Ligand source activities (1 row/activity)
Ligands (move mouse cursor over ligand name to see structure) | Receptor | Assay information | Chemical information | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name |
GPCRdb ID |
#Vendors |
Reference ligand |
Fold selectivity |
# Tested GPCRs |
Species |
p-value (-log) |
Activity Type |
Activity Relation |
Activity Value |
AssayType |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
CHEMBL2064011 | 215950 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6 | Functional | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)[C@@H](C)O | 10.1021/jm201609k | ||||
CHEMBL1170042 | 215327 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
CHEMBL1170045 | 215330 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6 | Functional | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/jm1003705 | ||||
CHEMBL1170640 | 215350 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
CHEMBL1170231 | 215337 | 0 | None | - | 1 | Human | 5.0 | pEC50 | = | 5.0 | Functional | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@@H](N)CCc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)[C@@H](C)O | 10.1021/jm1003705 | ||||
CHEMBL5081621 | 221535 | 0 | None | 4 | 2 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/acs.jmedchem.1c01174 | ||||
CHEMBL1170045 | 215330 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/jm1003705 | ||||
CHEMBL1170231 | 215337 | 0 | None | - | 1 | Human | 5.0 | pEC50 | = | 5.0 | Functional | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@@H](N)CCc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)[C@@H](C)O | 10.1021/jm1003705 | ||||
CHEMBL1170635 | 215345 | 0 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
CHEMBL1170635 | 215345 | 0 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
101886248 | 121752 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 434 | 10 | 6 | 4 | 2.0 | N=C(N)NCCC[C@H](NC(=O)c1c[nH]c(C(c2ccccc2)c2ccccc2)n1)C(=O)O | 10.1021/jm500956p | ||
CHEMBL3342688 | 121752 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 434 | 10 | 6 | 4 | 2.0 | N=C(N)NCCC[C@H](NC(=O)c1c[nH]c(C(c2ccccc2)c2ccccc2)n1)C(=O)O | 10.1021/jm500956p | ||
44426497 | 92510 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 502 | 10 | 5 | 4 | 4.2 | N=C(N)NCCC[C@@H](NC(=O)c1ccc(C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)o1)C(=O)O | 10.1016/j.bmcl.2007.04.022 | ||
CHEMBL229006 | 92510 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 502 | 10 | 5 | 4 | 4.2 | N=C(N)NCCC[C@@H](NC(=O)c1ccc(C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)o1)C(=O)O | 10.1016/j.bmcl.2007.04.022 | ||
CHEMBL1170026 | 215318 | 0 | None | 48 | 2 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N(C)[C@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/jm1003705 | ||||
3915 | 8307 | 11 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
49799079 | 8307 | 11 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
5760 | 8307 | 11 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
91933514 | 8307 | 11 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
CHEMBL1170024 | 8307 | 11 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
CHEMBL1170027 | 215319 | 0 | None | 30 | 2 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CC(=O)O)N(C)C(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/jm1003705 | ||||
44426495 | 92509 | 0 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 470 | 10 | 5 | 4 | 3.2 | N=C(N)NCCC[C@@H](NC(=O)c1ccc(C(c2cccc(F)c2)c2cccc(F)c2)o1)C(=O)O | 10.1016/j.bmcl.2007.04.022 | ||
CHEMBL229005 | 92509 | 0 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 470 | 10 | 5 | 4 | 3.2 | N=C(N)NCCC[C@@H](NC(=O)c1ccc(C(c2cccc(F)c2)c2cccc(F)c2)o1)C(=O)O | 10.1016/j.bmcl.2007.04.022 | ||
CHEMBL5080181 | 221447 | 0 | None | -3 | 2 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/acs.jmedchem.1c01174 | ||||
101886248 | 121752 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 434 | 10 | 6 | 4 | 2.0 | N=C(N)NCCC[C@H](NC(=O)c1c[nH]c(C(c2ccccc2)c2ccccc2)n1)C(=O)O | 10.1021/jm500956p | ||
CHEMBL3342688 | 121752 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 434 | 10 | 6 | 4 | 2.0 | N=C(N)NCCC[C@H](NC(=O)c1c[nH]c(C(c2ccccc2)c2ccccc2)n1)C(=O)O | 10.1021/jm500956p | ||
CHEMBL1170026 | 215318 | 0 | None | 48 | 2 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N(C)[C@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/jm1003705 | ||||
3915 | 8307 | 11 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
49799079 | 8307 | 11 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
5760 | 8307 | 11 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
91933514 | 8307 | 11 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
CHEMBL1170024 | 8307 | 11 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
CHEMBL1170027 | 215319 | 0 | None | 30 | 2 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CC(=O)O)N(C)C(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/jm1003705 | ||||
CHEMBL5075364 | 221149 | 0 | None | -2511 | 3 | Human | 4.8 | pEC50 | = | 4.8 | Functional | ChEMBL | None | None | None | CC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/acs.jmedchem.1c01174 | ||||
CHEMBL2064020 | 215959 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/jm201609k | ||||
122392665 | 172220 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 457 | 10 | 6 | 5 | 3.3 | N=C(N)NCCC[C@H](Nc1nccc2[nH]c(C(c3ccccc3)c3ccccc3)nc12)C(=O)O | 10.1021/acs.jmedchem.7b00882 | ||
CHEMBL4239035 | 172220 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 457 | 10 | 6 | 5 | 3.3 | N=C(N)NCCC[C@H](Nc1nccc2[nH]c(C(c3ccccc3)c3ccccc3)nc12)C(=O)O | 10.1021/acs.jmedchem.7b00882 | ||
17753143 | 92715 | 4 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 434 | 10 | 5 | 4 | 2.9 | N=C(N)NCCC[C@H](NC(=O)c1ccc(C(c2ccccc2)c2ccccc2)o1)C(=O)O | 10.1016/j.bmcl.2007.04.022 | ||
CHEMBL230034 | 92715 | 4 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 434 | 10 | 5 | 4 | 2.9 | N=C(N)NCCC[C@H](NC(=O)c1ccc(C(c2ccccc2)c2ccccc2)o1)C(=O)O | 10.1016/j.bmcl.2007.04.022 | ||
44430551 | 94779 | 0 | None | - | 1 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 483 | 7 | 1 | 3 | 5.6 | O=C(NC1CCN(C(=O)CCc2cccnc2)CC1)C(c1ccc2ccccc2c1)C1CCCCC1 | 10.1016/j.bmcl.2007.04.023 | ||
CHEMBL234305 | 94779 | 0 | None | - | 1 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 483 | 7 | 1 | 3 | 5.6 | O=C(NC1CCN(C(=O)CCc2cccnc2)CC1)C(c1ccc2ccccc2c1)C1CCCCC1 | 10.1016/j.bmcl.2007.04.023 | ||
CHEMBL1170025 | 215317 | 0 | None | -1 | 2 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
44426475 | 151447 | 0 | None | - | 1 | Human | 4.8 | pEC50 | = | 4.8 | Functional | ChEMBL | 394 | 8 | 5 | 4 | 2.5 | N=C(N)NCCC[C@@H](NC(=O)c1ccc(-c2cccc(Cl)c2)s1)C(=O)O | 10.1016/j.bmcl.2007.04.022 | ||
CHEMBL390834 | 151447 | 0 | None | - | 1 | Human | 4.8 | pEC50 | = | 4.8 | Functional | ChEMBL | 394 | 8 | 5 | 4 | 2.5 | N=C(N)NCCC[C@@H](NC(=O)c1ccc(-c2cccc(Cl)c2)s1)C(=O)O | 10.1016/j.bmcl.2007.04.022 | ||
CHEMBL2064012 | 215951 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/jm201609k | ||||
71525749 | 143207 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 537 | 12 | 6 | 7 | 1.8 | CC[C@H](C)[C@H](NC(=O)c1cncc(Br)c1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | ||
CHEMBL3735507 | 143207 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 537 | 12 | 6 | 7 | 1.8 | CC[C@H](C)[C@H](NC(=O)c1cncc(Br)c1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | ||
71525749 | 143207 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 537 | 12 | 6 | 7 | 1.8 | CC[C@H](C)[C@H](NC(=O)c1cncc(Br)c1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | ||
CHEMBL3735507 | 143207 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 537 | 12 | 6 | 7 | 1.8 | CC[C@H](C)[C@H](NC(=O)c1cncc(Br)c1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | ||
CHEMBL5080381 | 221460 | 0 | None | -47 | 2 | Human | 4.8 | pEC50 | = | 4.8 | Functional | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/acs.jmedchem.1c01174 | ||||
CHEMBL1170025 | 215317 | 0 | None | -1 | 2 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
CHEMBL1170043 | 215328 | 0 | None | - | 1 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/jm1003705 | ||||
71768012 | 143230 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 454 | 11 | 6 | 7 | 1.7 | CC(C)C[C@H](NC(=O)OC(C)(C)C)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | ||
CHEMBL3735760 | 143230 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 454 | 11 | 6 | 7 | 1.7 | CC(C)C[C@H](NC(=O)OC(C)(C)C)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | ||
71768012 | 143230 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 454 | 11 | 6 | 7 | 1.7 | CC(C)C[C@H](NC(=O)OC(C)(C)C)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | ||
CHEMBL3735760 | 143230 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 454 | 11 | 6 | 7 | 1.7 | CC(C)C[C@H](NC(=O)OC(C)(C)C)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | ||
44426496 | 148820 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 502 | 10 | 5 | 4 | 4.2 | N=C(N)NCCC[C@@H](NC(=O)c1ccc(C(c2cccc(Cl)c2)c2cccc(Cl)c2)o1)C(=O)O | 10.1016/j.bmcl.2007.04.022 | ||
CHEMBL387755 | 148820 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 502 | 10 | 5 | 4 | 4.2 | N=C(N)NCCC[C@@H](NC(=O)c1ccc(C(c2cccc(Cl)c2)c2cccc(Cl)c2)o1)C(=O)O | 10.1016/j.bmcl.2007.04.022 | ||
CHEMBL2063898 | 215949 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)[C@@H](C)O | 10.1021/jm201609k | ||||
44430554 | 158048 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 451 | 7 | 1 | 3 | 4.6 | O=C(NC1CCN(C(=O)CCc2cccnc2F)CC1)C(c1ccccc1)C1CCCCC1 | 10.1016/j.bmcl.2007.04.023 | ||
CHEMBL396031 | 158048 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 451 | 7 | 1 | 3 | 4.6 | O=C(NC1CCN(C(=O)CCc2cccnc2F)CC1)C(c1ccccc1)C1CCCCC1 | 10.1016/j.bmcl.2007.04.023 | ||
44430547 | 175638 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 465 | 7 | 1 | 3 | 4.9 | O=C(NC1CCN(C(=O)CCc2cccnc2)CC1)C(c1cccc(Cl)c1)C1C=CCCC1 | 10.1016/j.bmcl.2007.04.023 | ||
CHEMBL438129 | 175638 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 465 | 7 | 1 | 3 | 4.9 | O=C(NC1CCN(C(=O)CCc2cccnc2)CC1)C(c1cccc(Cl)c1)C1C=CCCC1 | 10.1016/j.bmcl.2007.04.023 | ||
CHEMBL1170029 | 215321 | 0 | None | 29 | 2 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/jm1003705 | ||||
11252 | 7557 | 39 | None | - | 1 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 433 | 7 | 1 | 3 | 4.5 | O=C(N1CCC(CC1)NC(=O)C(c1ccccc1)C1CCCCC1)CCc1cccnc1 | 10.1016/j.bmcl.2007.04.023 | ||
44430519 | 7557 | 39 | None | - | 1 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 433 | 7 | 1 | 3 | 4.5 | O=C(N1CCC(CC1)NC(=O)C(c1ccccc1)C1CCCCC1)CCc1cccnc1 | 10.1016/j.bmcl.2007.04.023 | ||
