 pIC50 = 7.6 Binding
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 648 12 5 5 5.3 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCP(C)(=O)O)c1ccccc1 10.1021/jm00092a007
44354100 123547 0 None - 0 Mouse 7.6 pIC50 = 7.6 Binding
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 628 13 5 5 4.7 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@@H](CNC(=O)CCC(=O)O)Cc1ccccc1 10.1021/jm00105a062
CHEMBL337661 123547 0 None - 0 Mouse 7.6 pIC50 = 7.6 Binding
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 628 13 5 5 4.7 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@@H](CNC(=O)CCC(=O)O)Cc1ccccc1 10.1021/jm00105a062
73346732 176700 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
Inhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic aciniInhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic acini
ChEMBL 1017 29 9 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCCc1ccccc1)CC(=O)O 10.1021/jm00072a024
CHEMBL444113 176700 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
Inhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic aciniInhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic acini
ChEMBL 1017 29 9 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCCc1ccccc1)CC(=O)O 10.1021/jm00072a024
44354100 127589 0 None - 0 Mouse 7.6 pIC50 = 7.6 Binding
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 628 13 5 5 4.7 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CNC(=O)CCC(=O)O)Cc1ccccc1 10.1016/S0960-894X(00)80685-X
CHEMBL355656 127589 0 None - 0 Mouse 7.6 pIC50 = 7.6 Binding
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 628 13 5 5 4.7 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CNC(=O)CCC(=O)O)Cc1ccccc1 10.1016/S0960-894X(00)80685-X
44368567 175514 0 None - 0 Mouse 7.6 pIC50 = 7.6 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 495 9 4 4 4.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1CCCCC1F)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
CHEMBL437039 175514 0 None - 0 Mouse 7.6 pIC50 = 7.6 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 495 9 4 4 4.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1CCCCC1F)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
44280740 107183 0 None - 1 Human 7.6 pIC50 = 7.6 Binding
Inhibitory activity against gastrin receptor.Inhibitory activity against gastrin receptor.
ChEMBL 787 17 4 8 6.3 CN1C(=O)[C@H](NC(=O)Nc2cccc(CCOC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
CHEMBL290122 107183 0 None - 1 Human 7.6 pIC50 = 7.6 Binding
Inhibitory activity against gastrin receptor.Inhibitory activity against gastrin receptor.
ChEMBL 787 17 4 8 6.3 CN1C(=O)[C@H](NC(=O)Nc2cccc(CCOC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
15673154 92770 0 None - 0 Mouse 7.6 pIC50 = 7.6 Binding
The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the mouse cerebral cortex (CCK-B);value ranges from 22 to 24The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the mouse cerebral cortex (CCK-B);value ranges from 22 to 24
ChEMBL 650 12 6 5 4.6 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCP(=O)(O)O)c1ccccc1 10.1016/S0960-894X(00)80652-6
CHEMBL2304155 92770 0 None - 0 Mouse 7.6 pIC50 = 7.6 Binding
The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the mouse cerebral cortex (CCK-B);value ranges from 22 to 24The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the mouse cerebral cortex (CCK-B);value ranges from 22 to 24
ChEMBL 650 12 6 5 4.6 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCP(=O)(O)O)c1ccccc1 10.1016/S0960-894X(00)80652-6
44376132 127024 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
The compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligandThe compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligand
ChEMBL 494 6 3 6 3.9 CC(C)CN1C(=O)[C@H](NC(=O)Nc2ccc(-c3nn[nH]n3)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00032a003
CHEMBL352264 127024 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
The compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligandThe compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligand
ChEMBL 494 6 3 6 3.9 CC(C)CN1C(=O)[C@H](NC(=O)Nc2ccc(-c3nn[nH]n3)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00032a003
10507109 116004 0 None 1 2 Human 7.6 pIC50 = 7.6 Binding
Binding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligandBinding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligand
ChEMBL 561 7 2 4 5.3 CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/jm960205b
CHEMBL321761 116004 0 None 1 2 Human 7.6 pIC50 = 7.6 Binding
Binding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligandBinding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligand
ChEMBL 561 7 2 4 5.3 CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/jm960205b
14843044 106425 0 None - 0 Mouse 6.6 pIC50 = 6.6 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 511 4 1 3 6.4 O=c1c2ccccc2nc(CCc2c[nH]c3ccc(Br)cc23)n1-c1cccc(C(F)(F)F)c1 10.1021/jm00108a040
CHEMBL284317 106425 0 None - 0 Mouse 6.6 pIC50 = 6.6 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 511 4 1 3 6.4 O=c1c2ccccc2nc(CCc2c[nH]c3ccc(Br)cc23)n1-c1cccc(C(F)(F)F)c1 10.1021/jm00108a040
44280116 106408 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 672 12 3 6 5.8 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
CHEMBL284183 106408 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 672 12 3 6 5.8 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
44334354 11393 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 517 9 2 4 5.0 Cc1cccc(NC(=O)N[C@H](COCc2ccccc2)C(=O)N2CCC(C(=O)c3ccc(F)cc3)CC2)c1 10.1016/0960-894X(95)00537-3
CHEMBL102879 11393 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 517 9 2 4 5.0 Cc1cccc(NC(=O)N[C@H](COCc2ccccc2)C(=O)N2CCC(C(=O)c3ccc(F)cc3)CC2)c1 10.1016/0960-894X(95)00537-3
10252890 32395 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 444 5 2 5 3.7 COc1cc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc(OC)c1 10.1021/jm00078a018
CHEMBL135167 32395 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 444 5 2 5 3.7 COc1cc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc(OC)c1 10.1021/jm00078a018
44349023 23126 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 384 8 3 3 3.4 CC(C)(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1ccc2ccccc2c1 10.1021/jm00079a003
CHEMBL122922 23126 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 384 8 3 3 3.4 CC(C)(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1ccc2ccccc2c1 10.1021/jm00079a003
44349027 23598 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 438 7 3 5 2.9 O=C(O)CCC(NC(=O)c1cnc2ccccc2c1)C(=O)NN1CCC2(CCCC2)CC1 10.1021/jm00079a003
CHEMBL124732 23598 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 438 7 3 5 2.9 O=C(O)CCC(NC(=O)c1cnc2ccccc2c1)C(=O)NN1CCC2(CCCC2)CC1 10.1021/jm00079a003
44349429 23609 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 406 7 3 4 3.0 O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)C1CC2CCCCC2CN1 10.1021/jm00079a003
CHEMBL124780 23609 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 406 7 3 4 3.0 O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)C1CC2CCCCC2CN1 10.1021/jm00079a003
71456173 85259 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 455 7 3 4 3.6 O=C(O)CC[C@H](NC(=O)c1ccc(Cl)c(Cl)c1)C(=O)NN1CCC2(CCCC2)CC1 10.1021/jm00079a003
CHEMBL2111826 85259 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 455 7 3 4 3.6 O=C(O)CC[C@H](NC(=O)c1ccc(Cl)c(Cl)c1)C(=O)NN1CCC2(CCCC2)CC1 10.1021/jm00079a003
10531 8202 21 None - 24 Mouse 4.6 pIC50 = 4.6 Binding
Concentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranesConcentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranes
ChEMBL 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 10.1016/S0960-894X(00)80644-7
121 8202 21 None - 24 Mouse 4.6 pIC50 = 4.6 Binding
Concentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranesConcentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranes
ChEMBL 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 10.1016/S0960-894X(00)80644-7
888 8202 21 None - 24 Mouse 4.6 pIC50 = 4.6 Binding
Concentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranesConcentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranes
ChEMBL 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 10.1016/S0960-894X(00)80644-7
CHEMBL1732 8202 21 None - 24 Mouse 4.6 pIC50 = 4.6 Binding
Concentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranesConcentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranes
ChEMBL 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 10.1016/S0960-894X(00)80644-7
DB00320 8202 21 None - 24 Mouse 4.6 pIC50 = 4.6 Binding
Concentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranesConcentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranes
ChEMBL 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 10.1016/S0960-894X(00)80644-7
44348808 24707 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Concentration required to inhibit by 50% the specific binding of [3H]pentagastrin to CCK-B in rabbit gastric glandConcentration required to inhibit by 50% the specific binding of [3H]pentagastrin to CCK-B in rabbit gastric gland
ChEMBL 451 7 3 4 3.9 O=C(O)CCC(NC(=O)c1ccc2ccccc2c1)C(=O)NN1CCC2(CCCCC2)CC1 10.1021/jm00079a003
CHEMBL125925 24707 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Concentration required to inhibit by 50% the specific binding of [3H]pentagastrin to CCK-B in rabbit gastric glandConcentration required to inhibit by 50% the specific binding of [3H]pentagastrin to CCK-B in rabbit gastric gland
ChEMBL 451 7 3 4 3.9 O=C(O)CCC(NC(=O)c1ccc2ccccc2c1)C(=O)NN1CCC2(CCCCC2)CC1 10.1021/jm00079a003
44360340 39478 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 457 5 1 4 5.1 CN1c2ccccc2C(c2ccccc2F)=NCC1CNC(=O)Cc1cccc2sccc12 10.1021/jm00163a069
CHEMBL141354 39478 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 457 5 1 4 5.1 CN1c2ccccc2C(c2ccccc2F)=NCC1CNC(=O)Cc1cccc2sccc12 10.1021/jm00163a069
CHEMBL411079 219641 0 None - 0 Bovine 5.6 pIC50 = 5.6 Binding
Concentration inhibiting [3H]propionyl-CCK-8 binding to cholecystokinin type B receptor of bovine striatum.Concentration inhibiting [3H]propionyl-CCK-8 binding to cholecystokinin type B receptor of bovine striatum.
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N1CSC(C)(C)[C@@H]1C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00100a033
44396732 73667 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Inhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenatesInhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenates
ChEMBL 545 7 2 6 4.5 CN(C)c1ccc(N2C(=O)CC3[C@H](N[C@@H](Cc4c[nH]c5ccccc45)C(=O)OC(C)(C)C)CCCN3C2=O)cc1 10.1021/jm0498755
CHEMBL186438 73667 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Inhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenatesInhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenates
ChEMBL 545 7 2 6 4.5 CN(C)c1ccc(N2C(=O)CC3[C@H](N[C@@H](Cc4c[nH]c5ccccc45)C(=O)OC(C)(C)C)CCCN3C2=O)cc1 10.1021/jm0498755
10962743 85372 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Inhibition of [3H]pCCK-8 specific binding cholecystokinin type B receptor in rat cerebral cortex membranesInhibition of [3H]pCCK-8 specific binding cholecystokinin type B receptor in rat cerebral cortex membranes
ChEMBL 559 6 3 5 4.4 Cc1ccc(N2C(=O)C[C@@H]3[C@@H](NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)OC(C)(C)C)CCCN3C2=O)cc1 10.1021/jm010813d
CHEMBL2112239 85372 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Inhibition of [3H]pCCK-8 specific binding cholecystokinin type B receptor in rat cerebral cortex membranesInhibition of [3H]pCCK-8 specific binding cholecystokinin type B receptor in rat cerebral cortex membranes
ChEMBL 559 6 3 5 4.4 Cc1ccc(N2C(=O)C[C@@H]3[C@@H](NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)OC(C)(C)C)CCCN3C2=O)cc1 10.1021/jm010813d
11028319 86432 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Inhibition of [3H]pCCK-8 specific binding cholecystokinin type B receptor in rat cerebral cortex membranesInhibition of [3H]pCCK-8 specific binding cholecystokinin type B receptor in rat cerebral cortex membranes
ChEMBL 588 7 3 6 4.2 CN(C)c1ccc(N2C(=O)C[C@@H]3[C@@H](NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)OC(C)(C)C)CCCN3C2=O)cc1 10.1021/jm010813d
CHEMBL2115130 86432 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Inhibition of [3H]pCCK-8 specific binding cholecystokinin type B receptor in rat cerebral cortex membranesInhibition of [3H]pCCK-8 specific binding cholecystokinin type B receptor in rat cerebral cortex membranes
ChEMBL 588 7 3 6 4.2 CN(C)c1ccc(N2C(=O)C[C@@H]3[C@@H](NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)OC(C)(C)C)CCCN3C2=O)cc1 10.1021/jm010813d
10078362 106567 0 None - 0 Mouse 6.6 pIC50 = 6.6 Binding
Evaluated for Cholecystokinin type B receptor antagonistic activity in which 20 pM [125I]BH-CCK-8S was used to label CCKB/gastrin binding sites in mouse cortical homogenatesEvaluated for Cholecystokinin type B receptor antagonistic activity in which 20 pM [125I]BH-CCK-8S was used to label CCKB/gastrin binding sites in mouse cortical homogenates
ChEMBL 689 8 5 6 5.2 O=C(O)c1cc(NC(=O)C2Cc3ccccc3CCN2C(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1016/S0960-894X(97)00211-4
CHEMBL285305 106567 0 None - 0 Mouse 6.6 pIC50 = 6.6 Binding
Evaluated for Cholecystokinin type B receptor antagonistic activity in which 20 pM [125I]BH-CCK-8S was used to label CCKB/gastrin binding sites in mouse cortical homogenatesEvaluated for Cholecystokinin type B receptor antagonistic activity in which 20 pM [125I]BH-CCK-8S was used to label CCKB/gastrin binding sites in mouse cortical homogenates
ChEMBL 689 8 5 6 5.2 O=C(O)c1cc(NC(=O)C2Cc3ccccc3CCN2C(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1016/S0960-894X(97)00211-4
90663996 113602 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 919 23 9 11 2.4 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1cccc(OS(=O)(=O)O)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL3144565 113602 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 919 23 9 11 2.4 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1cccc(OS(=O)(=O)O)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
10555571 111354 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8
ChEMBL 601 8 0 6 5.9 COc1ccc(N(C(=O)CN2C(=O)C(Cc3nn(C)c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm960249k
CHEMBL310466 111354 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8
ChEMBL 601 8 0 6 5.9 COc1ccc(N(C(=O)CN2C(=O)C(Cc3nn(C)c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm960249k
10555571 111354 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 601 8 0 6 5.9 COc1ccc(N(C(=O)CN2C(=O)C(Cc3nn(C)c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm970265x
CHEMBL310466 111354 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 601 8 0 6 5.9 COc1ccc(N(C(=O)CN2C(=O)C(Cc3nn(C)c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm970265x
15667015 168633 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 990 29 10 11 2.0 CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
CHEMBL414793 168633 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 990 29 10 11 2.0 CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
9985099 124056 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 552 5 3 3 6.0 CC(C)(C)NC(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](c2ccccc2)c2cc(Cl)ccc21 10.1021/jm00048a015
CHEMBL339515 124056 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 552 5 3 3 6.0 CC(C)(C)NC(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](c2ccccc2)c2cc(Cl)ccc21 10.1021/jm00048a015
14208226 84603 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 426 3 2 3 3.9 CN1C(=O)[C@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL2092871 84603 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 426 3 2 3 3.9 CN1C(=O)[C@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
44280029 103216 0 None - 1 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 740 15 6 9 3.5 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCC(=O)NCCSCc3csc(N=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
CHEMBL262125 103216 0 None - 1 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 740 15 6 9 3.5 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCC(=O)NCCSCc3csc(N=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
44381550 172012 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptorDisplacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptor
ChEMBL 842 23 11 10 3.0 Cc1ccccc1NC(=O)NCCCC[C@@H](CNN[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)NNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1016/S0960-894X(00)80680-0
CHEMBL422919 172012 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptorDisplacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptor
ChEMBL 842 23 11 10 3.0 Cc1ccccc1NC(=O)NCCCC[C@@H](CNN[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)NNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1016/S0960-894X(00)80680-0
13822921 108405 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [125I]gastrin from guinea pig gastric glandsDisplacement of [125I]gastrin from guinea pig gastric glands
ChEMBL 431 3 1 5 4.3 O=C(NC1N=C(c2ccccc2F)c2ccccc2-n2cnnc21)c1ccc(Cl)cc1 10.1021/jm00396a028
CHEMBL298948 108405 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [125I]gastrin from guinea pig gastric glandsDisplacement of [125I]gastrin from guinea pig gastric glands
ChEMBL 431 3 1 5 4.3 O=C(NC1N=C(c2ccccc2F)c2ccccc2-n2cnnc21)c1ccc(Cl)cc1 10.1021/jm00396a028
14208275 74521 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 443 3 1 3 4.7 CN1C(=O)[C@@H](NC(=O)c2ccc(C(C)(C)C)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL1907849 74521 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 443 3 1 3 4.7 CN1C(=O)[C@@H](NC(=O)c2ccc(C(C)(C)C)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
14208270 74526 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 447 3 1 3 4.0 CN1C(=O)[C@H](NC(=O)c2ccc(Br)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
CHEMBL1907853 74526 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 447 3 1 3 4.0 CN1C(=O)[C@H](NC(=O)c2ccc(Br)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
15167812 108973 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 437 3 1 3 3.6 CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)[N+]([O-])=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL302825 108973 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 437 3 1 3 3.6 CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)[N+]([O-])=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
10078285 128285 0 None - 0 Mouse 5.6 pIC50 = 5.6 Binding
Inhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptorInhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptor
ChEMBL 680 12 3 6 5.7 C[Si](C)(C)CCOC(=O)C[C@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@H]2C[C@H](NC(=O)OCc3ccccc3)C(=O)N12 10.1016/s0960-894x(98)00677-5
CHEMBL358334 128285 0 None - 0 Mouse 5.6 pIC50 = 5.6 Binding
Inhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptorInhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptor
ChEMBL 680 12 3 6 5.7 C[Si](C)(C)CCOC(=O)C[C@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@H]2C[C@H](NC(=O)OCc3ccccc3)C(=O)N12 10.1016/s0960-894x(98)00677-5
44375064 59711 0 None - 0 Mouse 4.6 pIC50 = 4.6 Binding
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 554 10 6 7 4.0 O=C(O)c1ccc(N/C(S)=N\Nc2ccc(S(=O)(=O)NCCc3c[nH]c4ccccc34)cc2[N+](=O)[O-])cc1 10.1016/s0960-894x(01)00044-0
CHEMBL159623 59711 0 None - 0 Mouse 4.6 pIC50 = 4.6 Binding
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 554 10 6 7 4.0 O=C(O)c1ccc(N/C(S)=N\Nc2ccc(S(=O)(=O)NCCc3c[nH]c4ccccc34)cc2[N+](=O)[O-])cc1 10.1016/s0960-894x(01)00044-0
44375437 126845 0 None - 0 Mouse 4.6 pIC50 = 4.6 Binding
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 506 11 6 7 2.3 O=C(O)CCNS(=O)(=O)c1ccc(N/N=C(/S)NCCc2c[nH]c3ccccc23)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
CHEMBL350631 126845 0 None - 0 Mouse 4.6 pIC50 = 4.6 Binding
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 506 11 6 7 2.3 O=C(O)CCNS(=O)(=O)c1ccc(N/N=C(/S)NCCc2c[nH]c3ccccc23)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
44375447 172129 0 None - 0 Mouse 5.6 pIC50 = 5.6 Binding
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 610 14 5 7 4.6 O=C(O)CCCN(Cc1ccccc1)S(=O)(=O)c1ccc(N/N=C(/S)NCCc2c[nH]c3ccccc23)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
CHEMBL423630 172129 0 None - 0 Mouse 5.6 pIC50 = 5.6 Binding
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 610 14 5 7 4.6 O=C(O)CCCN(Cc1ccccc1)S(=O)(=O)c1ccc(N/N=C(/S)NCCc2c[nH]c3ccccc23)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
443375 214385 45 None -316 5 Human 6.6 pIC50 = 6.6 Binding
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80683-6
CHEMBL9506 214385 45 None -316 5 Human 6.6 pIC50 = 6.6 Binding
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80683-6
443375 214385 45 None -316 5 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00121a004
CHEMBL9506 214385 45 None -316 5 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00121a004
443375 214385 45 None -316 5 Human 6.6 pIC50 = 6.6 Binding
Inhibition of Cholecystokinin type B receptor induced guinea pig gall bladder contractions when given intravenouslyInhibition of Cholecystokinin type B receptor induced guinea pig gall bladder contractions when given intravenously
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm020424z
CHEMBL9506 214385 45 None -316 5 Human 6.6 pIC50 = 6.6 Binding
Inhibition of Cholecystokinin type B receptor induced guinea pig gall bladder contractions when given intravenouslyInhibition of Cholecystokinin type B receptor induced guinea pig gall bladder contractions when given intravenously
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm020424z
443375 214385 45 None -316 5 Human 6.6 pIC50 = 6.6 Binding
Inhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesInhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranes
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00609-9
CHEMBL9506 214385 45 None -316 5 Human 6.6 pIC50 = 6.6 Binding
Inhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesInhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranes
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00609-9
443375 214385 45 None -316 5 Human 6.6 pIC50 = 6.6 Binding
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00163a069
CHEMBL9506 214385 45 None -316 5 Human 6.6 pIC50 = 6.6 Binding
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00163a069
155535579 178829 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1836 71 17 23 2.9 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4471871 178829 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1836 71 17 23 2.9 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
10790099 214053 0 None - 0 Mouse 7.6 pIC50 = 7.6 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 459 7 3 7 4.3 COc1ccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(OC(C)C)c2)cc1 10.1021/jm970373j
CHEMBL9311 214053 0 None - 0 Mouse 7.6 pIC50 = 7.6 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 459 7 3 7 4.3 COc1ccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(OC(C)C)c2)cc1 10.1021/jm970373j
CHEMBL3143668 217958 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/0960-894X(96)00160-6
CHEMBL64605 222635 7 None -4 3 Human 7.6 pIC50 = 7.6 Binding
Compound was tested for its inhibitory activity in cortical cholecystokinin type B receptor in guinea pigCompound was tested for its inhibitory activity in cortical cholecystokinin type B receptor in guinea pig
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00105a068
CHEMBL64605 222635 7 None -4 3 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00173a006
CHEMBL64605 222635 7 None -4 3 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptorDisplacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptor
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80680-0
CHEMBL64605 222635 7 None 4 3 Rat 7.6 pIC50 = 7.6 Binding
Displacement of [3H]propionylCCK8 from rat cerebral cortex CCK2Displacement of [3H]propionylCCK8 from rat cerebral cortex CCK2
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm050689o
CHEMBL64605 222635 7 None -4 3 Human 7.6 pIC50 = 7.6 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
90663193 113388 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibitory activity against Cholecystokinin type B receptor using [125I]- BH-CCK-8 as radioligand in cortex tissue of guinea pigInhibitory activity against Cholecystokinin type B receptor using [125I]- BH-CCK-8 as radioligand in cortex tissue of guinea pig
ChEMBL 739 17 8 9 1.7 CSCC[C@H](NC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)C(=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm960509y
CHEMBL3142902 113388 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibitory activity against Cholecystokinin type B receptor using [125I]- BH-CCK-8 as radioligand in cortex tissue of guinea pigInhibitory activity against Cholecystokinin type B receptor using [125I]- BH-CCK-8 as radioligand in cortex tissue of guinea pig
ChEMBL 739 17 8 9 1.7 CSCC[C@H](NC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)C(=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm960509y
44329055 214743 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 554 7 3 3 6.1 CCc1ccccc1[C@H]1C[C@@H](NC(=O)Nc2cccc(C)c2)C(=O)N(CC(=O)NC(C)(C)C)[C@@H](c2ccccc2)C1 10.1016/S0960-894X(01)80832-5
CHEMBL97133 214743 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 554 7 3 3 6.1 CCc1ccccc1[C@H]1C[C@@H](NC(=O)Nc2cccc(C)c2)C(=O)N(CC(=O)NC(C)(C)C)[C@@H](c2ccccc2)C1 10.1016/S0960-894X(01)80832-5
44280215 106606 0 None - 1 Human 7.6 pIC50 = 7.6 Binding
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 756 15 6 10 3.3 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCC(=O)NCCSCc4csc(N=C(N)N)n4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL285586 106606 0 None - 1 Human 7.6 pIC50 = 7.6 Binding
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 756 15 6 10 3.3 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCC(=O)NCCSCc4csc(N=C(N)N)n4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL64605 222635 7 None -4 3 Human 7.6 pIC50 = 7.6 Binding
Tested for the inhibition of specific [3H]propionyl-CCK-8 binding to guinea pig pancreatic Cholecystokinin type B receptorTested for the inhibition of specific [3H]propionyl-CCK-8 binding to guinea pig pancreatic Cholecystokinin type B receptor
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(97)00107-8
10507109 116004 0 None 1 2 Human 7.6 pIC50 = 7.6 Binding
Compound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transfected with cDNA of human Cholecystokinin type B receptorCompound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transfected with cDNA of human Cholecystokinin type B receptor
ChEMBL 561 7 2 4 5.3 CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/jm9601664
CHEMBL321761 116004 0 None 1 2 Human 7.6 pIC50 = 7.6 Binding
Compound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transfected with cDNA of human Cholecystokinin type B receptorCompound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transfected with cDNA of human Cholecystokinin type B receptor
ChEMBL 561 7 2 4 5.3 CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/jm9601664
10507109 116004 0 None 1 2 Human 7.6 pIC50 = 7.6 Binding
Concentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cellsConcentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL 561 7 2 4 5.3 CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/jm950626d
CHEMBL321761 116004 0 None 1 2 Human 7.6 pIC50 = 7.6 Binding
Concentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cellsConcentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL 561 7 2 4 5.3 CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/jm950626d
10626596 119558 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 555 7 1 4 5.6 O=C1C(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc2N1CC(=O)N(c1ccccc1)C1CC1 10.1021/jm970265x
CHEMBL330566 119558 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 555 7 1 4 5.6 O=C1C(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc2N1CC(=O)N(c1ccccc1)C1CC1 10.1021/jm970265x
10507109 116004 0 None 1 2 Human 7.6 pIC50 = 7.6 Binding
Tested for 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecystokinin type B receptorTested for 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecystokinin type B receptor
ChEMBL 561 7 2 4 5.3 CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1016/S0960-894X(97)00062-0
CHEMBL321761 116004 0 None 1 2 Human 7.6 pIC50 = 7.6 Binding
Tested for 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecystokinin type B receptorTested for 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecystokinin type B receptor
ChEMBL 561 7 2 4 5.3 CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1016/S0960-894X(97)00062-0
155519400 177213 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter methodDisplacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter method
ChEMBL 1409 38 15 21 -2.1 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)n1cc([C@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)nn1 10.1021/acs.jmedchem.9b01936
CHEMBL4448553 177213 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter methodDisplacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter method
ChEMBL 1409 38 15 21 -2.1 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)n1cc([C@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)nn1 10.1021/acs.jmedchem.9b01936
10649296 37549 0 None - 0 Mouse 7.6 pIC50 = 7.6 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 507 6 4 4 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H]1CCCCC[C@@H]1O 10.1021/jm970065l
CHEMBL139601 37549 0 None - 0 Mouse 7.6 pIC50 = 7.6 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 507 6 4 4 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H]1CCCCC[C@@H]1O 10.1021/jm970065l
CHEMBL382051 219072 0 None -131 4 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm050921q
10325426 114378 0 None - 0 Mouse 7.6 pIC50 = 7.6 Binding
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 557 10 3 4 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccc1)CC(=O)O 10.1016/S0960-894X(01)80769-1
CHEMBL318963 114378 0 None - 0 Mouse 7.6 pIC50 = 7.6 Binding
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 557 10 3 4 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccc1)CC(=O)O 10.1016/S0960-894X(01)80769-1
155516160 176837 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter methodDisplacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter method
ChEMBL 1399 39 16 19 -2.7 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)C[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.9b01936
CHEMBL4443016 176837 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter methodDisplacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter method
ChEMBL 1399 39 16 19 -2.7 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)C[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.9b01936
73351327 89200 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat TcellsInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat Tcells
ChEMBL 1019 29 9 11 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCOc1ccccc1)CC(=O)O 10.1021/jm00072a024
CHEMBL217424 89200 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat TcellsInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat Tcells
ChEMBL 1019 29 9 11 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCOc1ccccc1)CC(=O)O 10.1021/jm00072a024
10073533 29326 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 472 7 3 5 3.5 COc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CCC(=O)O)C2=O)c1 10.1021/jm00078a018
CHEMBL132603 29326 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 472 7 3 5 3.5 COc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CCC(=O)O)C2=O)c1 10.1021/jm00078a018
44376191 172104 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
The compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligandThe compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligand
ChEMBL 452 4 3 6 2.8 CN1C(=O)[C@H](NC(=O)Nc2ccc(-c3nn[nH]n3)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00032a003
CHEMBL423472 172104 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
The compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligandThe compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligand
ChEMBL 452 4 3 6 2.8 CN1C(=O)[C@H](NC(=O)Nc2ccc(-c3nn[nH]n3)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00032a003
19766168 66331 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 367 4 3 3 2.5 Cc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)O)C2=O)c1 10.1016/S0960-894X(00)80683-6
CHEMBL171722 66331 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 367 4 3 3 2.5 Cc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)O)C2=O)c1 10.1016/S0960-894X(00)80683-6
CHEMBL290444 217656 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cellsBinding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cells
ChEMBL None None None CCS[C@H]1CCN(C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(C)=O)[C@@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00001a019
44382487 172415 0 None - 0 Mouse 5.6 pIC50 = 5.6 Binding
Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)
ChEMBL 518 10 4 4 2.7 CC(C)C[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N1C[C@H](Cc2ccccc2)NC(=O)[C@@H]1CC(=O)O 10.1016/S0960-894X(01)80253-5
CHEMBL424370 172415 0 None - 0 Mouse 5.6 pIC50 = 5.6 Binding
Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)
ChEMBL 518 10 4 4 2.7 CC(C)C[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N1C[C@H](Cc2ccccc2)NC(=O)[C@@H]1CC(=O)O 10.1016/S0960-894X(01)80253-5
9988264 116500 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL 888 22 9 8 3.5 Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
CHEMBL322955 116500 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL 888 22 9 8 3.5 Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
14208241 74525 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 421 3 1 3 4.0 CN1C(=O)[C@@H](NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00121a004
CHEMBL1907852 74525 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 421 3 1 3 4.0 CN1C(=O)[C@@H](NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00121a004
44381562 175393 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptorDisplacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptor
ChEMBL 827 22 10 9 3.5 Cc1ccccc1NC(=O)NCCCC[C@H](NNC[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80680-0
CHEMBL436053 175393 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptorDisplacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptor
ChEMBL 827 22 10 9 3.5 Cc1ccccc1NC(=O)NCCCC[C@H](NNC[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80680-0
CHEMBL328422 218075 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL None None None Cc1cccc(C)c1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
3960 9124 23 None - 1 Human 4.6 pIC50 = 4.6 Binding
Concentration required to inhibit by 50% the specific binding of [3H]pentagastrin to cholecystokinin type B receptor in rabbit gastric glandConcentration required to inhibit by 50% the specific binding of [3H]pentagastrin to cholecystokinin type B receptor in rabbit gastric gland
ChEMBL 458 14 2 3 5.2 CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCCC 10.1021/jm00079a003
891 9124 23 None - 1 Human 4.6 pIC50 = 4.6 Binding
Concentration required to inhibit by 50% the specific binding of [3H]pentagastrin to cholecystokinin type B receptor in rabbit gastric glandConcentration required to inhibit by 50% the specific binding of [3H]pentagastrin to cholecystokinin type B receptor in rabbit gastric gland
ChEMBL 458 14 2 3 5.2 CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCCC 10.1021/jm00079a003
CHEMBL24938 9124 23 None - 1 Human 4.6 pIC50 = 4.6 Binding
Concentration required to inhibit by 50% the specific binding of [3H]pentagastrin to cholecystokinin type B receptor in rabbit gastric glandConcentration required to inhibit by 50% the specific binding of [3H]pentagastrin to cholecystokinin type B receptor in rabbit gastric gland
ChEMBL 458 14 2 3 5.2 CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCCC 10.1021/jm00079a003
13953692 108498 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Displacement of [125I]gastrin from guinea pig gastric glandsDisplacement of [125I]gastrin from guinea pig gastric glands
ChEMBL 407 3 1 4 5.0 Fc1ccccc1C1=N[C@H](Cc2c[nH]c3ccccc23)c2nncn2-c2ccccc21 10.1021/jm00396a028
CHEMBL299538 108498 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Displacement of [125I]gastrin from guinea pig gastric glandsDisplacement of [125I]gastrin from guinea pig gastric glands
ChEMBL 407 3 1 4 5.0 Fc1ccccc1C1=N[C@H](Cc2c[nH]c3ccccc23)c2nncn2-c2ccccc21 10.1021/jm00396a028
14208220 211309 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 365 6 1 5 1.5 CCOC(=O)CN1C(=O)C(NC=O)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
CHEMBL72738 211309 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 365 6 1 5 1.5 CCOC(=O)CN1C(=O)C(NC=O)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
14208213 211387 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 362 3 3 3 2.7 O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccc[nH]1 10.1021/jm00120a002
CHEMBL73272 211387 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 362 3 3 3 2.7 O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccc[nH]1 10.1021/jm00120a002
5279119 211532 1 None - 0 Human 4.6 pIC50 = 4.6 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 423 3 2 3 4.5 O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccc(Cl)c(Cl)c1 10.1021/jm00120a002
CHEMBL74515 211532 1 None - 0 Human 4.6 pIC50 = 4.6 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 423 3 2 3 4.5 O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccc(Cl)c(Cl)c1 10.1021/jm00120a002
44366107 178498 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
In vitro inhibition of binding of [125I](Nle)-HG-13 labeled gCholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I](Nle)-HG-13 labeled gCholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 649 16 6 6 3.8 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(=O)O)CC(=O)NCCc1ccccc1 10.1021/jm00123a003
CHEMBL446693 178498 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
In vitro inhibition of binding of [125I](Nle)-HG-13 labeled gCholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I](Nle)-HG-13 labeled gCholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 649 16 6 6 3.8 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(=O)O)CC(=O)NCCc1ccccc1 10.1021/jm00123a003
14154723 96295 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.
ChEMBL 636 14 7 6 3.6 CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(=O)O)NC(=O)NCc1ccccc1 10.1021/jm00388a002
CHEMBL2373213 96295 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.
ChEMBL 636 14 7 6 3.6 CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(=O)O)NC(=O)NCc1ccccc1 10.1021/jm00388a002
10348659 8585 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Concentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cellsConcentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL 604 8 2 5 5.4 O=C(NC1C(=O)N(c2ccccc2)c2c(N(C1=O)CC(=O)N(c1ccc(cc1)N(C)C)C(C)C)cccc2)Nc1ccccc1 10.1021/jm950626d
866 8585 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Concentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cellsConcentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL 604 8 2 5 5.4 O=C(NC1C(=O)N(c2ccccc2)c2c(N(C1=O)CC(=O)N(c1ccc(cc1)N(C)C)C(C)C)cccc2)Nc1ccccc1 10.1021/jm950626d
CHEMBL1184355 8585 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Concentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cellsConcentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL 604 8 2 5 5.4 O=C(NC1C(=O)N(c2ccccc2)c2c(N(C1=O)CC(=O)N(c1ccc(cc1)N(C)C)C(C)C)cccc2)Nc1ccccc1 10.1021/jm950626d
10841358 214199 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 605 8 1 5 6.0 COc1ccc(N(C(=O)CN2C(=O)C(Cc3n[nH]c4ccc(F)cc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm970265x
CHEMBL94005 214199 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 605 8 1 5 6.0 COc1ccc(N(C(=O)CN2C(=O)C(Cc3n[nH]c4ccc(F)cc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm970265x
44280233 105984 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 672 13 3 5 5.1 CN(Cc1ccccc1)C(=O)[C@@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL281490 105984 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 672 13 3 5 5.1 CN(Cc1ccccc1)C(=O)[C@@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
44280028 105953 0 None - 1 Mouse 6.6 pIC50 = 6.6 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 768 17 6 9 4.3 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCCCC(=O)NCCSCc3csc(N=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
CHEMBL281318 105953 0 None - 1 Mouse 6.6 pIC50 = 6.6 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 768 17 6 9 4.3 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCCCC(=O)NCCSCc3csc(N=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
44344743 170352 0 None - 0 Mouse 6.6 pIC50 = 6.6 Binding
Half maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortexHalf maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 555 11 4 3 5.3 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)CC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccccc1 10.1021/jm000937a
CHEMBL420320 170352 0 None - 0 Mouse 6.6 pIC50 = 6.6 Binding
Half maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortexHalf maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 555 11 4 3 5.3 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)CC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccccc1 10.1021/jm000937a
904 9800 10 None - 1 Mouse 6.6 pIC50 = 6.6 Binding
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1016/S0960-894X(00)80685-X
9915756 9800 10 None - 1 Mouse 6.6 pIC50 = 6.6 Binding
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1016/S0960-894X(00)80685-X
CHEMBL2111204 9800 10 None - 1 Mouse 6.6 pIC50 = 6.6 Binding
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1016/S0960-894X(00)80685-X
CHEMBL356898 9800 10 None - 1 Mouse 6.6 pIC50 = 6.6 Binding
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1016/S0960-894X(00)80685-X
904 9800 10 None - 1 Mouse 6.6 pIC50 = 6.6 Binding
Inhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptorInhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptor
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1016/s0960-894x(98)00677-5
9915756 9800 10 None - 1 Mouse 6.6 pIC50 = 6.6 Binding
Inhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptorInhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptor
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1016/s0960-894x(98)00677-5
CHEMBL2111204 9800 10 None - 1 Mouse 6.6 pIC50 = 6.6 Binding
Inhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptorInhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptor
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1016/s0960-894x(98)00677-5
CHEMBL356898 9800 10 None - 1 Mouse 6.6 pIC50 = 6.6 Binding
Inhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptorInhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptor
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1016/s0960-894x(98)00677-5
44210425 172073 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 439 5 2 5 3.5 COc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)OC(C)(C)C)C2=O)c1 10.1016/S0960-894X(00)80683-6
CHEMBL423278 172073 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 439 5 2 5 3.5 COc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)OC(C)(C)C)C2=O)c1 10.1016/S0960-894X(00)80683-6
10623881 214376 0 None - 0 Mouse 7.6 pIC50 = 7.6 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 461 6 3 7 3.9 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(F)c2)c1 10.1021/jm970373j
CHEMBL9501 214376 0 None - 0 Mouse 7.6 pIC50 = 7.6 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 461 6 3 7 3.9 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(F)c2)c1 10.1021/jm970373j
195737 130442 5 None - 0 Mouse 7.6 pIC50 = 7.6 Binding
Evaluated for inhibition of [125I]CCK-8S binding to cholecystokinin CCK-B receptor from mouse brain membranes at a concentration of 10 uM (in vitro)Evaluated for inhibition of [125I]CCK-8S binding to cholecystokinin CCK-B receptor from mouse brain membranes at a concentration of 10 uM (in vitro)
ChEMBL 423 6 1 4 5.4 CC(C)Oc1cccc(-n2c(CCc3c[nH]c4ccccc34)nc3ccccc3c2=O)c1 10.1021/jm00092a003
CHEMBL36206 130442 5 None - 0 Mouse 7.6 pIC50 = 7.6 Binding
Evaluated for inhibition of [125I]CCK-8S binding to cholecystokinin CCK-B receptor from mouse brain membranes at a concentration of 10 uM (in vitro)Evaluated for inhibition of [125I]CCK-8S binding to cholecystokinin CCK-B receptor from mouse brain membranes at a concentration of 10 uM (in vitro)
ChEMBL 423 6 1 4 5.4 CC(C)Oc1cccc(-n2c(CCc3c[nH]c4ccccc34)nc3ccccc3c2=O)c1 10.1021/jm00092a003
195737 130442 5 None - 0 Mouse 7.6 pIC50 = 7.6 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 423 6 1 4 5.4 CC(C)Oc1cccc(-n2c(CCc3c[nH]c4ccccc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
CHEMBL36206 130442 5 None - 0 Mouse 7.6 pIC50 = 7.6 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 423 6 1 4 5.4 CC(C)Oc1cccc(-n2c(CCc3c[nH]c4ccccc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
10252412 32544 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 435 3 2 4 4.2 CN1C(=O)C(NC(=O)Nc2ccc3ccccc3n2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL135289 32544 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 435 3 2 4 4.2 CN1C(=O)C(NC(=O)Nc2ccc3ccccc3n2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
11753772 32763 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 455 6 2 4 3.9 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CCN(C)C)C2=O)c1 10.1021/jm00078a018
CHEMBL135447 32763 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 455 6 2 4 3.9 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CCN(C)C)C2=O)c1 10.1021/jm00078a018
10047411 35378 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 414 4 2 4 3.7 COc1ccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc1 10.1021/jm00078a018
CHEMBL137684 35378 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 414 4 2 4 3.7 COc1ccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc1 10.1021/jm00078a018
44356726 123560 8 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 428 3 2 5 3.4 CN1C(=O)C(NC(=O)Nc2ccc3c(c2)OCO3)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL337733 123560 8 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 428 3 2 5 3.4 CN1C(=O)C(NC(=O)Nc2ccc3c(c2)OCO3)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
10767360 212624 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 489 5 2 4 5.2 CCCN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C([C@H]2CCC(C)(C)CCN2C)c2ccccc21 10.1021/jm9608523
CHEMBL83591 212624 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 489 5 2 4 5.2 CCCN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C([C@H]2CCC(C)(C)CCN2C)c2ccccc21 10.1021/jm9608523
44281020 123422 0 None - 1 Human 7.6 pIC50 = 7.6 Binding
Inhibitory activity against gastrin receptor.Inhibitory activity against gastrin receptor.
ChEMBL 773 16 4 8 6.2 CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
CHEMBL33698 123422 0 None - 1 Human 7.6 pIC50 = 7.6 Binding
Inhibitory activity against gastrin receptor.Inhibitory activity against gastrin receptor.
ChEMBL 773 16 4 8 6.2 CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
15282007 175087 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligandBinding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligand
ChEMBL 472 5 3 5 3.7 Cc1cccc(NC(=O)NC2N=C(c3c[nH]cn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1016/0960-894X(95)00557-A
CHEMBL434126 175087 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligandBinding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligand
ChEMBL 472 5 3 5 3.7 Cc1cccc(NC(=O)NC2N=C(c3c[nH]cn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1016/0960-894X(95)00557-A
5311205 19866 1 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.
ChEMBL 445 2 2 4 4.0 Cc1cccc(NC(=O)N[C@H]2N=C(N3CC4CCC(CC4)C3)c3ccccc3N(C)C2=O)c1 10.1021/jm00032a002
CHEMBL1190319 19866 1 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.
ChEMBL 445 2 2 4 4.0 Cc1cccc(NC(=O)N[C@H]2N=C(N3CC4CCC(CC4)C3)c3ccccc3N(C)C2=O)c1 10.1021/jm00032a002
CHEMBL540596 19866 1 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.
ChEMBL 445 2 2 4 4.0 Cc1cccc(NC(=O)N[C@H]2N=C(N3CC4CCC(CC4)C3)c3ccccc3N(C)C2=O)c1 10.1021/jm00032a002
904 9800 10 None - 1 Mouse 6.6 pIC50 = 6.6 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1021/jm00057a005
9915756 9800 10 None - 1 Mouse 6.6 pIC50 = 6.6 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1021/jm00057a005
CHEMBL2111204 9800 10 None - 1 Mouse 6.6 pIC50 = 6.6 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1021/jm00057a005
CHEMBL356898 9800 10 None - 1 Mouse 6.6 pIC50 = 6.6 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1021/jm00057a005
CHEMBL3142692 217911 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL None None None CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1cccc(Cl)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
15689727 113370 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity towards cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity towards cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 880 20 9 8 4.6 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccc(Cl)cc1Cl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
CHEMBL3142690 113370 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity towards cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity towards cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 880 20 9 8 4.6 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccc(Cl)cc1Cl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
44381925 19624 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortexDisplacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortex
ChEMBL 538 11 2 4 4.5 CCN(CC)CCNC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1016/S0960-894X(00)80681-2
CHEMBL1188615 19624 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortexDisplacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortex
ChEMBL 538 11 2 4 4.5 CCN(CC)CCNC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1016/S0960-894X(00)80681-2
CHEMBL536938 19624 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortexDisplacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortex
ChEMBL 538 11 2 4 4.5 CCN(CC)CCNC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1016/S0960-894X(00)80681-2
13809511 109071 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 512 6 2 5 4.1 CN1C(=O)C(NC(=O)[C@@H](Cc2ccccc2)NC(=O)OC(C)(C)C)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
CHEMBL303386 109071 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 512 6 2 5 4.1 CN1C(=O)C(NC(=O)[C@@H](Cc2ccccc2)NC(=O)OC(C)(C)C)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
10524785 214358 0 None - 0 Mouse 6.6 pIC50 = 6.6 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 396 4 3 6 3.4 N#Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2ccccc2)c1 10.1021/jm970373j
CHEMBL9492 214358 0 None - 0 Mouse 6.6 pIC50 = 6.6 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 396 4 3 6 3.4 N#Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2ccccc2)c1 10.1021/jm970373j
44283081 106647 0 None - 0 Mouse 5.6 pIC50 = 5.6 Binding
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 500 9 3 3 6.4 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(O)CCCc1ccccc1 10.1021/jm00086a017
CHEMBL2112071 106647 0 None - 0 Mouse 5.6 pIC50 = 5.6 Binding
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 500 9 3 3 6.4 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(O)CCCc1ccccc1 10.1021/jm00086a017
CHEMBL285880 106647 0 None - 0 Mouse 5.6 pIC50 = 5.6 Binding
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 500 9 3 3 6.4 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(O)CCCc1ccccc1 10.1021/jm00086a017
10721792 174565 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8
ChEMBL 571 7 1 4 6.3 CC(C)N(C(=O)CN1C(=O)C(C)(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/jm960249k
CHEMBL430451 174565 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8
ChEMBL 571 7 1 4 6.3 CC(C)N(C(=O)CN1C(=O)C(C)(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/jm960249k
20063261 29897 14 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 412 3 2 3 4.3 Cc1cc(C)cc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
CHEMBL133087 29897 14 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 412 3 2 3 4.3 Cc1cc(C)cc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
44280893 106012 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 652 13 4 5 5.0 CC(C)(C)CCNC(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL281671 106012 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 652 13 4 5 5.0 CC(C)(C)CCNC(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
10625001 35951 0 None - 0 Mouse 6.6 pIC50 = 6.6 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 493 7 4 4 4.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1(CO)CCCC1 10.1021/jm970065l
CHEMBL138190 35951 0 None - 0 Mouse 6.6 pIC50 = 6.6 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 493 7 4 4 4.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1(CO)CCCC1 10.1021/jm970065l
CHEMBL383458 219092 0 None -4 4 Human 5.6 pIC50 = 5.6 Binding
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm050921q
73354294 113745 0 None - 0 Mouse 7.6 pIC50 = 7.6 Binding
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 636 11 6 5 4.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CP(=O)(O)O)c1ccccc1 10.1021/jm00092a007
CHEMBL315055 113745 0 None - 0 Mouse 7.6 pIC50 = 7.6 Binding
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 636 11 6 5 4.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CP(=O)(O)O)c1ccccc1 10.1021/jm00092a007
19756868 35190 2 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 409 3 2 4 3.5 CN1C(=O)C(NC(=O)Nc2cccc(C#N)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL137520 35190 2 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 409 3 2 4 3.5 CN1C(=O)C(NC(=O)Nc2cccc(C#N)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
44281078 106519 0 None - 1 Human 7.6 pIC50 = 7.6 Binding
Inhibitory activity against gastrin receptor.Inhibitory activity against gastrin receptor.
ChEMBL 773 16 4 8 5.9 CN1C(=O)[C@H](NC(=O)Nc2cccc(CCOC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
CHEMBL284975 106519 0 None - 1 Human 7.6 pIC50 = 7.6 Binding
Inhibitory activity against gastrin receptor.Inhibitory activity against gastrin receptor.
ChEMBL 773 16 4 8 5.9 CN1C(=O)[C@H](NC(=O)Nc2cccc(CCOC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
CHEMBL318475 217992 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL None None None CC(C)(C)OC(=O)N1c2ccccc2C[C@@H]1C(=O)N1[C@H](c2ccccc2)CC[C@@H]1C(=O)N1Cc2ccccc2C[C@@H]1C(=O)NCC(=O)O 10.1016/S0960-894X(96)00546-X
44210425 172073 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 439 5 2 5 3.5 COc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)OC(C)(C)C)C2=O)c1 10.1016/S0960-894X(00)80683-6
CHEMBL423278 172073 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 439 5 2 5 3.5 COc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)OC(C)(C)C)C2=O)c1 10.1016/S0960-894X(00)80683-6
10626598 58551 0 None - 0 Mouse 6.6 pIC50 = 6.6 Binding
Compound was tested for the inhibition of specific binding of [125I]bolton Hunter CCK-8 to Cholecystokinin type B receptor in mouse cerebral cortexCompound was tested for the inhibition of specific binding of [125I]bolton Hunter CCK-8 to Cholecystokinin type B receptor in mouse cerebral cortex
ChEMBL 555 8 3 5 5.4 COC(=O)/C(=C/c1ccccc1)NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1016/S0960-894X(01)81250-6
CHEMBL158491 58551 0 None - 0 Mouse 6.6 pIC50 = 6.6 Binding
Compound was tested for the inhibition of specific binding of [125I]bolton Hunter CCK-8 to Cholecystokinin type B receptor in mouse cerebral cortexCompound was tested for the inhibition of specific binding of [125I]bolton Hunter CCK-8 to Cholecystokinin type B receptor in mouse cerebral cortex
ChEMBL 555 8 3 5 5.4 COC(=O)/C(=C/c1ccccc1)NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1016/S0960-894X(01)81250-6
44333341 114563 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortexDisplacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortex
ChEMBL 448 4 2 5 2.9 CCCN1C(=O)[C@@H](NC(=O)Nc2cccc(C)c2)N=C(N2CCN(C)CC2)c2ccccc21 10.1016/0960-894X(95)00530-0
CHEMBL319180 114563 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortexDisplacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortex
ChEMBL 448 4 2 5 2.9 CCCN1C(=O)[C@@H](NC(=O)Nc2cccc(C)c2)N=C(N2CCN(C)CC2)c2ccccc21 10.1016/0960-894X(95)00530-0
443375 214385 45 None 2 5 Mouse 6.6 pIC50 = 6.6 Binding
Half maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortexHalf maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm000937a
CHEMBL9506 214385 45 None 2 5 Mouse 6.6 pIC50 = 6.6 Binding
Half maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortexHalf maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm000937a
5279169 32971 1 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 404 3 3 3 4.3 O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2NC1=O 10.1021/jm00078a018
CHEMBL135715 32971 1 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 404 3 3 3 4.3 O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2NC1=O 10.1021/jm00078a018
44381949 127502 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Tested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brainTested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL 474 3 3 4 4.6 CN1C(=O)[C@H](NC(=O)Nc2cc3c4ccccc4nc-3c[nH]2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80682-4
CHEMBL354802 127502 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Tested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brainTested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL 474 3 3 4 4.6 CN1C(=O)[C@H](NC(=O)Nc2cc3c4ccccc4nc-3c[nH]2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80682-4
443375 214385 45 None -316 5 Human 6.6 pIC50 = 6.6 Binding
The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain at a pH of 6.5The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain at a pH of 6.5
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80684-8
CHEMBL9506 214385 45 None -316 5 Human 6.6 pIC50 = 6.6 Binding
The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain at a pH of 6.5The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain at a pH of 6.5
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80684-8
9985667 170140 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
In vitro inhibition of [3H]propionyl-CCK-8 binding to rat cerebral cortex membranes at Cholecystokinin type B receptor.In vitro inhibition of [3H]propionyl-CCK-8 binding to rat cerebral cortex membranes at Cholecystokinin type B receptor.
ChEMBL 580 9 4 5 3.9 O=C(O)C[C@@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@H]2C[C@H](NC(=O)OCc3ccccc3)C(=O)N12 10.1021/jm000959x
CHEMBL419237 170140 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
In vitro inhibition of [3H]propionyl-CCK-8 binding to rat cerebral cortex membranes at Cholecystokinin type B receptor.In vitro inhibition of [3H]propionyl-CCK-8 binding to rat cerebral cortex membranes at Cholecystokinin type B receptor.
ChEMBL 580 9 4 5 3.9 O=C(O)C[C@@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@H]2C[C@H](NC(=O)OCc3ccccc3)C(=O)N12 10.1021/jm000959x
9985667 170140 0 None - 0 Mouse 5.6 pIC50 = 5.6 Binding
Inhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptorInhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptor
ChEMBL 580 9 4 5 3.9 O=C(O)C[C@@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@H]2C[C@H](NC(=O)OCc3ccccc3)C(=O)N12 10.1016/s0960-894x(98)00677-5
CHEMBL419237 170140 0 None - 0 Mouse 5.6 pIC50 = 5.6 Binding
Inhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptorInhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptor
ChEMBL 580 9 4 5 3.9 O=C(O)C[C@@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@H]2C[C@H](NC(=O)OCc3ccccc3)C(=O)N12 10.1016/s0960-894x(98)00677-5
14991568 107487 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 847 20 8 8 4.0 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1ccc2ccccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL292519 107487 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 847 20 8 8 4.0 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1ccc2ccccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
44349298 23400 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 429 8 3 4 3.5 CC(C)c1ccc(C(=O)NC(CCC(=O)O)C(=O)NN2CCC3(CCCC3)CC2)cc1 10.1021/jm00079a003
CHEMBL124155 23400 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 429 8 3 4 3.5 CC(C)c1ccc(C(=O)NC(CCC(=O)O)C(=O)NN2CCC3(CCCC3)CC2)cc1 10.1021/jm00079a003
CHEMBL328422 218075 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Displacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL None None None Cc1cccc(C)c1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00173a006
15104598 116560 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 481 13 2 2 6.4 CCCCCN(CCCCC)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccc(Cl)cc1 10.1021/jm00116a002
CHEMBL323245 116560 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 481 13 2 2 6.4 CCCCCN(CCCCC)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccc(Cl)cc1 10.1021/jm00116a002
52949124 7663 4 None 2 2 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I-CCK] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-CCK] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
9055 7663 4 None 2 2 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I-CCK] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-CCK] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
CHEMBL1269258 7663 4 None 2 2 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I-CCK] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-CCK] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
DB12694 7663 4 None 2 2 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I-CCK] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-CCK] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
44396745 131816 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
Inhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenatesInhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenates
ChEMBL 623 8 2 6 5.5 CN(C)c1ccc(N2C(=O)CC3[C@H](N[C@@H](Cc4c[nH]c5ccccc45)C(=O)OC4C5CC6CC(C5)CC4C6)CCCN3C2=O)cc1 10.1021/jm0498755
CHEMBL364334 131816 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
Inhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenatesInhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenates
ChEMBL 623 8 2 6 5.5 CN(C)c1ccc(N2C(=O)CC3[C@H](N[C@@H](Cc4c[nH]c5ccccc45)C(=O)OC4C5CC6CC(C5)CC4C6)CCCN3C2=O)cc1 10.1021/jm0498755
44329324 114094 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 594 7 3 3 7.2 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)Nc3ccc(Cl)cc3)C2=O)c1 10.1016/S0960-894X(01)80832-5
CHEMBL317366 114094 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 594 7 3 3 7.2 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)Nc3ccc(Cl)cc3)C2=O)c1 10.1016/S0960-894X(01)80832-5
14208225 74528 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 426 3 2 3 3.9 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL1907855 74528 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 426 3 2 3 3.9 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
14843049 107255 0 None - 0 Mouse 7.6 pIC50 = 7.6 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 471 5 1 3 6.0 CCc1ccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)cc1 10.1021/jm00108a040
CHEMBL290897 107255 0 None - 0 Mouse 7.6 pIC50 = 7.6 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 471 5 1 3 6.0 CCc1ccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)cc1 10.1021/jm00108a040
44329519 115064 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 594 6 3 3 6.6 Cc1ccccc1[C@H]1C[C@@H](NC(=O)Nc2cccc(C(F)(F)F)c2)C(=O)N(CC(=O)NC(C)(C)C)[C@@H](c2ccccc2)C1 10.1016/S0960-894X(01)80832-5
CHEMBL319748 115064 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 594 6 3 3 6.6 Cc1ccccc1[C@H]1C[C@@H](NC(=O)Nc2cccc(C(F)(F)F)c2)C(=O)N(CC(=O)NC(C)(C)C)[C@@H](c2ccccc2)C1 10.1016/S0960-894X(01)80832-5
44329363 115481 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 594 7 3 3 7.2 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)Nc3ccccc3Cl)C2=O)c1 10.1016/S0960-894X(01)80832-5
CHEMBL320821 115481 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 594 7 3 3 7.2 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)Nc3ccccc3Cl)C2=O)c1 10.1016/S0960-894X(01)80832-5
44329384 215110 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 556 7 3 4 5.6 COc1ccccc1[C@H]1C[C@@H](NC(=O)Nc2cccc(C)c2)C(=O)N(CC(=O)NC(C)(C)C)[C@@H](c2ccccc2)C1 10.1016/S0960-894X(01)80832-5
CHEMBL99289 215110 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 556 7 3 4 5.6 COc1ccccc1[C@H]1C[C@@H](NC(=O)Nc2cccc(C)c2)C(=O)N(CC(=O)NC(C)(C)C)[C@@H](c2ccccc2)C1 10.1016/S0960-894X(01)80832-5
10477146 85288 1 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 418 3 2 3 4.3 CN1C(=O)[C@@H](NC(=O)Nc2ccccc2Cl)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL2111920 85288 1 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 418 3 2 3 4.3 CN1C(=O)[C@@H](NC(=O)Nc2ccccc2Cl)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
9887120 210905 4 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
CHEMBL70380 210905 4 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
44211353 65827 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortexDisplacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortex
ChEMBL 552 9 2 5 3.5 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NCCN1CCOCC1 10.1016/S0960-894X(00)80681-2
CHEMBL169453 65827 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortexDisplacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortex
ChEMBL 552 9 2 5 3.5 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NCCN1CCOCC1 10.1016/S0960-894X(00)80681-2
15719750 85258 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 446 9 3 3 4.0 O=C(O)CC[C@H](NC(=O)c1cccc(Cl)c1)C(=O)NCCC12CC3CC(CC(C3)C1)C2 10.1021/jm00079a003
CHEMBL2111825 85258 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 446 9 3 3 4.0 O=C(O)CC[C@H](NC(=O)c1cccc(Cl)c1)C(=O)NCCC12CC3CC(CC(C3)C1)C2 10.1021/jm00079a003
10156187 109883 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 373 3 2 3 3.4 O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccccc1 10.1021/jm00120a002
CHEMBL307659 109883 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 373 3 2 3 3.4 O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccccc1 10.1021/jm00120a002
44349277 120825 0 None - 0 Rat 4.6 pIC50 = 4.6 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 382 12 3 3 3.4 CCCCCCCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 10.1021/jm00079a003
CHEMBL332674 120825 0 None - 0 Rat 4.6 pIC50 = 4.6 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 382 12 3 3 3.4 CCCCCCCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 10.1021/jm00079a003
10531224 174780 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligandBinding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligand
ChEMBL 575 7 2 4 5.7 CC(C)N(C(=O)CN1C(=O)C(C)(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/jm960205b
CHEMBL432015 174780 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligandBinding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligand
ChEMBL 575 7 2 4 5.7 CC(C)N(C(=O)CN1C(=O)C(C)(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/jm960205b
10531224 174780 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]Bolton-Hunter CCK8 from human Cholecystokinin B receptor expressed in CHO-K1 cells by competitive radioligand binding assayDisplacement of [125I]Bolton-Hunter CCK8 from human Cholecystokinin B receptor expressed in CHO-K1 cells by competitive radioligand binding assay
ChEMBL 575 7 2 4 5.7 CC(C)N(C(=O)CN1C(=O)C(C)(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/acs.jmedchem.0c00829
CHEMBL432015 174780 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]Bolton-Hunter CCK8 from human Cholecystokinin B receptor expressed in CHO-K1 cells by competitive radioligand binding assayDisplacement of [125I]Bolton-Hunter CCK8 from human Cholecystokinin B receptor expressed in CHO-K1 cells by competitive radioligand binding assay
ChEMBL 575 7 2 4 5.7 CC(C)N(C(=O)CN1C(=O)C(C)(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/acs.jmedchem.0c00829
44303526 209923 0 None - 0 Mouse 5.6 pIC50 = 5.6 Binding
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 708 14 4 6 6.3 O=C(CCC(=O)OCc1ccccc1)N[C@@H](CNC(=O)C(Cc1c[nH]c2ccc(F)cc12)NC(=O)OC1C2CC3CC(C2)CC1C3)c1ccccc1 10.1016/S0960-894X(97)00356-9
CHEMBL64155 209923 0 None - 0 Mouse 5.6 pIC50 = 5.6 Binding
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 708 14 4 6 6.3 O=C(CCC(=O)OCc1ccccc1)N[C@@H](CNC(=O)C(Cc1c[nH]c2ccc(F)cc12)NC(=O)OC1C2CC3CC(C2)CC1C3)c1ccccc1 10.1016/S0960-894X(97)00356-9
10528465 103825 0 None - 0 Mouse 7.5 pIC50 = 7.5 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 473 7 4 7 4.0 CC(C)Oc1cccc(-n2c(NNC(=O)Nc3cccc(C(=O)O)c3)nc3ccccc3c2=O)c1 10.1021/jm970373j
CHEMBL267023 103825 0 None - 0 Mouse 7.5 pIC50 = 7.5 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 473 7 4 7 4.0 CC(C)Oc1cccc(-n2c(NNC(=O)Nc3cccc(C(=O)O)c3)nc3ccccc3c2=O)c1 10.1021/jm970373j
5311201 214174 35 None -26 6 Mouse 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
5311201 214174 35 None -26 6 Mouse 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00249-1
CHEMBL9387 214174 35 None -26 6 Mouse 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL9387 214174 35 None -26 6 Mouse 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00249-1
5311201 214174 35 None -27 6 Human 7.5 pIC50 = 7.5 Binding
Inhibitory concentration against Cholecystokinin B receptorInhibitory concentration against Cholecystokinin B receptor
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm058225d
CHEMBL9387 214174 35 None -27 6 Human 7.5 pIC50 = 7.5 Binding
Inhibitory concentration against Cholecystokinin B receptorInhibitory concentration against Cholecystokinin B receptor
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm058225d
11540160 78223 0 None - 3 Dog 7.5 pIC50 = 7.5 Binding
Concentration required to inhibit the binding of [125I]-BH-CCK-8S radioligand to canine gastric mucosa CCK2 receptorConcentration required to inhibit the binding of [125I]-BH-CCK-8S radioligand to canine gastric mucosa CCK2 receptor
ChEMBL 475 7 3 3 6.6 O=C(O)c1cccc(NC(=O)c2[nH]c(C3CCCCC3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
CHEMBL196133 78223 0 None - 3 Dog 7.5 pIC50 = 7.5 Binding
Concentration required to inhibit the binding of [125I]-BH-CCK-8S radioligand to canine gastric mucosa CCK2 receptorConcentration required to inhibit the binding of [125I]-BH-CCK-8S radioligand to canine gastric mucosa CCK2 receptor
ChEMBL 475 7 3 3 6.6 O=C(O)c1cccc(NC(=O)c2[nH]c(C3CCCCC3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
44300550 107673 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
In vitro test for inhibition of [125I]CCK binding to Cholecystokinin type B receptor from guinea pig cortical membranes was determinedIn vitro test for inhibition of [125I]CCK binding to Cholecystokinin type B receptor from guinea pig cortical membranes was determined
ChEMBL 376 3 2 3 3.7 Cc1cccc(NC(=O)NC2N=C(C3CCC3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(01)80987-2
CHEMBL293786 107673 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
In vitro test for inhibition of [125I]CCK binding to Cholecystokinin type B receptor from guinea pig cortical membranes was determinedIn vitro test for inhibition of [125I]CCK binding to Cholecystokinin type B receptor from guinea pig cortical membranes was determined
ChEMBL 376 3 2 3 3.7 Cc1cccc(NC(=O)NC2N=C(C3CCC3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(01)80987-2
44279811 103700 0 None - 1 Mouse 6.5 pIC50 = 6.5 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 743 15 4 7 5.3 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
CHEMBL265987 103700 0 None - 1 Mouse 6.5 pIC50 = 6.5 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 743 15 4 7 5.3 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
44280372 106163 0 None - 1 Mouse 6.5 pIC50 = 6.5 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 787 17 4 8 5.8 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL282645 106163 0 None - 1 Mouse 6.5 pIC50 = 6.5 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 787 17 4 8 5.8 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
44403829 78227 0 None - 1 Human 6.5 pIC50 = 6.5 Binding
Inhibitory concentration against Cholecystokinin B receptorInhibitory concentration against Cholecystokinin B receptor
ChEMBL 743 15 4 7 5.3 CN1C(=O)[C@H](NC(=O)Nc2ccc(CC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm058225d
CHEMBL196143 78227 0 None - 1 Human 6.5 pIC50 = 6.5 Binding
Inhibitory concentration against Cholecystokinin B receptorInhibitory concentration against Cholecystokinin B receptor
ChEMBL 743 15 4 7 5.3 CN1C(=O)[C@H](NC(=O)Nc2ccc(CC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm058225d
15689736 113377 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 862 20 9 8 4.5 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC/N=C(\S)Nc1ccccc1Cl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
CHEMBL3142702 113377 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 862 20 9 8 4.5 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC/N=C(\S)Nc1ccccc1Cl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
14208241 74525 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 421 3 1 3 4.0 CN1C(=O)[C@@H](NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00121a004
CHEMBL1907852 74525 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 421 3 1 3 4.0 CN1C(=O)[C@@H](NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00121a004
14208221 86323 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 530 6 2 5 4.2 CN1C(=O)C(NC(=O)C(Cc2ccccc2)NC(=O)OC(C)(C)C)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL2114102 86323 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 530 6 2 5 4.2 CN1C(=O)C(NC(=O)C(Cc2ccccc2)NC(=O)OC(C)(C)C)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
10454890 161921 1 None - 0 Human 5.5 pIC50 = 5.5 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 421 3 1 3 4.0 CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL40211 161921 1 None - 0 Human 5.5 pIC50 = 5.5 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 421 3 1 3 4.0 CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
90663986 113593 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 857 21 8 8 3.9 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(Cl)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL3144555 113593 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 857 21 8 8 3.9 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(Cl)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
44349326 23536 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 402 8 3 3 3.5 CC(C)(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1Cl 10.1021/jm00079a003
CHEMBL124378 23536 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 402 8 3 3 3.5 CC(C)(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1Cl 10.1021/jm00079a003
14208244 65642 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain at a pH of 6.5The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain at a pH of 6.5
ChEMBL 403 3 1 3 3.9 CN1C(=O)[C@@H](NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80684-8
CHEMBL168852 65642 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain at a pH of 6.5The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain at a pH of 6.5
ChEMBL 403 3 1 3 3.9 CN1C(=O)[C@@H](NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80684-8
14208215 110577 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 405 3 2 3 4.4 O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1cccc2ccccc12 10.1021/jm00120a002
CHEMBL309017 110577 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 405 3 2 3 4.4 O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1cccc2ccccc12 10.1021/jm00120a002
14208234 211478 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 428 3 4 4 3.6 O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1cc2cc(O)ccc2[nH]1 10.1021/jm00120a002
CHEMBL74066 211478 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 428 3 4 4 3.6 O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1cc2cc(O)ccc2[nH]1 10.1021/jm00120a002
44280179 109798 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 601 11 3 4 5.3 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(CCc1ccccc1)C(=O)O 10.1021/jm950372w
CHEMBL30696 109798 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 601 11 3 4 5.3 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(CCc1ccccc1)C(=O)O 10.1021/jm950372w
44283500 146041 0 None - 0 Mouse 5.5 pIC50 = 5.5 Binding
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 516 9 3 5 4.8 O=C(NC(Cc1c[nH]c2ccccc12)C(=O)OC(CO)Cc1ccccc1)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
CHEMBL37903 146041 0 None - 0 Mouse 5.5 pIC50 = 5.5 Binding
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 516 9 3 5 4.8 O=C(NC(Cc1c[nH]c2ccccc12)C(=O)OC(CO)Cc1ccccc1)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
10817241 113899 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 591 8 1 5 5.6 COc1ccc(N(C(=O)CN2C(=O)C(Cc3[nH]nc4c3CCCC4)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm970265x
CHEMBL316077 113899 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 591 8 1 5 5.6 COc1ccc(N(C(=O)CN2C(=O)C(Cc3[nH]nc4c3CCCC4)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm970265x
10555804 118375 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 616 9 1 5 6.3 COc1ccc(N(C(=O)CN2C(=O)C(Cc3c[nH]c4ccccc34)(OC)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm970265x
CHEMBL328285 118375 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 616 9 1 5 6.3 COc1ccc(N(C(=O)CN2C(=O)C(Cc3c[nH]c4ccccc34)(OC)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm970265x
44280895 174875 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 652 15 3 5 5.1 CCCN(CCC)C(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL432679 174875 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 652 15 3 5 5.1 CCCN(CCC)C(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL274661 217594 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Inhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic aciniInhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic acini
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)OCCc1ccccc1 10.1021/jm00072a024
10409534 35012 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 414 4 2 4 3.7 COc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
CHEMBL137398 35012 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 414 4 2 4 3.7 COc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
44280252 106629 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 655 11 5 8 3.7 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCSCc3csc(N=C(N)N)n3)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL285746 106629 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 655 11 5 8 3.7 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCSCc3csc(N=C(N)N)n3)C2=O)c1 10.1016/S0960-894X(96)00248-X
11799359 35824 0 None - 0 Mouse 8.5 pIC50 = 8.5 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 493 6 4 4 4.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H]1CCCC[C@H]1O 10.1021/jm970065l
CHEMBL138084 35824 0 None - 0 Mouse 8.5 pIC50 = 8.5 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 493 6 4 4 4.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H]1CCCC[C@H]1O 10.1021/jm970065l
104929 9000 9 None 51 3 Human 8.5 pIC50 = 8.5 Binding
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 10.1021/jm00121a004
3477 9000 9 None 51 3 Human 8.5 pIC50 = 8.5 Binding
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 10.1021/jm00121a004
879 9000 9 None 51 3 Human 8.5 pIC50 = 8.5 Binding
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 10.1021/jm00121a004
CHEMBL289498 9000 9 None 51 3 Human 8.5 pIC50 = 8.5 Binding
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 10.1021/jm00121a004
15667016 92893 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 960 25 9 11 1.0 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
CHEMBL2310856 92893 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 960 25 9 11 1.0 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
14888734 174625 0 None - 0 Bovine 8.5 pIC50 = 8.5 Binding
Inhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranesInhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranes
ChEMBL 1012 29 10 13 0.8 CSCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00107a037
CHEMBL430906 174625 0 None - 0 Bovine 8.5 pIC50 = 8.5 Binding
Inhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranesInhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranes
ChEMBL 1012 29 10 13 0.8 CSCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00107a037
CHEMBL5288951 201229 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity to human CCK2R expressed in human A-431 cellsBinding affinity to human CCK2R expressed in human A-431 cells
ChEMBL 1201 24 15 15 0.4 CCCCC[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CCCCNC(=O)[C@H](NC(=O)c2ccc(NN)nc2)CCC(=O)N[C@@H](C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.ejmech.2021.113538
10768071 16606 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 512 6 3 5 4.3 CC(C)(C)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C(=O)O)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm960669+
CHEMBL113988 16606 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 512 6 3 5 4.3 CC(C)(C)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C(=O)O)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm960669+
10435698 148186 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 490 6 2 5 4.2 CCOC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80683-6
CHEMBL38404 148186 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 490 6 2 5 4.2 CCOC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80683-6
CHEMBL34554 218488 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cellsBinding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cells
ChEMBL None None None CCCS[C@H]1CCN(C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(C)=O)[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00001a019
10435698 148186 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 490 6 2 5 4.2 CCOC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00121a004
CHEMBL38404 148186 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 490 6 2 5 4.2 CCOC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00121a004
CHEMBL59865 222595 0 None - 1 Human 8.5 pIC50 = 8.5 Binding
Compound was tested for its binding affinity towards Cholecystokinin type B receptor in cortical membranes (CNS)Compound was tested for its binding affinity towards Cholecystokinin type B receptor in cortical membranes (CNS)
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN 10.1016/S0960-894X(01)81005-2
56666696 70791 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]CCK from gastrin receptor isolated from human tumor tissuesDisplacement of [125I]CCK from gastrin receptor isolated from human tumor tissues
ChEMBL 1450 45 14 23 -2.8 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NCCOCCOCCOCCOC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm101279a
CHEMBL1807149 70791 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]CCK from gastrin receptor isolated from human tumor tissuesDisplacement of [125I]CCK from gastrin receptor isolated from human tumor tissues
ChEMBL 1450 45 14 23 -2.8 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NCCOCCOCCOCCOC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm101279a
15667013 114183 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 920 26 10 11 0.1 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)CNC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
CHEMBL318010 114183 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 920 26 10 11 0.1 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)CNC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
14802510 121895 0 None - 0 Mouse 8.5 pIC50 = 8.5 Binding
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 629 13 4 6 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](COC(=O)CCC(=O)O)Cc1ccccc1 10.1021/jm00105a062
CHEMBL334346 121895 0 None - 0 Mouse 8.5 pIC50 = 8.5 Binding
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 629 13 4 6 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](COC(=O)CCC(=O)O)Cc1ccccc1 10.1021/jm00105a062
10051647 124063 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 498 5 3 3 5.2 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2C(C)C 10.1021/jm00048a015
CHEMBL339547 124063 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 498 5 3 3 5.2 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2C(C)C 10.1021/jm00048a015
71456223 85541 0 None - 0 Bovine 8.5 pIC50 = 8.5 Binding
Inhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatumInhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatum
ChEMBL 1006 25 11 11 1.8 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1CCCC[C@@H]1NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00099a005
CHEMBL2112635 85541 0 None - 0 Bovine 8.5 pIC50 = 8.5 Binding
Inhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatumInhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatum
ChEMBL 1006 25 11 11 1.8 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1CCCC[C@@H]1NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00099a005
44368298 127806 0 None - 0 Mouse 8.5 pIC50 = 8.5 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 613 13 4 5 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)C1C2CC3CC(C2)CC1C3)C(=O)N[C@H](COC(=O)CCC(=O)O)Cc1ccccc1 10.1021/jm00057a005
CHEMBL356599 127806 0 None - 0 Mouse 8.5 pIC50 = 8.5 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 613 13 4 5 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)C1C2CC3CC(C2)CC1C3)C(=O)N[C@H](COC(=O)CCC(=O)O)Cc1ccccc1 10.1021/jm00057a005
10481933 20068 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 524 5 2 5 3.1 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)N3CCN(C)CC3)C2=O)c1 10.1021/jm00078a018
CHEMBL1191818 20068 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 524 5 2 5 3.1 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)N3CCN(C)CC3)C2=O)c1 10.1021/jm00078a018
CHEMBL542967 20068 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 524 5 2 5 3.1 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)N3CCN(C)CC3)C2=O)c1 10.1021/jm00078a018
10673078 35860 0 None - 0 Mouse 8.5 pIC50 = 8.5 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 502 6 3 4 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1CCCCC1C#N 10.1021/jm970065l
CHEMBL138112 35860 0 None - 0 Mouse 8.5 pIC50 = 8.5 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 502 6 3 4 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1CCCCC1C#N 10.1021/jm970065l
CHEMBL1806528 215753 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]CCK from gastrin receptor isolated from human tumor tissuesDisplacement of [125I]CCK from gastrin receptor isolated from human tumor tissues
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm101279a
54695534 10561 5 None - 0 Rat 8.4 pIC50 = 8.4 Binding
Inhibition of CCK-B receptor in rat cerebral cortexInhibition of CCK-B receptor in rat cerebral cortex
ChEMBL 570 2 3 8 4.5 OC1C/C=C/CC(C)C2C(SCC2C(=O)C2=C(OC3(C(C/C=C/C=C/C1)C=C(C)C(C3)C)C2=O)O)C(=O)C(=O)O 10.1021/np500757w
910 10561 5 None - 0 Rat 8.4 pIC50 = 8.4 Binding
Inhibition of CCK-B receptor in rat cerebral cortexInhibition of CCK-B receptor in rat cerebral cortex
ChEMBL 570 2 3 8 4.5 OC1C/C=C/CC(C)C2C(SCC2C(=O)C2=C(OC3(C(C/C=C/C=C/C1)C=C(C)C(C3)C)C2=O)O)C(=O)C(=O)O 10.1021/np500757w
CHEMBL3576924 10561 5 None - 0 Rat 8.4 pIC50 = 8.4 Binding
Inhibition of CCK-B receptor in rat cerebral cortexInhibition of CCK-B receptor in rat cerebral cortex
ChEMBL 570 2 3 8 4.5 OC1C/C=C/CC(C)C2C(SCC2C(=O)C2=C(OC3(C(C/C=C/C=C/C1)C=C(C)C(C3)C)C2=O)O)C(=O)C(=O)O 10.1021/np500757w
104929 9000 9 None -165 3 Rat 8.4 pIC50 = 8.4 Binding
Displacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting methodDisplacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting method
ChEMBL 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 10.1039/C7MD00171A
3477 9000 9 None -165 3 Rat 8.4 pIC50 = 8.4 Binding
Displacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting methodDisplacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting method
ChEMBL 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 10.1039/C7MD00171A
879 9000 9 None -165 3 Rat 8.4 pIC50 = 8.4 Binding
Displacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting methodDisplacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting method
ChEMBL 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 10.1039/C7MD00171A
CHEMBL289498 9000 9 None -165 3 Rat 8.4 pIC50 = 8.4 Binding
Displacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting methodDisplacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting method
ChEMBL 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 10.1039/C7MD00171A
10347746 23573 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 558 6 3 3 6.2 CC1(NC(=O)CN2C(=O)[C@H](NC(=O)Nc3cccc(Cl)c3)C[C@H](c3ccccc3)c3ccccc32)CCCCC1 10.1021/jm00048a015
CHEMBL124611 23573 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 558 6 3 3 6.2 CC1(NC(=O)CN2C(=O)[C@H](NC(=O)Nc3cccc(Cl)c3)C[C@H](c3ccccc3)c3ccccc32)CCCCC1 10.1021/jm00048a015
10029582 33938 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 517 7 2 4 4.5 CCN(CC)C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2Cl)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL136608 33938 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 517 7 2 4 4.5 CCN(CC)C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2Cl)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
10004579 85291 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 462 3 2 3 4.4 CN1C(=O)[C@H](NC(=O)Nc2cccc(Br)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL2111923 85291 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 462 3 2 3 4.4 CN1C(=O)[C@H](NC(=O)Nc2cccc(Br)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
43811299 123438 13 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 452 3 2 3 4.7 CN1C(=O)C(NC(=O)Nc2cccc(C(F)(F)F)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL337055 123438 13 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 452 3 2 3 4.7 CN1C(=O)C(NC(=O)Nc2cccc(C(F)(F)F)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL408330 219484 0 None -1 3 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](CCCC)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
44373740 126670 0 None - 0 Mouse 8.4 pIC50 = 8.4 Binding
Compound was tested for the inhibition of specific binding of [125I]bolton Hunter CCK-8 to Cholecystokinin type B receptor in mouse cerebral cortexCompound was tested for the inhibition of specific binding of [125I]bolton Hunter CCK-8 to Cholecystokinin type B receptor in mouse cerebral cortex
ChEMBL 569 8 3 5 5.2 COC(=O)[C@@]1(NC(=O)[C@@](C)(Cc2c[nH]c3ccccc23)NC(=O)OC2C3CC4CC(C3)CC2C4)C[C@H]1c1ccccc1 10.1016/S0960-894X(01)81250-6
CHEMBL349079 126670 0 None - 0 Mouse 8.4 pIC50 = 8.4 Binding
Compound was tested for the inhibition of specific binding of [125I]bolton Hunter CCK-8 to Cholecystokinin type B receptor in mouse cerebral cortexCompound was tested for the inhibition of specific binding of [125I]bolton Hunter CCK-8 to Cholecystokinin type B receptor in mouse cerebral cortex
ChEMBL 569 8 3 5 5.2 COC(=O)[C@@]1(NC(=O)[C@@](C)(Cc2c[nH]c3ccccc23)NC(=O)OC2C3CC4CC(C3)CC2C4)C[C@H]1c1ccccc1 10.1016/S0960-894X(01)81250-6
44368521 53068 0 None - 0 Mouse 8.4 pIC50 = 8.4 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 576 12 5 5 4.6 C[C@H]1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1 10.1021/jm00057a005
CHEMBL153557 53068 0 None - 0 Mouse 8.4 pIC50 = 8.4 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 576 12 5 5 4.6 C[C@H]1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1 10.1021/jm00057a005
CHEMBL2372294 216991 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cellsBinding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cells
ChEMBL None None None CS[C@H]1C[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)N(C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(C)=O)C1 10.1021/jm00001a019
CHEMBL34853 218494 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cellsBinding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cells
ChEMBL None None None CCS[C@H]1CCN(C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(C)=O)[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00001a019
44333048 176036 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic aciniInhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic acini
ChEMBL 1032 28 10 11 3.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 10.1021/jm00072a024
CHEMBL441165 176036 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic aciniInhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic acini
ChEMBL 1032 28 10 11 3.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 10.1021/jm00072a024
44331865 11046 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL 538 12 3 4 3.9 CCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N(CC(=O)N1CCC[C@H]1C(=O)O)CC1CCCCC1 10.1016/S0960-894X(96)00546-X
CHEMBL100604 11046 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL 538 12 3 4 3.9 CCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N(CC(=O)N1CCC[C@H]1C(=O)O)CC1CCCCC1 10.1016/S0960-894X(96)00546-X
10391769 24510 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 514 6 3 4 4.7 COc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)c3ccccc3N(CC(=O)NC(C)(C)C)C2=O)c1 10.1021/jm00048a015
CHEMBL125863 24510 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 514 6 3 4 4.7 COc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)c3ccccc3N(CC(=O)NC(C)(C)C)C2=O)c1 10.1021/jm00048a015
443375 214385 45 None -316 5 Human 6.5 pIC50 = 6.5 Binding
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80683-6
CHEMBL9506 214385 45 None -316 5 Human 6.5 pIC50 = 6.5 Binding
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80683-6
CHEMBL37983 219045 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cellsBinding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cells
ChEMBL None None None CS[C@H]1CCN(C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(C)=O)[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00001a019
443375 214385 45 None -316 5 Human 6.5 pIC50 = 6.5 Binding
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00121a004
CHEMBL9506 214385 45 None -316 5 Human 6.5 pIC50 = 6.5 Binding
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00121a004
10432393 107122 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 422 3 3 3 4.4 O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2F)c2ccccc2NC1=O 10.1021/jm00121a004
CHEMBL289533 107122 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 422 3 3 3 4.4 O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2F)c2ccccc2NC1=O 10.1021/jm00121a004
CHEMBL431116 220402 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00388a002
10341724 85290 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 414 4 2 4 3.7 COc1cccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
CHEMBL2111922 85290 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 414 4 2 4 3.7 COc1cccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
15637183 126017 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 531 7 3 5 4.1 O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(C[C@@H](O)CN2CCCC2)C1=O 10.1021/jm00078a018
CHEMBL343513 126017 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 531 7 3 5 4.1 O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(C[C@@H](O)CN2CCCC2)C1=O 10.1021/jm00078a018
14991570 209594 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 943 22 9 11 3.2 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1ccc2cc(OS(=O)(=O)O)ccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL62345 209594 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 943 22 9 11 3.2 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1ccc2cc(OS(=O)(=O)O)ccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
44349383 23539 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 480 9 3 3 4.7 O=C(O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)NCCC12CC3CC(CC(C3)C1)C2 10.1021/jm00079a003
CHEMBL124396 23539 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 480 9 3 3 4.7 O=C(O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)NCCC12CC3CC(CC(C3)C1)C2 10.1021/jm00079a003
44349028 124000 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 437 7 3 4 3.5 O=C(O)CCC(NC(=O)c1ccc2ccccc2c1)C(=O)NN1CCC2(CCCC2)CC1 10.1021/jm00079a003
CHEMBL339453 124000 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 437 7 3 4 3.5 O=C(O)CCC(NC(=O)c1ccc2ccccc2c1)C(=O)NN1CCC2(CCCC2)CC1 10.1021/jm00079a003
CHEMBL285995 106668 0 None - 1 Mouse 6.5 pIC50 = 6.5 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 741 16 6 11 4.5 CN1C(=O)[C@H](NC(=O)Nc2cccc(CCOC(=O)NCCCNCCSCc3csc(C=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
44334704 11390 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 499 9 2 4 4.8 Cc1cccc(NC(=O)N[C@H](COCc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
CHEMBL102862 11390 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 499 9 2 4 4.8 Cc1cccc(NC(=O)N[C@H](COCc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
44332066 11287 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL 546 13 3 4 3.5 CCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N(CCc1ccccc1)CC(=O)N1CCCC1C(=O)O 10.1016/S0960-894X(96)00546-X
CHEMBL102184 11287 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL 546 13 3 4 3.5 CCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N(CCc1ccccc1)CC(=O)N1CCCC1C(=O)O 10.1016/S0960-894X(96)00546-X
15689724 113375 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 880 20 9 8 4.3 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1cccc(C(F)(F)F)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
CHEMBL3142696 113375 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 880 20 9 8 4.3 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1cccc(C(F)(F)F)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
15689726 113371 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Binding affinity towards cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity towards cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 880 20 9 8 4.6 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1cccc(Cl)c1Cl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
CHEMBL3142691 113371 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Binding affinity towards cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity towards cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 880 20 9 8 4.6 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1cccc(Cl)c1Cl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
10079315 174647 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL 859 21 9 7 4.2 Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)Nc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
CHEMBL431065 174647 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL 859 21 9 7 4.2 Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)Nc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
13822924 108721 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Displacement of [125I]gastrin from guinea pig gastric glandsDisplacement of [125I]gastrin from guinea pig gastric glands
ChEMBL 427 4 1 6 4.2 O=C(NC1N=C(c2ccccc2F)c2ccccc2-n2cnnc21)OCc1ccccc1 10.1021/jm00396a028
CHEMBL301172 108721 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Displacement of [125I]gastrin from guinea pig gastric glandsDisplacement of [125I]gastrin from guinea pig gastric glands
ChEMBL 427 4 1 6 4.2 O=C(NC1N=C(c2ccccc2F)c2ccccc2-n2cnnc21)OCc1ccccc1 10.1021/jm00396a028
13605417 214347 4 None - 1 Mouse 5.5 pIC50 = 5.5 Binding
Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 458 14 2 3 5.2 CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1ccc(Cl)c(Cl)c1 10.1016/S0960-894X(00)80687-3
CHEMBL9485 214347 4 None - 1 Mouse 5.5 pIC50 = 5.5 Binding
Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 458 14 2 3 5.2 CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1ccc(Cl)c(Cl)c1 10.1016/S0960-894X(00)80687-3
10453004 32897 9 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 390 3 2 3 3.5 CN1C(=O)C(NC(=O)NC2CCCCC2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL135618 32897 9 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 390 3 2 3 3.5 CN1C(=O)C(NC(=O)NC2CCCCC2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
14991576 108991 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 866 21 9 9 3.4 COc1ccc2[nH]c(C(=O)NCCCC[C@H](NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc3ccccc3)C(N)=O)cc2c1 10.1021/jm00089a010
CHEMBL302911 108991 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 866 21 9 9 3.4 COc1ccc2[nH]c(C(=O)NCCCC[C@H](NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc3ccccc3)C(N)=O)cc2c1 10.1021/jm00089a010
14991535 113572 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 841 22 9 9 2.9 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCc1cccc(O)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL3144534 113572 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 841 22 9 9 2.9 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCc1cccc(O)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
90663978 113581 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 883 23 8 10 3.3 COc1ccc(/C=C\C(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c(OC)c1 10.1021/jm00089a010
CHEMBL3144542 113581 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 883 23 8 10 3.3 COc1ccc(/C=C\C(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c(OC)c1 10.1021/jm00089a010
14991582 208028 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 871 21 7 8 4.3 CN(C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCNC(=O)/C=C/c1ccc(Cl)cc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL60385 208028 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 871 21 7 8 4.3 CN(C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCNC(=O)/C=C/c1ccc(Cl)cc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
3960 9124 23 None - 1 Rat 5.5 pIC50 = 5.5 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 458 14 2 3 5.2 CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCCC 10.1021/jm00079a003
891 9124 23 None - 1 Rat 5.5 pIC50 = 5.5 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 458 14 2 3 5.2 CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCCC 10.1021/jm00079a003
CHEMBL24938 9124 23 None - 1 Rat 5.5 pIC50 = 5.5 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 458 14 2 3 5.2 CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCCC 10.1021/jm00079a003
71449051 85260 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 455 7 3 4 3.6 O=C(O)CC[C@H](NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)NN1CCC2(CCCC2)CC1 10.1021/jm00079a003
CHEMBL2111827 85260 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 455 7 3 4 3.6 O=C(O)CC[C@H](NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)NN1CCC2(CCCC2)CC1 10.1021/jm00079a003
44349077 124619 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 458 14 2 3 5.2 CCCCCN(CCCCC)C(=O)C(CCC(=O)O)NC(=O)c1cc(Cl)cc(Cl)c1 10.1021/jm00079a003
CHEMBL340263 124619 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 458 14 2 3 5.2 CCCCCN(CCCCC)C(=O)C(CCC(=O)O)NC(=O)c1cc(Cl)cc(Cl)c1 10.1021/jm00079a003
14208250 174829 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 403 3 1 3 3.9 CN1C(=O)C(NC(=O)c2ccccc2Cl)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
CHEMBL432334 174829 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 403 3 1 3 3.9 CN1C(=O)C(NC(=O)c2ccccc2Cl)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
9865694 210955 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 399 3 2 2 5.2 O=C1Nc2ccc(Cl)cc2C(c2ccccc2)=N[C@@H]1Cc1c[nH]c2ccccc12 10.1021/jm00120a002
CHEMBL70728 210955 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 399 3 2 2 5.2 O=C1Nc2ccc(Cl)cc2C(c2ccccc2)=N[C@@H]1Cc1c[nH]c2ccccc12 10.1021/jm00120a002
44366097 128746 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
In vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 692 17 7 7 2.7 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(=O)O)CC(=O)NC(Cc1ccccc1)C(N)=O 10.1021/jm00123a003
CHEMBL359141 128746 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
In vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 692 17 7 7 2.7 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(=O)O)CC(=O)NC(Cc1ccccc1)C(N)=O 10.1021/jm00123a003
15614750 126101 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 426 4 3 3 3.9 O=C(NCC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1cc2ccccc2[nH]1 10.1021/jm00163a069
CHEMBL344154 126101 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 426 4 3 3 3.9 O=C(NCC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1cc2ccccc2[nH]1 10.1021/jm00163a069
10509945 96159 0 None - 2 Human 5.5 pIC50 = 5.5 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 896 26 9 9 2.1 CCCC[C@H](NC(=O)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL2369816 96159 0 None - 2 Human 5.5 pIC50 = 5.5 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 896 26 9 9 2.1 CCCC[C@H](NC(=O)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
46235271 80423 2 None -2 2 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I-CCK] from human CCK2R V3.28T, S3.29T mutant expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-CCK] from human CCK2R V3.28T, S3.29T mutant expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 649 7 1 6 6.7 Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 10.1021/acs.jmedchem.5b01110
CHEMBL2017835 80423 2 None -2 2 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I-CCK] from human CCK2R V3.28T, S3.29T mutant expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-CCK] from human CCK2R V3.28T, S3.29T mutant expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 649 7 1 6 6.7 Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 10.1021/acs.jmedchem.5b01110
44349254 23605 0 None - 0 Rat 4.5 pIC50 = 4.5 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 354 10 3 3 2.6 CCCCCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 10.1021/jm00079a003
CHEMBL124751 23605 0 None - 0 Rat 4.5 pIC50 = 4.5 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 354 10 3 3 2.6 CCCCCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 10.1021/jm00079a003
155531277 178410 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1821 72 18 23 2.1 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4465747 178410 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1821 72 18 23 2.1 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
10056421 113404 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL 857 21 9 10 3.2 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccc([N+](=O)[O-])cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm960509y
CHEMBL3143025 113404 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL 857 21 9 10 3.2 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccc([N+](=O)[O-])cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm960509y
44333278 11527 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortexDisplacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortex
ChEMBL 464 5 2 6 2.6 CCCN1C(=O)C(NC(=O)Nc2cccc(OC)c2)N=C(N2CCN(C)CC2)c2ccccc21 10.1016/0960-894X(95)00530-0
CHEMBL103791 11527 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortexDisplacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortex
ChEMBL 464 5 2 6 2.6 CCCN1C(=O)C(NC(=O)Nc2cccc(OC)c2)N=C(N2CCN(C)CC2)c2ccccc21 10.1016/0960-894X(95)00530-0
443375 214385 45 None 2 5 Mouse 7.5 pIC50 = 7.5 Binding
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00105a062
CHEMBL9506 214385 45 None 2 5 Mouse 7.5 pIC50 = 7.5 Binding
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00105a062
443375 214385 45 None 2 5 Mouse 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80687-3
CHEMBL9506 214385 45 None 2 5 Mouse 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80687-3
14843046 106621 0 None - 0 Mouse 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 473 5 1 4 5.4 COc1ccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)cc1 10.1021/jm00108a040
CHEMBL285707 106621 0 None - 0 Mouse 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 473 5 1 4 5.4 COc1ccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)cc1 10.1021/jm00108a040
443375 214385 45 None 2 5 Mouse 7.5 pIC50 = 7.5 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00057a005
CHEMBL9506 214385 45 None 2 5 Mouse 7.5 pIC50 = 7.5 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00057a005
44329487 115290 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 544 6 3 3 5.7 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)C[C@H](c3cccc(F)c3)N(CC(=O)NC(C)(C)C)C2=O)c1 10.1016/S0960-894X(01)80832-5
CHEMBL319986 115290 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 544 6 3 3 5.7 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)C[C@H](c3cccc(F)c3)N(CC(=O)NC(C)(C)C)C2=O)c1 10.1016/S0960-894X(01)80832-5
132190 127115 18 None - 0 Mouse 7.5 pIC50 = 7.5 Binding
The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in mouse brain at a pH of 6.5The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in mouse brain at a pH of 6.5
ChEMBL 435 3 2 2 4.9 O=C1NN(C(=O)Nc2ccc(Br)cc2)C(c2ccccc2)C1c1ccccc1 10.1016/S0960-894X(00)80684-8
CHEMBL352949 127115 18 None - 0 Mouse 7.5 pIC50 = 7.5 Binding
The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in mouse brain at a pH of 6.5The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in mouse brain at a pH of 6.5
ChEMBL 435 3 2 2 4.9 O=C1NN(C(=O)Nc2ccc(Br)cc2)C(c2ccccc2)C1c1ccccc1 10.1016/S0960-894X(00)80684-8
11801335 126313 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Concentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cellsConcentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL 579 7 2 4 5.5 CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccc(F)cc1 10.1021/jm950626d
CHEMBL345786 126313 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Concentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cellsConcentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL 579 7 2 4 5.5 CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccc(F)cc1 10.1021/jm950626d
CHEMBL1172251 215362 0 None -2 4 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2010.05.078
10649606 56390 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]BDZ1 from CCK2R (unknown origin) expressed in CHO cellsDisplacement of [125I]BDZ1 from CCK2R (unknown origin) expressed in CHO cells
ChEMBL 519 6 3 4 4.5 O=C(CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)Nc1ccccc1 10.1016/j.bmcl.2015.03.051
CHEMBL156605 56390 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]BDZ1 from CCK2R (unknown origin) expressed in CHO cellsDisplacement of [125I]BDZ1 from CCK2R (unknown origin) expressed in CHO cells
ChEMBL 519 6 3 4 4.5 O=C(CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)Nc1ccccc1 10.1016/j.bmcl.2015.03.051
132916 9935 16 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesInhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranes
ChEMBL 438 3 2 3 3.8 O=C(c1cc2c([nH]1)cccc2)N[C@H]1N=C(c2ccccc2F)c2c3N(C1=O)CCc3ccc2 10.1016/S0960-894X(96)00609-9
874 9935 16 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesInhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranes
ChEMBL 438 3 2 3 3.8 O=C(c1cc2c([nH]1)cccc2)N[C@H]1N=C(c2ccccc2F)c2c3N(C1=O)CCc3ccc2 10.1016/S0960-894X(96)00609-9
CHEMBL300072 9935 16 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesInhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranes
ChEMBL 438 3 2 3 3.8 O=C(c1cc2c([nH]1)cccc2)N[C@H]1N=C(c2ccccc2F)c2c3N(C1=O)CCc3ccc2 10.1016/S0960-894X(96)00609-9
9977368 123026 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 385 3 2 4 3.0 CN1C(=O)C(NC(=O)Nc2cccnc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL335865 123026 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 385 3 2 4 3.0 CN1C(=O)C(NC(=O)Nc2cccnc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
44370451 57564 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 435 15 3 4 4.3 CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)O)NC(=O)Nc1cccc(OC)c1 10.1021/jm00164a020
CHEMBL157658 57564 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 435 15 3 4 4.3 CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)O)NC(=O)Nc1cccc(OC)c1 10.1021/jm00164a020
9896825 109754 0 None - 1 Mouse 6.5 pIC50 = 6.5 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 742 14 6 10 2.9 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCC(=O)NCCSCc4csc(N=C(N)N)n4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL30656 109754 0 None - 1 Mouse 6.5 pIC50 = 6.5 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 742 14 6 10 2.9 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCC(=O)NCCSCc4csc(N=C(N)N)n4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
19766170 65931 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 383 5 3 4 2.2 COc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)O)C2=O)c1 10.1016/S0960-894X(00)80683-6
CHEMBL169931 65931 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 383 5 3 4 2.2 COc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)O)C2=O)c1 10.1016/S0960-894X(00)80683-6
15689732 113392 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 870 21 9 10 3.0 COC(=O)c1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
CHEMBL3142906 113392 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 870 21 9 10 3.0 COC(=O)c1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
15689732 113392 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Displacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL 870 21 9 10 3.0 COC(=O)c1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm960509y
CHEMBL3142906 113392 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Displacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL 870 21 9 10 3.0 COC(=O)c1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm960509y
15104602 16224 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 486 13 3 2 6.2 CCCCCN(CCCCC)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1cc2ccccc2[nH]1 10.1021/jm00116a002
CHEMBL111808 16224 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 486 13 3 2 6.2 CCCCCN(CCCCC)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1cc2ccccc2[nH]1 10.1021/jm00116a002
44349024 23903 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 402 8 3 3 3.5 CC(C)(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1ccc(Cl)c(Cl)c1 10.1021/jm00079a003
CHEMBL125551 23903 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 402 8 3 3 3.5 CC(C)(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1ccc(Cl)c(Cl)c1 10.1021/jm00079a003
14208266 111157 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 371 3 3 4 2.9 O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccc(O)cc1 10.1021/jm00120a002
CHEMBL310250 111157 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 371 3 3 4 2.9 O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccc(O)cc1 10.1021/jm00120a002
44375212 172175 0 None - 0 Mouse 4.5 pIC50 = 4.5 Binding
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 554 10 6 7 4.0 O=C(O)c1cccc(N/C(S)=N\Nc2ccc(S(=O)(=O)NCCc3c[nH]c4ccccc34)cc2[N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
CHEMBL423803 172175 0 None - 0 Mouse 4.5 pIC50 = 4.5 Binding
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 554 10 6 7 4.0 O=C(O)c1cccc(N/C(S)=N\Nc2ccc(S(=O)(=O)NCCc3c[nH]c4ccccc34)cc2[N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
44359614 38642 0 None - 0 Mouse 6.5 pIC50 = 6.5 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 8 3 4 5.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)CNC1CCCCC1 10.1021/jm970065l
CHEMBL140701 38642 0 None - 0 Mouse 6.5 pIC50 = 6.5 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 8 3 4 5.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)CNC1CCCCC1 10.1021/jm970065l
10507561 127779 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Compound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transfected with cDNA of human Cholecystokinin type B receptorCompound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transfected with cDNA of human Cholecystokinin type B receptor
ChEMBL 585 7 2 4 5.4 CC(C)N(C(=O)CN1C(=O)C(NC(=O)c2cc3ccccc3[nH]2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/jm9601664
CHEMBL356408 127779 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Compound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transfected with cDNA of human Cholecystokinin type B receptorCompound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transfected with cDNA of human Cholecystokinin type B receptor
ChEMBL 585 7 2 4 5.4 CC(C)N(C(=O)CN1C(=O)C(NC(=O)c2cc3ccccc3[nH]2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/jm9601664
44365359 128066 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
Tested for 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecystokinin type B receptorTested for 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecystokinin type B receptor
ChEMBL 546 12 3 5 4.5 COc1ccc(N(C(=O)CN(C(=O)[C@@H](CCC(=O)O)NC(=O)Nc2ccccc2)c2ccccc2)C(C)C)cc1 10.1016/S0960-894X(97)00062-0
CHEMBL357983 128066 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
Tested for 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecystokinin type B receptorTested for 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecystokinin type B receptor
ChEMBL 546 12 3 5 4.5 COc1ccc(N(C(=O)CN(C(=O)[C@@H](CCC(=O)O)NC(=O)Nc2ccccc2)c2ccccc2)C(C)C)cc1 10.1016/S0960-894X(97)00062-0
15177358 105847 0 None - 0 Mouse 6.5 pIC50 = 6.5 Binding
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 515 9 4 4 4.6 O=C(NC(Cc1c[nH]c2ccccc12)NC(=O)C(CO)Cc1ccccc1)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
CHEMBL280502 105847 0 None - 0 Mouse 6.5 pIC50 = 6.5 Binding
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 515 9 4 4 4.6 O=C(NC(Cc1c[nH]c2ccccc12)NC(=O)C(CO)Cc1ccccc1)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
10789434 213415 0 None - 0 Mouse 6.5 pIC50 = 6.5 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 444 6 3 8 3.1 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccnc2)c1 10.1021/jm970373j
CHEMBL8921 213415 0 None - 0 Mouse 6.5 pIC50 = 6.5 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 444 6 3 8 3.1 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccnc2)c1 10.1021/jm970373j
10413618 209570 0 None - 1 Mouse 7.5 pIC50 = 7.5 Binding
Binding affinity towards Cholecystokinin type B receptor in mouse cortex membraneBinding affinity towards Cholecystokinin type B receptor in mouse cortex membrane
ChEMBL 499 8 3 3 5.4 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 10.1016/s0960-894x(00)00198-0
CHEMBL62205 209570 0 None - 1 Mouse 7.5 pIC50 = 7.5 Binding
Binding affinity towards Cholecystokinin type B receptor in mouse cortex membraneBinding affinity towards Cholecystokinin type B receptor in mouse cortex membrane
ChEMBL 499 8 3 3 5.4 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 10.1016/s0960-894x(00)00198-0
15667018 164561 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 998 27 10 11 2.5 CCCC[C@H](NC(=O)c1ccc2cc(OS(=O)(=O)O)ccc2c1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
CHEMBL408286 164561 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 998 27 10 11 2.5 CCCC[C@H](NC(=O)c1ccc2cc(OS(=O)(=O)O)ccc2c1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
9983419 116164 0 None - 0 Mouse 7.5 pIC50 = 7.5 Binding
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 499 8 3 3 5.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccc1 10.1021/jm00105a062
CHEMBL321946 116164 0 None - 0 Mouse 7.5 pIC50 = 7.5 Binding
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 499 8 3 3 5.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccc1 10.1021/jm00105a062
10030027 24718 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 532 5 3 3 5.6 Cc1ccc2c(c1)[C@@H](c1ccccc1)C[C@@H](NC(=O)Nc1cccc(Cl)c1)C(=O)N2CC(=O)NC(C)(C)C 10.1021/jm00048a015
CHEMBL126002 24718 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 532 5 3 3 5.6 Cc1ccc2c(c1)[C@@H](c1ccccc1)C[C@@H](NC(=O)Nc1cccc(Cl)c1)C(=O)N2CC(=O)NC(C)(C)C 10.1021/jm00048a015
73346731 88321 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranesInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranes
ChEMBL 1017 29 9 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCCc1ccccc1)CC(=O)O 10.1021/jm00072a024
CHEMBL216079 88321 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranesInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranes
ChEMBL 1017 29 9 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCCc1ccccc1)CC(=O)O 10.1021/jm00072a024
10413618 209570 0 None - 1 Mouse 7.5 pIC50 = 7.5 Binding
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 499 8 3 3 5.4 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 10.1016/S0960-894X(97)00356-9
CHEMBL62205 209570 0 None - 1 Mouse 7.5 pIC50 = 7.5 Binding
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 499 8 3 3 5.4 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 10.1016/S0960-894X(97)00356-9
10452597 33699 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 384 3 2 3 3.6 CN1C(=O)C(NC(=O)Nc2ccccc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL136408 33699 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 384 3 2 3 3.6 CN1C(=O)C(NC(=O)Nc2ccccc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
44280371 109805 0 None - 1 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 815 19 4 8 6.6 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCCCCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL30701 109805 0 None - 1 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 815 19 4 8 6.6 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCCCCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
10413618 209570 0 None - 1 Mouse 7.5 pIC50 = 7.5 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 499 8 3 3 5.4 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 10.1021/jm970065l
CHEMBL62205 209570 0 None - 1 Mouse 7.5 pIC50 = 7.5 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 499 8 3 3 5.4 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 10.1021/jm970065l
44356697 32394 1 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 456 5 2 5 3.4 COC(=O)Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
CHEMBL135166 32394 1 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 456 5 2 5 3.4 COC(=O)Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
44280399 109872 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 603 10 4 5 4.6 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(Cc1ccc(O)cc1)C(=O)O 10.1021/jm950372w
CHEMBL30756 109872 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 603 10 4 5 4.6 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(Cc1ccc(O)cc1)C(=O)O 10.1021/jm950372w
44280371 109805 0 None - 1 Mouse 6.5 pIC50 = 6.5 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 815 19 4 8 6.6 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCCCCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL30701 109805 0 None - 1 Mouse 6.5 pIC50 = 6.5 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 815 19 4 8 6.6 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCCCCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
15689739 113369 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 862 20 9 8 4.4 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccc2ccccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
CHEMBL3142683 113369 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 862 20 9 8 4.4 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccc2ccccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
15167816 211275 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 493 6 1 5 4.0 CCOC(=O)CN1C(=O)C(NC(=O)c2ccccc2Cl)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00078a018
CHEMBL72546 211275 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 493 6 1 5 4.0 CCOC(=O)CN1C(=O)C(NC(=O)c2ccccc2Cl)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00078a018
9821357 24051 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 382 9 3 3 3.2 CC(C)(C)CCCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 10.1021/jm00079a003
CHEMBL125703 24051 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 382 9 3 3 3.2 CC(C)(C)CCCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 10.1021/jm00079a003
10001488 171705 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 408 4 3 3 3.6 O=C(Cc1c[nH]c2ccccc12)NC1N=C(c2ccccc2)c2ccccc2NC1=O 10.1021/jm00120a002
CHEMBL422411 171705 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 408 4 3 3 3.6 O=C(Cc1c[nH]c2ccccc12)NC1N=C(c2ccccc2)c2ccccc2NC1=O 10.1021/jm00120a002
15200522 127246 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
Tested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pigTested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pig
ChEMBL 422 4 2 3 3.7 CN1C(=O)C(NC(=O)Cc2c[nH]c3ccccc23)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80682-4
CHEMBL354126 127246 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
Tested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pigTested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pig
ChEMBL 422 4 2 3 3.7 CN1C(=O)C(NC(=O)Cc2c[nH]c3ccccc23)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80682-4
10719200 176281 0 None - 0 Mouse 6.5 pIC50 = 6.5 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 471 6 3 3 5.7 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)Nc1ccccc1 10.1021/jm970065l
CHEMBL443284 176281 0 None - 0 Mouse 6.5 pIC50 = 6.5 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 471 6 3 3 5.7 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)Nc1ccccc1 10.1021/jm970065l
10528637 104079 0 None - 0 Mouse 7.5 pIC50 = 7.5 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 477 6 3 7 4.4 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(Cl)c2)c1 10.1021/jm970373j
CHEMBL269123 104079 0 None - 0 Mouse 7.5 pIC50 = 7.5 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 477 6 3 7 4.4 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(Cl)c2)c1 10.1021/jm970373j
10838356 214423 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Compound was evaluated for functional activity on Cholecystokinin type B receptor (CCK-B) receptor carried out on guinea pig stomach cells.Compound was evaluated for functional activity on Cholecystokinin type B receptor (CCK-B) receptor carried out on guinea pig stomach cells.