CHEMBL390036 | 7557 | 39 | None | - | 1 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 433 | 7 | 1 | 3 | 4.5 | O=C(N1CCC(CC1)NC(=O)C(c1ccccc1)C1CCCCC1)CCc1cccnc1 | 10.1016/j.bmcl.2007.04.023 | ||
CHEMBL1170034 | 215325 | 0 | None | - | 1 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)[C@@H](CC1CCCCC1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1ccccc1)C(N)=O | 10.1021/jm1003705 | ||||
CHEMBL1170043 | 215328 | 0 | None | - | 1 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/jm1003705 | ||||
8381 | 7816 | 3 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 448 | 10 | 6 | 4 | 2.3 | O=C(c1nc([nH]c1C)C(c1ccccc1)c1ccccc1)N[C@H](C(=O)O)CCCNC(=N)N | 10.1021/jm500956p | ||
91827354 | 7816 | 3 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 448 | 10 | 6 | 4 | 2.3 | O=C(c1nc([nH]c1C)C(c1ccccc1)c1ccccc1)N[C@H](C(=O)O)CCCNC(=N)N | 10.1021/jm500956p | ||
CHEMBL3342689 | 7816 | 3 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 448 | 10 | 6 | 4 | 2.3 | O=C(c1nc([nH]c1C)C(c1ccccc1)c1ccccc1)N[C@H](C(=O)O)CCCNC(=N)N | 10.1021/jm500956p | ||
CHEMBL1170029 | 215321 | 0 | None | 29 | 2 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/jm1003705 | ||||
CHEMBL1170034 | 215325 | 0 | None | - | 1 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)[C@@H](CC1CCCCC1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1ccccc1)C(N)=O | 10.1021/jm1003705 | ||||
CHEMBL2064018 | 215957 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/jm201609k | ||||
89570392 | 143255 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 512 | 12 | 6 | 6 | 2.4 | CC[C@H](C)[C@H](NC(=O)C1CCCc2ccccc21)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | ||
CHEMBL3736020 | 143255 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 512 | 12 | 6 | 6 | 2.4 | CC[C@H](C)[C@H](NC(=O)C1CCCc2ccccc21)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | ||
89570392 | 143255 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 512 | 12 | 6 | 6 | 2.4 | CC[C@H](C)[C@H](NC(=O)C1CCCc2ccccc21)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | ||
CHEMBL3736020 | 143255 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 512 | 12 | 6 | 6 | 2.4 | CC[C@H](C)[C@H](NC(=O)C1CCCc2ccccc21)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | ||
CHEMBL1169838 | 215316 | 0 | None | -6 | 2 | Human | 4.6 | pEC50 | = | 4.6 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
CHEMBL1170433 | 215341 | 0 | None | - | 1 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
8381 | 7816 | 3 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 448 | 10 | 6 | 4 | 2.3 | O=C(c1nc([nH]c1C)C(c1ccccc1)c1ccccc1)N[C@H](C(=O)O)CCCNC(=N)N | 10.1021/jm500956p | ||
91827354 | 7816 | 3 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 448 | 10 | 6 | 4 | 2.3 | O=C(c1nc([nH]c1C)C(c1ccccc1)c1ccccc1)N[C@H](C(=O)O)CCCNC(=N)N | 10.1021/jm500956p | ||
CHEMBL3342689 | 7816 | 3 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 448 | 10 | 6 | 4 | 2.3 | O=C(c1nc([nH]c1C)C(c1ccccc1)c1ccccc1)N[C@H](C(=O)O)CCCNC(=N)N | 10.1021/jm500956p | ||
CHEMBL2064016 | 215955 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)[C@@H](C)O | 10.1021/jm201609k | ||||
CHEMBL1170433 | 215341 | 0 | None | - | 1 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
CHEMBL1170229 | 215335 | 0 | None | - | 1 | Human | 4.6 | pEC50 | = | 4.6 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
CHEMBL1169838 | 215316 | 0 | None | -6 | 2 | Human | 4.6 | pEC50 | = | 4.6 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
CHEMBL1170229 | 215335 | 0 | None | - | 1 | Human | 4.6 | pEC50 | = | 4.6 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
71566581 | 143282 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 454 | 11 | 6 | 7 | 1.7 | CC[C@H](C)[C@H](NC(=O)OC(C)(C)C)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | ||
CHEMBL3736239 | 143282 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 454 | 11 | 6 | 7 | 1.7 | CC[C@H](C)[C@H](NC(=O)OC(C)(C)C)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | ||
CHEMBL1170643 | 215352 | 0 | None | - | 1 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)Cc1ccccc1)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/jm1003705 | ||||
CHEMBL2064018 | 215957 | 0 | None | - | 1 | Human | 4.6 | pEC50 | = | 4.6 | Functional | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/jm201609k | ||||
71566581 | 143282 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 454 | 11 | 6 | 7 | 1.7 | CC[C@H](C)[C@H](NC(=O)OC(C)(C)C)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | ||
CHEMBL3736239 | 143282 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 454 | 11 | 6 | 7 | 1.7 | CC[C@H](C)[C@H](NC(=O)OC(C)(C)C)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | ||
CHEMBL1170643 | 215352 | 0 | None | - | 1 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)Cc1ccccc1)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/jm1003705 | ||||
CHEMBL5092449 | 222147 | 0 | None | 2 | 2 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/acs.jmedchem.1c01174 | ||||
CHEMBL1170648 | 215355 | 0 | None | - | 1 | Human | 4.5 | pEC50 | = | 4.5 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
CHEMBL1170648 | 215355 | 0 | None | - | 1 | Human | 4.5 | pEC50 | = | 4.5 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
CHEMBL5087237 | 221859 | 0 | None | -446 | 2 | Human | 5.5 | pEC50 | = | 5.5 | Functional | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C | 10.1021/acs.jmedchem.1c01174 | ||||
CHEMBL1170437 | 215343 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)[C@@H](C)O | 10.1021/jm1003705 | ||||
CHEMBL1170437 | 215343 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)[C@@H](C)O | 10.1021/jm1003705 | ||||
CHEMBL1170638 | 215348 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
CHEMBL1170035 | 215326 | 0 | None | - | 1 | Human | 4.5 | pEC50 | = | 4.5 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
CHEMBL1170638 | 215348 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2015.10.038 | ||||
CHEMBL1170638 | 215348 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
CHEMBL1170035 | 215326 | 0 | None | - | 1 | Human | 4.5 | pEC50 | = | 4.5 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
CHEMBL2064014 | 215953 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)[C@@H](C)O)[C@@H](C)O | 10.1021/jm201609k | ||||
CHEMBL2064019 | 215958 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/jm201609k | ||||
CHEMBL1170641 | 215351 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
CHEMBL1170641 | 215351 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
CHEMBL1170650 | 215356 | 0 | None | - | 1 | Human | 4.4 | pEC50 | = | 4.4 | Functional | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)[C@@H](C)O | 10.1021/jm1003705 | ||||
CHEMBL5080234 | 221450 | 0 | None | -3 | 2 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1ccccc1)[C@@H](C)O)C(=O)N[C@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/acs.jmedchem.1c01174 | ||||
CHEMBL1170637 | 215347 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
CHEMBL1170650 | 215356 | 0 | None | - | 1 | Human | 4.4 | pEC50 | = | 4.4 | Functional | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)[C@@H](C)O | 10.1021/jm1003705 | ||||
CHEMBL1170637 | 215347 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
CHEMBL5085743 | 221765 | 0 | None | -51 | 2 | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/acs.jmedchem.1c01174 | ||||
CHEMBL1170030 | 215322 | 11 | None | - | 1 | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
CHEMBL1170221 | 215333 | 0 | None | - | 1 | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
CHEMBL1170223 | 215334 | 0 | None | - | 1 | Human | 4.4 | pEC50 | = | 4.4 | Functional | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/jm1003705 | ||||
101886250 | 121753 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 462 | 10 | 5 | 5 | 2.4 | Cc1c(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)nc(C(c2ccccc2)c2ccccc2)n1C | 10.1021/jm500956p | ||
CHEMBL3342690 | 121753 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 462 | 10 | 5 | 5 | 2.4 | Cc1c(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)nc(C(c2ccccc2)c2ccccc2)n1C | 10.1021/jm500956p | ||
49799093 | 8433 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
5761 | 8433 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
CHEMBL1172879 | 8433 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
CHEMBL1170030 | 215322 | 11 | None | - | 1 | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
CHEMBL1170221 | 215333 | 0 | None | - | 1 | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
44426472 | 92479 | 0 | None | - | 1 | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 388 | 8 | 5 | 3 | 2.5 | N=C(N)NCCC[C@@H](NC(=O)c1cccc(-c2cccc(Cl)c2)c1)C(=O)O | 10.1016/j.bmcl.2007.04.022 | ||
CHEMBL228847 | 92479 | 0 | None | - | 1 | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 388 | 8 | 5 | 3 | 2.5 | N=C(N)NCCC[C@@H](NC(=O)c1cccc(-c2cccc(Cl)c2)c1)C(=O)O | 10.1016/j.bmcl.2007.04.022 | ||
CHEMBL1170223 | 215334 | 0 | None | - | 1 | Human | 4.4 | pEC50 | = | 4.4 | Functional | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/jm1003705 | ||||
101886250 | 121753 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 462 | 10 | 5 | 5 | 2.4 | Cc1c(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)nc(C(c2ccccc2)c2ccccc2)n1C | 10.1021/jm500956p | ||
CHEMBL3342690 | 121753 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 462 | 10 | 5 | 5 | 2.4 | Cc1c(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)nc(C(c2ccccc2)c2ccccc2)n1C | 10.1021/jm500956p | ||
127036518 | 143153 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 509 | 12 | 6 | 7 | 2.2 | CC[C@H](C)[C@H](NC(=O)c1ccc2ccccc2n1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | ||
CHEMBL3735048 | 143153 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 509 | 12 | 6 | 7 | 2.2 | CC[C@H](C)[C@H](NC(=O)c1ccc2ccccc2n1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | ||
127036518 | 143153 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 509 | 12 | 6 | 7 | 2.2 | CC[C@H](C)[C@H](NC(=O)c1ccc2ccccc2n1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | ||
CHEMBL3735048 | 143153 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 509 | 12 | 6 | 7 | 2.2 | CC[C@H](C)[C@H](NC(=O)c1ccc2ccccc2n1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | ||
49799093 | 8433 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
5761 | 8433 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
CHEMBL1172879 | 8433 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
CHEMBL5082686 | 221599 | 0 | None | -275 | 2 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | None | None | None | CC[C@@H](C)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/acs.jmedchem.1c01174 | ||||