ChEMBL 477 6 3 7 4.4 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2ccc(Cl)cc2)c1 10.1021/jm970373j
CHEMBL9524 214423 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Compound was evaluated for functional activity on Cholecystokinin type B receptor (CCK-B) receptor carried out on guinea pig stomach cells.Compound was evaluated for functional activity on Cholecystokinin type B receptor (CCK-B) receptor carried out on guinea pig stomach cells.
ChEMBL 477 6 3 7 4.4 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2ccc(Cl)cc2)c1 10.1021/jm970373j
14843052 106502 0 None - 0 Mouse 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 486 5 1 4 5.5 CN(C)c1ccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)cc1 10.1021/jm00108a040
CHEMBL284853 106502 0 None - 0 Mouse 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 486 5 1 4 5.5 CN(C)c1ccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)cc1 10.1021/jm00108a040
9978270 85587 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 399 3 3 4 3.2 CN1C(=O)[C@H](NC(=O)Nc2cccc(N)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL2112749 85587 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 399 3 3 4 3.2 CN1C(=O)[C@H](NC(=O)Nc2cccc(N)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
10323690 107274 0 None - 2 Mouse 6.5 pIC50 = 6.5 Binding
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 499 8 3 3 5.4 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccc1 10.1021/jm00105a062
CHEMBL2114401 107274 0 None - 2 Mouse 6.5 pIC50 = 6.5 Binding
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 499 8 3 3 5.4 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccc1 10.1021/jm00105a062
CHEMBL291033 107274 0 None - 2 Mouse 6.5 pIC50 = 6.5 Binding
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 499 8 3 3 5.4 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccc1 10.1021/jm00105a062
44382698 66246 0 None - 0 Mouse 6.5 pIC50 = 6.5 Binding
Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 742 15 5 7 5.3 O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccc(OS(=O)(=O)O)cc1)NCCc1ccccc1 10.1016/S0960-894X(00)80687-3
CHEMBL171375 66246 0 None - 0 Mouse 6.5 pIC50 = 6.5 Binding
Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 742 15 5 7 5.3 O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccc(OS(=O)(=O)O)cc1)NCCc1ccccc1 10.1016/S0960-894X(00)80687-3
14843041 131820 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of [125I]-labeled CCK-8 sulfate binding to Cholecystokinin type B receptor in guinea pig brain membranesInhibition of [125I]-labeled CCK-8 sulfate binding to Cholecystokinin type B receptor in guinea pig brain membranes
ChEMBL 471 5 1 3 6.0 CCc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
CHEMBL36436 131820 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of [125I]-labeled CCK-8 sulfate binding to Cholecystokinin type B receptor in guinea pig brain membranesInhibition of [125I]-labeled CCK-8 sulfate binding to Cholecystokinin type B receptor in guinea pig brain membranes
ChEMBL 471 5 1 3 6.0 CCc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
44280029 103216 0 None - 1 Mouse 6.5 pIC50 = 6.5 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 740 15 6 9 3.5 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCC(=O)NCCSCc3csc(N=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
CHEMBL262125 103216 0 None - 1 Mouse 6.5 pIC50 = 6.5 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 740 15 6 9 3.5 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCC(=O)NCCSCc3csc(N=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
CHEMBL3142687 217909 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL None None None CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)NCc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
44381758 18502 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Displacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortexDisplacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortex
ChEMBL 565 9 2 5 3.4 CN1CCN(CCNC(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCC3)CC2)CC1 10.1016/S0960-894X(00)80681-2
CHEMBL1181391 18502 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Displacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortexDisplacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortex
ChEMBL 565 9 2 5 3.4 CN1CCN(CCNC(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCC3)CC2)CC1 10.1016/S0960-894X(00)80681-2
CHEMBL169440 18502 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Displacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortexDisplacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortex
ChEMBL 565 9 2 5 3.4 CN1CCN(CCNC(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCC3)CC2)CC1 10.1016/S0960-894X(00)80681-2
15104611 116034 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 514 13 3 4 6.0 CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cc(O)c2ccccc2n1 10.1021/jm00116a002
CHEMBL321811 116034 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 514 13 3 4 6.0 CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cc(O)c2ccccc2n1 10.1021/jm00116a002
14208313 74514 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 437 3 1 3 4.3 CN1C(=O)[C@H](NC(=O)c2ccc(C(F)(F)F)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL1907842 74514 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 437 3 1 3 4.3 CN1C(=O)[C@H](NC(=O)c2ccc(C(F)(F)F)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
44349391 123828 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 422 9 3 3 4.2 CCC1(CC)CCC(NC(=O)C(CCC(=O)O)NC(=O)c2cccc(Cl)c2)CC1 10.1021/jm00079a003
CHEMBL339115 123828 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 422 9 3 3 4.2 CCC1(CC)CCC(NC(=O)C(CCC(=O)O)NC(=O)c2cccc(Cl)c2)CC1 10.1021/jm00079a003
44280112 106371 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 684 11 3 5 5.4 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCCc2ccccc21 10.1021/jm950372w
CHEMBL283924 106371 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 684 11 3 5 5.4 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCCc2ccccc21 10.1021/jm950372w
10091467 123483 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 385 3 2 4 3.0 CN1C(=O)C(NC(=O)Nc2ccccn2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL337285 123483 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 385 3 2 4 3.0 CN1C(=O)C(NC(=O)Nc2ccccn2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
14802539 83327 1 None - 1 Mouse 7.5 pIC50 = 7.5 Binding
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 614 12 5 5 4.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1 10.1016/S0960-894X(01)80769-1
CHEMBL2062144 83327 1 None - 1 Mouse 7.5 pIC50 = 7.5 Binding
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 614 12 5 5 4.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1 10.1016/S0960-894X(01)80769-1
14843038 144986 0 None - 0 Mouse 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 473 5 1 4 5.4 COc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
CHEMBL37699 144986 0 None - 0 Mouse 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 473 5 1 4 5.4 COc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
10369442 115324 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 521 7 3 5 3.6 Cc1cccc(NC(=O)N[C@H](COC(=O)N2CCCC2)C(=O)N2CCC(C(=O)Nc3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
CHEMBL320154 115324 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 521 7 3 5 3.6 Cc1cccc(NC(=O)N[C@H](COC(=O)N2CCCC2)C(=O)N2CCC(C(=O)Nc3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
44332067 11164 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL 546 13 3 4 3.5 CCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N(CCc1ccccc1)CC(=O)N1CCC[C@H]1C(=O)O 10.1016/S0960-894X(96)00546-X
CHEMBL101352 11164 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL 546 13 3 4 3.5 CCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N(CCc1ccccc1)CC(=O)N1CCC[C@H]1C(=O)O 10.1016/S0960-894X(96)00546-X
CHEMBL100609 215231 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL None None None COc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
CHEMBL100609 215231 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Displacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL None None None COc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm960509y
44280114 11882 0 None - 2 Human 5.5 pIC50 = 5.5 Binding
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 567 7 2 4 6.1 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1CCC(C(=O)c2ccccc2)CC1 10.1016/0960-894X(95)00537-3
CHEMBL105618 11882 0 None - 2 Human 5.5 pIC50 = 5.5 Binding
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 567 7 2 4 6.1 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1CCC(C(=O)c2ccccc2)CC1 10.1016/0960-894X(95)00537-3
15167800 39493 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 412 4 3 3 4.4 O=C(NCC1CNc2ccccc2C(c2ccccc2F)=N1)c1cc2ccccc2[nH]1 10.1021/jm00163a069
CHEMBL141365 39493 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 412 4 3 3 4.4 O=C(NCC1CNc2ccccc2C(c2ccccc2F)=N1)c1cc2ccccc2[nH]1 10.1021/jm00163a069
44209151 66208 1 None - 0 Human 4.5 pIC50 = 4.5 Binding
Tested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brainTested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL 301 3 2 2 3.8 O=C(Cc1ccccc1)Nc1cc2c3ccccc3nc-2c[nH]1 10.1016/S0960-894X(00)80682-4
CHEMBL171108 66208 1 None - 0 Human 4.5 pIC50 = 4.5 Binding
Tested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brainTested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL 301 3 2 2 3.8 O=C(Cc1ccccc1)Nc1cc2c3ccccc3nc-2c[nH]1 10.1016/S0960-894X(00)80682-4
44303237 107584 0 None - 0 Mouse 6.5 pIC50 = 6.5 Binding
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 590 10 4 8 4.3 CC(Cc1ccc(-c2csnn2)cc1)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CO)[C@H](O)c1ccccc1 10.1016/S0960-894X(97)00356-9
CHEMBL293178 107584 0 None - 0 Mouse 6.5 pIC50 = 6.5 Binding
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 590 10 4 8 4.3 CC(Cc1ccc(-c2csnn2)cc1)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CO)[C@H](O)c1ccccc1 10.1016/S0960-894X(97)00356-9
44280177 106265 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 601 11 3 4 5.3 O=C(O)C[C@H](Cc1ccccc1)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL283204 106265 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 601 11 3 4 5.3 O=C(O)C[C@H](Cc1ccccc1)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
10604135 85614 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Binding affinity by competitive inhibition of the radioligand [3H]pCCK-8 at Cholecystokinin type B receptor from rat cerebral cortex membraneBinding affinity by competitive inhibition of the radioligand [3H]pCCK-8 at Cholecystokinin type B receptor from rat cerebral cortex membrane
ChEMBL 637 8 3 5 5.1 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@H]12)OC1C2CC3CC(C2)CC1C3 10.1021/jm991078x
CHEMBL2112823 85614 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Binding affinity by competitive inhibition of the radioligand [3H]pCCK-8 at Cholecystokinin type B receptor from rat cerebral cortex membraneBinding affinity by competitive inhibition of the radioligand [3H]pCCK-8 at Cholecystokinin type B receptor from rat cerebral cortex membrane
ChEMBL 637 8 3 5 5.1 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@H]12)OC1C2CC3CC(C2)CC1C3 10.1021/jm991078x
44396765 74149 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Inhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenatesInhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenates
ChEMBL 594 8 2 5 5.4 O=C(OC1C2CC3CC(C2)CC1C3)[C@H](Cc1c[nH]c2ccccc12)N[C@@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)CC12 10.1021/jm0498755
CHEMBL188667 74149 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Inhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenatesInhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenates
ChEMBL 594 8 2 5 5.4 O=C(OC1C2CC3CC(C2)CC1C3)[C@H](Cc1c[nH]c2ccccc12)N[C@@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)CC12 10.1021/jm0498755
44327735 114056 0 None - 0 Mouse 6.5 pIC50 = 6.5 Binding
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 627 15 3 4 7.1 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCCCCCC(=O)O)CCc1ccccc1 10.1016/S0960-894X(01)80769-1
CHEMBL317062 114056 0 None - 0 Mouse 6.5 pIC50 = 6.5 Binding
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 627 15 3 4 7.1 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCCCCCC(=O)O)CCc1ccccc1 10.1016/S0960-894X(01)80769-1
10413579 123861 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 498 5 3 3 5.0 Cc1ccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)c3ccccc3N(CC(=O)NC(C)(C)C)C2=O)cc1 10.1021/jm00048a015
CHEMBL339260 123861 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 498 5 3 3 5.0 Cc1ccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)c3ccccc3N(CC(=O)NC(C)(C)C)C2=O)cc1 10.1021/jm00048a015
10047172 85590 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 410 4 2 3 4.3 C=Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
CHEMBL2112752 85590 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 410 4 2 3 4.3 C=Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
44280252 106629 0 None - 0 Mouse 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 655 11 5 8 3.7 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCSCc3csc(N=C(N)N)n3)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL285746 106629 0 None - 0 Mouse 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 655 11 5 8 3.7 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCSCc3csc(N=C(N)N)n3)C2=O)c1 10.1016/S0960-894X(96)00248-X
44331993 164988 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL 609 5 1 5 5.5 CC(C)(C)OC(=O)N1c2ccccc2C[C@@H]1C(=O)N1[C@H](c2ccccc2)CC[C@@H]1C(=O)N1Cc2ccccc2C[C@@H]1CC(=O)O 10.1016/S0960-894X(96)00546-X
CHEMBL408803 164988 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL 609 5 1 5 5.5 CC(C)(C)OC(=O)N1c2ccccc2C[C@@H]1C(=O)N1[C@H](c2ccccc2)CC[C@@H]1C(=O)N1Cc2ccccc2C[C@@H]1CC(=O)O 10.1016/S0960-894X(96)00546-X
10369806 123598 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 532 5 3 3 5.6 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@@H](NC(=O)Nc1cccc(Cl)c1)C[C@H]2c1ccccc1 10.1021/jm00048a015
CHEMBL337937 123598 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 532 5 3 3 5.6 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@@H](NC(=O)Nc1cccc(Cl)c1)C[C@H]2c1ccccc1 10.1021/jm00048a015
44272229 105521 0 None - 1 Mouse 6.5 pIC50 = 6.5 Binding
Concentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranesConcentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranes
ChEMBL 635 15 6 6 3.5 CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 10.1016/S0960-894X(00)80644-7
CHEMBL278032 105521 0 None - 1 Mouse 6.5 pIC50 = 6.5 Binding
Concentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranesConcentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranes
ChEMBL 635 15 6 6 3.5 CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 10.1016/S0960-894X(00)80644-7
44272229 105521 0 None - 1 Mouse 6.5 pIC50 = 6.5 Binding
Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)
ChEMBL 635 15 6 6 3.5 CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 10.1016/S0960-894X(01)80253-5
CHEMBL278032 105521 0 None - 1 Mouse 6.5 pIC50 = 6.5 Binding
Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)
ChEMBL 635 15 6 6 3.5 CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 10.1016/S0960-894X(01)80253-5
44280213 108395 0 None - 1 Mouse 6.5 pIC50 = 6.5 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 685 12 5 9 3.7 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCSCc4csc(N=C(N)N)n4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL29888 108395 0 None - 1 Mouse 6.5 pIC50 = 6.5 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 685 12 5 9 3.7 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCSCc4csc(N=C(N)N)n4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL318570 217994 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL None None None Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
44209154 65868 1 None - 0 Human 4.5 pIC50 = 4.5 Binding
Tested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pigTested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pig
ChEMBL 315 4 2 2 4.2 O=C(CCc1ccccc1)Nc1cc2c3ccccc3nc-2c[nH]1 10.1016/S0960-894X(00)80682-4
CHEMBL169675 65868 1 None - 0 Human 4.5 pIC50 = 4.5 Binding
Tested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pigTested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pig
ChEMBL 315 4 2 2 4.2 O=C(CCc1ccccc1)Nc1cc2c3ccccc3nc-2c[nH]1 10.1016/S0960-894X(00)80682-4
44283030 106431 0 None - 0 Mouse 6.5 pIC50 = 6.5 Binding
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 629 12 3 7 5.4 COC(=O)CCC(=O)N[C@H](COC(=O)C(C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)c1ccccc1 10.1021/jm00086a017
CHEMBL284361 106431 0 None - 0 Mouse 6.5 pIC50 = 6.5 Binding
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 629 12 3 7 5.4 COC(=O)CCC(=O)N[C@H](COC(=O)C(C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)c1ccccc1 10.1021/jm00086a017
44280091 175217 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 640 10 3 4 5.7 CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm950372w
CHEMBL434967 175217 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 640 10 3 4 5.7 CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm950372w
44385777 135589 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.
ChEMBL 573 8 4 5 3.2 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)[C@](Cc3ccccc3)(C(N)=O)C[C@H]12 10.1016/0960-894X(96)00160-6
CHEMBL366943 135589 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.
ChEMBL 573 8 4 5 3.2 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)[C@](Cc3ccccc3)(C(N)=O)C[C@H]12 10.1016/0960-894X(96)00160-6
44283177 107080 0 None - 0 Mouse 5.5 pIC50 = 5.5 Binding
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 655 16 2 5 7.6 CCOC(=O)CCCCCC(=O)N(CCc1ccccc1)CC(C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
CHEMBL289239 107080 0 None - 0 Mouse 5.5 pIC50 = 5.5 Binding
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 655 16 2 5 7.6 CCOC(=O)CCCCCC(=O)N(CCc1ccccc1)CC(C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
44349262 123730 0 None - 0 Rat 4.5 pIC50 = 4.5 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 354 9 3 3 2.5 CC(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 10.1021/jm00079a003
CHEMBL338607 123730 0 None - 0 Rat 4.5 pIC50 = 4.5 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 354 9 3 3 2.5 CC(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 10.1021/jm00079a003
44279957 105987 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 553 10 3 4 4.7 CC(C)CC(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O 10.1021/jm950372w
CHEMBL281507 105987 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 553 10 3 4 4.7 CC(C)CC(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O 10.1021/jm950372w
10598999 214442 0 None - 0 Mouse 5.5 pIC50 = 5.5 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 435 4 3 5 5.0 Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc3ccccc23)c1 10.1021/jm970373j
CHEMBL9532 214442 0 None - 0 Mouse 5.5 pIC50 = 5.5 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 435 4 3 5 5.0 Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc3ccccc23)c1 10.1021/jm970373j
44368567 175514 0 None - 0 Mouse 7.4 pIC50 = 7.4 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 495 9 4 4 4.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1CCCCC1F)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
CHEMBL437039 175514 0 None - 0 Mouse 7.4 pIC50 = 7.4 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 495 9 4 4 4.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1CCCCC1F)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
10765241 110757 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 433 5 3 4 3.8 CCCN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C([C@H]2CCCCN2)c2ccccc21 10.1021/jm9608523
CHEMBL309299 110757 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 433 5 3 4 3.8 CCCN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C([C@H]2CCCCN2)c2ccccc21 10.1021/jm9608523
44329352 118214 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 544 6 3 3 5.7 Cc1ccccc1[C@H]1C[C@@H](NC(=O)Nc2cccc(F)c2)C(=O)N(CC(=O)NC(C)(C)C)[C@@H](c2ccccc2)C1 10.1016/S0960-894X(01)80832-5
CHEMBL327496 118214 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 544 6 3 3 5.7 Cc1ccccc1[C@H]1C[C@@H](NC(=O)Nc2cccc(F)c2)C(=O)N(CC(=O)NC(C)(C)C)[C@@H](c2ccccc2)C1 10.1016/S0960-894X(01)80832-5
44280741 163341 0 None - 1 Human 7.4 pIC50 = 7.4 Binding
Inhibitory activity against gastrin receptor.Inhibitory activity against gastrin receptor.
ChEMBL 759 15 4 8 5.8 CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
CHEMBL406844 163341 0 None - 1 Human 7.4 pIC50 = 7.4 Binding
Inhibitory activity against gastrin receptor.Inhibitory activity against gastrin receptor.
ChEMBL 759 15 4 8 5.8 CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
CHEMBL316925 217975 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL None None None CC(C)(C)OC(=O)N1c2ccccc2C[C@@H]1C(=O)N1[C@H](c2ccccc2)CC[C@@H]1C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1CCC[C@@H]1C(=O)O 10.1016/S0960-894X(96)00546-X
44327457 114115 0 None - 0 Mouse 7.4 pIC50 = 7.4 Binding
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 571 11 3 4 5.6 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCC(=O)O)CCc1ccccc1 10.1016/S0960-894X(01)80769-1
CHEMBL317577 114115 0 None - 0 Mouse 7.4 pIC50 = 7.4 Binding
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 571 11 3 4 5.6 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCC(=O)O)CCc1ccccc1 10.1016/S0960-894X(01)80769-1
14843038 144986 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of [125I]-labeled CCK-8 sulfate binding to Cholecystokinin type B receptor in guinea pig brain membranesInhibition of [125I]-labeled CCK-8 sulfate binding to Cholecystokinin type B receptor in guinea pig brain membranes
ChEMBL 473 5 1 4 5.4 COc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
CHEMBL37699 144986 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of [125I]-labeled CCK-8 sulfate binding to Cholecystokinin type B receptor in guinea pig brain membranesInhibition of [125I]-labeled CCK-8 sulfate binding to Cholecystokinin type B receptor in guinea pig brain membranes
ChEMBL 473 5 1 4 5.4 COc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
10462874 105612 0 None - 0 Mouse 5.4 pIC50 = 5.4 Binding
Binding affinity towards Cholecystokinin type B receptor in mouse cortex membraneBinding affinity towards Cholecystokinin type B receptor in mouse cortex membrane
ChEMBL 766 16 6 5 7.1 O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1)NCCCCNC(=O)Nc1ccccc1Cl 10.1016/s0960-894x(00)00198-0
CHEMBL278780 105612 0 None - 0 Mouse 5.4 pIC50 = 5.4 Binding
Binding affinity towards Cholecystokinin type B receptor in mouse cortex membraneBinding affinity towards Cholecystokinin type B receptor in mouse cortex membrane
ChEMBL 766 16 6 5 7.1 O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1)NCCCCNC(=O)Nc1ccccc1Cl 10.1016/s0960-894x(00)00198-0
44381829 175307 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptorDisplacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptor
ChEMBL 840 23 10 10 2.9 CC(C)(C)OC(=O)N[C@H](CNN[C@@H](CCCCNC(=O)/C=C/c1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)Cc1c[nH]c2ccccc12 10.1016/S0960-894X(00)80680-0
CHEMBL435465 175307 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptorDisplacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptor
ChEMBL 840 23 10 10 2.9 CC(C)(C)OC(=O)N[C@H](CNN[C@@H](CCCCNC(=O)/C=C/c1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)Cc1c[nH]c2ccccc12 10.1016/S0960-894X(00)80680-0
44375062 62456 0 None - 0 Mouse 5.4 pIC50 = 5.4 Binding
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 554 10 6 7 4.0 O=C(O)c1cccc(NS(=O)(=O)c2ccc(N/N=C(/S)NCCc3c[nH]c4ccccc34)c([N+](=O)[O-])c2)c1 10.1016/s0960-894x(01)00044-0
CHEMBL162184 62456 0 None - 0 Mouse 5.4 pIC50 = 5.4 Binding
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 554 10 6 7 4.0 O=C(O)c1cccc(NS(=O)(=O)c2ccc(N/N=C(/S)NCCc3c[nH]c4ccccc34)c([N+](=O)[O-])c2)c1 10.1016/s0960-894x(01)00044-0
44348835 23593 0 None - 0 Bovine 5.4 pIC50 = 5.4 Binding
Inhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatumInhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatum
ChEMBL 938 25 11 11 0.2 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00099a005
CHEMBL124719 23593 0 None - 0 Bovine 5.4 pIC50 = 5.4 Binding
Inhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatumInhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatum
ChEMBL 938 25 11 11 0.2 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00099a005
14991581 109214 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 855 22 8 9 3.2 CN(C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCNC(=O)CCc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL303994 109214 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 855 22 8 9 3.2 CN(C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCNC(=O)CCc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
44349314 23339 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 402 8 3 3 3.5 CC(C)(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1cc(Cl)cc(Cl)c1 10.1021/jm00079a003
CHEMBL123852 23339 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 402 8 3 3 3.5 CC(C)(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1cc(Cl)cc(Cl)c1 10.1021/jm00079a003
44280266 105553 0 None - 1 Mouse 5.4 pIC50 = 5.4 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 729 14 4 7 5.0 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL278217 105553 0 None - 1 Mouse 5.4 pIC50 = 5.4 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 729 14 4 7 5.0 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 10.1016/S0960-894X(96)00248-X
14208260 108896 0 None - 0 Human 4.4 pIC50 = 4.4 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 423 3 2 3 4.3 O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccc(C(F)(F)F)cc1 10.1021/jm00120a002
CHEMBL302359 108896 0 None - 0 Human 4.4 pIC50 = 4.4 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 423 3 2 3 4.3 O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccc(C(F)(F)F)cc1 10.1021/jm00120a002
44283086 126112 0 None - 0 Mouse 5.4 pIC50 = 5.4 Binding
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 482 8 2 2 7.2 CC(/C=C/CCc1ccccc1)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
CHEMBL34422 126112 0 None - 0 Mouse 5.4 pIC50 = 5.4 Binding
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 482 8 2 2 7.2 CC(/C=C/CCc1ccccc1)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
44349152 25334 0 None - 0 Rat 4.4 pIC50 = 4.4 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 354 10 3 3 2.6 CCCCCNC(=O)C(CCC(=O)O)NC(=O)c1ccc(Cl)cc1 10.1021/jm00079a003
CHEMBL127604 25334 0 None - 0 Rat 4.4 pIC50 = 4.4 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 354 10 3 3 2.6 CCCCCNC(=O)C(CCC(=O)O)NC(=O)c1ccc(Cl)cc1 10.1021/jm00079a003
10675328 118282 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 617 9 1 6 5.7 COc1ccc(N(C(=O)CN2C(=O)C(Cc3n[nH]c4ccccc34)(OC)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm970265x
CHEMBL327815 118282 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 617 9 1 6 5.7 COc1ccc(N(C(=O)CN2C(=O)C(Cc3n[nH]c4ccccc34)(OC)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm970265x
44283031 106765 0 None - 0 Mouse 5.4 pIC50 = 5.4 Binding
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 613 13 2 5 6.4 CCOC(=O)CCC(=O)N(CCc1ccccc1)CC(C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
CHEMBL286664 106765 0 None - 0 Mouse 5.4 pIC50 = 5.4 Binding
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 613 13 2 5 6.4 CCOC(=O)CCC(=O)N(CCc1ccccc1)CC(C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
CHEMBL414345 219903 7 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of 125I]-BH-(Thr,Nle)-CCK-9 binding to human CCK2 receptor expressed in COS-7 cellsInhibition of 125I]-BH-(Thr,Nle)-CCK-9 binding to human CCK2 receptor expressed in COS-7 cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCN=C(N)N)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm0498755
19766167 66009 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 420 4 2 3 3.1 Cc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 10.1016/S0960-894X(00)80683-6
CHEMBL170293 66009 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 420 4 2 3 3.1 Cc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 10.1016/S0960-894X(00)80683-6
14843051 106659 0 None - 0 Mouse 7.4 pIC50 = 7.4 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 489 5 1 4 6.1 CSc1ccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)cc1 10.1021/jm00108a040
CHEMBL285940 106659 0 None - 0 Mouse 7.4 pIC50 = 7.4 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 489 5 1 4 6.1 CSc1ccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)cc1 10.1021/jm00108a040
14843050 169922 0 None - 0 Mouse 7.4 pIC50 = 7.4 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 485 5 1 3 6.5 CC(C)c1ccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)cc1 10.1021/jm00108a040
CHEMBL417876 169922 0 None - 0 Mouse 7.4 pIC50 = 7.4 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 485 5 1 3 6.5 CC(C)c1ccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)cc1 10.1021/jm00108a040
CHEMBL285995 106668 0 None - 1 Human 7.4 pIC50 = 7.4 Binding
Inhibitory activity against gastrin receptor.Inhibitory activity against gastrin receptor.
ChEMBL 741 16 6 11 4.5 CN1C(=O)[C@H](NC(=O)Nc2cccc(CCOC(=O)NCCCNCCSCc3csc(C=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
11802426 107059 0 None 50 2 Rat 7.4 pIC50 = 7.4 Binding
Inhibitory activity against CCK-B receptorInhibitory activity against CCK-B receptor
ChEMBL 653 8 3 5 6.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1C[C@H](Oc2ccc(Cl)cc2Cl)C[C@@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
CHEMBL289021 107059 0 None 50 2 Rat 7.4 pIC50 = 7.4 Binding
Inhibitory activity against CCK-B receptorInhibitory activity against CCK-B receptor
ChEMBL 653 8 3 5 6.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1C[C@H](Oc2ccc(Cl)cc2Cl)C[C@@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
90663141 113381 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL 618 14 6 6 0.6 CC(C)C[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N1CC(=O)N[C@H](Cc2c[nH]c3ccccc23)C1=O 10.1016/S0960-894X(96)00546-X
CHEMBL3142755 113381 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL 618 14 6 6 0.6 CC(C)C[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N1CC(=O)N[C@H](Cc2c[nH]c3ccccc23)C1=O 10.1016/S0960-894X(96)00546-X
6956374 9184 5 None - 1 Mouse 6.4 pIC50 = 6.4 Binding
Half maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortexHalf maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 435 3 2 2 4.9 Brc1ccc(cc1)NC(=O)N1NC(=O)[C@@H]([C@H]1c1ccccc1)c1ccccc1 10.1021/jm000937a
902 9184 5 None - 1 Mouse 6.4 pIC50 = 6.4 Binding
Half maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortexHalf maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 435 3 2 2 4.9 Brc1ccc(cc1)NC(=O)N1NC(=O)[C@@H]([C@H]1c1ccccc1)c1ccccc1 10.1021/jm000937a
CHEMBL117281 9184 5 None - 1 Mouse 6.4 pIC50 = 6.4 Binding
Half maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortexHalf maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 435 3 2 2 4.9 Brc1ccc(cc1)NC(=O)N1NC(=O)[C@@H]([C@H]1c1ccccc1)c1ccccc1 10.1021/jm000937a
14843029 146012 0 None - 0 Mouse 6.4 pIC50 = 6.4 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 443 4 1 3 5.4 O=c1c2ccccc2nc(CCc2c[nH]c3ccccc23)n1-c1cccc(Br)c1 10.1021/jm00108a040
CHEMBL37887 146012 0 None - 0 Mouse 6.4 pIC50 = 6.4 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 443 4 1 3 5.4 O=c1c2ccccc2nc(CCc2c[nH]c3ccccc23)n1-c1cccc(Br)c1 10.1021/jm00108a040
44279808 105917 0 None - 1 Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 712 13 6 9 2.9 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCC(=O)NCCSCc3csc(N=C(N)N)n3)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL281082 105917 0 None - 1 Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 712 13 6 9 2.9 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCC(=O)NCCSCc3csc(N=C(N)N)n3)C2=O)c1 10.1016/S0960-894X(96)00248-X
44332281 11510 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL 455 12 3 3 4.3 CCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N(CCC1CCCCC1)CC(=O)O 10.1016/S0960-894X(96)00546-X
CHEMBL103713 11510 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL 455 12 3 3 4.3 CCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N(CCC1CCCCC1)CC(=O)O 10.1016/S0960-894X(96)00546-X
6956374 9184 5 None - 1 Mouse 6.4 pIC50 = 6.4 Binding
The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in mouse brain at a pH of 6.5The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in mouse brain at a pH of 6.5
ChEMBL 435 3 2 2 4.9 Brc1ccc(cc1)NC(=O)N1NC(=O)[C@@H]([C@H]1c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80684-8
902 9184 5 None - 1 Mouse 6.4 pIC50 = 6.4 Binding
The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in mouse brain at a pH of 6.5The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in mouse brain at a pH of 6.5
ChEMBL 435 3 2 2 4.9 Brc1ccc(cc1)NC(=O)N1NC(=O)[C@@H]([C@H]1c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80684-8
CHEMBL117281 9184 5 None - 1 Mouse 6.4 pIC50 = 6.4 Binding
The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in mouse brain at a pH of 6.5The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in mouse brain at a pH of 6.5
ChEMBL 435 3 2 2 4.9 Brc1ccc(cc1)NC(=O)N1NC(=O)[C@@H]([C@H]1c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80684-8
15689737 113376 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 862 20 9 8 4.5 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC/N=C(\S)Nc1ccc(Cl)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
CHEMBL3142701 113376 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 862 20 9 8 4.5 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC/N=C(\S)Nc1ccc(Cl)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
14208194 170215 2 None - 2 Mouse 5.4 pIC50 = 5.4 Binding
Half maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortexHalf maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm000937a
CHEMBL419764 170215 2 None - 2 Mouse 5.4 pIC50 = 5.4 Binding
Half maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortexHalf maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm000937a
14208317 74464 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 421 3 1 3 4.0 CN1C(=O)[C@H](NC(=O)c2ccccc2Cl)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL1907667 74464 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 421 3 1 3 4.0 CN1C(=O)[C@H](NC(=O)c2ccccc2Cl)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
14208194 170215 2 None - 2 Human 5.4 pIC50 = 5.4 Binding
The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain at a pH of 6.5The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain at a pH of 6.5
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80684-8
CHEMBL419764 170215 2 None - 2 Human 5.4 pIC50 = 5.4 Binding
The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain at a pH of 6.5The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain at a pH of 6.5
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80684-8
CHEMBL354363 218510 0 None - 0 Mouse 4.4 pIC50 = 4.4 Binding
Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N1CC(=O)N[C@@H](Cc2ccccc2)C1 10.1016/S0960-894X(01)80253-5
155524770 177717 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1641 66 14 19 4.5 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)NC(=O)Cc1ccc(O)cc1)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4455361 177717 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1641 66 14 19 4.5 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)NC(=O)Cc1ccc(O)cc1)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
44342477 117300 0 None - 1 Rat 5.4 pIC50 = 5.4 Binding
Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.
ChEMBL 588 8 3 6 3.9 COC(=O)[C@]1(Cc2ccccc2)C[C@@H]2[C@@H](NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)OC(C)(C)C)CCCN2C1=O 10.1016/0960-894X(96)00160-6
CHEMBL325070 117300 0 None - 1 Rat 5.4 pIC50 = 5.4 Binding
Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.
ChEMBL 588 8 3 6 3.9 COC(=O)[C@]1(Cc2ccccc2)C[C@@H]2[C@@H](NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)OC(C)(C)C)CCCN2C1=O 10.1016/0960-894X(96)00160-6
CHEMBL160753 215588 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
In vitro ability to inhibit [125I]Bolton-Hunter-CCK-8 binding to Cholecystokinin type B receptor in guinea pig cortexIn vitro ability to inhibit [125I]Bolton-Hunter-CCK-8 binding to Cholecystokinin type B receptor in guinea pig cortex
ChEMBL None None None CN[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00031a013
10745561 24607 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
In vitro inhibition of [3H]propionyl-CCK-8 binding to rat cerebral cortex membranes at Cholecystokinin type B receptor.In vitro inhibition of [3H]propionyl-CCK-8 binding to rat cerebral cortex membranes at Cholecystokinin type B receptor.
ChEMBL 566 8 4 5 3.5 O=C(N[C@@H]1C[C@H]2c3[nH]c4ccccc4c3C[C@H](C(=O)N[C@H](Cc3ccccc3)C(=O)O)N2C1=O)OCc1ccccc1 10.1021/jm000959x
CHEMBL125897 24607 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
In vitro inhibition of [3H]propionyl-CCK-8 binding to rat cerebral cortex membranes at Cholecystokinin type B receptor.In vitro inhibition of [3H]propionyl-CCK-8 binding to rat cerebral cortex membranes at Cholecystokinin type B receptor.
ChEMBL 566 8 4 5 3.5 O=C(N[C@@H]1C[C@H]2c3[nH]c4ccccc4c3C[C@H](C(=O)N[C@H](Cc3ccccc3)C(=O)O)N2C1=O)OCc1ccccc1 10.1021/jm000959x
20190197 38293 0 None - 0 Human 4.4 pIC50 = 4.4 Binding
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 421 4 1 3 4.6 CN1c2ccccc2C(c2ccccc2F)=NCC1CNC(=O)c1ccc(Cl)cc1 10.1021/jm00163a069
CHEMBL140365 38293 0 None - 0 Human 4.4 pIC50 = 4.4 Binding
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 421 4 1 3 4.6 CN1c2ccccc2C(c2ccccc2F)=NCC1CNC(=O)c1ccc(Cl)cc1 10.1021/jm00163a069
11799462 168795 0 None - 0 Mouse 7.4 pIC50 = 7.4 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 497 6 3 6 5.3 CC(C)Oc1cccc(-n2c(NNC(=O)Nc3ccc(C(F)(F)F)cc3)nc3ccccc3c2=O)c1 10.1021/jm970373j
CHEMBL415965 168795 0 None - 0 Mouse 7.4 pIC50 = 7.4 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 497 6 3 6 5.3 CC(C)Oc1cccc(-n2c(NNC(=O)Nc3ccc(C(F)(F)F)cc3)nc3ccccc3c2=O)c1 10.1021/jm970373j
14843038 144986 0 None - 0 Mouse 7.4 pIC50 = 7.4 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 473 5 1 4 5.4 COc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
CHEMBL37699 144986 0 None - 0 Mouse 7.4 pIC50 = 7.4 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 473 5 1 4 5.4 COc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
44329306 116425 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 594 8 3 3 7.0 CCc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)NC3(C)CCCCC3)C2=O)c1 10.1016/S0960-894X(01)80832-5
CHEMBL322381 116425 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 594 8 3 3 7.0 CCc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)NC3(C)CCCCC3)C2=O)c1 10.1016/S0960-894X(01)80832-5
13953716 108374 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]gastrin from guinea pig gastric glandsDisplacement of [125I]gastrin from guinea pig gastric glands
ChEMBL 442 3 2 5 4.9 Cc1nnc2n1-c1ccccc1C(c1ccccc1)=NC2NC(=O)Nc1ccc(Cl)cc1 10.1021/jm00396a028
CHEMBL298705 108374 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]gastrin from guinea pig gastric glandsDisplacement of [125I]gastrin from guinea pig gastric glands
ChEMBL 442 3 2 5 4.9 Cc1nnc2n1-c1ccccc1C(c1ccccc1)=NC2NC(=O)Nc1ccc(Cl)cc1 10.1021/jm00396a028
13953715 201455 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]gastrin from guinea pig gastric glandsDisplacement of [125I]gastrin from guinea pig gastric glands
ChEMBL 428 3 2 5 4.6 O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2-n2cnnc21 10.1021/jm00396a028
CHEMBL53234 201455 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]gastrin from guinea pig gastric glandsDisplacement of [125I]gastrin from guinea pig gastric glands
ChEMBL 428 3 2 5 4.6 O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2-n2cnnc21 10.1021/jm00396a028
10048986 34327 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 442 5 3 4 3.4 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)O)C2=O)c1 10.1021/jm00078a018
CHEMBL136919 34327 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 442 5 3 4 3.4 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)O)C2=O)c1 10.1021/jm00078a018
44280495 105902 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 641 10 5 8 3.7 CN1C(=O)[C@H](NC(=O)Nc2cccc(C(=O)NCCSCc3csc(N=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
CHEMBL280980 105902 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 641 10 5 8 3.7 CN1C(=O)[C@H](NC(=O)Nc2cccc(C(=O)NCCSCc3csc(N=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
CHEMBL100609 215231 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL None None None COc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00173a006
44381578 127287 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptorDisplacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptor
ChEMBL 840 23 10 10 2.9 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(O)cc1)CNN[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80680-0
CHEMBL354512 127287 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptorDisplacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptor
ChEMBL 840 23 10 10 2.9 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(O)cc1)CNN[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80680-0
44381915 65830 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortexDisplacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortex
ChEMBL 454 15 2 3 5.4 CCCCCN(CCCCC)C(=O)[C@@H](CCCC(=O)O)NC(=O)c1ccc2ccccc2c1 10.1016/S0960-894X(00)80681-2
CHEMBL169466 65830 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortexDisplacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortex
ChEMBL 454 15 2 3 5.4 CCCCCN(CCCCC)C(=O)[C@@H](CCCC(=O)O)NC(=O)c1ccc2ccccc2c1 10.1016/S0960-894X(00)80681-2
14208208 176258 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 399 4 2 3 3.8 O=C(/C=C/c1ccccc1)NC1N=C(c2ccccc2F)c2ccccc2NC1=O 10.1021/jm00120a002
CHEMBL443009 176258 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 399 4 2 3 3.8 O=C(/C=C/c1ccccc1)NC1N=C(c2ccccc2F)c2ccccc2NC1=O 10.1021/jm00120a002
44349185 23303 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 421 7 3 4 3.0 O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NN1CCC2(CCCCC2)C1 10.1021/jm00079a003
CHEMBL123720 23303 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 421 7 3 4 3.0 O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NN1CCC2(CCCCC2)C1 10.1021/jm00079a003
CHEMBL169178 215616 0 None - 0 Mouse 4.4 pIC50 = 4.4 Binding
Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)
ChEMBL None None None CCOC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N1CC(=O)N[C@@H](Cc2ccccc2)C1 10.1016/S0960-894X(01)80253-5
14208315 74511 0 None - 0 Human 4.4 pIC50 = 4.4 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 495 3 1 3 3.9 CN1C(=O)[C@@H](NC(=O)c2ccccc2I)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
CHEMBL1907839 74511 0 None - 0 Human 4.4 pIC50 = 4.4 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 495 3 1 3 3.9 CN1C(=O)[C@@H](NC(=O)c2ccccc2I)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
10361419 33226 13 None - 0 Human 4.4 pIC50 = 4.4 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 364 2 2 3 2.9 CN1C(=O)C(NC(=O)NC(C)(C)C)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL135988 33226 13 None - 0 Human 4.4 pIC50 = 4.4 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 364 2 2 3 2.9 CN1C(=O)C(NC(=O)NC(C)(C)C)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
145982146 173357 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting methodDisplacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting method
ChEMBL 415 3 2 6 3.8 O=C1Nc2ccccc2/C1=N/Nc1nc2ccccc2c(=O)n1-c1cccc(Cl)c1 10.1039/C7MD00171A
CHEMBL4279998 173357 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting methodDisplacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting method
ChEMBL 415 3 2 6 3.8 O=C1Nc2ccccc2/C1=N/Nc1nc2ccccc2c(=O)n1-c1cccc(Cl)c1 10.1039/C7MD00171A
CHEMBL333299 218170 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Compound was tested for its inhibitory activity in cortical cholecystokinin type B receptor in guinea pigCompound was tested for its inhibitory activity in cortical cholecystokinin type B receptor in guinea pig
ChEMBL None None None C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00105a068
44280729 175008 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 644 12 4 5 4.3 O=C(CC(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O)NCc1ccccc1 10.1021/jm950372w
CHEMBL433621 175008 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 644 12 4 5 4.3 O=C(CC(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O)NCc1ccccc1 10.1021/jm950372w
19766221 125667 0 None - 0 Human 4.4 pIC50 = 4.4 Binding
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 569 7 3 5 5.2 CN1c2ccccc2C(c2ccccc2F)=NCC1CNC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00163a069
CHEMBL342256 125667 0 None - 0 Human 4.4 pIC50 = 4.4 Binding
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 569 7 3 5 5.2 CN1c2ccccc2C(c2ccccc2F)=NCC1CNC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00163a069
10793952 109558 0 None - 1 Rat 6.4 pIC50 = 6.4 Binding
Inhibitory activity against CCK-B receptorInhibitory activity against CCK-B receptor
ChEMBL 621 8 3 5 5.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1C[C@H](Oc2ccc(F)cc2F)C[C@@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
CHEMBL30524 109558 0 None - 1 Rat 6.4 pIC50 = 6.4 Binding
Inhibitory activity against CCK-B receptorInhibitory activity against CCK-B receptor
ChEMBL 621 8 3 5 5.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1C[C@H](Oc2ccc(F)cc2F)C[C@@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
44280163 111150 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 658 12 3 5 4.7 CN(Cc1ccccc1)C(=O)[C@H](CC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL31018 111150 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 658 12 3 5 4.7 CN(Cc1ccccc1)C(=O)[C@H](CC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
5311201 214174 35 None -234 6 Rat 7.4 pIC50 = 7.4 Binding
Inhibitory activity against CCK-B receptorInhibitory activity against CCK-B receptor
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/s0960-894x(98)00231-5
CHEMBL9387 214174 35 None -234 6 Rat 7.4 pIC50 = 7.4 Binding
Inhibitory activity against CCK-B receptorInhibitory activity against CCK-B receptor
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/s0960-894x(98)00231-5
10553146 123491 0 None - 0 Mouse 7.4 pIC50 = 7.4 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 6 3 3 5.7 CC1CCCCC1NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1021/jm970065l
CHEMBL337310 123491 0 None - 0 Mouse 7.4 pIC50 = 7.4 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 6 3 3 5.7 CC1CCCCC1NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1021/jm970065l
CHEMBL433398 220418 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL None None None CC(C)(C)OC(=O)N1c2ccccc2C[C@@H]1C(=O)N1[C@H](c2ccccc2)CC[C@@H]1C(=O)N1Cc2ccccc2C[C@@H]1C(=O)O 10.1016/S0960-894X(96)00546-X
10722372 126359 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Concentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cellsConcentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL 605 8 3 5 5.0 CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccc(C(=O)O)cc1 10.1021/jm950626d
CHEMBL346179 126359 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Concentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cellsConcentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL 605 8 3 5 5.0 CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccc(C(=O)O)cc1 10.1021/jm950626d
11497371 77405 0 None - 3 Dog 7.4 pIC50 = 7.4 Binding
Concentration required to inhibit the binding of [125I]-BH-CCK-8S radioligand to canine gastric mucosa CCK2 receptorConcentration required to inhibit the binding of [125I]-BH-CCK-8S radioligand to canine gastric mucosa CCK2 receptor
ChEMBL 525 7 3 3 7.4 Cc1cc(C)c(-c2nc(C(=O)Nc3ccc(C)c(C(=O)O)c3)c(CCC34CC5CC(CC(C5)C3)C4)[nH]2)c(C)c1 10.1021/jm0490686
CHEMBL195007 77405 0 None - 3 Dog 7.4 pIC50 = 7.4 Binding
Concentration required to inhibit the binding of [125I]-BH-CCK-8S radioligand to canine gastric mucosa CCK2 receptorConcentration required to inhibit the binding of [125I]-BH-CCK-8S radioligand to canine gastric mucosa CCK2 receptor
ChEMBL 525 7 3 3 7.4 Cc1cc(C)c(-c2nc(C(=O)Nc3ccc(C)c(C(=O)O)c3)c(CCC34CC5CC(CC(C5)C3)C4)[nH]2)c(C)c1 10.1021/jm0490686
14208228 109884 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 470 5 3 4 3.3 O=C(O)CN1C(=O)C(NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL307661 109884 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 470 5 3 4 3.3 O=C(O)CN1C(=O)C(NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
14208303 211470 1 None - 0 Human 6.4 pIC50 = 6.4 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 513 3 1 3 4.0 CN1C(=O)C(NC(=O)c2cccc(I)c2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL73946 211470 1 None - 0 Human 6.4 pIC50 = 6.4 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 513 3 1 3 4.0 CN1C(=O)C(NC(=O)c2cccc(I)c2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
44280507 120273 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 573 9 3 4 5.0 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(C(=O)O)c1ccccc1 10.1021/jm950372w
CHEMBL33200 120273 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 573 9 3 4 5.0 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(C(=O)O)c1ccccc1 10.1021/jm950372w
44334278 11472 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 515 9 2 4 5.5 Cc1cccc(NC(=O)N[C@H](CSCc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
CHEMBL103457 11472 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 515 9 2 4 5.5 Cc1cccc(NC(=O)N[C@H](CSCc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
CHEMBL407530 219446 0 None - 0 Bovine 5.4 pIC50 = 5.4 Binding
Concentration inhibiting [3H]propionyl-CCK-8 binding to cholecystokinin type B receptor of bovine striatum.Concentration inhibiting [3H]propionyl-CCK-8 binding to cholecystokinin type B receptor of bovine striatum.
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00100a033
14208202 211421 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 443 4 2 4 4.5 O=C(Cc1cccc2sccc12)NC1N=C(c2ccccc2F)c2ccccc2NC1=O 10.1021/jm00120a002
CHEMBL73563 211421 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 443 4 2 4 4.5 O=C(Cc1cccc2sccc12)NC1N=C(c2ccccc2F)c2ccccc2NC1=O 10.1021/jm00120a002
44334434 11863 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 483 8 2 3 5.2 Cc1cccc(NC(=O)N[C@H](CCc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
CHEMBL105527 11863 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 483 8 2 3 5.2 Cc1cccc(NC(=O)N[C@H](CCc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
CHEMBL171310 215626 0 None - 0 Mouse 4.4 pIC50 = 4.4 Binding
Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N1CC(=O)N[C@H](Cc2ccccc2)C1 10.1016/S0960-894X(01)80253-5
14720389 171862 0 None - 0 Human 4.4 pIC50 = 4.4 Binding
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 373 10 3 3 2.8 CCCN(CCC)C(=O)[C@H](CCC(=O)O)NC(=O)c1cc2ccccc2[nH]1 10.1021/jm00164a020
CHEMBL422701 171862 0 None - 0 Human 4.4 pIC50 = 4.4 Binding
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 373 10 3 3 2.8 CCCN(CCC)C(=O)[C@H](CCC(=O)O)NC(=O)c1cc2ccccc2[nH]1 10.1021/jm00164a020
44283029 106830 0 None - 0 Mouse 6.4 pIC50 = 6.4 Binding
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 627 11 3 7 5.2 COC(=O)/C=C/C(=O)N[C@H](COC(=O)C(C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)c1ccccc1 10.1021/jm00086a017
CHEMBL287079 106830 0 None - 0 Mouse 6.4 pIC50 = 6.4 Binding
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 627 11 3 7 5.2 COC(=O)/C=C/C(=O)N[C@H](COC(=O)C(C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)c1ccccc1 10.1021/jm00086a017
CHEMBL2369373 216383 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes
ChEMBL None None None CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccc(C)cc1)C(N)=O 10.1021/jm00001a027
44408524 162484 0 None -158 4 Human 5.4 pIC50 = 5.4 Binding
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1134 30 12 15 2.6 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)C(=O)O 10.1021/jm050851n
CHEMBL405192 162484 0 None -158 4 Human 5.4 pIC50 = 5.4 Binding
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1134 30 12 15 2.6 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)C(=O)O 10.1021/jm050851n
9985100 121280 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 552 5 3 3 6.0 CC(C)(C)NC(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](c2cccc(Cl)c2)c2ccccc21 10.1021/jm00048a015
CHEMBL333541 121280 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 552 5 3 3 6.0 CC(C)(C)NC(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](c2cccc(Cl)c2)c2ccccc21 10.1021/jm00048a015
44368522 126259 0 None - 0 Mouse 8.4 pIC50 = 8.4 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 574 11 5 5 4.4 C[C@H]1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)NC[C@H](NC(=O)/C=C/C(=O)O)c1ccccc1 10.1021/jm00057a005
CHEMBL345303 126259 0 None - 0 Mouse 8.4 pIC50 = 8.4 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 574 11 5 5 4.4 C[C@H]1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)NC[C@H](NC(=O)/C=C/C(=O)O)c1ccccc1 10.1021/jm00057a005
5311201 214174 35 None -27 6 Human 8.4 pIC50 = 8.4 Binding
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL9387 214174 35 None -27 6 Human 8.4 pIC50 = 8.4 Binding
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL432671 174874 0 None - 1 Human 8.4 pIC50 = 8.4 Binding
Inhibitory activity against gastrin receptor.Inhibitory activity against gastrin receptor.
ChEMBL 784 15 7 12 3.1 CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCNC(=O)CC(=O)NCCSCc3csc(C=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
5311201 214174 35 None -27 6 Human 8.4 pIC50 = 8.4 Binding
Inhibitory activity against gastrin receptor.Inhibitory activity against gastrin receptor.
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00249-1
CHEMBL9387 214174 35 None -27 6 Human 8.4 pIC50 = 8.4 Binding
Inhibitory activity against gastrin receptor.Inhibitory activity against gastrin receptor.
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00249-1
5311201 214174 35 None -27 6 Human 8.4 pIC50 = 8.4 Binding
Inhibitory concentration against gastrin receptorInhibitory concentration against gastrin receptor
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm058225d
CHEMBL9387 214174 35 None -27 6 Human 8.4 pIC50 = 8.4 Binding
Inhibitory concentration against gastrin receptorInhibitory concentration against gastrin receptor
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm058225d
101823779 8178 35 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b01558
16162108 8178 35 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b01558
8408 8178 35 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b01558
CHEMBL4451154 8178 35 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b01558
10075014 169760 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 508 6 2 5 4.4 CCOC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00121a004
CHEMBL417521 169760 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 508 6 2 5 4.4 CCOC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00121a004
44300862 164651 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 695 9 4 6 5.2 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)NS(=O)(=O)Cc3ccccc3)c1)C[C@@H]2c1ccccc1 10.1016/0960-894X(95)00327-P
CHEMBL408392 164651 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 695 9 4 6 5.2 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)NS(=O)(=O)Cc3ccccc3)c1)C[C@@H]2c1ccccc1 10.1016/0960-894X(95)00327-P
14802520 123071 1 None - 0 Mouse 8.4 pIC50 = 8.4 Binding
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptor
ChEMBL 628 13 5 5 4.7 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](CNC(=O)CCC(=O)O)Cc1ccccc1 10.1021/jm00105a062
CHEMBL335914 123071 1 None - 0 Mouse 8.4 pIC50 = 8.4 Binding
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptor
ChEMBL 628 13 5 5 4.7 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](CNC(=O)CCC(=O)O)Cc1ccccc1 10.1021/jm00105a062
14802520 127138 1 None - 1 Mouse 8.4 pIC50 = 8.4 Binding
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 628 13 5 5 4.7 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CNC(=O)CCC(=O)O)Cc1ccccc1 10.1016/S0960-894X(00)80685-X
CHEMBL353157 127138 1 None - 1 Mouse 8.4 pIC50 = 8.4 Binding
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 628 13 5 5 4.7 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CNC(=O)CCC(=O)O)Cc1ccccc1 10.1016/S0960-894X(00)80685-X
10074366 127376 0 None - 0 Mouse 8.4 pIC50 = 8.4 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 9 4 4 4.5 C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
CHEMBL3349028 127376 0 None - 0 Mouse 8.4 pIC50 = 8.4 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 9 4 4 4.5 C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
CHEMBL3545866 127376 0 None - 0 Mouse 8.4 pIC50 = 8.4 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 9 4 4 4.5 C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
44368612 128774 0 None - 0 Mouse 8.4 pIC50 = 8.4 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 612 13 5 4 4.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)C1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CNC(=O)CCC(=O)O)Cc1ccccc1 10.1021/jm00057a005
CHEMBL359361 128774 0 None - 0 Mouse 8.4 pIC50 = 8.4 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 612 13 5 4 4.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)C1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CNC(=O)CCC(=O)O)Cc1ccccc1 10.1021/jm00057a005
136242438 85401 0 None - 0 Mouse 8.4 pIC50 = 8.4 Binding
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 671 12 6 7 4.2 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CSc1n[nH]c(=O)[nH]1)c1ccccc1 10.1021/jm00092a007
CHEMBL2112333 85401 0 None - 0 Mouse 8.4 pIC50 = 8.4 Binding
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 671 12 6 7 4.2 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CSc1n[nH]c(=O)[nH]1)c1ccccc1 10.1021/jm00092a007
10481751 119868 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 518 5 3 3 5.3 CC(C)(C)NC(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](c2ccccc2)c2ccccc21 10.1021/jm00048a015
CHEMBL331315 119868 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 518 5 3 3 5.3 CC(C)(C)NC(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](c2ccccc2)c2ccccc21 10.1021/jm00048a015
CHEMBL438773 220576 0 None - 0 Bovine 8.4 pIC50 = 8.4 Binding
Concentration inhibiting [3H]propionyl-CCK-8 binding to cholecystokinin type B receptor of bovine striatum.Concentration inhibiting [3H]propionyl-CCK-8 binding to cholecystokinin type B receptor of bovine striatum.
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00100a033
CHEMBL2370122 216566 0 None - 0 Bovine 8.4 pIC50 = 8.4 Binding
Inhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranesInhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranes
ChEMBL None None None CSCC[C@@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00107a037
CHEMBL267849 217513 0 None - 0 Bovine 8.4 pIC50 = 8.4 Binding
Inhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatumInhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatum
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00099a005
10030203 32662 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 540 6 2 6 2.8 COc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)N3CCN(C)CC3)C2=O)c1 10.1021/jm00078a018
CHEMBL135371 32662 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 540 6 2 6 2.8 COc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)N3CCN(C)CC3)C2=O)c1 10.1021/jm00078a018
15281997 55276 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligandBinding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligand
ChEMBL 486 5 2 6 3.7 Cc1cccc(NC(=O)NC2N=C(c3nccn3C)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1016/0960-894X(95)00557-A
CHEMBL155627 55276 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligandBinding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligand
ChEMBL 486 5 2 6 3.7 Cc1cccc(NC(=O)NC2N=C(c3nccn3C)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1016/0960-894X(95)00557-A
14802528 125243 0 None - 0 Mouse 8.3 pIC50 = 8.3 Binding
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptor
ChEMBL 642 14 5 5 5.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](CNC(=O)CCCC(=O)O)Cc1ccccc1 10.1021/jm00105a062
CHEMBL341281 125243 0 None - 0 Mouse 8.3 pIC50 = 8.3 Binding
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptor
ChEMBL 642 14 5 5 5.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](CNC(=O)CCCC(=O)O)Cc1ccccc1 10.1021/jm00105a062
10720403 126208 0 None - 0 Mouse 8.3 pIC50 = 8.3 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 507 6 4 4 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H]1CCCCC[C@H]1O 10.1021/jm970065l
CHEMBL344882 126208 0 None - 0 Mouse 8.3 pIC50 = 8.3 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 507 6 4 4 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H]1CCCCC[C@H]1O 10.1021/jm970065l
CHEMBL336381 218362 0 None 97 5 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
44300864 208698 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 681 8 4 6 5.1 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)NS(=O)(=O)c3ccccc3)c1)C[C@@H]2c1ccccc1 10.1016/0960-894X(95)00327-P
CHEMBL60754 208698 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 681 8 4 6 5.1 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)NS(=O)(=O)c3ccccc3)c1)C[C@@H]2c1ccccc1 10.1016/0960-894X(95)00327-P
56663037 70708 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]CCK from gastrin receptor isolated from human tumor tissuesDisplacement of [125I]CCK from gastrin receptor isolated from human tumor tissues
ChEMBL 1802 69 14 31 -2.7 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm101279a
CHEMBL1806529 70708 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]CCK from gastrin receptor isolated from human tumor tissuesDisplacement of [125I]CCK from gastrin receptor isolated from human tumor tissues
ChEMBL 1802 69 14 31 -2.7 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm101279a
44356710 123389 8 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 426 4 2 4 3.9 CC(=O)c1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
CHEMBL336765 123389 8 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 426 4 2 4 3.9 CC(=O)c1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
CHEMBL2369769 216464 0 None - 0 Mouse 8.3 pIC50 = 8.3 Binding
Concentration producing half-maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortexConcentration producing half-maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL None None None C/C=C/CC[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/0960-894X(94)85022-4
44333624 11358 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortexDisplacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortex
ChEMBL 462 5 2 5 3.1 CCCN1C(=O)C(NC(=O)Nc2cccc(CC)c2)N=C(N2CCN(C)CC2)c2ccccc21 10.1016/0960-894X(95)00530-0
CHEMBL102633 11358 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortexDisplacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortex
ChEMBL 462 5 2 5 3.1 CCCN1C(=O)C(NC(=O)Nc2cccc(CC)c2)N=C(N2CCN(C)CC2)c2ccccc21 10.1016/0960-894X(95)00530-0
19018661 35256 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 442 5 3 4 3.3 CN1C(=O)C(NC(=O)Nc2cccc(CC(=O)O)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL137567 35256 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 442 5 3 4 3.3 CN1C(=O)C(NC(=O)Nc2cccc(CC(=O)O)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
10430103 85289 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 384 3 3 3 3.9 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3NC2=O)c1 10.1021/jm00078a018
CHEMBL2111921 85289 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 384 3 3 3 3.9 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3NC2=O)c1 10.1021/jm00078a018
44280269 105993 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 626 10 4 4 5.3 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm950372w
CHEMBL281559 105993 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 626 10 4 4 5.3 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm950372w
44329520 114188 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 574 7 3 3 6.9 Cc1ccc(NC(=O)CN2C(=O)[C@H](NC(=O)Nc3cccc(C)c3)C[C@H](c3ccccc3C)C[C@@H]2c2ccccc2)cc1 10.1016/S0960-894X(01)80832-5
CHEMBL318024 114188 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 574 7 3 3 6.9 Cc1ccc(NC(=O)CN2C(=O)[C@H](NC(=O)Nc3cccc(C)c3)C[C@H](c3ccccc3C)C[C@@H]2c2ccccc2)cc1 10.1016/S0960-894X(01)80832-5
44327421 162486 0 None - 0 Mouse 7.4 pIC50 = 7.4 Binding
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 557 10 3 4 5.2 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccc1)CC(=O)O 10.1016/S0960-894X(01)80769-1
CHEMBL405208 162486 0 None - 0 Mouse 7.4 pIC50 = 7.4 Binding
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 557 10 3 4 5.2 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccc1)CC(=O)O 10.1016/S0960-894X(01)80769-1
44349082 24547 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 446 9 3 3 4.0 O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NCCC12CC3CC(CC(C3)C1)C2 10.1021/jm00079a003
CHEMBL125874 24547 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 446 9 3 3 4.0 O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NCCC12CC3CC(CC(C3)C1)C2 10.1021/jm00079a003
44349074 123814 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 426 7 4 4 2.8 O=C(O)CCC(NC(=O)c1cc2ccccc2[nH]1)C(=O)NN1CCC2(CCCC2)CC1 10.1021/jm00079a003
CHEMBL339041 123814 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 426 7 4 4 2.8 O=C(O)CCC(NC(=O)c1cc2ccccc2[nH]1)C(=O)NN1CCC2(CCCC2)CC1 10.1021/jm00079a003
44348887 124867 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 469 7 3 4 4.0 O=C(O)CCC(NC(=O)c1ccc(Cl)c(Cl)c1)C(=O)NN1CCC2(CCCCC2)CC1 10.1021/jm00079a003
CHEMBL340630 124867 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 469 7 3 4 4.0 O=C(O)CCC(NC(=O)c1ccc(Cl)c(Cl)c1)C(=O)NN1CCC2(CCCCC2)CC1 10.1021/jm00079a003
44280215 106606 0 None - 1 Mouse 6.4 pIC50 = 6.4 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 756 15 6 10 3.3 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCC(=O)NCCSCc4csc(N=C(N)N)n4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL285586 106606 0 None - 1 Mouse 6.4 pIC50 = 6.4 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 756 15 6 10 3.3 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCC(=O)NCCSCc4csc(N=C(N)N)n4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
44281204 106626 0 None - 1 Mouse 6.4 pIC50 = 6.4 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 871 18 4 10 5.5 CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCCCN3CCN(C(=O)CNCCCOc4cccc(CN5CCCCC5)c4)CC3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
CHEMBL285719 106626 0 None - 1 Mouse 6.4 pIC50 = 6.4 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 871 18 4 10 5.5 CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCCCN3CCN(C(=O)CNCCCOc4cccc(CN5CCCCC5)c4)CC3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
44381949 127502 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Tested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pigTested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pig
ChEMBL 474 3 3 4 4.6 CN1C(=O)[C@H](NC(=O)Nc2cc3c4ccccc4nc-3c[nH]2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80682-4
CHEMBL354802 127502 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Tested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pigTested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pig
ChEMBL 474 3 3 4 4.6 CN1C(=O)[C@H](NC(=O)Nc2cc3c4ccccc4nc-3c[nH]2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80682-4
CHEMBL290818 217658 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Binding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cellsBinding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cells
ChEMBL None None None CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00001a019
14208192 109773 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 394 3 3 3 3.7 O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1cc2ccccc2[nH]1 10.1021/jm00120a002
CHEMBL306760 109773 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 394 3 3 3 3.7 O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1cc2ccccc2[nH]1 10.1021/jm00120a002
44375446 63056 0 None - 0 Mouse 5.4 pIC50 = 5.4 Binding
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 644 12 5 7 5.6 O=C(O)c1cccc(N(Cc2ccccc2)S(=O)(=O)c2ccc(N/N=C(/S)NCCc3c[nH]c4ccccc34)c([N+](=O)[O-])c2)c1 10.1016/s0960-894x(01)00044-0
CHEMBL162947 63056 0 None - 0 Mouse 5.4 pIC50 = 5.4 Binding
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 644 12 5 7 5.6 O=C(O)c1cccc(N(Cc2ccccc2)S(=O)(=O)c2ccc(N/N=C(/S)NCCc3c[nH]c4ccccc34)c([N+](=O)[O-])c2)c1 10.1016/s0960-894x(01)00044-0
90663979 113586 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 883 23 8 10 3.3 COc1ccc(/C=C\C(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1OC 10.1021/jm00089a010
CHEMBL3144548 113586 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 883 23 8 10 3.3 COc1ccc(/C=C\C(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1OC 10.1021/jm00089a010
44281005 123509 0 None - 1 Mouse 5.4 pIC50 = 5.4 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 787 17 4 8 6.4 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CCOC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 10.1016/S0960-894X(96)00249-1
CHEMBL33743 123509 0 None - 1 Mouse 5.4 pIC50 = 5.4 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 787 17 4 8 6.4 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CCOC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 10.1016/S0960-894X(96)00249-1
14208264 108886 0 None - 0 Human 4.4 pIC50 = 4.4 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 411 3 2 3 4.5 CC(C)(C)c1ccc(C(=O)NC2N=C(c3ccccc3)c3ccccc3NC2=O)cc1 10.1021/jm00120a002
CHEMBL302282 108886 0 None - 0 Human 4.4 pIC50 = 4.4 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 411 3 2 3 4.5 CC(C)(C)c1ccc(C(=O)NC2N=C(c3ccccc3)c3ccccc3NC2=O)cc1 10.1021/jm00120a002
14208243 211196 0 None - 0 Human 4.4 pIC50 = 4.4 Binding
Tested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brainTested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL 403 3 1 3 3.9 CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80682-4
CHEMBL72073 211196 0 None - 0 Human 4.4 pIC50 = 4.4 Binding
Tested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brainTested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL 403 3 1 3 3.9 CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80682-4
44283132 127579 0 None - 0 Mouse 5.4 pIC50 = 5.4 Binding
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 485 9 3 3 5.9 CC(CNCCc1ccccc1)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
CHEMBL35555 127579 0 None - 0 Mouse 5.4 pIC50 = 5.4 Binding
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 485 9 3 3 5.9 CC(CNCCc1ccccc1)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
10717652 112934 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 433 5 3 4 3.8 CCCN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C([C@@H]2CCCCN2)c2ccccc21 10.1021/jm9608523
CHEMBL313653 112934 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 433 5 3 4 3.8 CCCN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C([C@@H]2CCCCN2)c2ccccc21 10.1021/jm9608523
10070678 127533 1 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 418 3 2 3 4.3 CN1C(=O)[C@@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00121a004
CHEMBL355092 127533 1 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 418 3 2 3 4.3 CN1C(=O)[C@@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00121a004
15637181 35213 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 533 9 3 5 4.4 CCN(CC)C[C@H](O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL137535 35213 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 533 9 3 5 4.4 CCN(CC)C[C@H](O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
44334176 11842 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 527 9 2 5 4.7 Cc1cccc(NC(=O)N[C@H](CC(=O)OCc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
CHEMBL105404 11842 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 527 9 2 5 4.7 Cc1cccc(NC(=O)N[C@H](CC(=O)OCc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
10070678 127533 1 None - 0 Human 6.4 pIC50 = 6.4 Binding
Tested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brainTested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL 418 3 2 3 4.3 CN1C(=O)[C@@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80682-4
CHEMBL355092 127533 1 None - 0 Human 6.4 pIC50 = 6.4 Binding
Tested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brainTested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL 418 3 2 3 4.3 CN1C(=O)[C@@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80682-4
15104624 16772 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 514 13 2 4 5.7 CCCCCN(CCCCC)C(=O)[C@@H](CC1C(=O)Nc2ccccc21)NC(=O)c1cnc2ccccc2c1 10.1021/jm00116a002
CHEMBL114913 16772 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 514 13 2 4 5.7 CCCCCN(CCCCC)C(=O)[C@@H](CC1C(=O)Nc2ccccc21)NC(=O)c1cnc2ccccc2c1 10.1021/jm00116a002
44370497 171972 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 453 8 3 3 4.6 O=C(O)CC[C@H](NC(=O)c1cc2ccccc2[nH]1)C(=O)N(C1CCCCC1)C1CCCCC1 10.1021/jm00164a020
CHEMBL422873 171972 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 453 8 3 3 4.6 O=C(O)CC[C@H](NC(=O)c1cc2ccccc2[nH]1)C(=O)N(C1CCCCC1)C1CCCCC1 10.1021/jm00164a020
10010723 11685 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL 836 20 8 7 3.1 Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C(F)(F)F)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
CHEMBL104598 11685 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL 836 20 8 7 3.1 Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C(F)(F)F)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
73345199 148523 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Inhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic aciniInhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic acini
ChEMBL 1019 29 9 11 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCOc1ccccc1)CC(=O)O 10.1021/jm00072a024
CHEMBL385918 148523 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Inhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic aciniInhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic acini
ChEMBL 1019 29 9 11 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCOc1ccccc1)CC(=O)O 10.1021/jm00072a024
57393204 74463 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 431 5 1 4 3.3 COc1cccc(CC(=O)N[C@H]2N=C(c3ccccc3F)c3ccccc3N(C)C2=O)c1 10.1021/jm00120a002
CHEMBL1907666 74463 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 431 5 1 4 3.3 COc1cccc(CC(=O)N[C@H]2N=C(c3ccccc3F)c3ccccc3N(C)C2=O)c1 10.1021/jm00120a002
14208313 74514 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 437 3 1 3 4.3 CN1C(=O)[C@H](NC(=O)c2ccc(C(F)(F)F)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
CHEMBL1907842 74514 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 437 3 1 3 4.3 CN1C(=O)[C@H](NC(=O)c2ccc(C(F)(F)F)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
9914964 16403 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 530 13 4 5 5.7 CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cc(O)c2cccc(O)c2n1 10.1021/jm00116a002
CHEMBL112682 16403 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 530 13 4 5 5.7 CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cc(O)c2cccc(O)c2n1 10.1021/jm00116a002
44381719 65644 0 None - 0 Human 4.4 pIC50 = 4.4 Binding
Displacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortexDisplacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortex
ChEMBL 558 12 3 5 3.4 O=C(CCC(NC(=O)c1cccc(Cl)c1)C(=O)NCCC12CC3CC(CC(C3)C1)C2)NCCN1CCOCC1 10.1016/S0960-894X(00)80681-2
CHEMBL168855 65644 0 None - 0 Human 4.4 pIC50 = 4.4 Binding
Displacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortexDisplacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortex
ChEMBL 558 12 3 5 3.4 O=C(CCC(NC(=O)c1cccc(Cl)c1)C(=O)NCCC12CC3CC(CC(C3)C1)C2)NCCN1CCOCC1 10.1016/S0960-894X(00)80681-2
10463229 126587 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
In vitro ability to inhibit [125I]Bolton-Hunter-CCK-8 binding to Cholecystokinin type B receptor in guinea pig cortexIn vitro ability to inhibit [125I]Bolton-Hunter-CCK-8 binding to Cholecystokinin type B receptor in guinea pig cortex
ChEMBL 840 20 9 8 3.8 CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCNC(=O)Nc1ccccc1C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00031a013
CHEMBL348346 126587 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
In vitro ability to inhibit [125I]Bolton-Hunter-CCK-8 binding to Cholecystokinin type B receptor in guinea pig cortexIn vitro ability to inhibit [125I]Bolton-Hunter-CCK-8 binding to Cholecystokinin type B receptor in guinea pig cortex
ChEMBL 840 20 9 8 3.8 CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCNC(=O)Nc1ccccc1C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00031a013
44303722 107626 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Compound was tested for its binding affinity towards Cholecystokinin type B receptor in cortical membranes (CNS)Compound was tested for its binding affinity towards Cholecystokinin type B receptor in cortical membranes (CNS)
ChEMBL 807 20 5 11 4.8 CCCC[C@@H](C(=O)N[C@@H](CC(=O)OCc1ccccc1)[C@@H](Cc1ccccc1)C(N)=O)n1nnnc1[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)OC(C)(C)C 10.1016/S0960-894X(01)81005-2
CHEMBL293456 107626 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Compound was tested for its binding affinity towards Cholecystokinin type B receptor in cortical membranes (CNS)Compound was tested for its binding affinity towards Cholecystokinin type B receptor in cortical membranes (CNS)
ChEMBL 807 20 5 11 4.8 CCCC[C@@H](C(=O)N[C@@H](CC(=O)OCc1ccccc1)[C@@H](Cc1ccccc1)C(N)=O)n1nnnc1[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)OC(C)(C)C 10.1016/S0960-894X(01)81005-2
10056407 126926 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro ability to inhibit [125I]Bolton-Hunter-CCK-8 binding to Cholecystokinin type B receptor in guinea pig cortexIn vitro ability to inhibit [125I]Bolton-Hunter-CCK-8 binding to Cholecystokinin type B receptor in guinea pig cortex
ChEMBL 854 20 7 8 4.2 Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00031a013
CHEMBL351364 126926 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro ability to inhibit [125I]Bolton-Hunter-CCK-8 binding to Cholecystokinin type B receptor in guinea pig cortexIn vitro ability to inhibit [125I]Bolton-Hunter-CCK-8 binding to Cholecystokinin type B receptor in guinea pig cortex
ChEMBL 854 20 7 8 4.2 Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00031a013
44280234 109062 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 658 13 4 5 4.7 O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NCc1ccccc1 10.1021/jm950372w
CHEMBL30335 109062 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 658 13 4 5 4.7 O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NCc1ccccc1 10.1021/jm950372w
10762723 103805 0 None - 0 Mouse 5.4 pIC50 = 5.4 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 386 4 3 6 3.2 Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccnc2)c1 10.1021/jm970373j
CHEMBL266819 103805 0 None - 0 Mouse 5.4 pIC50 = 5.4 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 386 4 3 6 3.2 Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccnc2)c1 10.1021/jm970373j
71452652 85279 0 None - 0 Mouse 7.4 pIC50 = 7.4 Binding
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 628 13 5 5 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCC[C@H](NC(=O)CCC(=O)O)c1ccccc1 10.1021/jm00105a062
CHEMBL2111884 85279 0 None - 0 Mouse 7.4 pIC50 = 7.4 Binding
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 628 13 5 5 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCC[C@H](NC(=O)CCC(=O)O)c1ccccc1 10.1021/jm00105a062
10346551 121414 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 518 5 3 3 5.3 CC(C)(C)NC(=O)CN1C(=O)[C@H](NC(=O)Nc2ccc(Cl)cc2)C[C@H](c2ccccc2)c2ccccc21 10.1021/jm00048a015
CHEMBL333813 121414 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 518 5 3 3 5.3 CC(C)(C)NC(=O)CN1C(=O)[C@H](NC(=O)Nc2ccc(Cl)cc2)C[C@H](c2ccccc2)c2ccccc21 10.1021/jm00048a015
14802538 103464 0 None - 0 Mouse 7.4 pIC50 = 7.4 Binding
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 614 12 5 5 4.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCC(=O)O)c1ccccc1 10.1016/S0960-894X(00)80685-X
CHEMBL263969 103464 0 None - 0 Mouse 7.4 pIC50 = 7.4 Binding
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 614 12 5 5 4.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCC(=O)O)c1ccccc1 10.1016/S0960-894X(00)80685-X
14802538 103464 0 None - 0 Mouse 7.4 pIC50 = 7.4 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 614 12 5 5 4.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCC(=O)O)c1ccccc1 10.1021/jm970065l
CHEMBL263969 103464 0 None - 0 Mouse 7.4 pIC50 = 7.4 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 614 12 5 5 4.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCC(=O)O)c1ccccc1 10.1021/jm970065l
136056456 212522 0 None - 0 Mouse 6.4 pIC50 = 6.4 Binding
Evaluated for inhibition of [125I]CCK-8S binding to cholecystokinin CCK-B receptor from mouse brain membranes at a concentration of 10 uM (in vitro)Evaluated for inhibition of [125I]CCK-8S binding to cholecystokinin CCK-B receptor from mouse brain membranes at a concentration of 10 uM (in vitro)
ChEMBL 421 5 1 4 5.8 CC(C)Oc1cccc(-n2c(/C=C/c3c[nH]c4ccccc34)nc3ccccc3c2=O)c1 10.1021/jm00092a003
CHEMBL82690 212522 0 None - 0 Mouse 6.4 pIC50 = 6.4 Binding
Evaluated for inhibition of [125I]CCK-8S binding to cholecystokinin CCK-B receptor from mouse brain membranes at a concentration of 10 uM (in vitro)Evaluated for inhibition of [125I]CCK-8S binding to cholecystokinin CCK-B receptor from mouse brain membranes at a concentration of 10 uM (in vitro)
ChEMBL 421 5 1 4 5.8 CC(C)Oc1cccc(-n2c(/C=C/c3c[nH]c4ccccc34)nc3ccccc3c2=O)c1 10.1021/jm00092a003
44370393 126422 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 492 14 2 3 5.4 CCCCCN(CCCCC)C(=O)C(CCC(=O)N1CCCC1)NC(=O)Nc1ccc(Cl)cc1 10.1021/jm00164a020
CHEMBL346784 126422 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 492 14 2 3 5.4 CCCCCN(CCCCC)C(=O)C(CCC(=O)N1CCCC1)NC(=O)Nc1ccc(Cl)cc1 10.1021/jm00164a020
44280714 106809 0 None - 1 Mouse 6.4 pIC50 = 6.4 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 726 14 6 9 3.2 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCC(=O)NCCSCc3csc(N=C(N)N)n3)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL286908 106809 0 None - 1 Mouse 6.4 pIC50 = 6.4 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 726 14 6 9 3.2 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCC(=O)NCCSCc3csc(N=C(N)N)n3)C2=O)c1 10.1016/S0960-894X(96)00248-X
108187 7713 37 None -9 5 Mouse 5.4 pIC50 = 5.4 Binding
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm00086a017
873 7713 37 None -9 5 Mouse 5.4 pIC50 = 5.4 Binding
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm00086a017
CHEMBL2062154 7713 37 None -9 5 Mouse 5.4 pIC50 = 5.4 Binding
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm00086a017
CHEMBL287735 7713 37 None -9 5 Mouse 5.4 pIC50 = 5.4 Binding
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm00086a017
14991567 206579 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 847 20 8 8 4.0 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1cccc2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL59404 206579 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 847 20 8 8 4.0 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1cccc2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
44280973 106643 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 704 12 4 5 5.9 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NC1CCC2CCCCC2C1 10.1021/jm950372w
CHEMBL285857 106643 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 704 12 4 5 5.9 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NC1CCC2CCCCC2C1 10.1021/jm950372w
44361604 38251 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
Binding affinity by competitive inhibition of the radioligand [3H]pCCK-8 at Cholecystokinin type B receptor from rat cerebral cortex membraneBinding affinity by competitive inhibition of the radioligand [3H]pCCK-8 at Cholecystokinin type B receptor from rat cerebral cortex membrane
ChEMBL 621 8 3 4 4.9 O=C(N[C@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@@H]12)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C12CC3CC(CC(C3)C1)C2 10.1021/jm991078x
CHEMBL140320 38251 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
Binding affinity by competitive inhibition of the radioligand [3H]pCCK-8 at Cholecystokinin type B receptor from rat cerebral cortex membraneBinding affinity by competitive inhibition of the radioligand [3H]pCCK-8 at Cholecystokinin type B receptor from rat cerebral cortex membrane
ChEMBL 621 8 3 4 4.9 O=C(N[C@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@@H]12)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C12CC3CC(CC(C3)C1)C2 10.1021/jm991078x
10392870 35873 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 552 7 2 5 5.4 O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)OCc2ccccc2)C1=O 10.1021/jm00078a018
CHEMBL138122 35873 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 552 7 2 5 5.4 O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)OCc2ccccc2)C1=O 10.1021/jm00078a018
9845465 125637 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 428 5 3 4 3.3 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CCO)C2=O)c1 10.1021/jm00078a018
CHEMBL342201 125637 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 428 5 3 4 3.3 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CCO)C2=O)c1 10.1021/jm00078a018
44280314 176473 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 694 12 4 5 6.2 O=C(CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O)Nc1cccc2ccccc12 10.1021/jm950372w
CHEMBL443781 176473 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 694 12 4 5 6.2 O=C(CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O)Nc1cccc2ccccc12 10.1021/jm950372w
14208272 74513 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 455 3 1 3 4.4 CN1C(=O)[C@@H](NC(=O)c2ccc(C(F)(F)F)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL1907841 74513 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 455 3 1 3 4.4 CN1C(=O)[C@@H](NC(=O)c2ccc(C(F)(F)F)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
44280495 105902 0 None - 0 Mouse 6.4 pIC50 = 6.4 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 641 10 5 8 3.7 CN1C(=O)[C@H](NC(=O)Nc2cccc(C(=O)NCCSCc3csc(N=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
CHEMBL280980 105902 0 None - 0 Mouse 6.4 pIC50 = 6.4 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 641 10 5 8 3.7 CN1C(=O)[C@H](NC(=O)Nc2cccc(C(=O)NCCSCc3csc(N=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
44334438 116032 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 513 9 2 4 5.2 Cc1cccc(NC(=O)N[C@@H](C(=O)N2CCC(C(=O)c3ccccc3)CC2)[C@@H](C)OCc2ccccc2)c1 10.1016/0960-894X(95)00537-3
CHEMBL321800 116032 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 513 9 2 4 5.2 Cc1cccc(NC(=O)N[C@@H](C(=O)N2CCC(C(=O)c3ccccc3)CC2)[C@@H](C)OCc2ccccc2)c1 10.1016/0960-894X(95)00537-3
14208308 74517 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 513 3 1 3 4.0 CN1C(=O)[C@H](NC(=O)c2ccccc2I)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL1907845 74517 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 513 3 1 3 4.0 CN1C(=O)[C@H](NC(=O)c2ccccc2I)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
14991544 113582 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 857 22 10 10 2.6 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCc1ccc(O)c(O)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL3144543 113582 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 857 22 10 10 2.6 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCc1ccc(O)c(O)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
90663991 113597 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 868 22 8 10 3.2 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc([N+](=O)[O-])cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL3144560 113597 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 868 22 8 10 3.2 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc([N+](=O)[O-])cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
44370406 56661 0 None - 0 Human 4.4 pIC50 = 4.4 Binding
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 529 16 2 4 6.6 CCCCCN(CCCCC)C(=O)C(CCC(=O)OCc1ccccc1)NC(=O)Nc1ccc(Cl)cc1 10.1021/jm00164a020
CHEMBL156814 56661 0 None - 0 Human 4.4 pIC50 = 4.4 Binding
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 529 16 2 4 6.6 CCCCCN(CCCCC)C(=O)C(CCC(=O)OCc1ccccc1)NC(=O)Nc1ccc(Cl)cc1 10.1021/jm00164a020
15719707 85262 0 None - 0 Rat 4.4 pIC50 = 4.4 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 368 8 3 3 2.9 CC(C)(C)CCNC(=O)[C@H](CCC(=O)O)NC(=O)c1cccc(Cl)c1 10.1021/jm00079a003
CHEMBL2111829 85262 0 None - 0 Rat 4.4 pIC50 = 4.4 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 368 8 3 3 2.9 CC(C)(C)CCNC(=O)[C@H](CCC(=O)O)NC(=O)c1cccc(Cl)c1 10.1021/jm00079a003
44280387 126546 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 559 8 3 4 5.4 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)Nc1ccccc1C(=O)O 10.1021/jm950372w
CHEMBL34797 126546 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 559 8 3 4 5.4 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)Nc1ccccc1C(=O)O 10.1021/jm950372w
10550527 214156 0 None - 0 Mouse 7.4 pIC50 = 7.4 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 429 6 3 6 4.2 CCOc1cccc(-n2c(NNC(=O)Nc3cccc(C)c3)nc3ccccc3c2=O)c1 10.1021/jm970373j
CHEMBL9377 214156 0 None - 0 Mouse 7.4 pIC50 = 7.4 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 429 6 3 6 4.2 CCOc1cccc(-n2c(NNC(=O)Nc3cccc(C)c3)nc3ccccc3c2=O)c1 10.1021/jm970373j
44280090 106312 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 640 11 4 4 5.7 O=C(O)CC(Cc1c[nH]c2ccccc12)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL283460 106312 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 640 11 4 4 5.7 O=C(O)CC(Cc1c[nH]c2ccccc12)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
44281205 121596 0 None - 1 Mouse 7.4 pIC50 = 7.4 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 857 17 4 10 5.1 CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCCN3CCN(C(=O)CNCCCOc4cccc(CN5CCCCC5)c4)CC3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
CHEMBL33412 121596 0 None - 1 Mouse 7.4 pIC50 = 7.4 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 857 17 4 10 5.1 CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCCN3CCN(C(=O)CNCCCOc4cccc(CN5CCCCC5)c4)CC3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
44280028 105953 0 None - 1 Human 7.4 pIC50 = 7.4 Binding
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 768 17 6 9 4.3 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCCCC(=O)NCCSCc3csc(N=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
CHEMBL281318 105953 0 None - 1 Human 7.4 pIC50 = 7.4 Binding
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 768 17 6 9 4.3 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCCCC(=O)NCCSCc3csc(N=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
44381852 65817 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
Inhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptorInhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptor
ChEMBL 723 20 7 8 3.2 CCCC[C@H](N[C@@H](C#N)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(=O)N[C@@H](Cc1ccccc1)C(N)=O)C(=O)O 10.1016/S0960-894X(97)00107-8
CHEMBL169398 65817 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
Inhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptorInhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptor
ChEMBL 723 20 7 8 3.2 CCCC[C@H](N[C@@H](C#N)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(=O)N[C@@H](Cc1ccccc1)C(N)=O)C(=O)O 10.1016/S0960-894X(97)00107-8
10601173 37967 0 None - 0 Mouse 7.3 pIC50 = 7.3 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 6 3 3 5.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1CCCCCC1 10.1021/jm970065l
CHEMBL140073 37967 0 None - 0 Mouse 7.3 pIC50 = 7.3 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 6 3 3 5.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1CCCCCC1 10.1021/jm970065l
10649606 56390 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]CCK from CCK2R (unknown origin) expressed in CHO cellsDisplacement of [125I]CCK from CCK2R (unknown origin) expressed in CHO cells
ChEMBL 519 6 3 4 4.5 O=C(CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)Nc1ccccc1 10.1016/j.bmcl.2015.03.051
CHEMBL156605 56390 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]CCK from CCK2R (unknown origin) expressed in CHO cellsDisplacement of [125I]CCK from CCK2R (unknown origin) expressed in CHO cells
ChEMBL 519 6 3 4 4.5 O=C(CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)Nc1ccccc1 10.1016/j.bmcl.2015.03.051
57390472 74529 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 431 5 1 4 3.3 COc1cccc(CC(=O)N[C@@H]2N=C(c3ccccc3F)c3ccccc3N(C)C2=O)c1 10.1021/jm00120a002
CHEMBL1907856 74529 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 431 5 1 4 3.3 COc1cccc(CC(=O)N[C@@H]2N=C(c3ccccc3F)c3ccccc3N(C)C2=O)c1 10.1021/jm00120a002
44329383 115068 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 526 6 3 3 5.5 Cc1cccc(NC(=O)N[C@H]2C[C@H](c3ccccc3)C[C@H](c3ccccc3)N(CC(=O)NC(C)(C)C)C2=O)c1 10.1016/S0960-894X(01)80832-5
CHEMBL319749 115068 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 526 6 3 3 5.5 Cc1cccc(NC(=O)N[C@H]2C[C@H](c3ccccc3)C[C@H](c3ccccc3)N(CC(=O)NC(C)(C)C)C2=O)c1 10.1016/S0960-894X(01)80832-5
CHEMBL107694 215269 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL None None None Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
CHEMBL156559 215584 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL None None None Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00173a006
44381480 66229 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptorDisplacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptor
ChEMBL 825 20 7 8 4.6 Cc1ccccc1NC(=O)NCCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1016/S0960-894X(00)80680-0
CHEMBL171227 66229 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptorDisplacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptor
ChEMBL 825 20 7 8 4.6 Cc1ccccc1NC(=O)NCCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1016/S0960-894X(00)80680-0
CHEMBL156559 215584 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
In vitro ability to inhibit [125I]Bolton-Hunter-CCK-8 binding to Cholecystokinin type B receptor in guinea pig cortexIn vitro ability to inhibit [125I]Bolton-Hunter-CCK-8 binding to Cholecystokinin type B receptor in guinea pig cortex
ChEMBL None None None Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00031a013
44375073 61713 0 None - 0 Mouse 5.4 pIC50 = 5.4 Binding
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 554 10 6 7 4.0 O=C(O)c1ccccc1NS(=O)(=O)c1ccc(N/N=C(/S)NCCc2c[nH]c3ccccc23)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
CHEMBL161426 61713 0 None - 0 Mouse 5.4 pIC50 = 5.4 Binding
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 554 10 6 7 4.0 O=C(O)c1ccccc1NS(=O)(=O)c1ccc(N/N=C(/S)NCCc2c[nH]c3ccccc23)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
44370446 126379 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 467 15 2 4 5.4 CCCCCN(CCCCC)C(=O)C(CCC(=O)OCC)NC(=O)Nc1ccc(Cl)cc1 10.1021/jm00164a020
CHEMBL346361 126379 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 467 15 2 4 5.4 CCCCCN(CCCCC)C(=O)C(CCC(=O)OCC)NC(=O)Nc1ccc(Cl)cc1 10.1021/jm00164a020
CHEMBL156559 215584 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL None None None Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
44303510 18805 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Compound was tested for its binding affinity towards Cholecystokinin type B receptor in cortical membranes (CNS)Compound was tested for its binding affinity towards Cholecystokinin type B receptor in cortical membranes (CNS)
ChEMBL 617 17 6 9 1.5 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)[C@@H](Cc1ccccc1)C(N)=O)n1nnnc1[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN 10.1016/S0960-894X(01)81005-2
CHEMBL1183386 18805 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Compound was tested for its binding affinity towards Cholecystokinin type B receptor in cortical membranes (CNS)Compound was tested for its binding affinity towards Cholecystokinin type B receptor in cortical membranes (CNS)
ChEMBL 617 17 6 9 1.5 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)[C@@H](Cc1ccccc1)C(N)=O)n1nnnc1[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN 10.1016/S0960-894X(01)81005-2
CHEMBL294329 18805 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Compound was tested for its binding affinity towards Cholecystokinin type B receptor in cortical membranes (CNS)Compound was tested for its binding affinity towards Cholecystokinin type B receptor in cortical membranes (CNS)
ChEMBL 617 17 6 9 1.5 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)[C@@H](Cc1ccccc1)C(N)=O)n1nnnc1[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN 10.1016/S0960-894X(01)81005-2
44329305 116002 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 610 7 3 3 7.5 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)NC(C(C)(C)C)C(C)(C)C)C2=O)c1 10.1016/S0960-894X(01)80832-5
CHEMBL321752 116002 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 610 7 3 3 7.5 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)NC(C(C)(C)C)C(C)(C)C)C2=O)c1 10.1016/S0960-894X(01)80832-5
155540394 179715 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1820 69 17 23 2.7 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4516794 179715 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1820 69 17 23 2.7 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
155566319 182519 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1850 71 16 23 3.2 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4583158 182519 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1850 71 16 23 3.2 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
14843041 131820 0 None - 0 Mouse 7.3 pIC50 = 7.3 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 471 5 1 3 6.0 CCc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
CHEMBL36436 131820 0 None - 0 Mouse 7.3 pIC50 = 7.3 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 471 5 1 3 6.0 CCc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
14843043 136922 0 None - 0 Mouse 7.3 pIC50 = 7.3 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 489 5 1 4 6.1 CSc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
CHEMBL36779 136922 0 None - 0 Mouse 7.3 pIC50 = 7.3 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 489 5 1 4 6.1 CSc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
44356645 32547 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 419 3 2 4 3.7 CN1C(=O)C(NC(=O)Nc2ccc(Cl)nc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL135290 32547 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 419 3 2 4 3.7 CN1C(=O)C(NC(=O)Nc2ccc(Cl)nc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
10455302 34772 2 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 429 4 2 5 3.6 CN1C(=O)C(NC(=O)Nc2ccc([N+](=O)[O-])cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL137240 34772 2 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 429 4 2 5 3.6 CN1C(=O)C(NC(=O)Nc2ccc([N+](=O)[O-])cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
44280501 106799 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 698 12 4 5 5.6 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NC1CCCc2ccccc21 10.1021/jm950372w
CHEMBL286847 106799 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 698 12 4 5 5.6 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NC1CCCc2ccccc21 10.1021/jm950372w
19766160 65283 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 456 4 2 3 3.9 O=C(Nc1cccc2ccccc12)NC1CCc2ccccc2N(CC(=O)N2CCCC2)C1=O 10.1016/S0960-894X(00)80683-6
CHEMBL168386 65283 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 456 4 2 3 3.9 O=C(Nc1cccc2ccccc12)NC1CCc2ccccc2N(CC(=O)N2CCCC2)C1=O 10.1016/S0960-894X(00)80683-6
44356619 125574 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 415 4 2 5 3.1 COc1ccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cn1 10.1021/jm00078a018
CHEMBL342142 125574 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 415 4 2 5 3.1 COc1ccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cn1 10.1021/jm00078a018
44281004 106855 0 None - 1 Mouse 6.3 pIC50 = 6.3 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 773 15 4 8 6.4 Cc1cccc(NC(=O)N[C@@H]2N=C(c3cccc(OC(=O)NCCCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00249-1
CHEMBL287295 106855 0 None - 1 Mouse 6.3 pIC50 = 6.3 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 773 15 4 8 6.4 Cc1cccc(NC(=O)N[C@@H]2N=C(c3cccc(OC(=O)NCCCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00249-1
10373344 173413 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL 844 21 8 7 3.8 Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
CHEMBL428103 173413 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL 844 21 8 7 3.8 Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
10476766 109777 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 412 3 3 3 3.9 O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1cc2ccccc2[nH]1 10.1021/jm00120a002
CHEMBL306806 109777 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 412 3 3 3 3.9 O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1cc2ccccc2[nH]1 10.1021/jm00120a002
14208312 84597 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 437 3 1 3 4.3 CN1C(=O)[C@@H](NC(=O)c2ccc(C(F)(F)F)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL2092865 84597 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 437 3 1 3 4.3 CN1C(=O)[C@@H](NC(=O)c2ccc(C(F)(F)F)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
44375711 60217 0 None - 0 Mouse 4.3 pIC50 = 4.3 Binding
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 492 10 6 7 1.9 O=C(O)CNS(=O)(=O)c1ccc(N/N=C(/S)NCCc2c[nH]c3ccccc23)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
CHEMBL160092 60217 0 None - 0 Mouse 4.3 pIC50 = 4.3 Binding
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 492 10 6 7 1.9 O=C(O)CNS(=O)(=O)c1ccc(N/N=C(/S)NCCc2c[nH]c3ccccc23)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
14843037 145401 0 None - 0 Mouse 7.3 pIC50 = 7.3 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 429 5 1 4 5.3 COc1cccc(-n2c(CCc3c[nH]c4ccc(Cl)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
CHEMBL37758 145401 0 None - 0 Mouse 7.3 pIC50 = 7.3 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 429 5 1 4 5.3 COc1cccc(-n2c(CCc3c[nH]c4ccc(Cl)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
90663995 113601 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 919 23 9 11 2.4 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(OS(=O)(=O)O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL3144564 113601 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 919 23 9 11 2.4 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(OS(=O)(=O)O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
10033396 115366 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL 824 20 8 7 3.5 Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
CHEMBL320405 115366 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL 824 20 8 7 3.5 Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
CHEMBL156559 215584 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL None None None Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
14991579 107767 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 862 21 9 8 3.7 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C/c1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL294304 107767 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 862 21 9 8 3.7 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C/c1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
10555164 119531 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 575 7 1 4 6.0 CC(C)N(C(=O)CN1C(=O)C(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc21)c1ccc(F)cc1 10.1021/jm970265x
CHEMBL330521 119531 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 575 7 1 4 6.0 CC(C)N(C(=O)CN1C(=O)C(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc21)c1ccc(F)cc1 10.1021/jm970265x
44369350 126851 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligandBinding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligand
ChEMBL 495 6 2 5 4.5 Cc1cccc(NC(=O)NC2N=C(c3ccncc3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1016/0960-894X(95)00557-A
CHEMBL350683 126851 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligandBinding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligand
ChEMBL 495 6 2 5 4.5 Cc1cccc(NC(=O)NC2N=C(c3ccncc3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1016/0960-894X(95)00557-A
10323690 107274 0 None - 2 Mouse 7.3 pIC50 = 7.3 Binding
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 499 8 3 3 5.4 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccc1 10.1021/jm00105a062
CHEMBL2114401 107274 0 None - 2 Mouse 7.3 pIC50 = 7.3 Binding
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 499 8 3 3 5.4 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccc1 10.1021/jm00105a062
CHEMBL291033 107274 0 None - 2 Mouse 7.3 pIC50 = 7.3 Binding
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 499 8 3 3 5.4 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccc1 10.1021/jm00105a062
10102593 148283 2 None - 0 Rat 7.3 pIC50 = 7.3 Binding
In vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic aciniIn vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic acini
ChEMBL 1048 29 10 12 3.3 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 10.1016/S0960-894X(00)80679-4
CHEMBL384505 148283 2 None - 0 Rat 7.3 pIC50 = 7.3 Binding
In vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic aciniIn vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic acini
ChEMBL 1048 29 10 12 3.3 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 10.1016/S0960-894X(00)80679-4
10413618 209570 0 None - 1 Mouse 7.3 pIC50 = 7.3 Binding
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 499 8 3 3 5.4 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 10.1016/S0960-894X(01)80769-1
CHEMBL62205 209570 0 None - 1 Mouse 7.3 pIC50 = 7.3 Binding
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 499 8 3 3 5.4 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 10.1016/S0960-894X(01)80769-1
10073082 31909 2 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 462 3 2 3 4.4 CN1C(=O)C(NC(=O)Nc2ccc(Br)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL134750 31909 2 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 462 3 2 3 4.4 CN1C(=O)C(NC(=O)Nc2ccc(Br)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
10075297 122284 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 518 6 3 5 4.4 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)Nc3ccncc3)C2=O)c1 10.1021/jm00078a018
CHEMBL335239 122284 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 518 6 3 5 4.4 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)Nc3ccncc3)C2=O)c1 10.1021/jm00078a018
10323690 107274 0 None - 2 Mouse 7.3 pIC50 = 7.3 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 499 8 3 3 5.4 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccc1 10.1021/jm00057a005
CHEMBL2114401 107274 0 None - 2 Mouse 7.3 pIC50 = 7.3 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 499 8 3 3 5.4 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccc1 10.1021/jm00057a005
CHEMBL291033 107274 0 None - 2 Mouse 7.3 pIC50 = 7.3 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 499 8 3 3 5.4 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccc1 10.1021/jm00057a005
10413618 209570 0 None - 1 Mouse 7.3 pIC50 = 7.3 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 499 8 3 3 5.4 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 10.1021/jm970065l
CHEMBL62205 209570 0 None - 1 Mouse 7.3 pIC50 = 7.3 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 499 8 3 3 5.4 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 10.1021/jm970065l
44336539 11916 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]CCK from CCK2R (unknown origin) expressed in CHO cellsDisplacement of [125I]CCK from CCK2R (unknown origin) expressed in CHO cells
ChEMBL 563 7 2 5 4.6 COc1ccc(N(C)C(=O)CN2C(=O)C(NC(=O)Nc3ccccc3)C(=O)N(c3ccccc3)c3ccccc32)cc1 10.1016/j.bmcl.2015.03.051
CHEMBL105775 11916 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]CCK from CCK2R (unknown origin) expressed in CHO cellsDisplacement of [125I]CCK from CCK2R (unknown origin) expressed in CHO cells
ChEMBL 563 7 2 5 4.6 COc1ccc(N(C)C(=O)CN2C(=O)C(NC(=O)Nc3ccccc3)C(=O)N(c3ccccc3)c3ccccc32)cc1 10.1016/j.bmcl.2015.03.051
44210427 127546 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 459 4 2 4 4.7 CC(C)(C)OC(=O)CN1C(=O)C(NC(=O)Nc2cccc3ccccc23)CCc2ccccc21 10.1016/S0960-894X(00)80683-6
CHEMBL355319 127546 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 459 4 2 4 4.7 CC(C)(C)OC(=O)CN1C(=O)C(NC(=O)Nc2cccc3ccccc23)CCc2ccccc21 10.1016/S0960-894X(00)80683-6
14843033 143733 0 None - 0 Mouse 6.3 pIC50 = 6.3 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 433 4 1 3 5.7 O=c1c2ccccc2nc(CCc2c[nH]c3ccccc23)n1-c1cccc(C(F)(F)F)c1 10.1021/jm00108a040
CHEMBL37439 143733 0 None - 0 Mouse 6.3 pIC50 = 6.3 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 433 4 1 3 5.7 O=c1c2ccccc2nc(CCc2c[nH]c3ccccc23)n1-c1cccc(C(F)(F)F)c1 10.1021/jm00108a040
14991564 113580 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 827 21 9 9 2.5 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL3144541 113580 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 827 21 9 9 2.5 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
44280180 109410 0 None - 0 Mouse 6.3 pIC50 = 6.3 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 655 11 5 8 3.6 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCSCc3csc(N=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
CHEMBL30430 109410 0 None - 0 Mouse 6.3 pIC50 = 6.3 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 655 11 5 8 3.6 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCSCc3csc(N=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
10010890 115514 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL 874 22 8 8 4.3 Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
CHEMBL320858 115514 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL 874 22 8 8 4.3 Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
CHEMBL319439 217997 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL None None None CNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
44458049 105873 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Displacement of [125I]CCK-OP radioligand from Cholecystokinin type B receptor of guinea pig cortical membranesDisplacement of [125I]CCK-OP radioligand from Cholecystokinin type B receptor of guinea pig cortical membranes
ChEMBL 363 4 3 3 2.0 O=C(N[C@@H]1C(=O)N(c2ccccc2)C[C@@H]1C(=O)O)c1cc2ccccc2[nH]1 10.1016/S0960-894X(00)80224-3
CHEMBL280733 105873 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Displacement of [125I]CCK-OP radioligand from Cholecystokinin type B receptor of guinea pig cortical membranesDisplacement of [125I]CCK-OP radioligand from Cholecystokinin type B receptor of guinea pig cortical membranes
ChEMBL 363 4 3 3 2.0 O=C(N[C@@H]1C(=O)N(c2ccccc2)C[C@@H]1C(=O)O)c1cc2ccccc2[nH]1 10.1016/S0960-894X(00)80224-3
13953709 169117 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Displacement of [125I]gastrin from guinea pig gastric glandsDisplacement of [125I]gastrin from guinea pig gastric glands
ChEMBL 409 4 1 6 4.0 O=C(NC1N=C(c2ccccc2)c2ccccc2-n2cnnc21)OCc1ccccc1 10.1021/jm00396a028
CHEMBL416483 169117 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Displacement of [125I]gastrin from guinea pig gastric glandsDisplacement of [125I]gastrin from guinea pig gastric glands
ChEMBL 409 4 1 6 4.0 O=C(NC1N=C(c2ccccc2)c2ccccc2-n2cnnc21)OCc1ccccc1 10.1021/jm00396a028
14991538 113603 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 921 24 9 11 2.4 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL3144566 113603 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 921 24 9 11 2.4 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
44334259 11244 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 435 8 2 3 4.8 CCCC[C@@H](NC(=O)Nc1cccc(C)c1)C(=O)N1CCC(C(=O)c2ccccc2)CC1 10.1016/0960-894X(95)00537-3
CHEMBL101803 11244 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 435 8 2 3 4.8 CCCC[C@@H](NC(=O)Nc1cccc(C)c1)C(=O)N1CCC(C(=O)c2ccccc2)CC1 10.1016/0960-894X(95)00537-3
44349327 23669 0 None - 0 Rat 4.3 pIC50 = 4.3 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 334 8 3 3 2.2 CC(C)(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1ccccc1 10.1021/jm00079a003
CHEMBL125083 23669 0 None - 0 Rat 4.3 pIC50 = 4.3 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 334 8 3 3 2.2 CC(C)(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1ccccc1 10.1021/jm00079a003
155564421 182047 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1770 69 16 21 3.7 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4572516 182047 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1770 69 16 21 3.7 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
44368368 127855 0 None - 0 Mouse 7.3 pIC50 = 7.3 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 481 8 3 3 5.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1CCCCC1Cl)C(=O)NCCc1ccccc1 10.1021/jm00057a005
CHEMBL357027 127855 0 None - 0 Mouse 7.3 pIC50 = 7.3 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 481 8 3 3 5.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1CCCCC1Cl)C(=O)NCCc1ccccc1 10.1021/jm00057a005
44212546 106704 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 626 10 4 4 5.3 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm950372w
CHEMBL286228 106704 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 626 10 4 4 5.3 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm950372w
44280407 126489 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 658 12 3 5 4.7 CN(Cc1ccccc1)C(=O)[C@@H](CC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL34743 126489 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 658 12 3 5 4.7 CN(Cc1ccccc1)C(=O)[C@@H](CC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
9870046 33120 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 486 5 3 6 3.4 O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(Cc2nn[nH]n2)C1=O 10.1021/jm00078a018
CHEMBL135901 33120 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 486 5 3 6 3.4 O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(Cc2nn[nH]n2)C1=O 10.1021/jm00078a018
CHEMBL99786 222708 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Displacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL None None None CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00173a006
10603571 175299 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
In vitro inhibition of [3H]propionyl-CCK-8 binding to rat cerebral cortex membranes at Cholecystokinin type B receptor.In vitro inhibition of [3H]propionyl-CCK-8 binding to rat cerebral cortex membranes at Cholecystokinin type B receptor.
ChEMBL 594 9 3 6 4.0 COC(=O)C[C@@H](Cc1ccccc1)NC(=O)[C@H]1Cc2c([nH]c3ccccc23)[C@@H]2C[C@@H](NC(=O)OCc3ccccc3)C(=O)N21 10.1021/jm000959x
CHEMBL435407 175299 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
In vitro inhibition of [3H]propionyl-CCK-8 binding to rat cerebral cortex membranes at Cholecystokinin type B receptor.In vitro inhibition of [3H]propionyl-CCK-8 binding to rat cerebral cortex membranes at Cholecystokinin type B receptor.
ChEMBL 594 9 3 6 4.0 COC(=O)C[C@@H](Cc1ccccc1)NC(=O)[C@H]1Cc2c([nH]c3ccccc23)[C@@H]2C[C@@H](NC(=O)OCc3ccccc3)C(=O)N21 10.1021/jm000959x
10838675 213992 0 None - 0 Mouse 8.3 pIC50 = 8.3 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 487 8 3 8 4.1 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(OCC)c2)c1 10.1021/jm970373j
CHEMBL9267 213992 0 None - 0 Mouse 8.3 pIC50 = 8.3 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 487 8 3 8 4.1 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(OCC)c2)c1 10.1021/jm970373j
10719721 214209 0 None - 0 Mouse 8.3 pIC50 = 8.3 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 486 7 3 8 3.8 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(N(C)C)c2)c1 10.1021/jm970373j
CHEMBL9406 214209 0 None - 0 Mouse 8.3 pIC50 = 8.3 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 486 7 3 8 3.8 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(N(C)C)c2)c1 10.1021/jm970373j
14888738 105130 0 None - 0 Bovine 8.3 pIC50 = 8.3 Binding
Inhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranesInhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranes
ChEMBL 984 28 10 13 0.8 CSCC[C@H](NC(=O)CCc1ccc(-c2nn[nH]n2)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00107a037
CHEMBL275167 105130 0 None - 0 Bovine 8.3 pIC50 = 8.3 Binding
Inhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranesInhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranes
ChEMBL 984 28 10 13 0.8 CSCC[C@H](NC(=O)CCc1ccc(-c2nn[nH]n2)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00107a037
44348902 162541 0 None - 0 Bovine 8.3 pIC50 = 8.3 Binding
Inhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatumInhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatum
ChEMBL 1000 24 11 11 2.3 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1cc(NC(=O)[C@H](Cc2ccc(S(=O)(=O)O)cc2)NC(=O)O)ccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00099a005
CHEMBL405805 162541 0 None - 0 Bovine 8.3 pIC50 = 8.3 Binding
Inhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatumInhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatum
ChEMBL 1000 24 11 11 2.3 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1cc(NC(=O)[C@H](Cc2ccc(S(=O)(=O)O)cc2)NC(=O)O)ccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00099a005
10389657 31430 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 462 3 2 3 4.4 CN1C(=O)C(NC(=O)Nc2cccc(Br)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL134340 31430 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 462 3 2 3 4.4 CN1C(=O)C(NC(=O)Nc2cccc(Br)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
9987406 103143 0 None - 0 Mouse 8.3 pIC50 = 8.3 Binding
Evaluated for Cholecystokinin type B receptor antagonistic activity in which 20 pM [125I]BH-CCK-8S was used to label CCKB/gastrin binding sites in mouse cortical homogenatesEvaluated for Cholecystokinin type B receptor antagonistic activity in which 20 pM [125I]BH-CCK-8S was used to label CCKB/gastrin binding sites in mouse cortical homogenates
ChEMBL 717 8 5 6 5.9 O=C(O)c1cc(NC(=O)C2Cc3ccccc3CCCCN2C(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1016/S0960-894X(97)00211-4
CHEMBL26167 103143 0 None - 0 Mouse 8.3 pIC50 = 8.3 Binding
Evaluated for Cholecystokinin type B receptor antagonistic activity in which 20 pM [125I]BH-CCK-8S was used to label CCKB/gastrin binding sites in mouse cortical homogenatesEvaluated for Cholecystokinin type B receptor antagonistic activity in which 20 pM [125I]BH-CCK-8S was used to label CCKB/gastrin binding sites in mouse cortical homogenates
ChEMBL 717 8 5 6 5.9 O=C(O)c1cc(NC(=O)C2Cc3ccccc3CCCCN2C(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1016/S0960-894X(97)00211-4
44301016 164755 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 673 7 4 6 4.5 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)NS(=O)(=O)C(F)(F)F)c1)C[C@@H]2c1ccccc1 10.1016/0960-894X(95)00327-P
CHEMBL408490 164755 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 673 7 4 6 4.5 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)NS(=O)(=O)C(F)(F)F)c1)C[C@@H]2c1ccccc1 10.1016/0960-894X(95)00327-P
5311201 214174 35 None -26 6 Mouse 8.3 pIC50 = 8.3 Binding
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00092a007
CHEMBL9387 214174 35 None -26 6 Mouse 8.3 pIC50 = 8.3 Binding
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00092a007
5311201 214174 35 None -26 6 Mouse 8.3 pIC50 = 8.3 Binding
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00105a062
CHEMBL9387 214174 35 None -26 6 Mouse 8.3 pIC50 = 8.3 Binding
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00105a062
5311201 214174 35 None -26 6 Mouse 8.3 pIC50 = 8.3 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00057a005
CHEMBL9387 214174 35 None -26 6 Mouse 8.3 pIC50 = 8.3 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00057a005
CHEMBL2386885 217176 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of Eu-DTPA-CCK8 from CCK2 receptor in HEK293 cells after 2 hrs by TRF assayDisplacement of Eu-DTPA-CCK8 from CCK2 receptor in HEK293 cells after 2 hrs by TRF assay
ChEMBL None None None C#CCCC(=O)NCCCC[C@H](NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1cn(CC(=O)NCCC(=O)NCCCC(CCCNC(=O)CCNC(=O)Cn2cc(NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCC)N(C)C(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCCNC(=O)CCC#C)NC(C)=O)nn2)(NC(=O)CNC(=O)CCNC(=O)Cn2cc(NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCC)N(C)C(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCCNC(=O)CCC#C)NC(C)=O)nn2)C(=O)NCCC(N)=O)nn1 10.1016/j.bmcl.2013.02.022
104929 9000 9 None 51 3 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-gastrin17 from CCK-B receptor (unknown origin)Displacement of [125I]-gastrin17 from CCK-B receptor (unknown origin)
ChEMBL 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 10.1039/C7MD00171A
3477 9000 9 None 51 3 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-gastrin17 from CCK-B receptor (unknown origin)Displacement of [125I]-gastrin17 from CCK-B receptor (unknown origin)
ChEMBL 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 10.1039/C7MD00171A
879 9000 9 None 51 3 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-gastrin17 from CCK-B receptor (unknown origin)Displacement of [125I]-gastrin17 from CCK-B receptor (unknown origin)
ChEMBL 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 10.1039/C7MD00171A
CHEMBL289498 9000 9 None 51 3 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-gastrin17 from CCK-B receptor (unknown origin)Displacement of [125I]-gastrin17 from CCK-B receptor (unknown origin)
ChEMBL 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 10.1039/C7MD00171A
10770670 99268 0 None 301 2 Mouse 8.3 pIC50 = 8.3 Binding
Evaluated for Cholecystokinin type B receptor antagonistic activity in which 20 pM [125I]BH-CCK-8S was used to label CCKB/gastrin binding sites in mouse cortical homogenatesEvaluated for Cholecystokinin type B receptor antagonistic activity in which 20 pM [125I]BH-CCK-8S was used to label CCKB/gastrin binding sites in mouse cortical homogenates
ChEMBL 663 11 6 6 4.9 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1016/S0960-894X(97)00211-4
CHEMBL2067959 99268 0 None 301 2 Mouse 8.3 pIC50 = 8.3 Binding
Evaluated for Cholecystokinin type B receptor antagonistic activity in which 20 pM [125I]BH-CCK-8S was used to label CCKB/gastrin binding sites in mouse cortical homogenatesEvaluated for Cholecystokinin type B receptor antagonistic activity in which 20 pM [125I]BH-CCK-8S was used to label CCKB/gastrin binding sites in mouse cortical homogenates
ChEMBL 663 11 6 6 4.9 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1016/S0960-894X(97)00211-4
CHEMBL24313 99268 0 None 301 2 Mouse 8.3 pIC50 = 8.3 Binding
Evaluated for Cholecystokinin type B receptor antagonistic activity in which 20 pM [125I]BH-CCK-8S was used to label CCKB/gastrin binding sites in mouse cortical homogenatesEvaluated for Cholecystokinin type B receptor antagonistic activity in which 20 pM [125I]BH-CCK-8S was used to label CCKB/gastrin binding sites in mouse cortical homogenates
ChEMBL 663 11 6 6 4.9 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1016/S0960-894X(97)00211-4
5311201 214174 35 None -27 6 Human 8.3 pIC50 = 8.3 Binding
Inhibition of [125I]-labeled CCK-8 sulfate binding to CCK-B receptor in guinea pig brain membranesInhibition of [125I]-labeled CCK-8 sulfate binding to CCK-B receptor in guinea pig brain membranes
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00108a040
CHEMBL9387 214174 35 None -27 6 Human 8.3 pIC50 = 8.3 Binding
Inhibition of [125I]-labeled CCK-8 sulfate binding to CCK-B receptor in guinea pig brain membranesInhibition of [125I]-labeled CCK-8 sulfate binding to CCK-B receptor in guinea pig brain membranes
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00108a040
10319892 65865 2 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 418 3 2 3 4.3 CN1C(=O)[C@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00121a004
CHEMBL169661 65865 2 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 418 3 2 3 4.3 CN1C(=O)[C@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00121a004
10319892 65865 2 None - 0 Human 8.3 pIC50 = 8.3 Binding
Tested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brainTested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL 418 3 2 3 4.3 CN1C(=O)[C@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80682-4
CHEMBL169661 65865 2 None - 0 Human 8.3 pIC50 = 8.3 Binding
Tested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brainTested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL 418 3 2 3 4.3 CN1C(=O)[C@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80682-4
4627 7609 50 None 1 5 Rat 8.3 pIC50 = 8.3 Binding
Binding affinity by competitive inhibition of the radioligand [3H]pCCK-8 at Cholecystokinin type B receptor from rat cerebral cortex membraneBinding affinity by competitive inhibition of the radioligand [3H]pCCK-8 at Cholecystokinin type B receptor from rat cerebral cortex membrane
ChEMBL None None None None 10.1021/jm991078x
864 7609 50 None 1 5 Rat 8.3 pIC50 = 8.3 Binding
Binding affinity by competitive inhibition of the radioligand [3H]pCCK-8 at Cholecystokinin type B receptor from rat cerebral cortex membraneBinding affinity by competitive inhibition of the radioligand [3H]pCCK-8 at Cholecystokinin type B receptor from rat cerebral cortex membrane
ChEMBL None None None None 10.1021/jm991078x
9833444 7609 50 None 1 5 Rat 8.3 pIC50 = 8.3 Binding
Binding affinity by competitive inhibition of the radioligand [3H]pCCK-8 at Cholecystokinin type B receptor from rat cerebral cortex membraneBinding affinity by competitive inhibition of the radioligand [3H]pCCK-8 at Cholecystokinin type B receptor from rat cerebral cortex membrane
ChEMBL None None None None 10.1021/jm991078x
CHEMBL1121 7609 50 None 1 5 Rat 8.3 pIC50 = 8.3 Binding
Binding affinity by competitive inhibition of the radioligand [3H]pCCK-8 at Cholecystokinin type B receptor from rat cerebral cortex membraneBinding affinity by competitive inhibition of the radioligand [3H]pCCK-8 at Cholecystokinin type B receptor from rat cerebral cortex membrane
ChEMBL None None None None 10.1021/jm991078x
DB09142 7609 50 None 1 5 Rat 8.3 pIC50 = 8.3 Binding
Binding affinity by competitive inhibition of the radioligand [3H]pCCK-8 at Cholecystokinin type B receptor from rat cerebral cortex membraneBinding affinity by competitive inhibition of the radioligand [3H]pCCK-8 at Cholecystokinin type B receptor from rat cerebral cortex membrane
ChEMBL None None None None 10.1021/jm991078x
51353551 24906 16 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]CCK from CCK2R (unknown origin) expressed in CHO cellsDisplacement of [125I]CCK from CCK2R (unknown origin) expressed in CHO cells
ChEMBL 605 8 3 5 5.0 CC(C)N(C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(C(=O)O)c2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1016/j.bmcl.2015.03.051
CHEMBL1269257 24906 16 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]CCK from CCK2R (unknown origin) expressed in CHO cellsDisplacement of [125I]CCK from CCK2R (unknown origin) expressed in CHO cells
ChEMBL 605 8 3 5 5.0 CC(C)N(C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(C(=O)O)c2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1016/j.bmcl.2015.03.051
4627 7609 50 None 1 5 Rat 8.3 pIC50 = 8.3 Binding
Inhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenatesInhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenates
ChEMBL None None None None 10.1021/jm0498755
864 7609 50 None 1 5 Rat 8.3 pIC50 = 8.3 Binding
Inhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenatesInhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenates
ChEMBL None None None None 10.1021/jm0498755
9833444 7609 50 None 1 5 Rat 8.3 pIC50 = 8.3 Binding
Inhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenatesInhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenates
ChEMBL None None None None 10.1021/jm0498755
CHEMBL1121 7609 50 None 1 5 Rat 8.3 pIC50 = 8.3 Binding
Inhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenatesInhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenates
ChEMBL None None None None 10.1021/jm0498755
DB09142 7609 50 None 1 5 Rat 8.3 pIC50 = 8.3 Binding
Inhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenatesInhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenates
ChEMBL None None None None 10.1021/jm0498755
4627 7609 50 None 1 5 Rat 8.3 pIC50 = 8.3 Binding
Inhibition of [3H]pCCK-8 binding to cholecystokinin type B receptor of rat cerebral cortexInhibition of [3H]pCCK-8 binding to cholecystokinin type B receptor of rat cerebral cortex
ChEMBL None None None None 10.1021/jm010898i
864 7609 50 None 1 5 Rat 8.3 pIC50 = 8.3 Binding
Inhibition of [3H]pCCK-8 binding to cholecystokinin type B receptor of rat cerebral cortexInhibition of [3H]pCCK-8 binding to cholecystokinin type B receptor of rat cerebral cortex
ChEMBL None None None None 10.1021/jm010898i
9833444 7609 50 None 1 5 Rat 8.3 pIC50 = 8.3 Binding
Inhibition of [3H]pCCK-8 binding to cholecystokinin type B receptor of rat cerebral cortexInhibition of [3H]pCCK-8 binding to cholecystokinin type B receptor of rat cerebral cortex
ChEMBL None None None None 10.1021/jm010898i
CHEMBL1121 7609 50 None 1 5 Rat 8.3 pIC50 = 8.3 Binding
Inhibition of [3H]pCCK-8 binding to cholecystokinin type B receptor of rat cerebral cortexInhibition of [3H]pCCK-8 binding to cholecystokinin type B receptor of rat cerebral cortex
ChEMBL None None None None 10.1021/jm010898i
DB09142 7609 50 None 1 5 Rat 8.3 pIC50 = 8.3 Binding
Inhibition of [3H]pCCK-8 binding to cholecystokinin type B receptor of rat cerebral cortexInhibition of [3H]pCCK-8 binding to cholecystokinin type B receptor of rat cerebral cortex
ChEMBL None None None None 10.1021/jm010898i
444998 216098 30 None - 0 Rat 8.3 pIC50 = 8.3 Binding
Inhibition of [3H]pCCK-8 specific binding cholecystokinin type B receptor in rat cerebral cortex membranesInhibition of [3H]pCCK-8 specific binding cholecystokinin type B receptor in rat cerebral cortex membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm010813d
CHEMBL216166 216098 30 None - 0 Rat 8.3 pIC50 = 8.3 Binding
Inhibition of [3H]pCCK-8 specific binding cholecystokinin type B receptor in rat cerebral cortex membranesInhibition of [3H]pCCK-8 specific binding cholecystokinin type B receptor in rat cerebral cortex membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm010813d
11757086 32448 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 541 10 2 6 4.2 CCN(CC)CC(=O)OCCN1C(=O)C(NC(=O)Nc2cccc(C)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL135218 32448 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 541 10 2 6 4.2 CCN(CC)CC(=O)OCCN1C(=O)C(NC(=O)Nc2cccc(C)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
9960964 92768 0 None - 0 Mouse 8.3 pIC50 = 8.3 Binding
The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the mouse cerebral cortex (CCK-B);value ranges from 3.0 to 8.1The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the mouse cerebral cortex (CCK-B);value ranges from 3.0 to 8.1
ChEMBL 638 12 5 7 4.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCc1nnn[nH]1)c1ccccc1 10.1016/S0960-894X(00)80652-6
CHEMBL2304152 92768 0 None - 0 Mouse 8.3 pIC50 = 8.3 Binding
The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the mouse cerebral cortex (CCK-B);value ranges from 3.0 to 8.1The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the mouse cerebral cortex (CCK-B);value ranges from 3.0 to 8.1
ChEMBL 638 12 5 7 4.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCc1nnn[nH]1)c1ccccc1 10.1016/S0960-894X(00)80652-6
10341247 126868 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.
ChEMBL 405 2 2 4 3.4 Cc1cccc(NC(=O)NC2N=C(N3CCCCC3)c3ccccc3N(C)C2=O)c1 10.1021/jm00032a002
CHEMBL350853 126868 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.
ChEMBL 405 2 2 4 3.4 Cc1cccc(NC(=O)NC2N=C(N3CCCCC3)c3ccccc3N(C)C2=O)c1 10.1021/jm00032a002
10695559 65811 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesInhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranes
ChEMBL 467 5 4 7 2.9 CN1C(=O)[C@H](NC(=O)Nc2cccc(Nc3nn[nH]n3)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm9506736
CHEMBL169362 65811 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesInhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranes
ChEMBL 467 5 4 7 2.9 CN1C(=O)[C@H](NC(=O)Nc2cccc(Nc3nn[nH]n3)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm9506736
44356799 32836 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 452 3 2 3 4.7 CN1C(=O)C(NC(=O)Nc2ccc(C(F)(F)F)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL135538 32836 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 452 3 2 3 4.7 CN1C(=O)C(NC(=O)Nc2ccc(C(F)(F)F)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
155557285 181297 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1779 74 19 22 1.6 CCCC[C@H](NC(=O)[C@H](CNC(=O)CCCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4555341 181297 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1779 74 19 22 1.6 CCCC[C@H](NC(=O)[C@H](CNC(=O)CCCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
10789229 105156 0 None - 0 Mouse 8.2 pIC50 = 8.2 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 440 6 3 7 3.8 CCOc1cccc(-n2c(NNC(=O)Nc3cccc(C#N)c3)nc3ccccc3c2=O)c1 10.1021/jm970373j
CHEMBL275307 105156 0 None - 0 Mouse 8.2 pIC50 = 8.2 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 440 6 3 7 3.8 CCOc1cccc(-n2c(NNC(=O)Nc3cccc(C#N)c3)nc3ccccc3c2=O)c1 10.1021/jm970373j
10837829 105340 1 None - 0 Mouse 8.2 pIC50 = 8.2 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 463 6 3 6 5.0 CC(C)Oc1cccc(-n2c(NNC(=O)Nc3cccc(Cl)c3)nc3ccccc3c2=O)c1 10.1021/jm970373j
CHEMBL276627 105340 1 None - 0 Mouse 8.2 pIC50 = 8.2 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 463 6 3 6 5.0 CC(C)Oc1cccc(-n2c(NNC(=O)Nc3cccc(Cl)c3)nc3ccccc3c2=O)c1 10.1021/jm970373j
10029145 104946 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 504 7 2 5 4.6 CCOC(=O)CCN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL273919 104946 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 504 7 2 5 4.6 CCOC(=O)CCN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
44357068 171661 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 456 5 3 4 3.6 CN1C(=O)C(NC(=O)NCc2cccc(C(C)(C)O)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL422102 171661 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 456 5 3 4 3.6 CN1C(=O)C(NC(=O)NCc2cccc(C(C)(C)O)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
10601831 103279 0 None - 0 Mouse 7.3 pIC50 = 7.3 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 511 6 3 7 5.0 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(Cl)c2Cl)c1 10.1021/jm970373j
CHEMBL262569 103279 0 None - 0 Mouse 7.3 pIC50 = 7.3 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 511 6 3 7 5.0 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(Cl)c2Cl)c1 10.1021/jm970373j
CHEMBL287753 217646 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cellsBinding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cells
ChEMBL None None None CS[C@@H]1CCN(C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(C)=O)[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00001a019
10552615 36086 0 None - 0 Mouse 7.3 pIC50 = 7.3 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 477 6 3 3 5.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1CCCCC1 10.1021/jm970065l
CHEMBL138311 36086 0 None - 0 Mouse 7.3 pIC50 = 7.3 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 477 6 3 3 5.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1CCCCC1 10.1021/jm970065l
44451577 102560 0 None - 0 Mouse 7.3 pIC50 = 7.3 Binding
Binding affinity to mouse CCK2 receptorBinding affinity to mouse CCK2 receptor
ChEMBL 546 6 2 5 2.1 Cc1cccc(NC(=O)NC2C(=O)N(CC(=O)N3CCCC3)c3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 10.1016/j.bmc.2007.12.047
CHEMBL258630 102560 0 None - 0 Mouse 7.3 pIC50 = 7.3 Binding
Binding affinity to mouse CCK2 receptorBinding affinity to mouse CCK2 receptor
ChEMBL 546 6 2 5 2.1 Cc1cccc(NC(=O)NC2C(=O)N(CC(=O)N3CCCC3)c3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 10.1016/j.bmc.2007.12.047
10483574 12978 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Concentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cellsConcentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL 591 8 2 5 5.3 COc1ccc(N(C(=O)CN2C(=O)C(NC(=O)Nc3ccccc3)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm950626d
CHEMBL108130 12978 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Concentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cellsConcentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL 591 8 2 5 5.3 COc1ccc(N(C(=O)CN2C(=O)C(NC(=O)Nc3ccccc3)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm950626d
21121108 88774 2 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic aciniIn vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic acini
ChEMBL 1048 29 10 12 3.3 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 10.1016/S0960-894X(00)80679-4
CHEMBL216527 88774 2 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic aciniIn vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic acini
ChEMBL 1048 29 10 12 3.3 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 10.1016/S0960-894X(00)80679-4
CHEMBL431116 220402 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
In vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00123a003
CHEMBL386811 219172 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranesInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranes
ChEMBL None None None CCCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)OCCc1ccccc1 10.1021/jm00072a024
44356620 35434 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 400 3 3 5 2.6 CN1C(=O)C(NC(=O)Nc2ccc(N)nc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL137748 35434 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 400 3 3 5 2.6 CN1C(=O)C(NC(=O)Nc2ccc(N)nc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
11744065 85588 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 442 4 2 5 3.6 CC(=O)Oc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
CHEMBL2112750 85588 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 442 4 2 5 3.6 CC(=O)Oc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
178143 23624 2 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 440 14 2 3 5.0 CCCCCN(CCCCC)C(=O)C(CCC(=O)O)NC(=O)c1ccc2ccccc2c1 10.1021/jm00079a003
CHEMBL124832 23624 2 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 440 14 2 3 5.0 CCCCCN(CCCCC)C(=O)C(CCC(=O)O)NC(=O)c1ccc2ccccc2c1 10.1021/jm00079a003
44349083 124841 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 455 7 3 4 3.6 O=C(O)CCC(NC(=O)c1ccc(Cl)c(Cl)c1)C(=O)NN1CCC2(CCCC2)CC1 10.1021/jm00079a003
CHEMBL340463 124841 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 455 7 3 4 3.6 O=C(O)CCC(NC(=O)c1ccc(Cl)c(Cl)c1)C(=O)NN1CCC2(CCCC2)CC1 10.1021/jm00079a003
44210426 65892 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 449 4 2 4 2.2 Cc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)N3CCN(C)CC3)C2=O)c1 10.1016/S0960-894X(00)80683-6
CHEMBL169807 65892 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 449 4 2 4 2.2 Cc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)N3CCN(C)CC3)C2=O)c1 10.1016/S0960-894X(00)80683-6
44381593 127250 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Displacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptorDisplacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptor
ChEMBL 854 23 9 10 3.3 CN(C(=O)[C@H](CC(=O)O)NNC[C@H](CCCCNC(=O)/C=C\c1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80680-0
CHEMBL354171 127250 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Displacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptorDisplacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptor
ChEMBL 854 23 9 10 3.3 CN(C(=O)[C@H](CC(=O)O)NNC[C@H](CCCCNC(=O)/C=C\c1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80680-0
14208249 211411 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 387 3 2 3 3.7 Cc1ccc(C(=O)NC2N=C(c3ccccc3F)c3ccccc3NC2=O)cc1 10.1021/jm00120a002
CHEMBL73510 211411 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 387 3 2 3 3.7 Cc1ccc(C(=O)NC2N=C(c3ccccc3F)c3ccccc3NC2=O)cc1 10.1021/jm00120a002
14444006 48188 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
In vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 649 16 6 6 3.8 CC(C)CC(CC(=O)NC(CC(=O)O)C(=O)NCCc1ccccc1)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00123a003
CHEMBL149034 48188 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
In vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 649 16 6 6 3.8 CC(C)CC(CC(=O)NC(CC(=O)O)C(=O)NCCc1ccccc1)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00123a003
90663980 113587 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 891 21 8 8 4.6 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(Cl)cc1Cl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL3144549 113587 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 891 21 8 8 4.6 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(Cl)cc1Cl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
90663981 113588 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 891 21 8 8 4.6 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(Cl)c(Cl)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL3144550 113588 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 891 21 8 8 4.6 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(Cl)c(Cl)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
44280224 111561 0 None - 1 Mouse 5.3 pIC50 = 5.3 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 757 16 4 7 5.8 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL31090 111561 0 None - 1 Mouse 5.3 pIC50 = 5.3 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 757 16 4 7 5.8 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 10.1016/S0960-894X(96)00248-X
44381749 19670 0 None - 0 Human 4.3 pIC50 = 4.3 Binding
Displacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortexDisplacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortex
ChEMBL 540 14 1 4 4.9 CCCCCN(CCCCC)C(=O)C(CCC(=O)N1CCN(C)CC1)NC(=O)c1ccc(Cl)c(Cl)c1 10.1016/S0960-894X(00)80681-2
CHEMBL1188959 19670 0 None - 0 Human 4.3 pIC50 = 4.3 Binding
Displacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortexDisplacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortex
ChEMBL 540 14 1 4 4.9 CCCCCN(CCCCC)C(=O)C(CCC(=O)N1CCN(C)CC1)NC(=O)c1ccc(Cl)c(Cl)c1 10.1016/S0960-894X(00)80681-2
CHEMBL537834 19670 0 None - 0 Human 4.3 pIC50 = 4.3 Binding
Displacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortexDisplacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortex
ChEMBL 540 14 1 4 4.9 CCCCCN(CCCCC)C(=O)C(CCC(=O)N1CCN(C)CC1)NC(=O)c1ccc(Cl)c(Cl)c1 10.1016/S0960-894X(00)80681-2
14444025 113458 0 None - 0 Human 4.3 pIC50 = 4.3 Binding
In vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 692 17 7 7 2.7 CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](CC(N)=O)Cc1ccccc1 10.1021/jm00123a003
CHEMBL3143400 113458 0 None - 0 Human 4.3 pIC50 = 4.3 Binding
In vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 692 17 7 7 2.7 CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](CC(N)=O)Cc1ccccc1 10.1021/jm00123a003
44366188 172095 0 None - 0 Human 4.3 pIC50 = 4.3 Binding
In vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 692 17 7 7 2.7 CC(C)CC(CC(=O)N[C@H](CC(=O)O)C(=O)N[C@H](Cc1ccccc1)C(N)=O)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00123a003
CHEMBL423405 172095 0 None - 0 Human 4.3 pIC50 = 4.3 Binding
In vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 692 17 7 7 2.7 CC(C)CC(CC(=O)N[C@H](CC(=O)O)C(=O)N[C@H](Cc1ccccc1)C(N)=O)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00123a003
44306744 109443 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes
ChEMBL 782 20 9 7 2.5 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NC(CCCCNC(=O)Nc1ccccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccc(C)cc1)C(N)=O 10.1021/jm00001a027
CHEMBL304524 109443 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes
ChEMBL 782 20 9 7 2.5 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NC(CCCCNC(=O)Nc1ccccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccc(C)cc1)C(N)=O 10.1021/jm00001a027
CHEMBL319438 217996 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
In vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cellsIn vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL None None None CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00017a022
44306887 108838 0 None - 1 Human 4.3 pIC50 = 4.3 Binding
Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes
ChEMBL 816 18 9 7 3.4 CC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NC(Cc1cccc(NC(=O)Nc2ccccc2C)c1)C(=O)N[C@H](CC(=O)O)C(=O)N[C@@H](Cc1ccc(C)cc1)C(N)=O 10.1021/jm00001a027
CHEMBL302027 108838 0 None - 1 Human 4.3 pIC50 = 4.3 Binding
Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes
ChEMBL 816 18 9 7 3.4 CC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NC(Cc1cccc(NC(=O)Nc2ccccc2C)c1)C(=O)N[C@H](CC(=O)O)C(=O)N[C@@H](Cc1ccc(C)cc1)C(N)=O 10.1021/jm00001a027
44349150 24397 0 None - 0 Rat 4.3 pIC50 = 4.3 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 340 9 3 3 2.2 CCCCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 10.1021/jm00079a003
CHEMBL125829 24397 0 None - 0 Rat 4.3 pIC50 = 4.3 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 340 9 3 3 2.2 CCCCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 10.1021/jm00079a003
10651635 172051 0 None - 1 Rat 6.3 pIC50 = 6.3 Binding
Inhibitory activity against CCK-B receptorInhibitory activity against CCK-B receptor
ChEMBL 630 9 3 7 5.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1C[C@H](Oc2ccc([N+](=O)[O-])cc2)C[C@@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
CHEMBL423119 172051 0 None - 1 Rat 6.3 pIC50 = 6.3 Binding
Inhibitory activity against CCK-B receptorInhibitory activity against CCK-B receptor
ChEMBL 630 9 3 7 5.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1C[C@H](Oc2ccc([N+](=O)[O-])cc2)C[C@@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
44375448 126666 0 None - 0 Mouse 6.3 pIC50 = 6.3 Binding
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 596 13 5 7 4.2 O=C(O)CCN(Cc1ccccc1)S(=O)(=O)c1ccc(N/N=C(/S)NCCc2c[nH]c3ccccc23)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
CHEMBL349046 126666 0 None - 0 Mouse 6.3 pIC50 = 6.3 Binding
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 596 13 5 7 4.2 O=C(O)CCN(Cc1ccccc1)S(=O)(=O)c1ccc(N/N=C(/S)NCCc2c[nH]c3ccccc23)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
90663993 113599 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 901 21 8 8 4.0 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(Br)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL3144562 113599 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 901 21 8 8 4.0 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(Br)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
44368594 127829 0 None - 0 Mouse 6.3 pIC50 = 6.3 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 447 8 3 3 4.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1CCCCC1)C(=O)NCCc1ccccc1 10.1021/jm00057a005
CHEMBL356810 127829 0 None - 0 Mouse 6.3 pIC50 = 6.3 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 447 8 3 3 4.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1CCCCC1)C(=O)NCCc1ccccc1 10.1021/jm00057a005
10318742 31779 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 399 3 2 4 3.4 Cc1cccc(NC(=O)NC2N=C(c3ccncc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
CHEMBL134657 31779 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 399 3 2 4 3.4 Cc1cccc(NC(=O)NC2N=C(c3ccncc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
10071645 34767 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 435 3 2 4 4.2 CN1C(=O)C(NC(=O)Nc2ccc3ncccc3c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL137238 34767 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 435 3 2 4 4.2 CN1C(=O)C(NC(=O)Nc2ccc3ncccc3c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
44331849 118266 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL 551 3 0 4 5.7 CC(C)(C)OC(=O)N1c2ccccc2C[C@@H]1C(=O)N1[C@H](c2ccccc2)CC[C@@H]1C(=O)N1CCc2ccccc2C1 10.1016/S0960-894X(96)00546-X
CHEMBL327727 118266 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL 551 3 0 4 5.7 CC(C)(C)OC(=O)N1c2ccccc2C[C@@H]1C(=O)N1[C@H](c2ccccc2)CC[C@@H]1C(=O)N1CCc2ccccc2C1 10.1016/S0960-894X(96)00546-X
10350551 115232 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL 838 21 8 7 3.9 Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
CHEMBL319913 115232 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL 838 21 8 7 3.9 Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
CHEMBL317477 217982 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL None None None COC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
10320031 84600 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 421 3 1 3 4.0 CN1C(=O)[C@H](NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL2092868 84600 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 421 3 1 3 4.0 CN1C(=O)[C@H](NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
14991577 170023 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 870 20 9 8 4.0 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1cc2cc(Cl)ccc2[nH]1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL418500 170023 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 870 20 9 8 4.0 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1cc2cc(Cl)ccc2[nH]1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
5279123 211320 1 None - 0 Human 4.3 pIC50 = 4.3 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 389 3 2 3 3.9 O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccccc1Cl 10.1021/jm00120a002
CHEMBL72841 211320 1 None - 0 Human 4.3 pIC50 = 4.3 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 389 3 2 3 3.9 O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccccc1Cl 10.1021/jm00120a002
11707484 139917 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Displacement of [3H]propionylCCK8 from rat cerebral cortex CCK2Displacement of [3H]propionylCCK8 from rat cerebral cortex CCK2
ChEMBL 717 10 6 6 3.7 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1C[C@@H]2c3[nH]c4ccccc4c3C[C@@H](C(=O)N[C@H](Cc3ccccc3)C(N)=O)N2C1=O 10.1021/jm050689o
CHEMBL370355 139917 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Displacement of [3H]propionylCCK8 from rat cerebral cortex CCK2Displacement of [3H]propionylCCK8 from rat cerebral cortex CCK2
ChEMBL 717 10 6 6 3.7 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1C[C@@H]2c3[nH]c4ccccc4c3C[C@@H](C(=O)N[C@H](Cc3ccccc3)C(N)=O)N2C1=O 10.1021/jm050689o
10627173 213321 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8
ChEMBL 586 8 1 4 6.5 COc1ccc(N(C(=O)CN2C(=O)C(Cc3c[nH]c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm960249k
CHEMBL88602 213321 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8
ChEMBL 586 8 1 4 6.5 COc1ccc(N(C(=O)CN2C(=O)C(Cc3c[nH]c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm960249k
10627173 213321 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 586 8 1 4 6.5 COc1ccc(N(C(=O)CN2C(=O)C(Cc3c[nH]c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm970265x
CHEMBL88602 213321 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 586 8 1 4 6.5 COc1ccc(N(C(=O)CN2C(=O)C(Cc3c[nH]c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm970265x
10392523 214723 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 540 6 3 3 5.9 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)NC(C)(C)C)C2=O)c1 10.1016/S0960-894X(01)80832-5
CHEMBL96970 214723 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 540 6 3 3 5.9 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)NC(C)(C)C)C2=O)c1 10.1016/S0960-894X(01)80832-5
44381463 103601 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
In vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranesIn vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranes
ChEMBL 1124 30 10 12 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80679-4
CHEMBL265147 103601 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
In vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranesIn vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranes
ChEMBL 1124 30 10 12 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80679-4
CHEMBL2370119 216564 0 None - 0 Bovine 7.3 pIC50 = 7.3 Binding
Inhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranesInhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranes
ChEMBL None None None CSCC[C@H](NC(=O)C(Cc1cccc(CC(=O)O)c1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00107a037
44334345 170633 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 504 8 2 4 4.0 Cc1cccc(NC(=O)N[C@H](CCC(=O)N2CCCC2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
CHEMBL420658 170633 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 504 8 2 4 4.0 Cc1cccc(NC(=O)N[C@H](CCC(=O)N2CCCC2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
14208297 74520 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 513 3 1 3 4.0 CN1C(=O)[C@@H](NC(=O)c2ccc(I)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL1907848 74520 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 513 3 1 3 4.0 CN1C(=O)[C@@H](NC(=O)c2ccc(I)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
90663983 113590 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 891 21 8 8 4.3 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(C(F)(F)F)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL3144552 113590 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 891 21 8 8 4.3 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(C(F)(F)F)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
44327420 118363 0 None - 0 Mouse 6.3 pIC50 = 6.3 Binding
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 571 10 2 5 5.3 COC(=O)CN(CCc1ccccc1)C(=O)[C@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1016/S0960-894X(01)80769-1
CHEMBL328213 118363 0 None - 0 Mouse 6.3 pIC50 = 6.3 Binding
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 571 10 2 5 5.3 COC(=O)CN(CCc1ccccc1)C(=O)[C@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1016/S0960-894X(01)80769-1
155553269 180906 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1818 68 15 22 3.9 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N1CCC[C@@H]1C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4545970 180906 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1818 68 15 22 3.9 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N1CCC[C@@H]1C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
44280694 107056 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 571 11 3 5 4.4 CSCCC(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O 10.1021/jm950372w
CHEMBL289018 107056 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 571 11 3 5 4.4 CSCCC(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O 10.1021/jm950372w
10649303 214235 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Compound was evaluated for functional activity on Cholecystokinin type B receptor (CCK-B) receptor carried out on guinea pig stomach cells.Compound was evaluated for functional activity on Cholecystokinin type B receptor (CCK-B) receptor carried out on guinea pig stomach cells.
ChEMBL 507 6 3 6 5.1 CC(C)Oc1cccc(-n2c(NNC(=O)Nc3ccc(Br)cc3)nc3ccccc3c2=O)c1 10.1021/jm970373j
CHEMBL9422 214235 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Compound was evaluated for functional activity on Cholecystokinin type B receptor (CCK-B) receptor carried out on guinea pig stomach cells.Compound was evaluated for functional activity on Cholecystokinin type B receptor (CCK-B) receptor carried out on guinea pig stomach cells.
ChEMBL 507 6 3 6 5.1 CC(C)Oc1cccc(-n2c(NNC(=O)Nc3ccc(Br)cc3)nc3ccccc3c2=O)c1 10.1021/jm970373j
44373701 59265 0 None - 0 Mouse 7.3 pIC50 = 7.3 Binding
Compound was tested for the inhibition of specific binding of [125I]bolton Hunter CCK-8 to Cholecystokinin type B receptor in mouse cerebral cortexCompound was tested for the inhibition of specific binding of [125I]bolton Hunter CCK-8 to Cholecystokinin type B receptor in mouse cerebral cortex
ChEMBL 541 8 4 4 5.3 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N/C(=C\c1ccccc1)C(=O)O 10.1016/S0960-894X(01)81250-6
CHEMBL159138 59265 0 None - 0 Mouse 7.3 pIC50 = 7.3 Binding
Compound was tested for the inhibition of specific binding of [125I]bolton Hunter CCK-8 to Cholecystokinin type B receptor in mouse cerebral cortexCompound was tested for the inhibition of specific binding of [125I]bolton Hunter CCK-8 to Cholecystokinin type B receptor in mouse cerebral cortex
ChEMBL 541 8 4 4 5.3 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N/C(=C\c1ccccc1)C(=O)O 10.1016/S0960-894X(01)81250-6
CHEMBL2079549 215971 0 None - 0 Bovine 7.3 pIC50 = 7.3 Binding
Inhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranesInhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccc(CC(=O)O)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00107a037
10046672 122860 2 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 402 3 2 3 3.8 CN1C(=O)C(NC(=O)Nc2cccc(F)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL335666 122860 2 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 402 3 2 3 3.8 CN1C(=O)C(NC(=O)Nc2cccc(F)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
10813333 112130 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 447 5 2 4 4.2 CCCN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C([C@H]2CCCCN2C)c2ccccc21 10.1021/jm9608523
CHEMBL311638 112130 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 447 5 2 4 4.2 CCCN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C([C@H]2CCCCN2C)c2ccccc21 10.1021/jm9608523
10070678 127533 1 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 418 3 2 3 4.3 CN1C(=O)[C@@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00121a004
CHEMBL355092 127533 1 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 418 3 2 3 4.3 CN1C(=O)[C@@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00121a004
44382562 65874 0 None - 0 Mouse 6.3 pIC50 = 6.3 Binding
Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 662 13 5 5 5.8 O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccc(O)cc1)NCCc1ccccc1 10.1016/S0960-894X(00)80687-3
CHEMBL169710 65874 0 None - 0 Mouse 6.3 pIC50 = 6.3 Binding
Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 662 13 5 5 5.8 O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccc(O)cc1)NCCc1ccccc1 10.1016/S0960-894X(00)80687-3
44280117 108828 0 None - 0 Mouse 6.3 pIC50 = 6.3 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 672 12 3 6 5.9 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL30195 108828 0 None - 0 Mouse 6.3 pIC50 = 6.3 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 672 12 3 6 5.9 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 10.1016/S0960-894X(96)00248-X
10070678 127533 1 None - 0 Human 6.3 pIC50 = 6.3 Binding
Tested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pigTested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pig
ChEMBL 418 3 2 3 4.3 CN1C(=O)[C@@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80682-4
CHEMBL355092 127533 1 None - 0 Human 6.3 pIC50 = 6.3 Binding
Tested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pigTested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pig
ChEMBL 418 3 2 3 4.3 CN1C(=O)[C@@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80682-4
44210428 65888 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 485 4 2 4 3.1 CN1CCN(C(=O)CN2C(=O)C(NC(=O)Nc3cccc4ccccc34)CCc3ccccc32)CC1 10.1016/S0960-894X(00)80683-6
CHEMBL169794 65888 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 485 4 2 4 3.1 CN1CCN(C(=O)CN2C(=O)C(NC(=O)Nc3cccc4ccccc34)CCc3ccccc32)CC1 10.1016/S0960-894X(00)80683-6
14208254 211285 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 403 4 2 4 3.4 COc1ccc(C(=O)NC2N=C(c3ccccc3F)c3ccccc3NC2=O)cc1 10.1021/jm00120a002
CHEMBL72599 211285 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 403 4 2 4 3.4 COc1ccc(C(=O)NC2N=C(c3ccccc3F)c3ccccc3NC2=O)cc1 10.1021/jm00120a002
10345812 25422 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 498 5 3 3 5.0 Cc1ccccc1NC(=O)N[C@@H]1C[C@H](c2ccccc2)c2ccccc2N(CC(=O)NC(C)(C)C)C1=O 10.1021/jm00048a015
CHEMBL127687 25422 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 498 5 3 3 5.0 Cc1ccccc1NC(=O)N[C@@H]1C[C@H](c2ccccc2)c2ccccc2N(CC(=O)NC(C)(C)C)C1=O 10.1021/jm00048a015
14843034 106917 0 None - 0 Mouse 7.3 pIC50 = 7.3 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 409 5 1 4 5.0 COc1cccc(-n2c(CCc3c[nH]c4ccc(C)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
CHEMBL287739 106917 0 None - 0 Mouse 7.3 pIC50 = 7.3 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 409 5 1 4 5.0 COc1cccc(-n2c(CCc3c[nH]c4ccc(C)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
14208259 210936 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 545 4 1 4 5.9 O=C(NC1N=C(c2ccccc2F)c2ccccc2N(C(=O)c2ccc(Cl)cc2)C1=O)c1ccc(Cl)cc1 10.1021/jm00120a002
CHEMBL70593 210936 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 545 4 1 4 5.9 O=C(NC1N=C(c2ccccc2F)c2ccccc2N(C(=O)c2ccc(Cl)cc2)C1=O)c1ccc(Cl)cc1 10.1021/jm00120a002
44382563 127530 0 None - 0 Mouse 6.3 pIC50 = 6.3 Binding
Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 742 15 5 7 5.3 O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1)NCCc1ccc(OS(=O)(=O)O)cc1 10.1016/S0960-894X(00)80687-3
CHEMBL355052 127530 0 None - 0 Mouse 6.3 pIC50 = 6.3 Binding
Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 742 15 5 7 5.3 O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1)NCCc1ccc(OS(=O)(=O)O)cc1 10.1016/S0960-894X(00)80687-3
44280388 123647 0 None - 1 Mouse 6.3 pIC50 = 6.3 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 759 15 4 8 5.0 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL33819 123647 0 None - 1 Mouse 6.3 pIC50 = 6.3 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 759 15 4 8 5.0 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
44280115 114004 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 658 11 3 6 5.8 CN1C(=O)[C@H](NC(=O)Nc2cccc(C(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
CHEMBL31671 114004 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 658 11 3 6 5.8 CN1C(=O)[C@H](NC(=O)Nc2cccc(C(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
44382706 65794 2 None - 0 Mouse 6.3 pIC50 = 6.3 Binding
The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in mouse brain at a pH of 7.4The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in mouse brain at a pH of 7.4
ChEMBL 475 3 2 2 5.9 O=C1NN(C(=S)Nc2ccc(Cl)c(C(F)(F)F)c2)[C@@H](c2ccccc2)[C@@H]1c1ccccc1 10.1016/S0960-894X(00)80684-8
CHEMBL169274 65794 2 None - 0 Mouse 6.3 pIC50 = 6.3 Binding
The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in mouse brain at a pH of 7.4The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in mouse brain at a pH of 7.4
ChEMBL 475 3 2 2 5.9 O=C1NN(C(=S)Nc2ccc(Cl)c(C(F)(F)F)c2)[C@@H](c2ccccc2)[C@@H]1c1ccccc1 10.1016/S0960-894X(00)80684-8
19766161 65957 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 403 4 3 3 3.4 O=C(O)CN1C(=O)C(NC(=O)Nc2cccc3ccccc23)CCc2ccccc21 10.1016/S0960-894X(00)80683-6
CHEMBL170068 65957 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 403 4 3 3 3.4 O=C(O)CN1C(=O)C(NC(=O)Nc2cccc3ccccc23)CCc2ccccc21 10.1016/S0960-894X(00)80683-6
44311988 109808 0 None - 0 Human 4.3 pIC50 = 4.3 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 412 5 2 4 2.5 CN1C(=O)[C@H](NC(=O)[C@H](N)Cc2ccccc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
CHEMBL307034 109808 0 None - 0 Human 4.3 pIC50 = 4.3 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 412 5 2 4 2.5 CN1C(=O)[C@H](NC(=O)[C@H](N)Cc2ccccc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
44359881 126080 0 None - 0 Human 4.3 pIC50 = 4.3 Binding
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 473 8 1 5 4.1 CN1c2ccccc2C(c2ccccc2F)=NCC1CNC(=O)CCC(=O)OCc1ccccc1 10.1021/jm00163a069
CHEMBL343969 126080 0 None - 0 Human 4.3 pIC50 = 4.3 Binding
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 473 8 1 5 4.1 CN1c2ccccc2C(c2ccccc2F)=NCC1CNC(=O)CCC(=O)OCc1ccccc1 10.1021/jm00163a069
136055866 63291 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
The compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligandThe compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligand
ChEMBL 468 4 3 7 3.4 CN1C(=O)[C@H](NC(=O)Nc2ccc(-c3noc(O)n3)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00032a003
CHEMBL163610 63291 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
The compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligandThe compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligand
ChEMBL 468 4 3 7 3.4 CN1C(=O)[C@H](NC(=O)Nc2ccc(-c3noc(O)n3)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00032a003
135494573 173526 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
Displacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting methodDisplacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting method
ChEMBL 395 3 2 6 3.5 Cc1ccc(-n2c(N/N=C3\C(=O)Nc4ccccc43)nc3ccccc3c2=O)cc1 10.1039/C7MD00171A
CHEMBL4283467 173526 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
Displacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting methodDisplacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting method
ChEMBL 395 3 2 6 3.5 Cc1ccc(-n2c(N/N=C3\C(=O)Nc4ccccc43)nc3ccccc3c2=O)cc1 10.1039/C7MD00171A
44329442 214451 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 540 6 3 3 5.9 Cc1ccc([C@H]2C[C@@H](c3ccccc3)C[C@@H](NC(=O)Nc3cccc(C)c3)C(=O)N2CC(=O)NC(C)(C)C)cc1 10.1016/S0960-894X(01)80832-5
CHEMBL95369 214451 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 540 6 3 3 5.9 Cc1ccc([C@H]2C[C@@H](c3ccccc3)C[C@@H](NC(=O)Nc3cccc(C)c3)C(=O)N2CC(=O)NC(C)(C)C)cc1 10.1016/S0960-894X(01)80832-5
CHEMBL3142689 217910 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL None None None CC(C)(C)NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
13605417 214347 4 None - 1 Human 5.3 pIC50 = 5.3 Binding
Displacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortexDisplacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortex
ChEMBL 458 14 2 3 5.2 CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1ccc(Cl)c(Cl)c1 10.1016/S0960-894X(00)80681-2
CHEMBL9485 214347 4 None - 1 Human 5.3 pIC50 = 5.3 Binding
Displacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortexDisplacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortex
ChEMBL 458 14 2 3 5.2 CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1ccc(Cl)c(Cl)c1 10.1016/S0960-894X(00)80681-2
15104618 115818 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 496 13 3 2 6.8 CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)Nc1ccc(Cl)cc1 10.1021/jm00116a002
CHEMBL321265 115818 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 496 13 3 2 6.8 CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)Nc1ccc(Cl)cc1 10.1021/jm00116a002
44408632 165016 0 None -2454 4 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1212 31 12 15 3.8 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@H](Cc1cn(C(=O)OC23CC4CC(CC(C4)C2)C3)c2ccccc12)C(=O)O 10.1021/jm050851n
CHEMBL408832 165016 0 None -2454 4 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1212 31 12 15 3.8 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@H](Cc1cn(C(=O)OC23CC4CC(CC(C4)C2)C3)c2ccccc12)C(=O)O 10.1021/jm050851n
155555065 181113 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1836 71 17 23 2.9 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4550876 181113 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1836 71 17 23 2.9 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
11801355 123646 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
In vitro inhibition of [3H]propionyl-CCK-8 binding to rat cerebral cortex membranes at Cholecystokinin type B receptor.In vitro inhibition of [3H]propionyl-CCK-8 binding to rat cerebral cortex membranes at Cholecystokinin type B receptor.
ChEMBL 580 8 3 6 3.6 COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H]1Cc2c([nH]c3ccccc23)[C@@H]2C[C@@H](NC(=O)OCc3ccccc3)C(=O)N21 10.1021/jm000959x
CHEMBL338186 123646 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
In vitro inhibition of [3H]propionyl-CCK-8 binding to rat cerebral cortex membranes at Cholecystokinin type B receptor.In vitro inhibition of [3H]propionyl-CCK-8 binding to rat cerebral cortex membranes at Cholecystokinin type B receptor.
ChEMBL 580 8 3 6 3.6 COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H]1Cc2c([nH]c3ccccc23)[C@@H]2C[C@@H](NC(=O)OCc3ccccc3)C(=O)N21 10.1021/jm000959x
10744012 104154 0 None - 0 Mouse 7.2 pIC50 = 7.2 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 501 8 3 8 4.5 CCOC(=O)c1ccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(OC(C)C)c2)cc1 10.1021/jm970373j
CHEMBL269662 104154 0 None - 0 Mouse 7.2 pIC50 = 7.2 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 501 8 3 8 4.5 CCOC(=O)c1ccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(OC(C)C)c2)cc1 10.1021/jm970373j
73349806 103217 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranesInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranes
ChEMBL 1019 29 9 11 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCOc1ccccc1)CC(=O)O 10.1021/jm00072a024
CHEMBL262155 103217 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranesInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranes
ChEMBL 1019 29 9 11 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCOc1ccccc1)CC(=O)O 10.1021/jm00072a024
44280122 106275 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 640 10 3 4 5.7 CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)[C@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm950372w
CHEMBL283276 106275 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 640 10 3 4 5.7 CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)[C@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm950372w
44280622 125992 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 698 12 4 5 5.9 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2c1CCCC2 10.1021/jm950372w
CHEMBL34332 125992 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 698 12 4 5 5.9 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2c1CCCC2 10.1021/jm950372w
6918156 104063 4 None - 0 Human 6.2 pIC50 = 6.2 Binding
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 990 29 9 11 2.0 CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
CHEMBL269016 104063 4 None - 0 Human 6.2 pIC50 = 6.2 Binding
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 990 29 9 11 2.0 CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
14991585 107803 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 919 21 7 10 4.3 CC(=O)Oc1ccc2cc(C(=O)NCCCC[C@H](NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc3ccccc3)C(N)=O)ccc2c1 10.1021/jm00089a010
CHEMBL294542 107803 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 919 21 7 10 4.3 CC(=O)Oc1ccc2cc(C(=O)NCCCC[C@H](NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc3ccccc3)C(N)=O)ccc2c1 10.1021/jm00089a010
44279862 105906 0 None - 1 Human 6.2 pIC50 = 6.2 Binding
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 702 13 3 7 5.9 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL281017 105906 0 None - 1 Human 6.2 pIC50 = 6.2 Binding
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 702 13 3 7 5.9 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
15689730 113373 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 854 21 9 8 4.4 CC(C)c1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
CHEMBL3142694 113373 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 854 21 9 8 4.4 CC(C)c1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
10079035 170640 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL 796 21 8 7 2.9 CCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
CHEMBL420667 170640 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL 796 21 8 7 2.9 CCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
44334379 115550 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 435 7 2 3 4.7 Cc1cccc(NC(=O)N[C@H](CC(C)C)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
CHEMBL320901 115550 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 435 7 2 3 4.7 Cc1cccc(NC(=O)N[C@H](CC(C)C)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
155540739 179286 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1907 74 17 24 2.5 CCCC[C@H](NC(=O)[C@H](Cc1cc2ccccc2[nH]1)NC(=O)CNC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(C)=O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4483457 179286 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1907 74 17 24 2.5 CCCC[C@H](NC(=O)[C@H](Cc1cc2ccccc2[nH]1)NC(=O)CNC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(C)=O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
10009894 32400 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
Inhibition of [3H]propionyl-CCK-8 specific binding to rat cerebral cortex membranes Cholecystokinin type B receptorInhibition of [3H]propionyl-CCK-8 specific binding to rat cerebral cortex membranes Cholecystokinin type B receptor
ChEMBL 694 13 6 6 4.9 Cc1ccccc1NC(=O)NCCCC[C@@H](CC(=O)O)NC(=O)[C@H]1Cc2c([nH]c3ccccc23)[C@@H]2C[C@@H](NC(=O)OCc3ccccc3)C(=O)N21 10.1016/s0960-894x(01)00630-8
CHEMBL13517 32400 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
Inhibition of [3H]propionyl-CCK-8 specific binding to rat cerebral cortex membranes Cholecystokinin type B receptorInhibition of [3H]propionyl-CCK-8 specific binding to rat cerebral cortex membranes Cholecystokinin type B receptor
ChEMBL 694 13 6 6 4.9 Cc1ccccc1NC(=O)NCCCC[C@@H](CC(=O)O)NC(=O)[C@H]1Cc2c([nH]c3ccccc23)[C@@H]2C[C@@H](NC(=O)OCc3ccccc3)C(=O)N21 10.1016/s0960-894x(01)00630-8
14843039 125553 0 None - 0 Mouse 7.2 pIC50 = 7.2 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 501 7 1 4 6.2 CCCOc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
CHEMBL34198 125553 0 None - 0 Mouse 7.2 pIC50 = 7.2 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 501 7 1 4 6.2 CCCOc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
44303233 107431 0 None - 0 Mouse 7.2 pIC50 = 7.2 Binding
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 632 12 5 5 5.0 C[C@](Cc1c[nH]c2ccc(F)cc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1 10.1016/S0960-894X(97)00356-9
CHEMBL292194 107431 0 None - 0 Mouse 7.2 pIC50 = 7.2 Binding
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 632 12 5 5 5.0 C[C@](Cc1c[nH]c2ccc(F)cc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1 10.1016/S0960-894X(97)00356-9
10416987 18981 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 539 5 2 4 3.2 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)N3CC[N+](C)(C)CC3)C2=O)c1 10.1021/jm00078a018
CHEMBL1184312 18981 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 539 5 2 4 3.2 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)N3CC[N+](C)(C)CC3)C2=O)c1 10.1021/jm00078a018
CHEMBL343949 18981 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 539 5 2 4 3.2 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)N3CC[N+](C)(C)CC3)C2=O)c1 10.1021/jm00078a018
14208300 84598 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 465 3 1 3 4.2 CN1C(=O)[C@H](NC(=O)c2ccccc2Br)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL2092866 84598 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 465 3 1 3 4.2 CN1C(=O)[C@H](NC(=O)c2ccccc2Br)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
44349392 23590 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 394 7 3 3 3.4 CC1(C)CCC(NC(=O)C(CCC(=O)O)NC(=O)c2cccc(Cl)c2)CC1 10.1021/jm00079a003
CHEMBL124712 23590 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 394 7 3 3 3.4 CC1(C)CCC(NC(=O)C(CCC(=O)O)NC(=O)c2cccc(Cl)c2)CC1 10.1021/jm00079a003
71461592 85261 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 421 7 3 4 3.0 O=C(O)CC[C@H](NC(=O)c1cccc(Cl)c1)C(=O)NN1CCC2(CCCC2)CC1 10.1021/jm00079a003
CHEMBL2111828 85261 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 421 7 3 4 3.0 O=C(O)CC[C@H](NC(=O)c1cccc(Cl)c1)C(=O)NN1CCC2(CCCC2)CC1 10.1021/jm00079a003
10530003 103778 0 None - 0 Mouse 6.2 pIC50 = 6.2 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 520 7 2 5 5.3 CC(C)Oc1cccc(-n2c(CCNC(=O)Nc3ccc(Br)cc3)nc3ccccc3c2=O)c1 10.1021/jm970373j
CHEMBL266598 103778 0 None - 0 Mouse 6.2 pIC50 = 6.2 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 520 7 2 5 5.3 CC(C)Oc1cccc(-n2c(CCNC(=O)Nc3ccc(Br)cc3)nc3ccccc3c2=O)c1 10.1021/jm970373j
10530003 103778 0 None - 0 Mouse 6.2 pIC50 = 6.2 Binding
Inhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 520 7 2 5 5.3 CC(C)Oc1cccc(-n2c(CCNC(=O)Nc3ccc(Br)cc3)nc3ccccc3c2=O)c1 10.1016/S0960-894X(97)00108-X
CHEMBL266598 103778 0 None - 0 Mouse 6.2 pIC50 = 6.2 Binding
Inhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 520 7 2 5 5.3 CC(C)Oc1cccc(-n2c(CCNC(=O)Nc3ccc(Br)cc3)nc3ccccc3c2=O)c1 10.1016/S0960-894X(97)00108-X
10698905 213651 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 605 8 1 5 6.0 COc1ccc(N(C(=O)CN2C(=O)C(Cc3n[nH]c4cc(F)ccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm970265x
CHEMBL90697 213651 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 605 8 1 5 6.0 COc1ccc(N(C(=O)CN2C(=O)C(Cc3n[nH]c4cc(F)ccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm970265x
10027443 123310 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 464 5 3 4 4.3 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(Cc3ncc[nH]3)C2=O)c1 10.1021/jm00078a018
CHEMBL336221 123310 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 464 5 3 4 4.3 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(Cc3ncc[nH]3)C2=O)c1 10.1021/jm00078a018
14991534 113569 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 825 22 8 8 3.2 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL3144531 113569 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 825 22 8 8 3.2 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
44381960 127057 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Tested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brainTested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL 474 3 3 4 4.6 CN1C(=O)[C@@H](NC(=O)Nc2cc3c4ccccc4nc-3c[nH]2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80682-4
CHEMBL352573 127057 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Tested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brainTested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL 474 3 3 4 4.6 CN1C(=O)[C@@H](NC(=O)Nc2cc3c4ccccc4nc-3c[nH]2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80682-4
10576429 213413 0 None - 0 Mouse 6.2 pIC50 = 6.2 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 473 7 3 8 3.7 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2ccc(OC)cc2)c1 10.1021/jm970373j
CHEMBL8920 213413 0 None - 0 Mouse 6.2 pIC50 = 6.2 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 473 7 3 8 3.7 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2ccc(OC)cc2)c1 10.1021/jm970373j
CHEMBL2386887 217178 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of Eu-DTPA-CCK8 from CCK2 receptor in HEK293 cells after 2 hrs by TRF assayDisplacement of Eu-DTPA-CCK8 from CCK2 receptor in HEK293 cells after 2 hrs by TRF assay
ChEMBL None None None C#CCCC(=O)NCCCC[C@H](NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1cn(CC(=O)NCC(=O)N2CCC[C@H]2C(=O)NCC(=O)NCCCC(CCCNC(=O)CNC(=O)[C@@H]2CCCN2C(=O)CNC(=O)Cn2cc(NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCC)N(C)C(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCCNC(=O)CCC#C)NC(C)=O)nn2)(NC(=O)CNC(=O)CNC(=O)[C@@H]2CCCN2C(=O)CNC(=O)Cn2cc(NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCC)N(C)C(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCCNC(=O)CCC#C)NC(C)=O)nn2)C(=O)NCCC(N)=O)nn1 10.1016/j.bmcl.2013.02.022
73349793 213235 0 None - 0 Mouse 8.2 pIC50 = 8.2 Binding
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 638 12 5 7 4.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCc1nnn[nH]1)c1ccccc1 10.1021/jm00092a007
CHEMBL88090 213235 0 None - 0 Mouse 8.2 pIC50 = 8.2 Binding
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 638 12 5 7 4.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCc1nnn[nH]1)c1ccccc1 10.1021/jm00092a007
44356788 123484 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 496 6 3 4 4.3 O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(C[C@@H](O)CCl)C1=O 10.1021/jm00078a018
CHEMBL337286 123484 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 496 6 3 4 4.3 O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(C[C@@H](O)CCl)C1=O 10.1021/jm00078a018
10408567 126057 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 398 3 2 3 4.0 Cc1ccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc1 10.1021/jm00078a018
CHEMBL343767 126057 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 398 3 2 3 4.0 Cc1ccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc1 10.1021/jm00078a018
4627 7609 50 None 1 5 Rat 8.2 pIC50 = 8.2 Binding
Tested for the inhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane(CCK-B)Tested for the inhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane(CCK-B)
ChEMBL None None None None 10.1016/S0960-894X(97)00107-8
864 7609 50 None 1 5 Rat 8.2 pIC50 = 8.2 Binding
Tested for the inhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane(CCK-B)Tested for the inhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane(CCK-B)
ChEMBL None None None None 10.1016/S0960-894X(97)00107-8
9833444 7609 50 None 1 5 Rat 8.2 pIC50 = 8.2 Binding
Tested for the inhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane(CCK-B)Tested for the inhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane(CCK-B)
ChEMBL None None None None 10.1016/S0960-894X(97)00107-8
CHEMBL1121 7609 50 None 1 5 Rat 8.2 pIC50 = 8.2 Binding
Tested for the inhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane(CCK-B)Tested for the inhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane(CCK-B)
ChEMBL None None None None 10.1016/S0960-894X(97)00107-8
DB09142 7609 50 None 1 5 Rat 8.2 pIC50 = 8.2 Binding
Tested for the inhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane(CCK-B)Tested for the inhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane(CCK-B)
ChEMBL None None None None 10.1016/S0960-894X(97)00107-8
44367000 126474 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 494 6 2 4 5.1 Cc1cccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1016/0960-894X(95)00556-9
CHEMBL347329 126474 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 494 6 2 4 5.1 Cc1cccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1016/0960-894X(95)00556-9
44303243 209704 0 None - 0 Mouse 8.2 pIC50 = 8.2 Binding
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 545 9 5 5 4.2 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CO)[C@H](O)c1ccccc1 10.1016/S0960-894X(97)00356-9
CHEMBL62832 209704 0 None - 0 Mouse 8.2 pIC50 = 8.2 Binding
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 545 9 5 5 4.2 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CO)[C@H](O)c1ccccc1 10.1016/S0960-894X(97)00356-9
44359376 126137 1 None - 0 Mouse 8.2 pIC50 = 8.2 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 493 6 4 4 4.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1CCCCC1O 10.1021/jm970065l
CHEMBL344380 126137 1 None - 0 Mouse 8.2 pIC50 = 8.2 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 493 6 4 4 4.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1CCCCC1O 10.1021/jm970065l
44283055 123390 0 None - 0 Mouse 8.2 pIC50 = 8.2 Binding
Evaluated for in vitro binding affinity towards cholecystokinin-B (CCK-B) receptor in mouse cerebral cortex using [125I]bolton hunter CCK-26-33 as radioligand; 4.2-8.9Evaluated for in vitro binding affinity towards cholecystokinin-B (CCK-B) receptor in mouse cerebral cortex using [125I]bolton hunter CCK-26-33 as radioligand; 4.2-8.9
ChEMBL 515 9 4 4 4.4 O=C(NC(Cc1c[nH]c2ccccc12)C(=O)NC(CO)Cc1ccccc1)OC1C2CC3CC(C2)CC1C3 10.1016/S0960-894X(00)80156-0
CHEMBL336769 123390 0 None - 0 Mouse 8.2 pIC50 = 8.2 Binding
Evaluated for in vitro binding affinity towards cholecystokinin-B (CCK-B) receptor in mouse cerebral cortex using [125I]bolton hunter CCK-26-33 as radioligand; 4.2-8.9Evaluated for in vitro binding affinity towards cholecystokinin-B (CCK-B) receptor in mouse cerebral cortex using [125I]bolton hunter CCK-26-33 as radioligand; 4.2-8.9
ChEMBL 515 9 4 4 4.4 O=C(NC(Cc1c[nH]c2ccccc12)C(=O)NC(CO)Cc1ccccc1)OC1C2CC3CC(C2)CC1C3 10.1016/S0960-894X(00)80156-0
73346724 212867 0 None - 0 Mouse 8.2 pIC50 = 8.2 Binding
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 681 13 5 9 5.0 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCC(=O)NC1N=NN=N1)c1ccccc1 10.1021/jm00092a007
CHEMBL85607 212867 0 None - 0 Mouse 8.2 pIC50 = 8.2 Binding
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 681 13 5 9 5.0 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCC(=O)NC1N=NN=N1)c1ccccc1 10.1021/jm00092a007
9984452 172082 0 None - 0 Mouse 8.2 pIC50 = 8.2 Binding
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 529 9 4 4 4.7 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00105a062
CHEMBL423329 172082 0 None - 0 Mouse 8.2 pIC50 = 8.2 Binding
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 529 9 4 4 4.7 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00105a062
44368624 127911 0 None - 0 Mouse 8.2 pIC50 = 8.2 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 513 9 4 3 4.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)C1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
CHEMBL357564 127911 0 None - 0 Mouse 8.2 pIC50 = 8.2 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 513 9 4 3 4.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)C1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
9984452 36487 0 None - 1 Mouse 8.2 pIC50 = 8.2 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 529 9 4 4 4.7 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm970065l
CHEMBL138657 36487 0 None - 1 Mouse 8.2 pIC50 = 8.2 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 529 9 4 4 4.7 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm970065l
15673180 92772 0 None - 0 Mouse 8.2 pIC50 = 8.2 Binding
The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the mouse cerebral cortex (CCK-B);value ranges from 5.3 to 7.7The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the mouse cerebral cortex (CCK-B);value ranges from 5.3 to 7.7
ChEMBL 681 13 6 8 3.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)Nc1nn[nH]n1)c1ccccc1 10.1016/S0960-894X(00)80652-6
CHEMBL2304157 92772 0 None - 0 Mouse 8.2 pIC50 = 8.2 Binding
The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the mouse cerebral cortex (CCK-B);value ranges from 5.3 to 7.7The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the mouse cerebral cortex (CCK-B);value ranges from 5.3 to 7.7
ChEMBL 681 13 6 8 3.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)Nc1nn[nH]n1)c1ccccc1 10.1016/S0960-894X(00)80652-6
5311201 214174 35 None -27 6 Human 8.2 pIC50 = 8.2 Binding
Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00001a027
CHEMBL9387 214174 35 None -27 6 Human 8.2 pIC50 = 8.2 Binding
Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00001a027
10484212 106655 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [125I]-Cholecystokinin-8 (125I-CCK-8) binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesInhibition of [125I]-Cholecystokinin-8 (125I-CCK-8) binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranes
ChEMBL 635 6 3 7 4.3 Cc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(-c3nn[nH]n3)c1)N=C2c1ccccc1F 10.1016/S0960-894X(96)00609-9
CHEMBL285921 106655 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [125I]-Cholecystokinin-8 (125I-CCK-8) binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesInhibition of [125I]-Cholecystokinin-8 (125I-CCK-8) binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranes
ChEMBL 635 6 3 7 4.3 Cc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(-c3nn[nH]n3)c1)N=C2c1ccccc1F 10.1016/S0960-894X(96)00609-9
9984452 172082 0 None - 0 Mouse 8.2 pIC50 = 8.2 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 529 9 4 4 4.7 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
CHEMBL423329 172082 0 None - 0 Mouse 8.2 pIC50 = 8.2 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 529 9 4 4 4.7 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
10475990 122776 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 398 3 2 3 4.0 Cc1ccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc1 10.1021/jm00078a018
CHEMBL33554 122776 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 398 3 2 3 4.0 Cc1ccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc1 10.1021/jm00078a018
44368633 53319 0 None - 0 Mouse 8.2 pIC50 = 8.2 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 588 12 5 5 4.3 C[C@@H]1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CNC(=O)/C=C/C(=O)O)Cc1ccccc1 10.1021/jm00057a005
CHEMBL153787 53319 0 None - 0 Mouse 8.2 pIC50 = 8.2 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 588 12 5 5 4.3 C[C@@H]1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CNC(=O)/C=C/C(=O)O)Cc1ccccc1 10.1021/jm00057a005
10577834 123522 0 None - 0 Mouse 8.2 pIC50 = 8.2 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 518 6 3 4 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NN1CC2CCC(CC2)C1 10.1021/jm970065l
CHEMBL337529 123522 0 None - 0 Mouse 8.2 pIC50 = 8.2 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 518 6 3 4 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NN1CC2CCC(CC2)C1 10.1021/jm970065l
15637206 85676 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
The compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligandThe compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligand
ChEMBL 428 4 3 4 3.3 CN1C(=O)[C@H](NC(=O)Nc2ccc(C(=O)O)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00032a003
CHEMBL2112932 85676 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
The compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligandThe compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligand
ChEMBL 428 4 3 4 3.3 CN1C(=O)[C@H](NC(=O)Nc2ccc(C(=O)O)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00032a003
44269000 39690 0 None - 0 Mouse 8.2 pIC50 = 8.2 Binding
Binding affinity towards Cholecystokinin type B receptor in mouse cortex membraneBinding affinity towards Cholecystokinin type B receptor in mouse cortex membrane
ChEMBL 671 14 6 5 6.3 Cc1ccccc1NC(=O)NCCCC[C@@H](CC(=O)O)NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1016/s0960-894x(00)00198-0
CHEMBL14153 39690 0 None - 0 Mouse 8.2 pIC50 = 8.2 Binding
Binding affinity towards Cholecystokinin type B receptor in mouse cortex membraneBinding affinity towards Cholecystokinin type B receptor in mouse cortex membrane
ChEMBL 671 14 6 5 6.3 Cc1ccccc1NC(=O)NCCCC[C@@H](CC(=O)O)NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1016/s0960-894x(00)00198-0
10099144 121319 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 552 5 3 3 6.0 CC(C)(C)NC(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](c2ccccc2)c2ccc(Cl)cc21 10.1021/jm00048a015
CHEMBL333671 121319 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 552 5 3 3 6.0 CC(C)(C)NC(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](c2ccccc2)c2ccc(Cl)cc21 10.1021/jm00048a015
44269000 39690 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
Inhibition of [3H]propionyl-CCK-8 specific binding to rat cerebral cortex membranes Cholecystokinin type B receptorInhibition of [3H]propionyl-CCK-8 specific binding to rat cerebral cortex membranes Cholecystokinin type B receptor
ChEMBL 671 14 6 5 6.3 Cc1ccccc1NC(=O)NCCCC[C@@H](CC(=O)O)NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1016/s0960-894x(01)00630-8
CHEMBL14153 39690 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
Inhibition of [3H]propionyl-CCK-8 specific binding to rat cerebral cortex membranes Cholecystokinin type B receptorInhibition of [3H]propionyl-CCK-8 specific binding to rat cerebral cortex membranes Cholecystokinin type B receptor
ChEMBL 671 14 6 5 6.3 Cc1ccccc1NC(=O)NCCCC[C@@H](CC(=O)O)NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1016/s0960-894x(01)00630-8
9853654 29561 41 None - 2 Rat 8.2 pIC50 = 8.2 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00079a003
CHEMBL1328 29561 41 None - 2 Rat 8.2 pIC50 = 8.2 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00079a003
10392523 214723 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 540 6 3 3 5.9 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)NC(C)(C)C)C2=O)c1 10.1016/S0960-894X(01)80832-5
CHEMBL96970 214723 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 540 6 3 3 5.9 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)NC(C)(C)C)C2=O)c1 10.1016/S0960-894X(01)80832-5
10075052 196453 0 None -10 2 Human 8.2 pIC50 = 8.2 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 510 3 2 3 4.3 CN1C(=O)[C@H](NC(=O)Nc2cccc(I)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL515268 196453 0 None -10 2 Human 8.2 pIC50 = 8.2 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 510 3 2 3 4.3 CN1C(=O)[C@H](NC(=O)Nc2cccc(I)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL515288 196453 0 None -10 2 Human 8.2 pIC50 = 8.2 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 510 3 2 3 4.3 CN1C(=O)[C@H](NC(=O)Nc2cccc(I)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
10409900 110635 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against Cholecystokinin type B receptor in guinea pig cerebral cortex using [125 I ]- CCK-8 as radioligand.Inhibitory activity against Cholecystokinin type B receptor in guinea pig cerebral cortex using [125 I ]- CCK-8 as radioligand.
ChEMBL 420 3 2 3 4.5 Cc1cccc(NC(=O)N[C@@H]2C[C@@H](N3CCCCCC3)c3ccccc3N(C)C2=O)c1 10.1016/0960-894X(95)00234-K
CHEMBL30919 110635 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against Cholecystokinin type B receptor in guinea pig cerebral cortex using [125 I ]- CCK-8 as radioligand.Inhibitory activity against Cholecystokinin type B receptor in guinea pig cerebral cortex using [125 I ]- CCK-8 as radioligand.
ChEMBL 420 3 2 3 4.5 Cc1cccc(NC(=O)N[C@@H]2C[C@@H](N3CCCCCC3)c3ccccc3N(C)C2=O)c1 10.1016/0960-894X(95)00234-K
44368382 52113 0 None - 0 Mouse 8.2 pIC50 = 8.2 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 511 9 4 4 4.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1CCCCC1Cl)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
CHEMBL152682 52113 0 None - 0 Mouse 8.2 pIC50 = 8.2 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 511 9 4 4 4.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1CCCCC1Cl)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
71452818 86489 0 None - 0 Mouse 7.2 pIC50 = 7.2 Binding
Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.
ChEMBL 541 9 4 4 5.3 O=C(O)C[C@@H](Cc1ccccc1)NC(=O)C(=Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1016/S0960-894X(00)80273-5
CHEMBL2115543 86489 0 None - 0 Mouse 7.2 pIC50 = 7.2 Binding
Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.
ChEMBL 541 9 4 4 5.3 O=C(O)C[C@@H](Cc1ccccc1)NC(=O)C(=Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1016/S0960-894X(00)80273-5
44280372 106163 0 None - 1 Human 7.2 pIC50 = 7.2 Binding
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 787 17 4 8 5.8 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL282645 106163 0 None - 1 Human 7.2 pIC50 = 7.2 Binding
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 787 17 4 8 5.8 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL287751 217645 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cellsBinding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cells
ChEMBL None None None CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00001a019
CHEMBL37900 219043 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cellsBinding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cells
ChEMBL None None None CCCS[C@H]1CCN(C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(C)=O)[C@@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00001a019
10816869 58627 0 None - 0 Mouse 6.2 pIC50 = 6.2 Binding
Compound was tested for the inhibition of specific binding of [125I]bolton Hunter CCK-8 to Cholecystokinin type B receptor in mouse cerebral cortexCompound was tested for the inhibition of specific binding of [125I]bolton Hunter CCK-8 to Cholecystokinin type B receptor in mouse cerebral cortex
ChEMBL 569 8 3 5 5.2 COC(=O)[C@]1(NC(=O)[C@@](C)(Cc2c[nH]c3ccccc23)NC(=O)OC2C3CC4CC(C3)CC2C4)C[C@H]1c1ccccc1 10.1016/S0960-894X(01)81250-6
CHEMBL158547 58627 0 None - 0 Mouse 6.2 pIC50 = 6.2 Binding
Compound was tested for the inhibition of specific binding of [125I]bolton Hunter CCK-8 to Cholecystokinin type B receptor in mouse cerebral cortexCompound was tested for the inhibition of specific binding of [125I]bolton Hunter CCK-8 to Cholecystokinin type B receptor in mouse cerebral cortex
ChEMBL 569 8 3 5 5.2 COC(=O)[C@]1(NC(=O)[C@@](C)(Cc2c[nH]c3ccccc23)NC(=O)OC2C3CC4CC(C3)CC2C4)C[C@H]1c1ccccc1 10.1016/S0960-894X(01)81250-6
44211354 19636 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortexDisplacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortex
ChEMBL 536 6 1 4 4.2 CN1CCN(C(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCCC3)CC2)CC1 10.1016/S0960-894X(00)80681-2
CHEMBL1188705 19636 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortexDisplacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortex
ChEMBL 536 6 1 4 4.2 CN1CCN(C(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCCC3)CC2)CC1 10.1016/S0960-894X(00)80681-2
CHEMBL537171 19636 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortexDisplacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortex
ChEMBL 536 6 1 4 4.2 CN1CCN(C(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCCC3)CC2)CC1 10.1016/S0960-894X(00)80681-2
44381489 103968 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranesIn vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranes
ChEMBL 1124 30 10 12 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80679-4
CHEMBL268337 103968 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranesIn vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranes
ChEMBL 1124 30 10 12 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80679-4
44349069 124837 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 455 7 3 4 3.6 O=C(O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)NN1CCC2(CCCC2)CC1 10.1021/jm00079a003
CHEMBL340413 124837 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 455 7 3 4 3.6 O=C(O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)NN1CCC2(CCCC2)CC1 10.1021/jm00079a003
44280115 114004 0 None - 0 Mouse 6.2 pIC50 = 6.2 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 658 11 3 6 5.8 CN1C(=O)[C@H](NC(=O)Nc2cccc(C(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
CHEMBL31671 114004 0 None - 0 Mouse 6.2 pIC50 = 6.2 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 658 11 3 6 5.8 CN1C(=O)[C@H](NC(=O)Nc2cccc(C(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
9853654 29561 41 None 31 2 Human 5.2 pIC50 = 5.2 Binding
Concentration required to inhibit by 50% the specific binding of [3H]pentagastrin to cholecystokinin type B receptor in rabbit gastric glandConcentration required to inhibit by 50% the specific binding of [3H]pentagastrin to cholecystokinin type B receptor in rabbit gastric gland
ChEMBL 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00079a003
CHEMBL1328 29561 41 None 31 2 Human 5.2 pIC50 = 5.2 Binding
Concentration required to inhibit by 50% the specific binding of [3H]pentagastrin to cholecystokinin type B receptor in rabbit gastric glandConcentration required to inhibit by 50% the specific binding of [3H]pentagastrin to cholecystokinin type B receptor in rabbit gastric gland
ChEMBL 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00079a003
44375216 63314 0 None - 0 Mouse 5.2 pIC50 = 5.2 Binding
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 596 13 5 7 3.8 O=C(O)CN(CCc1ccccc1)S(=O)(=O)c1ccc(N/N=C(/S)NCCc2c[nH]c3ccccc23)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
CHEMBL163816 63314 0 None - 0 Mouse 5.2 pIC50 = 5.2 Binding
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 596 13 5 7 3.8 O=C(O)CN(CCc1ccccc1)S(=O)(=O)c1ccc(N/N=C(/S)NCCc2c[nH]c3ccccc23)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
44375424 126921 0 None - 0 Mouse 5.2 pIC50 = 5.2 Binding
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 610 14 5 7 4.2 O=C(O)CN(CCCc1ccccc1)S(=O)(=O)c1ccc(N/N=C(/S)NCCc2c[nH]c3ccccc23)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
CHEMBL351310 126921 0 None - 0 Mouse 5.2 pIC50 = 5.2 Binding
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 610 14 5 7 4.2 O=C(O)CN(CCCc1ccccc1)S(=O)(=O)c1ccc(N/N=C(/S)NCCc2c[nH]c3ccccc23)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
44377589 126936 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.
ChEMBL 635 15 6 6 3.8 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(=O)O)NC(=O)CCc1ccccc1 10.1021/jm00388a002
CHEMBL351506 126936 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.
ChEMBL 635 15 6 6 3.8 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(=O)O)NC(=O)CCc1ccccc1 10.1021/jm00388a002
44349101 23616 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 468 7 3 3 5.0 O=C(O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)NC1CCC2(CCCCC2)CC1 10.1021/jm00079a003
CHEMBL124805 23616 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 468 7 3 3 5.0 O=C(O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)NC1CCC2(CCCCC2)CC1 10.1021/jm00079a003
13953698 108686 0 None - 0 Human 4.2 pIC50 = 4.2 Binding
Displacement of [125I]gastrin from guinea pig gastric glandsDisplacement of [125I]gastrin from guinea pig gastric glands
ChEMBL 464 5 1 5 5.1 CN(C)Cc1nnc2n1-c1ccccc1C(c1ccccc1F)=N[C@@H]2Cc1c[nH]c2ccccc12 10.1021/jm00396a028
CHEMBL300926 108686 0 None - 0 Human 4.2 pIC50 = 4.2 Binding
Displacement of [125I]gastrin from guinea pig gastric glandsDisplacement of [125I]gastrin from guinea pig gastric glands
ChEMBL 464 5 1 5 5.1 CN(C)Cc1nnc2n1-c1ccccc1C(c1ccccc1F)=N[C@@H]2Cc1c[nH]c2ccccc12 10.1021/jm00396a028
14208273 74512 0 None - 0 Human 4.2 pIC50 = 4.2 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 457 7 1 3 5.1 CCCCCc1ccc(C(=O)N[C@H]2N=C(c3ccccc3F)c3ccccc3N(C)C2=O)cc1 10.1021/jm00120a002
CHEMBL1907840 74512 0 None - 0 Human 4.2 pIC50 = 4.2 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 457 7 1 3 5.1 CCCCCc1ccc(C(=O)N[C@H]2N=C(c3ccccc3F)c3ccccc3N(C)C2=O)cc1 10.1021/jm00120a002
155517761 177002 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1900 71 16 23 4.4 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1cccc2ccccc12)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4445529 177002 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1900 71 16 23 4.4 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1cccc2ccccc12)C(N)=O 10.1021/acs.jmedchem.8b01558
10507071 120387 0 None - 1 Human 5.2 pIC50 = 5.2 Binding
Inhibition of CCK binding to Cos-7 cells expressing human cholecystokinin 2 receptorInhibition of CCK binding to Cos-7 cells expressing human cholecystokinin 2 receptor
ChEMBL 559 7 3 5 4.1 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@@H]12 10.1021/jm0501127
CHEMBL332261 120387 0 None - 1 Human 5.2 pIC50 = 5.2 Binding
Inhibition of CCK binding to Cos-7 cells expressing human cholecystokinin 2 receptorInhibition of CCK binding to Cos-7 cells expressing human cholecystokinin 2 receptor
ChEMBL 559 7 3 5 4.1 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@@H]12 10.1021/jm0501127
10002123 85586 1 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 418 3 2 3 4.3 CN1C(=O)[C@H](NC(=O)Nc2ccccc2Cl)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL2112748 85586 1 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 418 3 2 3 4.3 CN1C(=O)[C@H](NC(=O)Nc2ccccc2Cl)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
44280316 103539 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 680 11 4 5 5.8 O=C(C[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O)Nc1cccc2ccccc12 10.1021/jm950372w
CHEMBL264606 103539 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 680 11 4 5 5.8 O=C(C[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O)Nc1cccc2ccccc12 10.1021/jm950372w
44210426 65892 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 449 4 2 4 2.2 Cc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)N3CCN(C)CC3)C2=O)c1 10.1016/S0960-894X(00)80683-6
CHEMBL169807 65892 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 449 4 2 4 2.2 Cc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)N3CCN(C)CC3)C2=O)c1 10.1016/S0960-894X(00)80683-6
10011110 168108 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL 948 24 8 7 5.7 Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(c1ccccc1)c1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
CHEMBL412544 168108 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL 948 24 8 7 5.7 Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(c1ccccc1)c1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
CHEMBL106722 215251 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL None None None Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
14991536 113604 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 841 22 9 9 2.9 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL3144567 113604 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 841 22 9 9 2.9 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL170026 215619 0 None - 0 Mouse 4.2 pIC50 = 4.2 Binding
Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N1C[C@H](Cc2ccccc2)NC(=O)[C@@H]1CC(=O)O 10.1016/S0960-894X(01)80253-5
10744084 213931 0 None - 0 Mouse 6.2 pIC50 = 6.2 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 503 8 3 9 3.7 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2ccc(OC)c(OC)c2)c1 10.1021/jm970373j
CHEMBL9230 213931 0 None - 0 Mouse 6.2 pIC50 = 6.2 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 503 8 3 9 3.7 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2ccc(OC)c(OC)c2)c1 10.1021/jm970373j
44279853 111570 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 593 10 3 4 5.6 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](CC1CCCCC1)C(=O)O 10.1021/jm950372w
CHEMBL31093 111570 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 593 10 3 4 5.6 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](CC1CCCCC1)C(=O)O 10.1021/jm950372w
10507071 120387 0 None - 1 Rat 5.2 pIC50 = 5.2 Binding
Binding affinity by competitive inhibition of the radioligand [3H]pCCK-8 at Cholecystokinin type B receptor from rat cerebral cortex membraneBinding affinity by competitive inhibition of the radioligand [3H]pCCK-8 at Cholecystokinin type B receptor from rat cerebral cortex membrane
ChEMBL 559 7 3 5 4.1 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@@H]12 10.1021/jm991078x
CHEMBL332261 120387 0 None - 1 Rat 5.2 pIC50 = 5.2 Binding
Binding affinity by competitive inhibition of the radioligand [3H]pCCK-8 at Cholecystokinin type B receptor from rat cerebral cortex membraneBinding affinity by competitive inhibition of the radioligand [3H]pCCK-8 at Cholecystokinin type B receptor from rat cerebral cortex membrane
ChEMBL 559 7 3 5 4.1 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@@H]12 10.1021/jm991078x
44396744 130824 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
Inhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenatesInhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenates
ChEMBL 516 7 2 5 4.4 CC(C)(C)OC(=O)[C@H](Cc1c[nH]c2ccccc12)N[C@@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)CC12 10.1021/jm0498755
CHEMBL363106 130824 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
Inhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenatesInhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenates
ChEMBL 516 7 2 5 4.4 CC(C)(C)OC(=O)[C@H](Cc1c[nH]c2ccccc12)N[C@@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)CC12 10.1021/jm0498755
10626665 17033 0 None - 1 Rat 5.2 pIC50 = 5.2 Binding
Inhibition of [3H]pCCK-8 binding to cholecystokinin type B receptor of rat cerebral cortexInhibition of [3H]pCCK-8 binding to cholecystokinin type B receptor of rat cerebral cortex
ChEMBL 559 7 3 5 4.1 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@H]12 10.1021/jm010898i
CHEMBL116127 17033 0 None - 1 Rat 5.2 pIC50 = 5.2 Binding
Inhibition of [3H]pCCK-8 binding to cholecystokinin type B receptor of rat cerebral cortexInhibition of [3H]pCCK-8 binding to cholecystokinin type B receptor of rat cerebral cortex
ChEMBL 559 7 3 5 4.1 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@H]12 10.1021/jm010898i
10626665 17033 0 None - 1 Rat 5.2 pIC50 = 5.2 Binding
Inhibition of [3H]pCCK-8 specific binding cholecystokinin type B receptor in rat cerebral cortex membranesInhibition of [3H]pCCK-8 specific binding cholecystokinin type B receptor in rat cerebral cortex membranes
ChEMBL 559 7 3 5 4.1 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@H]12 10.1021/jm010813d
CHEMBL116127 17033 0 None - 1 Rat 5.2 pIC50 = 5.2 Binding
Inhibition of [3H]pCCK-8 specific binding cholecystokinin type B receptor in rat cerebral cortex membranesInhibition of [3H]pCCK-8 specific binding cholecystokinin type B receptor in rat cerebral cortex membranes
ChEMBL 559 7 3 5 4.1 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@H]12 10.1021/jm010813d
CHEMBL385727 219140 0 None - 0 Bovine 5.2 pIC50 = 5.2 Binding
Concentration inhibiting [3H]propionyl-CCK-8 binding to cholecystokinin type B receptor of bovine striatum.Concentration inhibiting [3H]propionyl-CCK-8 binding to cholecystokinin type B receptor of bovine striatum.
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N1CSC(C)(C)[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00100a033
14888722 84023 0 None - 0 Bovine 7.2 pIC50 = 7.2 Binding
Inhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranesInhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranes
ChEMBL 1055 30 11 14 -0.2 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@@H](Cc1ccc(Cc2nnn[nH]2)cc1)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00107a037
CHEMBL2079601 84023 0 None - 0 Bovine 7.2 pIC50 = 7.2 Binding
Inhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranesInhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranes
ChEMBL 1055 30 11 14 -0.2 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@@H](Cc1ccc(Cc2nnn[nH]2)cc1)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00107a037
CHEMBL2079548 215970 0 None - 0 Bovine 7.2 pIC50 = 7.2 Binding
Inhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranesInhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccc(C(=O)O)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00107a037
44280245 106811 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 708 12 3 5 6.2 CN(C(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)c1cccc2ccccc12 10.1021/jm950372w
CHEMBL286941 106811 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 708 12 3 5 6.2 CN(C(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)c1cccc2ccccc12 10.1021/jm950372w
CHEMBL2370120 216565 0 None - 0 Bovine 6.2 pIC50 = 6.2 Binding
Inhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranesInhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranes
ChEMBL None None None CSCC[C@@H](NC(=O)[C@H](Cc1ccc(CCC(=O)O)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00107a037
14208312 84597 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 437 3 1 3 4.3 CN1C(=O)[C@@H](NC(=O)c2ccc(C(F)(F)F)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
CHEMBL2092865 84597 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 437 3 1 3 4.3 CN1C(=O)[C@@H](NC(=O)c2ccc(C(F)(F)F)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
44381513 175473 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
In vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic aciniIn vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic acini
ChEMBL 1139 31 10 12 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NC(Cc1ccccc1)Cc1ccccc1 10.1016/S0960-894X(00)80679-4
CHEMBL436690 175473 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
In vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic aciniIn vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic acini
ChEMBL 1139 31 10 12 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NC(Cc1ccccc1)Cc1ccccc1 10.1016/S0960-894X(00)80679-4
44349324 23445 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 455 7 3 4 3.4 O=C(O)CCC(NC(=O)c1cccc(C(F)(F)F)c1)C(=O)NN1CCC2(CCCC2)CC1 10.1021/jm00079a003
CHEMBL124261 23445 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 455 7 3 4 3.4 O=C(O)CCC(NC(=O)c1cccc(C(F)(F)F)c1)C(=O)NN1CCC2(CCCC2)CC1 10.1021/jm00079a003
10693825 213835 0 None - 0 Mouse 7.2 pIC50 = 7.2 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 428 5 3 6 3.9 Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(N(C)C)c2)c1 10.1021/jm970373j
CHEMBL9171 213835 0 None - 0 Mouse 7.2 pIC50 = 7.2 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 428 5 3 6 3.9 Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(N(C)C)c2)c1 10.1021/jm970373j
44354125 29923 0 None - 0 Mouse 7.2 pIC50 = 7.2 Binding
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 628 13 5 5 5.2 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCC[C@H](NC(=O)CCC(=O)O)c1ccccc1 10.1021/jm00105a062
CHEMBL133101 29923 0 None - 0 Mouse 7.2 pIC50 = 7.2 Binding
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 628 13 5 5 5.2 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCC[C@H](NC(=O)CCC(=O)O)c1ccccc1 10.1021/jm00105a062
14802539 83327 1 None - 1 Mouse 7.2 pIC50 = 7.2 Binding
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 614 12 5 5 4.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1 10.1016/S0960-894X(00)80685-X
CHEMBL2062144 83327 1 None - 1 Mouse 7.2 pIC50 = 7.2 Binding
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 614 12 5 5 4.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1 10.1016/S0960-894X(00)80685-X
44280414 108636 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 708 13 4 5 5.9 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NCc1cccc2ccccc12 10.1021/jm950372w
CHEMBL30061 108636 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 708 13 4 5 5.9 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NCc1cccc2ccccc12 10.1021/jm950372w
44280388 123647 0 None - 1 Human 7.2 pIC50 = 7.2 Binding
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 759 15 4 8 5.0 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL33819 123647 0 None - 1 Human 7.2 pIC50 = 7.2 Binding
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 759 15 4 8 5.0 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
11613212 78876 0 None - 3 Dog 7.2 pIC50 = 7.2 Binding
Concentration required to inhibit the binding of [125I]-BH-CCK-8S radioligand to canine gastric mucosa CCK2 receptorConcentration required to inhibit the binding of [125I]-BH-CCK-8S radioligand to canine gastric mucosa CCK2 receptor
ChEMBL 513 7 3 4 6.4 Cc1cc(C)c(-c2nc(C(=O)Nc3cccc(C(=O)O)c3)c(COC34CC5CC(CC(C5)C3)C4)[nH]2)c(C)c1 10.1021/jm0490686
CHEMBL197780 78876 0 None - 3 Dog 7.2 pIC50 = 7.2 Binding
Concentration required to inhibit the binding of [125I]-BH-CCK-8S radioligand to canine gastric mucosa CCK2 receptorConcentration required to inhibit the binding of [125I]-BH-CCK-8S radioligand to canine gastric mucosa CCK2 receptor
ChEMBL 513 7 3 4 6.4 Cc1cc(C)c(-c2nc(C(=O)Nc3cccc(C(=O)O)c3)c(COC34CC5CC(CC(C5)C3)C4)[nH]2)c(C)c1 10.1021/jm0490686
CHEMBL1171596 215358 0 None - 1 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2010.05.078
14208236 211460 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 426 3 2 4 3.9 Cn1c(C(=O)NC2N=C(c3ccccc3F)c3ccccc3NC2=O)cc2ccccc21 10.1021/jm00120a002
CHEMBL73885 211460 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 426 3 2 4 3.9 Cn1c(C(=O)NC2N=C(c3ccccc3F)c3ccccc3NC2=O)cc2ccccc21 10.1021/jm00120a002
23129945 16382 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 604 16 2 4 7.8 CCCCCN(CCCCC)C(=O)C(Cc1c[nH]c2ccc(OCc3ccccc3)cc12)NC(=O)c1cnc2ccccc2c1 10.1021/jm00116a002
CHEMBL112612 16382 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 604 16 2 4 7.8 CCCCCN(CCCCC)C(=O)C(Cc1c[nH]c2ccc(OCc3ccccc3)cc12)NC(=O)c1cnc2ccccc2c1 10.1021/jm00116a002
44306868 108860 0 None - 1 Human 4.2 pIC50 = 4.2 Binding
Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes
ChEMBL 836 18 9 7 3.7 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NC(Cc1ccc(NC(=O)Nc2ccccc2Cl)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccc(C)cc1)C(N)=O 10.1021/jm00001a027
CHEMBL302150 108860 0 None - 1 Human 4.2 pIC50 = 4.2 Binding
Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes
ChEMBL 836 18 9 7 3.7 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NC(Cc1ccc(NC(=O)Nc2ccccc2Cl)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccc(C)cc1)C(N)=O 10.1021/jm00001a027
10000984 123421 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 399 3 2 4 3.4 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3cnccc3N(C)C2=O)c1 10.1021/jm00078a018
CHEMBL336972 123421 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 399 3 2 4 3.4 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3cnccc3N(C)C2=O)c1 10.1021/jm00078a018
44281020 123422 0 None - 1 Mouse 7.2 pIC50 = 7.2 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 773 16 4 8 6.2 CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
CHEMBL33698 123422 0 None - 1 Mouse 7.2 pIC50 = 7.2 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 773 16 4 8 6.2 CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
44327458 214636 0 None - 0 Mouse 7.2 pIC50 = 7.2 Binding
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 571 11 3 4 5.6 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCC(=O)O)CCc1ccccc1 10.1016/S0960-894X(01)80769-1
CHEMBL96469 214636 0 None - 0 Mouse 7.2 pIC50 = 7.2 Binding
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 571 11 3 4 5.6 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCC(=O)O)CCc1ccccc1 10.1016/S0960-894X(01)80769-1
10432393 107122 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 422 3 3 3 4.4 O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2F)c2ccccc2NC1=O 10.1021/jm00121a004
CHEMBL289533 107122 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 422 3 3 3 4.4 O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2F)c2ccccc2NC1=O 10.1021/jm00121a004
10323690 107274 0 None - 2 Mouse 6.2 pIC50 = 6.2 Binding
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 499 8 3 3 5.4 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccc1 10.1021/jm00086a017
CHEMBL2114401 107274 0 None - 2 Mouse 6.2 pIC50 = 6.2 Binding
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 499 8 3 3 5.4 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccc1 10.1021/jm00086a017
CHEMBL291033 107274 0 None - 2 Mouse 6.2 pIC50 = 6.2 Binding
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 499 8 3 3 5.4 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccc1 10.1021/jm00086a017
10418081 117149 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL 840 23 9 8 2.4 Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
CHEMBL324219 117149 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL 840 23 9 8 2.4 Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
CHEMBL319438 217996 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL None None None CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
14208274 176071 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 443 3 1 3 4.7 CN1C(=O)C(NC(=O)c2ccc(C(C)(C)C)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL441445 176071 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 443 3 1 3 4.7 CN1C(=O)C(NC(=O)c2ccc(C(C)(C)C)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL169054 215614 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Compound was tested for its inhibitory activity in cortical cholecystokinin type B receptor in guinea pigCompound was tested for its inhibitory activity in cortical cholecystokinin type B receptor in guinea pig
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00105a068
13822922 195859 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]gastrin from guinea pig gastric glandsDisplacement of [125I]gastrin from guinea pig gastric glands
ChEMBL 436 3 2 5 4.2 O=C(NC1N=C(c2ccccc2F)c2ccccc2-n2cnnc21)c1cc2ccccc2[nH]1 10.1021/jm00396a028
CHEMBL50986 195859 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]gastrin from guinea pig gastric glandsDisplacement of [125I]gastrin from guinea pig gastric glands
ChEMBL 436 3 2 5 4.2 O=C(NC1N=C(c2ccccc2F)c2ccccc2-n2cnnc21)c1cc2ccccc2[nH]1 10.1021/jm00396a028
73349806 103217 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat TcellsInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat Tcells
ChEMBL 1019 29 9 11 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCOc1ccccc1)CC(=O)O 10.1021/jm00072a024
CHEMBL262155 103217 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat TcellsInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat Tcells
ChEMBL 1019 29 9 11 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCOc1ccccc1)CC(=O)O 10.1021/jm00072a024
44329287 214414 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 544 6 3 3 5.7 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccc(F)cc3)C[C@H](c3ccccc3)N(CC(=O)NC(C)(C)C)C2=O)c1 10.1016/S0960-894X(01)80832-5
CHEMBL95209 214414 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 544 6 3 3 5.7 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccc(F)cc3)C[C@H](c3ccccc3)N(CC(=O)NC(C)(C)C)C2=O)c1 10.1016/S0960-894X(01)80832-5
CHEMBL169054 215614 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Tested for the inhibition of specific [3H]propionyl-CCK-8 binding to guinea pig pancreatic Cholecystokinin type B receptorTested for the inhibition of specific [3H]propionyl-CCK-8 binding to guinea pig pancreatic Cholecystokinin type B receptor
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(97)00107-8
10553685 125929 0 None - 0 Mouse 7.2 pIC50 = 7.2 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 508 8 3 5 4.2 COC[C@@H]1CCCN1NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1021/jm970065l
CHEMBL342907 125929 0 None - 0 Mouse 7.2 pIC50 = 7.2 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 508 8 3 5 4.2 COC[C@@H]1CCCN1NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1021/jm970065l
19766160 65283 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 456 4 2 3 3.9 O=C(Nc1cccc2ccccc12)NC1CCc2ccccc2N(CC(=O)N2CCCC2)C1=O 10.1016/S0960-894X(00)80683-6
CHEMBL168386 65283 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 456 4 2 3 3.9 O=C(Nc1cccc2ccccc12)NC1CCc2ccccc2N(CC(=O)N2CCCC2)C1=O 10.1016/S0960-894X(00)80683-6
14208232 210918 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 452 5 3 4 3.2 O=C(O)CN1C(=O)C(NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
CHEMBL70456 210918 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 452 5 3 4 3.2 O=C(O)CN1C(=O)C(NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
CHEMBL2111881 215999 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Binding affinity towards Cholecystokinin type B receptor was determined in guinea pig cortex using [3H]SNF8702 as radioligandBinding affinity towards Cholecystokinin type B receptor was determined in guinea pig cortex using [3H]SNF8702 as radioligand
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)[C@H](C)c1c[nH]c2ccccc12 10.1021/jm960078j
CHEMBL2111882 216000 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Binding affinity towards Cholecystokinin type B receptor was determined in guinea pig cortex using [3H]SNF8702 as radioligandBinding affinity towards Cholecystokinin type B receptor was determined in guinea pig cortex using [3H]SNF8702 as radioligand
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)[C@@H](C)c1c[nH]c2ccccc12 10.1021/jm960078j
10485763 116453 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL 860 21 8 8 4.2 Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)Oc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
CHEMBL322635 116453 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL 860 21 8 8 4.2 Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)Oc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
44379627 64906 0 None - 0 Mouse 6.2 pIC50 = 6.2 Binding
Inhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 520 7 2 5 4.9 CC(C)Oc1cccc(-n2c(CNC(=O)NCc3ccc(Br)cc3)nc3ccccc3c2=O)c1 10.1016/S0960-894X(97)00108-X
CHEMBL167758 64906 0 None - 0 Mouse 6.2 pIC50 = 6.2 Binding
Inhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 520 7 2 5 4.9 CC(C)Oc1cccc(-n2c(CNC(=O)NCc3ccc(Br)cc3)nc3ccccc3c2=O)c1 10.1016/S0960-894X(97)00108-X
44280246 108941 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 694 12 4 5 6.2 O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1ccc2ccccc2c1 10.1021/jm950372w
CHEMBL30262 108941 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 694 12 4 5 6.2 O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1ccc2ccccc2c1 10.1021/jm950372w
44280510 109732 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 621 10 3 4 5.5 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(Cc1ccc(Cl)cc1)C(=O)O 10.1021/jm950372w
CHEMBL30639 109732 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 621 10 3 4 5.5 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(Cc1ccc(Cl)cc1)C(=O)O 10.1021/jm950372w
10341040 123387 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 402 3 2 3 3.8 CN1C(=O)C(NC(=O)Nc2ccc(F)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL336749 123387 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 402 3 2 3 3.8 CN1C(=O)C(NC(=O)Nc2ccc(F)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
10363545 212520 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 399 3 2 4 3.4 Cc1cccc(NC(=O)NC2N=C(c3ccccn3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
CHEMBL82685 212520 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 399 3 2 4 3.4 Cc1cccc(NC(=O)NC2N=C(c3ccccn3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
10363545 212520 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 399 3 2 4 3.4 Cc1cccc(NC(=O)NC2N=C(c3ccccn3)c3ccccc3N(C)C2=O)c1 10.1021/jm9608523
CHEMBL82685 212520 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 399 3 2 4 3.4 Cc1cccc(NC(=O)NC2N=C(c3ccccn3)c3ccccc3N(C)C2=O)c1 10.1021/jm9608523
44329286 113982 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 540 6 3 3 5.9 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3cccc(C)c3)C[C@H](c3ccccc3)N(CC(=O)NC(C)(C)C)C2=O)c1 10.1016/S0960-894X(01)80832-5
CHEMBL316619 113982 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 540 6 3 3 5.9 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3cccc(C)c3)C[C@H](c3ccccc3)N(CC(=O)NC(C)(C)C)C2=O)c1 10.1016/S0960-894X(01)80832-5
155568312 182857 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1836 72 17 23 3.0 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4591101 182857 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1836 72 17 23 3.0 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
44280713 106808 0 None - 1 Mouse 5.2 pIC50 = 5.2 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 740 15 6 9 3.6 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCCC(=O)NCCSCc3csc(N=C(N)N)n3)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL286907 106808 0 None - 1 Mouse 5.2 pIC50 = 5.2 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 740 15 6 9 3.6 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCCC(=O)NCCSCc3csc(N=C(N)N)n3)C2=O)c1 10.1016/S0960-894X(96)00248-X
155543163 180065 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1886 72 16 25 2.5 CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4525615 180065 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1886 72 16 25 2.5 CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
14843040 106918 1 None - 0 Mouse 7.2 pIC50 = 7.2 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 527 6 1 4 6.7 O=c1c2ccccc2nc(CCc2c[nH]c3ccc(Br)cc23)n1-c1cccc(OC2CCCC2)c1 10.1021/jm00108a040
CHEMBL287740 106918 1 None - 0 Mouse 7.2 pIC50 = 7.2 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 527 6 1 4 6.7 O=c1c2ccccc2nc(CCc2c[nH]c3ccc(Br)cc23)n1-c1cccc(OC2CCCC2)c1 10.1021/jm00108a040
14843035 146605 0 None - 0 Mouse 7.2 pIC50 = 7.2 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 425 6 1 5 4.7 COc1cccc(-n2c(CCc3c[nH]c4ccc(OC)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
CHEMBL37990 146605 0 None - 0 Mouse 7.2 pIC50 = 7.2 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 425 6 1 5 4.7 COc1cccc(-n2c(CCc3c[nH]c4ccc(OC)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
10479056 32958 13 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 452 3 2 3 5.0 CN1C(=O)C(NC(=O)Nc2ccc(Cl)c(Cl)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL135702 32958 13 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 452 3 2 3 5.0 CN1C(=O)C(NC(=O)Nc2ccc(Cl)c(Cl)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
44279939 106093 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 637 10 3 4 6.0 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](Cc1cccc2ccccc12)C(=O)O 10.1021/jm950372w
CHEMBL282149 106093 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 637 10 3 4 6.0 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](Cc1cccc2ccccc12)C(=O)O 10.1021/jm950372w
14843023 144828 0 None - 0 Mouse 6.2 pIC50 = 6.2 Binding
Evaluated for inhibition of [125I]CCK-8S binding to cholecystokinin CCK-B receptor from mouse brain membranes at a concentration of 10 uM (in vitro)Evaluated for inhibition of [125I]CCK-8S binding to cholecystokinin CCK-B receptor from mouse brain membranes at a concentration of 10 uM (in vitro)
ChEMBL 365 4 1 3 4.7 O=c1c2ccccc2nc(CCc2c[nH]c3ccccc23)n1-c1ccccc1 10.1021/jm00092a003
CHEMBL37653 144828 0 None - 0 Mouse 6.2 pIC50 = 6.2 Binding
Evaluated for inhibition of [125I]CCK-8S binding to cholecystokinin CCK-B receptor from mouse brain membranes at a concentration of 10 uM (in vitro)Evaluated for inhibition of [125I]CCK-8S binding to cholecystokinin CCK-B receptor from mouse brain membranes at a concentration of 10 uM (in vitro)
ChEMBL 365 4 1 3 4.7 O=c1c2ccccc2nc(CCc2c[nH]c3ccccc23)n1-c1ccccc1 10.1021/jm00092a003
14843023 144828 0 None - 0 Mouse 6.2 pIC50 = 6.2 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 365 4 1 3 4.7 O=c1c2ccccc2nc(CCc2c[nH]c3ccccc23)n1-c1ccccc1 10.1021/jm00108a040
CHEMBL37653 144828 0 None - 0 Mouse 6.2 pIC50 = 6.2 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 365 4 1 3 4.7 O=c1c2ccccc2nc(CCc2c[nH]c3ccccc23)n1-c1ccccc1 10.1021/jm00108a040
136046102 107453 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 864 20 9 10 3.1 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1cnc2cccc(O)c2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL292298 107453 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 864 20 9 10 3.1 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1cnc2cccc(O)c2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
14208243 211196 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 403 3 1 3 3.9 CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
CHEMBL72073 211196 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 403 3 1 3 3.9 CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
14208243 211196 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Tested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pigTested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pig
ChEMBL 403 3 1 3 3.9 CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80682-4
CHEMBL72073 211196 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Tested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pigTested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pig
ChEMBL 403 3 1 3 3.9 CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80682-4
19754257 127155 1 None - 0 Human 4.2 pIC50 = 4.2 Binding
Tested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brainTested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL 340 3 3 2 4.3 O=C(Cc1c[nH]c2ccccc12)Nc1cc2c3ccccc3nc-2c[nH]1 10.1016/S0960-894X(00)80682-4
CHEMBL353304 127155 1 None - 0 Human 4.2 pIC50 = 4.2 Binding
Tested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brainTested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL 340 3 3 2 4.3 O=C(Cc1c[nH]c2ccccc12)Nc1cc2c3ccccc3nc-2c[nH]1 10.1016/S0960-894X(00)80682-4
44280406 126304 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 658 12 3 5 5.1 CN(C(=O)[C@@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)c1ccccc1 10.1021/jm950372w
CHEMBL34569 126304 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 658 12 3 5 5.1 CN(C(=O)[C@@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)c1ccccc1 10.1021/jm950372w
44303650 107556 0 None - 0 Mouse 5.2 pIC50 = 5.2 Binding
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 548 6 2 3 6.4 O=C(NC1(C(=O)NCCc2ccccc2)CC2(Cc3cccc4cccc(c34)C2)C1)OC1C2CC3CC(C2)CC1C3 10.1016/S0960-894X(97)00356-9
CHEMBL292956 107556 0 None - 0 Mouse 5.2 pIC50 = 5.2 Binding
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 548 6 2 3 6.4 O=C(NC1(C(=O)NCCc2ccccc2)CC2(Cc3cccc4cccc(c34)C2)C1)OC1C2CC3CC(C2)CC1C3 10.1016/S0960-894X(97)00356-9
14888706 84026 0 None - 0 Bovine 7.2 pIC50 = 7.2 Binding
Inhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranesInhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranes
ChEMBL 1017 29 11 12 0.4 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@@H](Cc1ccc(C(=O)O)cc1)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00107a037
CHEMBL2079604 84026 0 None - 0 Bovine 7.2 pIC50 = 7.2 Binding
Inhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranesInhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranes
ChEMBL 1017 29 11 12 0.4 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@@H](Cc1ccc(C(=O)O)cc1)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00107a037
44303238 170016 0 None - 0 Mouse 7.2 pIC50 = 7.2 Binding
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 536 10 4 6 3.8 COc1ccc(CC(C)(NC(=O)OC2C3CC4CC(C3)CC2C4)C(=O)N[C@H](CO)[C@H](O)c2ccccc2)cc1 10.1016/S0960-894X(97)00356-9
CHEMBL418464 170016 0 None - 0 Mouse 7.2 pIC50 = 7.2 Binding
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 536 10 4 6 3.8 COc1ccc(CC(C)(NC(=O)OC2C3CC4CC(C3)CC2C4)C(=O)N[C@H](CO)[C@H](O)c2ccccc2)cc1 10.1016/S0960-894X(97)00356-9
14208295 74523 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 465 3 1 3 4.2 CN1C(=O)[C@@H](NC(=O)c2ccc(Br)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL1907850 74523 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 465 3 1 3 4.2 CN1C(=O)[C@@H](NC(=O)c2ccc(Br)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
44279808 105917 0 None - 1 Mouse 5.2 pIC50 = 5.2 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 712 13 6 9 2.9 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCC(=O)NCCSCc3csc(N=C(N)N)n3)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL281082 105917 0 None - 1 Mouse 5.2 pIC50 = 5.2 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 712 13 6 9 2.9 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCC(=O)NCCSCc3csc(N=C(N)N)n3)C2=O)c1 10.1016/S0960-894X(96)00248-X
44209154 65868 1 None - 0 Human 4.2 pIC50 = 4.2 Binding
Tested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brainTested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL 315 4 2 2 4.2 O=C(CCc1ccccc1)Nc1cc2c3ccccc3nc-2c[nH]1 10.1016/S0960-894X(00)80682-4
CHEMBL169675 65868 1 None - 0 Human 4.2 pIC50 = 4.2 Binding
Tested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brainTested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL 315 4 2 2 4.2 O=C(CCc1ccccc1)Nc1cc2c3ccccc3nc-2c[nH]1 10.1016/S0960-894X(00)80682-4
14208242 163202 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 493 6 1 5 4.0 CCOC(=O)CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00121a004
CHEMBL40668 163202 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 493 6 1 5 4.0 CCOC(=O)CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00121a004
14208242 163202 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 493 6 1 5 4.0 CCOC(=O)CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL40668 163202 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 493 6 1 5 4.0 CCOC(=O)CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
14843028 125537 6 None - 0 Mouse 6.2 pIC50 = 6.2 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 399 4 1 3 5.3 O=c1c2ccccc2nc(CCc2c[nH]c3ccccc23)n1-c1cccc(Cl)c1 10.1021/jm00108a040
CHEMBL34185 125537 6 None - 0 Mouse 6.2 pIC50 = 6.2 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 399 4 1 3 5.3 O=c1c2ccccc2nc(CCc2c[nH]c3ccccc23)n1-c1cccc(Cl)c1 10.1021/jm00108a040
44379965 64612 0 None - 0 Mouse 6.2 pIC50 = 6.2 Binding
Inhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 496 6 2 5 5.5 CC(C)Oc1cccc(-n2c(CNC(=O)Nc3ccc(C(F)(F)F)cc3)nc3ccccc3c2=O)c1 10.1016/S0960-894X(97)00108-X
CHEMBL167169 64612 0 None - 0 Mouse 6.2 pIC50 = 6.2 Binding
Inhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 496 6 2 5 5.5 CC(C)Oc1cccc(-n2c(CNC(=O)Nc3ccc(C(F)(F)F)cc3)nc3ccccc3c2=O)c1 10.1016/S0960-894X(97)00108-X
44280993 125115 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 678 12 4 5 5.5 CC1(C)CCC(NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCC3)CC2)CC1 10.1021/jm950372w
CHEMBL34101 125115 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 678 12 4 5 5.5 CC1(C)CCC(NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCC3)CC2)CC1 10.1021/jm950372w
46235271 80423 2 None -2 2 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I-CCK] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-CCK] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 649 7 1 6 6.7 Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 10.1021/acs.jmedchem.5b01110
CHEMBL2017835 80423 2 None -2 2 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I-CCK] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-CCK] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 649 7 1 6 6.7 Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 10.1021/acs.jmedchem.5b01110
10769902 213324 0 None - 0 Human 4.2 pIC50 = 4.2 Binding
Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8
ChEMBL 601 8 1 5 6.3 COc1ccc(N(C(=O)CN2C(=O)C(C)(Cc3n[nH]c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm960249k
CHEMBL88629 213324 0 None - 0 Human 4.2 pIC50 = 4.2 Binding
Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8
ChEMBL 601 8 1 5 6.3 COc1ccc(N(C(=O)CN2C(=O)C(C)(Cc3n[nH]c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm960249k
10769902 213324 0 None - 0 Human 4.2 pIC50 = 4.2 Binding
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 601 8 1 5 6.3 COc1ccc(N(C(=O)CN2C(=O)C(C)(Cc3n[nH]c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm970265x
CHEMBL88629 213324 0 None - 0 Human 4.2 pIC50 = 4.2 Binding
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 601 8 1 5 6.3 COc1ccc(N(C(=O)CN2C(=O)C(C)(Cc3n[nH]c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm970265x
CHEMBL434674 220439 0 None - 0 Human 4.2 pIC50 = 4.2 Binding
In vitro ability to inhibit [125I]Bolton-Hunter-CCK-8 binding to Cholecystokinin type B receptor in guinea pig cortexIn vitro ability to inhibit [125I]Bolton-Hunter-CCK-8 binding to Cholecystokinin type B receptor in guinea pig cortex
ChEMBL None None None CN[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1C)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00031a013
44303251 109011 0 None - 0 Mouse 6.2 pIC50 = 6.2 Binding
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 618 12 5 5 4.6 O=C(O)CCC(=O)N[C@@H](CNC(=O)C(Cc1c[nH]c2ccc(F)cc12)NC(=O)OC1C2CC3CC(C2)CC1C3)c1ccccc1 10.1016/S0960-894X(97)00356-9
CHEMBL303020 109011 0 None - 0 Mouse 6.2 pIC50 = 6.2 Binding
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 618 12 5 5 4.6 O=C(O)CCC(=O)N[C@@H](CNC(=O)C(Cc1c[nH]c2ccc(F)cc12)NC(=O)OC1C2CC3CC(C2)CC1C3)c1ccccc1 10.1016/S0960-894X(97)00356-9
443375 214385 45 None -389 5 Rat 6.2 pIC50 = 6.2 Binding
Binding affinity by competitive inhibition of the radioligand [3H]pCCK-8 at Cholecystokinin type B receptor from rat cerebral cortex membraneBinding affinity by competitive inhibition of the radioligand [3H]pCCK-8 at Cholecystokinin type B receptor from rat cerebral cortex membrane
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm991078x
CHEMBL9506 214385 45 None -389 5 Rat 6.2 pIC50 = 6.2 Binding
Binding affinity by competitive inhibition of the radioligand [3H]pCCK-8 at Cholecystokinin type B receptor from rat cerebral cortex membraneBinding affinity by competitive inhibition of the radioligand [3H]pCCK-8 at Cholecystokinin type B receptor from rat cerebral cortex membrane
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm991078x
443375 214385 45 None -389 5 Rat 6.2 pIC50 = 6.2 Binding
In vitro inhibition of [3H]propionyl-CCK-8 binding to rat cerebral cortex membranes at Cholecystokinin type B receptor.In vitro inhibition of [3H]propionyl-CCK-8 binding to rat cerebral cortex membranes at Cholecystokinin type B receptor.