CHEMBL5093227 | 222196 | 0 | None | -99 | 2 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/acs.jmedchem.1c01174 | ||||
127034744 | 143184 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 468 | 11 | 6 | 7 | 2.0 | Cc1oc([C@H](CC(C)C)NC(=O)OC(C)(C)C)nc1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1016/j.bmcl.2015.10.038 | ||
CHEMBL3735339 | 143184 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 468 | 11 | 6 | 7 | 2.0 | Cc1oc([C@H](CC(C)C)NC(=O)OC(C)(C)C)nc1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1016/j.bmcl.2015.10.038 | ||
CHEMBL1170438 | 215344 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
CHEMBL1170438 | 215344 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
CHEMBL1170436 | 215342 | 0 | None | - | 1 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
CHEMBL1170436 | 215342 | 0 | None | - | 1 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
CHEMBL2064017 | 215956 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)[C@@H](C)O | 10.1021/jm201609k | ||||
CHEMBL1170636 | 215346 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
CHEMBL1170636 | 215346 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
71565510 | 143171 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 566 | 14 | 6 | 7 | 3.3 | CC[C@H](C)[C@H](NC(=O)C(C)c1ccc2cc(OC)ccc2c1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | ||
CHEMBL3735240 | 143171 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 566 | 14 | 6 | 7 | 3.3 | CC[C@H](C)[C@H](NC(=O)C(C)c1ccc2cc(OC)ccc2c1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | ||
71566652 | 143316 | 0 | None | - | 1 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 458 | 12 | 6 | 6 | 1.6 | CC[C@H](C)[C@H](NC(=O)c1ccccc1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | ||
CHEMBL3736519 | 143316 | 0 | None | - | 1 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 458 | 12 | 6 | 6 | 1.6 | CC[C@H](C)[C@H](NC(=O)c1ccccc1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | ||
44426463 | 93169 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 378 | 8 | 5 | 4 | 2.0 | N=C(N)NCCC[C@@H](NC(=O)c1ccc(-c2cccc(Cl)c2)o1)C(=O)O | 10.1016/j.bmcl.2007.04.022 | ||
CHEMBL231405 | 93169 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 378 | 8 | 5 | 4 | 2.0 | N=C(N)NCCC[C@@H](NC(=O)c1ccc(-c2cccc(Cl)c2)o1)C(=O)O | 10.1016/j.bmcl.2007.04.022 | ||
71565510 | 143171 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 566 | 14 | 6 | 7 | 3.3 | CC[C@H](C)[C@H](NC(=O)C(C)c1ccc2cc(OC)ccc2c1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | ||
CHEMBL3735240 | 143171 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 566 | 14 | 6 | 7 | 3.3 | CC[C@H](C)[C@H](NC(=O)C(C)c1ccc2cc(OC)ccc2c1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | ||
71566652 | 143316 | 0 | None | - | 1 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 458 | 12 | 6 | 6 | 1.6 | CC[C@H](C)[C@H](NC(=O)c1ccccc1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | ||
CHEMBL3736519 | 143316 | 0 | None | - | 1 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 458 | 12 | 6 | 6 | 1.6 | CC[C@H](C)[C@H](NC(=O)c1ccccc1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | ||
CHEMBL1170044 | 215329 | 0 | None | - | 1 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
CHEMBL1173027 | 215368 | 0 | None | - | 1 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
CHEMBL1170639 | 215349 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
CHEMBL1170232 | 215338 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)[C@@H](C)O | 10.1021/jm1003705 | ||||
CHEMBL1170639 | 215349 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
117634952 | 143312 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 490 | 13 | 6 | 6 | 1.7 | CC(C)C[C@H](NC(=O)Cc1ccc(F)cc1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | ||
CHEMBL3736505 | 143312 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 490 | 13 | 6 | 6 | 1.7 | CC(C)C[C@H](NC(=O)Cc1ccc(F)cc1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | ||
CHEMBL1170232 | 215338 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)[C@@H](C)O | 10.1021/jm1003705 | ||||
117634952 | 143312 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 490 | 13 | 6 | 6 | 1.7 | CC(C)C[C@H](NC(=O)Cc1ccc(F)cc1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | ||
CHEMBL3736505 | 143312 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 490 | 13 | 6 | 6 | 1.7 | CC(C)C[C@H](NC(=O)Cc1ccc(F)cc1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | ||
CHEMBL1170044 | 215329 | 0 | None | - | 1 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
CHEMBL5083558 | 221649 | 0 | None | 2 | 2 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](C)N)C(=O)N[C@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/acs.jmedchem.1c01174 | ||||
71565582 | 143232 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 550 | 14 | 6 | 7 | 3.4 | CC[C@H](C)[C@H](NC(=O)c1ccccc1Oc1ccccc1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | ||
CHEMBL3735764 | 143232 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 550 | 14 | 6 | 7 | 3.4 | CC[C@H](C)[C@H](NC(=O)c1ccccc1Oc1ccccc1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | ||
71565582 | 143232 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 550 | 14 | 6 | 7 | 3.4 | CC[C@H](C)[C@H](NC(=O)c1ccccc1Oc1ccccc1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | ||
CHEMBL3735764 | 143232 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 550 | 14 | 6 | 7 | 3.4 | CC[C@H](C)[C@H](NC(=O)c1ccccc1Oc1ccccc1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | ||
CHEMBL1173027 | 215368 | 0 | None | - | 1 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
CHEMBL5078171 | 221318 | 0 | None | -436 | 2 | Human | 4.3 | pEC50 | = | 4.3 | Functional | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/acs.jmedchem.1c01174 | ||||
CHEMBL5071478 | 221038 | 6 | None | -933 | 3 | Human | 4.3 | pEC50 | = | 4.3 | Functional | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/acs.jmedchem.1c01174 | ||||
71566653 | 143208 | 0 | None | - | 1 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 548 | 14 | 6 | 6 | 3.2 | CC[C@H](C)[C@H](NC(=O)C(c1ccccc1)c1ccccc1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | ||
CHEMBL3735554 | 143208 | 0 | None | - | 1 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 548 | 14 | 6 | 6 | 3.2 | CC[C@H](C)[C@H](NC(=O)C(c1ccccc1)c1ccccc1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | ||
71566653 | 143208 | 0 | None | - | 1 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 548 | 14 | 6 | 6 | 3.2 | CC[C@H](C)[C@H](NC(=O)C(c1ccccc1)c1ccccc1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | ||
CHEMBL3735554 | 143208 | 0 | None | - | 1 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 548 | 14 | 6 | 6 | 3.2 | CC[C@H](C)[C@H](NC(=O)C(c1ccccc1)c1ccccc1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | ||
CHEMBL1170028 | 215320 | 0 | None | - | 1 | Human | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/jm1003705 | ||||
CHEMBL2021602 | 215909 | 0 | None | - | 1 | Human | 4.2 | pEC50 | = | 4.2 | Functional | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](CCCNC(=N)N)C(=O)O)C(C)C | 10.1021/jm1003705 | ||||
CHEMBL2021602 | 215909 | 0 | None | - | 1 | Human | 4.2 | pEC50 | = | 4.2 | Functional | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](CCCNC(=N)N)C(=O)O)C(C)C | 10.1021/jm1003705 | ||||
CHEMBL1170046 | 215331 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
CHEMBL5085196 | 221734 | 0 | None | -3 | 2 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/acs.jmedchem.1c01174 | ||||
CHEMBL1170046 | 215331 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
CHEMBL5081287 | 221518 | 0 | None | 30 | 2 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](C)N)C(=O)N[C@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/acs.jmedchem.1c01174 | ||||
CHEMBL2064017 | 215956 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)[C@@H](C)O | 10.1021/jm201609k | ||||
CHEMBL2064019 | 215958 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/jm201609k | ||||
CHEMBL2064013 | 215952 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/jm201609k | ||||
CHEMBL1170349 | 215339 | 0 | None | - | 1 | Human | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
CHEMBL1170349 | 215339 | 0 | None | - | 1 | Human | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
CHEMBL5092461 | 222149 | 0 | None | -2041 | 2 | Human | 4.2 | pEC50 | = | 4.2 | Functional | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)[C@@H](C)O | 10.1021/acs.jmedchem.1c01174 | ||||
71566654 | 7792 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 497 | 12 | 6 | 6 | 1.9 | CC(C[C@@H](c1occ(n1)C(=O)N[C@H](C(=O)O)CCCN=C(N)N)NC(=O)c1c[nH]c2c1cccc2)C | 10.1021/acs.jmedchem.7b00882 | ||
9449 | 7792 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 497 | 12 | 6 | 6 | 1.9 | CC(C[C@@H](c1occ(n1)C(=O)N[C@H](C(=O)O)CCCN=C(N)N)NC(=O)c1c[nH]c2c1cccc2)C | 10.1021/acs.jmedchem.7b00882 | ||
CHEMBL3736108 | 7792 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 497 | 12 | 6 | 6 | 1.9 | CC(C[C@@H](c1occ(n1)C(=O)N[C@H](C(=O)O)CCCN=C(N)N)NC(=O)c1c[nH]c2c1cccc2)C | 10.1021/acs.jmedchem.7b00882 | ||
71566654 | 7792 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 497 | 12 | 6 | 6 | 1.9 | CC(C[C@@H](c1occ(n1)C(=O)N[C@H](C(=O)O)CCCN=C(N)N)NC(=O)c1c[nH]c2c1cccc2)C | 10.1016/j.bmcl.2015.10.038 | ||
9449 | 7792 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 497 | 12 | 6 | 6 | 1.9 | CC(C[C@@H](c1occ(n1)C(=O)N[C@H](C(=O)O)CCCN=C(N)N)NC(=O)c1c[nH]c2c1cccc2)C | 10.1016/j.bmcl.2015.10.038 | ||
CHEMBL3736108 | 7792 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 497 | 12 | 6 | 6 | 1.9 | CC(C[C@@H](c1occ(n1)C(=O)N[C@H](C(=O)O)CCCN=C(N)N)NC(=O)c1c[nH]c2c1cccc2)C | 10.1016/j.bmcl.2015.10.038 | ||
71566654 | 7792 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 497 | 12 | 6 | 6 | 1.9 | CC(C[C@@H](c1occ(n1)C(=O)N[C@H](C(=O)O)CCCN=C(N)N)NC(=O)c1c[nH]c2c1cccc2)C | 10.1016/j.bmcl.2015.10.038 | ||
9449 | 7792 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 497 | 12 | 6 | 6 | 1.9 | CC(C[C@@H](c1occ(n1)C(=O)N[C@H](C(=O)O)CCCN=C(N)N)NC(=O)c1c[nH]c2c1cccc2)C | 10.1016/j.bmcl.2015.10.038 | ||
CHEMBL3736108 | 7792 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 497 | 12 | 6 | 6 | 1.9 | CC(C[C@@H](c1occ(n1)C(=O)N[C@H](C(=O)O)CCCN=C(N)N)NC(=O)c1c[nH]c2c1cccc2)C | 10.1016/j.bmcl.2015.10.038 | ||
71565580 | 143262 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 590 | 16 | 6 | 7 | 3.7 | CC[C@H](C)[C@H](NC(=O)CCC(=O)c1ccc(-c2ccccc2)cc1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | ||