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm000959x
CHEMBL9506 214385 45 None -389 5 Rat 6.2 pIC50 = 6.2 Binding
In vitro inhibition of [3H]propionyl-CCK-8 binding to rat cerebral cortex membranes at Cholecystokinin type B receptor.In vitro inhibition of [3H]propionyl-CCK-8 binding to rat cerebral cortex membranes at Cholecystokinin type B receptor.
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm000959x
44280621 110702 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 658 13 4 5 4.4 O=C(O)C[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NCCc1ccccc1 10.1021/jm950372w
CHEMBL30926 110702 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 658 13 4 5 4.4 O=C(O)C[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NCCc1ccccc1 10.1021/jm950372w
13822923 201595 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]gastrin from guinea pig gastric glandsDisplacement of [125I]gastrin from guinea pig gastric glands
ChEMBL 450 3 2 5 4.5 Cc1nnc2n1-c1ccccc1C(c1ccccc1F)=NC2NC(=O)c1cc2ccccc2[nH]1 10.1021/jm00396a028
CHEMBL53907 201595 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]gastrin from guinea pig gastric glandsDisplacement of [125I]gastrin from guinea pig gastric glands
ChEMBL 450 3 2 5 4.5 Cc1nnc2n1-c1ccccc1C(c1ccccc1F)=NC2NC(=O)c1cc2ccccc2[nH]1 10.1021/jm00396a028
44281205 121596 0 None - 1 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against gastrin receptor.Inhibitory activity against gastrin receptor.
ChEMBL 857 17 4 10 5.1 CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCCN3CCN(C(=O)CNCCCOc4cccc(CN5CCCCC5)c4)CC3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
CHEMBL33412 121596 0 None - 1 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against gastrin receptor.Inhibitory activity against gastrin receptor.
ChEMBL 857 17 4 10 5.1 CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCCN3CCN(C(=O)CNCCCOc4cccc(CN5CCCCC5)c4)CC3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
CHEMBL386811 219172 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Tested for inhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic aciniTested for inhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic acini
ChEMBL None None None CCCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)OCCc1ccccc1 10.1021/jm00072a024
104929 9000 9 None 51 3 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 10.1021/jm00121a004
3477 9000 9 None 51 3 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 10.1021/jm00121a004
879 9000 9 None 51 3 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 10.1021/jm00121a004
CHEMBL289498 9000 9 None 51 3 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 10.1021/jm00121a004
11756709 29648 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 528 9 3 6 3.7 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CCOC(=O)CCC(=O)O)C2=O)c1 10.1021/jm00078a018
CHEMBL132875 29648 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 528 9 3 6 3.7 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CCOC(=O)CCC(=O)O)C2=O)c1 10.1021/jm00078a018
5311201 214174 35 None -26 6 Mouse 8.1 pIC50 = 8.1 Binding
Inhibition of [125I]-labeled CCK-8 sulfate binding to CCK-B receptor in mouse brain membranesInhibition of [125I]-labeled CCK-8 sulfate binding to CCK-B receptor in mouse brain membranes
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00108a040
CHEMBL9387 214174 35 None -26 6 Mouse 8.1 pIC50 = 8.1 Binding
Inhibition of [125I]-labeled CCK-8 sulfate binding to CCK-B receptor in mouse brain membranesInhibition of [125I]-labeled CCK-8 sulfate binding to CCK-B receptor in mouse brain membranes
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00108a040
10648445 65687 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesInhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranes
ChEMBL 481 6 4 7 2.8 CN1C(=O)[C@H](NC(=O)Nc2cccc(CNc3nn[nH]n3)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm9506736
CHEMBL168903 65687 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesInhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranes
ChEMBL 481 6 4 7 2.8 CN1C(=O)[C@H](NC(=O)Nc2cccc(CNc3nn[nH]n3)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm9506736
10047669 85292 1 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 418 3 2 3 4.3 CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL2111924 85292 1 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 418 3 2 3 4.3 CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
46235271 80423 2 None -2 2 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I-CCK] from human CCK2R H7.39L mutant expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-CCK] from human CCK2R H7.39L mutant expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 649 7 1 6 6.7 Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 10.1021/acs.jmedchem.5b01110
CHEMBL2017835 80423 2 None -2 2 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I-CCK] from human CCK2R H7.39L mutant expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-CCK] from human CCK2R H7.39L mutant expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 649 7 1 6 6.7 Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 10.1021/acs.jmedchem.5b01110
10003805 114241 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Compound was tested for its binding affinity by measuring the displacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortexCompound was tested for its binding affinity by measuring the displacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortex
ChEMBL 448 4 2 5 2.9 CCCN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C(N2CCN(C)CC2)c2ccccc21 10.1016/0960-894X(95)00530-0
CHEMBL318360 114241 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Compound was tested for its binding affinity by measuring the displacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortexCompound was tested for its binding affinity by measuring the displacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortex
ChEMBL 448 4 2 5 2.9 CCCN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C(N2CCN(C)CC2)c2ccccc21 10.1016/0960-894X(95)00530-0
10369803 23354 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 532 7 3 3 5.7 CCC(C)(C)NC(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](c2ccccc2)c2ccccc21 10.1021/jm00048a015
CHEMBL123951 23354 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 532 7 3 3 5.7 CCC(C)(C)NC(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](c2ccccc2)c2ccccc21 10.1021/jm00048a015
15667017 214955 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 974 28 10 11 1.7 CCCC[C@H](NC(=O)/C=C/c1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
CHEMBL98332 214955 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 974 28 10 11 1.7 CCCC[C@H](NC(=O)/C=C/c1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
10392698 124084 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 546 5 3 3 5.9 Cc1ccc([C@H]2C[C@@H](NC(=O)Nc3cccc(Cl)c3)C(=O)N(CC(=O)NC(C)(C)C)c3cc(C)ccc32)cc1 10.1021/jm00048a015
CHEMBL339678 124084 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 546 5 3 3 5.9 Cc1ccc([C@H]2C[C@@H](NC(=O)Nc3cccc(Cl)c3)C(=O)N(CC(=O)NC(C)(C)C)c3cc(C)ccc32)cc1 10.1021/jm00048a015
10392523 214723 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 540 6 3 3 5.9 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)NC(C)(C)C)C2=O)c1 10.1016/S0960-894X(01)80832-5
CHEMBL96970 214723 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 540 6 3 3 5.9 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)NC(C)(C)C)C2=O)c1 10.1016/S0960-894X(01)80832-5
44301036 205483 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 695 8 4 6 5.4 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)NS(=O)(=O)c3ccccc3C)c1)C[C@@H]2c1ccccc1 10.1016/0960-894X(95)00327-P
CHEMBL58154 205483 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 695 8 4 6 5.4 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)NS(=O)(=O)c3ccccc3C)c1)C[C@@H]2c1ccccc1 10.1016/0960-894X(95)00327-P
15666987 214976 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vitro binding affinity towards Cholecystokinin type B receptor of guinea pig cortexIn vitro binding affinity towards Cholecystokinin type B receptor of guinea pig cortex
ChEMBL 976 29 10 11 1.6 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](CCCC)NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
CHEMBL98446 214976 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vitro binding affinity towards Cholecystokinin type B receptor of guinea pig cortexIn vitro binding affinity towards Cholecystokinin type B receptor of guinea pig cortex
ChEMBL 976 29 10 11 1.6 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](CCCC)NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
9934162 34504 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 464 5 3 4 4.3 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(Cc3c[nH]cn3)C2=O)c1 10.1021/jm00078a018
CHEMBL137043 34504 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 464 5 3 4 4.3 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(Cc3c[nH]cn3)C2=O)c1 10.1021/jm00078a018
101918113 122192 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cellsBinding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cells
ChEMBL 650 14 6 7 0.7 CS[C@H]1C[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)N(C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(C)=O)C1 10.1021/jm00001a019
CHEMBL3350334 122192 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cellsBinding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cells
ChEMBL 650 14 6 7 0.7 CS[C@H]1C[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)N(C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(C)=O)C1 10.1021/jm00001a019
CHEMBL37984 219046 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cellsBinding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cells
ChEMBL None None None CCCS[C@@H]1CCN(C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(C)=O)[C@@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00001a019
73349790 112953 0 None - 0 Mouse 7.2 pIC50 = 7.2 Binding
Evaluated for inhibition of CCK-B receptor by displacing [125I]bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of CCK-B receptor by displacing [125I]bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 725 14 5 6 5.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCNS(=O)(=O)c1ccccc1)c1ccccc1 10.1021/jm00092a007
CHEMBL313756 112953 0 None - 0 Mouse 7.2 pIC50 = 7.2 Binding
Evaluated for inhibition of CCK-B receptor by displacing [125I]bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of CCK-B receptor by displacing [125I]bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 725 14 5 6 5.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCNS(=O)(=O)c1ccccc1)c1ccccc1 10.1021/jm00092a007
14994683 212756 0 None - 0 Mouse 7.2 pIC50 = 7.2 Binding
Evaluated for inhibition of [125I]CCK-8S binding to cholecystokinin CCK-B receptor from mouse brain membranes at a concentration of 10 uM (in vitro)Evaluated for inhibition of [125I]CCK-8S binding to cholecystokinin CCK-B receptor from mouse brain membranes at a concentration of 10 uM (in vitro)
ChEMBL 437 6 1 4 6.0 CC(C)Oc1cccc(-n2c(CC(C)c3c[nH]c4ccccc34)nc3ccccc3c2=O)c1 10.1021/jm00092a003
CHEMBL84659 212756 0 None - 0 Mouse 7.2 pIC50 = 7.2 Binding
Evaluated for inhibition of [125I]CCK-8S binding to cholecystokinin CCK-B receptor from mouse brain membranes at a concentration of 10 uM (in vitro)Evaluated for inhibition of [125I]CCK-8S binding to cholecystokinin CCK-B receptor from mouse brain membranes at a concentration of 10 uM (in vitro)
ChEMBL 437 6 1 4 6.0 CC(C)Oc1cccc(-n2c(CC(C)c3c[nH]c4ccccc34)nc3ccccc3c2=O)c1 10.1021/jm00092a003
44381202 168610 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranesIn vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranes
ChEMBL 1139 31 10 12 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NC(Cc1ccccc1)Cc1ccccc1 10.1016/S0960-894X(00)80679-4
CHEMBL414523 168610 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranesIn vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranes
ChEMBL 1139 31 10 12 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NC(Cc1ccccc1)Cc1ccccc1 10.1016/S0960-894X(00)80679-4
44381463 103601 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic aciniIn vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic acini
ChEMBL 1124 30 10 12 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80679-4
CHEMBL265147 103601 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic aciniIn vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic acini
ChEMBL 1124 30 10 12 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80679-4
44396785 73952 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Inhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenatesInhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenates
ChEMBL 530 7 2 5 4.6 C[C@H]1C(=O)N(Cc2ccccc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC(C)(C)C)C12 10.1021/jm0498755
CHEMBL187732 73952 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Inhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenatesInhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenates
ChEMBL 530 7 2 5 4.6 C[C@H]1C(=O)N(Cc2ccccc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC(C)(C)C)C12 10.1021/jm0498755
19910130 126569 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 439 14 3 3 4.9 CCCCCN(CCCCC)C(=O)C(CCC(=O)O)NC(=O)Nc1ccc(Cl)cc1 10.1021/jm00164a020
CHEMBL348168 126569 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 439 14 3 3 4.9 CCCCCN(CCCCC)C(=O)C(CCC(=O)O)NC(=O)Nc1ccc(Cl)cc1 10.1021/jm00164a020
44349203 123832 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 455 7 3 4 3.6 O=C(O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)NN1CCC2(CCCCC2)C1 10.1021/jm00079a003
CHEMBL339134 123832 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 455 7 3 4 3.6 O=C(O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)NN1CCC2(CCCCC2)C1 10.1021/jm00079a003
44211352 20757 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
The compound was tested for its activity to inhibit the specific binding of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptorThe compound was tested for its activity to inhibit the specific binding of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor
ChEMBL 522 6 1 4 3.8 CN1CCN(C(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCC3)CC2)CC1 10.1016/S0960-894X(00)80681-2
CHEMBL1196916 20757 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
The compound was tested for its activity to inhibit the specific binding of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptorThe compound was tested for its activity to inhibit the specific binding of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor
ChEMBL 522 6 1 4 3.8 CN1CCN(C(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCC3)CC2)CC1 10.1016/S0960-894X(00)80681-2
CHEMBL558614 20757 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
The compound was tested for its activity to inhibit the specific binding of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptorThe compound was tested for its activity to inhibit the specific binding of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor
ChEMBL 522 6 1 4 3.8 CN1CCN(C(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCC3)CC2)CC1 10.1016/S0960-894X(00)80681-2
15689728 113378 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 880 20 9 8 4.6 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1c(Cl)cccc1Cl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
CHEMBL3142703 113378 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 880 20 9 8 4.6 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1c(Cl)cccc1Cl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
CHEMBL431899 220408 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Binding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cellsBinding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cells
ChEMBL None None None CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00001a019
44381577 103411 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Displacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptorDisplacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptor
ChEMBL 840 23 10 10 2.9 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(O)cc1)C(=O)N[C@H](CNN[C@@H](Cc1ccccc1)C(N)=O)CC(=O)O 10.1016/S0960-894X(00)80680-0
CHEMBL263525 103411 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Displacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptorDisplacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptor
ChEMBL 840 23 10 10 2.9 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(O)cc1)C(=O)N[C@H](CNN[C@@H](Cc1ccccc1)C(N)=O)CC(=O)O 10.1016/S0960-894X(00)80680-0
44311923 211280 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 421 4 2 3 4.0 O=C(Cc1ccc(Cl)cc1)NC1N=C(c2ccccc2F)c2ccccc2NC1=O 10.1021/jm00120a002
CHEMBL72570 211280 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 421 4 2 3 4.0 O=C(Cc1ccc(Cl)cc1)NC1N=C(c2ccccc2F)c2ccccc2NC1=O 10.1021/jm00120a002
14720386 55098 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 463 12 2 4 4.4 CCCN(CCC)C(=O)[C@H](CCC(=O)OCc1ccccc1)NC(=O)c1cc2ccccc2[nH]1 10.1021/jm00164a020
CHEMBL155406 55098 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 463 12 2 4 4.4 CCCN(CCC)C(=O)[C@H](CCC(=O)OCc1ccccc1)NC(=O)c1cc2ccccc2[nH]1 10.1021/jm00164a020
14991539 113571 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 859 22 8 8 3.8 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCc1ccc(Cl)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL3144533 113571 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 859 22 8 8 3.8 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCc1ccc(Cl)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
44349410 23549 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 394 7 3 3 3.5 O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NC1CCCCCCC1 10.1021/jm00079a003
CHEMBL124459 23549 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 394 7 3 3 3.5 O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NC1CCCCCCC1 10.1021/jm00079a003
CHEMBL172177 215630 0 None - 0 Mouse 4.2 pIC50 = 4.2 Binding
Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N1C[C@@H](Cc2ccccc2)NC(=O)[C@H]1CC(=O)O 10.1016/S0960-894X(01)80253-5
44280110 109667 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 587 10 3 4 4.9 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950372w
CHEMBL30592 109667 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 587 10 3 4 4.9 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950372w
10350069 16745 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
In vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cellsIn vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL 742 17 7 6 5.8 Cc1ccccc1NC(=O)NCCCC[C@@H](CNC(=O)CCC(=O)O)NC(=O)[C@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1021/jm00017a022
CHEMBL114774 16745 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
In vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cellsIn vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL 742 17 7 6 5.8 Cc1ccccc1NC(=O)NCCCC[C@@H](CNC(=O)CCC(=O)O)NC(=O)[C@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1021/jm00017a022
44283246 106738 0 None - 0 Mouse 6.2 pIC50 = 6.2 Binding
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 527 8 2 4 6.8 O=C(NC(Cc1c[nH]c2ccccc12)C1CN=C(CCc2ccccc2)S1)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
CHEMBL286442 106738 0 None - 0 Mouse 6.2 pIC50 = 6.2 Binding
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 527 8 2 4 6.8 O=C(NC(Cc1c[nH]c2ccccc12)C1CN=C(CCc2ccccc2)S1)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
44329323 114120 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 574 7 3 3 6.9 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)Nc3ccccc3C)C2=O)c1 10.1016/S0960-894X(01)80832-5
CHEMBL317615 114120 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 574 7 3 3 6.9 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)Nc3ccccc3C)C2=O)c1 10.1016/S0960-894X(01)80832-5
44381815 65781 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptorDisplacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptor
ChEMBL 838 21 7 9 4.0 CN(C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCNC(=O)/C=C\c1ccc(O)cc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80680-0
CHEMBL169126 65781 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptorDisplacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptor
ChEMBL 838 21 7 9 4.0 CN(C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCNC(=O)/C=C\c1ccc(O)cc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80680-0
9962694 175013 4 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 853 21 8 9 3.3 CN(C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCNC(=O)/C=C/c1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL433640 175013 4 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 853 21 8 9 3.3 CN(C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCNC(=O)/C=C/c1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
44280381 109721 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 511 9 3 4 3.6 O=C(O)CCNC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL30634 109721 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 511 9 3 4 3.6 O=C(O)CCNC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
11734332 85367 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
Inhibition of [3H]pCCK-8 specific binding cholecystokinin type B receptor in rat cerebral cortex membranesInhibition of [3H]pCCK-8 specific binding cholecystokinin type B receptor in rat cerebral cortex membranes
ChEMBL 551 6 3 5 4.2 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)N(C3CCCCC3)C(=O)C[C@H]12 10.1021/jm010813d
CHEMBL2112233 85367 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
Inhibition of [3H]pCCK-8 specific binding cholecystokinin type B receptor in rat cerebral cortex membranesInhibition of [3H]pCCK-8 specific binding cholecystokinin type B receptor in rat cerebral cortex membranes
ChEMBL 551 6 3 5 4.2 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)N(C3CCCCC3)C(=O)C[C@H]12 10.1021/jm010813d
10047370 85592 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 413 4 3 4 3.1 CN1C(=O)[C@H](NC(=O)Nc2cccc(CN)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL2112754 85592 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 413 4 3 4 3.1 CN1C(=O)[C@H](NC(=O)Nc2cccc(CN)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
44381513 175473 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranesIn vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranes
ChEMBL 1139 31 10 12 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NC(Cc1ccccc1)Cc1ccccc1 10.1016/S0960-894X(00)80679-4
CHEMBL436690 175473 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranesIn vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranes
ChEMBL 1139 31 10 12 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NC(Cc1ccccc1)Cc1ccccc1 10.1016/S0960-894X(00)80679-4
14843031 148071 0 None - 0 Mouse 7.1 pIC50 = 7.1 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 393 5 1 3 5.2 CCc1cccc(-n2c(CCc3c[nH]c4ccccc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
CHEMBL38330 148071 0 None - 0 Mouse 7.1 pIC50 = 7.1 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 393 5 1 3 5.2 CCc1cccc(-n2c(CCc3c[nH]c4ccccc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
10389643 125799 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 462 5 3 4 3.8 O=C(O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL342614 125799 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 462 5 3 4 3.8 O=C(O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
3476 8182 9 None -117 3 Human 6.1 pIC50 = 6.1 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 408 3 2 3 3.7 O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 10.1021/jm00120a002
59751 8182 9 None -117 3 Human 6.1 pIC50 = 6.1 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 408 3 2 3 3.7 O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 10.1021/jm00120a002
878 8182 9 None -117 3 Human 6.1 pIC50 = 6.1 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 408 3 2 3 3.7 O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 10.1021/jm00120a002
CHEMBL39263 8182 9 None -117 3 Human 6.1 pIC50 = 6.1 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 408 3 2 3 3.7 O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 10.1021/jm00120a002
19754254 127128 0 None - 0 Human 4.1 pIC50 = 4.1 Binding
Tested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brainTested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL 321 2 2 2 4.6 O=C(Nc1cc2c3ccccc3nc-2c[nH]1)c1ccc(Cl)cc1 10.1016/S0960-894X(00)80682-4
CHEMBL353088 127128 0 None - 0 Human 4.1 pIC50 = 4.1 Binding
Tested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brainTested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL 321 2 2 2 4.6 O=C(Nc1cc2c3ccccc3nc-2c[nH]1)c1ccc(Cl)cc1 10.1016/S0960-894X(00)80682-4
44396745 131816 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of 125I]-BH-(Thr,Nle)-CCK-9 binding to human CCK2 receptor expressed in COS-7 cellsInhibition of 125I]-BH-(Thr,Nle)-CCK-9 binding to human CCK2 receptor expressed in COS-7 cells
ChEMBL 623 8 2 6 5.5 CN(C)c1ccc(N2C(=O)CC3[C@H](N[C@@H](Cc4c[nH]c5ccccc45)C(=O)OC4C5CC6CC(C5)CC4C6)CCCN3C2=O)cc1 10.1021/jm0498755
CHEMBL364334 131816 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of 125I]-BH-(Thr,Nle)-CCK-9 binding to human CCK2 receptor expressed in COS-7 cellsInhibition of 125I]-BH-(Thr,Nle)-CCK-9 binding to human CCK2 receptor expressed in COS-7 cells
ChEMBL 623 8 2 6 5.5 CN(C)c1ccc(N2C(=O)CC3[C@H](N[C@@H](Cc4c[nH]c5ccccc45)C(=O)OC4C5CC6CC(C5)CC4C6)CCCN3C2=O)cc1 10.1021/jm0498755
10817407 113908 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 601 7 1 6 5.6 CC(C)N(C(=O)CN1C(=O)C(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc21)c1ccc2c(c1)OCO2 10.1021/jm970265x
CHEMBL316106 113908 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 601 7 1 6 5.6 CC(C)N(C(=O)CN1C(=O)C(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc21)c1ccc2c(c1)OCO2 10.1021/jm970265x
44280113 175009 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 684 12 4 5 5.5 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1ccc2c(c1)CCC2 10.1021/jm950372w
CHEMBL433623 175009 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 684 12 4 5 5.5 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1ccc2c(c1)CCC2 10.1021/jm950372w
10575687 214019 0 None - 0 Mouse 7.1 pIC50 = 7.1 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 453 4 3 5 5.2 Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(Cl)c2Cl)c1 10.1021/jm970373j
CHEMBL9287 214019 0 None - 0 Mouse 7.1 pIC50 = 7.1 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 453 4 3 5 5.2 Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(Cl)c2Cl)c1 10.1021/jm970373j
10074366 127376 0 None - 0 Mouse 7.1 pIC50 = 7.1 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 9 4 4 4.5 C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
CHEMBL3349028 127376 0 None - 0 Mouse 7.1 pIC50 = 7.1 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 9 4 4 4.5 C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
CHEMBL3545866 127376 0 None - 0 Mouse 7.1 pIC50 = 7.1 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 9 4 4 4.5 C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
44381479 66298 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptorDisplacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptor
ChEMBL 824 21 8 9 3.7 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)[C@@H](CCCCNC(=O)/C=C\c1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80680-0
CHEMBL171593 66298 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptorDisplacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptor
ChEMBL 824 21 8 9 3.7 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)[C@@H](CCCCNC(=O)/C=C\c1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80680-0
10452527 147497 0 None - 0 Mouse 6.1 pIC50 = 6.1 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 383 4 1 3 4.8 O=c1c2ccccc2nc(CCc2c[nH]c3ccccc23)n1-c1cccc(F)c1 10.1021/jm00108a040
CHEMBL38176 147497 0 None - 0 Mouse 6.1 pIC50 = 6.1 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 383 4 1 3 4.8 O=c1c2ccccc2nc(CCc2c[nH]c3ccccc23)n1-c1cccc(F)c1 10.1021/jm00108a040
90663974 113574 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 839 21 9 9 3.0 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL3144536 113574 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 839 21 9 9 3.0 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
14991584 168521 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 877 20 8 9 4.1 CN(C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCNC(=O)c1ccc2cc(O)ccc2c1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL413768 168521 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 877 20 8 9 4.1 CN(C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCNC(=O)c1ccc2cc(O)ccc2c1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
14208280 74462 0 None - 0 Human 4.1 pIC50 = 4.1 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 335 3 1 3 2.6 CC(C)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2N(C)C1=O 10.1021/jm00120a002
CHEMBL1907665 74462 0 None - 0 Human 4.1 pIC50 = 4.1 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 335 3 1 3 2.6 CC(C)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2N(C)C1=O 10.1021/jm00120a002
44458096 91824 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Displacement of [125I]CCK-OP radioligand from Cholecystokinin type B receptor of guinea pig cortical membranesDisplacement of [125I]CCK-OP radioligand from Cholecystokinin type B receptor of guinea pig cortical membranes
ChEMBL 388 5 2 3 2.7 O=C(N[C@@H]1C(=O)N(Cc2ccccc2)C[C@@H]1C(=O)O)c1ccc2ccccc2c1 10.1016/S0960-894X(00)80224-3
CHEMBL22417 91824 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Displacement of [125I]CCK-OP radioligand from Cholecystokinin type B receptor of guinea pig cortical membranesDisplacement of [125I]CCK-OP radioligand from Cholecystokinin type B receptor of guinea pig cortical membranes
ChEMBL 388 5 2 3 2.7 O=C(N[C@@H]1C(=O)N(Cc2ccccc2)C[C@@H]1C(=O)O)c1ccc2ccccc2c1 10.1016/S0960-894X(00)80224-3
CHEMBL172135 215629 0 None - 0 Mouse 5.1 pIC50 = 5.1 Binding
Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N1C[C@H](Cc2ccccc2)NC(=O)[C@H]1CC(=O)O 10.1016/S0960-894X(01)80253-5
10260206 174253 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL 918 21 8 8 4.9 Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
CHEMBL429932 174253 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL 918 21 8 8 4.9 Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
15104595 16864 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 498 13 2 3 6.3 CCCCCN(CCCCC)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1cnc2ccccc2c1 10.1021/jm00116a002
CHEMBL115456 16864 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 498 13 2 3 6.3 CCCCCN(CCCCC)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1cnc2ccccc2c1 10.1021/jm00116a002
15167799 125965 0 None - 0 Human 4.1 pIC50 = 4.1 Binding
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 379 4 2 4 3.9 O=C(NCC1CNc2ccccc2C(c2ccccc2F)=N1)c1ccsc1 10.1021/jm00163a069
CHEMBL343158 125965 0 None - 0 Human 4.1 pIC50 = 4.1 Binding
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 379 4 2 4 3.9 O=C(NCC1CNc2ccccc2C(c2ccccc2F)=N1)c1ccsc1 10.1021/jm00163a069
10819755 172221 0 None - 2 Human 5.1 pIC50 = 5.1 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 976 28 9 11 1.6 CCCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL423907 172221 0 None - 2 Human 5.1 pIC50 = 5.1 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 976 28 9 11 1.6 CCCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
155551968 180796 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1793 69 16 20 4.5 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4542927 180796 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1793 69 16 20 4.5 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
73346731 88321 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat TcellsInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat Tcells
ChEMBL 1017 29 9 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCCc1ccccc1)CC(=O)O 10.1021/jm00072a024
CHEMBL216079 88321 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat TcellsInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat Tcells
ChEMBL 1017 29 9 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCCc1ccccc1)CC(=O)O 10.1021/jm00072a024
CHEMBL432671 174874 0 None - 1 Mouse 7.1 pIC50 = 7.1 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 784 15 7 12 3.1 CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCNC(=O)CC(=O)NCCSCc3csc(C=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
44280714 106809 0 None - 1 Human 7.1 pIC50 = 7.1 Binding
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 726 14 6 9 3.2 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCC(=O)NCCSCc3csc(N=C(N)N)n3)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL286908 106809 0 None - 1 Human 7.1 pIC50 = 7.1 Binding
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 726 14 6 9 3.2 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCC(=O)NCCSCc3csc(N=C(N)N)n3)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL2370879 216720 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Compound was tested for its inhibitory activity in cortical cholecystokinin type B receptor in guinea pigCompound was tested for its inhibitory activity in cortical cholecystokinin type B receptor in guinea pig
ChEMBL None None None CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00105a068
CHEMBL3142924 217917 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL None None None COc1ccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 10.1021/jm960509y
14208293 74524 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 465 3 1 3 4.2 CN1C(=O)[C@@H](NC(=O)c2cccc(Br)c2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL1907851 74524 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 465 3 1 3 4.2 CN1C(=O)[C@@H](NC(=O)c2cccc(Br)c2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
14444018 113453 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
In vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 649 16 6 6 3.8 CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(=O)O)CC(=O)NCCc1ccccc1 10.1021/jm00123a003
CHEMBL3143387 113453 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
In vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 649 16 6 6 3.8 CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(=O)O)CC(=O)NCCc1ccccc1 10.1021/jm00123a003
90663982 113589 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 855 21 10 10 2.7 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(O)c(O)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL3144551 113589 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 855 21 10 10 2.7 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(O)c(O)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
14208251 84602 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 403 3 1 3 3.9 CN1C(=O)[C@H](NC(=O)c2ccccc2Cl)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
CHEMBL2092870 84602 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 403 3 1 3 3.9 CN1C(=O)[C@H](NC(=O)c2ccccc2Cl)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
44377488 64281 0 None - 0 Human 4.1 pIC50 = 4.1 Binding
In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.
ChEMBL 693 21 6 8 3.5 CCCCOC(=O)CCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCCC)NC(=O)[C@H](CC(=O)O)NC(=O)OCc1ccccc1 10.1021/jm00388a002
CHEMBL166089 64281 0 None - 0 Human 4.1 pIC50 = 4.1 Binding
In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.
ChEMBL 693 21 6 8 3.5 CCCCOC(=O)CCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCCC)NC(=O)[C@H](CC(=O)O)NC(=O)OCc1ccccc1 10.1021/jm00388a002
10279334 131835 0 None - 0 Mouse 6.1 pIC50 = 6.1 Binding
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 513 8 2 3 5.7 CN(CCc1ccccc1)C(=O)C(C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
CHEMBL36443 131835 0 None - 0 Mouse 6.1 pIC50 = 6.1 Binding
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 513 8 2 3 5.7 CN(CCc1ccccc1)C(=O)C(C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
155535107 178793 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1904 73 19 22 4.7 CCCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4471525 178793 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1904 73 19 22 4.7 CCCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
14888719 84011 0 None - 0 Bovine 7.1 pIC50 = 7.1 Binding
Inhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranesInhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranes
ChEMBL 1041 29 11 14 -0.1 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@@H](Cc1ccc(-c2nn[nH]n2)cc1)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00107a037
CHEMBL2079547 84011 0 None - 0 Bovine 7.1 pIC50 = 7.1 Binding
Inhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranesInhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranes
ChEMBL 1041 29 11 14 -0.1 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@@H](Cc1ccc(-c2nn[nH]n2)cc1)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00107a037
44280373 106164 0 None - 1 Mouse 6.1 pIC50 = 6.1 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 773 16 4 8 5.4 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL282646 106164 0 None - 1 Mouse 6.1 pIC50 = 6.1 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 773 16 4 8 5.4 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
10260012 116426 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL 858 22 8 7 3.7 Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)Cc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
CHEMBL322391 116426 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL 858 22 8 7 3.7 Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)Cc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
10320031 84600 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 421 3 1 3 4.0 CN1C(=O)[C@H](NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00121a004
CHEMBL2092868 84600 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 421 3 1 3 4.0 CN1C(=O)[C@H](NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00121a004
44341613 16385 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 516 13 2 3 6.4 CCCCCN(CCCCC)C(=O)[C@H](Cc1c[nH]c2ccc(F)cc12)NC(=O)c1cnc2ccccc2c1 10.1021/jm00116a002
CHEMBL112622 16385 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 516 13 2 3 6.4 CCCCCN(CCCCC)C(=O)[C@H](Cc1c[nH]c2ccc(F)cc12)NC(=O)c1cnc2ccccc2c1 10.1021/jm00116a002
10553481 170062 0 None - 0 Mouse 5.1 pIC50 = 5.1 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 501 8 3 8 4.5 CCOC(=O)c1ccccc1NC(=O)NNc1nc2ccccc2c(=O)n1-c1cccc(OC(C)C)c1 10.1021/jm970373j
CHEMBL418700 170062 0 None - 0 Mouse 5.1 pIC50 = 5.1 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 501 8 3 8 4.5 CCOC(=O)c1ccccc1NC(=O)NNc1nc2ccccc2c(=O)n1-c1cccc(OC(C)C)c1 10.1021/jm970373j
73355866 213011 0 None - 0 Mouse 7.1 pIC50 = 7.1 Binding
Evaluated for inhibition of CCK-B receptor by displacing [125I]bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of CCK-B receptor by displacing [125I]bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 717 13 5 6 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCNS(=O)(=O)C(F)(F)F)c1ccccc1 10.1021/jm00092a007
CHEMBL86702 213011 0 None - 0 Mouse 7.1 pIC50 = 7.1 Binding
Evaluated for inhibition of CCK-B receptor by displacing [125I]bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of CCK-B receptor by displacing [125I]bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 717 13 5 6 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCNS(=O)(=O)C(F)(F)F)c1ccccc1 10.1021/jm00092a007
15673149 92767 0 None - 0 Mouse 7.1 pIC50 = 7.1 Binding
The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the mouse cerebral cortex (CCK-B);value ranges from 62 to 98The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the mouse cerebral cortex (CCK-B);value ranges from 62 to 98
ChEMBL 717 13 5 6 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCNS(=O)(=O)C(F)(F)F)c1ccccc1 10.1016/S0960-894X(00)80652-6
CHEMBL2304151 92767 0 None - 0 Mouse 7.1 pIC50 = 7.1 Binding
The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the mouse cerebral cortex (CCK-B);value ranges from 62 to 98The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the mouse cerebral cortex (CCK-B);value ranges from 62 to 98
ChEMBL 717 13 5 6 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCNS(=O)(=O)C(F)(F)F)c1ccccc1 10.1016/S0960-894X(00)80652-6
CHEMBL3142697 217912 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL None None None CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccc(Cl)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
CHEMBL350222 218502 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
In vitro ability to inhibit [125I]Bolton-Hunter-CCK-8 binding to Cholecystokinin type B receptor in guinea pig cortexIn vitro ability to inhibit [125I]Bolton-Hunter-CCK-8 binding to Cholecystokinin type B receptor in guinea pig cortex
ChEMBL None None None Cc1ccccc1NC(=O)N(C)CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00031a013
11801911 118292 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 613 8 1 5 6.4 COc1ccc(N(C(=O)CN2C(=O)C(Cc3n[nH]c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C2CCCC2)cc1 10.1021/jm970265x
CHEMBL327849 118292 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 613 8 1 5 6.4 COc1ccc(N(C(=O)CN2C(=O)C(Cc3n[nH]c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C2CCCC2)cc1 10.1021/jm970265x
155532759 178534 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1431 50 12 15 5.6 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4467402 178534 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1431 50 12 15 5.6 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
16100410 148576 0 None -7079 4 Human 5.1 pIC50 = 5.1 Binding
Displacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1031 27 13 12 0.2 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@H](Cc1cc2ccccc2[nH]1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061268p
CHEMBL386212 148576 0 None -7079 4 Human 5.1 pIC50 = 5.1 Binding
Displacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1031 27 13 12 0.2 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@H](Cc1cc2ccccc2[nH]1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061268p
44280315 108396 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 672 13 3 5 5.1 CN(Cc1ccccc1)C(=O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O 10.1021/jm950372w
CHEMBL29891 108396 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 672 13 3 5 5.1 CN(Cc1ccccc1)C(=O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O 10.1021/jm950372w
44359338 175445 0 None - 0 Mouse 7.1 pIC50 = 7.1 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 489 6 3 3 5.3 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1CC2CCC1C2 10.1021/jm970065l
CHEMBL436411 175445 0 None - 0 Mouse 7.1 pIC50 = 7.1 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 489 6 3 3 5.3 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1CC2CCC1C2 10.1021/jm970065l
44349102 175108 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 434 7 3 3 4.3 O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NC1CCC2(CCCCC2)CC1 10.1021/jm00079a003
CHEMBL434250 175108 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 434 7 3 3 4.3 O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NC1CCC2(CCCCC2)CC1 10.1021/jm00079a003
44377852 172070 0 None - 0 Human 4.1 pIC50 = 4.1 Binding
In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.
ChEMBL 692 21 7 7 3.1 CCCCOC(=O)CCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCCC)NC(=O)[C@H](CC(=O)O)NC(=O)NCc1ccccc1 10.1021/jm00388a002
CHEMBL423260 172070 0 None - 0 Human 4.1 pIC50 = 4.1 Binding
In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.
ChEMBL 692 21 7 7 3.1 CCCCOC(=O)CCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCCC)NC(=O)[C@H](CC(=O)O)NC(=O)NCc1ccccc1 10.1021/jm00388a002
10252366 32656 14 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 434 3 2 3 4.8 CN1C(=O)C(NC(=O)Nc2cccc3ccccc23)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL135364 32656 14 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 434 3 2 3 4.8 CN1C(=O)C(NC(=O)Nc2cccc3ccccc23)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
44329325 168580 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 594 7 3 3 7.2 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)Nc3cccc(Cl)c3)C2=O)c1 10.1016/S0960-894X(01)80832-5
CHEMBL414223 168580 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 594 7 3 3 7.2 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)Nc3cccc(Cl)c3)C2=O)c1 10.1016/S0960-894X(01)80832-5
44280266 105553 0 None - 1 Human 6.1 pIC50 = 6.1 Binding
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 729 14 4 7 5.0 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL278217 105553 0 None - 1 Human 6.1 pIC50 = 6.1 Binding
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 729 14 4 7 5.0 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 10.1016/S0960-894X(96)00248-X
10555363 103262 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligandBinding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligand
ChEMBL 588 9 1 4 6.6 CCC1(CC(=O)Nc2ccccc2)C(=O)N(CC(=O)N(c2ccccc2)C(C)C)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm960205b
CHEMBL262444 103262 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligandBinding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligand
ChEMBL 588 9 1 4 6.6 CCC1(CC(=O)Nc2ccccc2)C(=O)N(CC(=O)N(c2ccccc2)C(C)C)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm960205b
44280508 106602 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 601 10 3 4 5.3 CC(Cc1ccccc1)(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O 10.1021/jm950372w
CHEMBL285559 106602 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 601 10 3 4 5.3 CC(Cc1ccccc1)(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O 10.1021/jm950372w
10392653 125819 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 544 5 2 5 3.4 CN1CCN(C(=O)CN2C(=O)C(NC(=O)Nc3ccc(Cl)cc3)N=C(c3ccccc3)c3ccccc32)CC1 10.1016/S0960-894X(00)80683-6
CHEMBL342640 125819 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 544 5 2 5 3.4 CN1CCN(C(=O)CN2C(=O)C(NC(=O)Nc3ccc(Cl)cc3)N=C(c3ccccc3)c3ccccc32)CC1 10.1016/S0960-894X(00)80683-6
10720107 213462 0 None - 0 Mouse 8.1 pIC50 = 8.1 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 497 6 3 6 5.3 CC(C)Oc1cccc(-n2c(NNC(=O)Nc3cccc(C(F)(F)F)c3)nc3ccccc3c2=O)c1 10.1021/jm970373j
CHEMBL8954 213462 0 None - 0 Mouse 8.1 pIC50 = 8.1 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 497 6 3 6 5.3 CC(C)Oc1cccc(-n2c(NNC(=O)Nc3cccc(C(F)(F)F)c3)nc3ccccc3c2=O)c1 10.1021/jm970373j
10456021 214287 1 None - 0 Mouse 8.1 pIC50 = 8.1 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 442 4 2 5 3.4 COC(=O)c1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm970373j
CHEMBL9449 214287 1 None - 0 Mouse 8.1 pIC50 = 8.1 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 442 4 2 5 3.4 COC(=O)c1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm970373j
9868877 214445 0 None - 0 Mouse 8.1 pIC50 = 8.1 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 460 8 2 4 3.8 COc1cccc(N(CC(=O)N(C)c2ccccc2)C(=O)CNC(=O)Nc2cccc(C)c2)c1 10.1021/jm970373j
CHEMBL9534 214445 0 None - 0 Mouse 8.1 pIC50 = 8.1 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 460 8 2 4 3.8 COc1cccc(N(CC(=O)N(C)c2ccccc2)C(=O)CNC(=O)Nc2cccc(C)c2)c1 10.1021/jm970373j
135837528 127014 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligandBinding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligand
ChEMBL 472 5 3 5 3.7 Cc1cccc(NC(=O)NC2N=C(c3ncc[nH]3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1016/0960-894X(95)00557-A
CHEMBL352217 127014 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligandBinding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligand
ChEMBL 472 5 3 5 3.7 Cc1cccc(NC(=O)NC2N=C(c3ncc[nH]3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1016/0960-894X(95)00557-A
155556375 181283 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter methodDisplacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter method
ChEMBL 1409 38 15 21 -2.1 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)n1cc([C@@H](CCC(=O)O)NC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)nn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.9b01936
CHEMBL4554965 181283 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter methodDisplacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter method
ChEMBL 1409 38 15 21 -2.1 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)n1cc([C@@H](CCC(=O)O)NC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)nn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.9b01936
10456021 214287 1 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 442 4 2 5 3.4 COC(=O)c1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
CHEMBL9449 214287 1 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 442 4 2 5 3.4 COC(=O)c1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
5311201 214174 35 None -27 6 Human 8.1 pIC50 = 8.1 Binding
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/0960-894X(95)00327-P
CHEMBL9387 214174 35 None -27 6 Human 8.1 pIC50 = 8.1 Binding
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/0960-894X(95)00327-P
5311201 214174 35 None -27 6 Human 8.1 pIC50 = 8.1 Binding
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00048a015
CHEMBL9387 214174 35 None -27 6 Human 8.1 pIC50 = 8.1 Binding
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00048a015
5311201 214174 35 None -27 6 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(01)80832-5
CHEMBL9387 214174 35 None -27 6 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(01)80832-5
4627 7609 50 None -1 5 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL None None None None 10.1021/jm00173a006
864 7609 50 None -1 5 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL None None None None 10.1021/jm00173a006
9833444 7609 50 None -1 5 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL None None None None 10.1021/jm00173a006
CHEMBL1121 7609 50 None -1 5 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL None None None None 10.1021/jm00173a006
DB09142 7609 50 None -1 5 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL None None None None 10.1021/jm00173a006
44303527 103264 0 None - 0 Mouse 8.1 pIC50 = 8.1 Binding
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 632 12 5 5 5.0 CC(Cc1c[nH]c2ccc(F)cc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1 10.1016/S0960-894X(97)00356-9
CHEMBL262456 103264 0 None - 0 Mouse 8.1 pIC50 = 8.1 Binding
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 632 12 5 5 5.0 CC(Cc1c[nH]c2ccc(F)cc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1 10.1016/S0960-894X(97)00356-9
5311201 214174 35 None -27 6 Human 8.1 pIC50 = 8.1 Binding
Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00032a002
CHEMBL9387 214174 35 None -27 6 Human 8.1 pIC50 = 8.1 Binding
Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00032a002
5311201 214174 35 None -26 6 Mouse 8.1 pIC50 = 8.1 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm970373j
CHEMBL9387 214174 35 None -26 6 Mouse 8.1 pIC50 = 8.1 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm970373j
CHEMBL2386886 217177 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of Eu-DTPA-CCK8 from CCK2 receptor in HEK293 cells after 2 hrs by TRF assayDisplacement of Eu-DTPA-CCK8 from CCK2 receptor in HEK293 cells after 2 hrs by TRF assay
ChEMBL None None None C#CCCC(=O)NCCCC[C@H](NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1cn(CC(=O)NCCC(=O)NCCC(=O)NCCCC(CCCNC(=O)CCNC(=O)CCNC(=O)Cn2cc(NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCC)N(C)C(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCCNC(=O)CCC#C)NC(C)=O)nn2)(NC(=O)CNC(=O)CCNC(=O)CCNC(=O)Cn2cc(NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCC)N(C)C(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCCNC(=O)CCC#C)NC(C)=O)nn2)C(=O)NCCC(N)=O)nn1 10.1016/j.bmcl.2013.02.022
5311201 214174 35 None -27 6 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortexDisplacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortex
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/0960-894X(95)00530-0
CHEMBL9387 214174 35 None -27 6 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortexDisplacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortex
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/0960-894X(95)00530-0
5311201 214174 35 None -27 6 Human 8.1 pIC50 = 8.1 Binding
In vitro test for inhibition of [125I]CCK binding to Cholecystokinin type B receptor from guinea pig cortical membranes was determinedIn vitro test for inhibition of [125I]CCK binding to Cholecystokinin type B receptor from guinea pig cortical membranes was determined
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(01)80987-2
CHEMBL9387 214174 35 None -27 6 Human 8.1 pIC50 = 8.1 Binding
In vitro test for inhibition of [125I]CCK binding to Cholecystokinin type B receptor from guinea pig cortical membranes was determinedIn vitro test for inhibition of [125I]CCK binding to Cholecystokinin type B receptor from guinea pig cortical membranes was determined
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(01)80987-2
5311201 214174 35 None -27 6 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesInhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranes
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm9506736
CHEMBL9387 214174 35 None -27 6 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesInhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranes
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm9506736
5311201 214174 35 None -26 6 Mouse 8.1 pIC50 = 8.1 Binding
Inhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(97)00108-X
CHEMBL9387 214174 35 None -26 6 Mouse 8.1 pIC50 = 8.1 Binding
Inhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(97)00108-X
5311201 214174 35 None -27 6 Human 8.1 pIC50 = 8.1 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
CHEMBL9387 214174 35 None -27 6 Human 8.1 pIC50 = 8.1 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
5311201 214174 35 None -27 6 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against Cholecystokinin type B receptor in guinea pig cerebral cortex using [125 I ]- CCK-8 as radioligand.Inhibitory activity against Cholecystokinin type B receptor in guinea pig cerebral cortex using [125 I ]- CCK-8 as radioligand.
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/0960-894X(95)00234-K
CHEMBL9387 214174 35 None -27 6 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against Cholecystokinin type B receptor in guinea pig cerebral cortex using [125 I ]- CCK-8 as radioligand.Inhibitory activity against Cholecystokinin type B receptor in guinea pig cerebral cortex using [125 I ]- CCK-8 as radioligand.
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/0960-894X(95)00234-K
44376130 63110 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
The compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligandThe compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligand
ChEMBL 398 3 2 3 4.0 Cc1ccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc1 10.1021/jm00032a003
CHEMBL163049 63110 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
The compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligandThe compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligand
ChEMBL 398 3 2 3 4.0 Cc1ccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc1 10.1021/jm00032a003
5311201 214174 35 None -27 6 Human 8.1 pIC50 = 8.1 Binding
The concentration required for half maximal inhibition of the binding to Cholecystokinin type B receptor (CCK-B) from guinea pig cortical membraneThe concentration required for half maximal inhibition of the binding to Cholecystokinin type B receptor (CCK-B) from guinea pig cortical membrane
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm9608523
CHEMBL9387 214174 35 None -27 6 Human 8.1 pIC50 = 8.1 Binding
The concentration required for half maximal inhibition of the binding to Cholecystokinin type B receptor (CCK-B) from guinea pig cortical membraneThe concentration required for half maximal inhibition of the binding to Cholecystokinin type B receptor (CCK-B) from guinea pig cortical membrane
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm9608523
145991539 173692 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
Displacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting methodDisplacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting method
ChEMBL 509 5 4 6 4.2 O=C(O)c1cccc(NC(=S)NNc2nc3ccccc3c(=O)n2-c2cccc(Br)c2)c1 10.1039/C7MD00171A
CHEMBL4286509 173692 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
Displacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting methodDisplacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting method
ChEMBL 509 5 4 6 4.2 O=C(O)c1cccc(NC(=S)NNc2nc3ccccc3c(=O)n2-c2cccc(Br)c2)c1 10.1039/C7MD00171A
44330874 215141 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 974 28 10 11 2.1 CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N/C(=C\c1ccccc1)C(N)=O 10.1021/jm00094a001
CHEMBL99499 215141 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 974 28 10 11 2.1 CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N/C(=C\c1ccccc1)C(N)=O 10.1021/jm00094a001
14802508 85566 0 None - 0 Mouse 8.1 pIC50 = 8.1 Binding
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 615 12 4 6 5.3 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCC(OC(=O)CCC(=O)O)c1ccccc1 10.1021/jm00105a062
CHEMBL2112695 85566 0 None - 0 Mouse 8.1 pIC50 = 8.1 Binding
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 615 12 4 6 5.3 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCC(OC(=O)CCC(=O)O)c1ccccc1 10.1021/jm00105a062
10325557 53282 0 None - 0 Mouse 8.1 pIC50 = 8.1 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 563 9 4 4 5.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC12C[C@@H]3C[C@@H](C[C@@H](C3)C1)C2Cl)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
CHEMBL153760 53282 0 None - 0 Mouse 8.1 pIC50 = 8.1 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 563 9 4 4 5.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC12C[C@@H]3C[C@@H](C[C@@H](C3)C1)C2Cl)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
73355867 213039 0 None - 0 Mouse 7.1 pIC50 = 7.1 Binding
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 680 12 5 6 6.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CSc1ccccc1O)c1ccccc1 10.1021/jm00092a007
CHEMBL86879 213039 0 None - 0 Mouse 7.1 pIC50 = 7.1 Binding
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 680 12 5 6 6.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CSc1ccccc1O)c1ccccc1 10.1021/jm00092a007
10102593 148283 2 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranesIn vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranes
ChEMBL 1048 29 10 12 3.3 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 10.1016/S0960-894X(00)80679-4
CHEMBL384505 148283 2 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranesIn vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranes
ChEMBL 1048 29 10 12 3.3 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 10.1016/S0960-894X(00)80679-4
44329304 114895 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 526 7 3 3 5.5 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)NC(C)C)C2=O)c1 10.1016/S0960-894X(01)80832-5
CHEMBL319569 114895 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 526 7 3 3 5.5 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)NC(C)C)C2=O)c1 10.1016/S0960-894X(01)80832-5
44279861 109961 0 None - 1 Human 7.1 pIC50 = 7.1 Binding
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 726 14 6 9 3.1 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCC(=O)NCCSCc3csc(N=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
CHEMBL30821 109961 0 None - 1 Human 7.1 pIC50 = 7.1 Binding
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 726 14 6 9 3.1 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCC(=O)NCCSCc3csc(N=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
44327455 114122 0 None - 0 Mouse 7.1 pIC50 = 7.1 Binding
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 585 12 3 4 6.0 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCCC(=O)O)CCc1ccccc1 10.1016/S0960-894X(01)80769-1
CHEMBL317626 114122 0 None - 0 Mouse 7.1 pIC50 = 7.1 Binding
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 585 12 3 4 6.0 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCCC(=O)O)CCc1ccccc1 10.1016/S0960-894X(01)80769-1
CHEMBL34916 218496 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cellsBinding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cells
ChEMBL None None None CCS[C@@H]1CCN(C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(C)=O)[C@@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00001a019
44349070 171270 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Concentration required to inhibit by 50% the specific binding of [3H]pentagastrin to Cholecystokinin type B receptor in rabbit gastric glandConcentration required to inhibit by 50% the specific binding of [3H]pentagastrin to Cholecystokinin type B receptor in rabbit gastric gland
ChEMBL 421 7 3 4 3.0 O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NN1CCC2(CCCC2)CC1 10.1021/jm00079a003
CHEMBL421438 171270 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Concentration required to inhibit by 50% the specific binding of [3H]pentagastrin to Cholecystokinin type B receptor in rabbit gastric glandConcentration required to inhibit by 50% the specific binding of [3H]pentagastrin to Cholecystokinin type B receptor in rabbit gastric gland
ChEMBL 421 7 3 4 3.0 O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NN1CCC2(CCCC2)CC1 10.1021/jm00079a003
14208241 74525 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 421 3 1 3 4.0 CN1C(=O)[C@@H](NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL1907852 74525 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 421 3 1 3 4.0 CN1C(=O)[C@@H](NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
14208269 84601 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 447 3 1 3 4.0 CN1C(=O)[C@@H](NC(=O)c2ccc(Br)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
CHEMBL2092869 84601 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 447 3 1 3 4.0 CN1C(=O)[C@@H](NC(=O)c2ccc(Br)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
44349064 23292 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 435 7 3 4 3.4 O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NN1CCC2(CCCCC2)CC1 10.1021/jm00079a003
CHEMBL123684 23292 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 435 7 3 4 3.4 O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NN1CCC2(CCCCC2)CC1 10.1021/jm00079a003
44348870 121606 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 452 7 3 5 3.3 O=C(O)CCC(NC(=O)c1cnc2ccccc2c1)C(=O)NN1CCC2(CCCCC2)CC1 10.1021/jm00079a003
CHEMBL334171 121606 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 452 7 3 5 3.3 O=C(O)CCC(NC(=O)c1cnc2ccccc2c1)C(=O)NN1CCC2(CCCCC2)CC1 10.1021/jm00079a003
44349336 171293 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 455 7 3 4 3.6 O=C(O)CCC(NC(=O)c1cccc(Cl)c1Cl)C(=O)NN1CCC2(CCCC2)CC1 10.1021/jm00079a003
CHEMBL421474 171293 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 455 7 3 4 3.6 O=C(O)CCC(NC(=O)c1cccc(Cl)c1Cl)C(=O)NN1CCC2(CCCC2)CC1 10.1021/jm00079a003
44280200 107601 0 None - 1 Mouse 6.1 pIC50 = 6.1 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 785 18 4 7 6.6 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL29331 107601 0 None - 1 Mouse 6.1 pIC50 = 6.1 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 785 18 4 7 6.6 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 10.1016/S0960-894X(96)00248-X
5279366 110938 1 None - 0 Human 5.1 pIC50 = 5.1 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 401 4 2 4 4.0 CSc1ccc(C(=O)NC2N=C(c3ccccc3)c3ccccc3NC2=O)cc1 10.1021/jm00120a002
CHEMBL309575 110938 1 None - 0 Human 5.1 pIC50 = 5.1 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 401 4 2 4 4.0 CSc1ccc(C(=O)NC2N=C(c3ccccc3)c3ccccc3NC2=O)cc1 10.1021/jm00120a002
15104601 177208 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 486 13 3 2 6.2 CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cc2ccccc2[nH]1 10.1021/jm00116a002
CHEMBL444847 177208 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 486 13 3 2 6.2 CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cc2ccccc2[nH]1 10.1021/jm00116a002
44349073 23329 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 395 7 3 4 2.5 CC1(C)CCN(NC(=O)C(CCC(=O)O)NC(=O)c2cccc(Cl)c2)CC1 10.1021/jm00079a003
CHEMBL123785 23329 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 395 7 3 4 2.5 CC1(C)CCN(NC(=O)C(CCC(=O)O)NC(=O)c2cccc(Cl)c2)CC1 10.1021/jm00079a003
14208261 110464 0 None - 0 Human 4.1 pIC50 = 4.1 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 397 5 2 3 4.2 CCCc1ccc(C(=O)NC2N=C(c3ccccc3)c3ccccc3NC2=O)cc1 10.1021/jm00120a002
CHEMBL308756 110464 0 None - 0 Human 4.1 pIC50 = 4.1 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 397 5 2 3 4.2 CCCc1ccc(C(=O)NC2N=C(c3ccccc3)c3ccccc3NC2=O)cc1 10.1021/jm00120a002
44379640 64360 0 None - 0 Mouse 5.1 pIC50 = 5.1 Binding
Inhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 522 6 2 5 5.8 CC(C)Oc1cccc(-n2c(C/N=C(\S)Nc3ccc(Br)cc3)nc3ccccc3c2=O)c1 10.1016/S0960-894X(97)00108-X
CHEMBL166737 64360 0 None - 0 Mouse 5.1 pIC50 = 5.1 Binding
Inhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 522 6 2 5 5.8 CC(C)Oc1cccc(-n2c(C/N=C(\S)Nc3ccc(Br)cc3)nc3ccccc3c2=O)c1 10.1016/S0960-894X(97)00108-X
4355450 142705 50 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of [125I]-labeled CCK-8 sulfate binding to Cholecystokinin type B receptor in guinea pig brain membranesInhibition of [125I]-labeled CCK-8 sulfate binding to Cholecystokinin type B receptor in guinea pig brain membranes
ChEMBL 501 6 1 4 6.2 CC(C)Oc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
CHEMBL37312 142705 50 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of [125I]-labeled CCK-8 sulfate binding to Cholecystokinin type B receptor in guinea pig brain membranesInhibition of [125I]-labeled CCK-8 sulfate binding to Cholecystokinin type B receptor in guinea pig brain membranes
ChEMBL 501 6 1 4 6.2 CC(C)Oc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
10070677 168503 15 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 418 3 2 3 4.3 CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL41361 168503 15 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 418 3 2 3 4.3 CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
44382244 65969 0 None - 0 Mouse 6.1 pIC50 = 6.1 Binding
Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 618 11 4 4 6.4 O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1)Nc1ccccc1 10.1016/S0960-894X(00)80687-3
CHEMBL170129 65969 0 None - 0 Mouse 6.1 pIC50 = 6.1 Binding
Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 618 11 4 4 6.4 O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1)Nc1ccccc1 10.1016/S0960-894X(00)80687-3
44334338 115690 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 547 9 2 5 4.2 Cc1cccc(NC(=O)N[C@H](CS(=O)(=O)Cc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
CHEMBL321107 115690 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 547 9 2 5 4.2 Cc1cccc(NC(=O)N[C@H](CS(=O)(=O)Cc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
44349383 23539 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Concentration required to inhibit by 50% the specific binding of [3H]pentagastrin to Cholecystokinin type B receptor in rabbit gastric glandConcentration required to inhibit by 50% the specific binding of [3H]pentagastrin to Cholecystokinin type B receptor in rabbit gastric gland
ChEMBL 480 9 3 3 4.7 O=C(O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)NCCC12CC3CC(CC(C3)C1)C2 10.1021/jm00079a003
CHEMBL124396 23539 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Concentration required to inhibit by 50% the specific binding of [3H]pentagastrin to Cholecystokinin type B receptor in rabbit gastric glandConcentration required to inhibit by 50% the specific binding of [3H]pentagastrin to Cholecystokinin type B receptor in rabbit gastric gland
ChEMBL 480 9 3 3 4.7 O=C(O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)NCCC12CC3CC(CC(C3)C1)C2 10.1021/jm00079a003
44348869 23179 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 407 7 3 4 2.6 O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NN1CCC2(CCCC2)C1 10.1021/jm00079a003
CHEMBL123089 23179 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 407 7 3 4 2.6 O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NN1CCC2(CCCC2)C1 10.1021/jm00079a003
44377487 126939 0 None - 0 Human 4.1 pIC50 = 4.1 Binding
In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.
ChEMBL 691 22 6 7 3.3 CCCCOC(=O)CCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCCC)NC(=O)[C@H](CC(=O)O)NC(=O)CCc1ccccc1 10.1021/jm00388a002
CHEMBL351531 126939 0 None - 0 Human 4.1 pIC50 = 4.1 Binding
In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.
ChEMBL 691 22 6 7 3.3 CCCCOC(=O)CCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCCC)NC(=O)[C@H](CC(=O)O)NC(=O)CCc1ccccc1 10.1021/jm00388a002
10074366 127376 0 None - 0 Mouse 6.1 pIC50 = 6.1 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 9 4 4 4.5 C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
CHEMBL3349028 127376 0 None - 0 Mouse 6.1 pIC50 = 6.1 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 9 4 4 4.5 C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
CHEMBL3545866 127376 0 None - 0 Mouse 6.1 pIC50 = 6.1 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 9 4 4 4.5 C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
44386584 173142 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.
ChEMBL 573 8 4 5 3.2 CC(C)(C)OC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)[C@](Cc3ccccc3)(C(N)=O)C[C@H]12 10.1016/0960-894X(96)00160-6
CHEMBL427492 173142 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.
ChEMBL 573 8 4 5 3.2 CC(C)(C)OC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)[C@](Cc3ccccc3)(C(N)=O)C[C@H]12 10.1016/0960-894X(96)00160-6
136794946 113389 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL 857 21 9 10 3.2 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1[N+](=O)[O-])C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm960509y
15689731 113389 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL 857 21 9 10 3.2 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1[N+](=O)[O-])C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm960509y
CHEMBL3142903 113389 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL 857 21 9 10 3.2 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1[N+](=O)[O-])C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm960509y
CHEMBL355778 218519 0 None - 0 Mouse 5.1 pIC50 = 5.1 Binding
Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N1C[C@H](CCc2ccccc2)NC(=O)[C@@H]1CC(=O)O 10.1016/S0960-894X(01)80253-5
14208247 211430 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 465 5 2 4 3.5 O=C(O)CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL73621 211430 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 465 5 2 4 3.5 O=C(O)CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
14208245 211538 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 389 3 2 3 3.9 O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccc(Cl)cc1 10.1021/jm00120a002
CHEMBL74580 211538 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 389 3 2 3 3.9 O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccc(Cl)cc1 10.1021/jm00120a002
44382243 66296 0 None - 0 Mouse 5.1 pIC50 = 5.1 Binding
Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 632 12 4 4 6.1 O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1)NCc1ccccc1 10.1016/S0960-894X(00)80687-3
CHEMBL171562 66296 0 None - 0 Mouse 5.1 pIC50 = 5.1 Binding
Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 632 12 4 4 6.1 O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1)NCc1ccccc1 10.1016/S0960-894X(00)80687-3
14843033 143733 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Inhibition of [125I]-labeled gastrin binding to gastrin/cholecystokinin type B receptorInhibition of [125I]-labeled gastrin binding to gastrin/cholecystokinin type B receptor
ChEMBL 433 4 1 3 5.7 O=c1c2ccccc2nc(CCc2c[nH]c3ccccc23)n1-c1cccc(C(F)(F)F)c1 10.1021/jm00108a040
CHEMBL37439 143733 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Inhibition of [125I]-labeled gastrin binding to gastrin/cholecystokinin type B receptorInhibition of [125I]-labeled gastrin binding to gastrin/cholecystokinin type B receptor
ChEMBL 433 4 1 3 5.7 O=c1c2ccccc2nc(CCc2c[nH]c3ccccc23)n1-c1cccc(C(F)(F)F)c1 10.1021/jm00108a040
CHEMBL286843 106798 0 None - 0 Mouse 6.1 pIC50 = 6.1 Binding
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 541 8 3 4 7.2 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C1NC=C(CCc2ccccc2)S1 10.1021/jm00086a017
10673570 36929 0 None - 0 Mouse 7.1 pIC50 = 7.1 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 521 7 4 4 4.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1(C(=O)O)CCCCC1 10.1021/jm970065l
CHEMBL139001 36929 0 None - 0 Mouse 7.1 pIC50 = 7.1 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 521 7 4 4 4.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1(C(=O)O)CCCCC1 10.1021/jm970065l
14991575 107561 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 852 20 10 9 3.0 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1cc2cc(O)ccc2[nH]1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL293026 107561 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 852 20 10 9 3.0 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1cc2cc(O)ccc2[nH]1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
44349082 24547 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Concentration required to inhibit by 50% the specific binding of [3H]pentagastrin to Cholecystokinin type B receptor in rabbit gastric glandConcentration required to inhibit by 50% the specific binding of [3H]pentagastrin to Cholecystokinin type B receptor in rabbit gastric gland
ChEMBL 446 9 3 3 4.0 O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NCCC12CC3CC(CC(C3)C1)C2 10.1021/jm00079a003
CHEMBL125874 24547 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Concentration required to inhibit by 50% the specific binding of [3H]pentagastrin to Cholecystokinin type B receptor in rabbit gastric glandConcentration required to inhibit by 50% the specific binding of [3H]pentagastrin to Cholecystokinin type B receptor in rabbit gastric gland
ChEMBL 446 9 3 3 4.0 O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NCCC12CC3CC(CC(C3)C1)C2 10.1021/jm00079a003
10698109 114073 0 None -5 2 Human 6.1 pIC50 = 6.1 Binding
Binding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligandBinding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligand
ChEMBL 560 8 1 4 5.8 CC(C)N(C(=O)CN1C(=O)C(CC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/jm960205b
CHEMBL317181 114073 0 None -5 2 Human 6.1 pIC50 = 6.1 Binding
Binding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligandBinding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligand
ChEMBL 560 8 1 4 5.8 CC(C)N(C(=O)CN1C(=O)C(CC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/jm960205b
10698109 114073 0 None -5 2 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]Bolton-Hunter CCK8 from human Cholecystokinin B receptor expressed in CHO-K1 cells by competitive radioligand binding assayDisplacement of [125I]Bolton-Hunter CCK8 from human Cholecystokinin B receptor expressed in CHO-K1 cells by competitive radioligand binding assay
ChEMBL 560 8 1 4 5.8 CC(C)N(C(=O)CN1C(=O)C(CC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/acs.jmedchem.0c00829
CHEMBL317181 114073 0 None -5 2 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]Bolton-Hunter CCK8 from human Cholecystokinin B receptor expressed in CHO-K1 cells by competitive radioligand binding assayDisplacement of [125I]Bolton-Hunter CCK8 from human Cholecystokinin B receptor expressed in CHO-K1 cells by competitive radioligand binding assay
ChEMBL 560 8 1 4 5.8 CC(C)N(C(=O)CN1C(=O)C(CC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/acs.jmedchem.0c00829
10031013 213263 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity against human Cholecystokinin type B receptorBinding affinity against human Cholecystokinin type B receptor
ChEMBL 574 8 1 4 6.2 CC(C)N(C(=O)CN1C(=O)C(C)(CC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/jm960249k
CHEMBL88239 213263 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity against human Cholecystokinin type B receptorBinding affinity against human Cholecystokinin type B receptor
ChEMBL 574 8 1 4 6.2 CC(C)N(C(=O)CN1C(=O)C(C)(CC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/jm960249k
10031013 213263 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligandBinding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligand
ChEMBL 574 8 1 4 6.2 CC(C)N(C(=O)CN1C(=O)C(C)(CC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/jm960205b
CHEMBL88239 213263 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligandBinding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligand
ChEMBL 574 8 1 4 6.2 CC(C)N(C(=O)CN1C(=O)C(C)(CC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/jm960205b
155530671 178341 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1627 65 14 19 4.1 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](CCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)NC(=O)Cc1ccc(O)cc1)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4464703 178341 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1627 65 14 19 4.1 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](CCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)NC(=O)Cc1ccc(O)cc1)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
10031013 213263 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Displacement of [125I]Bolton-Hunter CCK8 from human Cholecystokinin B receptor expressed in CHO-K1 cells by competitive radioligand binding assayDisplacement of [125I]Bolton-Hunter CCK8 from human Cholecystokinin B receptor expressed in CHO-K1 cells by competitive radioligand binding assay
ChEMBL 574 8 1 4 6.2 CC(C)N(C(=O)CN1C(=O)C(C)(CC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/acs.jmedchem.0c00829
CHEMBL88239 213263 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Displacement of [125I]Bolton-Hunter CCK8 from human Cholecystokinin B receptor expressed in CHO-K1 cells by competitive radioligand binding assayDisplacement of [125I]Bolton-Hunter CCK8 from human Cholecystokinin B receptor expressed in CHO-K1 cells by competitive radioligand binding assay
ChEMBL 574 8 1 4 6.2 CC(C)N(C(=O)CN1C(=O)C(C)(CC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/acs.jmedchem.0c00829
14991580 107484 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 829 21 8 9 3.3 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C/c1cccs1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL292490 107484 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 829 21 8 9 3.3 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C/c1cccs1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
44280598 107269 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 694 12 4 5 6.2 O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2ccccc12 10.1021/jm950372w
CHEMBL291001 107269 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 694 12 4 5 6.2 O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2ccccc12 10.1021/jm950372w
15689725 113379 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 880 20 9 8 4.3 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccc(C(F)(F)F)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
CHEMBL3142704 113379 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 880 20 9 8 4.3 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccc(C(F)(F)F)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
44366587 50466 0 None - 0 Mouse 5.1 pIC50 = 5.1 Binding
Binding affinity towards CCK-B receptor in mouse cerebral cortex using [125I]Bolton-Hunter CCK-8 as radioligand; Value ranges from 7.8-9.3 uMBinding affinity towards CCK-B receptor in mouse cerebral cortex using [125I]Bolton-Hunter CCK-8 as radioligand; Value ranges from 7.8-9.3 uM
ChEMBL 554 10 0 8 7.2 CCOP(=O)(OCC)OC1=CCN(Cc2ccccc2)CC1Cc1cn(C(=O)OC(C)(C)C)c2ccccc12 10.1016/0960-894X(94)80030-8
CHEMBL151022 50466 0 None - 0 Mouse 5.1 pIC50 = 5.1 Binding
Binding affinity towards CCK-B receptor in mouse cerebral cortex using [125I]Bolton-Hunter CCK-8 as radioligand; Value ranges from 7.8-9.3 uMBinding affinity towards CCK-B receptor in mouse cerebral cortex using [125I]Bolton-Hunter CCK-8 as radioligand; Value ranges from 7.8-9.3 uM
ChEMBL 554 10 0 8 7.2 CCOP(=O)(OCC)OC1=CCN(Cc2ccccc2)CC1Cc1cn(C(=O)OC(C)(C)C)c2ccccc12 10.1016/0960-894X(94)80030-8
10165354 28918 0 None - 0 Mouse 6.1 pIC50 = 6.1 Binding
Evaluated for in vitro binding affinity towards cholecystokinin-B (CCK-B) receptor in mouse cerebral cortex using [125I]bolton hunter CCK-26-33 as radioligand; 365-1590Evaluated for in vitro binding affinity towards cholecystokinin-B (CCK-B) receptor in mouse cerebral cortex using [125I]bolton hunter CCK-26-33 as radioligand; 365-1590
ChEMBL 529 9 4 4 4.7 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC(CO)Cc1ccccc1 10.1016/S0960-894X(00)80156-0
CHEMBL132233 28918 0 None - 0 Mouse 6.1 pIC50 = 6.1 Binding
Evaluated for in vitro binding affinity towards cholecystokinin-B (CCK-B) receptor in mouse cerebral cortex using [125I]bolton hunter CCK-26-33 as radioligand; 365-1590Evaluated for in vitro binding affinity towards cholecystokinin-B (CCK-B) receptor in mouse cerebral cortex using [125I]bolton hunter CCK-26-33 as radioligand; 365-1590
ChEMBL 529 9 4 4 4.7 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC(CO)Cc1ccccc1 10.1016/S0960-894X(00)80156-0
11741582 34734 9 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 398 4 2 3 3.3 CN1C(=O)C(NC(=O)NCc2ccccc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL137213 34734 9 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 398 4 2 3 3.3 CN1C(=O)C(NC(=O)NCc2ccccc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
44370461 126344 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 488 15 2 4 4.8 CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)N1CCCC1)NC(=O)Nc1cccc(OC)c1 10.1021/jm00164a020
CHEMBL346070 126344 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 488 15 2 4 4.8 CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)N1CCCC1)NC(=O)Nc1cccc(OC)c1 10.1021/jm00164a020
19766170 65931 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 383 5 3 4 2.2 COc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)O)C2=O)c1 10.1016/S0960-894X(00)80683-6
CHEMBL169931 65931 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 383 5 3 4 2.2 COc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)O)C2=O)c1 10.1016/S0960-894X(00)80683-6
44381609 135890 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
Inhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptorInhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptor
ChEMBL 610 15 6 7 2.5 N#C[C@H](N[C@H](CC(=O)NC(Cc1ccccc1)C(N)=O)C(=O)O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1 10.1016/S0960-894X(97)00107-8
CHEMBL367057 135890 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
Inhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptorInhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptor
ChEMBL 610 15 6 7 2.5 N#C[C@H](N[C@H](CC(=O)NC(Cc1ccccc1)C(N)=O)C(=O)O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1 10.1016/S0960-894X(97)00107-8
14991578 168494 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 824 21 8 9 2.7 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C/c1cccnc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL413548 168494 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 824 21 8 9 2.7 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C/c1cccnc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
44329343 119107 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 556 7 3 4 5.6 COc1ccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)NC(C)(C)C)C2=O)cc1 10.1016/S0960-894X(01)80832-5
CHEMBL329286 119107 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 556 7 3 4 5.6 COc1ccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)NC(C)(C)C)C2=O)cc1 10.1016/S0960-894X(01)80832-5
155537344 179097 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1848 72 16 22 3.6 CCCC[C@H](NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4475304 179097 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1848 72 16 22 3.6 CCCC[C@H](NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
44303481 107475 0 None - 0 Mouse 6.1 pIC50 = 6.1 Binding
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 524 9 3 6 4.3 CC(=O)Nc1nc(CC(C)(NC(=O)OC2C3CC4CC(C3)CC2C4)C(=O)NCCc2ccccc2)cs1 10.1016/S0960-894X(97)00356-9
CHEMBL292422 107475 0 None - 0 Mouse 6.1 pIC50 = 6.1 Binding
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 524 9 3 6 4.3 CC(=O)Nc1nc(CC(C)(NC(=O)OC2C3CC4CC(C3)CC2C4)C(=O)NCCc2ccccc2)cs1 10.1016/S0960-894X(97)00356-9
44382057 127113 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 420 4 2 3 3.1 Cc1cccc(NC(=O)N[C@H]2CCc3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 10.1016/S0960-894X(00)80683-6
CHEMBL352939 127113 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 420 4 2 3 3.1 Cc1cccc(NC(=O)N[C@H]2CCc3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 10.1016/S0960-894X(00)80683-6
44379911 65647 0 None - 0 Mouse 6.1 pIC50 = 6.1 Binding
Inhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 442 6 2 5 4.8 Cc1cccc(NC(=O)NCc2nc3ccccc3c(=O)n2-c2cccc(OC(C)C)c2)c1 10.1016/S0960-894X(97)00108-X
CHEMBL168875 65647 0 None - 0 Mouse 6.1 pIC50 = 6.1 Binding
Inhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 442 6 2 5 4.8 Cc1cccc(NC(=O)NCc2nc3ccccc3c(=O)n2-c2cccc(OC(C)C)c2)c1 10.1016/S0960-894X(97)00108-X
10553207 215051 0 None - 0 Mouse 7.1 pIC50 = 7.1 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 492 6 2 6 4.7 CC(C)Oc1cccc(-n2c(NNC(=O)c3ccc(Br)cc3)nc3ccccc3c2=O)c1 10.1021/jm970373j
CHEMBL9888 215051 0 None - 0 Mouse 7.1 pIC50 = 7.1 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 492 6 2 6 4.7 CC(C)Oc1cccc(-n2c(NNC(=O)c3ccc(Br)cc3)nc3ccccc3c2=O)c1 10.1021/jm970373j
CHEMBL2112689 216028 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity towards Cholecystokinin type B receptor was determined in guinea pig cortex using [3H]SNF8702 as radioligandBinding affinity towards Cholecystokinin type B receptor was determined in guinea pig cortex using [3H]SNF8702 as radioligand
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@@H](NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)[C@@H](C)c1c[nH]c2ccccc12 10.1021/jm960078j
14843047 126279 0 None - 0 Mouse 7.1 pIC50 = 7.1 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 487 6 1 4 5.8 CCOc1ccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)cc1 10.1021/jm00108a040
CHEMBL34547 126279 0 None - 0 Mouse 7.1 pIC50 = 7.1 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 487 6 1 4 5.8 CCOc1ccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)cc1 10.1021/jm00108a040
44333312 11343 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortexDisplacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortex
ChEMBL 406 2 3 5 1.8 Cc1cccc(NC(=O)NC2N=C(N3CCNCC3)c3ccccc3N(C)C2=O)c1 10.1016/0960-894X(95)00530-0
CHEMBL102537 11343 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortexDisplacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortex
ChEMBL 406 2 3 5 1.8 Cc1cccc(NC(=O)NC2N=C(N3CCNCC3)c3ccccc3N(C)C2=O)c1 10.1016/0960-894X(95)00530-0
44152863 127141 7 None - 0 Mouse 6.1 pIC50 = 6.1 Binding
The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in mouse brain at a pH of 7.4The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in mouse brain at a pH of 7.4
ChEMBL 475 3 2 2 5.9 O=C1NN(C(=S)Nc2ccc(Cl)c(C(F)(F)F)c2)C(c2ccccc2)C1c1ccccc1 10.1016/S0960-894X(00)80684-8
CHEMBL353189 127141 7 None - 0 Mouse 6.1 pIC50 = 6.1 Binding
The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in mouse brain at a pH of 7.4The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in mouse brain at a pH of 7.4
ChEMBL 475 3 2 2 5.9 O=C1NN(C(=S)Nc2ccc(Cl)c(C(F)(F)F)c2)C(c2ccccc2)C1c1ccccc1 10.1016/S0960-894X(00)80684-8
15673150 92769 0 None - 0 Mouse 7.1 pIC50 = 7.1 Binding
The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the mouse cerebral cortex (CCK-B);value ranges from 63 to 170The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the mouse cerebral cortex (CCK-B);value ranges from 63 to 170
ChEMBL 681 12 5 5 5.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCNC(=O)C(F)(F)F)c1ccccc1 10.1016/S0960-894X(00)80652-6
CHEMBL2304154 92769 0 None - 0 Mouse 7.1 pIC50 = 7.1 Binding
The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the mouse cerebral cortex (CCK-B);value ranges from 63 to 170The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the mouse cerebral cortex (CCK-B);value ranges from 63 to 170
ChEMBL 681 12 5 5 5.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCNC(=O)C(F)(F)F)c1ccccc1 10.1016/S0960-894X(00)80652-6
44382749 66483 0 None - 0 Mouse 5.1 pIC50 = 5.1 Binding
Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)
ChEMBL 532 11 4 4 3.0 CC(C)C[C@H](NC(=O)CCc1c[nH]c2ccccc12)C(=O)N1C[C@H](Cc2ccccc2)NC(=O)[C@@H]1CC(=O)O 10.1016/S0960-894X(01)80253-5
CHEMBL172354 66483 0 None - 0 Mouse 5.1 pIC50 = 5.1 Binding
Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)
ChEMBL 532 11 4 4 3.0 CC(C)C[C@H](NC(=O)CCc1c[nH]c2ccccc12)C(=O)N1C[C@H](Cc2ccccc2)NC(=O)[C@@H]1CC(=O)O 10.1016/S0960-894X(01)80253-5
10580108 11883 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligandBinding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligand
ChEMBL 650 10 1 4 7.4 CC(C)N(C(=O)CN1C(=O)C(CC(=O)Nc2ccccc2)(Cc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/jm960205b
CHEMBL105619 11883 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligandBinding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligand
ChEMBL 650 10 1 4 7.4 CC(C)N(C(=O)CN1C(=O)C(CC(=O)Nc2ccccc2)(Cc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/jm960205b
44300888 107568 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 580 6 4 6 4.5 Cc1ccc([C@H]2C[C@@H](NC(=O)Nc3cccc(-c4nn[nH]n4)c3)C(=O)N(CC(=O)NC(C)(C)C)c3cc(C)ccc32)cc1 10.1016/0960-894X(95)00327-P
CHEMBL293107 107568 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 580 6 4 6 4.5 Cc1ccc([C@H]2C[C@@H](NC(=O)Nc3cccc(-c4nn[nH]n4)c3)C(=O)N(CC(=O)NC(C)(C)C)c3cc(C)ccc32)cc1 10.1016/0960-894X(95)00327-P
73349872 95976 1 None - 0 Rat 8.1 pIC50 = 8.1 Binding
Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.
ChEMBL 616 12 5 5 5.2 CC1(C)[C@H]2CC[C@@]1(C)[C@H](OC(=O)N[C@](C)(Cc1c[nH]c3ccccc13)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1)C2 10.1016/0960-894X(96)00160-6
CHEMBL2367718 95976 1 None - 0 Rat 8.1 pIC50 = 8.1 Binding
Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.
ChEMBL 616 12 5 5 5.2 CC1(C)[C@H]2CC[C@@]1(C)[C@H](OC(=O)N[C@](C)(Cc1c[nH]c3ccccc13)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1)C2 10.1016/0960-894X(96)00160-6
CHEMBL2367719 95976 1 None - 0 Rat 8.1 pIC50 = 8.1 Binding
Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.
ChEMBL 616 12 5 5 5.2 CC1(C)[C@H]2CC[C@@]1(C)[C@H](OC(=O)N[C@](C)(Cc1c[nH]c3ccccc13)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1)C2 10.1016/0960-894X(96)00160-6
44348637 171289 0 None - 0 Bovine 8.1 pIC50 = 8.1 Binding
Inhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatumInhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatum
ChEMBL 966 27 11 11 1.0 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCNC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00099a005
CHEMBL421471 171289 0 None - 0 Bovine 8.1 pIC50 = 8.1 Binding
Inhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatumInhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatum
ChEMBL 966 27 11 11 1.0 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCNC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00099a005
44281204 106626 0 None - 1 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against gastrin receptor.Inhibitory activity against gastrin receptor.
ChEMBL 871 18 4 10 5.5 CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCCCN3CCN(C(=O)CNCCCOc4cccc(CN5CCCCC5)c4)CC3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
CHEMBL285719 106626 0 None - 1 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against gastrin receptor.Inhibitory activity against gastrin receptor.
ChEMBL 871 18 4 10 5.5 CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCCCN3CCN(C(=O)CNCCCOc4cccc(CN5CCCCC5)c4)CC3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
44265968 213567 0 None - 0 Mouse 8.0 pIC50 = 8.0 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 501 6 1 4 6.2 CC(C)Oc1cccc(-n2c(CCc3c[nH]c4cc(Br)ccc34)nc3ccccc3c2=O)c1 10.1021/jm970373j
CHEMBL9026 213567 0 None - 0 Mouse 8.0 pIC50 = 8.0 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 501 6 1 4 6.2 CC(C)Oc1cccc(-n2c(CCc3c[nH]c4cc(Br)ccc34)nc3ccccc3c2=O)c1 10.1021/jm970373j
4355450 142705 50 None - 0 Mouse 8.0 pIC50 = 8.0 Binding
Evaluated for inhibition of [125I]CCK-8S binding to cholecystokinin CCK-B receptor from mouse brain membranes at a concentration of 10 uM (in vitro)Evaluated for inhibition of [125I]CCK-8S binding to cholecystokinin CCK-B receptor from mouse brain membranes at a concentration of 10 uM (in vitro)
ChEMBL 501 6 1 4 6.2 CC(C)Oc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00092a003
CHEMBL37312 142705 50 None - 0 Mouse 8.0 pIC50 = 8.0 Binding
Evaluated for inhibition of [125I]CCK-8S binding to cholecystokinin CCK-B receptor from mouse brain membranes at a concentration of 10 uM (in vitro)Evaluated for inhibition of [125I]CCK-8S binding to cholecystokinin CCK-B receptor from mouse brain membranes at a concentration of 10 uM (in vitro)
ChEMBL 501 6 1 4 6.2 CC(C)Oc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00092a003
5311347 114133 3 None - 0 Mouse 8.0 pIC50 = 8.0 Binding
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 557 10 4 4 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@@H](CC(=O)O)Cc1ccccc1 10.1016/S0960-894X(01)80769-1
CHEMBL317675 114133 3 None - 0 Mouse 8.0 pIC50 = 8.0 Binding
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 557 10 4 4 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@@H](CC(=O)O)Cc1ccccc1 10.1016/S0960-894X(01)80769-1
4355450 142705 50 None - 0 Mouse 8.0 pIC50 = 8.0 Binding
Inhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 501 6 1 4 6.2 CC(C)Oc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1016/S0960-894X(97)00108-X
CHEMBL37312 142705 50 None - 0 Mouse 8.0 pIC50 = 8.0 Binding
Inhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 501 6 1 4 6.2 CC(C)Oc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1016/S0960-894X(97)00108-X
4355450 142705 50 None - 0 Mouse 8.0 pIC50 = 8.0 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 501 6 1 4 6.2 CC(C)Oc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
CHEMBL37312 142705 50 None - 0 Mouse 8.0 pIC50 = 8.0 Binding
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 501 6 1 4 6.2 CC(C)Oc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
5311347 39800 3 None - 1 Mouse 8.0 pIC50 = 8.0 Binding
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 557 10 4 4 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccccc1 10.1016/S0960-894X(00)80685-X
CHEMBL141630 39800 3 None - 1 Mouse 8.0 pIC50 = 8.0 Binding
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 557 10 4 4 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccccc1 10.1016/S0960-894X(00)80685-X
5311347 114133 3 None - 0 Mouse 8.0 pIC50 = 8.0 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 557 10 4 4 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@@H](CC(=O)O)Cc1ccccc1 10.1021/jm00057a005
CHEMBL317675 114133 3 None - 0 Mouse 8.0 pIC50 = 8.0 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 557 10 4 4 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@@H](CC(=O)O)Cc1ccccc1 10.1021/jm00057a005
10074366 127376 0 None - 0 Mouse 8.0 pIC50 = 8.0 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 9 4 4 4.5 C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
CHEMBL3349028 127376 0 None - 0 Mouse 8.0 pIC50 = 8.0 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 9 4 4 4.5 C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
CHEMBL3545866 127376 0 None - 0 Mouse 8.0 pIC50 = 8.0 Binding
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 9 4 4 4.5 C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
5311347 39800 3 None - 1 Mouse 8.0 pIC50 = 8.0 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 557 10 4 4 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccccc1 10.1021/jm970065l
CHEMBL141630 39800 3 None - 1 Mouse 8.0 pIC50 = 8.0 Binding
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 557 10 4 4 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccccc1 10.1021/jm970065l
9823890 33707 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 428 4 3 4 3.3 CN1C(=O)C(NC(=O)Nc2cccc(C(=O)O)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL136412 33707 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 428 4 3 4 3.3 CN1C(=O)C(NC(=O)Nc2cccc(C(=O)O)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
10412837 34396 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 479 5 3 5 4.0 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(Cc3n[nH]c(C)n3)C2=O)c1 10.1021/jm00078a018
CHEMBL136975 34396 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 479 5 3 5 4.0 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(Cc3n[nH]c(C)n3)C2=O)c1 10.1021/jm00078a018
44357031 35471 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 585 8 2 9 3.1 COC(=O)[C@H]1CCCN1OC(=O)CN1C(=O)C(NC(=O)Nc2cccc(OC)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL137779 35471 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 585 8 2 9 3.1 COC(=O)[C@H]1CCCN1OC(=O)CN1C(=O)C(NC(=O)Nc2cccc(OC)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
145980742 173310 0 None - 0 Rat 8.0 pIC50 = 8.0 Binding
Displacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting methodDisplacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting method
ChEMBL 465 6 3 6 4.8 CCOc1ccc(NC(=S)NNc2nc3ccccc3c(=O)n2-c2ccc(Cl)cc2)cc1 10.1039/C7MD00171A
CHEMBL4279247 173310 0 None - 0 Rat 8.0 pIC50 = 8.0 Binding
Displacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting methodDisplacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting method
ChEMBL 465 6 3 6 4.8 CCOc1ccc(NC(=S)NNc2nc3ccccc3c(=O)n2-c2ccc(Cl)cc2)cc1 10.1039/C7MD00171A
21467078 11197 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortexDisplacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortex
ChEMBL 448 4 2 5 2.9 CCCN1C(=O)C(NC(=O)Nc2cccc(C)c2)N=C(N2CCN(C)CC2)c2ccccc21 10.1016/0960-894X(95)00530-0
CHEMBL101528 11197 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortexDisplacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortex
ChEMBL 448 4 2 5 2.9 CCCN1C(=O)C(NC(=O)Nc2cccc(C)c2)N=C(N2CCN(C)CC2)c2ccccc21 10.1016/0960-894X(95)00530-0
73349872 95976 1 None - 0 Rat 8.0 pIC50 = 8.0 Binding
Inhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenatesInhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenates
ChEMBL 616 12 5 5 5.2 CC1(C)[C@H]2CC[C@@]1(C)[C@H](OC(=O)N[C@](C)(Cc1c[nH]c3ccccc13)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1)C2 10.1021/jm0498755
CHEMBL2367718 95976 1 None - 0 Rat 8.0 pIC50 = 8.0 Binding
Inhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenatesInhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenates
ChEMBL 616 12 5 5 5.2 CC1(C)[C@H]2CC[C@@]1(C)[C@H](OC(=O)N[C@](C)(Cc1c[nH]c3ccccc13)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1)C2 10.1021/jm0498755
CHEMBL2367719 95976 1 None - 0 Rat 8.0 pIC50 = 8.0 Binding
Inhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenatesInhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenates
ChEMBL 616 12 5 5 5.2 CC1(C)[C@H]2CC[C@@]1(C)[C@H](OC(=O)N[C@](C)(Cc1c[nH]c3ccccc13)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1)C2 10.1021/jm0498755
10070679 34541 13 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 418 3 2 3 4.3 CN1C(=O)C(NC(=O)Nc2cccc(Cl)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL137066 34541 13 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 418 3 2 3 4.3 CN1C(=O)C(NC(=O)Nc2cccc(Cl)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
44377486 175047 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.
ChEMBL 678 16 7 7 2.5 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(=O)O)NC(=O)C(Cc1ccccc1)C(N)=O 10.1021/jm00388a002
CHEMBL433901 175047 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.
ChEMBL 678 16 7 7 2.5 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(=O)O)NC(=O)C(Cc1ccccc1)C(N)=O 10.1021/jm00388a002
44327698 214252 0 None - 0 Mouse 7.0 pIC50 = 7.0 Binding
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 572 10 2 6 4.7 COC(=O)CN(CCc1ccccn1)C(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1016/S0960-894X(01)80769-1
CHEMBL94298 214252 0 None - 0 Mouse 7.0 pIC50 = 7.0 Binding
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 572 10 2 6 4.7 COC(=O)CN(CCc1ccccn1)C(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1016/S0960-894X(01)80769-1
44349413 119884 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 410 12 3 3 4.0 CCC(CC)(CC)CCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 10.1021/jm00079a003
CHEMBL331413 119884 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 410 12 3 3 4.0 CCC(CC)(CC)CCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 10.1021/jm00079a003
44334337 11447 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 541 10 2 5 5.1 Cc1cccc(NC(=O)N[C@H](CCC(=O)OCc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
CHEMBL103276 11447 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 541 10 2 5 5.1 Cc1cccc(NC(=O)N[C@H](CCC(=O)OCc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
14208302 74519 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 412 3 1 4 3.3 CN1C(=O)[C@@H](NC(=O)c2ccc(C#N)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL1907847 74519 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 412 3 1 4 3.3 CN1C(=O)[C@@H](NC(=O)c2ccc(C#N)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
14994682 212839 0 None - 0 Mouse 5.0 pIC50 = 5.0 Binding
Evaluated for inhibition of [125I]CCK-8S binding to cholecystokinin CCK-B receptor from mouse brain membranes at a concentration of 10 uM (in vitro)Evaluated for inhibition of [125I]CCK-8S binding to cholecystokinin CCK-B receptor from mouse brain membranes at a concentration of 10 uM (in vitro)
ChEMBL 437 6 1 4 6.0 CC(C)Oc1cccc(-n2c(C(C)Cc3c[nH]c4ccccc34)nc3ccccc3c2=O)c1 10.1021/jm00092a003
CHEMBL85393 212839 0 None - 0 Mouse 5.0 pIC50 = 5.0 Binding
Evaluated for inhibition of [125I]CCK-8S binding to cholecystokinin CCK-B receptor from mouse brain membranes at a concentration of 10 uM (in vitro)Evaluated for inhibition of [125I]CCK-8S binding to cholecystokinin CCK-B receptor from mouse brain membranes at a concentration of 10 uM (in vitro)
ChEMBL 437 6 1 4 6.0 CC(C)Oc1cccc(-n2c(C(C)Cc3c[nH]c4ccccc34)nc3ccccc3c2=O)c1 10.1021/jm00092a003
44333997 115536 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 588 10 3 5 5.3 CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N1CCC(C(=O)c2ccccc2)CC1 10.1016/0960-894X(95)00537-3
CHEMBL320886 115536 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 588 10 3 5 5.3 CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N1CCC(C(=O)c2ccccc2)CC1 10.1016/0960-894X(95)00537-3
10644845 103768 0 None - 0 Mouse 6.0 pIC50 = 6.0 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 403 4 3 5 4.0 Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(F)c2)c1 10.1021/jm970373j
CHEMBL266523 103768 0 None - 0 Mouse 6.0 pIC50 = 6.0 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 403 4 3 5 4.0 Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(F)c2)c1 10.1021/jm970373j
CHEMBL2079550 215972 0 None - 0 Bovine 7.0 pIC50 = 7.0 Binding
Inhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranesInhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccc(C(F)(F)C(=O)O)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00107a037
10046475 122285 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 399 3 2 4 3.4 Cc1cccc(NC(=O)NC2N=C(c3cccnc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
CHEMBL335241 122285 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 399 3 2 4 3.4 Cc1cccc(NC(=O)NC2N=C(c3cccnc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
44279809 105743 0 None - 1 Mouse 7.0 pIC50 = 7.0 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 785 18 4 7 6.4 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
CHEMBL279778 105743 0 None - 1 Mouse 7.0 pIC50 = 7.0 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 785 18 4 7 6.4 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
44381820 127402 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
Inhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptorInhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptor
ChEMBL 689 18 7 8 2.8 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](C#N)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(97)00107-8
CHEMBL354631 127402 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
Inhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptorInhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptor
ChEMBL 689 18 7 8 2.8 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](C#N)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(97)00107-8
15104628 16777 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 534 10 2 5 4.6 CCOC(=O)CN(Cc1ccccc1)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cnc2ccccc2c1 10.1021/jm00116a002
CHEMBL114926 16777 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 534 10 2 5 4.6 CCOC(=O)CN(Cc1ccccc1)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cnc2ccccc2c1 10.1021/jm00116a002
15104621 118135 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 476 13 3 2 6.4 CCCCCN(CCCCC)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)Nc1ccc(C)cc1 10.1021/jm00116a002
CHEMBL326975 118135 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 476 13 3 2 6.4 CCCCCN(CCCCC)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)Nc1ccc(C)cc1 10.1021/jm00116a002
CHEMBL282175 106097 0 None - 1 Mouse 6.0 pIC50 = 6.0 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 769 16 6 11 4.6 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CCOC(=O)NCCCC(=O)NCCSCc3csc(C=C(N)N)n3)C2=O)c1 10.1016/S0960-894X(96)00249-1
44408483 175708 0 None -275 4 Human 6.0 pIC50 = 6.0 Binding
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1212 31 12 15 3.7 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@H](Cc1cn(C(=O)OC2C3CC4CC(C3)CC2C4)c2ccccc12)C(=O)O 10.1021/jm050851n
CHEMBL438739 175708 0 None -275 4 Human 6.0 pIC50 = 6.0 Binding
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1212 31 12 15 3.7 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@H](Cc1cn(C(=O)OC2C3CC4CC(C3)CC2C4)c2ccccc12)C(=O)O 10.1021/jm050851n
44408484 144286 0 None -18197 4 Human 5.0 pIC50 = 5.0 Binding
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1033 30 13 12 1.4 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm050851n
CHEMBL375412 144286 0 None -18197 4 Human 5.0 pIC50 = 5.0 Binding
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1033 30 13 12 1.4 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm050851n
44418924 163661 0 None -18620 4 Human 5.0 pIC50 = 5.0 Binding
Displacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1031 27 13 12 0.2 CCCC[C@H](NC(=O)[C@H](N)Cc1cc2ccccc2[nH]1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061268p
CHEMBL407198 163661 0 None -18620 4 Human 5.0 pIC50 = 5.0 Binding
Displacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1031 27 13 12 0.2 CCCC[C@H](NC(=O)[C@H](N)Cc1cc2ccccc2[nH]1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061268p
11714636 148016 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
Displacement of [3H]propionylCCK8 from rat cerebral cortex CCK2Displacement of [3H]propionylCCK8 from rat cerebral cortex CCK2
ChEMBL 717 10 6 6 3.7 CC(C)(C)OC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1C[C@@H]2c3[nH]c4ccccc4c3C[C@@H](C(=O)N[C@H](Cc3ccccc3)C(N)=O)N2C1=O 10.1021/jm050689o
CHEMBL382952 148016 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
Displacement of [3H]propionylCCK8 from rat cerebral cortex CCK2Displacement of [3H]propionylCCK8 from rat cerebral cortex CCK2
ChEMBL 717 10 6 6 3.7 CC(C)(C)OC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1C[C@@H]2c3[nH]c4ccccc4c3C[C@@H](C(=O)N[C@H](Cc3ccccc3)C(N)=O)N2C1=O 10.1021/jm050689o
44381851 127156 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
Inhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptorInhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptor
ChEMBL 723 20 7 8 3.2 CCCC[C@H](N[C@H](C#N)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(=O)N[C@@H](Cc1ccccc1)C(N)=O)C(=O)O 10.1016/S0960-894X(97)00107-8
CHEMBL353305 127156 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
Inhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptorInhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptor
ChEMBL 723 20 7 8 3.2 CCCC[C@H](N[C@H](C#N)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(=O)N[C@@H](Cc1ccccc1)C(N)=O)C(=O)O 10.1016/S0960-894X(97)00107-8
44281078 106519 0 None - 1 Mouse 7.0 pIC50 = 7.0 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 773 16 4 8 5.9 CN1C(=O)[C@H](NC(=O)Nc2cccc(CCOC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
CHEMBL284975 106519 0 None - 1 Mouse 7.0 pIC50 = 7.0 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 773 16 4 8 5.9 CN1C(=O)[C@H](NC(=O)Nc2cccc(CCOC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
CHEMBL172635 215633 0 None - 0 Mouse 5.0 pIC50 = 5.0 Binding
Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N1C[C@H](c2ccccc2)NC(=O)[C@@H]1CC(=O)O 10.1016/S0960-894X(01)80253-5
14208258 109733 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 373 3 2 3 3.4 O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccc(F)cc1 10.1021/jm00120a002
CHEMBL306394 109733 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 373 3 2 3 3.4 O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccc(F)cc1 10.1021/jm00120a002
613843 211358 31 None - 0 Human 4.0 pIC50 = 4.0 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 250 1 0 2 2.5 CN1C(=O)CN=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
CHEMBL73096 211358 31 None - 0 Human 4.0 pIC50 = 4.0 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 250 1 0 2 2.5 CN1C(=O)CN=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
14208248 211420 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 441 3 2 3 4.4 O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccc(C(F)(F)F)cc1 10.1021/jm00120a002
CHEMBL73561 211420 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 441 3 2 3 4.4 O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccc(C(F)(F)F)cc1 10.1021/jm00120a002
44381819 65389 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
Inhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptorInhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptor
ChEMBL 723 20 7 8 3.2 CCCC[C@H](N[C@@H](C#N)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(97)00107-8
CHEMBL168435 65389 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
Inhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptorInhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptor
ChEMBL 723 20 7 8 3.2 CCCC[C@H](N[C@@H](C#N)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(97)00107-8
44349164 25317 0 None - 0 Rat 4.0 pIC50 = 4.0 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 320 10 3 3 2.0 CCCCCNC(=O)C(CCC(=O)O)NC(=O)c1ccccc1 10.1021/jm00079a003
CHEMBL127551 25317 0 None - 0 Rat 4.0 pIC50 = 4.0 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 320 10 3 3 2.0 CCCCCNC(=O)C(CCC(=O)O)NC(=O)c1ccccc1 10.1021/jm00079a003
10742340 214448 0 None - 0 Mouse 7.0 pIC50 = 7.0 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 453 4 3 5 5.2 Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2ccc(Cl)c(Cl)c2)c1 10.1021/jm970373j
CHEMBL9535 214448 0 None - 0 Mouse 7.0 pIC50 = 7.0 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 453 4 3 5 5.2 Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2ccc(Cl)c(Cl)c2)c1 10.1021/jm970373j
90663975 113575 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 839 21 9 9 3.0 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1cccc(O)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL3144537 113575 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 839 21 9 9 3.0 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1cccc(O)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
15104607 170192 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 497 13 2 2 6.9 CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cccc2ccccc12 10.1021/jm00116a002
CHEMBL419585 170192 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 497 13 2 2 6.9 CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cccc2ccccc12 10.1021/jm00116a002
145987307 173880 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
Displacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting methodDisplacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting method
ChEMBL 431 5 4 6 3.4 O=C(O)c1cccc(NC(=S)NNc2nc3ccccc3c(=O)n2-c2ccccc2)c1 10.1039/C7MD00171A
CHEMBL4289939 173880 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
Displacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting methodDisplacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting method
ChEMBL 431 5 4 6 3.4 O=C(O)c1cccc(NC(=S)NNc2nc3ccccc3c(=O)n2-c2ccccc2)c1 10.1039/C7MD00171A
15177358 52940604 23302 0 None - 0 Mouse 6.0 pIC50 = 6.0 Binding
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 667 9 4 4 7.1 ClC(Cl)(Cl)Cl.O=C(NC(Cc1c[nH]c2ccccc12)NC(=O)C(CO)Cc1ccccc1)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
CHEMBL1237153 23302 0 None - 0 Mouse 6.0 pIC50 = 6.0 Binding
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 667 9 4 4 7.1 ClC(Cl)(Cl)Cl.O=C(NC(Cc1c[nH]c2ccccc12)NC(=O)C(CO)Cc1ccccc1)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
44386048 68291 0 None - 0 Mouse 7.0 pIC50 = 7 Binding
Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.