CHEMBL3736125 | 143262 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 590 | 16 | 6 | 7 | 3.7 | CC[C@H](C)[C@H](NC(=O)CCC(=O)c1ccc(-c2ccccc2)cc1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | ||
CHEMBL5079833 | 221425 | 0 | None | -7 | 2 | Human | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | None | None | None | C[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1ccccc1)[C@@H](C)O)C(=O)N[C@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/acs.jmedchem.1c01174 | ||||
CHEMBL2064015 | 215954 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)[C@@H](C)O)[C@@H](C)O | 10.1021/jm201609k | ||||
71565506 | 143254 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 511 | 13 | 7 | 6 | 2.0 | CC[C@H](C)[C@H](NC(=O)Cc1c[nH]c2ccccc12)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | ||
CHEMBL3735993 | 143254 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 511 | 13 | 7 | 6 | 2.0 | CC[C@H](C)[C@H](NC(=O)Cc1c[nH]c2ccccc12)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | ||
CHEMBL1170220 | 215332 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/jm1003705 | ||||
71565506 | 143254 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 511 | 13 | 7 | 6 | 2.0 | CC[C@H](C)[C@H](NC(=O)Cc1c[nH]c2ccccc12)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | ||
CHEMBL3735993 | 143254 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 511 | 13 | 7 | 6 | 2.0 | CC[C@H](C)[C@H](NC(=O)Cc1c[nH]c2ccccc12)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | ||
117634979 | 143133 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 502 | 13 | 6 | 6 | 2.5 | CC[C@H](C)[C@H](NC(=O)C1(C(C)C)C=CCC=C1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | ||
CHEMBL3734832 | 143133 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 502 | 13 | 6 | 6 | 2.5 | CC[C@H](C)[C@H](NC(=O)C1(C(C)C)C=CCC=C1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | ||
117634979 | 143133 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 502 | 13 | 6 | 6 | 2.5 | CC[C@H](C)[C@H](NC(=O)C1(C(C)C)C=CCC=C1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | ||
CHEMBL3734832 | 143133 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 502 | 13 | 6 | 6 | 2.5 | CC[C@H](C)[C@H](NC(=O)C1(C(C)C)C=CCC=C1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | ||
CHEMBL5092578 | 222155 | 0 | None | -295 | 2 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | None | None | None | CCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/acs.jmedchem.1c01174 | ||||
CHEMBL1169603 | 215315 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC1CCCCC1)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/jm1003705 | ||||
CHEMBL2064016 | 215955 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)[C@@H](C)O | 10.1021/jm201609k | ||||
44430549 | 158045 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 487 | 7 | 1 | 3 | 4.9 | O=C(NC1CCN(C(=O)CCc2cccnc2)CC1)C(c1cc(F)c(F)c(F)c1)C1CCCCC1 | 10.1016/j.bmcl.2007.04.023 | ||
CHEMBL396030 | 158045 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 487 | 7 | 1 | 3 | 4.9 | O=C(NC1CCN(C(=O)CCc2cccnc2)CC1)C(c1cc(F)c(F)c(F)c1)C1CCCCC1 | 10.1016/j.bmcl.2007.04.023 | ||
CHEMBL1169603 | 215315 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC1CCCCC1)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/jm1003705 | ||||
CHEMBL1170220 | 215332 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/jm1003705 | ||||
71565580 | 143262 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 590 | 16 | 6 | 7 | 3.7 | CC[C@H](C)[C@H](NC(=O)CCC(=O)c1ccc(-c2ccccc2)cc1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | ||
CHEMBL3736125 | 143262 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 590 | 16 | 6 | 7 | 3.7 | CC[C@H](C)[C@H](NC(=O)CCC(=O)c1ccc(-c2ccccc2)cc1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | ||
CHEMBL2064021 | 215960 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | None | None | None | None | 10.1021/jm201609k | ||||
117637102 | 143308 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 518 | 14 | 6 | 8 | 1.7 | CC[C@H](C)[C@H](NC(=O)c1ccc(OC)cc1OC)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | ||
CHEMBL3736447 | 143308 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 518 | 14 | 6 | 8 | 1.7 | CC[C@H](C)[C@H](NC(=O)c1ccc(OC)cc1OC)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | ||
117637102 | 143308 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 518 | 14 | 6 | 8 | 1.7 | CC[C@H](C)[C@H](NC(=O)c1ccc(OC)cc1OC)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | ||
CHEMBL3736447 | 143308 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 518 | 14 | 6 | 8 | 1.7 | CC[C@H](C)[C@H](NC(=O)c1ccc(OC)cc1OC)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | ||
CHEMBL5076900 | 221247 | 0 | None | 2 | 2 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)Cc1ccccc1)[C@@H](C)O)C(=O)N[C@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/acs.jmedchem.1c01174 | ||||
CHEMBL1170230 | 215336 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
CHEMBL1170230 | 215336 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
CHEMBL1170042 | 215327 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | None | None | None | None | 10.1021/jm1003705 | ||||
8384 | 7897 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 428 | 12 | 5 | 4 | 2.4 | NC(=N)NCCC[C@@H](C(=O)O)NC(=O)CSCC(c1ccccc1)c1ccccc1 | 10.1021/jm500956p | ||
91827355 | 7897 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 428 | 12 | 5 | 4 | 2.4 | NC(=N)NCCC[C@@H](C(=O)O)NC(=O)CSCC(c1ccccc1)c1ccccc1 | 10.1021/jm500956p | ||
CHEMBL3342676 | 7897 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 428 | 12 | 5 | 4 | 2.4 | NC(=N)NCCC[C@@H](C(=O)O)NC(=O)CSCC(c1ccccc1)c1ccccc1 | 10.1021/jm500956p | ||
CHEMBL2064013 | 215952 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/jm201609k | ||||
10595 | 8934 | 21 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 532 | 10 | 5 | 4 | 5.0 | O=C(c1sc(cc1C)C(c1ccc(cc1)Cl)c1ccc(cc1)Cl)N[C@H](C(=O)O)CCCNC(=N)N | 10.1021/acs.jmedchem.9b00927 | ||
145996525 | 8934 | 21 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 532 | 10 | 5 | 4 | 5.0 | O=C(c1sc(cc1C)C(c1ccc(cc1)Cl)c1ccc(cc1)Cl)N[C@H](C(=O)O)CCCNC(=N)N | 10.1021/acs.jmedchem.9b00927 | ||
CHEMBL4459627 | 8934 | 21 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 532 | 10 | 5 | 4 | 5.0 | O=C(c1sc(cc1C)C(c1ccc(cc1)Cl)c1ccc(cc1)Cl)N[C@H](C(=O)O)CCCNC(=N)N | 10.1021/acs.jmedchem.9b00927 | ||
CHEMBL2064012 | 215951 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/jm201609k | ||||
155525092 | 177719 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 500 | 10 | 5 | 4 | 4.5 | N=C(N)NCCC[C@H](NC(=O)c1ccc(C(c2ccccc2)c2ccc3ccccc3c2)s1)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
CHEMBL4455385 | 177719 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 500 | 10 | 5 | 4 | 4.5 | N=C(N)NCCC[C@H](NC(=O)c1ccc(C(c2ccccc2)c2ccc3ccccc3c2)s1)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
155535693 | 178848 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 486 | 10 | 5 | 4 | 3.7 | N=C(N)NCCC[C@H](NC(=O)c1ccc(C(c2ccc(F)cc2)c2ccc(F)cc2)s1)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
CHEMBL4472149 | 178848 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 486 | 10 | 5 | 4 | 3.7 | N=C(N)NCCC[C@H](NC(=O)c1ccc(C(c2ccc(F)cc2)c2ccc(F)cc2)s1)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
155558856 | 181594 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 478 | 12 | 5 | 4 | 3.8 | N=C(N)NCCC[C@H](NC(=O)c1ccc(C(Cc2ccccc2)Cc2ccccc2)s1)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
CHEMBL4562412 | 181594 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 478 | 12 | 5 | 4 | 3.8 | N=C(N)NCCC[C@H](NC(=O)c1ccc(C(Cc2ccccc2)Cc2ccccc2)s1)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
101886254 | 121744 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6 | Functional | ChEMBL | 436 | 10 | 5 | 6 | 1.7 | N=C(N)NCCC[C@H](NC(=O)c1nc(C(c2ccccc2)c2ccccc2)no1)C(=O)O | 10.1021/jm500956p | ||
CHEMBL3342680 | 121744 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6 | Functional | ChEMBL | 436 | 10 | 5 | 6 | 1.7 | N=C(N)NCCC[C@H](NC(=O)c1nc(C(c2ccccc2)c2ccccc2)no1)C(=O)O | 10.1021/jm500956p | ||
101886249 | 121745 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6 | Functional | ChEMBL | 436 | 10 | 5 | 6 | 1.7 | N=C(N)NCCC[C@H](NC(=O)c1noc(C(c2ccccc2)c2ccccc2)n1)C(=O)O | 10.1021/jm500956p | ||
CHEMBL3342681 | 121745 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6 | Functional | ChEMBL | 436 | 10 | 5 | 6 | 1.7 | N=C(N)NCCC[C@H](NC(=O)c1noc(C(c2ccccc2)c2ccccc2)n1)C(=O)O | 10.1021/jm500956p | ||
CHEMBL2064019 | 215958 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/jm201609k | ||||
CHEMBL2064021 | 215960 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | None | None | None | None | 10.1021/jm201609k | ||||
101886249 | 121745 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 436 | 10 | 5 | 6 | 1.7 | N=C(N)NCCC[C@H](NC(=O)c1noc(C(c2ccccc2)c2ccccc2)n1)C(=O)O | 10.1021/jm500956p | ||
CHEMBL3342681 | 121745 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 436 | 10 | 5 | 6 | 1.7 | N=C(N)NCCC[C@H](NC(=O)c1noc(C(c2ccccc2)c2ccccc2)n1)C(=O)O | 10.1021/jm500956p | ||
155535683 | 178850 | 1 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 464 | 10 | 5 | 4 | 3.7 | Cc1cc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)sc1C(c1ccccc1)c1ccccc1 | 10.1021/acs.jmedchem.9b00927 | ||
CHEMBL4472196 | 178850 | 1 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 464 | 10 | 5 | 4 | 3.7 | Cc1cc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)sc1C(c1ccccc1)c1ccccc1 | 10.1021/acs.jmedchem.9b00927 | ||
155554899 | 181119 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 526 | 11 | 5 | 4 | 5.0 | N=C(N)NCCC[C@H](NC(=O)c1cc(-c2ccccc2)c(C(c2ccccc2)c2ccccc2)s1)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
CHEMBL4551058 | 181119 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 526 | 11 | 5 | 4 | 5.0 | N=C(N)NCCC[C@H](NC(=O)c1cc(-c2ccccc2)c(C(c2ccccc2)c2ccccc2)s1)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
3529 | 10290 | 9 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 412 | 12 | 4 | 4 | 1.5 | O=C(N[C@H](C(=O)O)CCCN=C(N)N)COCC(c1ccccc1)c1ccccc1 | 10.1021/jm500956p | ||
5311120 | 10290 | 9 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 412 | 12 | 4 | 4 | 1.5 | O=C(N[C@H](C(=O)O)CCCN=C(N)N)COCC(c1ccccc1)c1ccccc1 | 10.1021/jm500956p | ||
CHEMBL389348 | 10290 | 9 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 412 | 12 | 4 | 4 | 1.5 | O=C(N[C@H](C(=O)O)CCCN=C(N)N)COCC(c1ccccc1)c1ccccc1 | 10.1021/jm500956p | ||
101886254 | 121744 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 436 | 10 | 5 | 6 | 1.7 | N=C(N)NCCC[C@H](NC(=O)c1nc(C(c2ccccc2)c2ccccc2)no1)C(=O)O | 10.1021/jm500956p | ||
CHEMBL3342680 | 121744 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 436 | 10 | 5 | 6 | 1.7 | N=C(N)NCCC[C@H](NC(=O)c1nc(C(c2ccccc2)c2ccccc2)no1)C(=O)O | 10.1021/jm500956p | ||
127035774 | 143215 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 413 | 12 | 4 | 4 | 1.9 | NC(=O)NCCC[C@H](NC(=O)COCC(c1ccccc1)c1ccccc1)C(=O)O | 10.1016/j.bmcl.2015.10.038 | ||
CHEMBL3735614 | 143215 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 413 | 12 | 4 | 4 | 1.9 | NC(=O)NCCC[C@H](NC(=O)COCC(c1ccccc1)c1ccccc1)C(=O)O | 10.1016/j.bmcl.2015.10.038 | ||
3529 | 10290 | 9 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 412 | 12 | 4 | 4 | 1.5 | O=C(N[C@H](C(=O)O)CCCN=C(N)N)COCC(c1ccccc1)c1ccccc1 | 10.1021/acs.jmedchem.9b00927 | ||
5311120 | 10290 | 9 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 412 | 12 | 4 | 4 | 1.5 | O=C(N[C@H](C(=O)O)CCCN=C(N)N)COCC(c1ccccc1)c1ccccc1 | 10.1021/acs.jmedchem.9b00927 | ||
CHEMBL389348 | 10290 | 9 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 412 | 12 | 4 | 4 | 1.5 | O=C(N[C@H](C(=O)O)CCCN=C(N)N)COCC(c1ccccc1)c1ccccc1 | 10.1021/acs.jmedchem.9b00927 | ||
3529 | 10290 | 9 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 412 | 12 | 4 | 4 | 1.5 | O=C(N[C@H](C(=O)O)CCCN=C(N)N)COCC(c1ccccc1)c1ccccc1 | 10.1021/jm1003705 | ||
5311120 | 10290 | 9 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 412 | 12 | 4 | 4 | 1.5 | O=C(N[C@H](C(=O)O)CCCN=C(N)N)COCC(c1ccccc1)c1ccccc1 | 10.1021/jm1003705 | ||
CHEMBL389348 | 10290 | 9 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 412 | 12 | 4 | 4 | 1.5 | O=C(N[C@H](C(=O)O)CCCN=C(N)N)COCC(c1ccccc1)c1ccccc1 | 10.1021/jm1003705 | ||
155535683 | 178850 | 1 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 464 | 10 | 5 | 4 | 3.7 | Cc1cc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)sc1C(c1ccccc1)c1ccccc1 | 10.1021/acs.jmedchem.9b00927 | ||
CHEMBL4472196 | 178850 | 1 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 464 | 10 | 5 | 4 | 3.7 | Cc1cc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)sc1C(c1ccccc1)c1ccccc1 | 10.1021/acs.jmedchem.9b00927 | ||
155554899 | 181119 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 526 | 11 | 5 | 4 | 5.0 | N=C(N)NCCC[C@H](NC(=O)c1cc(-c2ccccc2)c(C(c2ccccc2)c2ccccc2)s1)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
CHEMBL4551058 | 181119 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 526 | 11 | 5 | 4 | 5.0 | N=C(N)NCCC[C@H](NC(=O)c1cc(-c2ccccc2)c(C(c2ccccc2)c2ccccc2)s1)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
CHEMBL2064018 | 215957 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/jm201609k | ||||
17753143 | 92715 | 4 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 434 | 10 | 5 | 4 | 2.9 | N=C(N)NCCC[C@H](NC(=O)c1ccc(C(c2ccccc2)c2ccccc2)o1)C(=O)O | 10.1021/jm500956p | ||
CHEMBL230034 | 92715 | 4 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 434 | 10 | 5 | 4 | 2.9 | N=C(N)NCCC[C@H](NC(=O)c1ccc(C(c2ccccc2)c2ccccc2)o1)C(=O)O | 10.1021/jm500956p | ||
117634981 | 121746 | 0 | None | - | 1 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 436 | 10 | 5 | 6 | 1.7 | N=C(N)NCCC[C@H](NC(=O)c1nnc(C(c2ccccc2)c2ccccc2)o1)C(=O)O | 10.1021/jm500956p | ||
CHEMBL3342682 | 121746 | 0 | None | - | 1 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 436 | 10 | 5 | 6 | 1.7 | N=C(N)NCCC[C@H](NC(=O)c1nnc(C(c2ccccc2)c2ccccc2)o1)C(=O)O | 10.1021/jm500956p | ||
155526496 | 177913 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 416 | 11 | 5 | 4 | 2.9 | CCC(Cc1ccccc1)c1ccc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)s1 | 10.1021/acs.jmedchem.9b00927 | ||
CHEMBL4458380 | 177913 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 416 | 11 | 5 | 4 | 2.9 | CCC(Cc1ccccc1)c1ccc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)s1 | 10.1021/acs.jmedchem.9b00927 | ||
17753143 | 92715 | 4 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 434 | 10 | 5 | 4 | 2.9 | N=C(N)NCCC[C@H](NC(=O)c1ccc(C(c2ccccc2)c2ccccc2)o1)C(=O)O | 10.1021/jm500956p | ||
CHEMBL230034 | 92715 | 4 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 434 | 10 | 5 | 4 | 2.9 | N=C(N)NCCC[C@H](NC(=O)c1ccc(C(c2ccccc2)c2ccccc2)o1)C(=O)O | 10.1021/jm500956p | ||
101886252 | 121747 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 511 | 11 | 5 | 5 | 4.0 | N=C(N)NCCC[C@H](NC(=O)c1oc(C(c2ccccc2)c2ccccc2)nc1-c1ccccc1)C(=O)O | 10.1021/jm500956p | ||
CHEMBL3342683 | 121747 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 511 | 11 | 5 | 5 | 4.0 | N=C(N)NCCC[C@H](NC(=O)c1oc(C(c2ccccc2)c2ccccc2)nc1-c1ccccc1)C(=O)O | 10.1021/jm500956p | ||
155516924 | 176929 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 538 | 12 | 4 | 7 | 3.8 | COC(=O)[C@H](CCCNC(=N)N)NC(=O)c1sc(C(c2ccc(OC)cc2)c2ccc(OC)cc2)cc1C | 10.1021/acs.jmedchem.9b00927 | ||
CHEMBL4444281 | 176929 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 538 | 12 | 4 | 7 | 3.8 | COC(=O)[C@H](CCCNC(=N)N)NC(=O)c1sc(C(c2ccc(OC)cc2)c2ccc(OC)cc2)cc1C | 10.1021/acs.jmedchem.9b00927 | ||
117634981 | 121746 | 0 | None | - | 1 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 436 | 10 | 5 | 6 | 1.7 | N=C(N)NCCC[C@H](NC(=O)c1nnc(C(c2ccccc2)c2ccccc2)o1)C(=O)O | 10.1021/jm500956p | ||
CHEMBL3342682 | 121746 | 0 | None | - | 1 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 436 | 10 | 5 | 6 | 1.7 | N=C(N)NCCC[C@H](NC(=O)c1nnc(C(c2ccccc2)c2ccccc2)o1)C(=O)O | 10.1021/jm500956p | ||
155526496 | 177913 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 416 | 11 | 5 | 4 | 2.9 | CCC(Cc1ccccc1)c1ccc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)s1 | 10.1021/acs.jmedchem.9b00927 | ||
CHEMBL4458380 | 177913 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 416 | 11 | 5 | 4 | 2.9 | CCC(Cc1ccccc1)c1ccc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)s1 | 10.1021/acs.jmedchem.9b00927 | ||
101886252 | 121747 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 511 | 11 | 5 | 5 | 4.0 | N=C(N)NCCC[C@H](NC(=O)c1oc(C(c2ccccc2)c2ccccc2)nc1-c1ccccc1)C(=O)O | 10.1021/jm500956p | ||
CHEMBL3342683 | 121747 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 511 | 11 | 5 | 5 | 4.0 | N=C(N)NCCC[C@H](NC(=O)c1oc(C(c2ccccc2)c2ccccc2)nc1-c1ccccc1)C(=O)O | 10.1021/jm500956p | ||
155516924 | 176929 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 538 | 12 | 4 | 7 | 3.8 | COC(=O)[C@H](CCCNC(=N)N)NC(=O)c1sc(C(c2ccc(OC)cc2)c2ccc(OC)cc2)cc1C | 10.1021/acs.jmedchem.9b00927 | ||
CHEMBL4444281 | 176929 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 538 | 12 | 4 | 7 | 3.8 | COC(=O)[C@H](CCCNC(=N)N)NC(=O)c1sc(C(c2ccc(OC)cc2)c2ccc(OC)cc2)cc1C | 10.1021/acs.jmedchem.9b00927 | ||
CHEMBL2064011 | 215950 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)[C@@H](C)O | 10.1021/jm201609k | ||||
155546129 | 180294 | 0 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 402 | 10 | 5 | 4 | 2.7 | CCC(c1ccccc1)c1ccc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)s1 | 10.1021/acs.jmedchem.9b00927 | ||
CHEMBL4530755 | 180294 | 0 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 402 | 10 | 5 | 4 | 2.7 | CCC(c1ccccc1)c1ccc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)s1 | 10.1021/acs.jmedchem.9b00927 | ||
CHEMBL1170644 | 215353 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CC1CCCCC1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)[C@@H](C)O | 10.1021/jm1003705 | ||||
155555271 | 181123 | 0 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 504 | 10 | 5 | 4 | 4.3 | N=C(N)NCCC[C@H](NC(=O)c1sc(C(c2ccccc2)c2ccccc2)c2c1CCCC2)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
CHEMBL4551118 | 181123 | 0 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 504 | 10 | 5 | 4 | 4.3 | N=C(N)NCCC[C@H](NC(=O)c1sc(C(c2ccccc2)c2ccccc2)c2c1CCCC2)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
155546129 | 180294 | 0 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 402 | 10 | 5 | 4 | 2.7 | CCC(c1ccccc1)c1ccc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)s1 | 10.1021/acs.jmedchem.9b00927 | ||
CHEMBL4530755 | 180294 | 0 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 402 | 10 | 5 | 4 | 2.7 | CCC(c1ccccc1)c1ccc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)s1 | 10.1021/acs.jmedchem.9b00927 | ||
155555271 | 181123 | 0 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 504 | 10 | 5 | 4 | 4.3 | N=C(N)NCCC[C@H](NC(=O)c1sc(C(c2ccccc2)c2ccccc2)c2c1CCCC2)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
CHEMBL4551118 | 181123 | 0 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 504 | 10 | 5 | 4 | 4.3 | N=C(N)NCCC[C@H](NC(=O)c1sc(C(c2ccccc2)c2ccccc2)c2c1CCCC2)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
CHEMBL2064019 | 215958 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/jm201609k | ||||
3529 | 10290 | 9 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 412 | 12 | 4 | 4 | 1.5 | O=C(N[C@H](C(=O)O)CCCN=C(N)N)COCC(c1ccccc1)c1ccccc1 | 10.1021/acs.jmedchem.7b00882 | ||
5311120 | 10290 | 9 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 412 | 12 | 4 | 4 | 1.5 | O=C(N[C@H](C(=O)O)CCCN=C(N)N)COCC(c1ccccc1)c1ccccc1 | 10.1021/acs.jmedchem.7b00882 | ||
CHEMBL389348 | 10290 | 9 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 412 | 12 | 4 | 4 | 1.5 | O=C(N[C@H](C(=O)O)CCCN=C(N)N)COCC(c1ccccc1)c1ccccc1 | 10.1021/acs.jmedchem.7b00882 | ||
101886251 | 121743 | 0 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 449 | 10 | 5 | 5 | 2.6 | Cc1nc(C(c2ccccc2)c2ccccc2)oc1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/jm500956p | ||
CHEMBL3342679 | 121743 | 0 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 449 | 10 | 5 | 5 | 2.6 | Cc1nc(C(c2ccccc2)c2ccccc2)oc1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/jm500956p | ||
155518058 | 177021 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 532 | 10 | 5 | 4 | 5.0 | Cc1cc(C(c2cccc(Cl)c2)c2cccc(Cl)c2)sc1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
CHEMBL4445758 | 177021 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 532 | 10 | 5 | 4 | 5.0 | Cc1cc(C(c2cccc(Cl)c2)c2cccc(Cl)c2)sc1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
155518058 | 177021 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 532 | 10 | 5 | 4 | 5.0 | Cc1cc(C(c2cccc(Cl)c2)c2cccc(Cl)c2)sc1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
CHEMBL4445758 | 177021 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 532 | 10 | 5 | 4 | 5.0 | Cc1cc(C(c2cccc(Cl)c2)c2cccc(Cl)c2)sc1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
155510486 | 181492 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 456 | 10 | 5 | 4 | 3.9 | N=C(N)NCCC[C@H](NC(=O)c1ccc(C(c2ccccc2)C2CCCCC2)s1)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
CHEMBL4559976 | 181492 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 456 | 10 | 5 | 4 | 3.9 | N=C(N)NCCC[C@H](NC(=O)c1ccc(C(c2ccccc2)C2CCCCC2)s1)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