ChEMBL 541 9 4 4 5.3 O=C(O)C[C@@H](Cc1ccccc1)NC(=O)/C(=C/c1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1016/S0960-894X(00)80273-5
CHEMBL177081 68291 0 None - 0 Mouse 7.0 pIC50 = 7 Binding
Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.
ChEMBL 541 9 4 4 5.3 O=C(O)C[C@@H](Cc1ccccc1)NC(=O)/C(=C/c1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1016/S0960-894X(00)80273-5
136794946 113389 0 None - 0 Human 6.0 pIC50 = 6 Binding
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 857 21 9 10 3.2 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1[N+](=O)[O-])C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
15689731 113389 0 None - 0 Human 6.0 pIC50 = 6 Binding
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 857 21 9 10 3.2 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1[N+](=O)[O-])C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
CHEMBL3142903 113389 0 None - 0 Human 6.0 pIC50 = 6 Binding
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 857 21 9 10 3.2 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1[N+](=O)[O-])C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
14991541 113585 0 None - 0 Human 5.0 pIC50 = 5 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 843 22 8 8 3.3 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCc1ccc(F)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL3144546 113585 0 None - 0 Human 5.0 pIC50 = 5 Binding
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 843 22 8 8 3.3 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCc1ccc(F)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
44382456 127239 0 None 1 3 Human 10.0 pKd = 10.0 Binding
The equilibrium binding constant to guinea pig cerebral cortex membranes was measuredThe equilibrium binding constant to guinea pig cerebral cortex membranes was measured
ChEMBL 572 10 5 5 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccc(N)cc1 10.1016/0960-894X(95)00435-V
CHEMBL354049 127239 0 None 1 3 Human 10.0 pKd = 10.0 Binding
The equilibrium binding constant to guinea pig cerebral cortex membranes was measuredThe equilibrium binding constant to guinea pig cerebral cortex membranes was measured
ChEMBL 572 10 5 5 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccc(N)cc1 10.1016/0960-894X(95)00435-V
CHEMBL83942 127239 0 None 1 3 Human 10.0 pKd = 10.0 Binding
The equilibrium binding constant to guinea pig cerebral cortex membranes was measuredThe equilibrium binding constant to guinea pig cerebral cortex membranes was measured
ChEMBL 572 10 5 5 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccc(N)cc1 10.1016/0960-894X(95)00435-V
44318341 212778 0 None 1 3 Human 9.6 pKd = 9.6 Binding
The equilibrium binding constant to guinea pig cerebral cortex membranes was measuredThe equilibrium binding constant to guinea pig cerebral cortex membranes was measured
ChEMBL 698 10 5 5 5.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccc(N)c(I)c1 10.1016/0960-894X(95)00435-V
CHEMBL1628582 212778 0 None 1 3 Human 9.6 pKd = 9.6 Binding
The equilibrium binding constant to guinea pig cerebral cortex membranes was measuredThe equilibrium binding constant to guinea pig cerebral cortex membranes was measured
ChEMBL 698 10 5 5 5.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccc(N)c(I)c1 10.1016/0960-894X(95)00435-V
CHEMBL84864 212778 0 None 1 3 Human 9.6 pKd = 9.6 Binding
The equilibrium binding constant to guinea pig cerebral cortex membranes was measuredThe equilibrium binding constant to guinea pig cerebral cortex membranes was measured
ChEMBL 698 10 5 5 5.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccc(N)c(I)c1 10.1016/0960-894X(95)00435-V
CHEMBL413654 219858 0 None 2 2 Rat 8.9 pKd = 8.9 Binding
Tested in vitro by the gastrin binding assay for the competitive binding with iodinated gastrin for the gastrin receptors in AR42J cellsTested in vitro by the gastrin binding assay for the competitive binding with iodinated gastrin for the gastrin receptors in AR42J cells
ChEMBL None None None CSCC[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@H](CC(=O)O)C(=O)N[C@H](Cc1ccccc1)C(N)=O 10.1021/jm00048a016
10075052 196453 0 None -10 2 Human 8.5 pKd = 8.5 Binding
Binding affinity to human CCK2 receptor expressed in CHO cell membrane by saturation binding assayBinding affinity to human CCK2 receptor expressed in CHO cell membrane by saturation binding assay
ChEMBL 510 3 2 3 4.3 CN1C(=O)[C@H](NC(=O)Nc2cccc(I)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm801439x
CHEMBL515268 196453 0 None -10 2 Human 8.5 pKd = 8.5 Binding
Binding affinity to human CCK2 receptor expressed in CHO cell membrane by saturation binding assayBinding affinity to human CCK2 receptor expressed in CHO cell membrane by saturation binding assay
ChEMBL 510 3 2 3 4.3 CN1C(=O)[C@H](NC(=O)Nc2cccc(I)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm801439x
CHEMBL515288 196453 0 None -10 2 Human 8.5 pKd = 8.5 Binding
Binding affinity to human CCK2 receptor expressed in CHO cell membrane by saturation binding assayBinding affinity to human CCK2 receptor expressed in CHO cell membrane by saturation binding assay
ChEMBL 510 3 2 3 4.3 CN1C(=O)[C@H](NC(=O)Nc2cccc(I)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm801439x
CHEMBL120632 215384 33 None 5 3 Human 7.7 pKd = 7.7 Binding
Binding affinity to CCKB receptor (unknown origin) expressed in HEK cells after 4 hrs by RP-LC-ICPMS analysisBinding affinity to CCKB receptor (unknown origin) expressed in HEK cells after 4 hrs by RP-LC-ICPMS analysis
ChEMBL None None None CSCC[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01320
145978895 173244 0 None - 1 Human 7.5 pKd = 7.5 Binding
Binding affinity to CCKB receptor (unknown origin) expressed in HEK cells after 4 hrs by RP-LC-ICPMS analysisBinding affinity to CCKB receptor (unknown origin) expressed in HEK cells after 4 hrs by RP-LC-ICPMS analysis
ChEMBL 1063 32 12 10 0.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCCNC(=O)[C@H](CCCNC(=N)N)NC(=O)C[Se]c1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01320
CHEMBL4278080 173244 0 None - 1 Human 7.5 pKd = 7.5 Binding
Binding affinity to CCKB receptor (unknown origin) expressed in HEK cells after 4 hrs by RP-LC-ICPMS analysisBinding affinity to CCKB receptor (unknown origin) expressed in HEK cells after 4 hrs by RP-LC-ICPMS analysis
ChEMBL 1063 32 12 10 0.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCCNC(=O)[C@H](CCCNC(=N)N)NC(=O)C[Se]c1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01320
CHEMBL413654 219858 0 None -2 2 Human 8.5 pKd = 8.5 Binding
Tested in vitro for gastrin binding to gastrin receptors from guinea pig gastric glandsTested in vitro for gastrin binding to gastrin receptors from guinea pig gastric glands
ChEMBL None None None CSCC[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@H](CC(=O)O)C(=O)N[C@H](Cc1ccccc1)C(N)=O 10.1021/jm00048a016
145991328 173686 0 None - 1 Human 7.3 pKd = 7.3 Binding
Binding affinity to CCKB receptor (unknown origin) expressed in HEK cells after 4 hrs by RP-LC-ICPMS analysisBinding affinity to CCKB receptor (unknown origin) expressed in HEK cells after 4 hrs by RP-LC-ICPMS analysis
ChEMBL 1086 34 13 11 0.1 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCCNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC[Se]C)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01320
CHEMBL4286411 173686 0 None - 1 Human 7.3 pKd = 7.3 Binding
Binding affinity to CCKB receptor (unknown origin) expressed in HEK cells after 4 hrs by RP-LC-ICPMS analysisBinding affinity to CCKB receptor (unknown origin) expressed in HEK cells after 4 hrs by RP-LC-ICPMS analysis
ChEMBL 1086 34 13 11 0.1 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCCNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC[Se]C)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01320
44461961 112386 0 None -9 3 Human 8.1 pKd = 8.1 Binding
The equilibrium binding constant to pig cerebral cortex membranes was measuredThe equilibrium binding constant to pig cerebral cortex membranes was measured
ChEMBL 724 11 4 5 6.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccc(N=[N+]=[N-])c(I)c1 10.1016/0960-894X(95)00435-V
CHEMBL2079605 112386 0 None -9 3 Human 8.1 pKd = 8.1 Binding
The equilibrium binding constant to pig cerebral cortex membranes was measuredThe equilibrium binding constant to pig cerebral cortex membranes was measured
ChEMBL 724 11 4 5 6.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccc(N=[N+]=[N-])c(I)c1 10.1016/0960-894X(95)00435-V
CHEMBL312252 112386 0 None -9 3 Human 8.1 pKd = 8.1 Binding
The equilibrium binding constant to pig cerebral cortex membranes was measuredThe equilibrium binding constant to pig cerebral cortex membranes was measured
ChEMBL 724 11 4 5 6.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccc(N=[N+]=[N-])c(I)c1 10.1016/0960-894X(95)00435-V
25193919 195837 0 None - 1 Human 10.7 pKi = 10.7 Binding
Displacement of [125I]CCK-26-33 from CCK2R-MOPR coexpressed in CHO cellsDisplacement of [125I]CCK-26-33 from CCK2R-MOPR coexpressed in CHO cells
ChEMBL 786 22 6 10 1.7 CNC(=O)COCC(=O)NCCCCCCNC(=O)COCC(=O)NCCOc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm800174p
CHEMBL509524 195837 0 None - 1 Human 10.7 pKi = 10.7 Binding
Displacement of [125I]CCK-26-33 from CCK2R-MOPR coexpressed in CHO cellsDisplacement of [125I]CCK-26-33 from CCK2R-MOPR coexpressed in CHO cells
ChEMBL 786 22 6 10 1.7 CNC(=O)COCC(=O)NCCCCCCNC(=O)COCC(=O)NCCOc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm800174p
44580932 180249 0 None -1 2 Human 10.4 pKi = 10.4 Binding
Displacement of [3H]DAMGO from CCK2R-MOPR coexpressed in CHO cellsDisplacement of [3H]DAMGO from CCK2R-MOPR coexpressed in CHO cells
ChEMBL 617 14 6 10 -1.5 CNC(=O)COCC(=O)NCCCCNC(=O)COCC(=O)N[C@H]1CC[C@@]2(O)[C@H]3Cc4cc(O)cc5c4[C@@]2(CCN3C)[C@H]1O5 10.1021/jm800174p
CHEMBL452991 180249 0 None -1 2 Human 10.4 pKi = 10.4 Binding
Displacement of [3H]DAMGO from CCK2R-MOPR coexpressed in CHO cellsDisplacement of [3H]DAMGO from CCK2R-MOPR coexpressed in CHO cells
ChEMBL 617 14 6 10 -1.5 CNC(=O)COCC(=O)NCCCCNC(=O)COCC(=O)N[C@H]1CC[C@@]2(O)[C@H]3Cc4cc(O)cc5c4[C@@]2(CCN3C)[C@H]1O5 10.1021/jm800174p
25193919 195837 0 None - 1 Human 10.3 pKi = 10.3 Binding
Displacement of [125I]CCK-26-33 from CCK2 receptor expressed in CHO cellsDisplacement of [125I]CCK-26-33 from CCK2 receptor expressed in CHO cells
ChEMBL 786 22 6 10 1.7 CNC(=O)COCC(=O)NCCCCCCNC(=O)COCC(=O)NCCOc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm800174p
CHEMBL509524 195837 0 None - 1 Human 10.3 pKi = 10.3 Binding
Displacement of [125I]CCK-26-33 from CCK2 receptor expressed in CHO cellsDisplacement of [125I]CCK-26-33 from CCK2 receptor expressed in CHO cells
ChEMBL 786 22 6 10 1.7 CNC(=O)COCC(=O)NCCCCCCNC(=O)COCC(=O)NCCOc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm800174p
CHEMBL1206334 215385 0 None 1023 2 Human 10.2 pKi = 10.2 Binding
Tested for the inhibition of [3H]pCCK-8 to Cholecystokinin type B receptor in guinea pig brainTested for the inhibition of [3H]pCCK-8 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL None None None CCCC[C@H](NC(=O)[C@@H](N)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80678-2
CHEMBL262894 215385 0 None 1023 2 Human 10.2 pKi = 10.2 Binding
Tested for the inhibition of [3H]pCCK-8 to Cholecystokinin type B receptor in guinea pig brainTested for the inhibition of [3H]pCCK-8 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL None None None CCCC[C@H](NC(=O)[C@@H](N)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80678-2
887 10882 33 None -1 4 Human 10.1 pKi = 10.1 Binding
Binding affinity at human CCK2 receptorBinding affinity at human CCK2 receptor
ChEMBL 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 10.1016/j.bmc.2007.12.047
9870520 10882 33 None -1 4 Human 10.1 pKi = 10.1 Binding
Binding affinity at human CCK2 receptorBinding affinity at human CCK2 receptor
ChEMBL 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 10.1016/j.bmc.2007.12.047
CHEMBL324547 10882 33 None -1 4 Human 10.1 pKi = 10.1 Binding
Binding affinity at human CCK2 receptorBinding affinity at human CCK2 receptor
ChEMBL 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 10.1016/j.bmc.2007.12.047
DB12355 10882 33 None -1 4 Human 10.1 pKi = 10.1 Binding
Binding affinity at human CCK2 receptorBinding affinity at human CCK2 receptor
ChEMBL 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 10.1016/j.bmc.2007.12.047
135423404 92287 0 None 16 4 Human 10.0 pKi = 10.0 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 570 8 2 7 5.0 O=C(CN1N=C(C2CCCCC2)c2ccccc2N(CC(=O)C2CCCC2)C1=O)Nc1cccc(-c2noc(=O)[nH]2)c1 10.1021/jm070139l
CHEMBL227276 92287 0 None 16 4 Human 10.0 pKi = 10.0 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 570 8 2 7 5.0 O=C(CN1N=C(C2CCCCC2)c2ccccc2N(CC(=O)C2CCCC2)C1=O)Nc1cccc(-c2noc(=O)[nH]2)c1 10.1021/jm070139l
CHEMBL2372781 217067 0 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL None None None CCCC[C@H](NC(=O)CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCC)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(S(=O)(=O)O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)O 10.1021/jm00053a022
887 10882 33 None -1 4 Human 9.9 pKi = 9.9 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 10.1021/jm051219x
9870520 10882 33 None -1 4 Human 9.9 pKi = 9.9 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 10.1021/jm051219x
CHEMBL324547 10882 33 None -1 4 Human 9.9 pKi = 9.9 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 10.1021/jm051219x
DB12355 10882 33 None -1 4 Human 9.9 pKi = 9.9 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 10.1021/jm051219x
887 10882 33 None -1 4 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 10.1021/jm070139l
9870520 10882 33 None -1 4 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 10.1021/jm070139l
CHEMBL324547 10882 33 None -1 4 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 10.1021/jm070139l
DB12355 10882 33 None -1 4 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 10.1021/jm070139l
903 9798 9 None - 1 Mouse 9.8 pKi = 9.8 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1021/jm00087a011
9850711 9798 9 None - 1 Mouse 9.8 pKi = 9.8 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1021/jm00087a011
CHEMBL138534 9798 9 None - 1 Mouse 9.8 pKi = 9.8 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1021/jm00087a011
CHEMBL2111312 9798 9 None - 1 Mouse 9.8 pKi = 9.8 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1021/jm00087a011
CHEMBL411271 219654 0 None 2 3 Human 9.8 pKi = 9.8 Binding
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm0000416
CHEMBL384035 219095 4 None 8 4 Human 9.8 pKi = 9.8 Binding
Tested for the inhibition of [3H]pCCK-8 binding to Cholecystokinin type B receptor in guinea pig brainTested for the inhibition of [3H]pCCK-8 binding to Cholecystokinin type B receptor in guinea pig brain
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80678-2
CHEMBL428666 219095 4 None 8 4 Human 9.8 pKi = 9.8 Binding
Tested for the inhibition of [3H]pCCK-8 binding to Cholecystokinin type B receptor in guinea pig brainTested for the inhibition of [3H]pCCK-8 binding to Cholecystokinin type B receptor in guinea pig brain
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80678-2
44346225 168688 0 None 12022 2 Human 9.8 pKi = 9.8 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 564 6 3 4 5.6 O=C(Nc1cccc(CO)c1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
CHEMBL415240 168688 0 None 12022 2 Human 9.8 pKi = 9.8 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 564 6 3 4 5.6 O=C(Nc1cccc(CO)c1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
135610887 92217 0 None 22 4 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 558 7 2 7 4.8 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nc(=O)o[nH]3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL226583 92217 0 None 22 4 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 558 7 2 7 4.8 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nc(=O)o[nH]3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
44382456 127239 0 None -1 3 Mouse 9.7 pKi = 9.7 Binding
The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in mouse cortex.The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in mouse cortex.
ChEMBL 572 10 5 5 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccc(N)cc1 10.1016/S0960-894X(00)80686-1
CHEMBL354049 127239 0 None -1 3 Mouse 9.7 pKi = 9.7 Binding
The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in mouse cortex.The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in mouse cortex.
ChEMBL 572 10 5 5 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccc(N)cc1 10.1016/S0960-894X(00)80686-1
CHEMBL83942 127239 0 None -1 3 Mouse 9.7 pKi = 9.7 Binding
The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in mouse cortex.The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in mouse cortex.
ChEMBL 572 10 5 5 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccc(N)cc1 10.1016/S0960-894X(00)80686-1
9958214 121571 0 None 269 2 Human 9.7 pKi = 9.7 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 517 7 2 4 5.1 CC(C)CCN1C(=O)C(NC(=O)Nc2cccc(N(C)C)c2)C(=O)N(c2ccccc2F)c2ccccc21 10.1021/jm990967h
CHEMBL333979 121571 0 None 269 2 Human 9.7 pKi = 9.7 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 517 7 2 4 5.1 CC(C)CCN1C(=O)C(NC(=O)Nc2cccc(N(C)C)c2)C(=O)N(c2ccccc2F)c2ccccc21 10.1021/jm990967h
CHEMBL382409 219085 0 None 6918 2 Human 9.7 pKi = 9.7 Binding
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
44346047 120179 0 None 537 2 Human 9.7 pKi = 9.7 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 568 7 2 7 6.4 O=C(Nc1cccc(C2N=NN=N2)c1)NC1C(=O)N(CCC2CCCC2)c2ccccc2N(c2ccccc2F)C1=O 10.1021/jm990967h
CHEMBL331872 120179 0 None 537 2 Human 9.7 pKi = 9.7 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 568 7 2 7 6.4 O=C(Nc1cccc(C2N=NN=N2)c1)NC1C(=O)N(CCC2CCCC2)c2ccccc2N(c2ccccc2F)C1=O 10.1021/jm990967h
CHEMBL384035 219095 4 None 8 4 Human 9.6 pKi = 9.6 Binding
Displacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranesDisplacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranes
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00126a007
CHEMBL428666 219095 4 None 8 4 Human 9.6 pKi = 9.6 Binding
Displacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranesDisplacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranes
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00126a007
16732162 148871 0 None 1862 2 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 584 8 2 6 6.4 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3ccc(C(=O)O)o3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL388144 148871 0 None 1862 2 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 584 8 2 6 6.4 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3ccc(C(=O)O)o3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
9958214 121571 0 None 269 2 Human 9.6 pKi = 9.6 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 517 7 2 4 5.1 CC(C)CCN1C(=O)C(NC(=O)Nc2cccc(N(C)C)c2)C(=O)N(c2ccccc2F)c2ccccc21 10.1021/jm990967h
CHEMBL333979 121571 0 None 269 2 Human 9.6 pKi = 9.6 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 517 7 2 4 5.1 CC(C)CCN1C(=O)C(NC(=O)Nc2cccc(N(C)C)c2)C(=O)N(c2ccccc2F)c2ccccc21 10.1021/jm990967h
5311400 10066 1 None 2 3 Human 9.6 pKi = 9.6 Binding
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL None None None None 10.1021/jm0000416
900 10066 1 None 2 3 Human 9.6 pKi = 9.6 Binding
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL None None None None 10.1021/jm0000416
CHEMBL262197 10066 1 None 2 3 Human 9.6 pKi = 9.6 Binding
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL None None None None 10.1021/jm0000416
4627 7609 50 None -1 5 Human 9.6 pKi = 9.6 Binding
Displacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranesDisplacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranes
ChEMBL None None None None 10.1021/jm00126a007
864 7609 50 None -1 5 Human 9.6 pKi = 9.6 Binding
Displacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranesDisplacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranes
ChEMBL None None None None 10.1021/jm00126a007
9833444 7609 50 None -1 5 Human 9.6 pKi = 9.6 Binding
Displacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranesDisplacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranes
ChEMBL None None None None 10.1021/jm00126a007
CHEMBL1121 7609 50 None -1 5 Human 9.6 pKi = 9.6 Binding
Displacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranesDisplacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranes
ChEMBL None None None None 10.1021/jm00126a007
DB09142 7609 50 None -1 5 Human 9.6 pKi = 9.6 Binding
Displacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranesDisplacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranes
ChEMBL None None None None 10.1021/jm00126a007
4627 7609 50 None -1 5 Human 9.6 pKi = 9.6 Binding
Tested for the inhibition of [3H]pCCK-8 binding to Cholecystokinin type B receptor in guinea pig brainTested for the inhibition of [3H]pCCK-8 binding to Cholecystokinin type B receptor in guinea pig brain
ChEMBL None None None None 10.1016/S0960-894X(00)80678-2
864 7609 50 None -1 5 Human 9.6 pKi = 9.6 Binding
Tested for the inhibition of [3H]pCCK-8 binding to Cholecystokinin type B receptor in guinea pig brainTested for the inhibition of [3H]pCCK-8 binding to Cholecystokinin type B receptor in guinea pig brain
ChEMBL None None None None 10.1016/S0960-894X(00)80678-2
9833444 7609 50 None -1 5 Human 9.6 pKi = 9.6 Binding
Tested for the inhibition of [3H]pCCK-8 binding to Cholecystokinin type B receptor in guinea pig brainTested for the inhibition of [3H]pCCK-8 binding to Cholecystokinin type B receptor in guinea pig brain
ChEMBL None None None None 10.1016/S0960-894X(00)80678-2
CHEMBL1121 7609 50 None -1 5 Human 9.6 pKi = 9.6 Binding
Tested for the inhibition of [3H]pCCK-8 binding to Cholecystokinin type B receptor in guinea pig brainTested for the inhibition of [3H]pCCK-8 binding to Cholecystokinin type B receptor in guinea pig brain
ChEMBL None None None None 10.1016/S0960-894X(00)80678-2
DB09142 7609 50 None -1 5 Human 9.6 pKi = 9.6 Binding
Tested for the inhibition of [3H]pCCK-8 binding to Cholecystokinin type B receptor in guinea pig brainTested for the inhibition of [3H]pCCK-8 binding to Cholecystokinin type B receptor in guinea pig brain
ChEMBL None None None None 10.1016/S0960-894X(00)80678-2
16732163 148842 0 None 2 3 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 544 9 2 5 5.2 O=C(O)Cc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1021/jm070139l
CHEMBL387948 148842 0 None 2 3 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 544 9 2 5 5.2 O=C(O)Cc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1021/jm070139l
44345980 120911 0 None 79 2 Human 9.5 pKi = 9.5 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 538 6 2 7 6.2 CC(C)(C)CCN1C(=O)C(NC(=O)Nc2cccc(C3N=NN=N3)c2)C(=O)N(c2ccccc2)c2ccccc21 10.1021/jm990967h
CHEMBL332902 120911 0 None 79 2 Human 9.5 pKi = 9.5 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 538 6 2 7 6.2 CC(C)(C)CCN1C(=O)C(NC(=O)Nc2cccc(C3N=NN=N3)c2)C(=O)N(c2ccccc2)c2ccccc21 10.1021/jm990967h
16732164 150081 0 None 2 4 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 571 8 2 6 5.5 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2ccc3ccn(CC(=O)O)c3c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL389711 150081 0 None 2 4 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 571 8 2 6 5.5 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2ccc3ccn(CC(=O)O)c3c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
10769001 119958 0 None 13803 2 Human 9.5 pKi = 9.5 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 549 5 3 4 5.7 Nc1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 10.1021/jm990967h
CHEMBL331468 119958 0 None 13803 2 Human 9.5 pKi = 9.5 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 549 5 3 4 5.7 Nc1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 10.1021/jm990967h
4627 7609 50 None -1 5 Human 9.5 pKi = 9.5 Binding
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL None None None None 10.1021/jm0000416
864 7609 50 None -1 5 Human 9.5 pKi = 9.5 Binding
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL None None None None 10.1021/jm0000416
9833444 7609 50 None -1 5 Human 9.5 pKi = 9.5 Binding
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL None None None None 10.1021/jm0000416
CHEMBL1121 7609 50 None -1 5 Human 9.5 pKi = 9.5 Binding
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL None None None None 10.1021/jm0000416
DB09142 7609 50 None -1 5 Human 9.5 pKi = 9.5 Binding
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL None None None None 10.1021/jm0000416
4627 7609 50 None -1 5 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL None None None None 10.1021/jm00053a022
864 7609 50 None -1 5 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL None None None None 10.1021/jm00053a022
9833444 7609 50 None -1 5 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL None None None None 10.1021/jm00053a022
CHEMBL1121 7609 50 None -1 5 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL None None None None 10.1021/jm00053a022
DB09142 7609 50 None -1 5 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL None None None None 10.1021/jm00053a022
4627 7609 50 None -1 5 Human 9.5 pKi = 9.5 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL None None None None 10.1016/S0960-894X(00)80669-1
864 7609 50 None -1 5 Human 9.5 pKi = 9.5 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL None None None None 10.1016/S0960-894X(00)80669-1
9833444 7609 50 None -1 5 Human 9.5 pKi = 9.5 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL None None None None 10.1016/S0960-894X(00)80669-1
CHEMBL1121 7609 50 None -1 5 Human 9.5 pKi = 9.5 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL None None None None 10.1016/S0960-894X(00)80669-1
DB09142 7609 50 None -1 5 Human 9.5 pKi = 9.5 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL None None None None 10.1016/S0960-894X(00)80669-1
10505959 120268 0 None 74 2 Human 9.5 pKi = 9.5 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 513 6 2 4 5.4 CN(C)c1cccc(NC(=O)NC2C(=O)N(CCC(C)(C)C)c3ccccc3N(c3ccccc3)C2=O)c1 10.1021/jm990967h
CHEMBL331975 120268 0 None 74 2 Human 9.5 pKi = 9.5 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 513 6 2 4 5.4 CN(C)c1cccc(NC(=O)NC2C(=O)N(CCC(C)(C)C)c3ccccc3N(c3ccccc3)C2=O)c1 10.1021/jm990967h
CHEMBL411271 219654 0 None -2 3 Rat 9.5 pKi = 9.5 Binding
Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm0000416
16733469 92293 0 None 4 4 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 576 10 2 6 5.8 O=C(O)CSc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1021/jm070139l
CHEMBL227333 92293 0 None 4 4 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 576 10 2 6 5.8 O=C(O)CSc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1021/jm070139l
10815832 21954 0 None 109 2 Human 9.5 pKi = 9.5 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 520 7 2 4 5.8 CSc1cccc(NC(=O)NC2C(=O)N(CCC(C)C)c3ccccc3N(c3ccccc3F)C2=O)c1 10.1021/jm990967h
CHEMBL121021 21954 0 None 109 2 Human 9.5 pKi = 9.5 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 520 7 2 4 5.8 CSc1cccc(NC(=O)NC2C(=O)N(CCC(C)C)c3ccccc3N(c3ccccc3F)C2=O)c1 10.1021/jm990967h
16733466 92292 0 None 3 4 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 558 10 2 5 5.6 O=C(O)CCc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1021/jm070139l
CHEMBL227330 92292 0 None 3 4 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 558 10 2 5 5.6 O=C(O)CCc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1021/jm070139l
108187 7713 37 None -4 5 Human 9.5 pKi = 9.5 Binding
Inhibition by displacing [3H]CCK-8S against human Cholecystokinin type B receptorInhibition by displacing [3H]CCK-8S against human Cholecystokinin type B receptor
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm990967h
873 7713 37 None -4 5 Human 9.5 pKi = 9.5 Binding
Inhibition by displacing [3H]CCK-8S against human Cholecystokinin type B receptorInhibition by displacing [3H]CCK-8S against human Cholecystokinin type B receptor
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm990967h
CHEMBL2062154 7713 37 None -4 5 Human 9.5 pKi = 9.5 Binding
Inhibition by displacing [3H]CCK-8S against human Cholecystokinin type B receptorInhibition by displacing [3H]CCK-8S against human Cholecystokinin type B receptor
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm990967h
CHEMBL287735 7713 37 None -4 5 Human 9.5 pKi = 9.5 Binding
Inhibition by displacing [3H]CCK-8S against human Cholecystokinin type B receptorInhibition by displacing [3H]CCK-8S against human Cholecystokinin type B receptor
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm990967h
16733307 175601 0 None 1819 2 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 585 8 2 7 5.8 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nc(C(=O)O)co3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL437736 175601 0 None 1819 2 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 585 8 2 7 5.8 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nc(C(=O)O)co3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
4627 7609 50 None -1 5 Human 9.4 pKi = 9.4 Binding
Displacement of radiolabeled CCK-8s from human CCK2 receptorDisplacement of radiolabeled CCK-8s from human CCK2 receptor
ChEMBL None None None None 10.1021/jm8007618
864 7609 50 None -1 5 Human 9.4 pKi = 9.4 Binding
Displacement of radiolabeled CCK-8s from human CCK2 receptorDisplacement of radiolabeled CCK-8s from human CCK2 receptor
ChEMBL None None None None 10.1021/jm8007618
9833444 7609 50 None -1 5 Human 9.4 pKi = 9.4 Binding
Displacement of radiolabeled CCK-8s from human CCK2 receptorDisplacement of radiolabeled CCK-8s from human CCK2 receptor
ChEMBL None None None None 10.1021/jm8007618
CHEMBL1121 7609 50 None -1 5 Human 9.4 pKi = 9.4 Binding
Displacement of radiolabeled CCK-8s from human CCK2 receptorDisplacement of radiolabeled CCK-8s from human CCK2 receptor
ChEMBL None None None None 10.1021/jm8007618
DB09142 7609 50 None -1 5 Human 9.4 pKi = 9.4 Binding
Displacement of radiolabeled CCK-8s from human CCK2 receptorDisplacement of radiolabeled CCK-8s from human CCK2 receptor
ChEMBL None None None None 10.1021/jm8007618
9850043 119650 2 None 1 3 Human 9.4 pKi = 9.4 Binding
Inhibition by displacing [3H]CCK-8S against human Cholecystokinin type B receptorInhibition by displacing [3H]CCK-8S against human Cholecystokinin type B receptor
ChEMBL 534 5 2 3 6.1 O=C(Nc1ccccc1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
CHEMBL330977 119650 2 None 1 3 Human 9.4 pKi = 9.4 Binding
Inhibition by displacing [3H]CCK-8S against human Cholecystokinin type B receptorInhibition by displacing [3H]CCK-8S against human Cholecystokinin type B receptor
ChEMBL 534 5 2 3 6.1 O=C(Nc1ccccc1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
44328894 115401 0 None 25 2 Human 9.4 pKi = 9.4 Binding
Tested for its selectivity against human Cholecystokinin type B receptor isolated from a human temporal cortex cDNA library and stably transfected into a HeLa cell line. (n=1)Tested for its selectivity against human Cholecystokinin type B receptor isolated from a human temporal cortex cDNA library and stably transfected into a HeLa cell line. (n=1)
ChEMBL 587 5 2 4 4.8 O=C(Nc1ccc(F)cc1)NC1C(=O)N(CC(=O)N2CC3CCC(CC3)C2)c2ccccc2N(c2ccccc2F)C1=O 10.1016/S0960-894X(96)00613-0
CHEMBL320624 115401 0 None 25 2 Human 9.4 pKi = 9.4 Binding
Tested for its selectivity against human Cholecystokinin type B receptor isolated from a human temporal cortex cDNA library and stably transfected into a HeLa cell line. (n=1)Tested for its selectivity against human Cholecystokinin type B receptor isolated from a human temporal cortex cDNA library and stably transfected into a HeLa cell line. (n=1)
ChEMBL 587 5 2 4 4.8 O=C(Nc1ccc(F)cc1)NC1C(=O)N(CC(=O)N2CC3CCC(CC3)C2)c2ccccc2N(c2ccccc2F)C1=O 10.1016/S0960-894X(96)00613-0
108187 7713 37 None -4 5 Human 9.4 pKi = 9.4 Binding
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm970439a
873 7713 37 None -4 5 Human 9.4 pKi = 9.4 Binding
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm970439a
CHEMBL2062154 7713 37 None -4 5 Human 9.4 pKi = 9.4 Binding
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm970439a
CHEMBL287735 7713 37 None -4 5 Human 9.4 pKi = 9.4 Binding
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm970439a
44318341 212778 0 None 1 3 Human 9.4 pKi = 9.4 Binding
Inhibition of binding of [125I]-PD 142308 to CCK-B receptor was determinedInhibition of binding of [125I]-PD 142308 to CCK-B receptor was determined
ChEMBL 698 10 5 5 5.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccc(N)c(I)c1 10.1016/0960-894X(95)00435-V
CHEMBL1628582 212778 0 None 1 3 Human 9.4 pKi = 9.4 Binding
Inhibition of binding of [125I]-PD 142308 to CCK-B receptor was determinedInhibition of binding of [125I]-PD 142308 to CCK-B receptor was determined
ChEMBL 698 10 5 5 5.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccc(N)c(I)c1 10.1016/0960-894X(95)00435-V
CHEMBL84864 212778 0 None 1 3 Human 9.4 pKi = 9.4 Binding
Inhibition of binding of [125I]-PD 142308 to CCK-B receptor was determinedInhibition of binding of [125I]-PD 142308 to CCK-B receptor was determined
ChEMBL 698 10 5 5 5.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccc(N)c(I)c1 10.1016/0960-894X(95)00435-V
4627 7609 50 None 1 5 Rat 9.4 pKi = 9.4 Binding
Binding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomesBinding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomes
ChEMBL None None None None 10.1021/jm970477u
864 7609 50 None 1 5 Rat 9.4 pKi = 9.4 Binding
Binding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomesBinding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomes
ChEMBL None None None None 10.1021/jm970477u
9833444 7609 50 None 1 5 Rat 9.4 pKi = 9.4 Binding
Binding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomesBinding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomes
ChEMBL None None None None 10.1021/jm970477u
CHEMBL1121 7609 50 None 1 5 Rat 9.4 pKi = 9.4 Binding
Binding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomesBinding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomes
ChEMBL None None None None 10.1021/jm970477u
DB09142 7609 50 None 1 5 Rat 9.4 pKi = 9.4 Binding
Binding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomesBinding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomes
ChEMBL None None None None 10.1021/jm970477u
4627 7609 50 None 1 5 Rat 9.4 pKi = 9.4 Binding
Binding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligand
ChEMBL None None None None 10.1021/jm990252e
864 7609 50 None 1 5 Rat 9.4 pKi = 9.4 Binding
Binding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligand
ChEMBL None None None None 10.1021/jm990252e
9833444 7609 50 None 1 5 Rat 9.4 pKi = 9.4 Binding
Binding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligand
ChEMBL None None None None 10.1021/jm990252e
CHEMBL1121 7609 50 None 1 5 Rat 9.4 pKi = 9.4 Binding
Binding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligand
ChEMBL None None None None 10.1021/jm990252e
DB09142 7609 50 None 1 5 Rat 9.4 pKi = 9.4 Binding
Binding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligand
ChEMBL None None None None 10.1021/jm990252e
135529065 163794 0 None 7 3 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 588 7 2 7 5.2 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nc(=O)o[nH]3)c2)C(=O)N(C2CCCCCC2)c2ccccc21 10.1016/j.bmc.2007.12.047
CHEMBL407340 163794 0 None 7 3 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 588 7 2 7 5.2 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nc(=O)o[nH]3)c2)C(=O)N(C2CCCCCC2)c2ccccc21 10.1016/j.bmc.2007.12.047
CHEMBL1207511 215388 0 None 2398 2 Human 9.3 pKi = 9.3 Binding
Tested for the inhibition of [3H]pCCK-8 to Cholecystokinin type B receptor in guinea pig brainTested for the inhibition of [3H]pCCK-8 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80678-2
CHEMBL412917 215388 0 None 2398 2 Human 9.3 pKi = 9.3 Binding
Tested for the inhibition of [3H]pCCK-8 to Cholecystokinin type B receptor in guinea pig brainTested for the inhibition of [3H]pCCK-8 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80678-2
10768190 119608 0 None 15 2 Human 9.3 pKi = 9.3 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 516 6 2 4 6.0 CSc1cccc(NC(=O)NC2C(=O)N(CCC(C)(C)C)c3ccccc3N(c3ccccc3)C2=O)c1 10.1021/jm990967h
CHEMBL330773 119608 0 None 15 2 Human 9.3 pKi = 9.3 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 516 6 2 4 6.0 CSc1cccc(NC(=O)NC2C(=O)N(CCC(C)(C)C)c3ccccc3N(c3ccccc3)C2=O)c1 10.1021/jm990967h
44351446 162920 0 None 3 2 Human 9.3 pKi = 9.3 Binding
Binding affinity (affinity state 1) for Cholecystokinin type B receptor, was determined using CHO cellsBinding affinity (affinity state 1) for Cholecystokinin type B receptor, was determined using CHO cells
ChEMBL 631 9 3 8 4.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc([N+](=O)[O-])cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL406359 162920 0 None 3 2 Human 9.3 pKi = 9.3 Binding
Binding affinity (affinity state 1) for Cholecystokinin type B receptor, was determined using CHO cellsBinding affinity (affinity state 1) for Cholecystokinin type B receptor, was determined using CHO cells
ChEMBL 631 9 3 8 4.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc([N+](=O)[O-])cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
6439414 9799 14 None 2454 2 Mouse 9.3 pKi = 9.3 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 612 11 5 5 4.6 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)/C=C/C(=O)O 10.1021/jm00087a011
867 9799 14 None 2454 2 Mouse 9.3 pKi = 9.3 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 612 11 5 5 4.6 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)/C=C/C(=O)O 10.1021/jm00087a011
CHEMBL3351022 9799 14 None 2454 2 Mouse 9.3 pKi = 9.3 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 612 11 5 5 4.6 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)/C=C/C(=O)O 10.1021/jm00087a011
CHEMBL341460 9799 14 None 2454 2 Mouse 9.3 pKi = 9.3 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 612 11 5 5 4.6 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)/C=C/C(=O)O 10.1021/jm00087a011
44318341 212778 0 None -1 3 Mouse 9.3 pKi = 9.3 Binding
Binding affinity towards CCK-B receptor in mouse cerebral cortex membrane using [125I]bolton assayBinding affinity towards CCK-B receptor in mouse cerebral cortex membrane using [125I]bolton assay
ChEMBL 698 10 5 5 5.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccc(N)c(I)c1 10.1016/0960-894X(95)00435-V
CHEMBL1628582 212778 0 None -1 3 Mouse 9.3 pKi = 9.3 Binding
Binding affinity towards CCK-B receptor in mouse cerebral cortex membrane using [125I]bolton assayBinding affinity towards CCK-B receptor in mouse cerebral cortex membrane using [125I]bolton assay
ChEMBL 698 10 5 5 5.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccc(N)c(I)c1 10.1016/0960-894X(95)00435-V
CHEMBL84864 212778 0 None -1 3 Mouse 9.3 pKi = 9.3 Binding
Binding affinity towards CCK-B receptor in mouse cerebral cortex membrane using [125I]bolton assayBinding affinity towards CCK-B receptor in mouse cerebral cortex membrane using [125I]bolton assay
ChEMBL 698 10 5 5 5.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccc(N)c(I)c1 10.1016/0960-894X(95)00435-V
10509035 21281 0 None - 1 Human 9.3 pKi = 9.3 Binding
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 714 19 7 8 0.3 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CS(=O)(=O)O 10.1021/jm0000416
CHEMBL120150 21281 0 None - 1 Human 9.3 pKi = 9.3 Binding
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 714 19 7 8 0.3 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CS(=O)(=O)O 10.1021/jm0000416
44271963 103500 0 None 4466 2 Human 9.3 pKi = 9.3 Binding
Displacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranesDisplacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranes
ChEMBL 1274 26 13 15 2.1 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCCNC(=O)[C@H](NC(=O)OC(C)(C)C)CCC(=O)N[C@H](Cc2ccc(OS(=O)(=O)O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccccc1)C(N)=O 10.1021/jm00126a007
CHEMBL264273 103500 0 None 4466 2 Human 9.3 pKi = 9.3 Binding
Displacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranesDisplacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranes
ChEMBL 1274 26 13 15 2.1 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCCNC(=O)[C@H](NC(=O)OC(C)(C)C)CCC(=O)N[C@H](Cc2ccc(OS(=O)(=O)O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccccc1)C(N)=O 10.1021/jm00126a007
10604664 162014 0 None 602 2 Human 9.3 pKi = 9.3 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 691 9 2 7 5.6 O=C(Nc1cccc(C(=O)OCCN2CCOCC2)c1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
CHEMBL402702 162014 0 None 602 2 Human 9.3 pKi = 9.3 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 691 9 2 7 5.6 O=C(Nc1cccc(C(=O)OCCN2CCOCC2)c1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
10792765 119857 0 None 2754 2 Human 9.2 pKi = 9.2 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 550 5 3 4 5.8 O=C(Nc1cccc(O)c1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
CHEMBL331244 119857 0 None 2754 2 Human 9.2 pKi = 9.2 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 550 5 3 4 5.8 O=C(Nc1cccc(O)c1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
4627 7609 50 None 1 5 Rat 9.2 pKi = 9.2 Binding
Affinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cellsAffinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cells
ChEMBL None None None None 10.1021/jm9603072
864 7609 50 None 1 5 Rat 9.2 pKi = 9.2 Binding
Affinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cellsAffinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cells
ChEMBL None None None None 10.1021/jm9603072
9833444 7609 50 None 1 5 Rat 9.2 pKi = 9.2 Binding
Affinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cellsAffinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cells
ChEMBL None None None None 10.1021/jm9603072
CHEMBL1121 7609 50 None 1 5 Rat 9.2 pKi = 9.2 Binding
Affinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cellsAffinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cells
ChEMBL None None None None 10.1021/jm9603072
DB09142 7609 50 None 1 5 Rat 9.2 pKi = 9.2 Binding
Affinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cellsAffinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cells
ChEMBL None None None None 10.1021/jm9603072
CHEMBL132314 215481 0 None 2 4 Human 9.2 pKi = 9.2 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor was determinedBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor was determined
ChEMBL None None None CCCC[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm0303103
4627 7609 50 None 1 5 Rat 9.2 pKi = 9.2 Binding
Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.
ChEMBL None None None None 10.1021/jm0000416
864 7609 50 None 1 5 Rat 9.2 pKi = 9.2 Binding
Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.
ChEMBL None None None None 10.1021/jm0000416
9833444 7609 50 None 1 5 Rat 9.2 pKi = 9.2 Binding
Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.
ChEMBL None None None None 10.1021/jm0000416
CHEMBL1121 7609 50 None 1 5 Rat 9.2 pKi = 9.2 Binding
Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.
ChEMBL None None None None 10.1021/jm0000416
DB09142 7609 50 None 1 5 Rat 9.2 pKi = 9.2 Binding
Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.
ChEMBL None None None None 10.1021/jm0000416
10768579 120643 0 None 32 2 Human 9.2 pKi = 9.2 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 531 6 2 4 5.5 CN(C)c1cccc(NC(=O)NC2C(=O)N(CCC(C)(C)C)c3ccccc3N(c3ccccc3F)C2=O)c1 10.1021/jm990967h
CHEMBL332568 120643 0 None 32 2 Human 9.2 pKi = 9.2 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 531 6 2 4 5.5 CN(C)c1cccc(NC(=O)NC2C(=O)N(CCC(C)(C)C)c3ccccc3N(c3ccccc3F)C2=O)c1 10.1021/jm990967h
4627 7609 50 None -1 5 Human 9.2 pKi = 9.2 Binding
Inhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptorInhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptor
ChEMBL None None None None 10.1021/jm9603072
864 7609 50 None -1 5 Human 9.2 pKi = 9.2 Binding
Inhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptorInhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptor
ChEMBL None None None None 10.1021/jm9603072
9833444 7609 50 None -1 5 Human 9.2 pKi = 9.2 Binding
Inhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptorInhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptor
ChEMBL None None None None 10.1021/jm9603072
CHEMBL1121 7609 50 None -1 5 Human 9.2 pKi = 9.2 Binding
Inhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptorInhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptor
ChEMBL None None None None 10.1021/jm9603072
DB09142 7609 50 None -1 5 Human 9.2 pKi = 9.2 Binding
Inhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptorInhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptor
ChEMBL None None None None 10.1021/jm9603072
16732911 149994 0 None 4 4 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 564 9 2 6 5.6 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(SCC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL389639 149994 0 None 4 4 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 564 9 2 6 5.6 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(SCC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
10838957 19244 0 None 151 2 Human 9.2 pKi = 9.2 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 495 5 2 4 5.2 CC(C)(C)CCN1C(=O)C(NC(=O)Nc2cccc(C#N)c2)C(=O)N(c2ccccc2)c2ccccc21 10.1021/jm990967h
CHEMBL118622 19244 0 None 151 2 Human 9.2 pKi = 9.2 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 495 5 2 4 5.2 CC(C)(C)CCN1C(=O)C(NC(=O)Nc2cccc(C#N)c2)C(=O)N(c2ccccc2)c2ccccc21 10.1021/jm990967h
4627 7609 50 None -1 5 Human 9.2 pKi = 9.2 Binding
The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL None None None None 10.1016/S0960-894X(00)80686-1
864 7609 50 None -1 5 Human 9.2 pKi = 9.2 Binding
The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL None None None None 10.1016/S0960-894X(00)80686-1
9833444 7609 50 None -1 5 Human 9.2 pKi = 9.2 Binding
The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL None None None None 10.1016/S0960-894X(00)80686-1
CHEMBL1121 7609 50 None -1 5 Human 9.2 pKi = 9.2 Binding
The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL None None None None 10.1016/S0960-894X(00)80686-1
DB09142 7609 50 None -1 5 Human 9.2 pKi = 9.2 Binding
The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL None None None None 10.1016/S0960-894X(00)80686-1
16732022 92286 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 601 8 2 7 6.3 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3csc(C(=O)O)n3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL227275 92286 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 601 8 2 7 6.3 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3csc(C(=O)O)n3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
10370321 19754 0 None 30902 2 Human 9.2 pKi = 9.2 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 550 5 3 4 5.8 O=C(Nc1ccc(O)cc1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
CHEMBL118954 19754 0 None 30902 2 Human 9.2 pKi = 9.2 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 550 5 3 4 5.8 O=C(Nc1ccc(O)cc1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
10555899 120150 0 None 2344 2 Human 9.2 pKi = 9.2 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 623 8 5 6 5.2 CC(O)C(O)Nc1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 10.1021/jm990967h
CHEMBL331763 120150 0 None 2344 2 Human 9.2 pKi = 9.2 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 623 8 5 6 5.2 CC(O)C(O)Nc1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 10.1021/jm990967h
10552321 170689 0 None 165 2 Human 9.2 pKi = 9.2 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 470 5 2 3 5.3 CC(C)(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21 10.1021/jm990967h
CHEMBL420728 170689 0 None 165 2 Human 9.2 pKi = 9.2 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 470 5 2 3 5.3 CC(C)(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21 10.1021/jm990967h
10792618 171132 0 None 70 2 Human 9.2 pKi = 9.2 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 543 7 2 4 5.7 CN(C)c1cccc(NC(=O)NC2C(=O)N(CCC3CCCC3)c3ccccc3N(c3ccccc3F)C2=O)c1 10.1021/jm990967h
CHEMBL421271 171132 0 None 70 2 Human 9.2 pKi = 9.2 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 543 7 2 4 5.7 CN(C)c1cccc(NC(=O)NC2C(=O)N(CCC3CCCC3)c3ccccc3N(c3ccccc3F)C2=O)c1 10.1021/jm990967h
4627 7609 50 None 1 5 Rat 9.2 pKi = 9.2 Binding
Ability to displace 1 nM [3H]pCCK-8 from rat Cholecystokinin type B receptor stably expressing in CHO cellsAbility to displace 1 nM [3H]pCCK-8 from rat Cholecystokinin type B receptor stably expressing in CHO cells
ChEMBL None None None None 10.1016/j.bmcl.2003.11.001
864 7609 50 None 1 5 Rat 9.2 pKi = 9.2 Binding
Ability to displace 1 nM [3H]pCCK-8 from rat Cholecystokinin type B receptor stably expressing in CHO cellsAbility to displace 1 nM [3H]pCCK-8 from rat Cholecystokinin type B receptor stably expressing in CHO cells
ChEMBL None None None None 10.1016/j.bmcl.2003.11.001
9833444 7609 50 None 1 5 Rat 9.2 pKi = 9.2 Binding
Ability to displace 1 nM [3H]pCCK-8 from rat Cholecystokinin type B receptor stably expressing in CHO cellsAbility to displace 1 nM [3H]pCCK-8 from rat Cholecystokinin type B receptor stably expressing in CHO cells
ChEMBL None None None None 10.1016/j.bmcl.2003.11.001
CHEMBL1121 7609 50 None 1 5 Rat 9.2 pKi = 9.2 Binding
Ability to displace 1 nM [3H]pCCK-8 from rat Cholecystokinin type B receptor stably expressing in CHO cellsAbility to displace 1 nM [3H]pCCK-8 from rat Cholecystokinin type B receptor stably expressing in CHO cells
ChEMBL None None None None 10.1016/j.bmcl.2003.11.001
DB09142 7609 50 None 1 5 Rat 9.2 pKi = 9.2 Binding
Ability to displace 1 nM [3H]pCCK-8 from rat Cholecystokinin type B receptor stably expressing in CHO cellsAbility to displace 1 nM [3H]pCCK-8 from rat Cholecystokinin type B receptor stably expressing in CHO cells
ChEMBL None None None None 10.1016/j.bmcl.2003.11.001
14802525 122255 1 None - 1 Mouse 9.2 pKi = 9.2 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 626 12 5 5 4.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CNC(=O)/C=C/C(=O)O)Cc1ccccc1 10.1021/jm00087a011
CHEMBL3351024 122255 1 None - 1 Mouse 9.2 pKi = 9.2 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 626 12 5 5 4.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CNC(=O)/C=C/C(=O)O)Cc1ccccc1 10.1021/jm00087a011
16732021 175255 0 None 549 2 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 588 9 2 8 5.3 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(SCc3nn[nH]n3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL435143 175255 0 None 549 2 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 588 9 2 8 5.3 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(SCc3nn[nH]n3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
9850043 119650 2 None 1 3 Human 9.2 pKi = 9.2 Binding
Inhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of guinea pigInhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of guinea pig
ChEMBL 534 5 2 3 6.1 O=C(Nc1ccccc1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
CHEMBL330977 119650 2 None 1 3 Human 9.2 pKi = 9.2 Binding
Inhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of guinea pigInhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of guinea pig
ChEMBL 534 5 2 3 6.1 O=C(Nc1ccccc1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
10767708 21318 0 None 138 2 Human 9.1 pKi = 9.1 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 500 6 2 3 5.6 O=C(Nc1ccccc1)NC1C(=O)N(CCC2CCCC2)c2ccccc2N(c2ccccc2F)C1=O 10.1021/jm990967h
CHEMBL120296 21318 0 None 138 2 Human 9.1 pKi = 9.1 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 500 6 2 3 5.6 O=C(Nc1ccccc1)NC1C(=O)N(CCC2CCCC2)c2ccccc2N(c2ccccc2F)C1=O 10.1021/jm990967h
10840039 120570 0 None 16 2 Human 9.1 pKi = 9.1 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 534 6 2 4 6.2 CSc1cccc(NC(=O)NC2C(=O)N(CCC(C)(C)C)c3ccccc3N(c3ccccc3F)C2=O)c1 10.1021/jm990967h
CHEMBL332403 120570 0 None 16 2 Human 9.1 pKi = 9.1 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 534 6 2 4 6.2 CSc1cccc(NC(=O)NC2C(=O)N(CCC(C)(C)C)c3ccccc3N(c3ccccc3F)C2=O)c1 10.1021/jm990967h
10723216 168774 0 None 4466 2 Mouse 9.1 pKi = 9.1 Binding
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 680 11 6 5 5.6 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2F)NC(=O)c2cc3cc[nH]c3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm9508907
CHEMBL415936 168774 0 None 4466 2 Mouse 9.1 pKi = 9.1 Binding
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 680 11 6 5 5.6 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2F)NC(=O)c2cc3cc[nH]c3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm9508907
5311400 10066 1 None -2 3 Rat 9.1 pKi = 9.1 Binding
Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.
ChEMBL None None None None 10.1021/jm0000416
900 10066 1 None -2 3 Rat 9.1 pKi = 9.1 Binding
Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.
ChEMBL None None None None 10.1021/jm0000416
CHEMBL262197 10066 1 None -2 3 Rat 9.1 pKi = 9.1 Binding
Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.
ChEMBL None None None None 10.1021/jm0000416
10554602 22065 0 None 29 2 Human 9.1 pKi = 9.1 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 546 7 2 4 6.3 CSc1cccc(NC(=O)NC2C(=O)N(CCC3CCCC3)c3ccccc3N(c3ccccc3F)C2=O)c1 10.1021/jm990967h
CHEMBL121331 22065 0 None 29 2 Human 9.1 pKi = 9.1 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 546 7 2 4 6.3 CSc1cccc(NC(=O)NC2C(=O)N(CCC3CCCC3)c3ccccc3N(c3ccccc3F)C2=O)c1 10.1021/jm990967h
16732165 175727 0 None 3235 2 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 571 8 2 6 5.5 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2ccc3c(ccn3CC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL438843 175727 0 None 3235 2 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 571 8 2 6 5.5 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2ccc3c(ccn3CC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
16732755 92225 0 None 10000 2 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 544 8 2 5 5.7 O=C(CN1N=C(C2CCCCC2)c2ccccc2N(CC(=O)C2CCCCC2)C1=O)Nc1cccc(C(=O)O)c1 10.1021/jm070139l
CHEMBL226622 92225 0 None 10000 2 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 544 8 2 5 5.7 O=C(CN1N=C(C2CCCCC2)c2ccccc2N(CC(=O)C2CCCCC2)C1=O)Nc1cccc(C(=O)O)c1 10.1021/jm070139l
CHEMBL333477 218171 0 None 3 3 Human 9.1 pKi = 9.1 Binding
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm0000416
CHEMBL2372784 217069 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N(C)[C@@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C 10.1021/jm00053a022
CHEMBL333477 218171 0 None 3 3 Human 9.1 pKi = 9.1 Binding
Inhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptorInhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptor
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm9603072
16732444 150084 0 None 2570 2 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 572 8 2 7 4.9 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2ccc3cnn(CC(=O)O)c3c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL389713 150084 0 None 2570 2 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 572 8 2 7 4.9 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2ccc3cnn(CC(=O)O)c3c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
10722460 21964 0 None 309 2 Human 9.1 pKi = 9.1 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 612 5 2 3 6.9 O=C(Nc1cccc(Br)c1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
CHEMBL121028 21964 0 None 309 2 Human 9.1 pKi = 9.1 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 612 5 2 3 6.9 O=C(Nc1cccc(Br)c1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
44461961 112386 0 None 9 3 Mouse 9.1 pKi = 9.1 Binding
Binding affinity towards CCK-B receptor in mouse cerebral cortex membrane using [125I]bolton assayBinding affinity towards CCK-B receptor in mouse cerebral cortex membrane using [125I]bolton assay
ChEMBL 724 11 4 5 6.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccc(N=[N+]=[N-])c(I)c1 10.1016/0960-894X(95)00435-V
CHEMBL2079605 112386 0 None 9 3 Mouse 9.1 pKi = 9.1 Binding
Binding affinity towards CCK-B receptor in mouse cerebral cortex membrane using [125I]bolton assayBinding affinity towards CCK-B receptor in mouse cerebral cortex membrane using [125I]bolton assay
ChEMBL 724 11 4 5 6.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccc(N=[N+]=[N-])c(I)c1 10.1016/0960-894X(95)00435-V
CHEMBL312252 112386 0 None 9 3 Mouse 9.1 pKi = 9.1 Binding
Binding affinity towards CCK-B receptor in mouse cerebral cortex membrane using [125I]bolton assayBinding affinity towards CCK-B receptor in mouse cerebral cortex membrane using [125I]bolton assay
ChEMBL 724 11 4 5 6.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccc(N=[N+]=[N-])c(I)c1 10.1016/0960-894X(95)00435-V
44451581 102600 0 None 5 3 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 594 9 2 6 6.0 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(SCC(=O)O)c2)C(=O)N(C2CCCCCC2)c2ccccc21 10.1016/j.bmc.2007.12.047
CHEMBL258863 102600 0 None 5 3 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 594 9 2 6 6.0 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(SCC(=O)O)c2)C(=O)N(C2CCCCCC2)c2ccccc21 10.1016/j.bmc.2007.12.047
16733310 175623 0 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 597 9 2 6 6.0 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3cccn3CC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL437930 175623 0 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 597 9 2 6 6.0 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3cccn3CC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
9850043 119650 2 None 1 3 Human 9.0 pKi = 9.0 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 534 5 2 3 6.1 O=C(Nc1ccccc1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
CHEMBL330977 119650 2 None 1 3 Human 9.0 pKi = 9.0 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 534 5 2 3 6.1 O=C(Nc1ccccc1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
3503 8674 16 None 1174 2 Human 9.0 pKi = 9.0 Binding
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 534 5 2 3 6.1 O=C(N[C@H]1C(=O)N(c2ccccc2)c2c(N(C1=O)CC13CC4CC(C3)CC(C1)C4)cccc2)Nc1ccccc1 10.1016/S0960-894X(96)00544-6
5311147 8674 16 None 1174 2 Human 9.0 pKi = 9.0 Binding
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 534 5 2 3 6.1 O=C(N[C@H]1C(=O)N(c2ccccc2)c2c(N(C1=O)CC13CC4CC(C3)CC(C1)C4)cccc2)Nc1ccccc1 10.1016/S0960-894X(96)00544-6
CHEMBL329305 8674 16 None 1174 2 Human 9.0 pKi = 9.0 Binding
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 534 5 2 3 6.1 O=C(N[C@H]1C(=O)N(c2ccccc2)c2c(N(C1=O)CC13CC4CC(C3)CC(C1)C4)cccc2)Nc1ccccc1 10.1016/S0960-894X(96)00544-6
10696354 120267 0 None 74 2 Human 9.0 pKi = 9.0 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 488 5 2 3 5.5 CC(C)(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2F)c2ccccc21 10.1021/jm990967h
CHEMBL331971 120267 0 None 74 2 Human 9.0 pKi = 9.0 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 488 5 2 3 5.5 CC(C)(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2F)c2ccccc21 10.1021/jm990967h
44346296 121275 0 None 1174 2 Human 9.0 pKi = 9.0 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 562 6 2 4 5.9 O=Cc1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 10.1021/jm990967h
CHEMBL333517 121275 0 None 1174 2 Human 9.0 pKi = 9.0 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 562 6 2 4 5.9 O=Cc1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 10.1021/jm990967h
10698427 21326 0 None 645 2 Human 9.0 pKi = 9.0 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 578 6 3 4 5.8 O=C(Nc1cccc(C(=O)O)c1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
CHEMBL120363 21326 0 None 645 2 Human 9.0 pKi = 9.0 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 578 6 3 4 5.8 O=C(Nc1cccc(C(=O)O)c1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
108187 7713 37 None -4 5 Human 9.0 pKi = 9.0 Binding
The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1016/S0960-894X(00)80686-1
873 7713 37 None -4 5 Human 9.0 pKi = 9.0 Binding
The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1016/S0960-894X(00)80686-1
CHEMBL2062154 7713 37 None -4 5 Human 9.0 pKi = 9.0 Binding
The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1016/S0960-894X(00)80686-1
CHEMBL287735 7713 37 None -4 5 Human 9.0 pKi = 9.0 Binding
The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1016/S0960-894X(00)80686-1
11527738 82764 0 None -2 4 Human 9.0 pKi = 9 Binding
Binding affinity at human CCK2 receptorBinding affinity at human CCK2 receptor
ChEMBL 518 7 2 5 5.2 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1016/j.bmc.2007.12.047
CHEMBL205455 82764 0 None -2 4 Human 9.0 pKi = 9 Binding
Binding affinity at human CCK2 receptorBinding affinity at human CCK2 receptor
ChEMBL 518 7 2 5 5.2 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1016/j.bmc.2007.12.047
44572200 186122 0 None 14 2 Human 9.0 pKi = 9 Binding
Displacement of [125I](R)-1-(3-iodophenyl)-3-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1Hbenzo[e][1,4]diazepin-3-yl)urea from human CCK2 receptor expressed in CHO cells by gamma spectrometryDisplacement of [125I](R)-1-(3-iodophenyl)-3-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1Hbenzo[e][1,4]diazepin-3-yl)urea from human CCK2 receptor expressed in CHO cells by gamma spectrometry
ChEMBL 510 3 2 3 4.3 CN1C(=O)[C@@H](NC(=O)Nc2cccc(I)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm801439x
CHEMBL473612 186122 0 None 14 2 Human 9.0 pKi = 9 Binding
Displacement of [125I](R)-1-(3-iodophenyl)-3-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1Hbenzo[e][1,4]diazepin-3-yl)urea from human CCK2 receptor expressed in CHO cells by gamma spectrometryDisplacement of [125I](R)-1-(3-iodophenyl)-3-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1Hbenzo[e][1,4]diazepin-3-yl)urea from human CCK2 receptor expressed in CHO cells by gamma spectrometry
ChEMBL 510 3 2 3 4.3 CN1C(=O)[C@@H](NC(=O)Nc2cccc(I)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm801439x
CHEMBL475226 186122 0 None 14 2 Human 9.0 pKi = 9 Binding
Displacement of [125I](R)-1-(3-iodophenyl)-3-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1Hbenzo[e][1,4]diazepin-3-yl)urea from human CCK2 receptor expressed in CHO cells by gamma spectrometryDisplacement of [125I](R)-1-(3-iodophenyl)-3-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1Hbenzo[e][1,4]diazepin-3-yl)urea from human CCK2 receptor expressed in CHO cells by gamma spectrometry
ChEMBL 510 3 2 3 4.3 CN1C(=O)[C@@H](NC(=O)Nc2cccc(I)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm801439x
16732019 92209 0 None 3 4 Human 9.0 pKi = 9 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 542 7 2 7 4.6 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nn[nH]n3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL226533 92209 0 None 3 4 Human 9.0 pKi = 9 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 542 7 2 7 4.6 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nn[nH]n3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
16731872 92224 0 None 1 3 Human 9.0 pKi = 9 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 530 8 2 5 5.3 O=C(CN1N=C(C2CCCCC2)c2ccccc2N(CC(=O)C2CCCC2)C1=O)Nc1cccc(C(=O)O)c1 10.1021/jm070139l
CHEMBL226620 92224 0 None 1 3 Human 9.0 pKi = 9 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 530 8 2 5 5.3 O=C(CN1N=C(C2CCCCC2)c2ccccc2N(CC(=O)C2CCCC2)C1=O)Nc1cccc(C(=O)O)c1 10.1021/jm070139l
CHEMBL2372780 217066 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL None None None CCCC[C@H](NC(=O)CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCC)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC)C(=O)N[C@@H](Cc1ccc(S(=O)(=O)O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)O 10.1021/jm00053a022
9939572 44265 0 None 21 3 Mouse 9.0 pKi = 9 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 662 11 6 5 5.5 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3cc[nH]c3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL14557 44265 0 None 21 3 Mouse 9.0 pKi = 9 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 662 11 6 5 5.5 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3cc[nH]c3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL2067949 44265 0 None 21 3 Mouse 9.0 pKi = 9 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 662 11 6 5 5.5 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3cc[nH]c3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm049069y
44346345 119861 0 None 43 2 Human 9.0 pKi = 9.0 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 523 5 2 4 5.1 CN(C)c1cccc(NC(=O)NC2C(=O)N(c3ccccc3)c3ccccc3N(C3CC4CCC3C4)C2=O)c1 10.1021/jm990967h
CHEMBL331262 119861 0 None 43 2 Human 9.0 pKi = 9.0 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 523 5 2 4 5.1 CN(C)c1cccc(NC(=O)NC2C(=O)N(c3ccccc3)c3ccccc3N(C3CC4CCC3C4)C2=O)c1 10.1021/jm990967h
16732017 92242 0 None 6025 2 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 561 9 2 6 5.0 CN(CC(=O)O)c1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm070139l
CHEMBL226726 92242 0 None 6025 2 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 561 9 2 6 5.0 CN(CC(=O)O)c1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm070139l
9939572 44265 0 None 21 3 Mouse 9.0 pKi = 9.0 Binding
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 662 11 6 5 5.5 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3cc[nH]c3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm9508907
CHEMBL14557 44265 0 None 21 3 Mouse 9.0 pKi = 9.0 Binding
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 662 11 6 5 5.5 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3cc[nH]c3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm9508907
CHEMBL2067949 44265 0 None 21 3 Mouse 9.0 pKi = 9.0 Binding
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 662 11 6 5 5.5 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3cc[nH]c3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm9508907
CHEMBL218327 216173 0 None -2 4 Human 9.0 pKi = 9.0 Binding
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
9939572 44265 0 None 21 3 Mouse 9.0 pKi = 9.0 Binding
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 662 11 6 5 5.5 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3cc[nH]c3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm000960w
CHEMBL14557 44265 0 None 21 3 Mouse 9.0 pKi = 9.0 Binding
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 662 11 6 5 5.5 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3cc[nH]c3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm000960w
CHEMBL2067949 44265 0 None 21 3 Mouse 9.0 pKi = 9.0 Binding
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 662 11 6 5 5.5 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3cc[nH]c3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm000960w
10579091 21144 0 None 398 2 Human 9.0 pKi = 9.0 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 577 6 2 4 6.2 CN(C)c1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 10.1021/jm990967h
CHEMBL120021 21144 0 None 398 2 Human 9.0 pKi = 9.0 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 577 6 2 4 6.2 CN(C)c1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 10.1021/jm990967h
10552320 124237 0 None 109 2 Human 9.0 pKi = 9.0 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 470 6 2 3 5.2 CC(C)C(C)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21 10.1021/jm990967h
CHEMBL339879 124237 0 None 109 2 Human 9.0 pKi = 9.0 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 470 6 2 3 5.2 CC(C)C(C)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21 10.1021/jm990967h
10415968 122245 0 None - 1 Mouse 8.9 pKi = 8.9 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 588 12 5 5 4.3 C[C@@H]1CCCC[C@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CNC(=O)/C=C/C(=O)O)Cc1ccccc1 10.1021/jm00087a011
CHEMBL3351013 122245 0 None - 1 Mouse 8.9 pKi = 8.9 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 588 12 5 5 4.3 C[C@@H]1CCCC[C@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CNC(=O)/C=C/C(=O)O)Cc1ccccc1 10.1021/jm00087a011
118727697 124368 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of Eu-DTPA-PEGO-CCK4 from human cholecystokinin 2 receptor overexpressed in HEK-293 cells co-expressing human MC4R after 1 hr by time resolved fluorescence-based competition binding assayDisplacement of Eu-DTPA-PEGO-CCK4 from human cholecystokinin 2 receptor overexpressed in HEK-293 cells co-expressing human MC4R after 1 hr by time resolved fluorescence-based competition binding assay
ChEMBL 2115 63 21 28 0.8 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)Cn1cc(CN(Cc2cn(CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc3ccccc3)C(N)=O)nn2)Cc2cn(CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc3ccccc3)C(N)=O)nn2)nn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmc.2015.02.028
CHEMBL3400295 124368 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of Eu-DTPA-PEGO-CCK4 from human cholecystokinin 2 receptor overexpressed in HEK-293 cells co-expressing human MC4R after 1 hr by time resolved fluorescence-based competition binding assayDisplacement of Eu-DTPA-PEGO-CCK4 from human cholecystokinin 2 receptor overexpressed in HEK-293 cells co-expressing human MC4R after 1 hr by time resolved fluorescence-based competition binding assay
ChEMBL 2115 63 21 28 0.8 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)Cn1cc(CN(Cc2cn(CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc3ccccc3)C(N)=O)nn2)Cc2cn(CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc3ccccc3)C(N)=O)nn2)nn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmc.2015.02.028
136036823 162457 0 None 37 3 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 574 7 2 7 4.8 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nc(=O)o[nH]3)c2)C(=O)N(C2CCCCC2)c2ccccc21 10.1016/j.bmc.2007.12.047
CHEMBL404967 162457 0 None 37 3 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 574 7 2 7 4.8 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nc(=O)o[nH]3)c2)C(=O)N(C2CCCCC2)c2ccccc21 10.1016/j.bmc.2007.12.047
44425006 148858 0 None 3311 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 544 8 2 5 5.6 CC1CCCC1C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL388068 148858 0 None 3311 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 544 8 2 5 5.6 CC1CCCC1C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
9853208 108501 0 None 1071 2 Mouse 8.9 pKi = 8.9 Binding
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 710 11 6 9 4.5 O=C(NCC12CC3CC(CC(C3)C1)C2)c1cc2[nH]ccc2cc1C(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1cc(-c2nn[nH]n2)cc(-c2nn[nH]n2)c1 10.1021/jm9508907
CHEMBL299540 108501 0 None 1071 2 Mouse 8.9 pKi = 8.9 Binding
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 710 11 6 9 4.5 O=C(NCC12CC3CC(CC(C3)C1)C2)c1cc2[nH]ccc2cc1C(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1cc(-c2nn[nH]n2)cc(-c2nn[nH]n2)c1 10.1021/jm9508907
10652142 108347 0 None 1819 2 Mouse 8.9 pKi = 8.9 Binding
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 679 11 5 6 6.2 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3ccsc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm9508907
CHEMBL298521 108347 0 None 1819 2 Mouse 8.9 pKi = 8.9 Binding
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 679 11 5 6 6.2 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3ccsc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm9508907
10555899 120150 0 None 2344 2 Human 8.9 pKi = 8.9 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 623 8 5 6 5.2 CC(O)C(O)Nc1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 10.1021/jm990967h
CHEMBL331763 120150 0 None 2344 2 Human 8.9 pKi = 8.9 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 623 8 5 6 5.2 CC(O)C(O)Nc1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 10.1021/jm990967h
11801315 121552 0 None 50 2 Human 8.9 pKi = 8.9 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 577 6 2 4 6.0 CN(C)c1cccc(NC(=O)NC2C(=O)N(CC3[C@H]4C[C@@H]5C[C@@H](C[C@H]3C5)C4)c3ccccc3N(c3ccccc3)C2=O)c1 10.1021/jm990967h
CHEMBL333930 121552 0 None 50 2 Human 8.9 pKi = 8.9 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 577 6 2 4 6.0 CN(C)c1cccc(NC(=O)NC2C(=O)N(CC3[C@H]4C[C@@H]5C[C@@H](C[C@H]3C5)C4)c3ccccc3N(c3ccccc3)C2=O)c1 10.1021/jm990967h
44357046 34832 2 None -18 2 Rat 8.9 pKi = 8.9 Binding
Binding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomesBinding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomes
ChEMBL 1012 28 9 13 0.7 CSCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm970477u
CHEMBL137280 34832 2 None -18 2 Rat 8.9 pKi = 8.9 Binding
Binding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomesBinding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomes
ChEMBL 1012 28 9 13 0.7 CSCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm970477u
CHEMBL206974 215961 0 None 1 5 Human 8.9 pKi = 8.9 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor was determinedBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor was determined
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm0303103
CHEMBL336381 218362 0 None 97 5 Human 8.9 pKi = 8.9 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor was determinedBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor was determined
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm0303103
10769748 119784 0 None 1148 2 Human 8.9 pKi = 8.9 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 591 6 3 4 6.1 CC(=O)Nc1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 10.1021/jm990967h
CHEMBL331119 119784 0 None 1148 2 Human 8.9 pKi = 8.9 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 591 6 3 4 6.1 CC(=O)Nc1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 10.1021/jm990967h
10604418 19228 0 None - 1 Human 8.9 pKi = 8.9 Binding
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 662 18 6 6 2.0 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)C 10.1021/jm0000416
CHEMBL118610 19228 0 None - 1 Human 8.9 pKi = 8.9 Binding
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 662 18 6 6 2.0 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)C 10.1021/jm0000416
10098459 11038 0 None 208 2 Human 8.9 pKi = 8.9 Binding
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 528 7 2 3 5.8 CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc21 10.1016/S0960-894X(96)00544-6
CHEMBL100548 11038 0 None 208 2 Human 8.9 pKi = 8.9 Binding
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 528 7 2 3 5.8 CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc21 10.1016/S0960-894X(96)00544-6
10508004 18571 0 None 2454 2 Human 8.9 pKi = 8.9 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 612 5 2 3 6.9 O=C(Nc1ccc(Br)cc1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
CHEMBL118189 18571 0 None 2454 2 Human 8.9 pKi = 8.9 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 612 5 2 3 6.9 O=C(Nc1ccc(Br)cc1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
108187 7713 37 None -9 5 Mouse 8.8 pKi = 8.8 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm00087a011
873 7713 37 None -9 5 Mouse 8.8 pKi = 8.8 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm00087a011
CHEMBL2062154 7713 37 None -9 5 Mouse 8.8 pKi = 8.8 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm00087a011
CHEMBL287735 7713 37 None -9 5 Mouse 8.8 pKi = 8.8 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm00087a011
CHEMBL206974 215961 0 None 1 5 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
44346255 123659 0 None 30 2 Human 8.8 pKi = 8.8 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 564 6 2 7 6.7 CC(C)(C1CCCC1)N1C(=O)C(NC(=O)Nc2cccc(C3N=NN=N3)c2)C(=O)N(c2ccccc2)c2ccccc21 10.1021/jm990967h
CHEMBL338278 123659 0 None 30 2 Human 8.8 pKi = 8.8 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 564 6 2 7 6.7 CC(C)(C1CCCC1)N1C(=O)C(NC(=O)Nc2cccc(C3N=NN=N3)c2)C(=O)N(c2ccccc2)c2ccccc21 10.1021/jm990967h
10004216 11515 0 None 11 2 Human 8.8 pKi = 8.8 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 456 6 2 3 4.9 CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21 10.1021/jm990967h
CHEMBL103750 11515 0 None 11 2 Human 8.8 pKi = 8.8 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 456 6 2 3 4.9 CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21 10.1021/jm990967h
10792724 21182 0 None 162 2 Human 8.8 pKi = 8.8 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 548 5 2 3 6.4 Cc1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 10.1021/jm990967h
CHEMBL120031 21182 0 None 162 2 Human 8.8 pKi = 8.8 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 548 5 2 3 6.4 Cc1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 10.1021/jm990967h
19043400 105518 0 None 162 2 Human 8.8 pKi = 8.8 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 480 4 2 3 5.1 O=C(Nc1ccccc1)NC1C(=O)N(c2ccccc2)c2ccccc2N(C2CC3CCC2C3)C1=O 10.1021/jm990967h
CHEMBL278018 105518 0 None 162 2 Human 8.8 pKi = 8.8 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 480 4 2 3 5.1 O=C(Nc1ccccc1)NC1C(=O)N(c2ccccc2)c2ccccc2N(C2CC3CCC2C3)C1=O 10.1021/jm990967h
10795162 125816 0 None 630 2 Mouse 8.8 pKi = 8.8 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 751 11 5 5 6.6 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm00021a019
CHEMBL2067970 125816 0 None 630 2 Mouse 8.8 pKi = 8.8 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 751 11 5 5 6.6 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm00021a019
CHEMBL342616 125816 0 None 630 2 Mouse 8.8 pKi = 8.8 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 751 11 5 5 6.6 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm00021a019
16733185 148870 0 None 346 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 594 8 2 5 6.8 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3cccc(C(=O)O)c3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL388143 148870 0 None 346 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 594 8 2 5 6.8 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3cccc(C(=O)O)c3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
44296914 108026 0 None 1318 2 Mouse 8.8 pKi = 8.8 Binding
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 765 12 5 5 7.0 O=C(CC1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC12CC3CC(CC(C3)C1)C2)N[C@@H](Cc1ccccc1)C(=O)Nc1cc(C(=O)O)cc(C(=O)O)c1 10.1021/jm9508907
CHEMBL296167 108026 0 None 1318 2 Mouse 8.8 pKi = 8.8 Binding
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 765 12 5 5 7.0 O=C(CC1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC12CC3CC(CC(C3)C1)C2)N[C@@H](Cc1ccccc1)C(=O)Nc1cc(C(=O)O)cc(C(=O)O)c1 10.1021/jm9508907
5311201 214174 35 None -27 6 Human 8.8 pKi = 8.8 Binding
Inhibition by displacing [3H]CCK-8S against human Cholecystokinin type B receptorInhibition by displacing [3H]CCK-8S against human Cholecystokinin type B receptor
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm990967h
CHEMBL9387 214174 35 None -27 6 Human 8.8 pKi = 8.8 Binding
Inhibition by displacing [3H]CCK-8S against human Cholecystokinin type B receptorInhibition by displacing [3H]CCK-8S against human Cholecystokinin type B receptor
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm990967h
10795162 125816 0 None 630 2 Mouse 8.8 pKi = 8.8 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 751 11 5 5 6.6 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL2067970 125816 0 None 630 2 Mouse 8.8 pKi = 8.8 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 751 11 5 5 6.6 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL342616 125816 0 None 630 2 Mouse 8.8 pKi = 8.8 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 751 11 5 5 6.6 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm049069y
44329156 214413 0 None 50 2 Human 8.8 pKi = 8.8 Binding
Tested for its selectivity against human Cholecystokinin type B receptor isolated from a human temporal cortex cDNA library and stably transfected into a HeLa cell line. (n=1)Tested for its selectivity against human Cholecystokinin type B receptor isolated from a human temporal cortex cDNA library and stably transfected into a HeLa cell line. (n=1)
ChEMBL 535 5 2 4 4.0 O=C(Nc1ccc(F)cc1)N[C@H]1C(=O)N(CC(=O)N2CCCC2)c2ccccc2N(C2CCCCCC2)C1=O 10.1016/S0960-894X(96)00613-0
CHEMBL95200 214413 0 None 50 2 Human 8.8 pKi = 8.8 Binding
Tested for its selectivity against human Cholecystokinin type B receptor isolated from a human temporal cortex cDNA library and stably transfected into a HeLa cell line. (n=1)Tested for its selectivity against human Cholecystokinin type B receptor isolated from a human temporal cortex cDNA library and stably transfected into a HeLa cell line. (n=1)
ChEMBL 535 5 2 4 4.0 O=C(Nc1ccc(F)cc1)N[C@H]1C(=O)N(CC(=O)N2CCCC2)c2ccccc2N(C2CCCCCC2)C1=O 10.1016/S0960-894X(96)00613-0
CHEMBL430298 220397 0 None -3 4 Human 8.8 pKi = 8.8 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor was determinedBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor was determined
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm0303103
CHEMBL382349 219081 0 None 1 4 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
44379188 64258 0 None - 1 Human 8.8 pKi = 8.8 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 614 11 4 7 4.5 C[C@@](N)(Cc1cn(C(=O)OC2C3CC4CC(C3)CC2C4)c2ccccc12)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1 10.1016/S0960-894X(00)80669-1
CHEMBL165869 64258 0 None - 1 Human 8.8 pKi = 8.8 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 614 11 4 7 4.5 C[C@@](N)(Cc1cn(C(=O)OC2C3CC4CC(C3)CC2C4)c2ccccc12)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1 10.1016/S0960-894X(00)80669-1
44346126 22038 0 None 27 2 Human 8.8 pKi = 8.8 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 514 4 2 3 5.7 O=C(Nc1cccc(Cl)c1)NC1C(=O)N(c2ccccc2)c2ccccc2N(C2CC3CCC2C3)C1=O 10.1021/jm990967h
CHEMBL121267 22038 0 None 27 2 Human 8.8 pKi = 8.8 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 514 4 2 3 5.7 O=C(Nc1cccc(Cl)c1)NC1C(=O)N(c2ccccc2)c2ccccc2N(C2CC3CCC2C3)C1=O 10.1021/jm990967h
5311201 214174 35 None -27 6 Human 8.7 pKi = 8.7 Binding
The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(00)80686-1
CHEMBL9387 214174 35 None -27 6 Human 8.7 pKi = 8.7 Binding
The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(00)80686-1
10723875 21714 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 767 21 7 7 2.1 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(=O)NCc1ccccc1 10.1021/jm0000416
CHEMBL120827 21714 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 767 21 7 7 2.1 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(=O)NCc1ccccc1 10.1021/jm0000416
16731874 92233 0 None 2 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 546 9 2 5 5.5 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CCC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL226675 92233 0 None 2 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 546 9 2 5 5.5 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CCC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
9958214 121571 0 None 269 2 Human 8.7 pKi = 8.7 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 517 7 2 4 5.1 CC(C)CCN1C(=O)C(NC(=O)Nc2cccc(N(C)C)c2)C(=O)N(c2ccccc2F)c2ccccc21 10.1021/jm990967h
CHEMBL333979 121571 0 None 269 2 Human 8.7 pKi = 8.7 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 517 7 2 4 5.1 CC(C)CCN1C(=O)C(NC(=O)Nc2cccc(N(C)C)c2)C(=O)N(c2ccccc2F)c2ccccc21 10.1021/jm990967h
108187 7713 37 None -4 5 Human 8.7 pKi = 8.7 Binding
Inhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of guinea pigInhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of guinea pig
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm990967h
873 7713 37 None -4 5 Human 8.7 pKi = 8.7 Binding
Inhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of guinea pigInhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of guinea pig
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm990967h
CHEMBL2062154 7713 37 None -4 5 Human 8.7 pKi = 8.7 Binding
Inhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of guinea pigInhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of guinea pig
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm990967h
CHEMBL287735 7713 37 None -4 5 Human 8.7 pKi = 8.7 Binding
Inhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of guinea pigInhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of guinea pig
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm990967h
44351445 123712 0 None 1 2 Human 8.7 pKi = 8.7 Binding
Binding affinity (affinity state 1) for Cholecystokinin type B receptor, was determined using CHO cellsBinding affinity (affinity state 1) for Cholecystokinin type B receptor, was determined using CHO cells
ChEMBL 654 8 3 6 5.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(Cl)cc2Cl)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL338525 123712 0 None 1 2 Human 8.7 pKi = 8.7 Binding
Binding affinity (affinity state 1) for Cholecystokinin type B receptor, was determined using CHO cellsBinding affinity (affinity state 1) for Cholecystokinin type B receptor, was determined using CHO cells
ChEMBL 654 8 3 6 5.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(Cl)cc2Cl)C[C@@H]1C(=O)O 10.1021/jm970439a
10793342 119882 0 None 158 2 Human 8.7 pKi = 8.7 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 579 6 2 5 6.0 O=C(Nc1cccc([N+](=O)[O-])c1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
CHEMBL331405 119882 0 None 158 2 Human 8.7 pKi = 8.7 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 579 6 2 5 6.0 O=C(Nc1cccc([N+](=O)[O-])c1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
16732020 92285 0 None 2 4 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 571 8 2 8 4.7 CN(c1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1)c1nn[nH]n1 10.1021/jm070139l
CHEMBL227254 92285 0 None 2 4 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 571 8 2 8 4.7 CN(c1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1)c1nn[nH]n1 10.1021/jm070139l
10768658 121580 0 None 42 2 Human 8.7 pKi = 8.7 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 534 5 2 3 6.0 O=C(Nc1ccccc1)NC1C(=O)N(CC2[C@H]3C[C@@H]4C[C@@H](C[C@H]2C4)C3)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
CHEMBL334020 121580 0 None 42 2 Human 8.7 pKi = 8.7 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 534 5 2 3 6.0 O=C(Nc1ccccc1)NC1C(=O)N(CC2[C@H]3C[C@@H]4C[C@@H](C[C@H]2C4)C3)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
9960432 46198 5 None 12 2 Human 8.0 pKi = 8 Binding
Binding affinity at human CCK2 receptorBinding affinity at human CCK2 receptor
ChEMBL 605 8 3 5 5.0 CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C(=O)O)c2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1016/j.bmc.2007.12.047
CHEMBL147186 46198 5 None 12 2 Human 8.0 pKi = 8 Binding
Binding affinity at human CCK2 receptorBinding affinity at human CCK2 receptor
ChEMBL 605 8 3 5 5.0 CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C(=O)O)c2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1016/j.bmc.2007.12.047
45486935 203538 0 None 25 2 Human 8.0 pKi = 8 Binding
Displacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation counting
ChEMBL 612 8 3 7 4.5 O=C(N[C@@H](Cc1ccc(F)c(Br)c1)C(=O)O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.065
CHEMBL565298 203538 0 None 25 2 Human 8.0 pKi = 8 Binding
Displacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation counting
ChEMBL 612 8 3 7 4.5 O=C(N[C@@H](Cc1ccc(F)c(Br)c1)C(=O)O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.065
45102806 203542 0 None 15 2 Human 8.0 pKi = 8 Binding
Displacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation counting
ChEMBL 646 8 3 7 5.1 O=C(N[C@@H](Cc1ccc(F)c(Br)c1)C(=O)O)c1cc(Cl)c(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.065
CHEMBL565324 203542 0 None 15 2 Human 8.0 pKi = 8 Binding
Displacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation counting
ChEMBL 646 8 3 7 5.1 O=C(N[C@@H](Cc1ccc(F)c(Br)c1)C(=O)O)c1cc(Cl)c(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.065
45486964 204173 0 None 39 2 Human 8.0 pKi = 8 Binding
Displacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation counting
ChEMBL 606 8 3 6 4.4 O=C(N[C@@H](Cc1ccc(F)c(Br)c1)C(=O)O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nccnc12 10.1016/j.bmcl.2009.09.065
CHEMBL569391 204173 0 None 39 2 Human 8.0 pKi = 8 Binding
Displacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation counting
ChEMBL 606 8 3 6 4.4 O=C(N[C@@H](Cc1ccc(F)c(Br)c1)C(=O)O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nccnc12 10.1016/j.bmcl.2009.09.065
45487006 205691 0 None 10 2 Human 8.0 pKi = 8 Binding
Displacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation counting
ChEMBL 666 8 3 6 5.0 O=C(N[C@@H](Cc1ccc(Cl)c(Br)c1)C(=O)O)c1ccc(Br)cc1NS(=O)(=O)c1cccc2nccnc12 10.1016/j.bmcl.2009.09.065
CHEMBL584525 205691 0 None 10 2 Human 8.0 pKi = 8 Binding
Displacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation counting
ChEMBL 666 8 3 6 5.0 O=C(N[C@@H](Cc1ccc(Cl)c(Br)c1)C(=O)O)c1ccc(Br)cc1NS(=O)(=O)c1cccc2nccnc12 10.1016/j.bmcl.2009.09.065
11786290 87323 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 558 4 1 6 4.6 O=C(c1cc(Br)c(Br)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
CHEMBL214836 87323 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 558 4 1 6 4.6 O=C(c1cc(Br)c(Br)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
10004216 11515 0 None 11 2 Human 8.0 pKi = 8 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 456 6 2 3 4.9 CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21 10.1021/jm990967h
CHEMBL103750 11515 0 None 11 2 Human 8.0 pKi = 8 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 456 6 2 3 4.9 CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21 10.1021/jm990967h
CHEMBL120632 215384 33 None 5 3 Human 8.0 pKi = 8.0 Binding
Displacement of non-sulfated CCK-8 from CCKB receptor (unknown origin) expressed in HEK cells after 4 hrs by RP-LC-ICPMS analysisDisplacement of non-sulfated CCK-8 from CCKB receptor (unknown origin) expressed in HEK cells after 4 hrs by RP-LC-ICPMS analysis
ChEMBL None None None CSCC[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01320
10747599 32632 0 None 46 2 Mouse 8.0 pKi = 8.0 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 743 11 5 5 6.7 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCc2cccc3ccccc23)cc(C(=O)O)c1 10.1021/jm00021a019
CHEMBL135350 32632 0 None 46 2 Mouse 8.0 pKi = 8.0 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 743 11 5 5 6.7 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCc2cccc3ccccc23)cc(C(=O)O)c1 10.1021/jm00021a019
44331506 114062 0 None 22 2 Human 8.0 pKi = 8.0 Binding
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 574 5 2 3 6.8 O=C(Nc1cccc(Cl)c1)NC1C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc2N(C2CCCCC2)C1=O 10.1016/S0960-894X(96)00544-6
CHEMBL317108 114062 0 None 22 2 Human 8.0 pKi = 8.0 Binding
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 574 5 2 3 6.8 O=C(Nc1cccc(Cl)c1)NC1C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc2N(C2CCCCC2)C1=O 10.1016/S0960-894X(96)00544-6
CHEMBL1172249 215361 0 None -16 4 Human 7.0 pKi = 7 Binding
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H]1Cc2ccccc2CN1C(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2010.05.078
16090780 87107 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 494 4 1 6 4.2 Cc1ccc(S(=O)(=O)Nc2cc(Br)ccc2C(=O)N2CCCCC2)c2nsnc12 10.1021/jm060590x
CHEMBL214235 87107 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 494 4 1 6 4.2 Cc1ccc(S(=O)(=O)Nc2cc(Br)ccc2C(=O)N2CCCCC2)c2nsnc12 10.1021/jm060590x
16090684 89057 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 494 4 1 6 4.2 Cc1ccc2nsnc2c1S(=O)(=O)Nc1cc(Br)ccc1C(=O)N1CCCCC1 10.1021/jm060590x
CHEMBL217170 89057 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 494 4 1 6 4.2 Cc1ccc2nsnc2c1S(=O)(=O)Nc1cc(Br)ccc1C(=O)N1CCCCC1 10.1021/jm060590x
44417429 148170 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 448 5 2 7 3.5 O=C(c1ccc(CS)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
CHEMBL383919 148170 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 448 5 2 7 3.5 O=C(c1ccc(CS)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
45486970 204408 0 None 3 2 Human 6.0 pKi = 6 Binding
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 578 8 3 7 5.0 CC(C)(c1ccc(Cl)cc1)[C@H](NC(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)C(=O)O 10.1016/j.bmcl.2009.09.064
CHEMBL570761 204408 0 None 3 2 Human 6.0 pKi = 6 Binding
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 578 8 3 7 5.0 CC(C)(c1ccc(Cl)cc1)[C@H](NC(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)C(=O)O 10.1016/j.bmcl.2009.09.064
45486995 204580 0 None 1 2 Human 6.0 pKi = 6 Binding
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 486 8 2 6 4.5 O=C(NCCCc1ccccc1)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.064
CHEMBL572046 204580 0 None 1 2 Human 6.0 pKi = 6 Binding
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 486 8 2 6 4.5 O=C(NCCCc1ccccc1)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.064
53465843 76185 0 None -1 2 Human 6.0 pKi = 6 Binding
Displacement of [125I]BH-(Thr,-Nle)-CCK-9 from human CCK2 receptor expressed in COS-7 cells after 60 mins by gamma countingDisplacement of [125I]BH-(Thr,-Nle)-CCK-9 from human CCK2 receptor expressed in COS-7 cells after 60 mins by gamma counting
ChEMBL 441 8 4 3 4.2 O=C(Nc1ccccc1C(=O)N[C@@H](CCc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 10.1021/jm200438b
CHEMBL1933103 76185 0 None -1 2 Human 6.0 pKi = 6 Binding
Displacement of [125I]BH-(Thr,-Nle)-CCK-9 from human CCK2 receptor expressed in COS-7 cells after 60 mins by gamma countingDisplacement of [125I]BH-(Thr,-Nle)-CCK-9 from human CCK2 receptor expressed in COS-7 cells after 60 mins by gamma counting
ChEMBL 441 8 4 3 4.2 O=C(Nc1ccccc1C(=O)N[C@@H](CCc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 10.1021/jm200438b
53465844 76186 0 None -131 2 Human 6.0 pKi = 6 Binding
Displacement of [125I]BH-(Thr,-Nle)-CCK-9 from human CCK2 receptor expressed in COS-7 cells after 60 mins by gamma countingDisplacement of [125I]BH-(Thr,-Nle)-CCK-9 from human CCK2 receptor expressed in COS-7 cells after 60 mins by gamma counting
ChEMBL 441 8 4 3 4.2 O=C(Nc1ccccc1C(=O)N[C@H](CCc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 10.1021/jm200438b
CHEMBL1933104 76186 0 None -131 2 Human 6.0 pKi = 6 Binding
Displacement of [125I]BH-(Thr,-Nle)-CCK-9 from human CCK2 receptor expressed in COS-7 cells after 60 mins by gamma countingDisplacement of [125I]BH-(Thr,-Nle)-CCK-9 from human CCK2 receptor expressed in COS-7 cells after 60 mins by gamma counting
ChEMBL 441 8 4 3 4.2 O=C(Nc1ccccc1C(=O)N[C@H](CCc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 10.1021/jm200438b
11248998 166241 0 None - 1 Human 6.0 pKi = 6 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 497 6 1 4 4.4 O=C(CN1C(=O)N(CC(=O)N2CCCC2)c2ccccc2N(c2ccccc2)C1=O)Nc1ccccc1 10.1016/j.bmc.2007.12.047
CHEMBL410138 166241 0 None - 1 Human 6.0 pKi = 6 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 497 6 1 4 4.4 O=C(CN1C(=O)N(CC(=O)N2CCCC2)c2ccccc2N(c2ccccc2)C1=O)Nc1ccccc1 10.1016/j.bmc.2007.12.047
16090795 148202 0 None - 1 Human 6.0 pKi = 6 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 484 4 1 6 4.3 O=C(c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCc2ccccc2C1 10.1021/jm060590x
CHEMBL384109 148202 0 None - 1 Human 6.0 pKi = 6 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 484 4 1 6 4.3 O=C(c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCc2ccccc2C1 10.1021/jm060590x
11362153 148481 0 None - 1 Human 6.0 pKi = 6 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 420 4 1 6 3.3 O=C(c1ccc(F)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
CHEMBL385636 148481 0 None - 1 Human 6.0 pKi = 6 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 420 4 1 6 3.3 O=C(c1ccc(F)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
11430523 167112 0 None - 1 Human 6.0 pKi = 6 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 436 4 1 6 3.8 O=C(c1c(Cl)cccc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
CHEMBL411069 167112 0 None - 1 Human 6.0 pKi = 6 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 436 4 1 6 3.8 O=C(c1c(Cl)cccc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
11555110 18738 0 None 5 2 Mouse 6.0 pKi = 6 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 500 7 5 4 5.7 O=C(O)c1cc(NC(=O)c2[nH]c(-c3ccc4[nH]ccc4c3)nc2CC2CCCCCC2)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL1182962 18738 0 None 5 2 Mouse 6.0 pKi = 6 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 500 7 5 4 5.7 O=C(O)c1cc(NC(=O)c2[nH]c(-c3ccc4[nH]ccc4c3)nc2CC2CCCCCC2)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL2067954 18738 0 None 5 2 Mouse 6.0 pKi = 6 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 500 7 5 4 5.7 O=C(O)c1cc(NC(=O)c2[nH]c(-c3ccc4[nH]ccc4c3)nc2CC2CCCCCC2)cc(C(=O)O)c1 10.1021/jm049069y
11554414 19052 0 None 7 2 Mouse 6.0 pKi = 6 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 461 7 4 4 5.2 O=C(O)c1cc(NC(=O)c2[nH]c(-c3ccccc3)nc2CC2CCCCCC2)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL1184820 19052 0 None 7 2 Mouse 6.0 pKi = 6 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 461 7 4 4 5.2 O=C(O)c1cc(NC(=O)c2[nH]c(-c3ccccc3)nc2CC2CCCCCC2)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL2067965 19052 0 None 7 2 Mouse 6.0 pKi = 6 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 461 7 4 4 5.2 O=C(O)c1cc(NC(=O)c2[nH]c(-c3ccccc3)nc2CC2CCCCCC2)cc(C(=O)O)c1 10.1021/jm049069y
44346947 22069 0 None -1 2 Mouse 5.0 pKi = 5 Binding
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 389 4 2 2 4.3 O=C(O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC1CCCCC1 10.1021/jm00048a001
CHEMBL121342 22069 0 None -1 2 Mouse 5.0 pKi = 5 Binding
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 389 4 2 2 4.3 O=C(O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC1CCCCC1 10.1021/jm00048a001
CHEMBL2112488 216018 0 None - 1 Human 4.0 pKi = 4 Binding
Apparent affinity to inhibit binding of [3H]pCCK-8 to Cholecystokinin type B receptor of guinea pig brain membranesApparent affinity to inhibit binding of [3H]pCCK-8 to Cholecystokinin type B receptor of guinea pig brain membranes
ChEMBL None None None CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN)C(=O)N[C@@H](CC(=O)O)C(N)=O 10.1021/jm00174a016
11758573 117119 0 None - 1 Mouse 7.0 pKi = 7.0 Binding
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 619 7 2 5 4.9 CC(=O)N1[C@H](C(=O)NCC(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2Cl)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
CHEMBL324032 117119 0 None - 1 Mouse 7.0 pKi = 7.0 Binding
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 619 7 2 5 4.9 CC(=O)N1[C@H](C(=O)NCC(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2Cl)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
10532660 120055 0 None - 1 Human 5.0 pKi = 5.0 Binding
Compound was tested for binding affinity against Cholecystokinin type B receptor on guinea pig cortex in experiment 1Compound was tested for binding affinity against Cholecystokinin type B receptor on guinea pig cortex in experiment 1
ChEMBL 690 19 7 7 1.0 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)/C=C\C(=O)O 10.1021/jm0000416
CHEMBL331495 120055 0 None - 1 Human 5.0 pKi = 5.0 Binding
Compound was tested for binding affinity against Cholecystokinin type B receptor on guinea pig cortex in experiment 1Compound was tested for binding affinity against Cholecystokinin type B receptor on guinea pig cortex in experiment 1
ChEMBL 690 19 7 7 1.0 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)/C=C\C(=O)O 10.1021/jm0000416
10676550 126140 0 None 12 2 Mouse 7.0 pKi = 7.0 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 751 11 5 5 6.6 O=C(O)c1ccc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc1C(=O)O 10.1021/jm00021a019
CHEMBL344396 126140 0 None 12 2 Mouse 7.0 pKi = 7.0 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 751 11 5 5 6.6 O=C(O)c1ccc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc1C(=O)O 10.1021/jm00021a019
71452773 86362 0 None - 1 Rat 6.0 pKi = 6.0 Binding
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 667 8 3 5 6.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1CC[C@@H](Oc2ccc(Cl)cc2Cl)C[C@@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
CHEMBL2114379 86362 0 None - 1 Rat 6.0 pKi = 6.0 Binding
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 667 8 3 5 6.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1CC[C@@H](Oc2ccc(Cl)cc2Cl)C[C@@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
44357011 123348 0 None -1 2 Mouse 5.0 pKi = 5.0 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 779 11 3 7 6.8 COC(=O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)OC)c1 10.1021/jm00021a019
CHEMBL336453 123348 0 None -1 2 Mouse 5.0 pKi = 5.0 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 779 11 3 7 6.8 COC(=O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)OC)c1 10.1021/jm00021a019
1647 8095 45 None -11 9 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]DAMGO from CCK2R-MOPR coexpressed in CHO cellsDisplacement of [3H]DAMGO from CCK2R-MOPR coexpressed in CHO cells
ChEMBL None None None None 10.1021/jm800174p
5462471 8095 45 None -11 9 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]DAMGO from CCK2R-MOPR coexpressed in CHO cellsDisplacement of [3H]DAMGO from CCK2R-MOPR coexpressed in CHO cells
ChEMBL None None None None 10.1021/jm800174p
CHEMBL113995 8095 45 None -11 9 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]DAMGO from CCK2R-MOPR coexpressed in CHO cellsDisplacement of [3H]DAMGO from CCK2R-MOPR coexpressed in CHO cells
ChEMBL None None None None 10.1021/jm800174p
CHEMBL38874 8095 45 None -11 9 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]DAMGO from CCK2R-MOPR coexpressed in CHO cellsDisplacement of [3H]DAMGO from CCK2R-MOPR coexpressed in CHO cells
ChEMBL None None None None 10.1021/jm800174p
CHEMBL353862 218507 0 None -1 3 Rat 8.0 pKi = 8.0 Binding
Tested for the inhibition of [3H]pCCK-8 binding to Merk CCK-B antagonist L365,260 receptor in rat brain membranesTested for the inhibition of [3H]pCCK-8 binding to Merk CCK-B antagonist L365,260 receptor in rat brain membranes
ChEMBL None None None CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)c1ccccc1 10.1016/S0960-894X(00)80678-2
10768308 21667 0 None 19 2 Human 7.9 pKi = 7.9 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 520 4 2 3 5.7 O=C(Nc1ccccc1)NC1C(=O)N(c2ccccc2)c2ccccc2N(C2[C@H]3C[C@@H]4C[C@@H](C[C@H]2C4)C3)C1=O 10.1021/jm990967h
CHEMBL120793 21667 0 None 19 2 Human 7.9 pKi = 7.9 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 520 4 2 3 5.7 O=C(Nc1ccccc1)NC1C(=O)N(c2ccccc2)c2ccccc2N(C2[C@H]3C[C@@H]4C[C@@H](C[C@H]2C4)C3)C1=O 10.1021/jm990967h
11571140 78476 0 None -2 3 Mouse 7.9 pKi = 7.9 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 489 7 3 3 6.9 O=C(O)c1cccc(NC(=O)c2[nH]c(C3CCCCCC3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
CHEMBL196517 78476 0 None -2 3 Mouse 7.9 pKi = 7.9 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 489 7 3 3 6.9 O=C(O)c1cccc(NC(=O)c2[nH]c(C3CCCCCC3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
CHEMBL120528 215382 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CC(=O)O 10.1021/jm0000416
CHEMBL1172253 215364 0 None -851 4 Human 7.0 pKi = 7.0 Binding
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2010.05.078
CHEMBL408083 219477 0 None -3 4 Human 6.0 pKi = 6.0 Binding
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](CCCC)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
16100406 89999 0 None -281 4 Human 6.0 pKi = 6.0 Binding
Displacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1132 28 13 13 1.7 CCCC[C@@H](NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1cc2ccccc2[nH]1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061268p
CHEMBL218600 89999 0 None -281 4 Human 6.0 pKi = 6.0 Binding
Displacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1132 28 13 13 1.7 CCCC[C@@H](NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1cc2ccccc2[nH]1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061268p
11512219 147415 0 None - 1 Mouse 5.0 pKi = 5.0 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 468 7 3 3 6.8 CNc1cccc(NC(=O)c2[nH]c(-c3ccccc3C)nc2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
CHEMBL381452 147415 0 None - 1 Mouse 5.0 pKi = 5.0 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 468 7 3 3 6.8 CNc1cccc(NC(=O)c2[nH]c(-c3ccccc3C)nc2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
CHEMBL3350665 218261 0 None 3 2 Human 7.0 pKi = 7.0 Binding
Apparent affinity to inhibit binding of [3H]pCCK-8 to Cholecystokinin type B receptor of guinea pig brain membranesApparent affinity to inhibit binding of [3H]pCCK-8 to Cholecystokinin type B receptor of guinea pig brain membranes
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00174a016
10459641 119015 0 None 26 2 Human 6.9 pKi = 6.9 Binding
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 529 9 3 4 5.4 COc1ccc(CCNC(=O)C(C)(Cc2c[nH]c3ccccc23)NC(=O)OC2[C@H]3C[C@@H]4C[C@@H](C[C@H]2C4)C3)cc1 10.1021/jm00072a005
CHEMBL329088 119015 0 None 26 2 Human 6.9 pKi = 6.9 Binding
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 529 9 3 4 5.4 COc1ccc(CCNC(=O)C(C)(Cc2c[nH]c3ccccc23)NC(=O)OC2[C@H]3C[C@@H]4C[C@@H](C[C@H]2C4)C3)cc1 10.1021/jm00072a005
44344934 21190 0 None - 1 Mouse 6.9 pKi = 6.9 Binding
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 615 8 2 6 4.2 COc1ccc2c(c1)C(=O)CC(C(=O)NCC(=O)O)N(C(C)=O)C(CC13CC4CC(CC(C4)C1)C3)C(=O)N2Cc1ccccc1 10.1021/jm000960w
CHEMBL120043 21190 0 None - 1 Mouse 6.9 pKi = 6.9 Binding
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 615 8 2 6 4.2 COc1ccc2c(c1)C(=O)CC(C(=O)NCC(=O)O)N(C(C)=O)C(CC13CC4CC(CC(C4)C1)C3)C(=O)N2Cc1ccccc1 10.1021/jm000960w
5311201 214174 35 None -234 6 Rat 7.9 pKi = 7.9 Binding
Affinity of compound on binding of [3H]pCCK-8 to the cholecystokinin type B receptor in rat brain membraneAffinity of compound on binding of [3H]pCCK-8 to the cholecystokinin type B receptor in rat brain membrane
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00053a022
CHEMBL9387 214174 35 None -234 6 Rat 7.9 pKi = 7.9 Binding
Affinity of compound on binding of [3H]pCCK-8 to the cholecystokinin type B receptor in rat brain membraneAffinity of compound on binding of [3H]pCCK-8 to the cholecystokinin type B receptor in rat brain membrane
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00053a022
11527738 82764 0 None -12 4 Dog 7.9 pKi = 7.9 Binding
Binding affinity to canine CCK2 receptorBinding affinity to canine CCK2 receptor
ChEMBL 518 7 2 5 5.2 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
CHEMBL205455 82764 0 None -12 4 Dog 7.9 pKi = 7.9 Binding
Binding affinity to canine CCK2 receptorBinding affinity to canine CCK2 receptor
ChEMBL 518 7 2 5 5.2 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
9985866 122256 0 None - 1 Mouse 7.9 pKi = 7.9 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 590 13 5 5 4.5 C[C@@H]1CCCC[C@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CNC(=O)CCC(=O)O)Cc1ccccc1 10.1021/jm00087a011
CHEMBL3351025 122256 0 None - 1 Mouse 7.9 pKi = 7.9 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 590 13 5 5 4.5 C[C@@H]1CCCC[C@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CNC(=O)CCC(=O)O)Cc1ccccc1 10.1021/jm00087a011
44357058 171637 0 None 173 2 Mouse 7.9 pKi = 7.9 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 785 11 5 5 7.3 O=C(O)c1cc(NC(=O)[C@@H](Cc2ccccc2Cl)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm00021a019
CHEMBL421921 171637 0 None 173 2 Mouse 7.9 pKi = 7.9 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 785 11 5 5 7.3 O=C(O)c1cc(NC(=O)[C@@H](Cc2ccccc2Cl)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm00021a019
44329798 114326 0 None 1 5 Human 7.9 pKi = 7.9 Binding
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 610 10 2 4 6.5 CC(Cc1c[nH]c2ccccc12)(C(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccc(Cl)cc1Cl)CC(=O)O 10.1021/jm00072a005
CHEMBL318852 114326 0 None 1 5 Human 7.9 pKi = 7.9 Binding
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 610 10 2 4 6.5 CC(Cc1c[nH]c2ccccc12)(C(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccc(Cl)cc1Cl)CC(=O)O 10.1021/jm00072a005
10370499 43726 0 None - 1 Mouse 7.9 pKi = 7.9 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 557 10 4 4 5.2 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CC(=O)O)Cc1ccccc1 10.1021/jm00087a011
CHEMBL145133 43726 0 None - 1 Mouse 7.9 pKi = 7.9 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 557 10 4 4 5.2 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CC(=O)O)Cc1ccccc1 10.1021/jm00087a011
45487002 204368 0 None 10 2 Human 7.9 pKi = 7.9 Binding
Displacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation counting
ChEMBL 672 8 3 7 5.1 O=C(N[C@@H](Cc1ccc(Cl)c(Br)c1)C(=O)O)c1ccc(Br)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.065
CHEMBL570520 204368 0 None 10 2 Human 7.9 pKi = 7.9 Binding
Displacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation counting
ChEMBL 672 8 3 7 5.1 O=C(N[C@@H](Cc1ccc(Cl)c(Br)c1)C(=O)O)c1ccc(Br)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.065
11802624 108813 0 None 64 2 Mouse 7.9 pKi = 7.9 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 673 11 5 5 6.2 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3ccccc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL2067966 108813 0 None 64 2 Mouse 7.9 pKi = 7.9 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 673 11 5 5 6.2 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3ccccc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL301810 108813 0 None 64 2 Mouse 7.9 pKi = 7.9 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 673 11 5 5 6.2 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3ccccc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm049069y
44328951 171376 0 None 3 2 Human 7.9 pKi = 7.9 Binding
Tested for its selectivity against human Cholecystokinin type B receptor isolated from a human temporal cortex cDNA library and stably transfected into a HeLa cell line. (n=1)Tested for its selectivity against human Cholecystokinin type B receptor isolated from a human temporal cortex cDNA library and stably transfected into a HeLa cell line. (n=1)
ChEMBL 533 5 2 4 3.8 O=C(Nc1ccc(F)cc1)NC1C(=O)N(CC(=O)N2CCCC2)c2ccccc2N(c2ccccc2F)C1=O 10.1016/S0960-894X(96)00613-0
CHEMBL421575 171376 0 None 3 2 Human 7.9 pKi = 7.9 Binding
Tested for its selectivity against human Cholecystokinin type B receptor isolated from a human temporal cortex cDNA library and stably transfected into a HeLa cell line. (n=1)Tested for its selectivity against human Cholecystokinin type B receptor isolated from a human temporal cortex cDNA library and stably transfected into a HeLa cell line. (n=1)
ChEMBL 533 5 2 4 3.8 O=C(Nc1ccc(F)cc1)NC1C(=O)N(CC(=O)N2CCCC2)c2ccccc2N(c2ccccc2F)C1=O 10.1016/S0960-894X(96)00613-0
CHEMBL1172252 215363 0 None -173 4 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2010.05.078
11542079 78497 0 None -2 3 Mouse 6.9 pKi = 6.9 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 483 7 3 3 6.5 Cc1ccccc1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
CHEMBL196580 78497 0 None -2 3 Mouse 6.9 pKi = 6.9 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 483 7 3 3 6.5 Cc1ccccc1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
44344933 175220 0 None - 1 Mouse 6.9 pKi = 6.9 Binding
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 599 7 2 5 4.5 CC(=O)N1C(C(=O)NCC(=O)O)CC(=O)c2cc(C)ccc2N(Cc2ccccc2)C(=O)C1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
CHEMBL434988 175220 0 None - 1 Mouse 6.9 pKi = 6.9 Binding
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 599 7 2 5 4.5 CC(=O)N1C(C(=O)NCC(=O)O)CC(=O)c2cc(C)ccc2N(Cc2ccccc2)C(=O)C1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
16731712 92214 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 434 5 2 4 4.2 CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL226570 92214 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 434 5 2 4 4.2 CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
44351414 123654 0 None - 1 Human 6.9 pKi = 6.9 Binding
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 634 9 3 6 5.6 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(Cl)cc2)C[C@@H]1CC(=O)O 10.1021/jm970439a
CHEMBL338252 123654 0 None - 1 Human 6.9 pKi = 6.9 Binding
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 634 9 3 6 5.6 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(Cl)cc2)C[C@@H]1CC(=O)O 10.1021/jm970439a
90663557 113474 0 None -6165 2 Rat 6.9 pKi = 6.9 Binding
Binding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligand
ChEMBL 1152 31 11 13 2.0 CCCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)NC(=O)c1ccccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm990252e
CHEMBL3143672 113474 0 None -6165 2 Rat 6.9 pKi = 6.9 Binding
Binding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligand
ChEMBL 1152 31 11 13 2.0 CCCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)NC(=O)c1ccccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm990252e
118719252 122248 0 None - 1 Mouse 6.9 pKi = 6.9 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 501 8 3 3 5.8 CC(Cc1c[nH]c2ccccc12)(NC(=O)O[C@H]1CC2CCC1(C)C2(C)C)C(=O)NCCc1ccccc1 10.1021/jm00087a011
CHEMBL3351016 122248 0 None - 1 Mouse 6.9 pKi = 6.9 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 501 8 3 3 5.8 CC(Cc1c[nH]c2ccccc12)(NC(=O)O[C@H]1CC2CCC1(C)C2(C)C)C(=O)NCCc1ccccc1 10.1021/jm00087a011
11362975 88331 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 452 4 1 6 4.3 O=C(c1cc2ccccc2cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
CHEMBL216134 88331 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 452 4 1 6 4.3 O=C(c1cc2ccccc2cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
16090651 148728 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 482 4 1 7 2.7 O=C(c1ccc(Br)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCOCC1 10.1021/jm060590x
CHEMBL387194 148728 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 482 4 1 7 2.7 O=C(c1ccc(Br)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCOCC1 10.1021/jm060590x
11178846 175744 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 468 5 1 7 4.4 O=C(c1ccc(-c2ccco2)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
CHEMBL438984 175744 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 468 5 1 7 4.4 O=C(c1ccc(-c2ccco2)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
9870515 19033 0 None 63 2 Mouse 6.9 pKi = 6.9 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 498 7 4 3 6.1 O=C(O)c1cc(NC(=O)c2cc(-c3ccccc3)[nH]c2CC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL1184696 19033 0 None 63 2 Mouse 6.9 pKi = 6.9 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 498 7 4 3 6.1 O=C(O)c1cc(NC(=O)c2cc(-c3ccccc3)[nH]c2CC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL2067955 19033 0 None 63 2 Mouse 6.9 pKi = 6.9 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 498 7 4 3 6.1 O=C(O)c1cc(NC(=O)c2cc(-c3ccccc3)[nH]c2CC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm049069y
46235271 80423 2 None -2 2 Human 5.9 pKi = 5.9 Binding
Displacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 649 7 1 6 6.7 Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 10.1021/acs.jmedchem.5b01110
CHEMBL2017835 80423 2 None -2 2 Human 5.9 pKi = 5.9 Binding
Displacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 649 7 1 6 6.7 Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 10.1021/acs.jmedchem.5b01110
45486971 204131 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 660 9 3 7 6.5 O=C(N[C@H](C(=O)O)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.064
CHEMBL569018 204131 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 660 9 3 7 6.5 O=C(N[C@H](C(=O)O)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.064
45486974 204469 0 None -50 2 Human 5.9 pKi = 5.9 Binding
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 580 7 3 7 4.8 C[C@@H](NC(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)[C@@H](O)c1cccc(Br)c1 10.1016/j.bmcl.2009.09.064
CHEMBL571206 204469 0 None -50 2 Human 5.9 pKi = 5.9 Binding
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 580 7 3 7 4.8 C[C@@H](NC(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)[C@@H](O)c1cccc(Br)c1 10.1016/j.bmcl.2009.09.064
44417439 88430 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 509 7 2 7 3.4 O=C(C1=C(NS(=O)(=O)c2cccc3nsnc23)CC(NCc2ccccc2)C=C1)N1CCCCC1 10.1021/jm060590x
CHEMBL216360 88430 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 509 7 2 7 3.4 O=C(C1=C(NS(=O)(=O)c2cccc3nsnc23)CC(NCc2ccccc2)C=C1)N1CCCCC1 10.1021/jm060590x
16090796 148258 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 464 4 1 6 4.3 CC1CC(C)CN(C(=O)c2ccc(Cl)cc2NS(=O)(=O)c2cccc3nsnc23)C1 10.1021/jm060590x
CHEMBL384387 148258 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 464 4 1 6 4.3 CC1CC(C)CN(C(=O)c2ccc(Cl)cc2NS(=O)(=O)c2cccc3nsnc23)C1 10.1021/jm060590x
11431264 148495 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 466 5 2 7 3.0 O=C(c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCC(CO)CC1 10.1021/jm060590x
CHEMBL385734 148495 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 466 5 2 7 3.0 O=C(c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCC(CO)CC1 10.1021/jm060590x
9890720 175249 0 None 2 2 Mouse 5.9 pKi = 5.9 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 466 6 3 2 7.3 O=C(O)c1cccc(NC(=O)c2cc(-c3ccc4ccccc4c3)[nH]c2CC2CCCCCC2)c1 10.1021/jm049069y
CHEMBL2067971 175249 0 None 2 2 Mouse 5.9 pKi = 5.9 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 466 6 3 2 7.3 O=C(O)c1cccc(NC(=O)c2cc(-c3ccc4ccccc4c3)[nH]c2CC2CCCCCC2)c1 10.1021/jm049069y
CHEMBL435127 175249 0 None 2 2 Mouse 5.9 pKi = 5.9 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 466 6 3 2 7.3 O=C(O)c1cccc(NC(=O)c2cc(-c3ccc4ccccc4c3)[nH]c2CC2CCCCCC2)c1 10.1021/jm049069y
10580492 21308 0 None - 1 Human 5.9 pKi = 5.9 Binding
Compound was tested for binding affinity against Cholecystokinin type B receptor on guinea pig cortex in experiment 2Compound was tested for binding affinity against Cholecystokinin type B receptor on guinea pig cortex in experiment 2
ChEMBL 690 19 7 7 1.0 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)/C=C/C(=O)O 10.1021/jm0000416
CHEMBL120257 21308 0 None - 1 Human 5.9 pKi = 5.9 Binding
Compound was tested for binding affinity against Cholecystokinin type B receptor on guinea pig cortex in experiment 2Compound was tested for binding affinity against Cholecystokinin type B receptor on guinea pig cortex in experiment 2
ChEMBL 690 19 7 7 1.0 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)/C=C/C(=O)O 10.1021/jm0000416
10628696 30120 0 None - 1 Mouse 5.9 pKi = 5.9 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 723 11 5 5 6.2 O=C(NCC12CC3CC(CC(C3)C1)C2)C1C2c3ccccc3C(c3ccccc32)C1C(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1cc(CO)cc(CO)c1 10.1021/jm00021a019
CHEMBL133249 30120 0 None - 1 Mouse 5.9 pKi = 5.9 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 723 11 5 5 6.2 O=C(NCC12CC3CC(CC(C3)C1)C2)C1C2c3ccccc3C(c3ccccc32)C1C(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1cc(CO)cc(CO)c1 10.1021/jm00021a019
44356430 122009 0 None 70 2 Mouse 7.9 pKi = 7.9 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 769 11 5 5 6.7 O=C(O)c1cc(NC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm00021a019
CHEMBL334714 122009 0 None 70 2 Mouse 7.9 pKi = 7.9 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 769 11 5 5 6.7 O=C(O)c1cc(NC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm00021a019
11712880 145701 0 None 2 3 Human 7.9 pKi = 7.9 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 490 6 2 5 5.2 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
CHEMBL378388 145701 0 None 2 3 Human 7.9 pKi = 7.9 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 490 6 2 5 5.2 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
11555166 146608 0 None 2 3 Human 7.9 pKi = 7.9 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 502 7 2 5 5.5 CNc1cccc(NC(=O)C[C@H]2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
CHEMBL379902 146608 0 None 2 3 Human 7.9 pKi = 7.9 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 502 7 2 5 5.5 CNc1cccc(NC(=O)C[C@H]2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
10817243 120294 0 None 22 2 Human 7.9 pKi = 7.9 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 591 7 2 4 6.6 CN(C)c1cccc(NC(=O)NC2C(=O)N(CCC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 10.1021/jm990967h
CHEMBL332128 120294 0 None 22 2 Human 7.9 pKi = 7.9 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 591 7 2 4 6.6 CN(C)c1cccc(NC(=O)NC2C(=O)N(CCC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 10.1021/jm990967h
11802624 108813 0 None 64 2 Mouse 7.9 pKi = 7.9 Binding
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 673 11 5 5 6.2 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3ccccc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm9508907
CHEMBL2067966 108813 0 None 64 2 Mouse 7.9 pKi = 7.9 Binding
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 673 11 5 5 6.2 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3ccccc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm9508907
CHEMBL301810 108813 0 None 64 2 Mouse 7.9 pKi = 7.9 Binding
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 673 11 5 5 6.2 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3ccccc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm9508907
9832467 151071 0 None -15 5 Mouse 7.9 pKi = 7.9 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 477 7 3 4 5.9 O=C(O)c1cccc(NC(=O)c2nc(C3CCCCC3)[nH]c2COC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
CHEMBL390519 151071 0 None -15 5 Mouse 7.9 pKi = 7.9 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 477 7 3 4 5.9 O=C(O)c1cccc(NC(=O)c2nc(C3CCCCC3)[nH]c2COC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
10580234 105810 0 None 251 2 Mouse 7.9 pKi = 7.9 Binding
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 662 11 6 5 5.5 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3[nH]ccc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm9508907
CHEMBL280248 105810 0 None 251 2 Mouse 7.9 pKi = 7.9 Binding
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 662 11 6 5 5.5 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3[nH]ccc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm9508907
10257865 215217 4 None -2 5 Mouse 7.9 pKi = 7.9 Binding
Tested for binding affinity towards cholecystokinin type B receptor in mouse brain by displacement of [3H]pBC264 radioligandTested for binding affinity towards cholecystokinin type B receptor in mouse brain by displacement of [3H]pBC264 radioligand
ChEMBL 591 10 3 4 5.8 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccc(Cl)cc1)CC(=O)O 10.1021/jm00072a005
CHEMBL99939 215217 4 None -2 5 Mouse 7.9 pKi = 7.9 Binding
Tested for binding affinity towards cholecystokinin type B receptor in mouse brain by displacement of [3H]pBC264 radioligandTested for binding affinity towards cholecystokinin type B receptor in mouse brain by displacement of [3H]pBC264 radioligand
ChEMBL 591 10 3 4 5.8 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccc(Cl)cc1)CC(=O)O 10.1021/jm00072a005
11613212 78876 0 None -1 3 Mouse 7.9 pKi = 7.9 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 513 7 3 4 6.4 Cc1cc(C)c(-c2nc(C(=O)Nc3cccc(C(=O)O)c3)c(COC34CC5CC(CC(C5)C3)C4)[nH]2)c(C)c1 10.1021/jm0490686
CHEMBL197780 78876 0 None -1 3 Mouse 7.9 pKi = 7.9 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 513 7 3 4 6.4 Cc1cc(C)c(-c2nc(C(=O)Nc3cccc(C(=O)O)c3)c(COC34CC5CC(CC(C5)C3)C4)[nH]2)c(C)c1 10.1021/jm0490686
44408525 176207 0 None -56 3 Human 5.9 pKi = 5.9 Binding
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1075 30 12 14 1.5 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@@H](Cc1cn(C(C)=O)c2ccccc12)C(=O)O 10.1021/jm050851n
CHEMBL442483 176207 0 None -56 3 Human 5.9 pKi = 5.9 Binding
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1075 30 12 14 1.5 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@@H](Cc1cn(C(C)=O)c2ccccc12)C(=O)O 10.1021/jm050851n
10430432 25597 0 None -25703 5 Human 4.9 pKi = 4.9 Binding
Binding affinity against Cholecystokinin type B receptor using [3H](MeNLE28,31)-CCK-8 as radioligand in guinea pig cerebral cortex.Binding affinity against Cholecystokinin type B receptor using [3H](MeNLE28,31)-CCK-8 as radioligand in guinea pig cerebral cortex.