155557328 | 181421 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 518 | 10 | 5 | 4 | 4.7 | N=C(N)NCCC[C@H](NC(=O)c1ccc(C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)s1)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
CHEMBL4558167 | 181421 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 518 | 10 | 5 | 4 | 4.7 | N=C(N)NCCC[C@H](NC(=O)c1ccc(C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)s1)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
155536326 | 178930 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 500 | 10 | 5 | 4 | 4.0 | Cc1cc(C(c2ccc(F)cc2)c2ccc(F)cc2)sc1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
CHEMBL4473192 | 178930 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 500 | 10 | 5 | 4 | 4.0 | Cc1cc(C(c2ccc(F)cc2)c2ccc(F)cc2)sc1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
155557328 | 181421 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 518 | 10 | 5 | 4 | 4.7 | N=C(N)NCCC[C@H](NC(=O)c1ccc(C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)s1)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
CHEMBL4558167 | 181421 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 518 | 10 | 5 | 4 | 4.7 | N=C(N)NCCC[C@H](NC(=O)c1ccc(C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)s1)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
44430514 | 157021 | 0 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 427 | 7 | 1 | 3 | 4.0 | O=C(NC1CCN(C(=O)CCc2cccnc2)CC1)C(c1ccccc1)c1ccccc1 | 10.1016/j.bmcl.2007.04.023 | ||
CHEMBL395233 | 157021 | 0 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 427 | 7 | 1 | 3 | 4.0 | O=C(NC1CCN(C(=O)CCc2cccnc2)CC1)C(c1ccccc1)c1ccccc1 | 10.1016/j.bmcl.2007.04.023 | ||
122392666 | 172616 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 463 | 9 | 4 | 5 | 3.0 | N=C(N)NCCC[C@@H](C(=O)O)N1Cc2nc(C(c3ccccc3)c3ccccc3)sc2C1=O | 10.1021/acs.jmedchem.7b00882 | ||
CHEMBL4248716 | 172616 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 463 | 9 | 4 | 5 | 3.0 | N=C(N)NCCC[C@@H](C(=O)O)N1Cc2nc(C(c3ccccc3)c3ccccc3)sc2C1=O | 10.1021/acs.jmedchem.7b00882 | ||
155536326 | 178930 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 500 | 10 | 5 | 4 | 4.0 | Cc1cc(C(c2ccc(F)cc2)c2ccc(F)cc2)sc1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
CHEMBL4473192 | 178930 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 500 | 10 | 5 | 4 | 4.0 | Cc1cc(C(c2ccc(F)cc2)c2ccc(F)cc2)sc1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
155557799 | 181474 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 451 | 10 | 5 | 5 | 2.8 | N=C(N)NCCC[C@H](NC(=O)c1ccc(C(c2ccccc2)c2ccccn2)s1)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
CHEMBL4559463 | 181474 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 451 | 10 | 5 | 5 | 2.8 | N=C(N)NCCC[C@H](NC(=O)c1ccc(C(c2ccccc2)c2ccccn2)s1)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
101886253 | 121742 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 411 | 12 | 6 | 4 | 1.2 | N=C(N)NCCC[C@H](NC(=O)CNCC(c1ccccc1)c1ccccc1)C(=O)O | 10.1021/jm500956p | ||
CHEMBL3342678 | 121742 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 411 | 12 | 6 | 4 | 1.2 | N=C(N)NCCC[C@H](NC(=O)CNCC(c1ccccc1)c1ccccc1)C(=O)O | 10.1021/jm500956p | ||
101886251 | 121743 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 449 | 10 | 5 | 5 | 2.6 | Cc1nc(C(c2ccccc2)c2ccccc2)oc1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/jm500956p | ||
CHEMBL3342679 | 121743 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 449 | 10 | 5 | 5 | 2.6 | Cc1nc(C(c2ccccc2)c2ccccc2)oc1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/jm500956p | ||
3529 | 10290 | 9 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 412 | 12 | 4 | 4 | 1.5 | O=C(N[C@H](C(=O)O)CCCN=C(N)N)COCC(c1ccccc1)c1ccccc1 | 10.1021/acs.jmedchem.9b00927 | ||
5311120 | 10290 | 9 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 412 | 12 | 4 | 4 | 1.5 | O=C(N[C@H](C(=O)O)CCCN=C(N)N)COCC(c1ccccc1)c1ccccc1 | 10.1021/acs.jmedchem.9b00927 | ||
CHEMBL389348 | 10290 | 9 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 412 | 12 | 4 | 4 | 1.5 | O=C(N[C@H](C(=O)O)CCCN=C(N)N)COCC(c1ccccc1)c1ccccc1 | 10.1021/acs.jmedchem.9b00927 | ||
155563876 | 182050 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 414 | 9 | 5 | 4 | 3.0 | CC(C)=C(c1ccccc1)c1ccc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)s1 | 10.1021/acs.jmedchem.9b00927 | ||
CHEMBL4572633 | 182050 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 414 | 9 | 5 | 4 | 3.0 | CC(C)=C(c1ccccc1)c1ccc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)s1 | 10.1021/acs.jmedchem.9b00927 | ||
101886253 | 121742 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 411 | 12 | 6 | 4 | 1.2 | N=C(N)NCCC[C@H](NC(=O)CNCC(c1ccccc1)c1ccccc1)C(=O)O | 10.1021/jm500956p | ||
CHEMBL3342678 | 121742 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 411 | 12 | 6 | 4 | 1.2 | N=C(N)NCCC[C@H](NC(=O)CNCC(c1ccccc1)c1ccccc1)C(=O)O | 10.1021/jm500956p | ||
155510486 | 181492 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 456 | 10 | 5 | 4 | 3.9 | N=C(N)NCCC[C@H](NC(=O)c1ccc(C(c2ccccc2)C2CCCCC2)s1)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
CHEMBL4559976 | 181492 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 456 | 10 | 5 | 4 | 3.9 | N=C(N)NCCC[C@H](NC(=O)c1ccc(C(c2ccccc2)C2CCCCC2)s1)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
CHEMBL2064017 | 215956 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)[C@@H](C)O | 10.1021/jm201609k | ||||
155557799 | 181474 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 451 | 10 | 5 | 5 | 2.8 | N=C(N)NCCC[C@H](NC(=O)c1ccc(C(c2ccccc2)c2ccccn2)s1)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
CHEMBL4559463 | 181474 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 451 | 10 | 5 | 5 | 2.8 | N=C(N)NCCC[C@H](NC(=O)c1ccc(C(c2ccccc2)c2ccccn2)s1)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
155563876 | 182050 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 414 | 9 | 5 | 4 | 3.0 | CC(C)=C(c1ccccc1)c1ccc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)s1 | 10.1021/acs.jmedchem.9b00927 | ||
CHEMBL4572633 | 182050 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 414 | 9 | 5 | 4 | 3.0 | CC(C)=C(c1ccccc1)c1ccc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)s1 | 10.1021/acs.jmedchem.9b00927 | ||
CHEMBL2064014 | 215953 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)[C@@H](C)O)[C@@H](C)O | 10.1021/jm201609k | ||||
CHEMBL2063898 | 215949 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)[C@@H](C)O | 10.1021/jm201609k | ||||
155569071 | 182938 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 528 | 10 | 5 | 4 | 4.1 | N=C(N)NCCC[C@H](NC(=O)c1sc(C(c2ccccc2)c2ccccc2)cc1Br)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
CHEMBL4592883 | 182938 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 528 | 10 | 5 | 4 | 4.1 | N=C(N)NCCC[C@H](NC(=O)c1sc(C(c2ccccc2)c2ccccc2)cc1Br)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
155569071 | 182938 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 528 | 10 | 5 | 4 | 4.1 | N=C(N)NCCC[C@H](NC(=O)c1sc(C(c2ccccc2)c2ccccc2)cc1Br)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
CHEMBL4592883 | 182938 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 528 | 10 | 5 | 4 | 4.1 | N=C(N)NCCC[C@H](NC(=O)c1sc(C(c2ccccc2)c2ccccc2)cc1Br)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
118716617 | 121741 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 410 | 12 | 5 | 3 | 2.8 | N=C(N)NCCC[C@H](NC(=O)CCCC(c1ccccc1)c1ccccc1)C(=O)O | 10.1021/jm500956p | ||
CHEMBL3342677 | 121741 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 410 | 12 | 5 | 3 | 2.8 | N=C(N)NCCC[C@H](NC(=O)CCCC(c1ccccc1)c1ccccc1)C(=O)O | 10.1021/jm500956p | ||
155527368 | 178019 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 518 | 10 | 5 | 4 | 4.7 | N=C(N)NCCC[C@H](NC(=O)c1ccc(C(c2cccc(Cl)c2)c2cccc(Cl)c2)s1)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
CHEMBL4459830 | 178019 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 518 | 10 | 5 | 4 | 4.7 | N=C(N)NCCC[C@H](NC(=O)c1ccc(C(c2cccc(Cl)c2)c2cccc(Cl)c2)s1)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
155527368 | 178019 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 518 | 10 | 5 | 4 | 4.7 | N=C(N)NCCC[C@H](NC(=O)c1ccc(C(c2cccc(Cl)c2)c2cccc(Cl)c2)s1)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
CHEMBL4459830 | 178019 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 518 | 10 | 5 | 4 | 4.7 | N=C(N)NCCC[C@H](NC(=O)c1ccc(C(c2cccc(Cl)c2)c2cccc(Cl)c2)s1)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
155534696 | 178758 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 464 | 10 | 5 | 4 | 3.7 | Cc1cc(C(c2ccccc2)c2ccccc2)sc1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
CHEMBL4470864 | 178758 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 464 | 10 | 5 | 4 | 3.7 | Cc1cc(C(c2ccccc2)c2ccccc2)sc1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
89570464 | 176598 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 451 | 10 | 5 | 5 | 2.8 | N=C(N)NCCC[C@H](NC(=O)c1cnc(C(c2ccccc2)c2ccccc2)s1)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
CHEMBL4439578 | 176598 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 451 | 10 | 5 | 5 | 2.8 | N=C(N)NCCC[C@H](NC(=O)c1cnc(C(c2ccccc2)c2ccccc2)s1)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
155535658 | 178877 | 0 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 510 | 12 | 5 | 6 | 3.4 | COc1ccc(C(c2ccc(OC)cc2)c2ccc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)s2)cc1 | 10.1021/acs.jmedchem.9b00927 | ||
CHEMBL4472490 | 178877 | 0 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 510 | 12 | 5 | 6 | 3.4 | COc1ccc(C(c2ccc(OC)cc2)c2ccc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)s2)cc1 | 10.1021/acs.jmedchem.9b00927 | ||
CHEMBL2064020 | 215959 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/jm201609k | ||||
89570464 | 176598 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 451 | 10 | 5 | 5 | 2.8 | N=C(N)NCCC[C@H](NC(=O)c1cnc(C(c2ccccc2)c2ccccc2)s1)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
CHEMBL4439578 | 176598 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 451 | 10 | 5 | 5 | 2.8 | N=C(N)NCCC[C@H](NC(=O)c1cnc(C(c2ccccc2)c2ccccc2)s1)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
44430510 | 165897 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 509 | 5 | 1 | 4 | 5.4 | O=C(NC1CCN(C(=O)CCc2cccnc2)CC1)C1c2cc(Cl)ccc2Oc2ccc(Cl)cc21 | 10.1016/j.bmcl.2007.04.023 | ||
CHEMBL409773 | 165897 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 509 | 5 | 1 | 4 | 5.4 | O=C(NC1CCN(C(=O)CCc2cccnc2)CC1)C1c2cc(Cl)ccc2Oc2ccc(Cl)cc21 | 10.1016/j.bmcl.2007.04.023 | ||