ChEMBL 389 5 1 4 4.2 CN1c2ccccc2C(c2ccccc2)=NCC1CCNC(=O)c1cccs1 10.1021/jm950423p
CHEMBL127969 25597 0 None -25703 5 Human 4.9 pKi = 4.9 Binding
Binding affinity against Cholecystokinin type B receptor using [3H](MeNLE28,31)-CCK-8 as radioligand in guinea pig cerebral cortex.Binding affinity against Cholecystokinin type B receptor using [3H](MeNLE28,31)-CCK-8 as radioligand in guinea pig cerebral cortex.
ChEMBL 389 5 1 4 4.2 CN1c2ccccc2C(c2ccccc2)=NCC1CCNC(=O)c1cccs1 10.1021/jm950423p
9890720 175249 0 None 2 2 Mouse 5.9 pKi = 5.9 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 466 6 3 2 7.3 O=C(O)c1cccc(NC(=O)c2cc(-c3ccc4ccccc4c3)[nH]c2CC2CCCCCC2)c1 10.1021/jm0490686
CHEMBL2067971 175249 0 None 2 2 Mouse 5.9 pKi = 5.9 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 466 6 3 2 7.3 O=C(O)c1cccc(NC(=O)c2cc(-c3ccc4ccccc4c3)[nH]c2CC2CCCCCC2)c1 10.1021/jm0490686
CHEMBL435127 175249 0 None 2 2 Mouse 5.9 pKi = 5.9 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 466 6 3 2 7.3 O=C(O)c1cccc(NC(=O)c2cc(-c3ccc4ccccc4c3)[nH]c2CC2CCCCCC2)c1 10.1021/jm0490686
10099504 214992 0 None 14 2 Human 6.9 pKi = 6.9 Binding
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 568 10 2 4 5.8 CC(Cc1cccc2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccc1)CC(=O)O 10.1021/jm00072a005
CHEMBL98516 214992 0 None 14 2 Human 6.9 pKi = 6.9 Binding
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 568 10 2 4 5.8 CC(Cc1cccc2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccc1)CC(=O)O 10.1021/jm00072a005
101629632 122244 0 None - 1 Mouse 6.9 pKi = 6.9 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 461 8 3 3 5.1 C[C@@H]1CCCC[C@H]1OC(=O)NC(C)(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 10.1021/jm00087a011
CHEMBL3351012 122244 0 None - 1 Mouse 6.9 pKi = 6.9 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 461 8 3 3 5.1 C[C@@H]1CCCC[C@H]1OC(=O)NC(C)(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 10.1021/jm00087a011
10794888 172031 0 None 15 2 Mouse 6.9 pKi = 6.9 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 707 10 4 4 6.9 O=C(O)c1ccc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc1 10.1021/jm00021a019
CHEMBL422981 172031 0 None 15 2 Mouse 6.9 pKi = 6.9 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 707 10 4 4 6.9 O=C(O)c1ccc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc1 10.1021/jm00021a019
118719250 122246 0 None - 1 Mouse 6.9 pKi = 6.9 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 543 10 4 4 4.8 O=C(O)C[C@@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1021/jm00087a011
CHEMBL3351014 122246 0 None - 1 Mouse 6.9 pKi = 6.9 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 543 10 4 4 4.8 O=C(O)C[C@@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1021/jm00087a011
10531553 123408 0 None 31 2 Mouse 6.9 pKi = 6.9 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 595 7 3 4 4.0 O=C(O)CNC(=O)[C@@H]1CCCN1C(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC12C[C@H]3C[C@@H](C1)C[C@@H](C2)C3 10.1021/jm00021a019
CHEMBL336896 123408 0 None 31 2 Mouse 6.9 pKi = 6.9 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 595 7 3 4 4.0 O=C(O)CNC(=O)[C@@H]1CCCN1C(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC12C[C@H]3C[C@@H](C1)C[C@@H](C2)C3 10.1021/jm00021a019
10077166 106710 0 None 75 2 Rat 7.9 pKi = 7.9 Binding
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 591 10 3 4 5.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N(CCc1ccc(Cl)cc1)CC(=O)O 10.1016/s0960-894x(98)00231-5
CHEMBL286247 106710 0 None 75 2 Rat 7.9 pKi = 7.9 Binding
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 591 10 3 4 5.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N(CCc1ccc(Cl)cc1)CC(=O)O 10.1016/s0960-894x(98)00231-5
44280157 162508 0 None 75 2 Rat 7.9 pKi = 7.9 Binding
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 667 8 3 5 6.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1CC[C@H](Oc2ccc(Cl)cc2Cl)C[C@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
CHEMBL405468 162508 0 None 75 2 Rat 7.9 pKi = 7.9 Binding
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 667 8 3 5 6.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1CC[C@H](Oc2ccc(Cl)cc2Cl)C[C@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
44351477 123625 0 None - 1 Human 7.9 pKi = 7.9 Binding
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 569 7 3 4 5.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1CC(c2ccccc2)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL338072 123625 0 None - 1 Human 7.9 pKi = 7.9 Binding
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 569 7 3 4 5.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1CC(c2ccccc2)C[C@@H]1C(=O)O 10.1021/jm970439a
44351469 123713 0 None -2 2 Rat 7.9 pKi = 7.9 Binding
Compounds were tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.Compounds were tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.
ChEMBL 603 7 3 4 6.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1CC(c2ccc(Cl)cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL338526 123713 0 None -2 2 Rat 7.9 pKi = 7.9 Binding
Compounds were tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.Compounds were tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.
ChEMBL 603 7 3 4 6.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1CC(c2ccc(Cl)cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
5311201 214174 35 None -27 6 Human 7.9 pKi = 7.9 Binding
Displacement of [125I]CCK-26-33 from CCK2R-MOPR coexpressed in CHO cellsDisplacement of [125I]CCK-26-33 from CCK2R-MOPR coexpressed in CHO cells
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm800174p
CHEMBL9387 214174 35 None -27 6 Human 7.9 pKi = 7.9 Binding
Displacement of [125I]CCK-26-33 from CCK2R-MOPR coexpressed in CHO cellsDisplacement of [125I]CCK-26-33 from CCK2R-MOPR coexpressed in CHO cells
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm800174p
CHEMBL3351055 218318 0 None 70 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL None None None CC(C)(C)OC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1cccc2ccccc12)c1ccccc1 10.1021/jm00053a022
44329798 114326 0 None -1 5 Mouse 7.9 pKi = 7.9 Binding
Tested for binding affinity towards cholecystokinin type B receptor in mouse brain by displacement of [3H]pBC264 radioligand (icv)Tested for binding affinity towards cholecystokinin type B receptor in mouse brain by displacement of [3H]pBC264 radioligand (icv)
ChEMBL 610 10 2 4 6.5 CC(Cc1c[nH]c2ccccc12)(C(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccc(Cl)cc1Cl)CC(=O)O 10.1021/jm00072a005
CHEMBL318852 114326 0 None -1 5 Mouse 7.9 pKi = 7.9 Binding
Tested for binding affinity towards cholecystokinin type B receptor in mouse brain by displacement of [3H]pBC264 radioligand (icv)Tested for binding affinity towards cholecystokinin type B receptor in mouse brain by displacement of [3H]pBC264 radioligand (icv)
ChEMBL 610 10 2 4 6.5 CC(Cc1c[nH]c2ccccc12)(C(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccc(Cl)cc1Cl)CC(=O)O 10.1021/jm00072a005
10482868 114181 0 None 2 5 Human 7.9 pKi = 7.9 Binding
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 557 10 3 4 5.2 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccc1)CC(=O)O 10.1021/jm00072a005
CHEMBL317999 114181 0 None 2 5 Human 7.9 pKi = 7.9 Binding
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 557 10 3 4 5.2 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccc1)CC(=O)O 10.1021/jm00072a005
CHEMBL353862 218507 0 None 1 3 Human 7.9 pKi = 7.9 Binding
Tested for the inhibition of [3H]pCCK-8 to Cholecystokinin type B receptor in guinea pig brainTested for the inhibition of [3H]pCCK-8 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL None None None CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)c1ccccc1 10.1016/S0960-894X(00)80678-2
44580901 176246 0 None -3 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]DAMGO from CCK2R-MOPR coexpressed in CHO cellsDisplacement of [3H]DAMGO from CCK2R-MOPR coexpressed in CHO cells
ChEMBL 843 12 6 11 2.8 CN1C(=O)[C@H](NC(=O)Nc2cccc(OCCNC(=O)COCC(=O)N[C@H]3CC[C@@]4(O)[C@H]5Cc6cc(O)cc7c6[C@@]4(CCN5C)[C@H]3O7)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm800174p
CHEMBL442943 176246 0 None -3 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]DAMGO from CCK2R-MOPR coexpressed in CHO cellsDisplacement of [3H]DAMGO from CCK2R-MOPR coexpressed in CHO cells
ChEMBL 843 12 6 11 2.8 CN1C(=O)[C@H](NC(=O)Nc2cccc(OCCNC(=O)COCC(=O)N[C@H]3CC[C@@]4(O)[C@H]5Cc6cc(O)cc7c6[C@@]4(CCN5C)[C@H]3O7)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm800174p
9853654 29561 41 None 31 2 Human 7.8 pKi = 7.8 Binding
Inhibition of binding of [125I]-PD 142308 to CCK-B receptor was determinedInhibition of binding of [125I]-PD 142308 to CCK-B receptor was determined
ChEMBL 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/0960-894X(95)00435-V
CHEMBL1328 29561 41 None 31 2 Human 7.8 pKi = 7.8 Binding
Inhibition of binding of [125I]-PD 142308 to CCK-B receptor was determinedInhibition of binding of [125I]-PD 142308 to CCK-B receptor was determined
ChEMBL 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/0960-894X(95)00435-V
CHEMBL3351052 218315 0 None 14 2 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL None None None CN(C(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1cccc2ccccc12)C1CCCCC1)[C@@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C 10.1021/jm00053a022
CHEMBL2370437 216629 0 None 10 2 Human 5.9 pKi = 5.9 Binding
Apparent affinity to inhibit binding of [3H]pCCK-8 to Cholecystokinin type B receptor of guinea pig brain membranesApparent affinity to inhibit binding of [3H]pCCK-8 to Cholecystokinin type B receptor of guinea pig brain membranes
ChEMBL None None None CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00174a016
11571166 148092 0 None -1 2 Mouse 6.9 pKi = 6.9 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 497 7 3 3 6.8 Cc1cccc(C)c1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
CHEMBL383386 148092 0 None -1 2 Mouse 6.9 pKi = 6.9 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 497 7 3 3 6.8 Cc1cccc(C)c1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
46235271 80423 2 None -2 2 Human 5.9 pKi = 5.9 Binding
Displacement of [125I-CCK] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-CCK] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 649 7 1 6 6.7 Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 10.1021/acs.jmedchem.5b01110
CHEMBL2017835 80423 2 None -2 2 Human 5.9 pKi = 5.9 Binding
Displacement of [125I-CCK] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-CCK] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 649 7 1 6 6.7 Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 10.1021/acs.jmedchem.5b01110
73354642 96233 0 None -2 3 Rat 6.9 pKi = 6.9 Binding
Affinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cellsAffinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cells
ChEMBL 646 11 7 6 1.6 C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm9603072
CHEMBL2371225 96233 0 None -2 3 Rat 6.9 pKi = 6.9 Binding
Affinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cellsAffinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cells
ChEMBL 646 11 7 6 1.6 C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm9603072
11583614 172906 0 None - 1 Mouse 5.8 pKi = 5.8 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 469 6 3 3 6.1 Cc1ccccc1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
CHEMBL426102 172906 0 None - 1 Mouse 5.8 pKi = 5.8 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 469 6 3 3 6.1 Cc1ccccc1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
CHEMBL431676 220406 0 None - 1 Human 5.8 pKi = 5.8 Binding
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)O 10.1021/jm0000416
44387568 68981 0 None 1 3 Human 7.8 pKi = 7.8 Binding
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 660 11 7 6 2.0 C[C@@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm0000416
CHEMBL177799 68981 0 None 1 3 Human 7.8 pKi = 7.8 Binding
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 660 11 7 6 2.0 C[C@@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm0000416
5311201 214174 35 None -234 6 Rat 7.8 pKi = 7.8 Binding
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/s0960-894x(98)00231-5
CHEMBL9387 214174 35 None -234 6 Rat 7.8 pKi = 7.8 Binding
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/s0960-894x(98)00231-5
5311201 214174 35 None -234 6 Rat 7.8 pKi = 7.8 Binding
Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm970439a
CHEMBL9387 214174 35 None -234 6 Rat 7.8 pKi = 7.8 Binding
Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm970439a
CHEMBL208479 215978 0 None -5 4 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](CCCC)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm050921q
CHEMBL218763 216178 0 None -15 4 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
73347063 96229 0 None 1 3 Human 7.8 pKi = 7.8 Binding
Inhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptorInhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptor
ChEMBL 674 11 7 6 2.4 C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCCCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm9603072
CHEMBL2371221 96229 0 None 1 3 Human 7.8 pKi = 7.8 Binding
Inhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptorInhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptor
ChEMBL 674 11 7 6 2.4 C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCCCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm9603072
10327028 96230 0 None 1 3 Human 7.8 pKi = 7.8 Binding
Inhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptorInhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptor
ChEMBL 660 11 7 6 2.0 C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm9603072
CHEMBL2371222 96230 0 None 1 3 Human 7.8 pKi = 7.8 Binding
Inhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptorInhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptor
ChEMBL 660 11 7 6 2.0 C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm9603072
10480793 122203 0 None - 1 Mouse 7.8 pKi = 7.8 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 491 9 4 4 4.5 C[C@@H]1CCCC[C@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00087a011
CHEMBL3350395 122203 0 None - 1 Mouse 7.8 pKi = 7.8 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 491 9 4 4 4.5 C[C@@H]1CCCC[C@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00087a011
10747623 176260 0 None 29 2 Mouse 7.8 pKi = 7.8 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 746 12 6 5 6.1 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCCc2c[nH]c3ccccc23)cc(C(=O)O)c1 10.1021/jm00021a019
CHEMBL443028 176260 0 None 29 2 Mouse 7.8 pKi = 7.8 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 746 12 6 5 6.1 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCCc2c[nH]c3ccccc23)cc(C(=O)O)c1 10.1021/jm00021a019
11656338 82720 0 None 1 3 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 504 7 2 5 5.0 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CO)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
CHEMBL205198 82720 0 None 1 3 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 504 7 2 5 5.0 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CO)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
10603971 108392 0 None 208 2 Mouse 7.8 pKi = 7.8 Binding
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 624 11 6 5 5.2 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3cc[nH]c3cc2C(=O)NCC2CCCCCC2)cc(C(=O)O)c1 10.1021/jm9508907
CHEMBL298861 108392 0 None 208 2 Mouse 7.8 pKi = 7.8 Binding
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 624 11 6 5 5.2 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3cc[nH]c3cc2C(=O)NCC2CCCCCC2)cc(C(=O)O)c1 10.1021/jm9508907
11802426 107059 0 None 50 2 Rat 7.8 pKi = 7.8 Binding
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 653 8 3 5 6.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1C[C@H](Oc2ccc(Cl)cc2Cl)C[C@@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
CHEMBL289021 107059 0 None 50 2 Rat 7.8 pKi = 7.8 Binding
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 653 8 3 5 6.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1C[C@H](Oc2ccc(Cl)cc2Cl)C[C@@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
44351445 123712 0 None -1 2 Rat 7.8 pKi = 7.8 Binding
Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.
ChEMBL 654 8 3 6 5.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(Cl)cc2Cl)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL338525 123712 0 None -1 2 Rat 7.8 pKi = 7.8 Binding
Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.
ChEMBL 654 8 3 6 5.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(Cl)cc2Cl)C[C@@H]1C(=O)O 10.1021/jm970439a
118719253 122251 0 None - 1 Mouse 7.8 pKi = 7.8 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 531 9 4 4 5.1 CC1(C)C2CCC1(C)C(OC(=O)N[C@](C)(Cc1c[nH]c3ccccc13)C(=O)N[C@H](CO)Cc1ccccc1)C2 10.1021/jm00087a011
CHEMBL3351019 122251 0 None - 1 Mouse 7.8 pKi = 7.8 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 531 9 4 4 5.1 CC1(C)C2CCC1(C)C(OC(=O)N[C@](C)(Cc1c[nH]c3ccccc13)C(=O)N[C@H](CO)Cc1ccccc1)C2 10.1021/jm00087a011
45255234 205815 0 None 15 2 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 584 8 3 7 4.9 O=C(N[C@@H](Cc1ccc(Cl)c(Cl)c1)C(=O)O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.064
CHEMBL585914 205815 0 None 15 2 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 584 8 3 7 4.9 O=C(N[C@@H](Cc1ccc(Cl)c(Cl)c1)C(=O)O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.064
45255234 205815 0 None 15 2 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation counting
ChEMBL 584 8 3 7 4.9 O=C(N[C@@H](Cc1ccc(Cl)c(Cl)c1)C(=O)O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.065
CHEMBL585914 205815 0 None 15 2 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation counting
ChEMBL 584 8 3 7 4.9 O=C(N[C@@H](Cc1ccc(Cl)c(Cl)c1)C(=O)O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.065
11613982 147203 0 None 9 2 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 543 7 1 5 6.1 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(N3CCCC3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
CHEMBL380907 147203 0 None 9 2 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 543 7 1 5 6.1 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(N3CCCC3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
16090790 148393 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 470 4 1 6 4.4 O=C(c1cc(Cl)c(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
CHEMBL385153 148393 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 470 4 1 6 4.4 O=C(c1cc(Cl)c(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
10652140 108621 0 None 177 2 Mouse 7.8 pKi = 7.8 Binding
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 679 11 7 7 4.6 O=C(O)c1cc(NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm9508907
CHEMBL300456 108621 0 None 177 2 Mouse 7.8 pKi = 7.8 Binding
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 679 11 7 7 4.6 O=C(O)c1cc(NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm9508907
44403984 19083 0 None 125 2 Mouse 7.8 pKi = 7.8 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 677 11 5 6 5.2 CN(CC12CC3CC(CC(C3)C1)C2)C(=O)c1cc2[nH]cnc2cc1C(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1cc(C(=O)O)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL1185003 19083 0 None 125 2 Mouse 7.8 pKi = 7.8 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 677 11 5 6 5.2 CN(CC12CC3CC(CC(C3)C1)C2)C(=O)c1cc2[nH]cnc2cc1C(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1cc(C(=O)O)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL2067967 19083 0 None 125 2 Mouse 7.8 pKi = 7.8 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 677 11 5 6 5.2 CN(CC12CC3CC(CC(C3)C1)C2)C(=O)c1cc2[nH]cnc2cc1C(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1cc(C(=O)O)cc(C(=O)O)c1 10.1021/jm049069y
10819816 125519 0 None -7 2 Rat 6.8 pKi = 6.8 Binding
Binding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomesBinding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomes
ChEMBL 998 28 10 13 0.4 CSCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm970477u
CHEMBL341762 125519 0 None -7 2 Rat 6.8 pKi = 6.8 Binding
Binding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomesBinding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomes
ChEMBL 998 28 10 13 0.4 CSCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm970477u
73354497 96160 0 None -7 2 Rat 6.8 pKi = 6.8 Binding
Binding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligand
ChEMBL 998 28 10 13 0.4 CSCC[C@@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCSC)C(=O)N[C@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm990252e
CHEMBL2369817 96160 0 None -7 2 Rat 6.8 pKi = 6.8 Binding
Binding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligand
ChEMBL 998 28 10 13 0.4 CSCC[C@@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCSC)C(=O)N[C@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm990252e
CHEMBL262172 217307 0 None -691 4 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm050921q
44408526 143723 0 None -1862 4 Human 5.8 pKi = 5.8 Binding
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1148 30 11 15 3.0 CCCC[C@@H](C(=O)N[C@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)C(=O)O)N(C)C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O 10.1021/jm050851n
CHEMBL374325 143723 0 None -1862 4 Human 5.8 pKi = 5.8 Binding
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1148 30 11 15 3.0 CCCC[C@@H](C(=O)N[C@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)C(=O)O)N(C)C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O 10.1021/jm050851n
44346825 121551 0 None 77 2 Mouse 6.8 pKi = 6.8 Binding
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 623 8 3 4 4.7 C[C@@H](NC(=O)C[C@@H]1CCCN1C(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC1C2CC3CC(C2)CC1C3)C(=O)O 10.1021/jm00048a001
CHEMBL333920 121551 0 None 77 2 Mouse 6.8 pKi = 6.8 Binding
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 623 8 3 4 4.7 C[C@@H](NC(=O)C[C@@H]1CCCN1C(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC1C2CC3CC(C2)CC1C3)C(=O)O 10.1021/jm00048a001
44215880 76183 0 None -3890 2 Human 4.8 pKi = 4.8 Binding
Displacement of [125I]BH-(Thr,-Nle)-CCK-9 from human CCK2 receptor expressed in COS-7 cells after 60 mins by gamma countingDisplacement of [125I]BH-(Thr,-Nle)-CCK-9 from human CCK2 receptor expressed in COS-7 cells after 60 mins by gamma counting
ChEMBL 441 8 4 3 4.2 O=C(Nc1ccccc1C(=O)NC(CCc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 10.1021/jm200438b
CHEMBL1933100 76183 0 None -3890 2 Human 4.8 pKi = 4.8 Binding
Displacement of [125I]BH-(Thr,-Nle)-CCK-9 from human CCK2 receptor expressed in COS-7 cells after 60 mins by gamma countingDisplacement of [125I]BH-(Thr,-Nle)-CCK-9 from human CCK2 receptor expressed in COS-7 cells after 60 mins by gamma counting
ChEMBL 441 8 4 3 4.2 O=C(Nc1ccccc1C(=O)NC(CCc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 10.1021/jm200438b
44280199 106367 0 None - 1 Rat 5.8 pKi = 5.8 Binding
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 681 8 2 6 6.9 COC(=O)[C@H]1C[C@@H](Oc2ccc(Cl)cc2Cl)CCN1C(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1016/s0960-894x(98)00231-5
CHEMBL283913 106367 0 None - 1 Rat 5.8 pKi = 5.8 Binding
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 681 8 2 6 6.9 COC(=O)[C@H]1C[C@@H](Oc2ccc(Cl)cc2Cl)CCN1C(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1016/s0960-894x(98)00231-5
44347144 119843 0 None 12 2 Mouse 5.8 pKi = 5.8 Binding
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 512 6 2 4 4.0 COC(=O)CNC(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC1C2CC3CC(C2)CC1C3 10.1021/jm00048a001
CHEMBL331177 119843 0 None 12 2 Mouse 5.8 pKi = 5.8 Binding
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 512 6 2 4 4.0 COC(=O)CNC(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC1C2CC3CC(C2)CC1C3 10.1021/jm00048a001
44342477 117300 0 None - 1 Rat 5.8 pKi = 5.8 Binding
Inhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranesInhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranes
ChEMBL 588 8 3 6 3.9 COC(=O)[C@]1(Cc2ccccc2)C[C@@H]2[C@@H](NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)OC(C)(C)C)CCCN2C1=O 10.1021/jm9703247
CHEMBL325070 117300 0 None - 1 Rat 5.8 pKi = 5.8 Binding
Inhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranesInhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranes
ChEMBL 588 8 3 6 3.9 COC(=O)[C@]1(Cc2ccccc2)C[C@@H]2[C@@H](NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)OC(C)(C)C)CCCN2C1=O 10.1021/jm9703247
11556194 204338 0 None 3 2 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 598 8 3 7 5.4 C[C@H](c1ccc(Cl)c(Cl)c1)[C@H](NC(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)C(=O)O 10.1016/j.bmcl.2009.09.064
CHEMBL570297 204338 0 None 3 2 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 598 8 3 7 5.4 C[C@H](c1ccc(Cl)c(Cl)c1)[C@H](NC(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)C(=O)O 10.1016/j.bmcl.2009.09.064
45486958 204367 0 None 19 2 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 516 8 3 7 3.6 O=C(N[C@H](Cc1ccccc1)C(=O)O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.064
CHEMBL570518 204367 0 None 19 2 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 516 8 3 7 3.6 O=C(N[C@H](Cc1ccccc1)C(=O)O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.064
11420366 87114 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 486 6 1 7 4.4 O=C(c1ccc(OC2CCCC2)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
CHEMBL214277 87114 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 486 6 1 7 4.4 O=C(c1ccc(OC2CCCC2)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
16090788 87389 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 478 5 1 6 4.8 O=C(c1ccc(-c2ccccc2)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
CHEMBL215111 87389 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 478 5 1 6 4.8 O=C(c1ccc(-c2ccccc2)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
11316813 88906 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 447 5 1 8 3.0 O=C(c1ccc([N+](=O)[O-])cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
CHEMBL216707 88906 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 447 5 1 8 3.0 O=C(c1ccc([N+](=O)[O-])cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
16090685 103853 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 558 4 1 6 4.6 O=C(c1ccc(Br)cc1NS(=O)(=O)c1ccc(Br)c2nsnc12)N1CCCCC1 10.1021/jm060590x
CHEMBL267290 103853 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 558 4 1 6 4.6 O=C(c1ccc(Br)cc1NS(=O)(=O)c1ccc(Br)c2nsnc12)N1CCCCC1 10.1021/jm060590x
11293780 148409 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 446 4 1 6 2.9 C[C@@H]1COCCN1C(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nccnc12 10.1021/jm060590x
CHEMBL385285 148409 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 446 4 1 6 2.9 C[C@@H]1COCCN1C(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nccnc12 10.1021/jm060590x
11576933 19040 0 None 19 2 Mouse 6.8 pKi = 6.8 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 499 7 4 4 5.5 O=C(O)c1cc(NC(=O)c2[nH]c(-c3ccccc3)nc2CC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL1184725 19040 0 None 19 2 Mouse 6.8 pKi = 6.8 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 499 7 4 4 5.5 O=C(O)c1cc(NC(=O)c2[nH]c(-c3ccccc3)nc2CC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL2067957 19040 0 None 19 2 Mouse 6.8 pKi = 6.8 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 499 7 4 4 5.5 O=C(O)c1cc(NC(=O)c2[nH]c(-c3ccccc3)nc2CC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm049069y
19043361 11391 0 None -162 2 Human 5.8 pKi = 5.8 Binding
Binding affinity was measured by its ability to displace [3H]CCK-8S from CCK-B receptor in guinea pig brainBinding affinity was measured by its ability to displace [3H]CCK-8S from CCK-B receptor in guinea pig brain
ChEMBL 524 6 2 3 6.2 CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2cc(Cl)c(Cl)cc21 10.1016/0960-894X(95)00528-2
CHEMBL102867 11391 0 None -162 2 Human 5.8 pKi = 5.8 Binding
Binding affinity was measured by its ability to displace [3H]CCK-8S from CCK-B receptor in guinea pig brainBinding affinity was measured by its ability to displace [3H]CCK-8S from CCK-B receptor in guinea pig brain
ChEMBL 524 6 2 3 6.2 CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2cc(Cl)c(Cl)cc21 10.1016/0960-894X(95)00528-2
45486969 204249 0 None -7 2 Human 5.8 pKi = 5.8 Binding
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 598 8 3 7 5.4 C[C@H](c1ccc(Cl)c(Cl)c1)[C@@H](NC(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)C(=O)O 10.1016/j.bmcl.2009.09.064
CHEMBL569849 204249 0 None -7 2 Human 5.8 pKi = 5.8 Binding
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 598 8 3 7 5.4 C[C@H](c1ccc(Cl)c(Cl)c1)[C@@H](NC(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)C(=O)O 10.1016/j.bmcl.2009.09.064
11584582 205647 0 None -19 2 Human 5.8 pKi = 5.8 Binding
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 530 7 2 6 4.8 C[C@@H](CNC(=O)c1ccc(Br)cc1NS(=O)(=O)c1cccc2nsnc12)c1ccccc1 10.1016/j.bmcl.2009.09.064
CHEMBL584063 205647 0 None -19 2 Human 5.8 pKi = 5.8 Binding
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 530 7 2 6 4.8 C[C@@H](CNC(=O)c1ccc(Br)cc1NS(=O)(=O)c1cccc2nsnc12)c1ccccc1 10.1016/j.bmcl.2009.09.064
25033153 101296 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 502 4 1 6 4.2 O=C(c1ccc(Br)cc1NS(=O)(=O)c1c(Cl)nc2sccn12)N1CCCCC1 10.1016/j.bmcl.2007.09.087
CHEMBL251684 101296 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 502 4 1 6 4.2 O=C(c1ccc(Br)cc1NS(=O)(=O)c1c(Cl)nc2sccn12)N1CCCCC1 10.1016/j.bmcl.2007.09.087
25033227 161514 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 486 5 1 6 3.7 COC(=O)c1sccc1S(=O)(=O)Nc1cc(Br)ccc1C(=O)N1CCCCC1 10.1016/j.bmcl.2007.09.087
CHEMBL399918 161514 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 486 5 1 6 3.7 COC(=O)c1sccc1S(=O)(=O)Nc1cc(Br)ccc1C(=O)N1CCCCC1 10.1016/j.bmcl.2007.09.087
16090658 148296 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 420 4 1 6 3.3 O=C(c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nonc12)N1CCCCC1 10.1021/jm060590x
CHEMBL384573 148296 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 420 4 1 6 3.3 O=C(c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nonc12)N1CCCCC1 10.1021/jm060590x
16090792 148614 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 408 4 1 6 3.0 O=C(c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCC1 10.1021/jm060590x
CHEMBL386436 148614 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 408 4 1 6 3.0 O=C(c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCC1 10.1021/jm060590x
25033066 102680 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [125I]CCK8S from human CCK2RDisplacement of [125I]CCK8S from human CCK2R
ChEMBL 462 4 2 4 3.8 O=C(c1ccc(Br)cc1NS(=O)(=O)c1cccc2[nH]cnc12)N1CCCCC1 10.1016/j.bmc.2008.01.059
CHEMBL259224 102680 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [125I]CCK8S from human CCK2RDisplacement of [125I]CCK8S from human CCK2R
ChEMBL 462 4 2 4 3.8 O=C(c1ccc(Br)cc1NS(=O)(=O)c1cccc2[nH]cnc12)N1CCCCC1 10.1016/j.bmc.2008.01.059
16090658 148296 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [125I]CCK8S from human CCK2RDisplacement of [125I]CCK8S from human CCK2R
ChEMBL 420 4 1 6 3.3 O=C(c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nonc12)N1CCCCC1 10.1016/j.bmc.2008.01.059
CHEMBL384573 148296 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [125I]CCK8S from human CCK2RDisplacement of [125I]CCK8S from human CCK2R
ChEMBL 420 4 1 6 3.3 O=C(c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nonc12)N1CCCCC1 10.1016/j.bmc.2008.01.059
16732750 150761 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 531 7 2 5 4.2 O=C(CN1N=C(C2CCCCC2)c2ccccc2N(CC(=O)N2CCCC2)C1=O)Nc1cccc(C(=O)O)c1 10.1021/jm070139l
CHEMBL390275 150761 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 531 7 2 5 4.2 O=C(CN1N=C(C2CCCCC2)c2ccccc2N(CC(=O)N2CCCC2)C1=O)Nc1cccc(C(=O)O)c1 10.1021/jm070139l
44580900 195219 0 None -2 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]DAMGO from CCK2R-MOPR coexpressed in CHO cellsDisplacement of [3H]DAMGO from CCK2R-MOPR coexpressed in CHO cells
ChEMBL 1057 23 8 14 2.6 CN1C(=O)[C@H](NC(=O)Nc2cccc(OCCNC(=O)COCC(=O)NCCCCCCNC(=O)COCC(=O)N[C@H]3CC[C@@]4(O)[C@H]5Cc6cc(O)cc7c6[C@@]4(CCN5C)[C@H]3O7)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm800174p
CHEMBL502398 195219 0 None -2 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]DAMGO from CCK2R-MOPR coexpressed in CHO cellsDisplacement of [3H]DAMGO from CCK2R-MOPR coexpressed in CHO cells
ChEMBL 1057 23 8 14 2.6 CN1C(=O)[C@H](NC(=O)Nc2cccc(OCCNC(=O)COCC(=O)NCCCCCCNC(=O)COCC(=O)N[C@H]3CC[C@@]4(O)[C@H]5Cc6cc(O)cc7c6[C@@]4(CCN5C)[C@H]3O7)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm800174p
10771043 32925 0 None 61 2 Mouse 7.8 pKi = 7.8 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 707 10 4 4 6.9 O=C(O)c1cccc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm00021a019
CHEMBL135658 32925 0 None 61 2 Mouse 7.8 pKi = 7.8 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 707 10 4 4 6.9 O=C(O)c1cccc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm00021a019
11628273 146912 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 559 7 1 6 5.3 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(N3CCOCC3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
CHEMBL380193 146912 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 559 7 1 6 5.3 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(N3CCOCC3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
16733791 19954 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 572 8 2 7 4.9 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2ccc3ncn(CC(=O)O)c3c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL1190963 19954 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 572 8 2 7 4.9 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2ccc3ncn(CC(=O)O)c3c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL541904 19954 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 572 8 2 7 4.9 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2ccc3ncn(CC(=O)O)c3c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
44331524 170445 0 None 13 2 Human 7.8 pKi = 7.8 Binding
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 530 8 2 3 6.5 CC(CC1CCCC1)N1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(C(C)CC2CCCC2)c2ccccc21 10.1016/S0960-894X(96)00544-6
CHEMBL420459 170445 0 None 13 2 Human 7.8 pKi = 7.8 Binding
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 530 8 2 3 6.5 CC(CC1CCCC1)N1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(C(C)CC2CCCC2)c2ccccc21 10.1016/S0960-894X(96)00544-6
49798104 17617 0 None 7 3 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cells
ChEMBL 1381 39 14 13 3.5 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCC(=O)N(c1ccccc1)C1CCN(CCc2ccccc2)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2010.05.078
CHEMBL1172244 17617 0 None 7 3 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cells
ChEMBL 1381 39 14 13 3.5 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCC(=O)N(c1ccccc1)C1CCN(CCc2ccccc2)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2010.05.078
CHEMBL3350335 218253 0 None 245 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C 10.1021/jm00053a022
10819755 172221 0 None -52480 2 Rat 5.8 pKi = 5.8 Binding
Binding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomesBinding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomes
ChEMBL 976 28 9 11 1.6 CCCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm970477u
CHEMBL423907 172221 0 None -52480 2 Rat 5.8 pKi = 5.8 Binding
Binding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomesBinding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomes
ChEMBL 976 28 9 11 1.6 CCCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm970477u
44344617 120970 0 None - 1 Mouse 5.8 pKi = 5.8 Binding
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 633 8 2 5 5.2 CCC(=O)N1[C@H](C(=O)NCC(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2Cl)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
CHEMBL332949 120970 0 None - 1 Mouse 5.8 pKi = 5.8 Binding
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 633 8 2 5 5.2 CCC(=O)N1[C@H](C(=O)NCC(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2Cl)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
14802522 66346 0 None - 1 Mouse 6.8 pKi = 6.8 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 628 13 5 5 4.7 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CNC(=O)CCC(=O)O)Cc1ccccc1 10.1021/jm00087a011
CHEMBL171806 66346 0 None - 1 Mouse 6.8 pKi = 6.8 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 628 13 5 5 4.7 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CNC(=O)CCC(=O)O)Cc1ccccc1 10.1021/jm00087a011
3476 8182 9 None -117 3 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]BH-(Thr,-Nle)-CCK-9 from human CCK2 receptor expressed in COS-7 cells after 60 mins by gamma countingDisplacement of [125I]BH-(Thr,-Nle)-CCK-9 from human CCK2 receptor expressed in COS-7 cells after 60 mins by gamma counting
ChEMBL 408 3 2 3 3.7 O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 10.1021/jm200438b
59751 8182 9 None -117 3 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]BH-(Thr,-Nle)-CCK-9 from human CCK2 receptor expressed in COS-7 cells after 60 mins by gamma countingDisplacement of [125I]BH-(Thr,-Nle)-CCK-9 from human CCK2 receptor expressed in COS-7 cells after 60 mins by gamma counting
ChEMBL 408 3 2 3 3.7 O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 10.1021/jm200438b
878 8182 9 None -117 3 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]BH-(Thr,-Nle)-CCK-9 from human CCK2 receptor expressed in COS-7 cells after 60 mins by gamma countingDisplacement of [125I]BH-(Thr,-Nle)-CCK-9 from human CCK2 receptor expressed in COS-7 cells after 60 mins by gamma counting
ChEMBL 408 3 2 3 3.7 O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 10.1021/jm200438b
CHEMBL39263 8182 9 None -117 3 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]BH-(Thr,-Nle)-CCK-9 from human CCK2 receptor expressed in COS-7 cells after 60 mins by gamma countingDisplacement of [125I]BH-(Thr,-Nle)-CCK-9 from human CCK2 receptor expressed in COS-7 cells after 60 mins by gamma counting
ChEMBL 408 3 2 3 3.7 O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 10.1021/jm200438b
52949124 7663 4 None 2 2 Human 6.8 pKi = 6.8 Binding
Displacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
9055 7663 4 None 2 2 Human 6.8 pKi = 6.8 Binding
Displacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
CHEMBL1269258 7663 4 None 2 2 Human 6.8 pKi = 6.8 Binding
Displacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
DB12694 7663 4 None 2 2 Human 6.8 pKi = 6.8 Binding
Displacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
CHEMBL3351058 218319 0 None 83 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL None None None CC(C)(C)OC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1cccc2ccccc12)C1CCCCC1 10.1021/jm00053a022
10676196 126018 0 None 234 2 Mouse 7.8 pKi = 7.8 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 699 11 5 5 6.0 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC2CCCCC2)cc(C(=O)O)c1 10.1021/jm00021a019
CHEMBL343515 126018 0 None 234 2 Mouse 7.8 pKi = 7.8 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 699 11 5 5 6.0 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC2CCCCC2)cc(C(=O)O)c1 10.1021/jm00021a019
44351444 123664 0 None -1 2 Human 7.8 pKi = 7.8 Binding
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 622 8 3 6 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(F)cc2F)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL338300 123664 0 None -1 2 Human 7.8 pKi = 7.8 Binding
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 622 8 3 6 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(F)cc2F)C[C@@H]1C(=O)O 10.1021/jm970439a
44356666 175408 0 None 16 2 Mouse 7.8 pKi = 7.8 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 799 11 3 11 5.2 O=C(NCC12CC3CC(CC(C3)C1)C2)C1C2c3ccccc3C(c3ccccc32)C1C(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1cc(-n2cnnn2)cc(-n2cnnn2)c1 10.1021/jm00021a019
CHEMBL436187 175408 0 None 16 2 Mouse 7.8 pKi = 7.8 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 799 11 3 11 5.2 O=C(NCC12CC3CC(CC(C3)C1)C2)C1C2c3ccccc3C(c3ccccc32)C1C(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1cc(-n2cnnn2)cc(-n2cnnn2)c1 10.1021/jm00021a019
11571142 142584 0 None -10 3 Mouse 7.8 pKi = 7.8 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 489 7 3 3 6.7 CC1(c2nc(C(=O)Nc3cccc(C(=O)O)c3)c(CCC34CC5CC(CC(C5)C3)C4)[nH]2)CCCCC1 10.1021/jm0490686
CHEMBL373050 142584 0 None -10 3 Mouse 7.8 pKi = 7.8 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 489 7 3 3 6.7 CC1(c2nc(C(=O)Nc3cccc(C(=O)O)c3)c(CCC34CC5CC(CC(C5)C3)C4)[nH]2)CCCCC1 10.1021/jm0490686
CHEMBL3351060 218320 0 None -20 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL None None None CN(C(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1cccc2ccccc12)c1ccccc1)[C@@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C 10.1021/jm00053a022
CHEMBL379405 219044 0 None -10 4 Human 5.8 pKi = 5.8 Binding
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm050921q
44408411 168089 0 None -3548 4 Human 5.8 pKi = 5.8 Binding
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1242 31 11 15 4.4 CCCC[C@@H](C(=O)N[C@@H](Cc1cn(C(C)=O)c2ccccc12)C(=O)O)N(C(=O)Nc1ccccc1Cl)C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)N(C)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O 10.1021/jm050851n
CHEMBL412331 168089 0 None -3548 4 Human 5.8 pKi = 5.8 Binding
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1242 31 11 15 4.4 CCCC[C@@H](C(=O)N[C@@H](Cc1cn(C(C)=O)c2ccccc12)C(=O)O)N(C(=O)Nc1ccccc1Cl)C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)N(C)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O 10.1021/jm050851n
10645976 23366 0 None -23988 5 Human 4.8 pKi = 4.8 Binding
Binding affinity against Cholecystokinin type B receptor using [3H](MeNLE28,31)-CCK-8 as radioligand in guinea pig cerebral cortex.Binding affinity against Cholecystokinin type B receptor using [3H](MeNLE28,31)-CCK-8 as radioligand in guinea pig cerebral cortex.
ChEMBL 423 5 1 4 4.9 CN1c2ccc(Cl)cc2C(c2ccccc2)=NCC1CCNC(=O)c1cccs1 10.1021/jm950423p
CHEMBL124015 23366 0 None -23988 5 Human 4.8 pKi = 4.8 Binding
Binding affinity against Cholecystokinin type B receptor using [3H](MeNLE28,31)-CCK-8 as radioligand in guinea pig cerebral cortex.Binding affinity against Cholecystokinin type B receptor using [3H](MeNLE28,31)-CCK-8 as radioligand in guinea pig cerebral cortex.
ChEMBL 423 5 1 4 4.9 CN1c2ccc(Cl)cc2C(c2ccccc2)=NCC1CCNC(=O)c1cccs1 10.1021/jm950423p
10555325 19721 0 None 45 2 Mouse 6.8 pKi = 6.8 Binding
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 585 7 2 5 4.2 CC(=O)N1[C@H](C(=O)NCC(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
CHEMBL118930 19721 0 None 45 2 Mouse 6.8 pKi = 6.8 Binding
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 585 7 2 5 4.2 CC(=O)N1[C@H](C(=O)NCC(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
44280162 106232 0 None 21 2 Rat 6.8 pKi = 6.8 Binding
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 667 8 3 5 6.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1CC[C@H](Oc2ccc(Cl)cc2Cl)C[C@@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
CHEMBL283040 106232 0 None 21 2 Rat 6.8 pKi = 6.8 Binding
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 667 8 3 5 6.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1CC[C@H](Oc2ccc(Cl)cc2Cl)C[C@@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
10747345 123756 0 None 6 2 Mouse 6.8 pKi = 6.8 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 707 10 4 4 6.9 O=C(O)c1ccccc1NC(=O)[C@H](Cc1ccccc1)NC(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC12CC3CC(CC(C3)C1)C2 10.1021/jm00021a019
CHEMBL338728 123756 0 None 6 2 Mouse 6.8 pKi = 6.8 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 707 10 4 4 6.9 O=C(O)c1ccccc1NC(=O)[C@H](Cc1ccccc1)NC(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC12CC3CC(CC(C3)C1)C2 10.1021/jm00021a019
10327028 96230 0 None -1 3 Rat 7.8 pKi = 7.8 Binding
Affinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cellsAffinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cells
ChEMBL 660 11 7 6 2.0 C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm9603072
CHEMBL2371222 96230 0 None -1 3 Rat 7.8 pKi = 7.8 Binding
Affinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cellsAffinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cells
ChEMBL 660 11 7 6 2.0 C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm9603072
44387568 68981 0 None -1 3 Rat 7.8 pKi = 7.8 Binding
Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.
ChEMBL 660 11 7 6 2.0 C[C@@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm0000416
CHEMBL177799 68981 0 None -1 3 Rat 7.8 pKi = 7.8 Binding
Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.
ChEMBL 660 11 7 6 2.0 C[C@@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm0000416
5311201 214174 35 None -27 6 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]CCK-26-33 from CCK2 receptor expressed in CHO cellsDisplacement of [125I]CCK-26-33 from CCK2 receptor expressed in CHO cells
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm800174p
CHEMBL9387 214174 35 None -27 6 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]CCK-26-33 from CCK2 receptor expressed in CHO cellsDisplacement of [125I]CCK-26-33 from CCK2 receptor expressed in CHO cells
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm800174p
CHEMBL1172251 215362 0 None -2 4 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2010.05.078
10257865 215217 4 None -3 5 Rat 7.7 pKi = 7.7 Binding
Tested for binding affinity towards CCK-B in rat cortex by displacement of [3H]pBC264 radioligandTested for binding affinity towards CCK-B in rat cortex by displacement of [3H]pBC264 radioligand
ChEMBL 591 10 3 4 5.8 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccc(Cl)cc1)CC(=O)O 10.1021/jm00072a005
CHEMBL99939 215217 4 None -3 5 Rat 7.7 pKi = 7.7 Binding
Tested for binding affinity towards CCK-B in rat cortex by displacement of [3H]pBC264 radioligandTested for binding affinity towards CCK-B in rat cortex by displacement of [3H]pBC264 radioligand
ChEMBL 591 10 3 4 5.8 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccc(Cl)cc1)CC(=O)O 10.1021/jm00072a005
10793952 109558 0 None - 1 Rat 7.7 pKi = 7.7 Binding
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 621 8 3 5 5.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1C[C@H](Oc2ccc(F)cc2F)C[C@@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
CHEMBL30524 109558 0 None - 1 Rat 7.7 pKi = 7.7 Binding
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 621 8 3 5 5.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1C[C@H](Oc2ccc(F)cc2F)C[C@@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
44351444 123664 0 None 1 2 Rat 7.7 pKi = 7.7 Binding
Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.
ChEMBL 622 8 3 6 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(F)cc2F)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL338300 123664 0 None 1 2 Rat 7.7 pKi = 7.7 Binding
Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.
ChEMBL 622 8 3 6 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(F)cc2F)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL1172428 215365 0 None -47 3 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2010.05.078
57395574 75181 0 None - 1 Human 4.8 pKi = 4.8 Binding
Displacement of Eu-DTAP-CCK8-NH2 from CCK2 receptor expressed in human HEK293 cells after 1 hr by time resolved fluorescence methodDisplacement of Eu-DTAP-CCK8-NH2 from CCK2 receptor expressed in human HEK293 cells after 1 hr by time resolved fluorescence method
ChEMBL 817 26 7 10 2.8 CCCCc1cn(CCCCCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)nn1 10.1016/j.bmc.2011.08.053
CHEMBL1917060 75181 0 None - 1 Human 4.8 pKi = 4.8 Binding
Displacement of Eu-DTAP-CCK8-NH2 from CCK2 receptor expressed in human HEK293 cells after 1 hr by time resolved fluorescence methodDisplacement of Eu-DTAP-CCK8-NH2 from CCK2 receptor expressed in human HEK293 cells after 1 hr by time resolved fluorescence method
ChEMBL 817 26 7 10 2.8 CCCCc1cn(CCCCCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)nn1 10.1016/j.bmc.2011.08.053
11562579 139522 0 None - 1 Mouse 6.7 pKi = 6.7 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 513 8 3 4 6.5 COc1ccc(NC(=O)c2[nH]c(-c3ccccc3C)nc2CCC23CC4CC(CC(C4)C2)C3)cc1C(=O)O 10.1021/jm0490686
CHEMBL369974 139522 0 None - 1 Mouse 6.7 pKi = 6.7 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 513 8 3 4 6.5 COc1ccc(NC(=O)c2[nH]c(-c3ccccc3C)nc2CCC23CC4CC(CC(C4)C2)C3)cc1C(=O)O 10.1021/jm0490686
9983949 214520 0 None 23 2 Human 6.7 pKi = 6.7 Binding
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 513 9 3 3 5.8 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCCc1ccccc1 10.1021/jm00072a005
CHEMBL95793 214520 0 None 23 2 Human 6.7 pKi = 6.7 Binding
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 513 9 3 3 5.8 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCCc1ccccc1 10.1021/jm00072a005
10460621 113955 0 None 8 2 Human 6.7 pKi = 6.7 Binding
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 567 8 3 3 6.7 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccc(Cl)c(Cl)c1 10.1021/jm00072a005
CHEMBL316462 113955 0 None 8 2 Human 6.7 pKi = 6.7 Binding
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 567 8 3 3 6.7 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccc(Cl)c(Cl)c1 10.1021/jm00072a005
11539356 78455 0 None -8 3 Mouse 6.7 pKi = 6.7 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 435 7 3 3 5.6 CC(C)c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
CHEMBL196441 78455 0 None -8 3 Mouse 6.7 pKi = 6.7 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 435 7 3 3 5.6 CC(C)c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
10841267 178297 0 None - 1 Mouse 6.7 pKi = 6.7 Binding
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 599 7 2 5 4.6 CC(=O)N1[C@H](C(=O)N[C@@H](C)C(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
CHEMBL446414 178297 0 None - 1 Mouse 6.7 pKi = 6.7 Binding
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 599 7 2 5 4.6 CC(=O)N1[C@H](C(=O)N[C@@H](C)C(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
10626664 117164 0 None - 1 Rat 5.7 pKi = 5.7 Binding
Inhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranesInhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranes
ChEMBL 559 7 3 5 4.1 CC(C)(C)OC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@@H]12 10.1021/jm9703247
CHEMBL324294 117164 0 None - 1 Rat 5.7 pKi = 5.7 Binding
Inhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranesInhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranes
ChEMBL 559 7 3 5 4.1 CC(C)(C)OC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@@H]12 10.1021/jm9703247
CHEMBL120632 215384 33 None 5 3 Human 7.7 pKi = 7.7 Binding
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL None None None CSCC[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm0000416
9832467 151071 0 None -22 5 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 477 7 3 4 5.9 O=C(O)c1cccc(NC(=O)c2nc(C3CCCCC3)[nH]c2COC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm070139l
CHEMBL390519 151071 0 None -22 5 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 477 7 3 4 5.9 O=C(O)c1cccc(NC(=O)c2nc(C3CCCCC3)[nH]c2COC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm070139l
CHEMBL120632 215384 33 None 5 3 Human 7.7 pKi = 7.7 Binding
Inhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptorInhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptor
ChEMBL None None None CSCC[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm9603072
44351455 123597 0 None 1 2 Rat 7.7 pKi = 7.7 Binding
Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.
ChEMBL 604 8 3 6 4.6 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(F)cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL337934 123597 0 None 1 2 Rat 7.7 pKi = 7.7 Binding
Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.
ChEMBL 604 8 3 6 4.6 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(F)cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL1172429 215366 0 None -120 4 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2010.05.078
9957602 162167 0 None - 1 Mouse 6.7 pKi = 6.7 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 499 8 3 3 5.5 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC12CC3CC(CC(C3)C1)C2)C(=O)NCCc1ccccc1 10.1021/jm00087a011
CHEMBL40352 162167 0 None - 1 Mouse 6.7 pKi = 6.7 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 499 8 3 3 5.5 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC12CC3CC(CC(C3)C1)C2)C(=O)NCCc1ccccc1 10.1021/jm00087a011
44346908 23227 0 None - 1 Mouse 6.7 pKi = 6.7 Binding
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 526 6 2 4 4.4 COC(=O)[C@H](C)NC(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC1C2CC3CC(C2)CC1C3 10.1021/jm00048a001
CHEMBL123344 23227 0 None - 1 Mouse 6.7 pKi = 6.7 Binding
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 526 6 2 4 4.4 COC(=O)[C@H](C)NC(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC1C2CC3CC(C2)CC1C3 10.1021/jm00048a001
44346909 121361 0 None 10 2 Mouse 5.7 pKi = 5.7 Binding
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 498 6 3 3 3.9 O=C(O)CNC(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC1C2CC3CC(C2)CC1C3 10.1021/jm00048a001
CHEMBL333758 121361 0 None 10 2 Mouse 5.7 pKi = 5.7 Binding
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 498 6 3 3 3.9 O=C(O)CNC(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC1C2CC3CC(C2)CC1C3 10.1021/jm00048a001
11705988 173131 0 None 1 2 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 498 7 2 6 4.4 CNc1cccc(NC(=O)CN2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
CHEMBL427387 173131 0 None 1 2 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 498 7 2 6 4.4 CNc1cccc(NC(=O)CN2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
44346355 164646 0 None -30 3 Rat 6.7 pKi = 6.7 Binding
Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.
ChEMBL 1260 26 13 15 1.7 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CCCCNC(=O)C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc2ccc(OS(=O)(=O)O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm0000416
CHEMBL408389 164646 0 None -30 3 Rat 6.7 pKi = 6.7 Binding
Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.
ChEMBL 1260 26 13 15 1.7 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CCCCNC(=O)C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc2ccc(OS(=O)(=O)O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm0000416
16090649 89248 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 448 4 1 6 3.9 C[C@H]1C=C[C@@H](C)N1C(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1021/jm060590x
CHEMBL217648 89248 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 448 4 1 6 3.9 C[C@H]1C=C[C@@H](C)N1C(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1021/jm060590x
9936141 19034 0 None 12 2 Mouse 6.7 pKi = 6.7 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 510 7 4 3 7.0 O=C(O)c1cc(NC(=O)c2cc(-c3ccc4ccccc4c3)[nH]c2CC2CCCCCC2)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL1184700 19034 0 None 12 2 Mouse 6.7 pKi = 6.7 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 510 7 4 3 7.0 O=C(O)c1cc(NC(=O)c2cc(-c3ccc4ccccc4c3)[nH]c2CC2CCCCCC2)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL2067956 19034 0 None 12 2 Mouse 6.7 pKi = 6.7 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 510 7 4 3 7.0 O=C(O)c1cc(NC(=O)c2cc(-c3ccc4ccccc4c3)[nH]c2CC2CCCCCC2)cc(C(=O)O)c1 10.1021/jm049069y
11605951 19058 0 None 25 2 Mouse 6.7 pKi = 6.7 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 512 8 4 3 6.5 O=C(O)c1cc(NC(=O)c2cc(-c3ccccc3)[nH]c2CCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL1184851 19058 0 None 25 2 Mouse 6.7 pKi = 6.7 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 512 8 4 3 6.5 O=C(O)c1cc(NC(=O)c2cc(-c3ccccc3)[nH]c2CCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL2067961 19058 0 None 25 2 Mouse 6.7 pKi = 6.7 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 512 8 4 3 6.5 O=C(O)c1cc(NC(=O)c2cc(-c3ccccc3)[nH]c2CCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm049069y
44445282 101292 0 None - 1 Human 5.7 pKi = 5.7 Binding
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 481 5 1 5 4.1 Cc1ccc(S(=O)(=O)Nc2cc(Br)ccc2C(=O)N2CCCCC2)cc1[N+](=O)[O-] 10.1016/j.bmcl.2007.09.087
CHEMBL251651 101292 0 None - 1 Human 5.7 pKi = 5.7 Binding
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 481 5 1 5 4.1 Cc1ccc(S(=O)(=O)Nc2cc(Br)ccc2C(=O)N2CCCCC2)cc1[N+](=O)[O-] 10.1016/j.bmcl.2007.09.087
16090700 89238 0 None -10 2 Human 5.7 pKi = 5.7 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 541 8 4 4 4.2 O=C(N[C@@H](Cc1ccccc1)C(=O)O)c1ccc(Br)cc1NS(=O)(=O)c1cc2ccccc2[nH]1 10.1021/jm060590x
CHEMBL217595 89238 0 None -10 2 Human 5.7 pKi = 5.7 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 541 8 4 4 4.2 O=C(N[C@@H](Cc1ccccc1)C(=O)O)c1ccc(Br)cc1NS(=O)(=O)c1cc2ccccc2[nH]1 10.1021/jm060590x
16090702 172977 0 None -1 2 Human 5.7 pKi = 5.7 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 461 4 2 3 4.4 O=C(c1ccc(Br)cc1NS(=O)(=O)c1cc2ccccc2[nH]1)N1CCCCC1 10.1021/jm060590x
CHEMBL426524 172977 0 None -1 2 Human 5.7 pKi = 5.7 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 461 4 2 3 4.4 O=C(c1ccc(Br)cc1NS(=O)(=O)c1cc2ccccc2[nH]1)N1CCCCC1 10.1021/jm060590x
25033064 102793 0 None - 1 Human 5.7 pKi = 5.7 Binding
Displacement of [125I]CCK8S from human CCK2RDisplacement of [125I]CCK8S from human CCK2R
ChEMBL 477 4 1 6 3.2 Cn1nnc2c(S(=O)(=O)Nc3cc(Br)ccc3C(=O)N3CCCCC3)cccc21 10.1016/j.bmc.2008.01.059
CHEMBL259751 102793 0 None - 1 Human 5.7 pKi = 5.7 Binding
Displacement of [125I]CCK8S from human CCK2RDisplacement of [125I]CCK8S from human CCK2R
ChEMBL 477 4 1 6 3.2 Cn1nnc2c(S(=O)(=O)Nc3cc(Br)ccc3C(=O)N3CCCCC3)cccc21 10.1016/j.bmc.2008.01.059
5311201 214174 35 None -27 6 Human 8.7 pKi = 8.7 Binding
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm970439a
CHEMBL9387 214174 35 None -27 6 Human 8.7 pKi = 8.7 Binding
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm970439a
118718859 122197 1 None - 1 Mouse 8.7 pKi = 8.7 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 616 12 5 5 5.2 CC1(C)[C@H]2CC[C@@]1(C)[C@@H](OC(=O)N[C@](C)(Cc1c[nH]c3ccccc13)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1)C2 10.1021/jm00087a011
CHEMBL3350364 122197 1 None - 1 Mouse 8.7 pKi = 8.7 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 616 12 5 5 5.2 CC1(C)[C@H]2CC[C@@]1(C)[C@@H](OC(=O)N[C@](C)(Cc1c[nH]c3ccccc13)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1)C2 10.1021/jm00087a011
44346326 120116 0 None 46 2 Human 8.7 pKi = 8.7 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 588 5 2 7 6.5 O=C(Nc1cccc(C2N=NN=N2)c1)NC1C(=O)N(c2ccccc2)c2ccccc2N(C2[C@H]3C[C@@H]4C[C@@H](C[C@H]2C4)C3)C1=O 10.1021/jm990967h
CHEMBL331688 120116 0 None 46 2 Human 8.7 pKi = 8.7 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 588 5 2 7 6.5 O=C(Nc1cccc(C2N=NN=N2)c1)NC1C(=O)N(c2ccccc2)c2ccccc2N(C2[C@H]3C[C@@H]4C[C@@H](C[C@H]2C4)C3)C1=O 10.1021/jm990967h
10576324 120741 0 None 54 2 Human 8.7 pKi = 8.7 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 470 6 2 3 5.3 CC(C)CC(C)N1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21 10.1021/jm990967h
CHEMBL332595 120741 0 None 54 2 Human 8.7 pKi = 8.7 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 470 6 2 3 5.3 CC(C)CC(C)N1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21 10.1021/jm990967h
CHEMBL265595 217434 0 None 120 4 Human 8.7 pKi = 8.7 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor was determinedBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor was determined
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O 10.1021/jm0303103
CHEMBL411201 219651 0 None 3 4 Human 8.7 pKi = 8.7 Binding
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor was determinedBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor was determined
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm0303103
CHEMBL407057 219414 0 None 120 4 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O 10.1021/jm050921q
16732909 92232 0 None 2 3 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 532 8 2 5 5.1 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL226673 92232 0 None 2 3 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 532 8 2 5 5.1 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
15755206 122254 0 None - 1 Mouse 8.7 pKi = 8.7 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 614 11 5 5 5.0 CC1(C)C2CCC1(C)[C@@H](OC(=O)N[C@](C)(Cc1c[nH]c3ccccc13)C(=O)NC[C@H](NC(=O)/C=C/C(=O)O)c1ccccc1)C2 10.1021/jm00087a011
CHEMBL3351023 122254 0 None - 1 Mouse 8.7 pKi = 8.7 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 614 11 5 5 5.0 CC1(C)C2CCC1(C)[C@@H](OC(=O)N[C@](C)(Cc1c[nH]c3ccccc13)C(=O)NC[C@H](NC(=O)/C=C/C(=O)O)c1ccccc1)C2 10.1021/jm00087a011
44356825 175412 0 None 1621 2 Mouse 8.7 pKi = 8.7 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 767 11 6 6 6.3 O=C(O)c1cc(NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm00021a019
CHEMBL436209 175412 0 None 1621 2 Mouse 8.7 pKi = 8.7 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 767 11 6 6 6.3 O=C(O)c1cc(NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm00021a019
5311201 214174 35 None -27 6 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00053a022
CHEMBL9387 214174 35 None -27 6 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00053a022
11547802 142781 0 None 177 2 Mouse 8.7 pKi = 8.7 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 497 8 3 3 6.4 Cc1ccccc1-c1nc(C(=O)Nc2cccc(CC(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
CHEMBL373168 142781 0 None 177 2 Mouse 8.7 pKi = 8.7 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 497 8 3 3 6.4 Cc1ccccc1-c1nc(C(=O)Nc2cccc(CC(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
9850043 119333 2 None 309 2 Human 8.6 pKi = 8.6 Binding
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 534 5 2 3 6.1 O=C(Nc1ccccc1)NC1C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc2N(c2ccccc2)C1=O 10.1016/S0960-894X(96)00544-6
CHEMBL329984 119333 2 None 309 2 Human 8.6 pKi = 8.6 Binding
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 534 5 2 3 6.1 O=C(Nc1ccccc1)NC1C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc2N(c2ccccc2)C1=O 10.1016/S0960-894X(96)00544-6
9850043 119650 2 None 1 3 Human 8.6 pKi = 8.6 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 534 5 2 3 6.1 O=C(Nc1ccccc1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
CHEMBL330977 119650 2 None 1 3 Human 8.6 pKi = 8.6 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 534 5 2 3 6.1 O=C(Nc1ccccc1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
44356887 38091 0 None 776 2 Mouse 8.6 pKi = 8.6 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 757 11 5 6 6.7 O=C(O)c1cc(NC(=O)[C@@H](Cc2ccsc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm00021a019
CHEMBL140179 38091 0 None 776 2 Mouse 8.6 pKi = 8.6 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 757 11 5 6 6.7 O=C(O)c1cc(NC(=O)[C@@H](Cc2ccsc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm00021a019
10745516 21129 0 None 60 2 Human 8.6 pKi = 8.6 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 563 5 2 4 5.8 CN(C)c1cccc(NC(=O)NC2C(=O)N(c3ccccc3)c3ccccc3N(C3[C@H]4C[C@@H]5C[C@@H](C[C@H]3C5)C4)C2=O)c1 10.1021/jm990967h
CHEMBL120015 21129 0 None 60 2 Human 8.6 pKi = 8.6 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 563 5 2 4 5.8 CN(C)c1cccc(NC(=O)NC2C(=O)N(c3ccccc3)c3ccccc3N(C3[C@H]4C[C@@H]5C[C@@H](C[C@H]3C5)C4)C2=O)c1 10.1021/jm990967h
44331505 11125 0 None 25 2 Human 8.6 pKi = 8.6 Binding
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 450 8 2 3 4.6 CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(CCC(C)C)c2ccccc21 10.1016/S0960-894X(96)00544-6
CHEMBL101063 11125 0 None 25 2 Human 8.6 pKi = 8.6 Binding
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 450 8 2 3 4.6 CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(CCC(C)C)c2ccccc21 10.1016/S0960-894X(96)00544-6
10256780 119456 0 None 234 2 Human 8.6 pKi = 8.6 Binding
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 540 5 2 3 6.1 O=C(Nc1ccccc1)NC1C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc2N(C2CCCCC2)C1=O 10.1016/S0960-894X(96)00544-6
CHEMBL330409 119456 0 None 234 2 Human 8.6 pKi = 8.6 Binding
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 540 5 2 3 6.1 O=C(Nc1ccccc1)NC1C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc2N(C2CCCCC2)C1=O 10.1016/S0960-894X(96)00544-6
10603576 21284 0 None 19 2 Human 8.6 pKi = 8.6 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 594 8 2 7 5.6 CC(C)Cn1nnc(-c2cccc(NC(=O)NC3C(=O)N(CCC(C)(C)C)c4ccccc4N(c4ccccc4)C3=O)c2)n1 10.1021/jm990967h
CHEMBL120168 21284 0 None 19 2 Human 8.6 pKi = 8.6 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 594 8 2 7 5.6 CC(C)Cn1nnc(-c2cccc(NC(=O)NC3C(=O)N(CCC(C)(C)C)c4ccccc4N(c4ccccc4)C3=O)c2)n1 10.1021/jm990967h
9914672 115319 0 None 31 2 Human 8.6 pKi = 8.6 Binding
Binding affinity at human CCK2 receptorBinding affinity at human CCK2 receptor
ChEMBL 521 5 2 4 3.7 O=C(Nc1ccc(F)cc1)N[C@H]1C(=O)N(CC(=O)N2CCCC2)c2ccccc2N(C2CCCCC2)C1=O 10.1016/j.bmc.2007.12.047
CHEMBL320141 115319 0 None 31 2 Human 8.6 pKi = 8.6 Binding
Binding affinity at human CCK2 receptorBinding affinity at human CCK2 receptor
ChEMBL 521 5 2 4 3.7 O=C(Nc1ccc(F)cc1)N[C@H]1C(=O)N(CC(=O)N2CCCC2)c2ccccc2N(C2CCCCC2)C1=O 10.1016/j.bmc.2007.12.047
9914672 115319 0 None 31 2 Human 8.6 pKi = 8.6 Binding
Tested for its selectivity against human Cholecystokinin type B receptor isolated from a human temporal cortex cDNA library and stably transfected into a HeLa cell line. (n=1)Tested for its selectivity against human Cholecystokinin type B receptor isolated from a human temporal cortex cDNA library and stably transfected into a HeLa cell line. (n=1)
ChEMBL 521 5 2 4 3.7 O=C(Nc1ccc(F)cc1)N[C@H]1C(=O)N(CC(=O)N2CCCC2)c2ccccc2N(C2CCCCC2)C1=O 10.1016/S0960-894X(96)00613-0
CHEMBL320141 115319 0 None 31 2 Human 8.6 pKi = 8.6 Binding
Tested for its selectivity against human Cholecystokinin type B receptor isolated from a human temporal cortex cDNA library and stably transfected into a HeLa cell line. (n=1)Tested for its selectivity against human Cholecystokinin type B receptor isolated from a human temporal cortex cDNA library and stably transfected into a HeLa cell line. (n=1)
ChEMBL 521 5 2 4 3.7 O=C(Nc1ccc(F)cc1)N[C@H]1C(=O)N(CC(=O)N2CCCC2)c2ccccc2N(C2CCCCC2)C1=O 10.1016/S0960-894X(96)00613-0
10699583 103186 0 None - 1 Human 8.6 pKi = 8.6 Binding
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 664 19 6 7 1.0 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)COC 10.1021/jm0000416
CHEMBL261934 103186 0 None - 1 Human 8.6 pKi = 8.6 Binding
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 664 19 6 7 1.0 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)COC 10.1021/jm0000416
44331489 11047 0 None 32 2 Human 8.6 pKi = 8.6 Binding
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 493 9 2 4 4.7 CC(C)CCN1C(=O)C(NC(=O)Nc2cccc(N(C)C)c2)C(=O)N(CCC(C)C)c2ccccc21 10.1016/S0960-894X(96)00544-6
CHEMBL100618 11047 0 None 32 2 Human 8.6 pKi = 8.6 Binding
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 493 9 2 4 4.7 CC(C)CCN1C(=O)C(NC(=O)Nc2cccc(N(C)C)c2)C(=O)N(CCC(C)C)c2ccccc21 10.1016/S0960-894X(96)00544-6
CHEMBL333477 218171 0 None -19 3 Rat 8.6 pKi = 8.6 Binding
Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm0000416
10795116 34688 0 None 602 2 Mouse 8.6 pKi = 8.6 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 743 11 5 5 6.7 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCc2ccc3ccccc3c2)cc(C(=O)O)c1 10.1021/jm00021a019
CHEMBL137180 34688 0 None 602 2 Mouse 8.6 pKi = 8.6 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 743 11 5 5 6.7 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCc2ccc3ccccc3c2)cc(C(=O)O)c1 10.1021/jm00021a019
11803482 123978 0 None - 1 Human 8.6 pKi = 8.6 Binding
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 807 21 8 9 1.8 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@H](NC(=O)OC(C)(C)C)C(=O)O 10.1021/jm0000416
CHEMBL339421 123978 0 None - 1 Human 8.6 pKi = 8.6 Binding
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 807 21 8 9 1.8 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@H](NC(=O)OC(C)(C)C)C(=O)O 10.1021/jm0000416
CHEMBL205965 215948 0 None 31 3 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
16732594 21139 0 None 2511 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 572 8 2 7 4.9 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc3c2cnn3CC(=O)O)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL1161950 21139 0 None 2511 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 572 8 2 7 4.9 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc3c2cnn3CC(=O)O)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL1200187 21139 0 None 2511 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 572 8 2 7 4.9 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc3c2cnn3CC(=O)O)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL3351053 218316 0 None 426 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1cccc2ccccc12)C(=O)N(C)[C@@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C 10.1021/jm00053a022
4627 7609 50 None 1 5 Rat 8.6 pKi = 8.6 Binding
Inhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranesInhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranes
ChEMBL None None None None 10.1021/jm9703247
864 7609 50 None 1 5 Rat 8.6 pKi = 8.6 Binding
Inhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranesInhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranes
ChEMBL None None None None 10.1021/jm9703247
9833444 7609 50 None 1 5 Rat 8.6 pKi = 8.6 Binding
Inhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranesInhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranes
ChEMBL None None None None 10.1021/jm9703247
CHEMBL1121 7609 50 None 1 5 Rat 8.6 pKi = 8.6 Binding
Inhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranesInhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranes
ChEMBL None None None None 10.1021/jm9703247
DB09142 7609 50 None 1 5 Rat 8.6 pKi = 8.6 Binding
Inhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranesInhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranes
ChEMBL None None None None 10.1021/jm9703247
9850043 119650 2 None -1 3 Rat 8.6 pKi = 8.6 Binding
Inhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of rat pancreatic membranesInhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of rat pancreatic membranes
ChEMBL 534 5 2 3 6.1 O=C(Nc1ccccc1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
CHEMBL330977 119650 2 None -1 3 Rat 8.6 pKi = 8.6 Binding
Inhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of rat pancreatic membranesInhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of rat pancreatic membranes
ChEMBL 534 5 2 3 6.1 O=C(Nc1ccccc1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
10626579 22283 0 None 38 2 Human 8.5 pKi = 8.5 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 554 6 2 4 6.2 CC(C)(C)CCN1C(=O)C(NC(=O)Nc2cccc(OC(F)(F)F)c2)C(=O)N(c2ccccc2)c2ccccc21 10.1021/jm990967h
CHEMBL121703 22283 0 None 38 2 Human 8.5 pKi = 8.5 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 554 6 2 4 6.2 CC(C)(C)CCN1C(=O)C(NC(=O)Nc2cccc(OC(F)(F)F)c2)C(=O)N(c2ccccc2)c2ccccc21 10.1021/jm990967h
10651325 20650 0 None 275 2 Human 8.5 pKi = 8.5 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 606 7 2 5 6.3 CCOC(=O)c1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 10.1021/jm990967h
CHEMBL119608 20650 0 None 275 2 Human 8.5 pKi = 8.5 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 606 7 2 5 6.3 CCOC(=O)c1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 10.1021/jm990967h
5311201 214174 35 None -27 6 Human 8.5 pKi = 8.5 Binding
Inhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of guinea pigInhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of guinea pig
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm990967h
CHEMBL9387 214174 35 None -27 6 Human 8.5 pKi = 8.5 Binding
Inhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of guinea pigInhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of guinea pig
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm990967h
44351491 123680 0 None - 1 Human 7.7 pKi = 7.7 Binding
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 570 7 3 5 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](c2ccccc2)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL338382 123680 0 None - 1 Human 7.7 pKi = 7.7 Binding
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 570 7 3 5 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](c2ccccc2)C[C@@H]1C(=O)O 10.1021/jm970439a
10256428 122249 0 None - 1 Mouse 7.7 pKi = 7.7 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 529 9 4 4 4.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC12CC3CC(CC(C3)C1)C2)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00087a011
CHEMBL3351017 122249 0 None - 1 Mouse 7.7 pKi = 7.7 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 529 9 4 4 4.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC12CC3CC(CC(C3)C1)C2)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00087a011
11513177 79304 0 None -8 3 Mouse 7.7 pKi = 7.7 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 501 7 3 3 6.7 O=C(O)c1cccc(NC(=O)c2[nH]c(C34CCC(CC3)CC4)nc2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
CHEMBL199091 79304 0 None -8 3 Mouse 7.7 pKi = 7.7 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 501 7 3 3 6.7 O=C(O)c1cccc(NC(=O)c2[nH]c(C34CCC(CC3)CC4)nc2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
16731870 104174 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 490 8 2 4 5.6 CC(C)CCN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL269790 104174 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 490 8 2 4 5.6 CC(C)CCN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
136036821 102583 0 None 3 3 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 602 9 2 7 5.6 CC(C)(C)C(=O)CN1C(=O)N(CCCC(=O)Nc2cccc(-c3nc(=O)o[nH]3)c2)C(=O)N(C2CCCCC2)c2ccccc21 10.1016/j.bmc.2007.12.047
CHEMBL258782 102583 0 None 3 3 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 602 9 2 7 5.6 CC(C)(C)C(=O)CN1C(=O)N(CCCC(=O)Nc2cccc(-c3nc(=O)o[nH]3)c2)C(=O)N(C2CCCCC2)c2ccccc21 10.1016/j.bmc.2007.12.047
10257865 215217 4 None -3 5 Rat 7.7 pKi = 7.7 Binding
Tested for binding affinity towards cholecystokinin type B receptor in rat cortex by displacement of [3H]pBC264 radioligandTested for binding affinity towards cholecystokinin type B receptor in rat cortex by displacement of [3H]pBC264 radioligand
ChEMBL 591 10 3 4 5.8 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccc(Cl)cc1)CC(=O)O 10.1021/jm00072a005
CHEMBL99939 215217 4 None -3 5 Rat 7.7 pKi = 7.7 Binding
Tested for binding affinity towards cholecystokinin type B receptor in rat cortex by displacement of [3H]pBC264 radioligandTested for binding affinity towards cholecystokinin type B receptor in rat cortex by displacement of [3H]pBC264 radioligand
ChEMBL 591 10 3 4 5.8 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccc(Cl)cc1)CC(=O)O 10.1021/jm00072a005
90662930 113348 0 None -3981 2 Rat 6.7 pKi = 6.7 Binding
Binding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligand
ChEMBL 1073 29 11 11 2.6 CCCC[C@H](NC(=O)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)NC(=O)c1ccccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm990252e
CHEMBL3142366 113348 0 None -3981 2 Rat 6.7 pKi = 6.7 Binding
Binding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligand
ChEMBL 1073 29 11 11 2.6 CCCC[C@H](NC(=O)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)NC(=O)c1ccccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm990252e
CHEMBL2372623 217056 0 None -218 4 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2010.05.078
11664728 141199 0 None 10 2 Mouse 6.7 pKi = 6.7 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 482 7 3 2 7.1 Cc1ccccc1-c1cc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
CHEMBL371750 141199 0 None 10 2 Mouse 6.7 pKi = 6.7 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 482 7 3 2 7.1 Cc1ccccc1-c1cc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
15024387 122201 0 None - 1 Mouse 5.7 pKi = 5.7 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 515 9 4 4 4.4 O=C(N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1)OC1C2CC3CC(C2)CC1C3 10.1021/jm00087a011
CHEMBL3350393 122201 0 None - 1 Mouse 5.7 pKi = 5.7 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 515 9 4 4 4.4 O=C(N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1)OC1C2CC3CC(C2)CC1C3 10.1021/jm00087a011
15513851 121736 0 None - 1 Mouse 5.7 pKi = 5.7 Binding
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 603 7 2 5 4.3 CC(=O)N1[C@H](C(=O)NCC(=O)O)CC(=O)c2ccccc2N(Cc2ccc(F)cc2)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
CHEMBL334247 121736 0 None - 1 Mouse 5.7 pKi = 5.7 Binding
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 603 7 2 5 4.3 CC(=O)N1[C@H](C(=O)NCC(=O)O)CC(=O)c2ccccc2N(Cc2ccc(F)cc2)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
10258121 105349 0 None -11 2 Human 4.7 pKi = 4.7 Binding
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 606 11 4 2 7.1 CC(Cc1c[nH]c2ccccc12)(NC(=O)NC(c1ccccc1)(c1ccccc1)c1ccccc1)C(=O)NCCc1ccccc1 10.1021/jm00072a005
CHEMBL276676 105349 0 None -11 2 Human 4.7 pKi = 4.7 Binding
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 606 11 4 2 7.1 CC(Cc1c[nH]c2ccccc12)(NC(=O)NC(c1ccccc1)(c1ccccc1)c1ccccc1)C(=O)NCCc1ccccc1 10.1021/jm00072a005
10257865 215217 4 None -2 5 Mouse 7.7 pKi = 7.7 Binding
Tested for binding affinity towards CCK-B in mouse brain by displacement of [3H]-pBC264 radioligandTested for binding affinity towards CCK-B in mouse brain by displacement of [3H]-pBC264 radioligand
ChEMBL 591 10 3 4 5.8 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccc(Cl)cc1)CC(=O)O 10.1021/jm00072a005
CHEMBL99939 215217 4 None -2 5 Mouse 7.7 pKi = 7.7 Binding
Tested for binding affinity towards CCK-B in mouse brain by displacement of [3H]-pBC264 radioligandTested for binding affinity towards CCK-B in mouse brain by displacement of [3H]-pBC264 radioligand
ChEMBL 591 10 3 4 5.8 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccc(Cl)cc1)CC(=O)O 10.1021/jm00072a005
10413618 209570 0 None - 1 Mouse 7.7 pKi = 7.7 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 499 8 3 3 5.4 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 10.1021/jm00087a011
CHEMBL62205 209570 0 None - 1 Mouse 7.7 pKi = 7.7 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 499 8 3 3 5.4 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 10.1021/jm00087a011
44580901 176246 0 None -3 2 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]CCK-26-33 from CCK2R-MOPR coexpressed in CHO cellsDisplacement of [125I]CCK-26-33 from CCK2R-MOPR coexpressed in CHO cells
ChEMBL 843 12 6 11 2.8 CN1C(=O)[C@H](NC(=O)Nc2cccc(OCCNC(=O)COCC(=O)N[C@H]3CC[C@@]4(O)[C@H]5Cc6cc(O)cc7c6[C@@]4(CCN5C)[C@H]3O7)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm800174p
CHEMBL442943 176246 0 None -3 2 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]CCK-26-33 from CCK2R-MOPR coexpressed in CHO cellsDisplacement of [125I]CCK-26-33 from CCK2R-MOPR coexpressed in CHO cells
ChEMBL 843 12 6 11 2.8 CN1C(=O)[C@H](NC(=O)Nc2cccc(OCCNC(=O)COCC(=O)N[C@H]3CC[C@@]4(O)[C@H]5Cc6cc(O)cc7c6[C@@]4(CCN5C)[C@H]3O7)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm800174p
46235271 80423 2 None -2 2 Human 6.7 pKi = 6.7 Binding
Displacement of [125I-CCK] from wild-type human CCK2R at allosteric site expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-CCK] from wild-type human CCK2R at allosteric site expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 649 7 1 6 6.7 Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 10.1021/acs.jmedchem.5b01110
CHEMBL2017835 80423 2 None -2 2 Human 6.7 pKi = 6.7 Binding
Displacement of [125I-CCK] from wild-type human CCK2R at allosteric site expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-CCK] from wild-type human CCK2R at allosteric site expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 649 7 1 6 6.7 Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 10.1021/acs.jmedchem.5b01110
44346826 120591 0 None 69 2 Mouse 6.7 pKi = 6.7 Binding
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 595 7 3 4 3.9 O=C(O)CNC(=O)[C@H]1CCCN1C(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC1C2CC3CC(C2)CC1C3 10.1021/jm00048a001
CHEMBL332510 120591 0 None 69 2 Mouse 6.7 pKi = 6.7 Binding
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 595 7 3 4 3.9 O=C(O)CNC(=O)[C@H]1CCCN1C(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC1C2CC3CC(C2)CC1C3 10.1021/jm00048a001
15513852 17963 0 None - 1 Mouse 6.7 pKi = 6.7 Binding
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 603 7 2 5 4.3 CC(=O)N1[C@H](C(=O)NCC(=O)O)CC(=O)c2ccccc2N(Cc2cccc(F)c2)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
CHEMBL117868 17963 0 None - 1 Mouse 6.7 pKi = 6.7 Binding
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 603 7 2 5 4.3 CC(=O)N1[C@H](C(=O)NCC(=O)O)CC(=O)c2ccccc2N(Cc2cccc(F)c2)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
15513857 121315 0 None - 1 Mouse 5.7 pKi = 5.7 Binding
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 599 7 1 6 4.3 COC(=O)CNC(=O)[C@@H]1CC(=O)c2ccccc2N(Cc2ccccc2)C(=O)[C@@H](CC23CC4CC(CC(C4)C2)C3)N1C(C)=O 10.1021/jm000960w
CHEMBL333623 121315 0 None - 1 Mouse 5.7 pKi = 5.7 Binding
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 599 7 1 6 4.3 COC(=O)CNC(=O)[C@@H]1CC(=O)c2ccccc2N(Cc2ccccc2)C(=O)[C@@H](CC23CC4CC(CC(C4)C2)C3)N1C(C)=O 10.1021/jm000960w
9853654 29561 41 None 31 2 Human 7.7 pKi = 7.7 Binding
The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80686-1
CHEMBL1328 29561 41 None 31 2 Human 7.7 pKi = 7.7 Binding
The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80686-1
CHEMBL3142842 217914 0 None 2 2 Human 5.7 pKi = 5.7 Binding
Apparent affinity to inhibit binding of [3H]pCCK-8 to Cholecystokinin type B receptor of guinea pig brain membranesApparent affinity to inhibit binding of [3H]pCCK-8 to Cholecystokinin type B receptor of guinea pig brain membranes
ChEMBL None None None CC(C)(C)OC(=O)NCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00174a016
10581797 70018 0 None -9120 2 Rat 5.7 pKi = 5.7 Binding
Binding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomesBinding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomes
ChEMBL 976 26 9 11 1.3 CC[C@H](C)[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)[C@@H](C)CC 10.1021/jm970477u
CHEMBL1791002 70018 0 None -9120 2 Rat 5.7 pKi = 5.7 Binding
Binding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomesBinding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomes
ChEMBL 976 26 9 11 1.3 CC[C@H](C)[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)[C@@H](C)CC 10.1021/jm970477u
CHEMBL205306 215947 0 None -109 3 Human 5.7 pKi = 5.7 Binding
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](CCCC)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm050921q
10071178 81270 2 None -501 2 Human 4.7 pKi = 4.7 Binding
Displacement of [125I]BH-(Thr,-Nle)-CCK-9 from human CCK2 receptor expressed in COS-7 cells after 60 mins by gamma countingDisplacement of [125I]BH-(Thr,-Nle)-CCK-9 from human CCK2 receptor expressed in COS-7 cells after 60 mins by gamma counting
ChEMBL 427 7 4 3 3.8 O=C(Nc1ccccc1C(=O)NC(Cc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 10.1021/jm200438b
CHEMBL202861 81270 2 None -501 2 Human 4.7 pKi = 4.7 Binding
Displacement of [125I]BH-(Thr,-Nle)-CCK-9 from human CCK2 receptor expressed in COS-7 cells after 60 mins by gamma countingDisplacement of [125I]BH-(Thr,-Nle)-CCK-9 from human CCK2 receptor expressed in COS-7 cells after 60 mins by gamma counting
ChEMBL 427 7 4 3 3.8 O=C(Nc1ccccc1C(=O)NC(Cc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 10.1021/jm200438b
44580901 176246 0 None -3 2 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]CCK-26-33 from CCK2 receptor expressed in CHO cellsDisplacement of [125I]CCK-26-33 from CCK2 receptor expressed in CHO cells
ChEMBL 843 12 6 11 2.8 CN1C(=O)[C@H](NC(=O)Nc2cccc(OCCNC(=O)COCC(=O)N[C@H]3CC[C@@]4(O)[C@H]5Cc6cc(O)cc7c6[C@@]4(CCN5C)[C@H]3O7)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm800174p
CHEMBL442943 176246 0 None -3 2 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]CCK-26-33 from CCK2 receptor expressed in CHO cellsDisplacement of [125I]CCK-26-33 from CCK2 receptor expressed in CHO cells
ChEMBL 843 12 6 11 2.8 CN1C(=O)[C@H](NC(=O)Nc2cccc(OCCNC(=O)COCC(=O)N[C@H]3CC[C@@]4(O)[C@H]5Cc6cc(O)cc7c6[C@@]4(CCN5C)[C@H]3O7)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm800174p
44332766 115113 0 None -48 2 Human 6.7 pKi = 6.7 Binding
Binding affinity was measured by its ability to displace [3H]CCK-8S from CCK-B receptor in guinea pig brainBinding affinity was measured by its ability to displace [3H]CCK-8S from CCK-B receptor in guinea pig brain
ChEMBL 474 6 2 3 5.1 CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2cc(F)ccc21 10.1016/0960-894X(95)00528-2
CHEMBL319795 115113 0 None -48 2 Human 6.7 pKi = 6.7 Binding
Binding affinity was measured by its ability to displace [3H]CCK-8S from CCK-B receptor in guinea pig brainBinding affinity was measured by its ability to displace [3H]CCK-8S from CCK-B receptor in guinea pig brain
ChEMBL 474 6 2 3 5.1 CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2cc(F)ccc21 10.1016/0960-894X(95)00528-2
10794262 175407 0 None 6 2 Mouse 6.7 pKi = 6.7 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 645 10 4 4 4.8 O=C(O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC12CC3CC(CC(C3)C1)C2 10.1021/jm00021a019
CHEMBL436175 175407 0 None 6 2 Mouse 6.7 pKi = 6.7 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 645 10 4 4 4.8 O=C(O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC12CC3CC(CC(C3)C1)C2 10.1021/jm00021a019
9919500 211704 3 None -7413 2 Rat 6.7 pKi = 6.7 Binding
Binding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomesBinding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomes
ChEMBL 976 28 9 11 1.6 CCCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm970477u
CHEMBL1161142 211704 3 None -7413 2 Rat 6.7 pKi = 6.7 Binding
Binding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomesBinding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomes
ChEMBL 976 28 9 11 1.6 CCCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm970477u
CHEMBL76248 211704 3 None -7413 2 Rat 6.7 pKi = 6.7 Binding
Binding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomesBinding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomes
ChEMBL 976 28 9 11 1.6 CCCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm970477u
9919500 211704 3 None -7413 2 Rat 6.7 pKi = 6.7 Binding
Binding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligand
ChEMBL 976 28 9 11 1.6 CCCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm990252e
CHEMBL1161142 211704 3 None -7413 2 Rat 6.7 pKi = 6.7 Binding
Binding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligand
ChEMBL 976 28 9 11 1.6 CCCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm990252e
CHEMBL76248 211704 3 None -7413 2 Rat 6.7 pKi = 6.7 Binding
Binding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligand
ChEMBL 976 28 9 11 1.6 CCCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm990252e
44329398 214467 0 None 12 2 Human 6.7 pKi = 6.7 Binding
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 543 10 3 4 4.8 O=C(O)CN(CCc1ccccc1)C(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00072a005
CHEMBL95461 214467 0 None 12 2 Human 6.7 pKi = 6.7 Binding
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 543 10 3 4 4.8 O=C(O)CN(CCc1ccccc1)C(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00072a005
CHEMBL332180 218164 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(C)=O 10.1021/jm0000416
10794634 119879 0 None -11220 2 Human 4.6 pKi = 4.6 Binding
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 677 19 7 7 0.3 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(N)=O 10.1021/jm0000416
CHEMBL331394 119879 0 None -11220 2 Human 4.6 pKi = 4.6 Binding
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 677 19 7 7 0.3 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(N)=O 10.1021/jm0000416
73347063 96229 0 None -1 3 Rat 7.6 pKi = 7.6 Binding
Affinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cellsAffinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cells
ChEMBL 674 11 7 6 2.4 C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCCCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm9603072
CHEMBL2371221 96229 0 None -1 3 Rat 7.6 pKi = 7.6 Binding
Affinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cellsAffinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cells
ChEMBL 674 11 7 6 2.4 C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCCCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm9603072
9939572 44265 0 None -21 3 Rat 7.6 pKi = 7.6 Binding
Compound was tested for binding affinity against Cholecystokinin type B receptor in rat cortical membranes using L-365260 as the radioligand.Compound was tested for binding affinity against Cholecystokinin type B receptor in rat cortical membranes using L-365260 as the radioligand.
ChEMBL 662 11 6 5 5.5 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3cc[nH]c3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1016/0960-894X(96)00192-8
CHEMBL14557 44265 0 None -21 3 Rat 7.6 pKi = 7.6 Binding
Compound was tested for binding affinity against Cholecystokinin type B receptor in rat cortical membranes using L-365260 as the radioligand.Compound was tested for binding affinity against Cholecystokinin type B receptor in rat cortical membranes using L-365260 as the radioligand.
ChEMBL 662 11 6 5 5.5 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3cc[nH]c3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1016/0960-894X(96)00192-8
CHEMBL2067949 44265 0 None -21 3 Rat 7.6 pKi = 7.6 Binding
Compound was tested for binding affinity against Cholecystokinin type B receptor in rat cortical membranes using L-365260 as the radioligand.Compound was tested for binding affinity against Cholecystokinin type B receptor in rat cortical membranes using L-365260 as the radioligand.