CHEMBL1170028 | 215320 | 0 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/jm1003705 | ||||
118716617 | 121741 | 0 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 410 | 12 | 5 | 3 | 2.8 | N=C(N)NCCC[C@H](NC(=O)CCCC(c1ccccc1)c1ccccc1)C(=O)O | 10.1021/jm500956p | ||
CHEMBL3342677 | 121741 | 0 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 410 | 12 | 5 | 3 | 2.8 | N=C(N)NCCC[C@H](NC(=O)CCCC(c1ccccc1)c1ccccc1)C(=O)O | 10.1021/jm500956p | ||
155535658 | 178877 | 0 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 510 | 12 | 5 | 6 | 3.4 | COc1ccc(C(c2ccc(OC)cc2)c2ccc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)s2)cc1 | 10.1021/acs.jmedchem.9b00927 | ||
CHEMBL4472490 | 178877 | 0 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 510 | 12 | 5 | 6 | 3.4 | COc1ccc(C(c2ccc(OC)cc2)c2ccc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)s2)cc1 | 10.1021/acs.jmedchem.9b00927 | ||
155534696 | 178758 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 464 | 10 | 5 | 4 | 3.7 | Cc1cc(C(c2ccccc2)c2ccccc2)sc1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
CHEMBL4470864 | 178758 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 464 | 10 | 5 | 4 | 3.7 | Cc1cc(C(c2ccccc2)c2ccccc2)sc1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
CHEMBL2064015 | 215954 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)[C@@H](C)O)[C@@H](C)O | 10.1021/jm201609k | ||||
25156014 | 182228 | 2 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 450 | 10 | 5 | 4 | 3.4 | N=C(N)NCCC[C@H](NC(=O)c1ccc(C(c2ccccc2)c2ccccc2)s1)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
CHEMBL4576800 | 182228 | 2 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 450 | 10 | 5 | 4 | 3.4 | N=C(N)NCCC[C@H](NC(=O)c1ccc(C(c2ccccc2)c2ccccc2)s1)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
155534229 | 178717 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 496 | 10 | 7 | 6 | 3.1 | Cc1cc(C(c2ccc(O)cc2)c2ccc(O)cc2)sc1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
CHEMBL4470384 | 178717 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 496 | 10 | 7 | 6 | 3.1 | Cc1cc(C(c2ccc(O)cc2)c2ccc(O)cc2)sc1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
8384 | 7897 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 428 | 12 | 5 | 4 | 2.4 | NC(=N)NCCC[C@@H](C(=O)O)NC(=O)CSCC(c1ccccc1)c1ccccc1 | 10.1021/jm500956p | ||
91827355 | 7897 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 428 | 12 | 5 | 4 | 2.4 | NC(=N)NCCC[C@@H](C(=O)O)NC(=O)CSCC(c1ccccc1)c1ccccc1 | 10.1021/jm500956p | ||
CHEMBL3342676 | 7897 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 428 | 12 | 5 | 4 | 2.4 | NC(=N)NCCC[C@@H](C(=O)O)NC(=O)CSCC(c1ccccc1)c1ccccc1 | 10.1021/jm500956p | ||
155534229 | 178717 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 496 | 10 | 7 | 6 | 3.1 | Cc1cc(C(c2ccc(O)cc2)c2ccc(O)cc2)sc1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
CHEMBL4470384 | 178717 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 496 | 10 | 7 | 6 | 3.1 | Cc1cc(C(c2ccc(O)cc2)c2ccc(O)cc2)sc1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
25156014 | 182228 | 2 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 450 | 10 | 5 | 4 | 3.4 | N=C(N)NCCC[C@H](NC(=O)c1ccc(C(c2ccccc2)c2ccccc2)s1)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
CHEMBL4576800 | 182228 | 2 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 450 | 10 | 5 | 4 | 3.4 | N=C(N)NCCC[C@H](NC(=O)c1ccc(C(c2ccccc2)c2ccccc2)s1)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
CHEMBL2064018 | 215957 | 0 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/jm201609k | ||||
CHEMBL2064016 | 215955 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)[C@@H](C)O | 10.1021/jm201609k | ||||
155525092 | 177719 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 500 | 10 | 5 | 4 | 4.5 | N=C(N)NCCC[C@H](NC(=O)c1ccc(C(c2ccccc2)c2ccc3ccccc3c2)s1)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
CHEMBL4455385 | 177719 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 500 | 10 | 5 | 4 | 4.5 | N=C(N)NCCC[C@H](NC(=O)c1ccc(C(c2ccccc2)c2ccc3ccccc3c2)s1)C(=O)O | 10.1021/acs.jmedchem.9b00927 | ||
127035774 | 143215 | 0 | None | - | 1 | Human | 6.9 | pKd | = | 6.9 | Functional | ChEMBL | 413 | 12 | 4 | 4 | 1.9 | NC(=O)NCCC[C@H](NC(=O)COCC(c1ccccc1)c1ccccc1)C(=O)O | 10.1016/j.bmcl.2015.10.038 | ||
CHEMBL3735614 | 143215 | 0 | None | - | 1 | Human | 6.9 | pKd | = | 6.9 | Functional | ChEMBL | 413 | 12 | 4 | 4 | 1.9 | NC(=O)NCCC[C@H](NC(=O)COCC(c1ccccc1)c1ccccc1)C(=O)O | 10.1016/j.bmcl.2015.10.038 | ||
127035774 | 143215 | 0 | None | - | 1 | Human | 6.8 | pKd | = | 6.8 | Functional | ChEMBL | 413 | 12 | 4 | 4 | 1.9 | NC(=O)NCCC[C@H](NC(=O)COCC(c1ccccc1)c1ccccc1)C(=O)O | 10.1016/j.bmcl.2015.10.038 | ||
CHEMBL3735614 | 143215 | 0 | None | - | 1 | Human | 6.8 | pKd | = | 6.8 | Functional | ChEMBL | 413 | 12 | 4 | 4 | 1.9 | NC(=O)NCCC[C@H](NC(=O)COCC(c1ccccc1)c1ccccc1)C(=O)O | 10.1016/j.bmcl.2015.10.038 | ||
3640 | 7556 | 0 | None | - | 1 | Human | 9.6 | pEC50 | = | 9.6 | Functional | Guide to Pharmacology | None | None | None | None | 9476119 | ||||
3915 | 8307 | 11 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | Guide to Pharmacology | None | None | None | None | 20527893 | ||||
49799079 | 8307 | 11 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | Guide to Pharmacology | None | None | None | None | 20527893 | ||||
5760 | 8307 | 11 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | Guide to Pharmacology | None | None | None | None | 20527893 | ||||
91933514 | 8307 | 11 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | Guide to Pharmacology | None | None | None | None | 20527893 | ||||
CHEMBL1170024 | 8307 | 11 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | Guide to Pharmacology | None | None | None | None | 20527893 | ||||
8380 | 7055 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Functional | Guide to Pharmacology | None | None | None | None | 25446428 | ||||
49799093 | 8433 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | Guide to Pharmacology | None | None | None | None | 20527893 | ||||
5761 | 8433 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | Guide to Pharmacology | None | None | None | None | 20527893 | ||||
CHEMBL1172879 | 8433 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | Guide to Pharmacology | None | None | None | None | 20527893 | ||||
134813896 | 10431 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | Guide to Pharmacology | None | None | None | None | 22500977 | ||||
60201789 | 10431 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | Guide to Pharmacology | None | None | None | None | 22500977 | ||||
8379 | 10431 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | Guide to Pharmacology | None | None | None | None | 22500977 | ||||
5776 | 10901 | 0 | None | 8 | 2 | Human | 6.7 | pEC50 | = | 6.7 | Functional | Guide to Pharmacology | None | None | None | None | 20527893 | ||||
3640 | 7556 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | Guide to Pharmacology | None | None | None | None | 20527893 | ||||
8381 | 7816 | 3 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | Guide to Pharmacology | 448 | 10 | 6 | 4 | 2.3 | O=C(c1nc([nH]c1C)C(c1ccccc1)c1ccccc1)N[C@H](C(=O)O)CCCNC(=N)N | 25259874 | ||
91827354 | 7816 | 3 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | Guide to Pharmacology | 448 | 10 | 6 | 4 | 2.3 | O=C(c1nc([nH]c1C)C(c1ccccc1)c1ccccc1)N[C@H](C(=O)O)CCCNC(=N)N | 25259874 | ||
CHEMBL3342689 | 7816 | 3 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | Guide to Pharmacology | 448 | 10 | 6 | 4 | 2.3 | O=C(c1nc([nH]c1C)C(c1ccccc1)c1ccccc1)N[C@H](C(=O)O)CCCNC(=N)N | 25259874 | ||
71566654 | 7792 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | Guide to Pharmacology | 497 | 12 | 6 | 6 | 1.9 | CC(C[C@@H](c1occ(n1)C(=O)N[C@H](C(=O)O)CCCN=C(N)N)NC(=O)c1c[nH]c2c1cccc2)C | 24257095 | ||
9449 | 7792 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | Guide to Pharmacology | 497 | 12 | 6 | 6 | 1.9 | CC(C[C@@H](c1occ(n1)C(=O)N[C@H](C(=O)O)CCCN=C(N)N)NC(=O)c1c[nH]c2c1cccc2)C | 24257095 | ||
CHEMBL3736108 | 7792 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | Guide to Pharmacology | 497 | 12 | 6 | 6 | 1.9 | CC(C[C@@H](c1occ(n1)C(=O)N[C@H](C(=O)O)CCCN=C(N)N)NC(=O)c1c[nH]c2c1cccc2)C | 24257095 | ||
3915 | 8307 | 11 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | Guide to Pharmacology | None | None | None | None | 2015217 | ||||
3915 | 8307 | 11 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | Guide to Pharmacology | None | None | None | None | 20527893 | ||||
3915 | 8307 | 11 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | Guide to Pharmacology | None | None | None | None | 9476119 | ||||
49799079 | 8307 | 11 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | Guide to Pharmacology | None | None | None | None | 2015217 | ||||
49799079 | 8307 | 11 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | Guide to Pharmacology | None | None | None | None | 20527893 | ||||
49799079 | 8307 | 11 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | Guide to Pharmacology | None | None | None | None | 9476119 | ||||
5760 | 8307 | 11 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | Guide to Pharmacology | None | None | None | None | 2015217 | ||||
5760 | 8307 | 11 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | Guide to Pharmacology | None | None | None | None | 20527893 | ||||
5760 | 8307 | 11 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | Guide to Pharmacology | None | None | None | None | 9476119 | ||||
91933514 | 8307 | 11 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | Guide to Pharmacology | None | None | None | None | 2015217 | ||||
91933514 | 8307 | 11 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | Guide to Pharmacology | None | None | None | None | 20527893 | ||||
91933514 | 8307 | 11 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | Guide to Pharmacology | None | None | None | None | 9476119 | ||||
CHEMBL1170024 | 8307 | 11 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | Guide to Pharmacology | None | None | None | None | 2015217 | ||||
CHEMBL1170024 | 8307 | 11 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | Guide to Pharmacology | None | None | None | None | 20527893 | ||||
CHEMBL1170024 | 8307 | 11 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | Guide to Pharmacology | None | None | None | None | 9476119 | ||||
10595 | 8934 | 21 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Functional | Guide to Pharmacology | 532 | 10 | 5 | 4 | 5.0 | O=C(c1sc(cc1C)C(c1ccc(cc1)Cl)c1ccc(cc1)Cl)N[C@H](C(=O)O)CCCNC(=N)N | 31910011 | ||