ChEMBL 662 11 6 5 5.5 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3cc[nH]c3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1016/0960-894X(96)00192-8
44451522 165093 0 None 26 2 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 531 6 1 4 5.1 Cc1cccc(NC(=O)CN2C(=O)N(CC(=O)N3CCCC3)c3ccccc3N(C3CCCCCC3)C2=O)c1 10.1016/j.bmc.2007.12.047
CHEMBL408915 165093 0 None 26 2 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 531 6 1 4 5.1 Cc1cccc(NC(=O)CN2C(=O)N(CC(=O)N3CCCC3)c3ccccc3N(C3CCCCCC3)C2=O)c1 10.1016/j.bmc.2007.12.047
CHEMBL123056 215425 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC 10.1021/jm0000416
16732442 92269 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 504 7 2 5 4.8 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL227097 92269 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 504 7 2 5 4.8 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCC2)c2ccccc21 10.1021/jm070139l
16731711 92294 0 None 15 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 570 7 2 5 5.8 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C23CC4CC(CC(C4)C2)C3)c2ccccc21 10.1021/jm070139l
CHEMBL227369 92294 0 None 15 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 570 7 2 5 5.8 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C23CC4CC(CC(C4)C2)C3)c2ccccc21 10.1021/jm070139l
10390666 215084 0 None 17 2 Human 6.6 pKi = 6.6 Binding
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 485 7 3 3 5.3 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCc1ccccc1 10.1021/jm00072a005
CHEMBL99076 215084 0 None 17 2 Human 6.6 pKi = 6.6 Binding
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 485 7 3 3 5.3 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCc1ccccc1 10.1021/jm00072a005
11567687 142715 0 None -1 2 Mouse 5.6 pKi = 5.6 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 407 6 3 3 4.8 Cc1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
CHEMBL373125 142715 0 None -1 2 Mouse 5.6 pKi = 5.6 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 407 6 3 3 4.8 Cc1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
11801718 106583 0 None - 1 Rat 7.6 pKi = 7.6 Binding
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 599 9 3 5 5.3 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1C[C@H](OCc2ccccc2)C[C@@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
CHEMBL285419 106583 0 None - 1 Rat 7.6 pKi = 7.6 Binding
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 599 9 3 5 5.3 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1C[C@H](OCc2ccccc2)C[C@@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
44351519 175298 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.
ChEMBL 620 8 3 6 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(Cl)cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL435404 175298 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.
ChEMBL 620 8 3 6 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(Cl)cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
44351492 124703 0 None - 1 Human 7.6 pKi = 7.6 Binding
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 600 9 3 6 4.6 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](OCc2ccccc2)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL340327 124703 0 None - 1 Human 7.6 pKi = 7.6 Binding
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 600 9 3 6 4.6 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](OCc2ccccc2)C[C@@H]1C(=O)O 10.1021/jm970439a
44351519 175298 0 None -1 2 Rat 7.6 pKi = 7.6 Binding
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 620 8 3 6 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(Cl)cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL435404 175298 0 None -1 2 Rat 7.6 pKi = 7.6 Binding
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 620 8 3 6 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(Cl)cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
52949124 7663 4 None 2 2 Human 7.6 pKi = 7.6 Binding
Displacement of [125I-BDZ-2] from wild-type human CCK2R at allosteric site expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-BDZ-2] from wild-type human CCK2R at allosteric site expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
9055 7663 4 None 2 2 Human 7.6 pKi = 7.6 Binding
Displacement of [125I-BDZ-2] from wild-type human CCK2R at allosteric site expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-BDZ-2] from wild-type human CCK2R at allosteric site expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
CHEMBL1269258 7663 4 None 2 2 Human 7.6 pKi = 7.6 Binding
Displacement of [125I-BDZ-2] from wild-type human CCK2R at allosteric site expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-BDZ-2] from wild-type human CCK2R at allosteric site expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
DB12694 7663 4 None 2 2 Human 7.6 pKi = 7.6 Binding
Displacement of [125I-BDZ-2] from wild-type human CCK2R at allosteric site expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-BDZ-2] from wild-type human CCK2R at allosteric site expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
904 9800 10 None - 1 Mouse 6.6 pKi = 6.6 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1021/jm00087a011
9915756 9800 10 None - 1 Mouse 6.6 pKi = 6.6 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1021/jm00087a011
CHEMBL2111204 9800 10 None - 1 Mouse 6.6 pKi = 6.6 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1021/jm00087a011
CHEMBL356898 9800 10 None - 1 Mouse 6.6 pKi = 6.6 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1021/jm00087a011
10580492 21308 0 None - 1 Human 5.6 pKi = 5.6 Binding
Compound was tested for binding affinity against Cholecystokinin type B receptor on guinea pig cortex in experiment 1Compound was tested for binding affinity against Cholecystokinin type B receptor on guinea pig cortex in experiment 1
ChEMBL 690 19 7 7 1.0 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)/C=C/C(=O)O 10.1021/jm0000416
CHEMBL120257 21308 0 None - 1 Human 5.6 pKi = 5.6 Binding
Compound was tested for binding affinity against Cholecystokinin type B receptor on guinea pig cortex in experiment 1Compound was tested for binding affinity against Cholecystokinin type B receptor on guinea pig cortex in experiment 1
ChEMBL 690 19 7 7 1.0 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)/C=C/C(=O)O 10.1021/jm0000416
10507109 116004 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity at human CCK2 receptorBinding affinity at human CCK2 receptor
ChEMBL 561 7 2 4 5.3 CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1016/j.bmc.2007.12.047
CHEMBL321761 116004 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity at human CCK2 receptorBinding affinity at human CCK2 receptor
ChEMBL 561 7 2 4 5.3 CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1016/j.bmc.2007.12.047
11540160 78223 0 None -5 3 Mouse 7.6 pKi = 7.6 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 475 7 3 3 6.6 O=C(O)c1cccc(NC(=O)c2[nH]c(C3CCCCC3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
CHEMBL196133 78223 0 None -5 3 Mouse 7.6 pKi = 7.6 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 475 7 3 3 6.6 O=C(O)c1cccc(NC(=O)c2[nH]c(C3CCCCC3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
11693225 205580 0 None 7 2 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation counting
ChEMBL 676 8 3 7 4.8 O=C(N[C@@H](Cc1ccc(Cl)c(Cl)c1)C(=O)O)c1ccc(I)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.065
CHEMBL583344 205580 0 None 7 2 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation counting
ChEMBL 676 8 3 7 4.8 O=C(N[C@@H](Cc1ccc(Cl)c(Cl)c1)C(=O)O)c1ccc(I)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.065
9913081 89206 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 480 4 1 6 3.9 O=C(c1ccc(Br)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1016/j.bmcl.2007.09.087
CHEMBL217453 89206 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 480 4 1 6 3.9 O=C(c1ccc(Br)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1016/j.bmcl.2007.09.087
9913081 89206 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 480 4 1 6 3.9 O=C(c1ccc(Br)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
CHEMBL217453 89206 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 480 4 1 6 3.9 O=C(c1ccc(Br)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
9913081 89206 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]CCK8S from human CCK2RDisplacement of [125I]CCK8S from human CCK2R
ChEMBL 480 4 1 6 3.9 O=C(c1ccc(Br)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1016/j.bmc.2008.01.059
CHEMBL217453 89206 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]CCK8S from human CCK2RDisplacement of [125I]CCK8S from human CCK2R
ChEMBL 480 4 1 6 3.9 O=C(c1ccc(Br)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1016/j.bmc.2008.01.059
44403980 18577 0 None 398 2 Mouse 7.6 pKi = 7.6 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 677 11 5 6 5.2 CN(C(=O)c1cc2[nH]cnc2cc1C(=O)NCC12CC3CC(CC(C3)C1)C2)[C@@H](Cc1ccccc1)C(=O)Nc1cc(C(=O)O)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL1181938 18577 0 None 398 2 Mouse 7.6 pKi = 7.6 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 677 11 5 6 5.2 CN(C(=O)c1cc2[nH]cnc2cc1C(=O)NCC12CC3CC(CC(C3)C1)C2)[C@@H](Cc1ccccc1)C(=O)Nc1cc(C(=O)O)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL2067951 18577 0 None 398 2 Mouse 7.6 pKi = 7.6 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 677 11 5 6 5.2 CN(C(=O)c1cc2[nH]cnc2cc1C(=O)NCC12CC3CC(CC(C3)C1)C2)[C@@H](Cc1ccccc1)C(=O)Nc1cc(C(=O)O)cc(C(=O)O)c1 10.1021/jm049069y
121964 6995 34 None -831 2 Rat 6.6 pKi = 6.6 Binding
Binding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligand
ChEMBL None None None None 10.1021/jm990252e
858 6995 34 None -831 2 Rat 6.6 pKi = 6.6 Binding
Binding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligand
ChEMBL None None None None 10.1021/jm990252e
CHEMBL323521 6995 34 None -831 2 Rat 6.6 pKi = 6.6 Binding
Binding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligand
ChEMBL None None None None 10.1021/jm990252e
45486947 203681 0 None -1 2 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation counting
ChEMBL 654 8 2 7 5.2 COC(=O)[C@H](Cc1ccc(F)c(Br)c1)NC(=O)c1cc(Cl)c(Cl)cc1NS(=O)(=O)c1cccc2nccnc12 10.1016/j.bmcl.2009.09.065
CHEMBL566177 203681 0 None -1 2 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation counting
ChEMBL 654 8 2 7 5.2 COC(=O)[C@H](Cc1ccc(F)c(Br)c1)NC(=O)c1cc(Cl)c(Cl)cc1NS(=O)(=O)c1cccc2nccnc12 10.1016/j.bmcl.2009.09.065
11396307 143321 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 430 5 1 6 3.7 CCc1ccc(C(=O)N2CCCCC2)c(NS(=O)(=O)c2cccc3nsnc23)c1 10.1021/jm060590x
CHEMBL373703 143321 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 430 5 1 6 3.7 CCc1ccc(C(=O)N2CCCCC2)c(NS(=O)(=O)c2cccc3nsnc23)c1 10.1021/jm060590x
11281656 148560 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 422 4 1 6 3.4 O=C(c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCC1 10.1021/jm060590x
CHEMBL386143 148560 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 422 4 1 6 3.4 O=C(c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCC1 10.1021/jm060590x
11518254 18573 0 None 31 2 Mouse 6.6 pKi = 6.6 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 460 7 4 3 5.8 O=C(O)c1cc(NC(=O)c2cc(-c3ccccc3)[nH]c2CC2CCCCCC2)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL1181918 18573 0 None 31 2 Mouse 6.6 pKi = 6.6 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 460 7 4 3 5.8 O=C(O)c1cc(NC(=O)c2cc(-c3ccccc3)[nH]c2CC2CCCCCC2)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL2067948 18573 0 None 31 2 Mouse 6.6 pKi = 6.6 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 460 7 4 3 5.8 O=C(O)c1cc(NC(=O)c2cc(-c3ccccc3)[nH]c2CC2CCCCCC2)cc(C(=O)O)c1 10.1021/jm049069y
9958028 18576 0 None 12 2 Mouse 6.6 pKi = 6.6 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 511 7 4 4 6.4 O=C(O)c1cc(NC(=O)c2[nH]c(-c3ccc4ccccc4c3)nc2CC2CCCCCC2)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL1181937 18576 0 None 12 2 Mouse 6.6 pKi = 6.6 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 511 7 4 4 6.4 O=C(O)c1cc(NC(=O)c2[nH]c(-c3ccc4ccccc4c3)nc2CC2CCCCCC2)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL2067950 18576 0 None 12 2 Mouse 6.6 pKi = 6.6 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 511 7 4 4 6.4 O=C(O)c1cc(NC(=O)c2[nH]c(-c3ccc4ccccc4c3)nc2CC2CCCCCC2)cc(C(=O)O)c1 10.1021/jm049069y
16090692 89215 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 458 6 2 6 4.1 O=C(NCc1ccccc1)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.064
CHEMBL217492 89215 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 458 6 2 6 4.1 O=C(NCc1ccccc1)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.064
11699148 82756 0 None -2 2 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 511 7 2 6 3.4 CNc1cccc(NC(=O)CN2N=C(c3ccccn3)c3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 10.1021/jm051219x
CHEMBL205423 82756 0 None -2 2 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 511 7 2 6 3.4 CNc1cccc(NC(=O)CN2N=C(c3ccccn3)c3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 10.1021/jm051219x
25033229 161280 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 494 4 1 5 4.0 O=C(c1ccc(Br)cc1NS(=O)(=O)c1ccc2c(c1)OCCCO2)N1CCCCC1 10.1016/j.bmcl.2007.09.087
CHEMBL399059 161280 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 494 4 1 5 4.0 O=C(c1ccc(Br)cc1NS(=O)(=O)c1ccc2c(c1)OCCCO2)N1CCCCC1 10.1016/j.bmcl.2007.09.087
16090650 87835 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 451 4 1 7 2.5 CN1CCN(C(=O)c2ccc(Cl)cc2NS(=O)(=O)c2cccc3nsnc23)CC1 10.1021/jm060590x
CHEMBL215415 87835 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 451 4 1 7 2.5 CN1CCN(C(=O)c2ccc(Cl)cc2NS(=O)(=O)c2cccc3nsnc23)CC1 10.1021/jm060590x
16090791 88893 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 462 6 1 8 3.1 COc1cc(NS(=O)(=O)c2cccc3nsnc23)c(C(=O)N2CCCCC2)cc1OC 10.1021/jm060590x
CHEMBL216623 88893 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 462 6 1 8 3.1 COc1cc(NS(=O)(=O)c2cccc3nsnc23)c(C(=O)N2CCCCC2)cc1OC 10.1021/jm060590x
16090692 89215 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 458 6 2 6 4.1 O=C(NCc1ccccc1)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1021/jm060590x
CHEMBL217492 89215 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 458 6 2 6 4.1 O=C(NCc1ccccc1)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1021/jm060590x
15297878 119871 0 None - 1 Mouse 5.6 pKi = 5.6 Binding
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 433 4 2 2 5.1 O=C(O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCc1cccc2ccccc12 10.1021/jm00048a001
CHEMBL331324 119871 0 None - 1 Mouse 5.6 pKi = 5.6 Binding
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 433 4 2 2 5.1 O=C(O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCc1cccc2ccccc12 10.1021/jm00048a001
CHEMBL382051 219072 0 None -131 4 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm050921q
44351455 123597 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 604 8 3 6 4.6 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(F)cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL337934 123597 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 604 8 3 6 4.6 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(F)cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
44351446 162920 0 None 3 2 Human 7.6 pKi = 7.6 Binding
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 631 9 3 8 4.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc([N+](=O)[O-])cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL406359 162920 0 None 3 2 Human 7.6 pKi = 7.6 Binding
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 631 9 3 8 4.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc([N+](=O)[O-])cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
11613179 78563 0 None -3 3 Mouse 7.6 pKi = 7.6 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 511 7 3 3 7.1 Cc1cc(C)c(-c2nc(C(=O)Nc3cccc(C(=O)O)c3)c(CCC34CC5CC(CC(C5)C3)C4)[nH]2)c(C)c1 10.1021/jm0490686
CHEMBL196745 78563 0 None -3 3 Mouse 7.6 pKi = 7.6 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 511 7 3 3 7.1 Cc1cc(C)c(-c2nc(C(=O)Nc3cccc(C(=O)O)c3)c(CCC34CC5CC(CC(C5)C3)C4)[nH]2)c(C)c1 10.1021/jm0490686
11576771 81206 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 489 6 2 5 5.0 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(N)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
CHEMBL202680 81206 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 489 6 2 5 5.0 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(N)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
44580900 195219 0 None -2 2 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]CCK-26-33 from CCK2 receptor expressed in CHO cellsDisplacement of [125I]CCK-26-33 from CCK2 receptor expressed in CHO cells
ChEMBL 1057 23 8 14 2.6 CN1C(=O)[C@H](NC(=O)Nc2cccc(OCCNC(=O)COCC(=O)NCCCCCCNC(=O)COCC(=O)N[C@H]3CC[C@@]4(O)[C@H]5Cc6cc(O)cc7c6[C@@]4(CCN5C)[C@H]3O7)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm800174p
CHEMBL502398 195219 0 None -2 2 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]CCK-26-33 from CCK2 receptor expressed in CHO cellsDisplacement of [125I]CCK-26-33 from CCK2 receptor expressed in CHO cells
ChEMBL 1057 23 8 14 2.6 CN1C(=O)[C@H](NC(=O)Nc2cccc(OCCNC(=O)COCC(=O)NCCCCCCNC(=O)COCC(=O)N[C@H]3CC[C@@]4(O)[C@H]5Cc6cc(O)cc7c6[C@@]4(CCN5C)[C@H]3O7)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm800174p
15513860 120094 0 None - 1 Mouse 5.6 pKi = 5.6 Binding
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 602 8 1 5 5.6 CC(=O)N1[C@H](C(=O)CCC(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2F)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
CHEMBL331560 120094 0 None - 1 Mouse 5.6 pKi = 5.6 Binding
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 602 8 1 5 5.6 CC(=O)N1[C@H](C(=O)CCC(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2F)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
11698512 175034 0 None -5 3 Mouse 6.6 pKi = 6.6 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 435 8 3 3 5.5 CCCc1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
CHEMBL433776 175034 0 None -5 3 Mouse 6.6 pKi = 6.6 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 435 8 3 3 5.5 CCCc1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
108187 7713 37 None -295 5 Rat 6.6 pKi = 6.6 Binding
Inhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of rat pancreatic membranesInhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of rat pancreatic membranes
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm990967h
873 7713 37 None -295 5 Rat 6.6 pKi = 6.6 Binding
Inhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of rat pancreatic membranesInhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of rat pancreatic membranes
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm990967h
CHEMBL2062154 7713 37 None -295 5 Rat 6.6 pKi = 6.6 Binding
Inhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of rat pancreatic membranesInhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of rat pancreatic membranes
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm990967h
CHEMBL287735 7713 37 None -295 5 Rat 6.6 pKi = 6.6 Binding
Inhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of rat pancreatic membranesInhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of rat pancreatic membranes
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm990967h
5311201 214174 35 None -234 6 Rat 6.6 pKi = 6.6 Binding
Inhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of rat pancreatic membranesInhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of rat pancreatic membranes
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm990967h
CHEMBL9387 214174 35 None -234 6 Rat 6.6 pKi = 6.6 Binding
Inhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of rat pancreatic membranesInhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of rat pancreatic membranes
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm990967h
443375 214385 45 None -389 5 Rat 6.6 pKi = 6.6 Binding
Inhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of rat pancreatic membranesInhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of rat pancreatic membranes
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm990967h
CHEMBL9506 214385 45 None -389 5 Rat 6.6 pKi = 6.6 Binding
Inhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of rat pancreatic membranesInhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of rat pancreatic membranes
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm990967h
11505466 78805 0 None -2 2 Mouse 5.6 pKi = 5.6 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 425 7 3 3 5.1 Cc1ccccc1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCc2ccccc2)[nH]1 10.1021/jm0490686
CHEMBL197578 78805 0 None -2 2 Mouse 5.6 pKi = 5.6 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 425 7 3 3 5.1 Cc1ccccc1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCc2ccccc2)[nH]1 10.1021/jm0490686
10840341 19278 0 None - 1 Mouse 5.6 pKi = 5.6 Binding
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 547 7 2 5 4.0 CC(=O)N1[C@H](C(=O)NCC(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2)C(=O)[C@H]1CC1CCCCCC1 10.1021/jm000960w
CHEMBL118653 19278 0 None - 1 Mouse 5.6 pKi = 5.6 Binding
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 547 7 2 5 4.0 CC(=O)N1[C@H](C(=O)NCC(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2)C(=O)[C@H]1CC1CCCCCC1 10.1021/jm000960w
10099495 114510 0 None 117 2 Human 7.6 pKi = 7.6 Binding
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 567 8 3 3 6.7 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccc(Cl)cc1Cl 10.1021/jm00072a005
CHEMBL319120 114510 0 None 117 2 Human 7.6 pKi = 7.6 Binding
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 567 8 3 3 6.7 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccc(Cl)cc1Cl 10.1021/jm00072a005
44272156 148320 0 None 45 2 Human 7.6 pKi = 7.6 Binding
Displacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranesDisplacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranes
ChEMBL 1194 24 13 13 2.6 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00126a007
CHEMBL384731 148320 0 None 45 2 Human 7.6 pKi = 7.6 Binding
Displacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranesDisplacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranes
ChEMBL 1194 24 13 13 2.6 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00126a007
11498528 79251 0 None -38 3 Mouse 7.6 pKi = 7.6 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 503 7 3 4 6.1 O=C(O)c1cccc(NC(=O)c2[nH]c(C34CCC(CC3)CC4)nc2COC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
CHEMBL198933 79251 0 None -38 3 Mouse 7.6 pKi = 7.6 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 503 7 3 4 6.1 O=C(O)c1cccc(NC(=O)c2[nH]c(C34CCC(CC3)CC4)nc2COC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
CHEMBL383458 219092 0 None -4 4 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm050921q
10840582 174758 0 None -257 2 Rat 5.6 pKi = 5.6 Binding
Inhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranesInhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranes
ChEMBL 559 7 3 5 4.1 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@H]12 10.1021/jm9703247
CHEMBL431858 174758 0 None -257 2 Rat 5.6 pKi = 5.6 Binding
Inhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranesInhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranes
ChEMBL 559 7 3 5 4.1 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@H]12 10.1021/jm9703247
10698558 123999 0 None 3 2 Rat 7.6 pKi = 7.6 Binding
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 585 8 3 5 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccccc2)C[C@@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
CHEMBL339451 123999 0 None 3 2 Rat 7.6 pKi = 7.6 Binding
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 585 8 3 5 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccccc2)C[C@@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
10579208 125164 0 None - 1 Human 7.6 pKi = 7.6 Binding
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 585 8 3 5 5.2 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccccc2)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL341045 125164 0 None - 1 Human 7.6 pKi = 7.6 Binding
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 585 8 3 5 5.2 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccccc2)C[C@@H]1C(=O)O 10.1021/jm970439a
44329798 114326 0 None -2 5 Rat 7.6 pKi = 7.6 Binding
Tested for binding affinity towards cholecystokinin type B receptor in rat pancreas by displacement of [3H]pCCK-8 radioligandTested for binding affinity towards cholecystokinin type B receptor in rat pancreas by displacement of [3H]pCCK-8 radioligand
ChEMBL 610 10 2 4 6.5 CC(Cc1c[nH]c2ccccc12)(C(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccc(Cl)cc1Cl)CC(=O)O 10.1021/jm00072a005
CHEMBL318852 114326 0 None -2 5 Rat 7.6 pKi = 7.6 Binding
Tested for binding affinity towards cholecystokinin type B receptor in rat pancreas by displacement of [3H]pCCK-8 radioligandTested for binding affinity towards cholecystokinin type B receptor in rat pancreas by displacement of [3H]pCCK-8 radioligand
ChEMBL 610 10 2 4 6.5 CC(Cc1c[nH]c2ccccc12)(C(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccc(Cl)cc1Cl)CC(=O)O 10.1021/jm00072a005
44356886 35200 0 None 42 2 Mouse 7.6 pKi = 7.6 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 757 11 5 5 7.3 O=C(O)c1cc(NC(=O)[C@@H](CC2CCCCC2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm00021a019
CHEMBL137525 35200 0 None 42 2 Mouse 7.6 pKi = 7.6 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 757 11 5 5 7.3 O=C(O)c1cc(NC(=O)[C@@H](CC2CCCCC2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm00021a019
44331479 11144 0 None 27 2 Human 7.5 pKi = 7.5 Binding
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 494 9 1 5 4.7 CC(C)CCN1C(=O)C(NC(=O)Oc2cccc(N(C)C)c2)C(=O)N(CCC(C)C)c2ccccc21 10.1016/S0960-894X(96)00544-6
CHEMBL101208 11144 0 None 27 2 Human 7.5 pKi = 7.5 Binding
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 494 9 1 5 4.7 CC(C)CCN1C(=O)C(NC(=O)Oc2cccc(N(C)C)c2)C(=O)N(CCC(C)C)c2ccccc21 10.1016/S0960-894X(96)00544-6
10793450 124251 0 None - 1 Human 6.5 pKi = 6.5 Binding
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 585 8 3 5 5.2 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccccc2)C[C@H]1C(=O)O 10.1021/jm970439a
CHEMBL339931 124251 0 None - 1 Human 6.5 pKi = 6.5 Binding
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 585 8 3 5 5.2 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccccc2)C[C@H]1C(=O)O 10.1021/jm970439a
11512112 82367 0 None -5 2 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 532 8 2 6 4.9 CNc1cccc(NC(=O)CN2N=C(c3ccccn3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1 10.1021/jm051219x
CHEMBL204683 82367 0 None -5 2 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 532 8 2 6 4.9 CNc1cccc(NC(=O)CN2N=C(c3ccccn3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1 10.1021/jm051219x
10618720 200570 0 None 4 2 Mouse 5.5 pKi = 5.5 Binding
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 363 4 2 2 4.5 O=C(O)c1cc2ccccc2cc1C(=O)NCC12CC3CC(CC(C3)C1)C2 10.1021/jm9508907
CHEMBL52740 200570 0 None 4 2 Mouse 5.5 pKi = 5.5 Binding
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 363 4 2 2 4.5 O=C(O)c1cc2ccccc2cc1C(=O)NCC12CC3CC(CC(C3)C1)C2 10.1021/jm9508907
44272042 103821 0 None 131 2 Human 7.5 pKi = 7.5 Binding
Displacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranesDisplacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranes
ChEMBL 1274 26 13 15 2.1 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCCNC(=O)CC[C@@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc2ccc(OS(=O)(=O)O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00126a007
CHEMBL266990 103821 0 None 131 2 Human 7.5 pKi = 7.5 Binding
Displacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranesDisplacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranes
ChEMBL 1274 26 13 15 2.1 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCCNC(=O)CC[C@@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc2ccc(OS(=O)(=O)O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00126a007
11584903 147517 0 None 3 3 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 560 10 2 6 5.1 CNCCN(C)c1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
CHEMBL381805 147517 0 None 3 3 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 560 10 2 6 5.1 CNCCN(C)c1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
443375 214385 45 None -316 5 Human 7.5 pKi = 7.5 Binding
Inhibition by displacing [3H]CCK-8S against human Cholecystokinin type B receptorInhibition by displacing [3H]CCK-8S against human Cholecystokinin type B receptor
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm990967h
CHEMBL9506 214385 45 None -316 5 Human 7.5 pKi = 7.5 Binding
Inhibition by displacing [3H]CCK-8S against human Cholecystokinin type B receptorInhibition by displacing [3H]CCK-8S against human Cholecystokinin type B receptor
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm990967h
CHEMBL2370441 216630 0 None 2 2 Human 6.5 pKi = 6.5 Binding
Apparent affinity to inhibit binding of [3H]pCCK-8 to Cholecystokinin type B receptor of guinea pig brain membranesApparent affinity to inhibit binding of [3H]pCCK-8 to Cholecystokinin type B receptor of guinea pig brain membranes
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00174a016
5311188 16577 2 None 1 2 Rat 5.5 pKi = 5.5 Binding
Inhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranesInhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranes
ChEMBL 559 7 3 5 4.1 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@@H]12 10.1021/jm9703247
CHEMBL113718 16577 2 None 1 2 Rat 5.5 pKi = 5.5 Binding
Inhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranesInhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranes
ChEMBL 559 7 3 5 4.1 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@@H]12 10.1021/jm9703247
11497371 77405 0 None 1 3 Mouse 8.5 pKi = 8.5 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 525 7 3 3 7.4 Cc1cc(C)c(-c2nc(C(=O)Nc3ccc(C)c(C(=O)O)c3)c(CCC34CC5CC(CC(C5)C3)C4)[nH]2)c(C)c1 10.1021/jm0490686
CHEMBL195007 77405 0 None 1 3 Mouse 8.5 pKi = 8.5 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 525 7 3 3 7.4 Cc1cc(C)c(-c2nc(C(=O)Nc3ccc(C)c(C(=O)O)c3)c(CCC34CC5CC(CC(C5)C3)C4)[nH]2)c(C)c1 10.1021/jm0490686
9939183 120905 0 None 6606 2 Human 8.5 pKi = 8.5 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 633 7 2 5 5.9 O=C(Nc1cccc(CN2CCOCC2)c1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
CHEMBL332850 120905 0 None 6606 2 Human 8.5 pKi = 8.5 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 633 7 2 5 5.9 O=C(Nc1cccc(CN2CCOCC2)c1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
44451843 166218 0 None 13 3 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 562 8 2 5 5.5 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CC(=O)O)c2)C(=O)N(C2CCCCCC2)c2ccccc21 10.1016/j.bmc.2007.12.047
CHEMBL410114 166218 0 None 13 3 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 562 8 2 5 5.5 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CC(=O)O)c2)C(=O)N(C2CCCCCC2)c2ccccc21 10.1016/j.bmc.2007.12.047
CHEMBL3350335 218253 0 None 245 2 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C 10.1021/jm00053a022
44357057 125998 0 None 446 2 Mouse 8.5 pKi = 8.5 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 769 11 5 5 6.7 O=C(O)c1cc(NC(=O)[C@@H](Cc2ccccc2F)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm00021a019
CHEMBL343367 125998 0 None 446 2 Mouse 8.5 pKi = 8.5 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 769 11 5 5 6.7 O=C(O)c1cc(NC(=O)[C@@H](Cc2ccccc2F)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm00021a019
11555184 172811 0 None -3 3 Mouse 8.5 pKi = 8.5 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 503 7 3 3 7.0 Cc1ccc(NC(=O)c2[nH]c(C3(C)CCCCC3)nc2CCC23CC4CC(CC(C4)C2)C3)cc1C(=O)O 10.1021/jm0490686
CHEMBL425574 172811 0 None -3 3 Mouse 8.5 pKi = 8.5 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 503 7 3 3 7.0 Cc1ccc(NC(=O)c2[nH]c(C3(C)CCCCC3)nc2CCC23CC4CC(CC(C4)C2)C3)cc1C(=O)O 10.1021/jm0490686
44346176 120111 0 None 21 2 Human 8.5 pKi = 8.5 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 496 6 3 3 6.2 CC(CC1CCCC1)c1cccc2c1NC(=O)C(NC(=O)Nc1ccccc1)C(=O)N2c1ccccc1 10.1021/jm990967h
CHEMBL331651 120111 0 None 21 2 Human 8.5 pKi = 8.5 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 496 6 3 3 6.2 CC(CC1CCCC1)c1cccc2c1NC(=O)C(NC(=O)Nc1ccccc1)C(=O)N2c1ccccc1 10.1021/jm990967h
10628422 115950 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 692 19 6 8 0.9 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(=O)OC 10.1021/jm0000416
CHEMBL321456 115950 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 692 19 6 8 0.9 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(=O)OC 10.1021/jm0000416
443375 214385 45 None -316 5 Human 8.4 pKi = 8.4 Binding
Binding affinity against Cholecystokinin type B receptor using [3H](MeNLE28,31)-CCK-8 as radioligand in guinea pig cerebral cortex.Binding affinity against Cholecystokinin type B receptor using [3H](MeNLE28,31)-CCK-8 as radioligand in guinea pig cerebral cortex.
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm950423p
CHEMBL9506 214385 45 None -316 5 Human 8.4 pKi = 8.4 Binding
Binding affinity against Cholecystokinin type B receptor using [3H](MeNLE28,31)-CCK-8 as radioligand in guinea pig cerebral cortex.Binding affinity against Cholecystokinin type B receptor using [3H](MeNLE28,31)-CCK-8 as radioligand in guinea pig cerebral cortex.
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm950423p
118727698 124369 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of Eu-DTPA-PEGO-CCK4 from human cholecystokinin 2 receptor overexpressed in HEK-293 cells co-expressing human MC4R after 1 hr by time resolved fluorescence-based competition binding assayDisplacement of Eu-DTPA-PEGO-CCK4 from human cholecystokinin 2 receptor overexpressed in HEK-293 cells co-expressing human MC4R after 1 hr by time resolved fluorescence-based competition binding assay
ChEMBL 2392 78 21 30 7.0 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCCn1cc(COc2cc(OCc3cn(CCCCCC(=O)N[C@@H](Cc4c[nH]c5ccccc45)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc4ccccc4)C(N)=O)nn3)cc(OCc3cn(CCCCCC(=O)N[C@@H](Cc4c[nH]c5ccccc45)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc4ccccc4)C(N)=O)nn3)c2)nn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmc.2015.02.028
CHEMBL3400296 124369 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of Eu-DTPA-PEGO-CCK4 from human cholecystokinin 2 receptor overexpressed in HEK-293 cells co-expressing human MC4R after 1 hr by time resolved fluorescence-based competition binding assayDisplacement of Eu-DTPA-PEGO-CCK4 from human cholecystokinin 2 receptor overexpressed in HEK-293 cells co-expressing human MC4R after 1 hr by time resolved fluorescence-based competition binding assay
ChEMBL 2392 78 21 30 7.0 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCCn1cc(COc2cc(OCc3cn(CCCCCC(=O)N[C@@H](Cc4c[nH]c5ccccc45)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc4ccccc4)C(N)=O)nn3)cc(OCc3cn(CCCCCC(=O)N[C@@H](Cc4c[nH]c5ccccc45)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc4ccccc4)C(N)=O)nn3)c2)nn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmc.2015.02.028
10076872 122250 0 None - 1 Mouse 8.4 pKi = 8.4 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 576 12 5 5 4.6 C[C@@H]1CCCC[C@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1 10.1021/jm00087a011
CHEMBL3351018 122250 0 None - 1 Mouse 8.4 pKi = 8.4 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 576 12 5 5 4.6 C[C@@H]1CCCC[C@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1 10.1021/jm00087a011
5311201 214174 35 None -26 6 Mouse 8.4 pKi = 8.4 Binding
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00048a001
CHEMBL9387 214174 35 None -26 6 Mouse 8.4 pKi = 8.4 Binding
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00048a001
CHEMBL408330 219484 0 None -1 3 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](CCCC)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
44345946 21545 0 None - 1 Human 8.4 pKi = 8.4 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 636 10 3 5 6.3 O=C(O)CCCOc1ccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)cc1 10.1021/jm990967h
CHEMBL120657 21545 0 None - 1 Human 8.4 pKi = 8.4 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 636 10 3 5 6.3 O=C(O)CCCOc1ccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)cc1 10.1021/jm990967h
10722460 21964 0 None 309 2 Human 8.4 pKi = 8.4 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 612 5 2 3 6.9 O=C(Nc1cccc(Br)c1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
CHEMBL121028 21964 0 None 309 2 Human 8.4 pKi = 8.4 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 612 5 2 3 6.9 O=C(Nc1cccc(Br)c1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
10532528 21322 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 676 19 6 7 1.4 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(C)=O 10.1021/jm0000416
CHEMBL120335 21322 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 676 19 6 7 1.4 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(C)=O 10.1021/jm0000416
10370877 122253 0 None - 1 Mouse 8.4 pKi = 8.4 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 574 11 5 5 4.4 C[C@@H]1CCCC[C@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)NC[C@H](NC(=O)/C=C/C(=O)O)c1ccccc1 10.1021/jm00087a011
CHEMBL3351021 122253 0 None - 1 Mouse 8.4 pKi = 8.4 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 574 11 5 5 4.4 C[C@@H]1CCCC[C@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)NC[C@H](NC(=O)/C=C/C(=O)O)c1ccccc1 10.1021/jm00087a011
16733051 143734 0 None 758 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 595 8 2 7 4.2 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)NS(C)(=O)=O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL374390 143734 0 None 758 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 595 8 2 7 4.2 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)NS(C)(=O)=O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
44331468 11059 0 None 16 2 Human 8.4 pKi = 8.4 Binding
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 470 7 2 3 4.8 CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(Cc2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00544-6
CHEMBL100685 11059 0 None 16 2 Human 8.4 pKi = 8.4 Binding
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 470 7 2 3 4.8 CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(Cc2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00544-6
10580503 108467 0 None 234 2 Mouse 8.4 pKi = 8.4 Binding
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 691 11 6 10 3.7 O=C(NCC1CCCCCC1)c1cc2nc[nH]c2cc1C(=O)N[C@@H](Cc1ccccc1F)C(=O)Nc1cc(-c2nn[nH]n2)cc(-c2nn[nH]n2)c1 10.1021/jm9508907
CHEMBL299387 108467 0 None 234 2 Mouse 8.4 pKi = 8.4 Binding
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 691 11 6 10 3.7 O=C(NCC1CCCCCC1)c1cc2nc[nH]c2cc1C(=O)N[C@@H](Cc1ccccc1F)C(=O)Nc1cc(-c2nn[nH]n2)cc(-c2nn[nH]n2)c1 10.1021/jm9508907
44580898 195141 0 None -5 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]DAMGO from CCK2R-MOPR coexpressed in CHO cellsDisplacement of [3H]DAMGO from CCK2R-MOPR coexpressed in CHO cells
ChEMBL 973 16 8 14 1.0 CN1C(=O)[C@H](NC(=O)Nc2cccc(OCCNC(=O)COCC(=O)NNC(=O)COCC(=O)N[C@H]3CC[C@@]4(O)[C@H]5Cc6cc(O)cc7c6[C@@]4(CCN5C)[C@H]3O7)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm800174p
CHEMBL501238 195141 0 None -5 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]DAMGO from CCK2R-MOPR coexpressed in CHO cellsDisplacement of [3H]DAMGO from CCK2R-MOPR coexpressed in CHO cells
ChEMBL 973 16 8 14 1.0 CN1C(=O)[C@H](NC(=O)Nc2cccc(OCCNC(=O)COCC(=O)NNC(=O)COCC(=O)N[C@H]3CC[C@@]4(O)[C@H]5Cc6cc(O)cc7c6[C@@]4(CCN5C)[C@H]3O7)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm800174p
145991328 173686 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of non-sulfated CCK-8 from CCKB receptor (unknown origin) expressed in HEK cells after 4 hrs by RP-LC-ICPMS analysisDisplacement of non-sulfated CCK-8 from CCKB receptor (unknown origin) expressed in HEK cells after 4 hrs by RP-LC-ICPMS analysis
ChEMBL 1086 34 13 11 0.1 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCCNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC[Se]C)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01320
CHEMBL4286411 173686 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of non-sulfated CCK-8 from CCKB receptor (unknown origin) expressed in HEK cells after 4 hrs by RP-LC-ICPMS analysisDisplacement of non-sulfated CCK-8 from CCKB receptor (unknown origin) expressed in HEK cells after 4 hrs by RP-LC-ICPMS analysis
ChEMBL 1086 34 13 11 0.1 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCCNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC[Se]C)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01320
14802520 127138 1 None - 1 Mouse 8.4 pKi = 8.4 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 628 13 5 5 4.7 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CNC(=O)CCC(=O)O)Cc1ccccc1 10.1021/jm00087a011
CHEMBL353157 127138 1 None - 1 Mouse 8.4 pKi = 8.4 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 628 13 5 5 4.7 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CNC(=O)CCC(=O)O)Cc1ccccc1 10.1021/jm00087a011
44356448 175018 0 None 75 2 Mouse 8.4 pKi = 8.4 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 769 11 5 5 6.7 O=C(O)c1cc(NC(=O)[C@@H](Cc2cccc(F)c2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm00021a019
CHEMBL433656 175018 0 None 75 2 Mouse 8.4 pKi = 8.4 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 769 11 5 5 6.7 O=C(O)c1cc(NC(=O)[C@@H](Cc2cccc(F)c2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm00021a019
5311201 214174 35 None -26 6 Mouse 8.4 pKi = 8.4 Binding
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm000960w
CHEMBL9387 214174 35 None -26 6 Mouse 8.4 pKi = 8.4 Binding
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm000960w
118727699 124370 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of Eu-DTPA-PEGO-CCK4 from human cholecystokinin 2 receptor overexpressed in HEK-293 cells co-expressing human MC4R after 1 hr by time resolved fluorescence-based competition binding assayDisplacement of Eu-DTPA-PEGO-CCK4 from human cholecystokinin 2 receptor overexpressed in HEK-293 cells co-expressing human MC4R after 1 hr by time resolved fluorescence-based competition binding assay
ChEMBL 3179 132 21 45 9.8 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)COCCOCCOCCOCCOCCCCc1cn(CCCCCCOc2cc(OCCCCCCn3cc(CCCCOCCOCCOCCOCCOCC(=O)N[C@@H](Cc4c[nH]c5ccccc45)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc4ccccc4)C(N)=O)nn3)cc(OCCCCCCn3cc(CCCCOCCOCCOCCOCCOCC(=O)N[C@@H](Cc4c[nH]c5ccccc45)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc4ccccc4)C(N)=O)nn3)c2)nn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmc.2015.02.028
CHEMBL3400297 124370 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of Eu-DTPA-PEGO-CCK4 from human cholecystokinin 2 receptor overexpressed in HEK-293 cells co-expressing human MC4R after 1 hr by time resolved fluorescence-based competition binding assayDisplacement of Eu-DTPA-PEGO-CCK4 from human cholecystokinin 2 receptor overexpressed in HEK-293 cells co-expressing human MC4R after 1 hr by time resolved fluorescence-based competition binding assay
ChEMBL 3179 132 21 45 9.8 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)COCCOCCOCCOCCOCCCCc1cn(CCCCCCOc2cc(OCCCCCCn3cc(CCCCOCCOCCOCCOCCOCC(=O)N[C@@H](Cc4c[nH]c5ccccc45)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc4ccccc4)C(N)=O)nn3)cc(OCCCCCCn3cc(CCCCOCCOCCOCCOCCOCC(=O)N[C@@H](Cc4c[nH]c5ccccc45)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc4ccccc4)C(N)=O)nn3)c2)nn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmc.2015.02.028
44351445 123712 0 None 1 2 Human 7.5 pKi = 7.5 Binding
Binding affinity (affinity state 2) for Cholecystokinin type B receptor, was determined using CHO cellsBinding affinity (affinity state 2) for Cholecystokinin type B receptor, was determined using CHO cells
ChEMBL 654 8 3 6 5.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(Cl)cc2Cl)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL338525 123712 0 None 1 2 Human 7.5 pKi = 7.5 Binding
Binding affinity (affinity state 2) for Cholecystokinin type B receptor, was determined using CHO cellsBinding affinity (affinity state 2) for Cholecystokinin type B receptor, was determined using CHO cells
ChEMBL 654 8 3 6 5.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(Cl)cc2Cl)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL3351049 218312 0 None 2 2 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL None None None CN(C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1ccccc1)[C@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C 10.1021/jm00053a022
44271859 148303 0 None 4 2 Human 6.5 pKi = 6.5 Binding
Displacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranesDisplacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranes
ChEMBL 1292 39 14 16 2.0 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)CC[C@@H](NC(=O)OC(C)(C)C)C(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00126a007
CHEMBL384618 148303 0 None 4 2 Human 6.5 pKi = 6.5 Binding
Displacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranesDisplacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranes
ChEMBL 1292 39 14 16 2.0 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)CC[C@@H](NC(=O)OC(C)(C)C)C(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00126a007
44344616 120588 0 None - 1 Mouse 5.5 pKi = 5.5 Binding
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 583 6 1 5 3.9 O=C(O)CN1CC(=O)N2[C@@H](CC(=O)c3ccccc3N(Cc3ccccc3)C(=O)[C@H]2CC23CC4CC(CC(C4)C2)C3)C1=O 10.1021/jm000960w
CHEMBL332489 120588 0 None - 1 Mouse 5.5 pKi = 5.5 Binding
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 583 6 1 5 3.9 O=C(O)CN1CC(=O)N2[C@@H](CC(=O)c3ccccc3N(Cc3ccccc3)C(=O)[C@H]2CC23CC4CC(CC(C4)C2)C3)C1=O 10.1021/jm000960w
118719254 122252 0 None - 1 Mouse 6.5 pKi = 6.5 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 602 12 5 5 4.9 CC1(C)C2CCC1(C)[C@@H](OC(=O)N[C@H](Cc1c[nH]c3ccccc13)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1)C2 10.1021/jm00087a011
CHEMBL3351020 122252 0 None - 1 Mouse 6.5 pKi = 6.5 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 602 12 5 5 4.9 CC1(C)C2CCC1(C)[C@@H](OC(=O)N[C@H](Cc1c[nH]c3ccccc13)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1)C2 10.1021/jm00087a011
10413618 209570 0 None - 1 Mouse 6.5 pKi = 6.5 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 499 8 3 3 5.4 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 10.1021/jm00087a011
CHEMBL62205 209570 0 None - 1 Mouse 6.5 pKi = 6.5 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 499 8 3 3 5.4 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 10.1021/jm00087a011
11363465 88329 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 472 6 1 6 4.4 CN(Cc1ccccc1)C(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1021/jm060590x
CHEMBL216124 88329 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 472 6 1 6 4.4 CN(Cc1ccccc1)C(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1021/jm060590x
11259485 88366 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 450 4 1 6 4.2 CC1CCCCN1C(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1021/jm060590x
CHEMBL216320 88366 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 450 4 1 6 4.2 CC1CCCCN1C(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1021/jm060590x
11352971 88682 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 524 4 1 6 2.5 O=C(c1ccc(I)cc1NS(=O)(=O)c1cccc2nccnc12)N1CCOCC1 10.1021/jm060590x
CHEMBL216483 88682 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 524 4 1 6 2.5 O=C(c1ccc(I)cc1NS(=O)(=O)c1cccc2nccnc12)N1CCOCC1 10.1021/jm060590x
16090694 89129 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 530 4 1 7 2.6 O=C(c1ccc(I)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCOCC1 10.1021/jm060590x
CHEMBL217225 89129 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 530 4 1 7 2.6 O=C(c1ccc(I)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCOCC1 10.1021/jm060590x
11352971 88682 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]CCK8S from human CCK2RDisplacement of [125I]CCK8S from human CCK2R
ChEMBL 524 4 1 6 2.5 O=C(c1ccc(I)cc1NS(=O)(=O)c1cccc2nccnc12)N1CCOCC1 10.1016/j.bmc.2008.01.059
CHEMBL216483 88682 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]CCK8S from human CCK2RDisplacement of [125I]CCK8S from human CCK2R
ChEMBL 524 4 1 6 2.5 O=C(c1ccc(I)cc1NS(=O)(=O)c1cccc2nccnc12)N1CCOCC1 10.1016/j.bmc.2008.01.059
44404005 19057 0 None 100 2 Mouse 7.5 pKi = 7.5 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 623 11 5 5 5.0 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2ccccc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL1184845 19057 0 None 100 2 Mouse 7.5 pKi = 7.5 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 623 11 5 5 5.0 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2ccccc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL2067963 19057 0 None 100 2 Mouse 7.5 pKi = 7.5 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 623 11 5 5 5.0 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2ccccc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm049069y
57392083 75179 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of Eu-DTAP-CCK8-NH2 from CCK2 receptor expressed in human HEK293 cells after 1 hr by time resolved fluorescence methodDisplacement of Eu-DTAP-CCK8-NH2 from CCK2 receptor expressed in human HEK293 cells after 1 hr by time resolved fluorescence method
ChEMBL 735 23 7 8 2.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCCN=[N+]=[N-])C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmc.2011.08.053
CHEMBL1917058 75179 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of Eu-DTAP-CCK8-NH2 from CCK2 receptor expressed in human HEK293 cells after 1 hr by time resolved fluorescence methodDisplacement of Eu-DTAP-CCK8-NH2 from CCK2 receptor expressed in human HEK293 cells after 1 hr by time resolved fluorescence method
ChEMBL 735 23 7 8 2.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCCN=[N+]=[N-])C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmc.2011.08.053
CHEMBL440259 220641 0 None 4 2 Human 6.5 pKi = 6.5 Binding
Displacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranesDisplacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranes
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@@H](CCC(=O)O)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00126a007
11612498 140340 0 None -1 3 Mouse 6.5 pKi = 6.5 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 469 7 3 3 6.2 O=C(O)c1cccc(NC(=O)c2[nH]c(-c3ccccc3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
CHEMBL371068 140340 0 None -1 3 Mouse 6.5 pKi = 6.5 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 469 7 3 3 6.2 O=C(O)c1cccc(NC(=O)c2[nH]c(-c3ccccc3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
45486997 204562 0 None 12 2 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 486 7 1 6 4.5 CN(CCc1ccccc1)C(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.064
CHEMBL571832 204562 0 None 12 2 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 486 7 1 6 4.5 CN(CCc1ccccc1)C(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.064
16090688 87117 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 444 5 1 6 4.2 CC(C)c1ccc(C(=O)N2CCCCC2)c(NS(=O)(=O)c2cccc3nsnc23)c1 10.1021/jm060590x
CHEMBL214283 87117 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 444 5 1 6 4.2 CC(C)c1ccc(C(=O)N2CCCCC2)c(NS(=O)(=O)c2cccc3nsnc23)c1 10.1021/jm060590x
11305046 89168 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 432 4 1 6 2.6 O=C(c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nccnc12)N1CCOCC1 10.1021/jm060590x
CHEMBL217255 89168 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 432 4 1 6 2.6 O=C(c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nccnc12)N1CCOCC1 10.1021/jm060590x
11212985 89218 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 445 5 1 7 3.2 CN(C)c1ccc(C(=O)N2CCCCC2)c(NS(=O)(=O)c2cccc3nsnc23)c1 10.1021/jm060590x
CHEMBL217514 89218 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 445 5 1 7 3.2 CN(C)c1ccc(C(=O)N2CCCCC2)c(NS(=O)(=O)c2cccc3nsnc23)c1 10.1021/jm060590x
11154873 148763 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 438 4 1 7 2.6 O=C(c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCOCC1 10.1021/jm060590x
CHEMBL387413 148763 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 438 4 1 7 2.6 O=C(c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCOCC1 10.1021/jm060590x
25033306 101260 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 552 6 1 7 5.1 CSc1nccc(-c2ccc(S(=O)(=O)Nc3cc(Br)ccc3C(=O)N3CCCCC3)s2)n1 10.1016/j.bmcl.2007.09.087
CHEMBL251485 101260 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 552 6 1 7 5.1 CSc1nccc(-c2ccc(S(=O)(=O)Nc3cc(Br)ccc3C(=O)N3CCCCC3)s2)n1 10.1016/j.bmcl.2007.09.087
25033305 161515 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 478 4 1 4 5.1 O=C(c1ccc(Br)cc1NS(=O)(=O)c1csc2ccccc12)N1CCCCC1 10.1016/j.bmcl.2007.09.087
CHEMBL399919 161515 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 478 4 1 4 5.1 O=C(c1ccc(Br)cc1NS(=O)(=O)c1csc2ccccc12)N1CCCCC1 10.1016/j.bmcl.2007.09.087
25033149 165621 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [125I]CCK8S from human CCK2RDisplacement of [125I]CCK8S from human CCK2R
ChEMBL 479 4 1 5 4.5 O=C(c1ccc(Br)cc1NS(=O)(=O)c1ccc2ncsc2c1)N1CCCCC1 10.1016/j.bmc.2008.01.059
CHEMBL409479 165621 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [125I]CCK8S from human CCK2RDisplacement of [125I]CCK8S from human CCK2R
ChEMBL 479 4 1 5 4.5 O=C(c1ccc(Br)cc1NS(=O)(=O)c1ccc2ncsc2c1)N1CCCCC1 10.1016/j.bmc.2008.01.059
9844256 18569 0 None 3 2 Mouse 5.5 pKi = 5.5 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 406 7 3 2 4.6 O=C(O)CCNC(=O)c1cc(-c2ccccc2)[nH]c1CC12CC3CC(CC(C3)C1)C2 10.1021/jm049069y
CHEMBL1181869 18569 0 None 3 2 Mouse 5.5 pKi = 5.5 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 406 7 3 2 4.6 O=C(O)CCNC(=O)c1cc(-c2ccccc2)[nH]c1CC12CC3CC(CC(C3)C1)C2 10.1021/jm049069y
CHEMBL2067947 18569 0 None 3 2 Mouse 5.5 pKi = 5.5 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 406 7 3 2 4.6 O=C(O)CCNC(=O)c1cc(-c2ccccc2)[nH]c1CC12CC3CC(CC(C3)C1)C2 10.1021/jm049069y
10532660 120055 0 None - 1 Human 6.5 pKi = 6.5 Binding
Compound was tested for binding affinity against Cholecystokinin type B receptor on guinea pig cortex in experiment 2Compound was tested for binding affinity against Cholecystokinin type B receptor on guinea pig cortex in experiment 2
ChEMBL 690 19 7 7 1.0 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)/C=C\C(=O)O 10.1021/jm0000416
CHEMBL331495 120055 0 None - 1 Human 6.5 pKi = 6.5 Binding
Compound was tested for binding affinity against Cholecystokinin type B receptor on guinea pig cortex in experiment 2Compound was tested for binding affinity against Cholecystokinin type B receptor on guinea pig cortex in experiment 2
ChEMBL 690 19 7 7 1.0 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)/C=C\C(=O)O 10.1021/jm0000416
44351524 26109 0 None - 1 Human 7.5 pKi = 7.5 Binding
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 604 7 3 5 5.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](c2ccc(Cl)cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL129070 26109 0 None - 1 Human 7.5 pKi = 7.5 Binding
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 604 7 3 5 5.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](c2ccc(Cl)cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
10651635 172051 0 None - 1 Rat 7.5 pKi = 7.5 Binding
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 630 9 3 7 5.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1C[C@H](Oc2ccc([N+](=O)[O-])cc2)C[C@@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
CHEMBL423119 172051 0 None - 1 Rat 7.5 pKi = 7.5 Binding
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 630 9 3 7 5.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1C[C@H](Oc2ccc([N+](=O)[O-])cc2)C[C@@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
44351446 162920 0 None -3 2 Rat 7.5 pKi = 7.5 Binding
Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.
ChEMBL 631 9 3 8 4.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc([N+](=O)[O-])cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL406359 162920 0 None -3 2 Rat 7.5 pKi = 7.5 Binding
Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.
ChEMBL 631 9 3 8 4.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc([N+](=O)[O-])cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
10004216 11515 0 None 11 2 Human 6.5 pKi = 6.5 Binding
Binding affinity was measured by its ability to displace [3H]CCK-8S from CCK-B receptor in guinea pig brainBinding affinity was measured by its ability to displace [3H]CCK-8S from CCK-B receptor in guinea pig brain
ChEMBL 456 6 2 3 4.9 CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21 10.1016/0960-894X(95)00528-2
CHEMBL103750 11515 0 None 11 2 Human 6.5 pKi = 6.5 Binding
Binding affinity was measured by its ability to displace [3H]CCK-8S from CCK-B receptor in guinea pig brainBinding affinity was measured by its ability to displace [3H]CCK-8S from CCK-B receptor in guinea pig brain
ChEMBL 456 6 2 3 4.9 CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21 10.1016/0960-894X(95)00528-2
11505870 79282 0 None 2 3 Mouse 6.5 pKi = 6.5 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 526 8 3 4 6.6 Cc1ccccc1-c1nc(CCC23CC4CC(CC(C4)C2)C3)c(C(=O)Nc2ccc(N(C)C)c(C(=O)O)c2)[nH]1 10.1021/jm0490686
CHEMBL199032 79282 0 None 2 3 Mouse 6.5 pKi = 6.5 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 526 8 3 4 6.6 Cc1ccccc1-c1nc(CCC23CC4CC(CC(C4)C2)C3)c(C(=O)Nc2ccc(N(C)C)c(C(=O)O)c2)[nH]1 10.1021/jm0490686
44351444 123664 0 None -1 2 Human 6.5 pKi = 6.5 Binding
Binding affinity (affinity state 2) for Cholecystokinin type B receptor, was determined using CHO cellsBinding affinity (affinity state 2) for Cholecystokinin type B receptor, was determined using CHO cells
ChEMBL 622 8 3 6 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(F)cc2F)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL338300 123664 0 None -1 2 Human 6.5 pKi = 6.5 Binding
Binding affinity (affinity state 2) for Cholecystokinin type B receptor, was determined using CHO cellsBinding affinity (affinity state 2) for Cholecystokinin type B receptor, was determined using CHO cells
ChEMBL 622 8 3 6 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(F)cc2F)C[C@@H]1C(=O)O 10.1021/jm970439a
44580899 195854 0 None -4 2 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]CCK-26-33 from CCK2R-MOPR coexpressed in CHO cellsDisplacement of [125I]CCK-26-33 from CCK2R-MOPR coexpressed in CHO cells
ChEMBL 1001 19 8 14 1.1 CN1C(=O)[C@H](NC(=O)Nc2cccc(OCCNC(=O)COCC(=O)NCCNC(=O)COCC(=O)N[C@H]3CC[C@@]4(O)[C@H]5Cc6cc(O)cc7c6[C@@]4(CCN5C)[C@H]3O7)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm800174p
CHEMBL509792 195854 0 None -4 2 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]CCK-26-33 from CCK2R-MOPR coexpressed in CHO cellsDisplacement of [125I]CCK-26-33 from CCK2R-MOPR coexpressed in CHO cells
ChEMBL 1001 19 8 14 1.1 CN1C(=O)[C@H](NC(=O)Nc2cccc(OCCNC(=O)COCC(=O)NCCNC(=O)COCC(=O)N[C@H]3CC[C@@]4(O)[C@H]5Cc6cc(O)cc7c6[C@@]4(CCN5C)[C@H]3O7)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm800174p
44331467 114230 0 None 41 2 Human 7.5 pKi = 7.5 Binding
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 529 7 1 4 5.8 CC(C)CCN1C(=O)C(NC(=O)Oc2ccccc2)C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc21 10.1016/S0960-894X(96)00544-6
CHEMBL318291 114230 0 None 41 2 Human 7.5 pKi = 7.5 Binding
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 529 7 1 4 5.8 CC(C)CCN1C(=O)C(NC(=O)Oc2ccccc2)C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc21 10.1016/S0960-894X(96)00544-6
10506830 120744 0 None 6 2 Human 7.5 pKi = 7.5 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 548 6 2 3 6.5 O=C(Nc1ccccc1)NC1C(=O)N(CCC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
CHEMBL332601 120744 0 None 6 2 Human 7.5 pKi = 7.5 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 548 6 2 3 6.5 O=C(Nc1ccccc1)NC1C(=O)N(CCC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
11801462 124244 0 None - 1 Human 6.5 pKi = 6.5 Binding
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 585 8 3 5 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@@H](Oc2ccccc2)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL339907 124244 0 None - 1 Human 6.5 pKi = 6.5 Binding
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 585 8 3 5 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@@H](Oc2ccccc2)C[C@@H]1C(=O)O 10.1021/jm970439a
16732598 92215 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 476 7 2 5 4.1 CC(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL226571 92215 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 476 7 2 5 4.1 CC(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
15513861 19249 0 None - 1 Mouse 6.5 pKi = 6.5 Binding
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 588 7 1 5 5.2 CC(=O)N1[C@H](C(=O)CC(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2F)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
CHEMBL118630 19249 0 None - 1 Mouse 6.5 pKi = 6.5 Binding
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 588 7 1 5 5.2 CC(=O)N1[C@H](C(=O)CC(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2F)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
CHEMBL386304 219159 0 None 6 2 Human 6.5 pKi = 6.5 Binding
Displacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranesDisplacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranes
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CCC(=O)O)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00126a007
11802782 21332 0 None - 1 Human 5.5 pKi = 5.5 Binding
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 692 19 7 7 1.1 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)C(=O)O 10.1021/jm0000416
CHEMBL120401 21332 0 None - 1 Human 5.5 pKi = 5.5 Binding
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 692 19 7 7 1.1 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)C(=O)O 10.1021/jm0000416
11798204 201372 0 None 10 2 Mouse 6.5 pKi = 6.5 Binding
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 460 5 2 3 4.5 O=C(NCC12CC3CC(CC(C3)C1)C2)c1cc2ccccc2cc1C(=O)N1CCC[C@@H]1C(=O)O 10.1021/jm9508907
CHEMBL53129 201372 0 None 10 2 Mouse 6.5 pKi = 6.5 Binding
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 460 5 2 3 4.5 O=C(NCC12CC3CC(CC(C3)C1)C2)c1cc2ccccc2cc1C(=O)N1CCC[C@@H]1C(=O)O 10.1021/jm9508907
44331343 11183 0 None 57 2 Human 7.5 pKi = 7.5 Binding
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 606 6 2 3 7.0 O=C(Nc1ccccc1)NC1C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc2N(CC23CC4CC(CC(C4)C2)C3)C1=O 10.1016/S0960-894X(96)00544-6
CHEMBL101456 11183 0 None 57 2 Human 7.5 pKi = 7.5 Binding
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 606 6 2 3 7.0 O=C(Nc1ccccc1)NC1C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc2N(CC23CC4CC(CC(C4)C2)C3)C1=O 10.1016/S0960-894X(96)00544-6
44280114 11882 0 None -1 2 Rat 5.5 pKi = 5.5 Binding
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 567 7 2 4 6.1 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1CCC(C(=O)c2ccccc2)CC1 10.1016/s0960-894x(98)00231-5
CHEMBL105618 11882 0 None -1 2 Rat 5.5 pKi = 5.5 Binding
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 567 7 2 4 6.1 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1CCC(C(=O)c2ccccc2)CC1 10.1016/s0960-894x(98)00231-5
14208194 170215 2 None -1122 2 Rat 6.5 pKi = 6.5 Binding
Inhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranesInhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranes
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm9703247
CHEMBL419764 170215 2 None -1122 2 Rat 6.5 pKi = 6.5 Binding
Inhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranesInhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranes
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm9703247
10255015 215082 0 None -4 2 Human 5.5 pKi = 5.5 Binding
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 490 8 4 2 5.8 CC(Cc1c[nH]c2ccccc12)(NC(=O)Nc1ccc2ccccc2c1)C(=O)NCCc1ccccc1 10.1021/jm00072a005
CHEMBL99065 215082 0 None -4 2 Human 5.5 pKi = 5.5 Binding
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 490 8 4 2 5.8 CC(Cc1c[nH]c2ccccc12)(NC(=O)Nc1ccc2ccccc2c1)C(=O)NCCc1ccccc1 10.1021/jm00072a005
70693901 80734 0 None - 1 Mouse 6.5 pKi = 6.5 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 600 12 5 5 4.5 O=C(O)CCC(=O)NC(CNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3)c1ccccc1 10.1021/jm00087a011
CHEMBL2021373 80734 0 None - 1 Mouse 6.5 pKi = 6.5 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 600 12 5 5 4.5 O=C(O)CCC(=O)NC(CNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3)c1ccccc1 10.1021/jm00087a011
44580898 195141 0 None -5 2 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]CCK-26-33 from CCK2 receptor expressed in CHO cellsDisplacement of [125I]CCK-26-33 from CCK2 receptor expressed in CHO cells
ChEMBL 973 16 8 14 1.0 CN1C(=O)[C@H](NC(=O)Nc2cccc(OCCNC(=O)COCC(=O)NNC(=O)COCC(=O)N[C@H]3CC[C@@]4(O)[C@H]5Cc6cc(O)cc7c6[C@@]4(CCN5C)[C@H]3O7)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm800174p
CHEMBL501238 195141 0 None -5 2 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]CCK-26-33 from CCK2 receptor expressed in CHO cellsDisplacement of [125I]CCK-26-33 from CCK2 receptor expressed in CHO cells
ChEMBL 973 16 8 14 1.0 CN1C(=O)[C@H](NC(=O)Nc2cccc(OCCNC(=O)COCC(=O)NNC(=O)COCC(=O)N[C@H]3CC[C@@]4(O)[C@H]5Cc6cc(O)cc7c6[C@@]4(CCN5C)[C@H]3O7)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm800174p
90662935 113352 0 None -10 2 Rat 7.4 pKi = 7.4 Binding
Binding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligand
ChEMBL 1057 30 11 11 2.6 CCCC[C@H](NC(=O)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C/c1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm990252e
CHEMBL3142373 113352 0 None -10 2 Rat 7.4 pKi = 7.4 Binding
Binding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligand
ChEMBL 1057 30 11 11 2.6 CCCC[C@H](NC(=O)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C/c1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm990252e
CHEMBL3351062 218322 0 None 173 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1cccc2ccccc12)C(=O)N(C)[C@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C 10.1021/jm00053a022
9808153 119451 0 None 36 2 Human 7.4 pKi = 7.4 Binding
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 571 11 3 4 5.6 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCC(=O)O)CCc1ccccc1 10.1021/jm00072a005
CHEMBL330390 119451 0 None 36 2 Human 7.4 pKi = 7.4 Binding
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 571 11 3 4 5.6 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCC(=O)O)CCc1ccccc1 10.1021/jm00072a005
10054705 115204 0 None 28 2 Human 7.4 pKi = 7.4 Binding
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 625 10 3 4 6.5 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccc(Cl)cc1Cl)CC(=O)O 10.1021/jm00072a005
CHEMBL319880 115204 0 None 28 2 Human 7.4 pKi = 7.4 Binding
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 625 10 3 4 6.5 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccc(Cl)cc1Cl)CC(=O)O 10.1021/jm00072a005
11216391 170272 0 None -1348 2 Rat 5.4 pKi = 5.4 Binding
Ability to displace 1 nM [3H]pCCK-8 from rat Cholecystokinin type B receptor stably expressing in CHO cellsAbility to displace 1 nM [3H]pCCK-8 from rat Cholecystokinin type B receptor stably expressing in CHO cells
ChEMBL 747 23 7 7 2.1 CCCCCNC(=O)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2003.11.001
CHEMBL420161 170272 0 None -1348 2 Rat 5.4 pKi = 5.4 Binding
Ability to displace 1 nM [3H]pCCK-8 from rat Cholecystokinin type B receptor stably expressing in CHO cellsAbility to displace 1 nM [3H]pCCK-8 from rat Cholecystokinin type B receptor stably expressing in CHO cells
ChEMBL 747 23 7 7 2.1 CCCCCNC(=O)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2003.11.001
15513859 120587 0 None - 1 Mouse 6.4 pKi = 6.4 Binding
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 680 8 2 7 3.3 CC(=O)N1[C@H](C(=O)NCC(=O)NS(C)(=O)=O)CC(=O)c2ccccc2N(Cc2ccccc2F)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
CHEMBL332488 120587 0 None - 1 Mouse 6.4 pKi = 6.4 Binding
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 680 8 2 7 3.3 CC(=O)N1[C@H](C(=O)NCC(=O)NS(C)(=O)=O)CC(=O)c2ccccc2N(Cc2ccccc2F)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
44451523 102718 0 None 1 2 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 541 7 2 5 4.1 O=C(CN1C(=O)N(CC(=O)N2CCCC2)c2ccccc2N(c2ccccc2)C1=O)Nc1cccc(C(=O)O)c1 10.1016/j.bmc.2007.12.047
CHEMBL259390 102718 0 None 1 2 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 541 7 2 5 4.1 O=C(CN1C(=O)N(CC(=O)N2CCCC2)c2ccccc2N(c2ccccc2)C1=O)Nc1cccc(C(=O)O)c1 10.1016/j.bmc.2007.12.047
44408524 162484 0 None -158 4 Human 5.4 pKi = 5.4 Binding
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1134 30 12 15 2.6 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)C(=O)O 10.1021/jm050851n
CHEMBL405192 162484 0 None -158 4 Human 5.4 pKi = 5.4 Binding
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1134 30 12 15 2.6 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)C(=O)O 10.1021/jm050851n
11512746 77385 0 None - 1 Mouse 5.4 pKi = 5.4 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 405 6 3 3 5.3 Cc1ccccc1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC(C)(C)C)[nH]1 10.1021/jm0490686
CHEMBL194974 77385 0 None - 1 Mouse 5.4 pKi = 5.4 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 405 6 3 3 5.3 Cc1ccccc1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC(C)(C)C)[nH]1 10.1021/jm0490686
118719285 122261 0 None 1 3 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL 733 15 5 7 4.7 CN(C)[C@@H](Cc1cccc2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C)c1ccccc1 10.1021/jm00053a022
CHEMBL3351057 122261 0 None 1 3 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL 733 15 5 7 4.7 CN(C)[C@@H](Cc1cccc2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C)c1ccccc1 10.1021/jm00053a022
10482233 174981 0 None 41 2 Human 7.4 pKi = 7.4 Binding
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 533 8 3 3 6.0 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccc(Cl)cc1 10.1021/jm00072a005
CHEMBL433407 174981 0 None 41 2 Human 7.4 pKi = 7.4 Binding
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 533 8 3 3 6.0 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccc(Cl)cc1 10.1021/jm00072a005
10440219 175477 0 None 25 2 Human 7.4 pKi = 7.4 Binding
Tested for the inhibition of [3H]pCCK-8 to Cholecystokinin type B receptor in guinea pig brainTested for the inhibition of [3H]pCCK-8 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL 776 15 6 7 4.4 CN(C)C(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)c1ccccc1 10.1016/S0960-894X(00)80678-2
CHEMBL436722 175477 0 None 25 2 Human 7.4 pKi = 7.4 Binding
Tested for the inhibition of [3H]pCCK-8 to Cholecystokinin type B receptor in guinea pig brainTested for the inhibition of [3H]pCCK-8 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL 776 15 6 7 4.4 CN(C)C(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)c1ccccc1 10.1016/S0960-894X(00)80678-2
11518283 172939 0 None -5 3 Mouse 7.4 pKi = 7.4 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 461 7 3 3 6.2 O=C(O)c1cccc(NC(=O)c2[nH]c(C3CCCC3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
CHEMBL426290 172939 0 None -5 3 Mouse 7.4 pKi = 7.4 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 461 7 3 3 6.2 O=C(O)c1cccc(NC(=O)c2[nH]c(C3CCCC3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
45486955 204177 0 None 5 2 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 628 8 3 7 5.0 O=C(N[C@@H](Cc1ccc(Cl)c(Br)c1)C(=O)O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.064
CHEMBL569470 204177 0 None 5 2 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 628 8 3 7 5.0 O=C(N[C@@H](Cc1ccc(Cl)c(Br)c1)C(=O)O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.064
16090781 148742 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 498 4 1 6 4.0 O=C(c1ccc(Br)cc1NS(=O)(=O)c1c(F)ccc2nsnc12)N1CCCCC1 10.1021/jm060590x
CHEMBL387287 148742 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 498 4 1 6 4.0 O=C(c1ccc(Br)cc1NS(=O)(=O)c1c(F)ccc2nsnc12)N1CCCCC1 10.1021/jm060590x
11453391 175619 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 436 4 1 6 3.8 O=C(c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
CHEMBL437908 175619 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 436 4 1 6 3.8 O=C(c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
11453391 175619 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]CCK8S from human CCK2RDisplacement of [125I]CCK8S from human CCK2R
ChEMBL 436 4 1 6 3.8 O=C(c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1016/j.bmc.2008.01.059
CHEMBL437908 175619 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]CCK8S from human CCK2RDisplacement of [125I]CCK8S from human CCK2R
ChEMBL 436 4 1 6 3.8 O=C(c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1016/j.bmc.2008.01.059
118719084 127381 0 None - 1 Mouse 6.4 pKi = 6.4 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 602 12 5 5 4.9 CC1(C)C2CCC1(C)[C@@H](OC(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1)C2 10.1021/jm00087a011
CHEMBL3350691 127381 0 None - 1 Mouse 6.4 pKi = 6.4 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 602 12 5 5 4.9 CC1(C)C2CCC1(C)[C@@H](OC(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1)C2 10.1021/jm00087a011
CHEMBL3545975 127381 0 None - 1 Mouse 6.4 pKi = 6.4 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 602 12 5 5 4.9 CC1(C)C2CCC1(C)[C@@H](OC(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1)C2 10.1021/jm00087a011
45486933 203715 1 None -3 2 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 520 7 2 6 5.3 CC(CNC(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.09.064
CHEMBL566360 203715 1 None -3 2 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 520 7 2 6 5.3 CC(CNC(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.09.064
1098327 148741 5 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 436 4 1 6 3.8 O=C(c1cc(Cl)ccc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1016/j.bmcl.2007.09.087
CHEMBL387285 148741 5 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 436 4 1 6 3.8 O=C(c1cc(Cl)ccc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1016/j.bmcl.2007.09.087
1098327 148741 5 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 436 4 1 6 3.8 O=C(c1cc(Cl)ccc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
CHEMBL387285 148741 5 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 436 4 1 6 3.8 O=C(c1cc(Cl)ccc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
44403999 19056 0 None 12 2 Mouse 6.4 pKi = 6.4 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 619 10 5 5 5.2 O=C(O)c1cccc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm049069y
CHEMBL1184841 19056 0 None 12 2 Mouse 6.4 pKi = 6.4 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 619 10 5 5 5.2 O=C(O)c1cccc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm049069y
CHEMBL2067962 19056 0 None 12 2 Mouse 6.4 pKi = 6.4 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 619 10 5 5 5.2 O=C(O)c1cccc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm049069y
25033307 101295 0 None - 1 Human 5.4 pKi = 5.4 Binding
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 525 5 1 6 5.4 Cc1nc(-c2ccc(S(=O)(=O)Nc3cc(Br)ccc3C(=O)N3CCCCC3)s2)cs1 10.1016/j.bmcl.2007.09.087
CHEMBL251655 101295 0 None - 1 Human 5.4 pKi = 5.4 Binding
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 525 5 1 6 5.4 Cc1nc(-c2ccc(S(=O)(=O)Nc3cc(Br)ccc3C(=O)N3CCCCC3)s2)cs1 10.1016/j.bmcl.2007.09.087
16090652 148340 0 None - 1 Human 5.4 pKi = 5.4 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 416 4 1 6 2.0 O=C(c1ccc(F)cc1NS(=O)(=O)c1cccc2nccnc12)N1CCOCC1 10.1021/jm060590x
CHEMBL384854 148340 0 None - 1 Human 5.4 pKi = 5.4 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 416 4 1 6 2.0 O=C(c1ccc(F)cc1NS(=O)(=O)c1cccc2nccnc12)N1CCOCC1 10.1021/jm060590x
16090693 148463 0 None - 1 Human 5.4 pKi = 5.4 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 422 4 1 7 2.1 O=C(c1ccc(F)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCOCC1 10.1021/jm060590x
CHEMBL385552 148463 0 None - 1 Human 5.4 pKi = 5.4 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 422 4 1 7 2.1 O=C(c1ccc(F)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCOCC1 10.1021/jm060590x
9956948 18700 0 None -1 2 Mouse 5.4 pKi = 5.4 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 483 7 4 4 6.0 O=C(Nc1cc(CO)cc(CO)c1)c1[nH]c(-c2ccc3ccccc3c2)nc1CC1CCCCCC1 10.1021/jm049069y
CHEMBL1182723 18700 0 None -1 2 Mouse 5.4 pKi = 5.4 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 483 7 4 4 6.0 O=C(Nc1cc(CO)cc(CO)c1)c1[nH]c(-c2ccc3ccccc3c2)nc1CC1CCCCCC1 10.1021/jm049069y
CHEMBL2067953 18700 0 None -1 2 Mouse 5.4 pKi = 5.4 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 483 7 4 4 6.0 O=C(Nc1cc(CO)cc(CO)c1)c1[nH]c(-c2ccc3ccccc3c2)nc1CC1CCCCCC1 10.1021/jm049069y
10605398 121274 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 807 21 8 9 1.8 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H](NC(=O)OC(C)(C)C)C(=O)O 10.1021/jm0000416
CHEMBL333516 121274 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 807 21 8 9 1.8 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H](NC(=O)OC(C)(C)C)C(=O)O 10.1021/jm0000416
16733645 19953 0 None 416 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 598 9 2 7 5.4 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3cn(CC(=O)O)cn3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL1190962 19953 0 None 416 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 598 9 2 7 5.4 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3cn(CC(=O)O)cn3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL541903 19953 0 None 416 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 598 9 2 7 5.4 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3cn(CC(=O)O)cn3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
10604847 201456 0 None 218 2 Mouse 8.4 pKi = 8.4 Binding
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 711 11 6 10 3.8 O=C(NCC12CC3CC(CC(C3)C1)C2)c1cc2nc[nH]c2cc1C(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1cc(-c2nn[nH]n2)cc(-c2nn[nH]n2)c1 10.1021/jm9508907
CHEMBL53237 201456 0 None 218 2 Mouse 8.4 pKi = 8.4 Binding
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 711 11 6 10 3.8 O=C(NCC12CC3CC(CC(C3)C1)C2)c1cc2nc[nH]c2cc1C(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1cc(-c2nn[nH]n2)cc(-c2nn[nH]n2)c1 10.1021/jm9508907
10004216 11515 0 None 11 2 Human 8.4 pKi = 8.4 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 456 6 2 3 4.9 CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21 10.1021/jm990967h
CHEMBL103750 11515 0 None 11 2 Human 8.4 pKi = 8.4 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 456 6 2 3 4.9 CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21 10.1021/jm990967h
44451547 103487 0 None 2 3 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 587 8 2 8 4.7 CN(c1cccc(NC(=O)CN2C(=O)N(CC(=O)C(C)(C)C)c3ccccc3N(C3CCCCC3)C2=O)c1)c1nn[nH]n1 10.1016/j.bmc.2007.12.047
CHEMBL264150 103487 0 None 2 3 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 587 8 2 8 4.7 CN(c1cccc(NC(=O)CN2C(=O)N(CC(=O)C(C)(C)C)c3ccccc3N(C3CCCCC3)C2=O)c1)c1nn[nH]n1 10.1016/j.bmc.2007.12.047
16733057 143732 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 596 9 2 7 4.3 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(S(=O)(=O)CC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL374389 143732 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 596 9 2 7 4.3 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(S(=O)(=O)CC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
10628607 123552 0 None 467 2 Mouse 8.4 pKi = 8.4 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 713 11 5 5 6.4 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC2CCCCCC2)cc(C(=O)O)c1 10.1021/jm00021a019
CHEMBL337673 123552 0 None 467 2 Mouse 8.4 pKi = 8.4 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 713 11 5 5 6.4 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC2CCCCCC2)cc(C(=O)O)c1 10.1021/jm00021a019
10842269 108351 0 None 575 2 Mouse 8.4 pKi = 8.4 Binding
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 681 11 6 6 5.0 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2F)NC(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm9508907
CHEMBL298551 108351 0 None 575 2 Mouse 8.4 pKi = 8.4 Binding
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 681 11 6 6 5.0 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2F)NC(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm9508907
16733182 105343 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 556 8 2 7 4.6 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(Cc3nnn[nH]3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL276645 105343 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 556 8 2 7 4.6 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(Cc3nnn[nH]3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
10697783 124411 0 None 141 2 Human 8.3 pKi = 8.3 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 543 7 2 4 5.7 CN(C)c1ccc(NC(=O)NC2C(=O)N(CCC3CCCC3)c3ccccc3N(c3ccccc3F)C2=O)cc1 10.1021/jm990967h
CHEMBL340107 124411 0 None 141 2 Human 8.3 pKi = 8.3 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 543 7 2 4 5.7 CN(C)c1ccc(NC(=O)NC2C(=O)N(CCC3CCCC3)c3ccccc3N(c3ccccc3F)C2=O)cc1 10.1021/jm990967h
44272076 175588 0 None 407 2 Human 8.3 pKi = 8.3 Binding
Displacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranesDisplacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranes
ChEMBL 1194 24 13 13 2.6 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCCNC(=O)[C@H](NC(=O)OC(C)(C)C)CCC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccccc1)C(N)=O 10.1021/jm00126a007
CHEMBL437661 175588 0 None 407 2 Human 8.3 pKi = 8.3 Binding
Displacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranesDisplacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranes
ChEMBL 1194 24 13 13 2.6 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCCNC(=O)[C@H](NC(=O)OC(C)(C)C)CCC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccccc1)C(N)=O 10.1021/jm00126a007
16732443 92272 0 None 1202 2 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 532 7 2 5 5.6 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL227147 92272 0 None 1202 2 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 532 7 2 5 5.6 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL331517 218157 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](N)CC(=O)O 10.1021/jm0000416
CHEMBL336381 218362 0 None 97 5 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
10101023 96232 0 None 57 2 Human 7.4 pKi = 7.4 Binding
Inhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptorInhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptor
ChEMBL 675 11 8 7 -0.1 C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CC(=O)NCCCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm9603072
CHEMBL2371224 96232 0 None 57 2 Human 7.4 pKi = 7.4 Binding
Inhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptorInhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptor
ChEMBL 675 11 8 7 -0.1 C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CC(=O)NCCCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm9603072
10482868 114181 0 None -2 5 Rat 7.4 pKi = 7.4 Binding
Tested for binding affinity towards cholecystokinin type B receptor in rat cortex by displacement of [3H]pBC264 radioligandTested for binding affinity towards cholecystokinin type B receptor in rat cortex by displacement of [3H]pBC264 radioligand
ChEMBL 557 10 3 4 5.2 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccc1)CC(=O)O 10.1021/jm00072a005
CHEMBL317999 114181 0 None -2 5 Rat 7.4 pKi = 7.4 Binding
Tested for binding affinity towards cholecystokinin type B receptor in rat cortex by displacement of [3H]pBC264 radioligandTested for binding affinity towards cholecystokinin type B receptor in rat cortex by displacement of [3H]pBC264 radioligand
ChEMBL 557 10 3 4 5.2 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccc1)CC(=O)O 10.1021/jm00072a005
44346825 121551 0 None 77 2 Mouse 7.4 pKi = 7.4 Binding
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 623 8 3 4 4.7 C[C@@H](NC(=O)C[C@@H]1CCCN1C(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC1C2CC3CC(C2)CC1C3)C(=O)O 10.1021/jm00048a001
CHEMBL333920 121551 0 None 77 2 Mouse 7.4 pKi = 7.4 Binding
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 623 8 3 4 4.7 C[C@@H](NC(=O)C[C@@H]1CCCN1C(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC1C2CC3CC(C2)CC1C3)C(=O)O 10.1021/jm00048a001
10006936 214504 0 None 5 2 Human 6.4 pKi = 6.4 Binding
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 521 6 3 3 6.8 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)Nc1ccc2ccccc2c1 10.1021/jm00072a005
CHEMBL95689 214504 0 None 5 2 Human 6.4 pKi = 6.4 Binding
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 521 6 3 3 6.8 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)Nc1ccc2ccccc2c1 10.1021/jm00072a005
10367509 114219 0 None 14 2 Human 6.4 pKi = 6.4 Binding
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 471 6 3 3 5.7 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)Nc1ccccc1 10.1021/jm00072a005
CHEMBL318238 114219 0 None 14 2 Human 6.4 pKi = 6.4 Binding
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 471 6 3 3 5.7 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)Nc1ccccc1 10.1021/jm00072a005
44344932 19190 0 None - 1 Mouse 6.4 pKi = 6.4 Binding
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 603 7 2 5 4.3 CC(=O)N1C(C(=O)NCC(=O)O)CC(=O)c2cc(F)ccc2N(Cc2ccccc2)C(=O)C1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
CHEMBL118584 19190 0 None - 1 Mouse 6.4 pKi = 6.4 Binding
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 603 7 2 5 4.3 CC(=O)N1C(C(=O)NCC(=O)O)CC(=O)c2cc(F)ccc2N(Cc2ccccc2)C(=O)C1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
CHEMBL64605 222635 7 None -4 3 Human 7.4 pKi = 7.4 Binding
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm0000416
44331483 114275 0 None 25 2 Human 7.4 pKi = 7.4 Binding
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 541 5 1 4 6.1 O=C(NC1C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc2N(C2CCCCC2)C1=O)Oc1ccccc1 10.1016/S0960-894X(96)00544-6
CHEMBL318569 114275 0 None 25 2 Human 7.4 pKi = 7.4 Binding
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 541 5 1 4 6.1 O=C(NC1C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc2N(C2CCCCC2)C1=O)Oc1ccccc1 10.1016/S0960-894X(96)00544-6
CHEMBL3350278 218245 0 None -20 2 Human 5.4 pKi = 5.4 Binding
Apparent affinity to inhibit binding of [3H]pCCK-8 to Cholecystokinin type B receptor of guinea pig brain membranesApparent affinity to inhibit binding of [3H]pCCK-8 to Cholecystokinin type B receptor of guinea pig brain membranes
ChEMBL None None None CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(N)=O 10.1021/jm00174a016
11800431 17796 0 None - 1 Mouse 5.4 pKi = 5.4 Binding
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 533 7 2 5 3.6 CC(=O)N1[C@H](C(=O)NCC(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2)C(=O)[C@H]1CC1CCCCC1 10.1021/jm000960w
CHEMBL117510 17796 0 None - 1 Mouse 5.4 pKi = 5.4 Binding
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 533 7 2 5 3.6 CC(=O)N1[C@H](C(=O)NCC(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2)C(=O)[C@H]1CC1CCCCC1 10.1021/jm000960w
11804040 126226 0 None -2137 2 Rat 6.4 pKi = 6.4 Binding
Binding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomesBinding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomes
ChEMBL 976 28 9 11 1.6 CCCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm970477u
CHEMBL345049 126226 0 None -2137 2 Rat 6.4 pKi = 6.4 Binding
Binding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomesBinding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomes
ChEMBL 976 28 9 11 1.6 CCCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm970477u
CHEMBL3142843 217915 0 None 6 2 Human 5.4 pKi = 5.4 Binding
Apparent affinity to inhibit binding of [3H]pCCK-8 to Cholecystokinin type B receptor of guinea pig brain membranesApparent affinity to inhibit binding of [3H]pCCK-8 to Cholecystokinin type B receptor of guinea pig brain membranes
ChEMBL None None None CC(C)(C)OC(=O)NCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(N)=O 10.1021/jm00174a016
10508568 96231 0 None - 1 Human 5.4 pKi = 5.4 Binding
Inhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptorInhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptor
ChEMBL 660 11 7 6 2.0 C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm9603072
CHEMBL2371223 96231 0 None - 1 Human 5.4 pKi = 5.4 Binding
Inhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptorInhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptor
ChEMBL 660 11 7 6 2.0 C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm9603072
11592162 83304 0 None 2 2 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 561 11 2 6 5.9 CCOCCNc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
CHEMBL206079 83304 0 None 2 2 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 561 11 2 6 5.9 CCOCCNc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
44351454 123596 0 None 1 2 Human 7.4 pKi = 7.4 Binding
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 712 8 3 6 5.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(I)cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL337933 123596 0 None 1 2 Human 7.4 pKi = 7.4 Binding
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 712 8 3 6 5.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(I)cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
11561828 147405 0 None 4 2 Mouse 6.4 pKi = 6.4 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 468 7 3 2 6.8 O=C(O)c1cccc(NC(=O)c2cc(-c3ccccc3)[nH]c2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
CHEMBL381426 147405 0 None 4 2 Mouse 6.4 pKi = 6.4 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 468 7 3 2 6.8 O=C(O)c1cccc(NC(=O)c2cc(-c3ccccc3)[nH]c2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
44351445 123712 0 None 1 2 Human 7.3 pKi = 7.3 Binding
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 654 8 3 6 5.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(Cl)cc2Cl)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL338525 123712 0 None 1 2 Human 7.3 pKi = 7.3 Binding
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 654 8 3 6 5.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(Cl)cc2Cl)C[C@@H]1C(=O)O 10.1021/jm970439a
10323690 106079 0 None - 1 Mouse 7.3 pKi = 7.3 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 499 8 3 3 5.4 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 10.1021/jm00087a011
CHEMBL282056 106079 0 None - 1 Mouse 7.3 pKi = 7.3 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 499 8 3 3 5.4 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 10.1021/jm00087a011
11511706 79036 0 None 1 3 Mouse 7.3 pKi = 7.3 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 501 7 3 3 6.6 Cc1ccccc1-c1nc(C(=O)Nc2ccc(F)c(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
CHEMBL198225 79036 0 None 1 3 Mouse 7.3 pKi = 7.3 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 501 7 3 3 6.6 Cc1ccccc1-c1nc(C(=O)Nc2ccc(F)c(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
44344987 120585 0 None - 1 Mouse 7.3 pKi = 7.3 Binding
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 633 7 2 5 5.2 CC(=O)N1[C@H](C(=O)N[C@H](C)C(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2Cl)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
CHEMBL332482 120585 0 None - 1 Mouse 7.3 pKi = 7.3 Binding
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 633 7 2 5 5.2 CC(=O)N1[C@H](C(=O)N[C@H](C)C(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2Cl)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
10557073 23144 0 None -3467 2 Human 5.3 pKi = 5.3 Binding
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 763 20 7 8 2.3 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C 10.1021/jm0000416
CHEMBL122934 23144 0 None -3467 2 Human 5.3 pKi = 5.3 Binding
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 763 20 7 8 2.3 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C 10.1021/jm0000416
15297880 121318 0 None - 1 Mouse 5.3 pKi = 5.3 Binding
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 433 4 2 2 5.1 O=C(O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCc1ccc2ccccc2c1 10.1021/jm00048a001
CHEMBL333664 121318 0 None - 1 Mouse 5.3 pKi = 5.3 Binding
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 433 4 2 2 5.1 O=C(O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCc1ccc2ccccc2c1 10.1021/jm00048a001
44272056 104940 0 None 42 2 Human 7.3 pKi = 7.3 Binding
Displacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranesDisplacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranes
ChEMBL 1194 24 13 13 2.6 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCCNC(=O)CC[C@@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00126a007
CHEMBL273880 104940 0 None 42 2 Human 7.3 pKi = 7.3 Binding
Displacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranesDisplacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranes
ChEMBL 1194 24 13 13 2.6 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCCNC(=O)CC[C@@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00126a007
16731871 173113 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 492 9 2 5 4.6 CCOCCN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL427277 173113 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 492 9 2 5 4.6 CCOCCN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
10601706 20922 0 None - 1 Mouse 5.3 pKi = 5.3 Binding
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 507 6 2 5 3.0 CC(=O)N1[C@H](C(=O)NCC(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2)C(=O)[C@H]1CC(C)(C)C 10.1021/jm000960w
CHEMBL119825 20922 0 None - 1 Mouse 5.3 pKi = 5.3 Binding
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 507 6 2 5 3.0 CC(=O)N1[C@H](C(=O)NCC(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2)C(=O)[C@H]1CC(C)(C)C 10.1021/jm000960w
45486985 204532 0 None 63 2 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation counting
ChEMBL 650 8 3 6 4.5 O=C(N[C@@H](Cc1ccc(F)c(Br)c1)C(=O)O)c1ccc(Br)cc1NS(=O)(=O)c1cccc2nccnc12 10.1016/j.bmcl.2009.09.065
CHEMBL571650 204532 0 None 63 2 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation counting
ChEMBL 650 8 3 6 4.5 O=C(N[C@@H](Cc1ccc(F)c(Br)c1)C(=O)O)c1ccc(Br)cc1NS(=O)(=O)c1cccc2nccnc12 10.1016/j.bmcl.2009.09.065
11700410 205534 0 None 31 2 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation counting
ChEMBL 704 8 3 7 4.4 O=C(N[C@@H](Cc1ccc(F)c(Br)c1)C(=O)O)c1ccc(I)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.065
CHEMBL583035 205534 0 None 31 2 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation counting
ChEMBL 704 8 3 7 4.4 O=C(N[C@@H](Cc1ccc(F)c(Br)c1)C(=O)O)c1ccc(I)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.065
11353036 148199 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 528 4 1 6 3.7 O=C(c1ccc(I)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
CHEMBL384097 148199 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 528 4 1 6 3.7 O=C(c1ccc(I)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
10770670 99268 0 None 301 2 Mouse 8.3 pKi = 8.3 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 663 11 6 6 4.9 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL2067959 99268 0 None 301 2 Mouse 8.3 pKi = 8.3 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 663 11 6 6 4.9 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL24313 99268 0 None 301 2 Mouse 8.3 pKi = 8.3 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 663 11 6 6 4.9 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL3351054 218317 0 None 812 2 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1ccc2ccccc2c1)C(=O)N(C)[C@@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C 10.1021/jm00053a022
11527738 82764 0 None -2 4 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 518 7 2 5 5.2 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
CHEMBL205455 82764 0 None -2 4 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 518 7 2 5 5.2 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
11527738 82764 0 None -2 4 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 518 7 2 5 5.2 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL205455 82764 0 None -2 4 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 518 7 2 5 5.2 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
44346097 174923 0 None - 1 Human 8.3 pKi = 8.3 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 664 11 2 6 6.8 CCOC(=O)CCCOc1ccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)cc1 10.1021/jm990967h
CHEMBL433028 174923 0 None - 1 Human 8.3 pKi = 8.3 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 664 11 2 6 6.8 CCOC(=O)CCCOc1ccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)cc1 10.1021/jm990967h
10770670 99268 0 None 301 2 Mouse 8.3 pKi = 8.3 Binding
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 663 11 6 6 4.9 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm9508907
CHEMBL2067959 99268 0 None 301 2 Mouse 8.3 pKi = 8.3 Binding
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 663 11 6 6 4.9 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm9508907
CHEMBL24313 99268 0 None 301 2 Mouse 8.3 pKi = 8.3 Binding
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 663 11 6 6 4.9 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm9508907
10484529 108210 0 None 707 2 Mouse 8.3 pKi = 8.3 Binding
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 663 11 5 6 5.8 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3ccoc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm9508907
CHEMBL297480 108210 0 None 707 2 Mouse 8.3 pKi = 8.3 Binding
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 663 11 5 6 5.8 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3ccoc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm9508907
11591504 81829 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 504 7 1 5 5.5 COc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
CHEMBL203530 81829 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 504 7 1 5 5.5 COc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
16732018 92243 0 None 741 2 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 548 9 2 6 4.9 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(OCC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL226729 92243 0 None 741 2 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 548 9 2 6 4.9 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(OCC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
16732916 143731 0 None 338 2 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 596 8 2 5 6.3 O=C(CN1N=C(C2CCCCC2)c2ccccc2N(CC(=O)C23CC4CC(CC(C4)C2)C3)C1=O)Nc1cccc(C(=O)O)c1 10.1021/jm070139l
CHEMBL374388 143731 0 None 338 2 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 596 8 2 5 6.3 O=C(CN1N=C(C2CCCCC2)c2ccccc2N(CC(=O)C23CC4CC(CC(C4)C2)C3)C1=O)Nc1cccc(C(=O)O)c1 10.1021/jm070139l
21476261 11067 0 None 169 2 Human 8.3 pKi = 8.3 Binding
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 571 8 2 4 5.9 CC(C)CCN1C(=O)C(NC(=O)Nc2cccc(N(C)C)c2)C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc21 10.1016/S0960-894X(96)00544-6
CHEMBL100776 11067 0 None 169 2 Human 8.3 pKi = 8.3 Binding
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 571 8 2 4 5.9 CC(C)CCN1C(=O)C(NC(=O)Nc2cccc(N(C)C)c2)C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc21 10.1016/S0960-894X(96)00544-6
11605694 175432 0 None 5 3 Mouse 8.2 pKi = 8.2 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 497 7 3 3 6.8 Cc1ccc(NC(=O)c2[nH]c(-c3ccccc3C)nc2CCC23CC4CC(CC(C4)C2)C3)cc1C(=O)O 10.1021/jm0490686
CHEMBL436314 175432 0 None 5 3 Mouse 8.2 pKi = 8.2 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 497 7 3 3 6.8 Cc1ccc(NC(=O)c2[nH]c(-c3ccccc3C)nc2CCC23CC4CC(CC(C4)C2)C3)cc1C(=O)O 10.1021/jm0490686
10031454 115365 0 None 67 2 Human 7.3 pKi = 7.3 Binding
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 596 10 2 4 5.5 CC(Cc1ccc(Br)cc1)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccc1)CC(=O)O 10.1021/jm00072a005
CHEMBL320399 115365 0 None 67 2 Human 7.3 pKi = 7.3 Binding
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 596 10 2 4 5.5 CC(Cc1ccc(Br)cc1)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccc1)CC(=O)O 10.1021/jm00072a005
11534407 203714 0 None -6 2 Human 6.3 pKi = 6.3 Binding
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 584 8 3 7 4.9 O=C(N[C@H](Cc1ccc(Cl)c(Cl)c1)C(=O)O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.064
CHEMBL566359 203714 0 None -6 2 Human 6.3 pKi = 6.3 Binding
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 584 8 3 7 4.9 O=C(N[C@H](Cc1ccc(Cl)c(Cl)c1)C(=O)O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.064
11541048 203754 0 None -7 2 Human 6.3 pKi = 6.3 Binding
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 530 7 2 6 4.8 C[C@H](CNC(=O)c1ccc(Br)cc1NS(=O)(=O)c1cccc2nsnc12)c1ccccc1 10.1016/j.bmcl.2009.09.064
CHEMBL566604 203754 0 None -7 2 Human 6.3 pKi = 6.3 Binding
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 530 7 2 6 4.8 C[C@H](CNC(=O)c1ccc(Br)cc1NS(=O)(=O)c1cccc2nsnc12)c1ccccc1 10.1016/j.bmcl.2009.09.064
11635377 205588 0 None -39 2 Human 6.3 pKi = 6.3 Binding
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 554 7 2 6 6.0 CC(CNC(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2009.09.064
CHEMBL583457 205588 0 None -39 2 Human 6.3 pKi = 6.3 Binding
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 554 7 2 6 6.0 CC(CNC(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2009.09.064
25033380 100933 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 498 5 1 6 3.9 COC(=O)c1c(C)oc(C)c1S(=O)(=O)Nc1cc(Br)ccc1C(=O)N1CCCCC1 10.1016/j.bmcl.2007.09.087
CHEMBL249469 100933 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 498 5 1 6 3.9 COC(=O)c1c(C)oc(C)c1S(=O)(=O)Nc1cc(Br)ccc1C(=O)N1CCCCC1 10.1016/j.bmcl.2007.09.087
24755148 101258 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 458 4 1 3 4.2 O=C(c1ccc(Br)cc1NS(=O)(=O)c1c(F)cccc1F)N1CCCCC1 10.1016/j.bmcl.2007.09.087
CHEMBL251466 101258 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 458 4 1 3 4.2 O=C(c1ccc(Br)cc1NS(=O)(=O)c1c(F)cccc1F)N1CCCCC1 10.1016/j.bmcl.2007.09.087
16090646 89265 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 466 5 1 7 3.8 COc1cc(C(=O)N2CCCCC2)c(NS(=O)(=O)c2cccc3nsnc23)cc1Cl 10.1021/jm060590x
CHEMBL217715 89265 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 466 5 1 7 3.8 COc1cc(C(=O)N2CCCCC2)c(NS(=O)(=O)c2cccc3nsnc23)cc1Cl 10.1021/jm060590x
11202178 148615 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 467 5 1 7 3.9 O=C(c1ccc(-n2cccc2)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
CHEMBL386438 148615 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 467 5 1 7 3.9 O=C(c1ccc(-n2cccc2)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
44451830 164714 1 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [125I]CCK8S from human CCK2RDisplacement of [125I]CCK8S from human CCK2R
ChEMBL 536 6 2 6 4.8 O=C(NCc1ccc(Cl)cc1)c1ccc(Br)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmc.2008.01.059
CHEMBL408452 164714 1 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [125I]CCK8S from human CCK2RDisplacement of [125I]CCK8S from human CCK2R
ChEMBL 536 6 2 6 4.8 O=C(NCc1ccc(Cl)cc1)c1ccc(Br)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmc.2008.01.059
44403982 19050 0 None 7 2 Mouse 6.3 pKi = 6.3 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 677 11 5 6 4.9 CN(C(=O)[C@H](Cc1ccccc1)NC(=O)c1cc2[nH]cnc2cc1C(=O)NCC12CC3CC(CC(C3)C1)C2)c1cc(C(=O)O)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL1184798 19050 0 None 7 2 Mouse 6.3 pKi = 6.3 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 677 11 5 6 4.9 CN(C(=O)[C@H](Cc1ccccc1)NC(=O)c1cc2[nH]cnc2cc1C(=O)NCC12CC3CC(CC(C3)C1)C2)c1cc(C(=O)O)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL2067958 19050 0 None 7 2 Mouse 6.3 pKi = 6.3 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 677 11 5 6 4.9 CN(C(=O)[C@H](Cc1ccccc1)NC(=O)c1cc2[nH]cnc2cc1C(=O)NCC12CC3CC(CC(C3)C1)C2)c1cc(C(=O)O)cc(C(=O)O)c1 10.1021/jm049069y
25033309 101293 0 None - 1 Human 5.3 pKi = 5.3 Binding
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 447 4 1 4 3.7 N#Cc1cccc(S(=O)(=O)Nc2cc(Br)ccc2C(=O)N2CCCCC2)c1 10.1016/j.bmcl.2007.09.087
CHEMBL251652 101293 0 None - 1 Human 5.3 pKi = 5.3 Binding
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 447 4 1 4 3.7 N#Cc1cccc(S(=O)(=O)Nc2cc(Br)ccc2C(=O)N2CCCCC2)c1 10.1016/j.bmcl.2007.09.087
16090782 148744 0 None - 1 Human 5.3 pKi = 5.3 Binding
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 480 4 1 6 3.9 O=C(c1ccc(Br)cc1NS(=O)(=O)c1ccc2nsnc2c1)N1CCCCC1 10.1016/j.bmcl.2007.09.087
CHEMBL387299 148744 0 None - 1 Human 5.3 pKi = 5.3 Binding
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 480 4 1 6 3.9 O=C(c1ccc(Br)cc1NS(=O)(=O)c1ccc2nsnc2c1)N1CCCCC1 10.1016/j.bmcl.2007.09.087
25033226 161545 0 None - 1 Human 5.3 pKi = 5.3 Binding
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 484 5 1 6 3.6 COC(=O)c1cc(S(=O)(=O)Nc2cc(Br)ccc2C(=O)N2CCCCC2)oc1C 10.1016/j.bmcl.2007.09.087
CHEMBL400114 161545 0 None - 1 Human 5.3 pKi = 5.3 Binding
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 484 5 1 6 3.6 COC(=O)c1cc(S(=O)(=O)Nc2cc(Br)ccc2C(=O)N2CCCCC2)oc1C 10.1016/j.bmcl.2007.09.087
24983506 161561 0 None - 1 Human 5.3 pKi = 5.3 Binding
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 516 6 1 7 3.7 COC(=O)c1csc(S(=O)(=O)Nc2cc(Br)ccc2C(=O)N2CCCCC2)c1OC 10.1016/j.bmcl.2007.09.087
CHEMBL400164 161561 0 None - 1 Human 5.3 pKi = 5.3 Binding
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 516 6 1 7 3.7 COC(=O)c1csc(S(=O)(=O)Nc2cc(Br)ccc2C(=O)N2CCCCC2)c1OC 10.1016/j.bmcl.2007.09.087
25033310 161562 0 None - 1 Human 5.3 pKi = 5.3 Binding
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 563 5 1 6 5.6 O=C(c1ccc(Br)cc1NS(=O)(=O)c1ccc(-c2cc(C(F)(F)F)on2)s1)N1CCCCC1 10.1016/j.bmcl.2007.09.087
CHEMBL400165 161562 0 None - 1 Human 5.3 pKi = 5.3 Binding
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 563 5 1 6 5.6 O=C(c1ccc(Br)cc1NS(=O)(=O)c1ccc(-c2cc(C(F)(F)F)on2)s1)N1CCCCC1 10.1016/j.bmcl.2007.09.087
16090695 148273 0 None - 1 Human 5.3 pKi = 5.3 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 460 4 1 6 3.3 C[C@H]1COC[C@H](C)N1C(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nccnc12 10.1021/jm060590x
CHEMBL384457 148273 0 None - 1 Human 5.3 pKi = 5.3 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 460 4 1 6 3.3 C[C@H]1COC[C@H](C)N1C(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nccnc12 10.1021/jm060590x
16090699 148694 0 None -1 2 Human 5.3 pKi = 5.3 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 463 8 4 4 3.4 O=C(N[C@@H](Cc1ccccc1)C(=O)O)c1ccccc1NS(=O)(=O)c1cc2ccccc2[nH]1 10.1021/jm060590x
CHEMBL386985 148694 0 None -1 2 Human 5.3 pKi = 5.3 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 463 8 4 4 3.4 O=C(N[C@@H](Cc1ccccc1)C(=O)O)c1ccccc1NS(=O)(=O)c1cc2ccccc2[nH]1 10.1021/jm060590x
25033065 166921 0 None - 1 Human 5.3 pKi = 5.3 Binding
Displacement of [125I]CCK8S from human CCK2RDisplacement of [125I]CCK8S from human CCK2R
ChEMBL 493 4 1 5 4.8 Cc1nc2cccc(S(=O)(=O)Nc3cc(Br)ccc3C(=O)N3CCCCC3)c2s1 10.1016/j.bmc.2008.01.059
CHEMBL410905 166921 0 None - 1 Human 5.3 pKi = 5.3 Binding
Displacement of [125I]CCK8S from human CCK2RDisplacement of [125I]CCK8S from human CCK2R
ChEMBL 493 4 1 5 4.8 Cc1nc2cccc(S(=O)(=O)Nc3cc(Br)ccc3C(=O)N3CCCCC3)c2s1 10.1016/j.bmc.2008.01.059
118719285 122261 0 None -1 3 Rat 7.3 pKi = 7.3 Binding
Affinity of compound on binding of [3H]pCCK-8 to the cholecystokinin type B receptor in rat brain membraneAffinity of compound on binding of [3H]pCCK-8 to the cholecystokinin type B receptor in rat brain membrane
ChEMBL 733 15 5 7 4.7 CN(C)[C@@H](Cc1cccc2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C)c1ccccc1 10.1021/jm00053a022
CHEMBL3351057 122261 0 None -1 3 Rat 7.3 pKi = 7.3 Binding
Affinity of compound on binding of [3H]pCCK-8 to the cholecystokinin type B receptor in rat brain membraneAffinity of compound on binding of [3H]pCCK-8 to the cholecystokinin type B receptor in rat brain membrane
ChEMBL 733 15 5 7 4.7 CN(C)[C@@H](Cc1cccc2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C)c1ccccc1 10.1021/jm00053a022
10439779 113463 0 None 1 3 Human 7.3 pKi = 7.3 Binding
Inhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptorInhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptor
ChEMBL 710 11 7 8 2.2 C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCSSCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm9603072
CHEMBL3143501 113463 0 None 1 3 Human 7.3 pKi = 7.3 Binding
Inhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptorInhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptor
ChEMBL 710 11 7 8 2.2 C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCSSCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm9603072
9985629 174838 0 None 41 2 Human 7.3 pKi = 7.3 Binding
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 577 8 3 3 6.1 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccc(Br)cc1 10.1021/jm00072a005
CHEMBL432389 174838 0 None 41 2 Human 7.3 pKi = 7.3 Binding
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 577 8 3 3 6.1 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccc(Br)cc1 10.1021/jm00072a005
CHEMBL353862 218507 0 None -1 3 Rat 7.3 pKi = 7.3 Binding
Tested for the inhibition of [3H]pCCK-8 binding to Cholecystokinin type B receptor in rat brain membranesTested for the inhibition of [3H]pCCK-8 binding to Cholecystokinin type B receptor in rat brain membranes
ChEMBL None None None CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)c1ccccc1 10.1016/S0960-894X(00)80678-2
443375 214385 45 None -316 5 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm051219x
CHEMBL9506 214385 45 None -316 5 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm051219x
10698813 18414 0 None - 1 Mouse 6.3 pKi = 6.3 Binding
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 599 7 2 5 4.6 CC(=O)N1[C@H](C(=O)N[C@H](C)C(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
CHEMBL118096 18414 0 None - 1 Mouse 6.3 pKi = 6.3 Binding
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 599 7 2 5 4.6 CC(=O)N1[C@H](C(=O)N[C@H](C)C(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
10579209 117176 0 None - 1 Mouse 5.3 pKi = 5.3 Binding
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 585 7 2 5 4.2 CC(=O)N1[C@@H](CC23CC4CC(CC(C4)C2)C3)C(=O)N(Cc2ccccc2)c2ccccc2C(=O)C[C@@H]1C(=O)NCC(=O)O 10.1021/jm000960w
CHEMBL324367 117176 0 None - 1 Mouse 5.3 pKi = 5.3 Binding
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 585 7 2 5 4.2 CC(=O)N1[C@@H](CC23CC4CC(CC(C4)C2)C3)C(=O)N(Cc2ccccc2)c2ccccc2C(=O)C[C@@H]1C(=O)NCC(=O)O 10.1021/jm000960w
9853654 29561 41 None 31 2 Human 7.3 pKi = 7.3 Binding
Inhibition of binding of [125I]-PD 142251 to CCK-B receptor was determinedInhibition of binding of [125I]-PD 142251 to CCK-B receptor was determined
ChEMBL 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/0960-894X(95)00435-V
CHEMBL1328 29561 41 None 31 2 Human 7.3 pKi = 7.3 Binding
Inhibition of binding of [125I]-PD 142251 to CCK-B receptor was determinedInhibition of binding of [125I]-PD 142251 to CCK-B receptor was determined
ChEMBL 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/0960-894X(95)00435-V
44357208 125761 0 None 4 2 Mouse 6.3 pKi = 6.3 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 737 10 5 5 6.7 O=C(O)c1cc(NC(=O)[C@H](NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)c2ccccc2)cc(C(=O)O)c1 10.1021/jm00021a019
CHEMBL342465 125761 0 None 4 2 Mouse 6.3 pKi = 6.3 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 737 10 5 5 6.7 O=C(O)c1cc(NC(=O)[C@H](NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)c2ccccc2)cc(C(=O)O)c1 10.1021/jm00021a019
10075052 196453 0 None -10 2 Human 6.3 pKi = 6.3 Binding
Displacement of [125I](R)-1-(3-iodophenyl)-3-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1Hbenzo[e][1,4]diazepin-3-yl)urea from human CCK2 receptor expressed in CHO cells by gamma spectrometryDisplacement of [125I](R)-1-(3-iodophenyl)-3-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1Hbenzo[e][1,4]diazepin-3-yl)urea from human CCK2 receptor expressed in CHO cells by gamma spectrometry
ChEMBL 510 3 2 3 4.3 CN1C(=O)[C@H](NC(=O)Nc2cccc(I)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm801439x
CHEMBL515268 196453 0 None -10 2 Human 6.3 pKi = 6.3 Binding
Displacement of [125I](R)-1-(3-iodophenyl)-3-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1Hbenzo[e][1,4]diazepin-3-yl)urea from human CCK2 receptor expressed in CHO cells by gamma spectrometryDisplacement of [125I](R)-1-(3-iodophenyl)-3-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1Hbenzo[e][1,4]diazepin-3-yl)urea from human CCK2 receptor expressed in CHO cells by gamma spectrometry
ChEMBL 510 3 2 3 4.3 CN1C(=O)[C@H](NC(=O)Nc2cccc(I)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm801439x
CHEMBL515288 196453 0 None -10 2 Human 6.3 pKi = 6.3 Binding
Displacement of [125I](R)-1-(3-iodophenyl)-3-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1Hbenzo[e][1,4]diazepin-3-yl)urea from human CCK2 receptor expressed in CHO cells by gamma spectrometryDisplacement of [125I](R)-1-(3-iodophenyl)-3-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1Hbenzo[e][1,4]diazepin-3-yl)urea from human CCK2 receptor expressed in CHO cells by gamma spectrometry
ChEMBL 510 3 2 3 4.3 CN1C(=O)[C@H](NC(=O)Nc2cccc(I)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm801439x
15249830 108712 0 None 15 2 Mouse 6.3 pKi = 6.3 Binding
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 441 4 2 2 4.9 O=C(O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC12CC3CC(CC(C3)C1)C2 10.1021/jm9508907
CHEMBL301095 108712 0 None 15 2 Mouse 6.3 pKi = 6.3 Binding
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 441 4 2 2 4.9 O=C(O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC12CC3CC(CC(C3)C1)C2 10.1021/jm9508907
44347142 120908 0 None 15 2 Mouse 6.3 pKi = 6.3 Binding
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 441 4 2 2 4.8 O=C(O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC1C2CC3CC(C2)CC1C3 10.1021/jm00048a001
CHEMBL332873 120908 0 None 15 2 Mouse 6.3 pKi = 6.3 Binding
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 441 4 2 2 4.8 O=C(O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC1C2CC3CC(C2)CC1C3 10.1021/jm00048a001
CHEMBL3350720 218267 0 None 4 2 Human 7.3 pKi = 7.3 Binding
Apparent affinity to inhibit binding of [3H]pCCK-8 to Cholecystokinin type B receptor of guinea pig brain membranesApparent affinity to inhibit binding of [3H]pCCK-8 to Cholecystokinin type B receptor of guinea pig brain membranes
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(N)=O 10.1021/jm00174a016
CHEMBL216831 216122 0 None 29 2 Human 7.3 pKi = 7.3 Binding
Displacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranesDisplacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranes
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCC)NC(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@@H](CCC(=O)O)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00126a007
44280576 170042 0 None - 1 Rat 6.3 pKi = 6.3 Binding
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 667 8 3 5 6.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1CC[C@@H](Oc2ccc(Cl)cc2Cl)C[C@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
CHEMBL418593 170042 0 None - 1 Rat 6.3 pKi = 6.3 Binding
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 667 8 3 5 6.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1CC[C@@H](Oc2ccc(Cl)cc2Cl)C[C@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
10393515 115483 0 None - 1 Human 6.3 pKi = 6.3 Binding
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 585 11 2 5 5.7 CCOC(=O)CN(CCc1ccccc1)C(=O)C(C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00072a005
CHEMBL320823 115483 0 None - 1 Human 6.3 pKi = 6.3 Binding
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 585 11 2 5 5.7 CCOC(=O)CN(CCc1ccccc1)C(=O)C(C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00072a005
44351415 175168 0 None - 1 Human 7.3 pKi = 7.3 Binding
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 634 9 3 6 5.3 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](OCc2cccc(Cl)c2)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL434631 175168 0 None - 1 Human 7.3 pKi = 7.3 Binding
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 634 9 3 6 5.3 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](OCc2cccc(Cl)c2)C[C@@H]1C(=O)O 10.1021/jm970439a
44408632 165016 0 None -2454 4 Human 6.3 pKi = 6.3 Binding
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1212 31 12 15 3.8 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@H](Cc1cn(C(=O)OC23CC4CC(CC(C4)C2)C3)c2ccccc12)C(=O)O 10.1021/jm050851n
CHEMBL408832 165016 0 None -2454 4 Human 6.3 pKi = 6.3 Binding
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1212 31 12 15 3.8 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@H](Cc1cn(C(=O)OC23CC4CC(CC(C4)C2)C3)c2ccccc12)C(=O)O 10.1021/jm050851n
44580898 195141 0 None -5 2 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]CCK-26-33 from CCK2R-MOPR coexpressed in CHO cellsDisplacement of [125I]CCK-26-33 from CCK2R-MOPR coexpressed in CHO cells
ChEMBL 973 16 8 14 1.0 CN1C(=O)[C@H](NC(=O)Nc2cccc(OCCNC(=O)COCC(=O)NNC(=O)COCC(=O)N[C@H]3CC[C@@]4(O)[C@H]5Cc6cc(O)cc7c6[C@@]4(CCN5C)[C@H]3O7)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm800174p
CHEMBL501238 195141 0 None -5 2 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]CCK-26-33 from CCK2R-MOPR coexpressed in CHO cellsDisplacement of [125I]CCK-26-33 from CCK2R-MOPR coexpressed in CHO cells
ChEMBL 973 16 8 14 1.0 CN1C(=O)[C@H](NC(=O)Nc2cccc(OCCNC(=O)COCC(=O)NNC(=O)COCC(=O)N[C@H]3CC[C@@]4(O)[C@H]5Cc6cc(O)cc7c6[C@@]4(CCN5C)[C@H]3O7)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm800174p
44356888 125647 0 None 35 2 Mouse 7.2 pKi = 7.2 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 765 12 5 5 7.0 O=C(O)c1cc(NC(=O)[C@@H](CCc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm00021a019
CHEMBL342205 125647 0 None 35 2 Mouse 7.2 pKi = 7.2 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 765 12 5 5 7.0 O=C(O)c1cc(NC(=O)[C@@H](CCc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm00021a019
CHEMBL3350331 218252 0 None -1 2 Human 6.2 pKi = 6.2 Binding
Apparent affinity to inhibit binding of [3H]pCCK-8 to Cholecystokinin type B receptor of guinea pig brain membranesApparent affinity to inhibit binding of [3H]pCCK-8 to Cholecystokinin type B receptor of guinea pig brain membranes
ChEMBL None None None CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00174a016
CHEMBL320868 218008 0 None -70 2 Rat 6.2 pKi = 6.2 Binding
Binding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligand
ChEMBL None None None Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm990252e
15513854 121585 0 None - 1 Mouse 6.2 pKi = 6.2 Binding
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 635 7 2 6 5.1 COC(=O)N1[C@H](C(=O)NCC(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2Cl)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
CHEMBL334054 121585 0 None - 1 Mouse 6.2 pKi = 6.2 Binding
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 635 7 2 6 5.1 COC(=O)N1[C@H](C(=O)NCC(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2Cl)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
CHEMBL3351048 218311 0 None 5 2 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL None None None CN(C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1ccccc1)[C@@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C 10.1021/jm00053a022
9984452 36487 0 None - 1 Mouse 8.2 pKi = 8.2 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 529 9 4 4 4.7 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00087a011
CHEMBL138657 36487 0 None - 1 Mouse 8.2 pKi = 8.2 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 529 9 4 4 4.7 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00087a011
11511721 82877 0 None 4 3 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 502 7 2 5 5.5 CNc1cccc(NC(=O)C[C@@H]2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
CHEMBL205751 82877 0 None 4 3 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 502 7 2 5 5.5 CNc1cccc(NC(=O)C[C@@H]2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
11663565 82971 0 None 15 2 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 517 7 1 5 5.5 CN(C)c1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
CHEMBL205831 82971 0 None 15 2 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 517 7 1 5 5.5 CN(C)c1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
16731537 92288 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 571 8 2 6 5.5 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc3c2ccn3CC(=O)O)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL227277 92288 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 571 8 2 6 5.5 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc3c2ccn3CC(=O)O)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
44351469 123713 0 None 2 2 Human 8.2 pKi = 8.2 Binding
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 603 7 3 4 6.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1CC(c2ccc(Cl)cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL338526 123713 0 None 2 2 Human 8.2 pKi = 8.2 Binding
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 603 7 3 4 6.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1CC(c2ccc(Cl)cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL3400294 218408 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of Eu-DTPA-PEGO-CCK4 from human cholecystokinin 2 receptor overexpressed in HEK-293 cells co-expressing human MC4R after 1 hr by time resolved fluorescence-based competition binding assayDisplacement of Eu-DTPA-PEGO-CCK4 from human cholecystokinin 2 receptor overexpressed in HEK-293 cells co-expressing human MC4R after 1 hr by time resolved fluorescence-based competition binding assay
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmc.2015.02.028
10257865 215217 4 None 2 5 Human 8.2 pKi = 8.2 Binding
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 591 10 3 4 5.8 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccc(Cl)cc1)CC(=O)O 10.1021/jm00072a005
CHEMBL99939 215217 4 None 2 5 Human 8.2 pKi = 8.2 Binding
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 591 10 3 4 5.8 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccc(Cl)cc1)CC(=O)O 10.1021/jm00072a005
16733463 20774 0 None 1380 2 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 547 9 3 6 5.0 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(NCC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL1197033 20774 0 None 1380 2 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 547 9 3 6 5.0 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(NCC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL559157 20774 0 None 1380 2 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 547 9 3 6 5.0 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(NCC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
10623068 119618 0 None 89 2 Human 8.2 pKi = 8.2 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 442 6 2 3 4.7 CCCCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21 10.1021/jm990967h
CHEMBL330854 119618 0 None 89 2 Human 8.2 pKi = 8.2 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 442 6 2 3 4.7 CCCCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21 10.1021/jm990967h
45486936 203750 0 None 25 2 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation counting
ChEMBL 640 8 3 6 5.1 O=C(N[C@@H](Cc1ccc(F)c(Br)c1)C(=O)O)c1cc(Cl)c(Cl)cc1NS(=O)(=O)c1cccc2nccnc12 10.1016/j.bmcl.2009.09.065
CHEMBL566574 203750 0 None 25 2 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation counting
ChEMBL 640 8 3 6 5.1 O=C(N[C@@H](Cc1ccc(F)c(Br)c1)C(=O)O)c1cc(Cl)c(Cl)cc1NS(=O)(=O)c1cccc2nccnc12 10.1016/j.bmcl.2009.09.065
45486976 205751 0 None 39 2 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation counting
ChEMBL 656 8 3 7 4.6 O=C(N[C@@H](Cc1ccc(F)c(Br)c1)C(=O)O)c1ccc(Br)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.065
CHEMBL585157 205751 0 None 39 2 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation counting
ChEMBL 656 8 3 7 4.6 O=C(N[C@@H](Cc1ccc(F)c(Br)c1)C(=O)O)c1ccc(Br)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.065
44451622 102691 0 None 4 3 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 562 9 2 5 5.5 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CCC(=O)O)c2)C(=O)N(C2CCCCC2)c2ccccc21 10.1016/j.bmc.2007.12.047
CHEMBL259276 102691 0 None 4 3 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 562 9 2 5 5.5 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CCC(=O)O)c2)C(=O)N(C2CCCCC2)c2ccccc21 10.1016/j.bmc.2007.12.047
44346355 164646 0 None 30 3 Human 8.2 pKi = 8.2 Binding
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 1260 26 13 15 1.7 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CCCCNC(=O)C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc2ccc(OS(=O)(=O)O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm0000416
CHEMBL408389 164646 0 None 30 3 Human 8.2 pKi = 8.2 Binding
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 1260 26 13 15 1.7 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CCCCNC(=O)C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc2ccc(OS(=O)(=O)O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm0000416
CHEMBL2370588 216651 0 None 446 2 Human 8.2 pKi = 8.2 Binding
Displacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranesDisplacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranes
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCCNC(=O)C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc2ccc(OS(=O)(=O)O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccccc1)C(N)=O 10.1021/jm00126a007
10257865 215217 4 None 2 5 Human 8.2 pKi = 8.2 Binding
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 591 10 3 4 5.8 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccc(Cl)cc1)CC(=O)O 10.1021/jm00072a005
CHEMBL99939 215217 4 None 2 5 Human 8.2 pKi = 8.2 Binding
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 591 10 3 4 5.8 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccc(Cl)cc1)CC(=O)O 10.1021/jm00072a005
44351444 123664 0 None -1 2 Human 8.2 pKi = 8.2 Binding
Binding affinity (affinity state 1) for Cholecystokinin type B receptor, was determined using CHO cellsBinding affinity (affinity state 1) for Cholecystokinin type B receptor, was determined using CHO cells
ChEMBL 622 8 3 6 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(F)cc2F)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL338300 123664 0 None -1 2 Human 8.2 pKi = 8.2 Binding
Binding affinity (affinity state 1) for Cholecystokinin type B receptor, was determined using CHO cellsBinding affinity (affinity state 1) for Cholecystokinin type B receptor, was determined using CHO cells
ChEMBL 622 8 3 6 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(F)cc2F)C[C@@H]1C(=O)O 10.1021/jm970439a
11643045 78913 0 None 43 3 Mouse 8.2 pKi = 8.2 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 511 9 3 3 6.8 Cc1ccccc1-c1nc(C(=O)Nc2cccc(CCC(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
CHEMBL197873 78913 0 None 43 3 Mouse 8.2 pKi = 8.2 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 511 9 3 3 6.8 Cc1ccccc1-c1nc(C(=O)Nc2cccc(CCC(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
10793611 22271 0 None 4 2 Human 7.2 pKi = 7.2 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 594 7 2 4 7.2 CSc1cccc(NC(=O)NC2C(=O)N(CCC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 10.1021/jm990967h
CHEMBL121624 22271 0 None 4 2 Human 7.2 pKi = 7.2 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 594 7 2 4 7.2 CSc1cccc(NC(=O)NC2C(=O)N(CCC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 10.1021/jm990967h
CHEMBL1171596 215358 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2010.05.078
14802539 83327 1 None - 1 Mouse 7.2 pKi = 7.2 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 614 12 5 5 4.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1 10.1021/jm00087a011
CHEMBL2062144 83327 1 None - 1 Mouse 7.2 pKi = 7.2 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 614 12 5 5 4.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1 10.1021/jm00087a011
11495719 77148 0 None -30 3 Mouse 6.2 pKi = 6.2 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 431 7 3 3 5.8 Cc1ccccc1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC2CCCCC2)[nH]1 10.1021/jm0490686
CHEMBL194514 77148 0 None -30 3 Mouse 6.2 pKi = 6.2 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 431 7 3 3 5.8 Cc1ccccc1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC2CCCCC2)[nH]1 10.1021/jm0490686
73354642 96233 0 None 2 3 Human 7.2 pKi = 7.2 Binding
Inhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptorInhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptor
ChEMBL 646 11 7 6 1.6 C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm9603072
CHEMBL2371225 96233 0 None 2 3 Human 7.2 pKi = 7.2 Binding
Inhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptorInhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptor
ChEMBL 646 11 7 6 1.6 C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm9603072
443375 214385 45 None -316 5 Human 7.2 pKi = 7.2 Binding
The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80686-1
CHEMBL9506 214385 45 None -316 5 Human 7.2 pKi = 7.2 Binding
The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80686-1
10793449 175442 0 None - 1 Human 6.2 pKi = 6.2 Binding
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 585 8 3 5 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@@H](Oc2ccccc2)C[C@H]1C(=O)O 10.1021/jm970439a
CHEMBL436382 175442 0 None - 1 Human 6.2 pKi = 6.2 Binding
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 585 8 3 5 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@@H](Oc2ccccc2)C[C@H]1C(=O)O 10.1021/jm970439a
10650978 123416 0 None - 1 Human 7.2 pKi = 7.2 Binding
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 585 8 3 5 5.2 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@@H](Oc2ccccc2)C[C@H]1C(=O)O 10.1021/jm970439a
CHEMBL336965 123416 0 None - 1 Human 7.2 pKi = 7.2 Binding
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 585 8 3 5 5.2 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@@H](Oc2ccccc2)C[C@H]1C(=O)O 10.1021/jm970439a
45486940 205664 0 None 31 2 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 550 8 3 7 4.2 O=C(N[C@@H](Cc1ccc(Cl)cc1)C(=O)O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.064
CHEMBL584259 205664 0 None 31 2 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 550 8 3 7 4.2 O=C(N[C@@H](Cc1ccc(Cl)cc1)C(=O)O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.064
11363566 87836 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 476 4 1 6 2.7 O=C(c1ccc(Br)cc1NS(=O)(=O)c1cccc2nccnc12)N1CCOCC1 10.1021/jm060590x
CHEMBL215416 87836 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 476 4 1 6 2.7 O=C(c1ccc(Br)cc1NS(=O)(=O)c1cccc2nccnc12)N1CCOCC1 10.1021/jm060590x
11385416 89268 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 450 4 1 6 4.2 O=C(c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCCC1 10.1021/jm060590x
CHEMBL217720 89268 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 450 4 1 6 4.2 O=C(c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCCC1 10.1021/jm060590x
16090797 89357 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 512 5 1 6 5.2 O=C(c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCC(c2ccccc2)CC1 10.1021/jm060590x
CHEMBL217878 89357 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 512 5 1 6 5.2 O=C(c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCC(c2ccccc2)CC1 10.1021/jm060590x
44417427 103402 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 475 4 1 6 3.2 O=C(c1ccc(Br)nc1NS(=O)(=O)c1cccc2nccnc12)N1CCCCC1 10.1021/jm060590x
CHEMBL263475 103402 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 475 4 1 6 3.2 O=C(c1ccc(Br)nc1NS(=O)(=O)c1cccc2nccnc12)N1CCCCC1 10.1021/jm060590x
11454197 148642 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 470 4 1 6 4.1 O=C(c1ccc(C(F)(F)F)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
CHEMBL386598 148642 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 470 4 1 6 4.1 O=C(c1ccc(C(F)(F)F)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
11465671 103145 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]CCK8S from human CCK2RDisplacement of [125I]CCK8S from human CCK2R
ChEMBL 474 4 1 5 3.8 O=C(c1ccc(Br)cc1NS(=O)(=O)c1cccc2nccnc12)N1CCCCC1 10.1016/j.bmc.2008.01.059
CHEMBL261682 103145 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]CCK8S from human CCK2RDisplacement of [125I]CCK8S from human CCK2R
ChEMBL 474 4 1 5 3.8 O=C(c1ccc(Br)cc1NS(=O)(=O)c1cccc2nccnc12)N1CCCCC1 10.1016/j.bmc.2008.01.059
45486941 203543 0 None -1 2 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 516 7 2 6 4.2 O=C(NCCc1ccccc1)c1ccc(Br)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.064
CHEMBL565325 203543 0 None -1 2 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 516 7 2 6 4.2 O=C(NCCc1ccccc1)c1ccc(Br)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.064
45486968 204248 0 None -1 2 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 550 8 3 7 4.2 O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.064
CHEMBL569848 204248 0 None -1 2 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 550 8 3 7 4.2 O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.064
11627917 204309 0 None -7 2 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 530 7 2 6 4.8 CC(CNC(=O)c1ccc(Br)cc1NS(=O)(=O)c1cccc2nsnc12)c1ccccc1 10.1016/j.bmcl.2009.09.064
CHEMBL570163 204309 0 None -7 2 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 530 7 2 6 4.8 CC(CNC(=O)c1ccc(Br)cc1NS(=O)(=O)c1cccc2nsnc12)c1ccccc1 10.1016/j.bmcl.2009.09.064
25033224 101259 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 524 4 1 3 5.5 O=C(c1ccc(Br)cc1NS(=O)(=O)c1ccc(C(F)(F)F)cc1Cl)N1CCCCC1 10.1016/j.bmcl.2007.09.087
CHEMBL251467 101259 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 524 4 1 3 5.5 O=C(c1ccc(Br)cc1NS(=O)(=O)c1ccc(C(F)(F)F)cc1Cl)N1CCCCC1 10.1016/j.bmcl.2007.09.087
11316421 89175 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 432 5 1 7 3.1 COc1ccc(C(=O)N2CCCCC2)c(NS(=O)(=O)c2cccc3nsnc23)c1 10.1021/jm060590x
CHEMBL217270 89175 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 432 5 1 7 3.1 COc1ccc(C(=O)N2CCCCC2)c(NS(=O)(=O)c2cccc3nsnc23)c1 10.1021/jm060590x
16090653 89192 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 460 4 1 6 3.3 C[C@H]1COC[C@@H](C)N1C(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nccnc12 10.1021/jm060590x
CHEMBL217373 89192 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 460 4 1 6 3.3 C[C@H]1COC[C@@H](C)N1C(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nccnc12 10.1021/jm060590x
44404001 18705 0 None 6 2 Mouse 6.2 pKi = 6.2 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 635 11 6 6 4.5 O=C(NCC12CC3CC(CC(C3)C1)C2)c1cc2nc[nH]c2cc1C(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1cc(CO)cc(CO)c1 10.1021/jm049069y
CHEMBL1182744 18705 0 None 6 2 Mouse 6.2 pKi = 6.2 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 635 11 6 6 4.5 O=C(NCC12CC3CC(CC(C3)C1)C2)c1cc2nc[nH]c2cc1C(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1cc(CO)cc(CO)c1 10.1021/jm049069y
CHEMBL2067969 18705 0 None 6 2 Mouse 6.2 pKi = 6.2 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 635 11 6 6 4.5 O=C(NCC12CC3CC(CC(C3)C1)C2)c1cc2nc[nH]c2cc1C(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1cc(CO)cc(CO)c1 10.1021/jm049069y
11535277 19051 0 None 10 2 Mouse 6.2 pKi = 6.2 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 513 8 4 4 5.9 O=C(O)c1cc(NC(=O)c2[nH]c(-c3ccccc3)nc2CCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL1184817 19051 0 None 10 2 Mouse 6.2 pKi = 6.2 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 513 8 4 4 5.9 O=C(O)c1cc(NC(=O)c2[nH]c(-c3ccccc3)nc2CCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL2067964 19051 0 None 10 2 Mouse 6.2 pKi = 6.2 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 513 8 4 4 5.9 O=C(O)c1cc(NC(=O)c2[nH]c(-c3ccccc3)nc2CCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm049069y
45486967 204202 0 None -39 2 Human 5.2 pKi = 5.2 Binding
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 472 7 2 6 4.1 O=C(NCCc1ccccc1)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.064
CHEMBL569616 204202 0 None -39 2 Human 5.2 pKi = 5.2 Binding
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 472 7 2 6 4.1 O=C(NCCc1ccccc1)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.064
44445283 100931 0 None - 1 Human 5.2 pKi = 5.2 Binding
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 561 7 2 5 4.9 O=C(NCc1ccc(S(=O)(=O)Nc2cc(Br)ccc2C(=O)N2CCCCC2)s1)c1ccccc1 10.1016/j.bmcl.2007.09.087
CHEMBL249452 100931 0 None - 1 Human 5.2 pKi = 5.2 Binding
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 561 7 2 5 4.9 O=C(NCc1ccc(S(=O)(=O)Nc2cc(Br)ccc2C(=O)N2CCCCC2)s1)c1ccccc1 10.1016/j.bmcl.2007.09.087
11568611 78754 0 None -6 3 Mouse 7.2 pKi = 7.2 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 449 6 3 3 5.8 CC(C)(C)c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
CHEMBL197370 78754 0 None -6 3 Mouse 7.2 pKi = 7.2 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 449 6 3 3 5.8 CC(C)(C)c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
CHEMBL3351051 218314 0 None 17 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1cccc2ccccc12)NC)C(=O)N(C)[C@@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C 10.1021/jm00053a022
4595 183494 106 None -6 14 Rat 6.2 pKi = 6.2 Binding
The binding affinity was measured on cholecystokinin type B receptor using [3H]- CCK-8 as radioligand.The binding affinity was measured on cholecystokinin type B receptor using [3H]- CCK-8 as radioligand.
ChEMBL 293 2 0 4 3.1 Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O 10.1021/jm00075a026
CHEMBL46 183494 106 None -6 14 Rat 6.2 pKi = 6.2 Binding
The binding affinity was measured on cholecystokinin type B receptor using [3H]- CCK-8 as radioligand.The binding affinity was measured on cholecystokinin type B receptor using [3H]- CCK-8 as radioligand.
ChEMBL 293 2 0 4 3.1 Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O 10.1021/jm00075a026
46235271 80423 2 None -2 2 Human 7.2 pKi = 7.2 Binding
Displacement of [125I-BDZ-2] from wild-type human CCK2R at allosteric site expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-BDZ-2] from wild-type human CCK2R at allosteric site expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 649 7 1 6 6.7 Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 10.1021/acs.jmedchem.5b01110
CHEMBL2017835 80423 2 None -2 2 Human 7.2 pKi = 7.2 Binding
Displacement of [125I-BDZ-2] from wild-type human CCK2R at allosteric site expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-BDZ-2] from wild-type human CCK2R at allosteric site expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 649 7 1 6 6.7 Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 10.1021/acs.jmedchem.5b01110
9867157 107018 7 None -194 2 Mouse 4.2 pKi = 4.2 Binding
Compound was evaluated for its affinity against Cholecystokinin type B receptor in mouse cerebral cortexCompound was evaluated for its affinity against Cholecystokinin type B receptor in mouse cerebral cortex
ChEMBL 426 9 3 4 2.3 O=C(O)C[C@H](NS(=O)(=O)c1ccc2ccccc2c1)C(=O)NCCc1ccccc1 10.1016/S0960-894X(00)80008-6
CHEMBL288641 107018 7 None -194 2 Mouse 4.2 pKi = 4.2 Binding
Compound was evaluated for its affinity against Cholecystokinin type B receptor in mouse cerebral cortexCompound was evaluated for its affinity against Cholecystokinin type B receptor in mouse cerebral cortex
ChEMBL 426 9 3 4 2.3 O=C(O)C[C@H](NS(=O)(=O)c1ccc2ccccc2c1)C(=O)NCCc1ccccc1 10.1016/S0960-894X(00)80008-6
108187 7713 37 None -295 5 Rat 8.1 pKi = 8.1 Binding
Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm970439a
873 7713 37 None -295 5 Rat 8.1 pKi = 8.1 Binding
Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm970439a
CHEMBL2062154 7713 37 None -295 5 Rat 8.1 pKi = 8.1 Binding
Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm970439a
CHEMBL287735 7713 37 None -295 5 Rat 8.1 pKi = 8.1 Binding
Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm970439a
44580899 195854 0 None -4 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]DAMGO from CCK2R-MOPR coexpressed in CHO cellsDisplacement of [3H]DAMGO from CCK2R-MOPR coexpressed in CHO cells
ChEMBL 1001 19 8 14 1.1 CN1C(=O)[C@H](NC(=O)Nc2cccc(OCCNC(=O)COCC(=O)NCCNC(=O)COCC(=O)N[C@H]3CC[C@@]4(O)[C@H]5Cc6cc(O)cc7c6[C@@]4(CCN5C)[C@H]3O7)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm800174p
CHEMBL509792 195854 0 None -4 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]DAMGO from CCK2R-MOPR coexpressed in CHO cellsDisplacement of [3H]DAMGO from CCK2R-MOPR coexpressed in CHO cells
ChEMBL 1001 19 8 14 1.1 CN1C(=O)[C@H](NC(=O)Nc2cccc(OCCNC(=O)COCC(=O)NCCNC(=O)COCC(=O)N[C@H]3CC[C@@]4(O)[C@H]5Cc6cc(O)cc7c6[C@@]4(CCN5C)[C@H]3O7)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm800174p
CHEMBL330785 218114 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CC(=O)O)NC(=O)OC(C)(C)C 10.1021/jm0000416
10676212 122787 0 None 489 2 Mouse 8.1 pKi = 8.1 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 701 8 4 5 5.9 O=C(O)c1cc(NC(=O)[C@H]2CCCN2C(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm00021a019
CHEMBL335587 122787 0 None 489 2 Mouse 8.1 pKi = 8.1 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 701 8 4 5 5.9 O=C(O)c1cc(NC(=O)[C@H]2CCCN2C(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm00021a019
44451519 102532 0 None 58 2 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 518 6 1 4 6.1 Cc1cccc(NC(=O)CN2C(=O)N(CC(=O)C(C)(C)C)c3ccccc3N(C3CCCCCC3)C2=O)c1 10.1016/j.bmc.2007.12.047
CHEMBL258486 102532 0 None 58 2 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 518 6 1 4 6.1 Cc1cccc(NC(=O)CN2C(=O)N(CC(=O)C(C)(C)C)c3ccccc3N(C3CCCCCC3)C2=O)c1 10.1016/j.bmc.2007.12.047
16732753 150764 0 None 1 3 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 552 8 2 5 5.7 Cc1ccccc1C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL390276 150764 0 None 1 3 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 552 8 2 5 5.7 Cc1ccccc1C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
44212230 11032 0 None 208 2 Human 8.1 pKi = 8.1 Binding
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 572 8 1 5 5.9 CC(C)CCN1C(=O)C(NC(=O)Oc2cccc(N(C)C)c2)C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc21 10.1016/S0960-894X(96)00544-6
CHEMBL100509 11032 0 None 208 2 Human 8.1 pKi = 8.1 Binding
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 572 8 1 5 5.9 CC(C)CCN1C(=O)C(NC(=O)Oc2cccc(N(C)C)c2)C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc21 10.1016/S0960-894X(96)00544-6
9986662 108805 10 None 977 2 Mouse 8.1 pKi = 8.1 Binding
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 643 11 6 6 4.8 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2F)NC(=O)c2cc3[nH]cnc3cc2C(=O)NCC2CCCCCC2)cc(C(=O)O)c1 10.1021/jm9508907
CHEMBL301777 108805 10 None 977 2 Mouse 8.1 pKi = 8.1 Binding
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 643 11 6 6 4.8 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2F)NC(=O)c2cc3[nH]cnc3cc2C(=O)NCC2CCCCCC2)cc(C(=O)O)c1 10.1021/jm9508907
CHEMBL120452 215381 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(=O)O)NC(=O)OC(C)(C)C 10.1021/jm0000416
5311201 214174 35 None -27 6 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm051219x
CHEMBL9387 214174 35 None -27 6 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm051219x
10695854 120780 0 None 25 2 Human 8.1 pKi = 8.1 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 474 6 2 3 5.1 CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2F)c2ccccc21 10.1021/jm990967h
CHEMBL332646 120780 0 None 25 2 Human 8.1 pKi = 8.1 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 474 6 2 3 5.1 CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2F)c2ccccc21 10.1021/jm990967h
145978895 173244 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of non-sulfated CCK-8 from CCKB receptor (unknown origin) expressed in HEK cells after 4 hrs by RP-LC-ICPMS analysisDisplacement of non-sulfated CCK-8 from CCKB receptor (unknown origin) expressed in HEK cells after 4 hrs by RP-LC-ICPMS analysis
ChEMBL 1063 32 12 10 0.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCCNC(=O)[C@H](CCCNC(=N)N)NC(=O)C[Se]c1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01320
CHEMBL4278080 173244 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of non-sulfated CCK-8 from CCKB receptor (unknown origin) expressed in HEK cells after 4 hrs by RP-LC-ICPMS analysisDisplacement of non-sulfated CCK-8 from CCKB receptor (unknown origin) expressed in HEK cells after 4 hrs by RP-LC-ICPMS analysis
ChEMBL 1063 32 12 10 0.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCCNC(=O)[C@H](CCCNC(=N)N)NC(=O)C[Se]c1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01320
10795162 125816 0 None 630 2 Mouse 8.1 pKi = 8.1 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 751 11 5 5 6.6 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm00021a019
CHEMBL2067970 125816 0 None 630 2 Mouse 8.1 pKi = 8.1 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 751 11 5 5 6.6 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm00021a019
CHEMBL342616 125816 0 None 630 2 Mouse 8.1 pKi = 8.1 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 751 11 5 5 6.6 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm00021a019
11605814 82203 0 None -6 2 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 503 7 2 5 5.5 CNc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
CHEMBL204154 82203 0 None -6 2 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 503 7 2 5 5.5 CNc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
10818497 32624 0 None 58 2 Mouse 7.2 pKi = 7.2 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 701 8 4 5 5.9 O=C(O)c1cc(NC(=O)[C@@H]2CCCN2C(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm00021a019
CHEMBL135344 32624 0 None 58 2 Mouse 7.2 pKi = 7.2 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 701 8 4 5 5.9 O=C(O)c1cc(NC(=O)[C@@H]2CCCN2C(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm00021a019
44357069 162472 0 None 147 2 Mouse 7.2 pKi = 7.2 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 675 9 5 5 5.4 C[C@@H](NC(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC12CC3CC(CC(C3)C1)C2)C(=O)Nc1cc(C(=O)O)cc(C(=O)O)c1 10.1021/jm00021a019
CHEMBL405062 162472 0 None 147 2 Mouse 7.2 pKi = 7.2 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 675 9 5 5 5.4 C[C@@H](NC(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC12CC3CC(CC(C3)C1)C2)C(=O)Nc1cc(C(=O)O)cc(C(=O)O)c1 10.1021/jm00021a019
52949124 7663 4 None 2 2 Human 7.2 pKi = 7.2 Binding
Displacement of [125I-CCK] from wild-type human CCK2R at allosteric site expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-CCK] from wild-type human CCK2R at allosteric site expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
9055 7663 4 None 2 2 Human 7.2 pKi = 7.2 Binding
Displacement of [125I-CCK] from wild-type human CCK2R at allosteric site expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-CCK] from wild-type human CCK2R at allosteric site expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
CHEMBL1269258 7663 4 None 2 2 Human 7.2 pKi = 7.2 Binding
Displacement of [125I-CCK] from wild-type human CCK2R at allosteric site expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-CCK] from wild-type human CCK2R at allosteric site expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
DB12694 7663 4 None 2 2 Human 7.2 pKi = 7.2 Binding
Displacement of [125I-CCK] from wild-type human CCK2R at allosteric site expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-CCK] from wild-type human CCK2R at allosteric site expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
10072464 116523 0 None - 1 Human 4.2 pKi = 4.2 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 450 8 4 4 2.8 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80669-1
CHEMBL32301 116523 0 None - 1 Human 4.2 pKi = 4.2 Binding
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 450 8 4 4 2.8 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80669-1
44580899 195854 0 None -4 2 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]CCK-26-33 from CCK2 receptor expressed in CHO cellsDisplacement of [125I]CCK-26-33 from CCK2 receptor expressed in CHO cells
ChEMBL 1001 19 8 14 1.1 CN1C(=O)[C@H](NC(=O)Nc2cccc(OCCNC(=O)COCC(=O)NCCNC(=O)COCC(=O)N[C@H]3CC[C@@]4(O)[C@H]5Cc6cc(O)cc7c6[C@@]4(CCN5C)[C@H]3O7)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm800174p
CHEMBL509792 195854 0 None -4 2 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]CCK-26-33 from CCK2 receptor expressed in CHO cellsDisplacement of [125I]CCK-26-33 from CCK2 receptor expressed in CHO cells
ChEMBL 1001 19 8 14 1.1 CN1C(=O)[C@H](NC(=O)Nc2cccc(OCCNC(=O)COCC(=O)NCCNC(=O)COCC(=O)N[C@H]3CC[C@@]4(O)[C@H]5Cc6cc(O)cc7c6[C@@]4(CCN5C)[C@H]3O7)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm800174p
16100407 89446 0 None -112 3 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1132 28 13 13 1.7 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc1cc2ccccc2[nH]1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061268p
CHEMBL217957 89446 0 None -112 3 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1132 28 13 13 1.7 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc1cc2ccccc2[nH]1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061268p
CHEMBL3351050 218313 0 None 33 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL None None None CC(C)(C)OC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1cccc2ccccc12 10.1021/jm00053a022
CHEMBL171594 215627 0 None 33 2 Human 7.2 pKi = 7.2 Binding
Tested for the inhibition of [3H]pCCK-8 to Cholecystokinin type B receptor in guinea pig brainTested for the inhibition of [3H]pCCK-8 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL None None None CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O 10.1016/S0960-894X(00)80678-2
10482868 114181 0 None -5 5 Mouse 7.1 pKi = 7.1 Binding
Tested for binding affinity towards cholecystokinin type B receptor in mouse brain by displacement of [3H]pBC264 radioligandTested for binding affinity towards cholecystokinin type B receptor in mouse brain by displacement of [3H]pBC264 radioligand
ChEMBL 557 10 3 4 5.2 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccc1)CC(=O)O 10.1021/jm00072a005
CHEMBL317999 114181 0 None -5 5 Mouse 7.1 pKi = 7.1 Binding
Tested for binding affinity towards cholecystokinin type B receptor in mouse brain by displacement of [3H]pBC264 radioligandTested for binding affinity towards cholecystokinin type B receptor in mouse brain by displacement of [3H]pBC264 radioligand
ChEMBL 557 10 3 4 5.2 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccc1)CC(=O)O 10.1021/jm00072a005
118719284 122260 0 None 72 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL 739 15 5 7 4.9 CN(C)[C@@H](Cc1cccc2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C)C1CCCCC1 10.1021/jm00053a022
CHEMBL3351056 122260 0 None 72 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL 739 15 5 7 4.9 CN(C)[C@@H](Cc1cccc2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C)C1CCCCC1 10.1021/jm00053a022
11663308 83520 1 None 1 2 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 497 7 2 5 5.0 CNc1cccc(NC(=O)CN2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
CHEMBL206709 83520 1 None 1 2 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 497 7 2 5 5.0 CNc1cccc(NC(=O)CN2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
44351454 123596 0 None -1 2 Rat 7.1 pKi = 7.1 Binding
Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.
ChEMBL 712 8 3 6 5.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(I)cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL337933 123596 0 None -1 2 Rat 7.1 pKi = 7.1 Binding
Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.
ChEMBL 712 8 3 6 5.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(I)cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
10604230 121990 0 None 5 2 Mouse 6.1 pKi = 6.1 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 645 10 4 4 4.8 O=C(O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC12CC3CC(CC(C3)C1)C2 10.1021/jm00021a019
CHEMBL334523 121990 0 None 5 2 Mouse 6.1 pKi = 6.1 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 645 10 4 4 4.8 O=C(O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC12CC3CC(CC(C3)C1)C2 10.1021/jm00021a019
44351446 162920 0 None 3 2 Human 7.1 pKi = 7.1 Binding
Binding affinity (affinity state 2) for Cholecystokinin type B receptor, was determined using CHO cellsBinding affinity (affinity state 2) for Cholecystokinin type B receptor, was determined using CHO cells
ChEMBL 631 9 3 8 4.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc([N+](=O)[O-])cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL406359 162920 0 None 3 2 Human 7.1 pKi = 7.1 Binding
Binding affinity (affinity state 2) for Cholecystokinin type B receptor, was determined using CHO cellsBinding affinity (affinity state 2) for Cholecystokinin type B receptor, was determined using CHO cells
ChEMBL 631 9 3 8 4.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc([N+](=O)[O-])cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
15297879 121232 0 None - 1 Mouse 5.1 pKi = 5.1 Binding
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 436 5 3 2 4.4 O=C(O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCCc1c[nH]c2ccccc12 10.1021/jm00048a001
CHEMBL333409 121232 0 None - 1 Mouse 5.1 pKi = 5.1 Binding
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 436 5 3 2 4.4 O=C(O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCCc1c[nH]c2ccccc12 10.1021/jm00048a001
44580900 195219 0 None -2 2 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]CCK-26-33 from CCK2R-MOPR coexpressed in CHO cellsDisplacement of [125I]CCK-26-33 from CCK2R-MOPR coexpressed in CHO cells
ChEMBL 1057 23 8 14 2.6 CN1C(=O)[C@H](NC(=O)Nc2cccc(OCCNC(=O)COCC(=O)NCCCCCCNC(=O)COCC(=O)N[C@H]3CC[C@@]4(O)[C@H]5Cc6cc(O)cc7c6[C@@]4(CCN5C)[C@H]3O7)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm800174p
CHEMBL502398 195219 0 None -2 2 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]CCK-26-33 from CCK2R-MOPR coexpressed in CHO cellsDisplacement of [125I]CCK-26-33 from CCK2R-MOPR coexpressed in CHO cells
ChEMBL 1057 23 8 14 2.6 CN1C(=O)[C@H](NC(=O)Nc2cccc(OCCNC(=O)COCC(=O)NCCCCCCNC(=O)COCC(=O)N[C@H]3CC[C@@]4(O)[C@H]5Cc6cc(O)cc7c6[C@@]4(CCN5C)[C@H]3O7)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm800174p
CHEMBL3351061 218321 0 None 4 2 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL None None None CN(C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1cccc2ccccc12)[C@@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C 10.1021/jm00053a022
16100410 148576 0 None -7079 4 Human 5.1 pKi = 5.1 Binding
Displacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1031 27 13 12 0.2 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@H](Cc1cc2ccccc2[nH]1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061268p
CHEMBL386212 148576 0 None -7079 4 Human 5.1 pKi = 5.1 Binding
Displacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1031 27 13 12 0.2 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@H](Cc1cc2ccccc2[nH]1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061268p
44351413 24922 0 None - 1 Human 6.1 pKi = 6.1 Binding
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 636 8 3 6 5.7 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2cccc3ccccc23)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL126957 24922 0 None - 1 Human 6.1 pKi = 6.1 Binding
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 636 8 3 6 5.7 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2cccc3ccccc23)C[C@@H]1C(=O)O 10.1021/jm970439a
11541870 78226 0 None -10 3 Mouse 6.1 pKi = 6.1 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 433 7 3 3 5.4 O=C(O)c1cccc(NC(=O)c2[nH]c(C3CC3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
CHEMBL196141 78226 0 None -10 3 Mouse 6.1 pKi = 6.1 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 433 7 3 3 5.4 O=C(O)c1cccc(NC(=O)c2[nH]c(C3CC3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
44346825 121551 0 None 77 2 Mouse 6.1 pKi = 6.1 Binding
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 623 8 3 4 4.7 C[C@@H](NC(=O)C[C@@H]1CCCN1C(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC1C2CC3CC(C2)CC1C3)C(=O)O 10.1021/jm00048a001
CHEMBL333920 121551 0 None 77 2 Mouse 6.1 pKi = 6.1 Binding
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 623 8 3 4 4.7 C[C@@H](NC(=O)C[C@@H]1CCCN1C(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC1C2CC3CC(C2)CC1C3)C(=O)O 10.1021/jm00048a001
44280155 109685 0 None - 1 Rat 6.1 pKi = 6.1 Binding
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 667 8 3 5 6.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1CC[C@@H](Oc2ccc(Cl)cc2Cl)C[C@@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
CHEMBL30605 109685 0 None - 1 Rat 6.1 pKi = 6.1 Binding
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 667 8 3 5 6.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1CC[C@@H](Oc2ccc(Cl)cc2Cl)C[C@@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
10325110 118764 0 None 29 2 Human 7.1 pKi = 7.1 Binding
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 544 9 3 5 5.3 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccc([N+](=O)[O-])cc1 10.1021/jm00072a005
CHEMBL328852 118764 0 None 29 2 Human 7.1 pKi = 7.1 Binding
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 544 9 3 5 5.3 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccc([N+](=O)[O-])cc1 10.1021/jm00072a005
45486949 203724 0 None 50 2 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 516 8 3 7 3.6 O=C(N[C@@H](Cc1ccccc1)C(=O)O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.064
CHEMBL566390 203724 0 None 50 2 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 516 8 3 7 3.6 O=C(N[C@@H](Cc1ccccc1)C(=O)O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.064
11464858 88349 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 440 4 1 7 3.3 O=C(c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCSC1 10.1021/jm060590x
CHEMBL216233 88349 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 440 4 1 7 3.3 O=C(c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCSC1 10.1021/jm060590x
25033148 102796 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]CCK8S from human CCK2RDisplacement of [125I]CCK8S from human CCK2R
ChEMBL 479 4 1 5 4.5 O=C(c1ccc(Br)cc1NS(=O)(=O)c1cccc2scnc12)N1CCCCC1 10.1016/j.bmc.2008.01.059
CHEMBL259762 102796 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]CCK8S from human CCK2RDisplacement of [125I]CCK8S from human CCK2R
ChEMBL 479 4 1 5 4.5 O=C(c1ccc(Br)cc1NS(=O)(=O)c1cccc2scnc12)N1CCCCC1 10.1016/j.bmc.2008.01.059
44280575 103439 0 None - 1 Rat 6.1 pKi = 6.1 Binding
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 667 8 3 5 6.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1CC[C@H](Oc2ccc(Cl)cc2Cl)C[C@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
CHEMBL263803 103439 0 None - 1 Rat 6.1 pKi = 6.1 Binding
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 667 8 3 5 6.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1CC[C@H](Oc2ccc(Cl)cc2Cl)C[C@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
11801461 123763 0 None - 1 Human 6.1 pKi = 6.1 Binding
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 585 8 3 5 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccccc2)C[C@H]1C(=O)O 10.1021/jm970439a
CHEMBL338752 123763 0 None - 1 Human 6.1 pKi = 6.1 Binding
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 585 8 3 5 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccccc2)C[C@H]1C(=O)O 10.1021/jm970439a
10698109 114073 0 None -5 2 Human 6.1 pKi = 6.1 Binding
Binding affinity at human CCK2 receptorBinding affinity at human CCK2 receptor
ChEMBL 560 8 1 4 5.8 CC(C)N(C(=O)CN1C(=O)C(CC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1016/j.bmc.2007.12.047
CHEMBL317181 114073 0 None -5 2 Human 6.1 pKi = 6.1 Binding
Binding affinity at human CCK2 receptorBinding affinity at human CCK2 receptor
ChEMBL 560 8 1 4 5.8 CC(C)N(C(=O)CN1C(=O)C(CC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1016/j.bmc.2007.12.047
25033225 101261 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 540 4 1 4 5.4 O=C(c1ccc(Br)cc1NS(=O)(=O)c1sc(Cl)cc1Br)N1CCCCC1 10.1016/j.bmcl.2007.09.087
CHEMBL251486 101261 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 540 4 1 4 5.4 O=C(c1ccc(Br)cc1NS(=O)(=O)c1sc(Cl)cc1Br)N1CCCCC1 10.1016/j.bmcl.2007.09.087
11271596 89056 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 480 4 1 6 3.9 O=C(c1cc(Br)ccc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
CHEMBL217169 89056 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 480 4 1 6 3.9 O=C(c1cc(Br)ccc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
11442229 148574 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 446 4 1 6 2.9 C[C@H]1COCCN1C(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nccnc12 10.1021/jm060590x
CHEMBL386209 148574 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 446 4 1 6 2.9 C[C@H]1COCCN1C(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nccnc12 10.1021/jm060590x
16090784 148692 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 473 4 1 4 4.4 O=C(c1ccc(Br)cc1NS(=O)(=O)c1cccc2ncccc12)N1CCCCC1 10.1021/jm060590x
CHEMBL386976 148692 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 473 4 1 4 4.4 O=C(c1ccc(Br)cc1NS(=O)(=O)c1cccc2ncccc12)N1CCCCC1 10.1021/jm060590x
25032468 103136 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [125I]CCK8S from human CCK2RDisplacement of [125I]CCK8S from human CCK2R
ChEMBL 477 4 1 6 3.2 Cn1nc2cccc(S(=O)(=O)Nc3cc(Br)ccc3C(=O)N3CCCCC3)c2n1 10.1016/j.bmc.2008.01.059
CHEMBL261636 103136 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [125I]CCK8S from human CCK2RDisplacement of [125I]CCK8S from human CCK2R
ChEMBL 477 4 1 6 3.2 Cn1nc2cccc(S(=O)(=O)Nc3cc(Br)ccc3C(=O)N3CCCCC3)c2n1 10.1016/j.bmc.2008.01.059
16090784 148692 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [125I]CCK8S from human CCK2RDisplacement of [125I]CCK8S from human CCK2R
ChEMBL 473 4 1 4 4.4 O=C(c1ccc(Br)cc1NS(=O)(=O)c1cccc2ncccc12)N1CCCCC1 10.1016/j.bmc.2008.01.059
CHEMBL386976 148692 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [125I]CCK8S from human CCK2RDisplacement of [125I]CCK8S from human CCK2R
ChEMBL 473 4 1 4 4.4 O=C(c1ccc(Br)cc1NS(=O)(=O)c1cccc2ncccc12)N1CCCCC1 10.1016/j.bmc.2008.01.059
25033150 166695 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [125I]CCK8S from human CCK2RDisplacement of [125I]CCK8S from human CCK2R
ChEMBL 479 4 1 5 4.5 O=C(c1ccc(Br)cc1NS(=O)(=O)c1cccc2ncsc12)N1CCCCC1 10.1016/j.bmc.2008.01.059
CHEMBL410708 166695 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [125I]CCK8S from human CCK2RDisplacement of [125I]CCK8S from human CCK2R
ChEMBL 479 4 1 5 4.5 O=C(c1ccc(Br)cc1NS(=O)(=O)c1cccc2ncsc12)N1CCCCC1 10.1016/j.bmc.2008.01.059
9869202 78851 0 None 3 2 Mouse 6.1 pKi = 6.1 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 467 6 3 3 6.7 O=C(O)c1cccc(NC(=O)c2[nH]c(-c3ccc4ccccc4c3)nc2CC2CCCCCC2)c1 10.1021/jm049069y
CHEMBL197716 78851 0 None 3 2 Mouse 6.1 pKi = 6.1 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 467 6 3 3 6.7 O=C(O)c1cccc(NC(=O)c2[nH]c(-c3ccc4ccccc4c3)nc2CC2CCCCCC2)c1 10.1021/jm049069y
CHEMBL2067960 78851 0 None 3 2 Mouse 6.1 pKi = 6.1 Binding
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 467 6 3 3 6.7 O=C(O)c1cccc(NC(=O)c2[nH]c(-c3ccc4ccccc4c3)nc2CC2CCCCCC2)c1 10.1021/jm049069y
11512151 203565 0 None -158 2 Human 5.1 pKi = 5.1 Binding
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 534 7 2 6 5.5 CC(C)(CNC(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.09.064
CHEMBL565511 203565 0 None -158 2 Human 5.1 pKi = 5.1 Binding
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 534 7 2 6 5.5 CC(C)(CNC(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.09.064
45487003 204369 0 None -100 2 Human 5.1 pKi = 5.1 Binding
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 540 7 2 6 5.4 O=C(NCCc1ccc(Cl)c(Cl)c1)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.064
CHEMBL570521 204369 0 None -100 2 Human 5.1 pKi = 5.1 Binding
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 540 7 2 6 5.4 O=C(NCCc1ccc(Cl)c(Cl)c1)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.064
25033382 100932 0 None - 1 Human 5.1 pKi = 5.1 Binding
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 630 6 1 6 6.4 COC(=O)c1sc(C(F)(F)F)c(-c2ccccc2)c1S(=O)(=O)Nc1cc(Br)ccc1C(=O)N1CCCCC1 10.1016/j.bmcl.2007.09.087
CHEMBL249468 100932 0 None - 1 Human 5.1 pKi = 5.1 Binding
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 630 6 1 6 6.4 COC(=O)c1sc(C(F)(F)F)c(-c2ccccc2)c1S(=O)(=O)Nc1cc(Br)ccc1C(=O)N1CCCCC1 10.1016/j.bmcl.2007.09.087
25033384 101294 0 None - 1 Human 5.1 pKi = 5.1 Binding
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 504 5 1 6 4.2 Cc1nnc(-c2cccc(S(=O)(=O)Nc3cc(Br)ccc3C(=O)N3CCCCC3)c2)o1 10.1016/j.bmcl.2007.09.087
CHEMBL251653 101294 0 None - 1 Human 5.1 pKi = 5.1 Binding
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 504 5 1 6 4.2 Cc1nnc(-c2cccc(S(=O)(=O)Nc3cc(Br)ccc3C(=O)N3CCCCC3)c2)o1 10.1016/j.bmcl.2007.09.087
25033383 174195 0 None - 1 Human 5.1 pKi = 5.1 Binding
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 502 5 1 5 4.4 Cc1c(S(=O)(=O)Nc2cc(Br)ccc2C(=O)N2CCCCC2)cnn1-c1ccccc1 10.1016/j.bmcl.2007.09.087
CHEMBL429662 174195 0 None - 1 Human 5.1 pKi = 5.1 Binding
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 502 5 1 5 4.4 Cc1c(S(=O)(=O)Nc2cc(Br)ccc2C(=O)N2CCCCC2)cnn1-c1ccccc1 10.1016/j.bmcl.2007.09.087
11292979 88839 0 None - 1 Human 5.1 pKi = 5.1 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 417 4 2 7 2.7 Nc1ccc(C(=O)N2CCCCC2)c(NS(=O)(=O)c2cccc3nsnc23)c1 10.1021/jm060590x
CHEMBL216559 88839 0 None - 1 Human 5.1 pKi = 5.1 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 417 4 2 7 2.7 Nc1ccc(C(=O)N2CCCCC2)c(NS(=O)(=O)c2cccc3nsnc23)c1 10.1021/jm060590x
16090789 90025 0 None -3 2 Human 5.1 pKi = 5.1 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 521 6 2 7 4.4 O=C(Nc1ccc(C(=O)N2CCCCC2)c(NS(=O)(=O)c2cccc3nsnc23)c1)c1ccccc1 10.1021/jm060590x
CHEMBL218729 90025 0 None -3 2 Human 5.1 pKi = 5.1 Binding
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 521 6 2 7 4.4 O=C(Nc1ccc(C(=O)N2CCCCC2)c(NS(=O)(=O)c2cccc3nsnc23)c1)c1ccccc1 10.1021/jm060590x
11799257 120244 0 None 32 2 Human 8.1 pKi = 8.1 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 490 6 2 3 5.1 O=C(Nc1ccccc1)NC1C(=O)N(CCc2ccccc2)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
CHEMBL331929 120244 0 None 32 2 Human 8.1 pKi = 8.1 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 490 6 2 3 5.1 O=C(Nc1ccccc1)NC1C(=O)N(CCc2ccccc2)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
5311347 39800 3 None - 1 Mouse 8.1 pKi = 8.1 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 557 10 4 4 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccccc1 10.1021/jm00087a011
CHEMBL141630 39800 3 None - 1 Mouse 8.1 pKi = 8.1 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 557 10 4 4 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccccc1 10.1021/jm00087a011
10480793 122203 0 None - 1 Mouse 8.1 pKi = 8.1 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 491 9 4 4 4.5 C[C@@H]1CCCC[C@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00087a011
CHEMBL3350395 122203 0 None - 1 Mouse 8.1 pKi = 8.1 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 491 9 4 4 4.5 C[C@@H]1CCCC[C@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00087a011
11540402 145581 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 488 6 1 4 5.8 Cc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
CHEMBL378098 145581 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 488 6 1 4 5.8 Cc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
10439779 113463 0 None -1 3 Rat 7.1 pKi = 7.1 Binding
Affinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cellsAffinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cells
ChEMBL 710 11 7 8 2.2 C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCSSCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm9603072
CHEMBL3143501 113463 0 None -1 3 Rat 7.1 pKi = 7.1 Binding
Affinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cellsAffinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cells
ChEMBL 710 11 7 8 2.2 C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCSSCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm9603072
118719287 122262 0 None 6 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL 727 17 4 7 4.8 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1cccc2ccccc12)N(C)C)C(=O)N(C)[C@@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C 10.1021/jm00053a022
CHEMBL3351059 122262 0 None 6 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL 727 17 4 7 4.8 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1cccc2ccccc12)N(C)C)C(=O)N(C)[C@@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C 10.1021/jm00053a022
118719251 122247 0 None - 1 Mouse 7.1 pKi = 7.1 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 600 11 5 5 4.6 CC1(C)C2CCC1(C)[C@@H](OC(=O)N[C@H](Cc1c[nH]c3ccccc13)C(=O)NC[C@H](NC(=O)/C=C/C(=O)O)c1ccccc1)C2 10.1021/jm00087a011
CHEMBL3351015 122247 0 None - 1 Mouse 7.1 pKi = 7.1 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 600 11 5 5 4.6 CC1(C)C2CCC1(C)[C@@H](OC(=O)N[C@H](Cc1c[nH]c3ccccc13)C(=O)NC[C@H](NC(=O)/C=C/C(=O)O)c1ccccc1)C2 10.1021/jm00087a011
44280595 124750 0 None - 1 Rat 6.1 pKi = 6.1 Binding
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 667 8 3 5 6.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1CC[C@H](Oc2ccc(Cl)cc2Cl)C[C@@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
CHEMBL34037 124750 0 None - 1 Rat 6.1 pKi = 6.1 Binding
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 667 8 3 5 6.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1CC[C@H](Oc2ccc(Cl)cc2Cl)C[C@@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
15024387 122201 0 None - 1 Mouse 6.1 pKi = 6.1 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 515 9 4 4 4.4 O=C(N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1)OC1C2CC3CC(C2)CC1C3 10.1021/jm00087a011
CHEMBL3350393 122201 0 None - 1 Mouse 6.1 pKi = 6.1 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 515 9 4 4 4.4 O=C(N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1)OC1C2CC3CC(C2)CC1C3 10.1021/jm00087a011
9869202 78851 0 None 3 2 Mouse 6.1 pKi = 6.1 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 467 6 3 3 6.7 O=C(O)c1cccc(NC(=O)c2[nH]c(-c3ccc4ccccc4c3)nc2CC2CCCCCC2)c1 10.1021/jm0490686
CHEMBL197716 78851 0 None 3 2 Mouse 6.1 pKi = 6.1 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 467 6 3 3 6.7 O=C(O)c1cccc(NC(=O)c2[nH]c(-c3ccc4ccccc4c3)nc2CC2CCCCCC2)c1 10.1021/jm0490686
CHEMBL2067960 78851 0 None 3 2 Mouse 6.1 pKi = 6.1 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 467 6 3 3 6.7 O=C(O)c1cccc(NC(=O)c2[nH]c(-c3ccc4ccccc4c3)nc2CC2CCCCCC2)c1 10.1021/jm0490686
11679213 140321 0 None -8 3 Mouse 7.1 pKi = 7.1 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 497 7 3 3 6.8 Cc1ccc(-c2nc(C(=O)Nc3cccc(C(=O)O)c3)c(CCC34CC5CC(CC(C5)C3)C4)[nH]2)c(C)c1 10.1021/jm0490686
CHEMBL370882 140321 0 None -8 3 Mouse 7.1 pKi = 7.1 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 497 7 3 3 6.8 Cc1ccc(-c2nc(C(=O)Nc3cccc(C(=O)O)c3)c(CCC34CC5CC(CC(C5)C3)C4)[nH]2)c(C)c1 10.1021/jm0490686
9850043 119650 2 None 1 3 Human 7.1 pKi = 7.1 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 534 5 2 3 6.1 O=C(Nc1ccccc1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
CHEMBL330977 119650 2 None 1 3 Human 7.1 pKi = 7.1 Binding
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 534 5 2 3 6.1 O=C(Nc1ccccc1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
44356654 34882 0 None -1 2 Mouse 5.1 pKi = 5.1 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 691 9 3 3 7.8 Cc1ccc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc1C 10.1021/jm00021a019
CHEMBL137308 34882 0 None -1 2 Mouse 5.1 pKi = 5.1 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 691 9 3 3 7.8 Cc1ccc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc1C 10.1021/jm00021a019
11685703 78695 0 None -316 3 Mouse 5.1 pKi = 5.1 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 391 7 3 3 4.9 Cc1ccccc1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC(C)C)[nH]1 10.1021/jm0490686
CHEMBL197205 78695 0 None -316 3 Mouse 5.1 pKi = 5.1 Binding
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 391 7 3 3 4.9 Cc1ccccc1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC(C)C)[nH]1 10.1021/jm0490686
44357045 33348 0 None -85 2 Rat 7.1 pKi = 7.1 Binding
Binding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomesBinding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomes
ChEMBL 1012 28 9 13 0.7 CSCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm970477u
CHEMBL136096 33348 0 None -85 2 Rat 7.1 pKi = 7.1 Binding
Binding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomesBinding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomes
ChEMBL 1012 28 9 13 0.7 CSCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm970477u
CHEMBL2369815 216472 0 None -85 2 Rat 7.1 pKi = 7.1 Binding
Binding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligand
ChEMBL None None None CSCC[C@@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCSC)C(=O)N[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm990252e
CHEMBL333477 218171 0 None -19 3 Rat 7.1 pKi = 7.1 Binding
Affinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cellsAffinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cells
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm9603072
10323690 107274 0 None 21 2 Human 7.1 pKi = 7.1 Binding
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 499 8 3 3 5.4 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccc1 10.1021/jm00072a005
CHEMBL2114401 107274 0 None 21 2 Human 7.1 pKi = 7.1 Binding
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 499 8 3 3 5.4 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccc1 10.1021/jm00072a005
CHEMBL291033 107274 0 None 21 2 Human 7.1 pKi = 7.1 Binding
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 499 8 3 3 5.4 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccc1 10.1021/jm00072a005
10324322 114482 0 None 43 2 Human 7.1 pKi = 7.1 Binding
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 518 10 2 4 4.7 CC(Cc1ccccc1)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccc1)CC(=O)O 10.1021/jm00072a005
CHEMBL319085 114482 0 None 43 2 Human 7.1 pKi = 7.1 Binding
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 518 10 2 4 4.7 CC(Cc1ccccc1)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccc1)CC(=O)O 10.1021/jm00072a005
44356826 126084 0 None 19 2 Mouse 7.1 pKi = 7.1 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 781 12 5 6 6.6 COc1ccc(C[C@@H](NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)C(=O)Nc2cc(C(=O)O)cc(C(=O)O)c2)cc1 10.1021/jm00021a019
CHEMBL344014 126084 0 None 19 2 Mouse 7.1 pKi = 7.1 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 781 12 5 6 6.6 COc1ccc(C[C@@H](NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)C(=O)Nc2cc(C(=O)O)cc(C(=O)O)c2)cc1 10.1021/jm00021a019
443375 214385 45 None -316 5 Human 7.1 pKi = 7.1 Binding
Inhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of guinea pigInhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of guinea pig
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm990967h
CHEMBL9506 214385 45 None -316 5 Human 7.1 pKi = 7.1 Binding
Inhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of guinea pigInhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of guinea pig
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm990967h
10698746 123563 0 None 3 2 Mouse 6.1 pKi = 6.1 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 595 7 3 4 4.0 O=C(O)CNC(=O)[C@H]1CCCN1C(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC12C[C@H]3C[C@@H](C1)C[C@@H](C2)C3 10.1021/jm00021a019
CHEMBL337743 123563 0 None 3 2 Mouse 6.1 pKi = 6.1 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 595 7 3 4 4.0 O=C(O)CNC(=O)[C@H]1CCCN1C(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC12C[C@H]3C[C@@H](C1)C[C@@H](C2)C3 10.1021/jm00021a019
10794691 123840 0 None -1 2 Mouse 6.1 pKi = 6.1 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 684 10 5 4 5.3 O=C(O)CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC12CC3CC(CC(C3)C1)C2 10.1021/jm00021a019
CHEMBL339177 123840 0 None -1 2 Mouse 6.1 pKi = 6.1 Binding
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 684 10 5 4 5.3 O=C(O)CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC12CC3CC(CC(C3)C1)C2 10.1021/jm00021a019
9985004 214397 0 None 26 2 Human 7.1 pKi = 7.1 Binding
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 549 8 3 3 6.5 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1cccc2ccccc12 10.1021/jm00072a005
CHEMBL95115 214397 0 None 26 2 Human 7.1 pKi = 7.1 Binding
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 549 8 3 3 6.5 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1cccc2ccccc12 10.1021/jm00072a005
44425005 149232 0 None 79 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 478 7 2 5 4.2 CC(C)C1=NN(CC(=O)Nc2cccc(C(=O)O)c2)C(=O)N(CC(=O)C(C)(C)C)c2ccccc21 10.1021/jm070139l
CHEMBL389019 149232 0 None 79 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 478 7 2 5 4.2 CC(C)C1=NN(CC(=O)Nc2cccc(C(=O)O)c2)C(=O)N(CC(=O)C(C)(C)C)c2ccccc21 10.1021/jm070139l
10651206 121867 0 None - 1 Mouse 6.1 pKi = 6.1 Binding
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 599 8 2 5 4.6 CC(=O)N1[C@H](C(=O)NCCC(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
CHEMBL334320 121867 0 None - 1 Mouse 6.1 pKi = 6.1 Binding
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 599 8 2 5 4.6 CC(=O)N1[C@H](C(=O)NCCC(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
44296980 108799 0 None 9 2 Mouse 6.1 pKi = 6.1 Binding
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 538 5 2 3 4.9 O=C(NCC12CC3CC(CC(C3)C1)C2)C1C2c3ccccc3C(c3ccccc32)C1C(=O)N1CCC[C@@H]1C(=O)O 10.1021/jm9508907
CHEMBL301740 108799 0 None 9 2 Mouse 6.1 pKi = 6.1 Binding
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 538 5 2 3 4.9 O=C(NCC12CC3CC(CC(C3)C1)C2)C1C2c3ccccc3C(c3ccccc32)C1C(=O)N1CCC[C@@H]1C(=O)O 10.1021/jm9508907
44346952 120890 0 None 9 2 Mouse 6.1 pKi = 6.1 Binding
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 538 5 2 3 4.8 O=C(NCC1C2CC3CC(C2)CC1C3)C1C2c3ccccc3C(c3ccccc32)C1C(=O)N1CCC[C@@H]1C(=O)O 10.1021/jm00048a001
CHEMBL332782 120890 0 None 9 2 Mouse 6.1 pKi = 6.1 Binding
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 538 5 2 3 4.8 O=C(NCC1C2CC3CC(C2)CC1C3)C1C2c3ccccc3C(c3ccccc32)C1C(=O)N1CCC[C@@H]1C(=O)O 10.1021/jm00048a001
15297881 120282 0 None - 1 Mouse 5.1 pKi = 5.1 Binding
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 411 6 2 2 4.3 O=C(O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCCCc1ccccc1 10.1021/jm00048a001
CHEMBL332061 120282 0 None - 1 Mouse 5.1 pKi = 5.1 Binding
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 411 6 2 2 4.3 O=C(O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCCCc1ccccc1 10.1021/jm00048a001
44280156 175099 0 None - 1 Rat 6.1 pKi = 6.1 Binding
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 667 8 3 5 6.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1CC[C@@H](Oc2ccc(Cl)cc2Cl)C[C@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
CHEMBL434199 175099 0 None - 1 Rat 6.1 pKi = 6.1 Binding
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 667 8 3 5 6.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1CC[C@@H](Oc2ccc(Cl)cc2Cl)C[C@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
44272041 103858 0 None 338 2 Human 8.0 pKi = 8.0 Binding
Displacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranesDisplacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranes
ChEMBL 1274 26 13 15 2.1 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc2ccc(OS(=O)(=O)O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00126a007
CHEMBL267329 103858 0 None 338 2 Human 8.0 pKi = 8.0 Binding
Displacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranesDisplacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranes
ChEMBL 1274 26 13 15 2.1 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc2ccc(OS(=O)(=O)O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00126a007
11642370 146949 0 None 95 2 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 540 7 1 6 5.7 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-n3ccnc3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
CHEMBL380363 146949 0 None 95 2 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 540 7 1 6 5.7 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-n3ccnc3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
16732592 150360 1 None 870 2 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 572 8 2 7 4.9 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2ccc3c(cnn3CC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL389933 150360 1 None 870 2 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 572 8 2 7 4.9 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2ccc3c(cnn3CC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL64605 222635 7 None 4 3 Rat 8.0 pKi = 8.0 Binding
Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm0000416
44451877 102756 0 None 2 3 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 587 7 1 6 6.9 Cc1nc(-c2cccc(NC(=O)CN3C(=O)N(CC(=O)C(C)(C)C)c4ccccc4N(C4CCCCC4)C3=O)c2)cs1 10.1016/j.bmc.2007.12.047
CHEMBL259557 102756 0 None 2 3 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 587 7 1 6 6.9 Cc1nc(-c2cccc(NC(=O)CN3C(=O)N(CC(=O)C(C)(C)C)c4ccccc4N(C4CCCCC4)C3=O)c2)cs1 10.1016/j.bmc.2007.12.047
44451920 102901 0 None 2 3 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 519 7 2 5 5.5 CNc1cccc(NC(=O)CN2C(=O)N(CC(=O)C(C)(C)C)c3ccccc3N(C3CCCCC3)C2=O)c1 10.1016/j.bmc.2007.12.047
CHEMBL260394 102901 0 None 2 3 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 519 7 2 5 5.5 CNc1cccc(NC(=O)CN2C(=O)N(CC(=O)C(C)(C)C)c3ccccc3N(C3CCCCC3)C2=O)c1 10.1016/j.bmc.2007.12.047
10698558 123999 0 None -3 2 Human 7.0 pKi = 7.0 Binding
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 585 8 3 5 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccccc2)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL339451 123999 0 None -3 2 Human 7.0 pKi = 7.0 Binding
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 585 8 3 5 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccccc2)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL120632 215384 33 None -5 3 Rat 7.0 pKi = 7.0 Binding
Affinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cellsAffinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm9603072
CHEMBL3350665 218261 0 None 3 2 Human 7.0 pKi = 7.0 Binding
Apparent affinity to inhibit binding of [3H]pCCK-8 to Cholecystokinin type B receptor of guinea pig brain membranesApparent affinity to inhibit binding of [3H]pCCK-8 to Cholecystokinin type B receptor of guinea pig brain membranes
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00174a016
CHEMBL120632 215384 33 None -5 3 Rat 7.0 pKi = 7.0 Binding
Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.
ChEMBL None None None CSCC[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm0000416
118718880 122202 0 None - 1 Mouse 7.0 pKi = 7.0 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 543 10 4 4 4.8 O=C(O)C[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1021/jm00087a011
CHEMBL3350394 122202 0 None - 1 Mouse 7.0 pKi = 7.0 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 543 10 4 4 4.8 O=C(O)C[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1021/jm00087a011
CHEMBL1172246 215360 0 None -1 4 Human 6.0 pKi = 6.0 Binding
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cells
ChEMBL None None None N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CC(=O)NCCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc2ccccc2)C(N)=O)NC(=O)[C@H](Cc2cc3ccccc3[nH]2)NC1=O 10.1016/j.bmcl.2010.05.078
44408483 175708 0 None -275 4 Human 6.0 pKi = 6.0 Binding
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1212 31 12 15 3.7 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@H](Cc1cn(C(=O)OC2C3CC4CC(C3)CC2C4)c2ccccc12)C(=O)O 10.1021/jm050851n
CHEMBL438739 175708 0 None -275 4 Human 6.0 pKi = 6.0 Binding
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1212 31 12 15 3.7 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@H](Cc1cn(C(=O)OC2C3CC4CC(C3)CC2C4)c2ccccc12)C(=O)O 10.1021/jm050851n
44408484 144286 0 None -18197 4 Human 5.0 pKi = 5.0 Binding
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1033 30 13 12 1.4 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm050851n
CHEMBL375412 144286 0 None -18197 4 Human 5.0 pKi = 5.0 Binding
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1033 30 13 12 1.4 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm050851n
44418924 163661 0 None -18620 4 Human 5.0 pKi = 5.0 Binding
Displacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1031 27 13 12 0.2 CCCC[C@H](NC(=O)[C@H](N)Cc1cc2ccccc2[nH]1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061268p
CHEMBL407198 163661 0 None -18620 4 Human 5.0 pKi = 5.0 Binding
Displacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1031 27 13 12 0.2 CCCC[C@H](NC(=O)[C@H](N)Cc1cc2ccccc2[nH]1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061268p
10839906 117205 0 None - 1 Mouse 6.0 pKi = 6.0 Binding
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 528 5 1 4 5.1 CC(=O)N1[C@H](C(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
CHEMBL324557 117205 0 None - 1 Mouse 6.0 pKi = 6.0 Binding
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 528 5 1 4 5.1 CC(=O)N1[C@H](C(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
10676691 22335 0 None - 1 Human 7.0 pKi = 7.0 Binding
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 663 19 7 7 0.7 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCN 10.1021/jm0000416
CHEMBL122012 22335 0 None - 1 Human 7.0 pKi = 7.0 Binding
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 663 19 7 7 0.7 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCN 10.1021/jm0000416
19043358 11133 0 None -22 2 Human 6.0 pKi = 6.0 Binding
Binding affinity was measured by its ability to displace [3H]CCK-8S from CCK-B receptor in guinea pig brainBinding affinity was measured by its ability to displace [3H]CCK-8S from CCK-B receptor in guinea pig brain
ChEMBL 490 6 2 3 5.6 CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccc(Cl)cc21 10.1016/0960-894X(95)00528-2
CHEMBL101125 11133 0 None -22 2 Human 6.0 pKi = 6.0 Binding
Binding affinity was measured by its ability to displace [3H]CCK-8S from CCK-B receptor in guinea pig brainBinding affinity was measured by its ability to displace [3H]CCK-8S from CCK-B receptor in guinea pig brain
ChEMBL 490 6 2 3 5.6 CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccc(Cl)cc21 10.1016/0960-894X(95)00528-2
19043395 11545 0 None -194 2 Human 6.0 pKi = 6.0 Binding
Binding affinity was measured by its ability to displace [3H]CCK-8S from CCK-B receptor in guinea pig brainBinding affinity was measured by its ability to displace [3H]CCK-8S from CCK-B receptor in guinea pig brain
ChEMBL 490 6 2 3 5.6 CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2cc(Cl)ccc21 10.1016/0960-894X(95)00528-2
CHEMBL103968 11545 0 None -194 2 Human 6.0 pKi = 6.0 Binding
Binding affinity was measured by its ability to displace [3H]CCK-8S from CCK-B receptor in guinea pig brainBinding affinity was measured by its ability to displace [3H]CCK-8S from CCK-B receptor in guinea pig brain
ChEMBL 490 6 2 3 5.6 CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2cc(Cl)ccc21 10.1016/0960-894X(95)00528-2
CHEMBL384035 219095 4 None -512 4 Rat 7.0 pKi = 7.0 Binding
Ability to displace 1 nM [3H]pCCK-8 from rat Cholecystokinin type B receptor stably expressing in CHO cellsAbility to displace 1 nM [3H]pCCK-8 from rat Cholecystokinin type B receptor stably expressing in CHO cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2003.11.001
CHEMBL428666 219095 4 None -512 4 Rat 7.0 pKi = 7.0 Binding
Ability to displace 1 nM [3H]pCCK-8 from rat Cholecystokinin type B receptor stably expressing in CHO cellsAbility to displace 1 nM [3H]pCCK-8 from rat Cholecystokinin type B receptor stably expressing in CHO cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2003.11.001
10509945 96159 0 None -229 2 Rat 6.0 pKi = 6.0 Binding
Binding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligand
ChEMBL 896 26 9 9 2.1 CCCC[C@H](NC(=O)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm990252e
CHEMBL2369816 96159 0 None -229 2 Rat 6.0 pKi = 6.0 Binding
Binding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligand
ChEMBL 896 26 9 9 2.1 CCCC[C@H](NC(=O)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm990252e
44345044 117841 0 None - 1 Mouse 7.0 pKi = 7.0 Binding
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 643 7 1 8 5.9 CC(=O)N1[C@H](C(=O)NCC2N=NN=N2)CC(=O)c2ccccc2N(Cc2ccccc2Cl)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
CHEMBL326293 117841 0 None - 1 Mouse 7.0 pKi = 7.0 Binding
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 643 7 1 8 5.9 CC(=O)N1[C@H](C(=O)NCC2N=NN=N2)CC(=O)c2ccccc2N(Cc2ccccc2Cl)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
15513853 120122 0 None - 1 Mouse 7.0 pKi = 7.0 Binding
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 603 7 2 5 4.3 CC(=O)N1[C@H](C(=O)NCC(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2F)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
CHEMBL331719 120122 0 None - 1 Mouse 7.0 pKi = 7.0 Binding
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 603 7 2 5 4.3 CC(=O)N1[C@H](C(=O)NCC(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2F)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
15755202 122195 0 None - 1 Mouse 6.0 pKi = 6.0 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 600 12 5 5 4.5 O=C(O)CCC(=O)N[C@@H](CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3)c1ccccc1 10.1021/jm00087a011
CHEMBL3350356 122195 0 None - 1 Mouse 6.0 pKi = 6.0 Binding
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 600 12 5 5 4.5 O=C(O)CCC(=O)N[C@@H](CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3)c1ccccc1 10.1021/jm00087a011
10793451 103292 0 None - 1 Human 7.0 pKi = 7.0 Binding
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 585 8 3 5 5.2 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@@H](Oc2ccccc2)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL262679 103292 0 None - 1 Human 7.0 pKi = 7.0 Binding
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 585 8 3 5 5.2 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@@H](Oc2ccccc2)C[C@@H]1C(=O)O 10.1021/jm970439a
10253387 214558 0 None - 1 Human 6.0 pKi = 6.0 Binding
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 453 7 4 4 3.2 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCC(=O)O 10.1021/jm00072a005
CHEMBL96036 214558 0 None - 1 Human 6.0 pKi = 6.0 Binding
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 453 7 4 4 3.2 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCC(=O)O 10.1021/jm00072a005
10628765 21024 0 None - 1 Human 6.0 pKi = 6 Binding
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 734 23 7 7 2.4 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCCC(=O)O 10.1021/jm0000416
CHEMBL119960 21024 0 None - 1 Human 6.0 pKi = 6 Binding
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 734 23 7 7 2.4 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCCC(=O)O 10.1021/jm0000416
10531 8202 21 None - 24 Mouse 8.3 pIC50 = 8.3 Binding
Concentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranesConcentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranes
Drug Central 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O None
121 8202 21 None - 24 Mouse 8.3 pIC50 = 8.3 Binding
Concentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranesConcentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranes
Drug Central 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O None
888 8202 21 None - 24 Mouse 8.3 pIC50 = 8.3 Binding
Concentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranesConcentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranes
Drug Central 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O None
CHEMBL1732 8202 21 None - 24 Mouse 8.3 pIC50 = 8.3 Binding
Concentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranesConcentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranes
Drug Central 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O None
DB00320 8202 21 None - 24 Mouse 8.3 pIC50 = 8.3 Binding
Concentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranesConcentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranes
Drug Central 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O None
11954224 222732 0 None - 59 Mouse 8.3 pIC50 = 8.3 Binding
Concentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranesConcentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranes
Drug Central 581 4 3 6 2.0 CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C None
9853654 29561 41 None - 2 Rat 8.1 pIC50 = 8.1 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
Drug Central 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O None
CHEMBL1328 29561 41 None - 2 Rat 8.1 pIC50 = 8.1 Binding
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
Drug Central 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O None
9853654 29561 41 None -31 2 Mouse 8.0 pIC50 = 8.0 Binding
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
Drug Central 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O None
CHEMBL1328 29561 41 None -31 2 Mouse 8.0 pIC50 = 8.0 Binding
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
Drug Central 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O None
4627 7609 50 None - 5 Mouse 8.0 pIC50 = 8.0 Binding
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
Drug Central None None None None None
864 7609 50 None - 5 Mouse 8.0 pIC50 = 8.0 Binding
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
Drug Central None None None None None
9833444 7609 50 None - 5 Mouse 8.0 pIC50 = 8.0 Binding
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
Drug Central None None None None None
CHEMBL1121 7609 50 None - 5 Mouse 8.0 pIC50 = 8.0 Binding
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
Drug Central None None None None None
DB09142 7609 50 None - 5 Mouse 8.0 pIC50 = 8.0 Binding
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
Drug Central None None None None None
104929 9000 9 None 51 3 Human 8.4 pKd = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 11738246
3477 9000 9 None 51 3 Human 8.4 pKd = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 11738246
879 9000 9 None 51 3 Human 8.4 pKd = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 11738246
CHEMBL289498 9000 9 None 51 3 Human 8.4 pKd = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 11738246
4627 7609 50 125I-CCK-8 1 5 Rat 10.0 pKi = 10 Binding
NoneNone
PDSP KiDatabase None None None None None
864 7609 50 125I-CCK-8 1 5 Rat 10.0 pKi = 10 Binding
NoneNone
PDSP KiDatabase None None None None None
9833444 7609 50 125I-CCK-8 1 5 Rat 10.0 pKi = 10 Binding
NoneNone
PDSP KiDatabase None None None None None
CHEMBL1121 7609 50 125I-CCK-8 1 5 Rat 10.0 pKi = 10 Binding
NoneNone
PDSP KiDatabase None None None None None
DB09142 7609 50 125I-CCK-8 1 5 Rat 10.0 pKi = 10 Binding
NoneNone
PDSP KiDatabase None None None None None
443375 214385 45 125I-BH-CCK-8 2 5 Mouse 10.0 pKi = 10 Binding
NoneNone
PDSP KiDatabase 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 None
CHEMBL9506 214385 45 125I-BH-CCK-8 2 5 Mouse 10.0 pKi = 10 Binding
NoneNone
PDSP KiDatabase 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 None
146158392 223027 0 125I-BH-CCK-8 - 1 Mouse 10.0 pKi = 10 Binding
NoneNone
PDSP KiDatabase 1079 31 14 15 -0.6 CSCCC(C(=O)NCC(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CCSC)C(=O)NC(CC(=O)O)C(=O)NC(CC3=CC=CC=C3)C(=O)N)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CC(=O)O)N.N None
443375 214385 45 3H-pCCK8 -389 5 Rat 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 None
CHEMBL9506 214385 45 3H-pCCK8 -389 5 Rat 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 None
3476 8182 9 125I-CCK -2 3 Rat 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase 408 3 2 3 3.7 O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 None
59751 8182 9 125I-CCK -2 3 Rat 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase 408 3 2 3 3.7 O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 None
878 8182 9 125I-CCK -2 3 Rat 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase 408 3 2 3 3.7 O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 None
CHEMBL39263 8182 9 125I-CCK -2 3 Rat 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase 408 3 2 3 3.7 O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 None
4627 7609 50 125I-CCK-8 1 5 Rat 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase None None None None None
864 7609 50 125I-CCK-8 1 5 Rat 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase None None None None None
9833444 7609 50 125I-CCK-8 1 5 Rat 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase None None None None None
CHEMBL1121 7609 50 125I-CCK-8 1 5 Rat 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase None None None None None
DB09142 7609 50 125I-CCK-8 1 5 Rat 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase None None None None None
None 223025 0 125I-CCK-8 - 1 Rat 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 438 3 2 3 3.8 C1CN2C(=O)C(N=C(C3=C2C1=CC=C3)C4=CC=CC=C4F)NC(=O)C5=CC6=CC=CC=C6N5 None
3476 8182 9 125I-CCK-8 -2 3 Rat 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 408 3 2 3 3.7 O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 None
59751 8182 9 125I-CCK-8 -2 3 Rat 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 408 3 2 3 3.7 O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 None
878 8182 9 125I-CCK-8 -2 3 Rat 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 408 3 2 3 3.7 O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 None
CHEMBL39263 8182 9 125I-CCK-8 -2 3 Rat 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 408 3 2 3 3.7 O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 None
4627 7609 50 125I-CCK-8 1 5 Rat 9.3 pKi = 9.3 Binding
NoneNone
PDSP KiDatabase None None None None None
864 7609 50 125I-CCK-8 1 5 Rat 9.3 pKi = 9.3 Binding
NoneNone
PDSP KiDatabase None None None None None
9833444 7609 50 125I-CCK-8 1 5 Rat 9.3 pKi = 9.3 Binding
NoneNone
PDSP KiDatabase None None None None None
CHEMBL1121 7609 50 125I-CCK-8 1 5 Rat 9.3 pKi = 9.3 Binding
NoneNone
PDSP KiDatabase None None None None None
DB09142 7609 50 125I-CCK-8 1 5 Rat 9.3 pKi = 9.3 Binding
NoneNone
PDSP KiDatabase None None None None None
4627 7609 50 3H-pCCK8 1 5 Rat 9.3 pKi = 9.3 Binding
NoneNone
PDSP KiDatabase None None None None None
864 7609 50 3H-pCCK8 1 5 Rat 9.3 pKi = 9.3 Binding
NoneNone
PDSP KiDatabase None None None None None
9833444 7609 50 3H-pCCK8 1 5 Rat 9.3 pKi = 9.3 Binding
NoneNone
PDSP KiDatabase None None None None None
CHEMBL1121 7609 50 3H-pCCK8 1 5 Rat 9.3 pKi = 9.3 Binding
NoneNone
PDSP KiDatabase None None None None None
DB09142 7609 50 3H-pCCK8 1 5 Rat 9.3 pKi = 9.3 Binding
NoneNone
PDSP KiDatabase None None None None None
122077 9102 51 125I-CCK - 1 Rat 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 411 5 2 5 4.8 OC(=O)Cn1c(cc2c1cccc2)C(=O)Nc1scc(n1)c1ccccc1Cl None
890 9102 51 125I-CCK - 1 Rat 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 411 5 2 5 4.8 OC(=O)Cn1c(cc2c1cccc2)C(=O)Nc1scc(n1)c1ccccc1Cl None
CHEMBL249973 9102 51 125I-CCK - 1 Rat 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 411 5 2 5 4.8 OC(=O)Cn1c(cc2c1cccc2)C(=O)Nc1scc(n1)c1ccccc1Cl None
DB04867 9102 51 125I-CCK - 1 Rat 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 411 5 2 5 4.8 OC(=O)Cn1c(cc2c1cccc2)C(=O)Nc1scc(n1)c1ccccc1Cl None
4627 7609 50 125I-BH-CCK-8 -1 5 Human 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase None None None None None
864 7609 50 125I-BH-CCK-8 -1 5 Human 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase None None None None None
9833444 7609 50 125I-BH-CCK-8 -1 5 Human 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase None None None None None
CHEMBL1121 7609 50 125I-BH-CCK-8 -1 5 Human 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase None None None None None
DB09142 7609 50 125I-BH-CCK-8 -1 5 Human 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase None None None None None
16129670 7603 0 125I-CCK -3 2 Rat 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase None None None None None
860 7603 0 125I-CCK -3 2 Rat 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase None None None None None
91898395 7603 0 125I-CCK -3 2 Rat 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase None None None None None
135398737 7745 93 3H-CCK8 -416 90 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
38 7745 93 3H-CCK8 -416 90 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
722 7745 93 3H-CCK8 -416 90 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
CHEMBL42 7745 93 3H-CCK8 -416 90 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
DB00363 7745 93 3H-CCK8 -416 90 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
202 8290 77 UNDEFINED -9 33 Mouse 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
60835 8290 77 UNDEFINED -9 33 Mouse 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
972 8290 77 UNDEFINED -9 33 Mouse 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
CHEMBL1175 8290 77 UNDEFINED -9 33 Mouse 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
DB00476 8290 77 UNDEFINED -9 33 Mouse 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
1222 8445 49 3H-CCK8 -1659 32 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
3396 8445 49 3H-CCK8 -1659 32 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
85 8445 49 3H-CCK8 -1659 32 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
CHEMBL46516 8445 49 3H-CCK8 -1659 32 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
DB04842 8445 49 3H-CCK8 -1659 32 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
1353 8692 93 3H-CCK8 -691 85 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
3559 8692 93 3H-CCK8 -691 85 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
86 8692 93 3H-CCK8 -691 85 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
CHEMBL54 8692 93 3H-CCK8 -691 85 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
DB00502 8692 93 3H-CCK8 -691 85 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
135398745 9688 112 3H-CCK8 -512 65 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
47 9688 112 3H-CCK8 -512 65 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
CHEMBL715 9688 112 3H-CCK8 -512 65 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
DB00334 9688 112 3H-CCK8 -512 65 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
2181 9902 46 3H-CCK8 -831 34 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 375 7 1 4 2.6 O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N None
4830 9902 46 3H-CCK8 -831 34 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 375 7 1 4 2.6 O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N None
92 9902 46 3H-CCK8 -831 34 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 375 7 1 4 2.6 O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N None
CHEMBL440294 9902 46 3H-CCK8 -831 34 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 375 7 1 4 2.6 O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N None
DB09286 9902 46 3H-CCK8 -831 34 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 375 7 1 4 2.6 O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N None
2337 10030 77 3H-CCK8 -112 62 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
50 10030 77 3H-CCK8 -112 62 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
5002 10030 77 3H-CCK8 -112 62 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
CHEMBL716 10030 77 3H-CCK8 -112 62 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
DB01224 10030 77 3H-CCK8 -112 62 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
2389 10104 118 3H-CCK8 -2691 66 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
5073 10104 118 3H-CCK8 -2691 66 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
96 10104 118 3H-CCK8 -2691 66 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
CHEMBL85 10104 118 3H-CCK8 -2691 66 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
DB00734 10104 118 3H-CCK8 -2691 66 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
2435 10362 83 3H-CCK8 -1949 48 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
60149 10362 83 3H-CCK8 -1949 48 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
98 10362 83 3H-CCK8 -1949 48 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
CHEMBL12713 10362 83 3H-CCK8 -1949 48 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
DB06144 10362 83 3H-CCK8 -1949 48 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
2865 10915 73 3H-CCK8 -2041 53 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
59 10915 73 3H-CCK8 -2041 53 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
60854 10915 73 3H-CCK8 -2041 53 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
CHEMBL708 10915 73 3H-CCK8 -2041 53 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
DB00246 10915 73 3H-CCK8 -2041 53 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
103 10925 61 3H-CCK8 -831 53 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
2875 10925 61 3H-CCK8 -831 53 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
5736 10925 61 3H-CCK8 -831 53 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
CHEMBL285802 10925 61 3H-CCK8 -831 53 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
DB09225 10925 61 3H-CCK8 -831 53 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
115237 62359 119 3H-CCK8 -4265 54 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 426 4 1 7 3.1 Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O None
CHEMBL1621 62359 119 3H-CCK8 -4265 54 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 426 4 1 7 3.1 Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O None
46780481 114308 20 3H-CCK8 -5888 53 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
9903970 114308 20 3H-CCK8 -5888 53 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
CHEMBL3187365 114308 20 3H-CCK8 -5888 53 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
CHEMBL3544974 114308 20 3H-CCK8 -5888 53 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
5656 209845 87 UNDEFINED -7 43 Mouse 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 277 5 1 3 3.0 COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1 None
CHEMBL637 209845 87 UNDEFINED -7 43 Mouse 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 277 5 1 3 3.0 COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1 None
54841 209906 52 UNDEFINED -1 30 Mouse 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 255 6 1 2 3.7 CNCC[C@@H](Oc1ccccc1C)c1ccccc1 None
CHEMBL641 209906 52 UNDEFINED -1 30 Mouse 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 255 6 1 2 3.7 CNCC[C@@H](Oc1ccccc1C)c1ccccc1 None
3075702 224111 0 3H-Devazepide -2 37 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 198 3 1 3 1.5 C1CNC1COC2=CN=C(C=C2)Cl None
1192 6935 47 3H-CCK8 -162 17 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 311 2 3 5 0.5 NC(=NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1)N None
1794 6935 47 3H-CCK8 -162 17 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 311 2 3 5 0.5 NC(=NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1)N None
CHEMBL501701 6935 47 3H-CCK8 -162 17 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 311 2 3 5 0.5 NC(=NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1)N None
119376 8622 48 3H-L364718 -54954 27 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 393 7 1 6 1.6 O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C None
247 8622 48 3H-L364718 -54954 27 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 393 7 1 6 1.6 O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C None
CHEMBL33884 8622 48 3H-L364718 -54954 27 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 393 7 1 6 1.6 O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C None
3294 8787 111 3H-L354718 -323 44 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
71360 8787 111 3H-L354718 -323 44 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
87 8787 111 3H-L354718 -323 44 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
CHEMBL14376 8787 111 3H-L354718 -323 44 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
DB04946 8787 111 3H-L354718 -323 44 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
1614 9128 67 125I-CCK-8 - 1 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 460 14 2 4 4.0 CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCOC None
60182 9128 67 125I-CCK-8 - 1 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 460 14 2 4 4.0 CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCOC None
892 9128 67 125I-CCK-8 - 1 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 460 14 2 4 4.0 CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCOC None
CHEMBL206025 9128 67 125I-CCK-8 - 1 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 460 14 2 4 4.0 CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCOC None
243 9976 91 3H-CCK8 -1096 34 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
3052762 9976 91 3H-CCK8 -1096 34 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
3502 9976 91 3H-CCK8 -1096 34 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
CHEMBL117287 9976 91 3H-CCK8 -1096 34 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
DB06480 9976 91 3H-CCK8 -1096 34 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
108107 86719 38 3H-CCK8 -15 16 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 319 3 4 5 0.5 N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCc1ccccc1 None
156592250 86719 38 3H-CCK8 -15 16 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 319 3 4 5 0.5 N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCc1ccccc1 None
CHEMBL1256878 86719 38 3H-CCK8 -15 16 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 319 3 4 5 0.5 N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCc1ccccc1 None
CHEMBL212579 86719 38 3H-CCK8 -15 16 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 319 3 4 5 0.5 N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCc1ccccc1 None
3025067 106158 64 3H-CCK8 -512 15 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 220 1 1 4 0.9 c1cc2c(c(N3CCNCC3)c1)OCCO2 None
65853 106158 64 3H-CCK8 -512 15 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 220 1 1 4 0.9 c1cc2c(c(N3CCNCC3)c1)OCCO2 None
CHEMBL282614 106158 64 3H-CCK8 -512 15 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 220 1 1 4 0.9 c1cc2c(c(N3CCNCC3)c1)OCCO2 None
44208932 147485 7 UNDEFINED -89125 37 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 475 5 1 3 6.8 Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1 None
CHEMBL381689 147485 7 UNDEFINED -89125 37 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 475 5 1 3 6.8 Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1 None
4595 183494 106 3H-CCK8 -6 14 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 293 2 0 4 3.1 Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O None
CHEMBL46 183494 106 3H-CCK8 -6 14 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 293 2 0 4 3.1 Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O None
1973 210262 15 3H-Devazepide -3 36 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 462 3 1 7 3.9 Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 None
CHEMBL1394464 210262 15 3H-Devazepide -3 36 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 462 3 1 7 3.9 Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 None
CHEMBL66089 210262 15 3H-Devazepide -3 36 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 462 3 1 7 3.9 Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 None
16231 214288 57 3H-CCK8 -7 17 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 229 1 5 6 -1.1 N=C(N)NC(=O)c1nc(Cl)c(N)nc1N None
CHEMBL945 214288 57 3H-CCK8 -7 17 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 229 1 5 6 -1.1 N=C(N)NC(=O)c1nc(Cl)c(N)nc1N None
None 223272 0 3H-CCK8 -10471285 17 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 372 2 1 3 4.4 CC(C)(C)C1=CC=C(C=C1)NC(=O)N2CCN(CC2)C3=C(C=CC=N3)Cl None
10478703 126690 1 125I-BH-CCK-85 - 1 Rat 5.8 pKi = 5.8 Binding
NoneNone
PDSP KiDatabase 445 2 2 4 4.0 Cc1cccc(NC(=O)NC2N=C(N3CC4CCC(CC4)C3)c3ccccc3N(C)C2=O)c1 None
CHEMBL349291 126690 1 125I-BH-CCK-85 - 1 Rat 5.8 pKi = 5.8 Binding
NoneNone
PDSP KiDatabase 445 2 2 4 4.0 Cc1cccc(NC(=O)NC2N=C(N3CC4CCC(CC4)C3)c3ccccc3N(C)C2=O)c1 None
104929 9000 9 125I-BH-CCK-8 -51 3 Mouse 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 None
3477 9000 9 125I-BH-CCK-8 -51 3 Mouse 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 None
879 9000 9 125I-BH-CCK-8 -51 3 Mouse 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 None
CHEMBL289498 9000 9 125I-BH-CCK-8 -51 3 Mouse 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 None
1614 9128 67 125I-CCK-8 - 1 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 460 14 2 4 4.0 CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCOC None
60182 9128 67 125I-CCK-8 - 1 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 460 14 2 4 4.0 CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCOC None
892 9128 67 125I-CCK-8 - 1 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 460 14 2 4 4.0 CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCOC None
CHEMBL206025 9128 67 125I-CCK-8 - 1 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 460 14 2 4 4.0 CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCOC None
3476 8182 9 125I-CCK-8 -2 3 Rat 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 408 3 2 3 3.7 O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 None
59751 8182 9 125I-CCK-8 -2 3 Rat 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 408 3 2 3 3.7 O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 None
878 8182 9 125I-CCK-8 -2 3 Rat 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 408 3 2 3 3.7 O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 None
CHEMBL39263 8182 9 125I-CCK-8 -2 3 Rat 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 408 3 2 3 3.7 O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 None
1614 9128 67 125I-CCK-8 - 1 Rat 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 460 14 2 4 4.0 CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCOC None
60182 9128 67 125I-CCK-8 - 1 Rat 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 460 14 2 4 4.0 CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCOC None
892 9128 67 125I-CCK-8 - 1 Rat 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 460 14 2 4 4.0 CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCOC None
CHEMBL206025 9128 67 125I-CCK-8 - 1 Rat 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 460 14 2 4 4.0 CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCOC None
None 223026 0 UNDEFINED - 1 Rat 5.4 pKi = 5.4 Binding
NoneNone
PDSP KiDatabase 809 18 11 11 1.5 CC(CC1=CNC2=CC=CC=C21)(C(=O)NCC(C3=CC=CC=C3)NC(=O)CCC(=O)O)NC(=O)OC4C5CC6CC(C5)CC4C6.CNCC(C(C(C(CO)O)O)O)O None
4595 183494 106 None -6 14 Rat 8.2 pKi = 8.2 Binding
The binding affinity was measured on cholecystokinin type B receptor using [3H]- CCK-8 as radioligand.The binding affinity was measured on cholecystokinin type B receptor using [3H]- CCK-8 as radioligand.
Drug Central 293 2 0 4 3.1 Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O None
CHEMBL46 183494 106 None -6 14 Rat 8.2 pKi = 8.2 Binding
The binding affinity was measured on cholecystokinin type B receptor using [3H]- CCK-8 as radioligand.The binding affinity was measured on cholecystokinin type B receptor using [3H]- CCK-8 as radioligand.
Drug Central 293 2 0 4 3.1 Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O None
9853654 29561 41 125I-BH-CCK-8 -31 2 Mouse 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O None
CHEMBL1328 29561 41 125I-BH-CCK-8 -31 2 Mouse 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O None
9853654 29561 41 None 31 2 Human 8.1 pKi = 8.1 Binding
Inhibition of binding of [125I]-PD 142308 to CCK-B receptor was determinedInhibition of binding of [125I]-PD 142308 to CCK-B receptor was determined
Drug Central 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O None
CHEMBL1328 29561 41 None 31 2 Human 8.1 pKi = 8.1 Binding
Inhibition of binding of [125I]-PD 142308 to CCK-B receptor was determinedInhibition of binding of [125I]-PD 142308 to CCK-B receptor was determined
Drug Central 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O None
104929 9000 9 125I-BH-CCK-85 -165 3 Rat 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 None
3477 9000 9 125I-BH-CCK-85 -165 3 Rat 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 None
879 9000 9 125I-BH-CCK-85 -165 3 Rat 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 None
CHEMBL289498 9000 9 125I-BH-CCK-85 -165 3 Rat 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 None
4627 7609 50 None 1 5 Rat 8.0 pKi = 8.0 Binding
Binding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomesBinding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomes
Drug Central None None None None None
864 7609 50 None 1 5 Rat 8.0 pKi = 8.0 Binding
Binding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomesBinding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomes
Drug Central None None None None None
9833444 7609 50 None 1 5 Rat 8.0 pKi = 8.0 Binding
Binding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomesBinding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomes
Drug Central None None None None None
CHEMBL1121 7609 50 None 1 5 Rat 8.0 pKi = 8.0 Binding
Binding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomesBinding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomes
Drug Central None None None None None
DB09142 7609 50 None 1 5 Rat 8.0 pKi = 8.0 Binding
Binding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomesBinding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomes
Drug Central None None None None None
4627 7609 50 None -1 5 Human 8.0 pKi = 8.0 Binding
Tested for the inhibition of [3H]pCCK-8 binding to Cholecystokinin type B receptor in guinea pig brainTested for the inhibition of [3H]pCCK-8 binding to Cholecystokinin type B receptor in guinea pig brain
Drug Central None None None None None
864 7609 50 None -1 5 Human 8.0 pKi = 8.0 Binding
Tested for the inhibition of [3H]pCCK-8 binding to Cholecystokinin type B receptor in guinea pig brainTested for the inhibition of [3H]pCCK-8 binding to Cholecystokinin type B receptor in guinea pig brain
Drug Central None None None None None
9833444 7609 50 None -1 5 Human 8.0 pKi = 8.0 Binding
Tested for the inhibition of [3H]pCCK-8 binding to Cholecystokinin type B receptor in guinea pig brainTested for the inhibition of [3H]pCCK-8 binding to Cholecystokinin type B receptor in guinea pig brain
Drug Central None None None None None
CHEMBL1121 7609 50 None -1 5 Human 8.0 pKi = 8.0 Binding
Tested for the inhibition of [3H]pCCK-8 binding to Cholecystokinin type B receptor in guinea pig brainTested for the inhibition of [3H]pCCK-8 binding to Cholecystokinin type B receptor in guinea pig brain
Drug Central None None None None None
DB09142 7609 50 None -1 5 Human 8.0 pKi = 8.0 Binding
Tested for the inhibition of [3H]pCCK-8 binding to Cholecystokinin type B receptor in guinea pig brainTested for the inhibition of [3H]pCCK-8 binding to Cholecystokinin type B receptor in guinea pig brain
Drug Central None None None None None
5311400 10066 1 None -2 3 Rat 9.1 pKi = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 14698161
900 10066 1 None -2 3 Rat 9.1 pKi = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 14698161
CHEMBL262197 10066 1 None -2 3 Rat 9.1 pKi = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 14698161
3294 8787 111 None -323 44 Human 8.3 pKi None 8.3 Binding
NoneNone
Drug Central 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
71360 8787 111 None -323 44 Human 8.3 pKi None 8.3 Binding
NoneNone
Drug Central 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
87 8787 111 None -323 44 Human 8.3 pKi None 8.3 Binding
NoneNone
Drug Central 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
CHEMBL14376 8787 111 None -323 44 Human 8.3 pKi None 8.3 Binding
NoneNone
Drug Central 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
DB04946 8787 111 None -323 44 Human 8.3 pKi None 8.3 Binding
NoneNone
Drug Central 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
885 10620 0 None -1584 2 Rat 5.7 pKi None 5.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 619 10 3 6 5.1 O=C([C@@H](NC(=O)c1cc2c([nH]1)cccc2)CSc1ncccc1C(=O)O)N1CCN(CC1)C(c1ccccc1)c1ccccc1 8730754
9873836 10620 0 None -1584 2 Rat 5.7 pKi None 5.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 619 10 3 6 5.1 O=C([C@@H](NC(=O)c1cc2c([nH]1)cccc2)CSc1ncccc1C(=O)O)N1CCN(CC1)C(c1ccccc1)c1ccccc1 8730754
859 7260 0 None -7943 2 Rat 6.6 pKi None 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9476993
896 7378 0 None - 1 Rat 7.4 pKi None 7.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1614411
906 10153 0 None - 1 Rat 8.0 pKi None 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 474 9 3 4 3.1 O=C(Nc1cccc(c1)CC(=O)O)NCC(=O)N(c1ccccc1)CC(=O)N(c1ccccc1)C 7813588
9847721 10153 0 None - 1 Rat 8.0 pKi None 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 474 9 3 4 3.1 O=C(Nc1cccc(c1)CC(=O)O)NCC(=O)N(c1ccccc1)CC(=O)N(c1ccccc1)C 7813588
901 7094 0 None - 1 Human 8.3 pKi None 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 544 11 3 5 5.1 CCOC(CN1c2ccccc2[C@@](C1=O)(CC(=O)Nc1ccc(cc1)C)NC(=O)Nc1ccc(cc1)C)OCC 11738246
9807431 7094 0 None - 1 Human 8.3 pKi None 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 544 11 3 5 5.1 CCOC(CN1c2ccccc2[C@@](C1=O)(CC(=O)Nc1ccc(cc1)C)NC(=O)Nc1ccc(cc1)C)OCC 11738246
895 7377 0 None - 1 Rat 8.6 pKi None 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 14698161
907 10902 0 None - 1 Human 9.3 pKi None 9.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 520 6 3 5 4.7 O=C(N[C@@H]1CN(C2CCCCC2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2)Nc1cccc(c1)C(=O)O 17901954
9872609 10902 0 None - 1 Human 9.3 pKi None 9.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 520 6 3 5 4.7 O=C(N[C@@H]1CN(C2CCCCC2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2)Nc1cccc(c1)C(=O)O 17901954
CHEMBL4303633 10902 0 None - 1 Human 9.3 pKi None 9.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 520 6 3 5 4.7 O=C(N[C@@H]1CN(C2CCCCC2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2)Nc1cccc(c1)C(=O)O 17901954
887 10882 33 None -1 4 Human 9.6 pKi None 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 11738246
9870520 10882 33 None -1 4 Human 9.6 pKi None 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 11738246
CHEMBL324547 10882 33 None -1 4 Human 9.6 pKi None 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 11738246
DB12355 10882 33 None -1 4 Human 9.6 pKi None 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 11738246