145996525 | 8934 | 21 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Functional | Guide to Pharmacology | 532 | 10 | 5 | 4 | 5.0 | O=C(c1sc(cc1C)C(c1ccc(cc1)Cl)c1ccc(cc1)Cl)N[C@H](C(=O)O)CCCNC(=N)N | 31910011 | ||
CHEMBL4459627 | 8934 | 21 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Functional | Guide to Pharmacology | 532 | 10 | 5 | 4 | 5.0 | O=C(c1sc(cc1C)C(c1ccc(cc1)Cl)c1ccc(cc1)Cl)N[C@H](C(=O)O)CCCNC(=N)N | 31910011 | ||
10224 | 7592 | 0 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | Guide to Pharmacology | None | None | None | None | 26297549 | ||||
10224 | 7592 | 0 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | Guide to Pharmacology | None | None | None | None | 9145417 | ||||
25254550 | 7592 | 0 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | Guide to Pharmacology | None | None | None | None | 26297549 | ||||
25254550 | 7592 | 0 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | Guide to Pharmacology | None | None | None | None | 9145417 | ||||
8384 | 7897 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | Guide to Pharmacology | 428 | 12 | 5 | 4 | 2.4 | NC(=N)NCCC[C@@H](C(=O)O)NC(=O)CSCC(c1ccccc1)c1ccccc1 | 25259874 | ||
91827355 | 7897 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | Guide to Pharmacology | 428 | 12 | 5 | 4 | 2.4 | NC(=N)NCCC[C@@H](C(=O)O)NC(=O)CSCC(c1ccccc1)c1ccccc1 | 25259874 | ||
CHEMBL3342676 | 7897 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | Guide to Pharmacology | 428 | 12 | 5 | 4 | 2.4 | NC(=N)NCCC[C@@H](C(=O)O)NC(=O)CSCC(c1ccccc1)c1ccccc1 | 25259874 | ||
5777 | 8435 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | Guide to Pharmacology | None | None | None | None | 20527893 | ||||
3529 | 10290 | 9 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | Guide to Pharmacology | 412 | 12 | 4 | 4 | 1.5 | O=C(N[C@H](C(=O)O)CCCN=C(N)N)COCC(c1ccccc1)c1ccccc1 | 11342658 | ||
3529 | 10290 | 9 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | Guide to Pharmacology | 412 | 12 | 4 | 4 | 1.5 | O=C(N[C@H](C(=O)O)CCCN=C(N)N)COCC(c1ccccc1)c1ccccc1 | 33551801 | ||
5311120 | 10290 | 9 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | Guide to Pharmacology | 412 | 12 | 4 | 4 | 1.5 | O=C(N[C@H](C(=O)O)CCCN=C(N)N)COCC(c1ccccc1)c1ccccc1 | 11342658 | ||
5311120 | 10290 | 9 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | Guide to Pharmacology | 412 | 12 | 4 | 4 | 1.5 | O=C(N[C@H](C(=O)O)CCCN=C(N)N)COCC(c1ccccc1)c1ccccc1 | 33551801 | ||
CHEMBL389348 | 10290 | 9 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | Guide to Pharmacology | 412 | 12 | 4 | 4 | 1.5 | O=C(N[C@H](C(=O)O)CCCN=C(N)N)COCC(c1ccccc1)c1ccccc1 | 11342658 | ||
CHEMBL389348 | 10290 | 9 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | Guide to Pharmacology | 412 | 12 | 4 | 4 | 1.5 | O=C(N[C@H](C(=O)O)CCCN=C(N)N)COCC(c1ccccc1)c1ccccc1 | 33551801 | ||
3915 | 8307 | 11 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | Guide to Pharmacology | None | None | None | None | 20527893 | ||||
49799079 | 8307 | 11 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | Guide to Pharmacology | None | None | None | None | 20527893 | ||||
5760 | 8307 | 11 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | Guide to Pharmacology | None | None | None | None | 20527893 | ||||
91933514 | 8307 | 11 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | Guide to Pharmacology | None | None | None | None | 20527893 | ||||
CHEMBL1170024 | 8307 | 11 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | Guide to Pharmacology | None | None | None | None | 20527893 |
Ligands (move mouse cursor over ligand name to see structure) | Receptor | Assay information | Chemical information | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Similar- ity |
Common name |
GPCRdb ID |
#Vendors |
Reference ligand |
Fold selectivity |
# Tested GPCRs |
Species |
p-value (-log) |
Activity Type |
Activity Relation |
Activity Value |
Assay Type |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
CHEMBL1170042 | 215327 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | None | None | None | None | 10.1021/jm1003705 | |||||
155534696 | 178758 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 464 | 10 | 5 | 4 | 3.7 | Cc1cc(C(c2ccccc2)c2ccccc2)sc1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/acs.jmedchem.9b00927 | |||
CHEMBL4470864 | 178758 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 464 | 10 | 5 | 4 | 3.7 | Cc1cc(C(c2ccccc2)c2ccccc2)sc1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/acs.jmedchem.9b00927 | |||
3915 | 8307 | 11 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | None | None | None | None | 10.1021/jm1003705 | |||||
49799079 | 8307 | 11 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | None | None | None | None | 10.1021/jm1003705 | |||||
5760 | 8307 | 11 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | None | None | None | None | 10.1021/jm1003705 | |||||
91933514 | 8307 | 11 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | None | None | None | None | 10.1021/jm1003705 | |||||
CHEMBL1170024 | 8307 | 11 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | None | None | None | None | 10.1021/jm1003705 | |||||
8381 | 7816 | 3 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 448 | 10 | 6 | 4 | 2.3 | O=C(c1nc([nH]c1C)C(c1ccccc1)c1ccccc1)N[C@H](C(=O)O)CCCNC(=N)N | 10.1021/jm500956p | |||
91827354 | 7816 | 3 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 448 | 10 | 6 | 4 | 2.3 | O=C(c1nc([nH]c1C)C(c1ccccc1)c1ccccc1)N[C@H](C(=O)O)CCCNC(=N)N | 10.1021/jm500956p | |||
CHEMBL3342689 | 7816 | 3 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 448 | 10 | 6 | 4 | 2.3 | O=C(c1nc([nH]c1C)C(c1ccccc1)c1ccccc1)N[C@H](C(=O)O)CCCNC(=N)N | 10.1021/jm500956p | |||
3529 | 10290 | 9 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 412 | 12 | 4 | 4 | 1.5 | O=C(N[C@H](C(=O)O)CCCN=C(N)N)COCC(c1ccccc1)c1ccccc1 | 10.1021/jm500956p | |||
5311120 | 10290 | 9 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 412 | 12 | 4 | 4 | 1.5 | O=C(N[C@H](C(=O)O)CCCN=C(N)N)COCC(c1ccccc1)c1ccccc1 | 10.1021/jm500956p | |||
CHEMBL389348 | 10290 | 9 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 412 | 12 | 4 | 4 | 1.5 | O=C(N[C@H](C(=O)O)CCCN=C(N)N)COCC(c1ccccc1)c1ccccc1 | 10.1021/jm500956p | |||
89570442 | 121750 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 449 | 10 | 5 | 5 | 2.6 | Cc1oc(C(c2ccccc2)c2ccccc2)nc1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/jm500956p | |||
CHEMBL3342686 | 121750 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 449 | 10 | 5 | 5 | 2.6 | Cc1oc(C(c2ccccc2)c2ccccc2)nc1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/jm500956p | |||
127035774 | 143215 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 413 | 12 | 4 | 4 | 1.9 | NC(=O)NCCC[C@H](NC(=O)COCC(c1ccccc1)c1ccccc1)C(=O)O | 10.1016/j.bmcl.2015.10.038 | |||
CHEMBL3735614 | 143215 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 413 | 12 | 4 | 4 | 1.9 | NC(=O)NCCC[C@H](NC(=O)COCC(c1ccccc1)c1ccccc1)C(=O)O | 10.1016/j.bmcl.2015.10.038 | |||
118716617 | 121741 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 410 | 12 | 5 | 3 | 2.8 | N=C(N)NCCC[C@H](NC(=O)CCCC(c1ccccc1)c1ccccc1)C(=O)O | 10.1021/jm500956p | |||
CHEMBL3342677 | 121741 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 410 | 12 | 5 | 3 | 2.8 | N=C(N)NCCC[C@H](NC(=O)CCCC(c1ccccc1)c1ccccc1)C(=O)O | 10.1021/jm500956p | |||
101886251 | 121743 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 449 | 10 | 5 | 5 | 2.6 | Cc1nc(C(c2ccccc2)c2ccccc2)oc1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/jm500956p | |||
CHEMBL3342679 | 121743 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 449 | 10 | 5 | 5 | 2.6 | Cc1nc(C(c2ccccc2)c2ccccc2)oc1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/jm500956p | |||
101886252 | 121747 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 511 | 11 | 5 | 5 | 4.0 | N=C(N)NCCC[C@H](NC(=O)c1oc(C(c2ccccc2)c2ccccc2)nc1-c1ccccc1)C(=O)O | 10.1021/jm500956p | |||
CHEMBL3342683 | 121747 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 511 | 11 | 5 | 5 | 4.0 | N=C(N)NCCC[C@H](NC(=O)c1oc(C(c2ccccc2)c2ccccc2)nc1-c1ccccc1)C(=O)O | 10.1021/jm500956p | |||
44430549 | 158045 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 487 | 7 | 1 | 3 | 4.9 | O=C(NC1CCN(C(=O)CCc2cccnc2)CC1)C(c1cc(F)c(F)c(F)c1)C1CCCCC1 | 10.1016/j.bmcl.2007.04.023 | |||
CHEMBL396030 | 158045 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 487 | 7 | 1 | 3 | 4.9 | O=C(NC1CCN(C(=O)CCc2cccnc2)CC1)C(c1cc(F)c(F)c(F)c1)C1CCCCC1 | 10.1016/j.bmcl.2007.04.023 | |||
117634981 | 121746 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 436 | 10 | 5 | 6 | 1.7 | N=C(N)NCCC[C@H](NC(=O)c1nnc(C(c2ccccc2)c2ccccc2)o1)C(=O)O | 10.1021/jm500956p | |||
CHEMBL3342682 | 121746 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 436 | 10 | 5 | 6 | 1.7 | N=C(N)NCCC[C@H](NC(=O)c1nnc(C(c2ccccc2)c2ccccc2)o1)C(=O)O | 10.1021/jm500956p | |||
44430552 | 94780 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 439 | 7 | 1 | 3 | 4.9 | O=C(NC1CCN(C(=O)CCc2cccnc2)CC1)C(C1CCCCC1)C1CCCCC1 | 10.1016/j.bmcl.2007.04.023 | |||
CHEMBL234306 | 94780 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 439 | 7 | 1 | 3 | 4.9 | O=C(NC1CCN(C(=O)CCc2cccnc2)CC1)C(C1CCCCC1)C1CCCCC1 | 10.1016/j.bmcl.2007.04.023 | |||
44430556 | 94826 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 431 | 6 | 1 | 3 | 4.6 | O=C(NC1CCN(C(=O)/C=C/c2cccnc2)CC1)C(c1ccccc1)C1CCCCC1 | 10.1016/j.bmcl.2007.04.023 | |||
CHEMBL234523 | 94826 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 431 | 6 | 1 | 3 | 4.6 | O=C(NC1CCN(C(=O)/C=C/c2cccnc2)CC1)C(c1ccccc1)C1CCCCC1 | 10.1016/j.bmcl.2007.04.023 | |||
44430526 | 151013 | 1 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 461 | 7 | 1 | 3 | 5.1 | CC1(C)CCC(C(C(=O)NC2CCN(C(=O)CCc3cccnc3)CC2)c2ccccc2)CC1 | 10.1016/j.bmcl.2007.04.023 | |||
CHEMBL390464 | 151013 | 1 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 461 | 7 | 1 | 3 | 5.1 | CC1(C)CCC(C(C(=O)NC2CCN(C(=O)CCc3cccnc3)CC2)c2ccccc2)CC1 | 10.1016/j.bmcl.2007.04.023 | |||
44430559 | 94945 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 454 | 6 | 1 | 2 | 5.0 | O=C(NC1CCN(C(=O)Cc2cccc(F)c2F)CC1)C(c1ccccc1)C1CCCCC1 | 10.1016/j.bmcl.2007.04.023 | |||
CHEMBL234730 | 94945 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 454 | 6 | 1 | 2 | 5.0 | O=C(NC1CCN(C(=O)Cc2cccc(F)c2F)CC1)C(c1ccccc1)C1CCCCC1 | 10.1016/j.bmcl.2007.04.023 | |||
44426471 | 92478 | 0 | None | - | 0 | Human | 4.0 | pIC50 | = | 4 | Binding | ChEMBL | 388 | 8 | 5 | 3 | 2.5 | N=C(N)NCCC[C@@H](NC(=O)c1ccc(-c2cccc(Cl)c2)cc1)C(=O)O | 10.1016/j.bmcl.2007.04.022 | |||
CHEMBL228846 | 92478 | 0 | None | - | 0 | Human | 4.0 | pIC50 | = | 4 | Binding | ChEMBL | 388 | 8 | 5 | 3 | 2.5 | N=C(N)NCCC[C@@H](NC(=O)c1ccc(-c2cccc(Cl)c2)cc1)C(=O)O | 10.1016/j.bmcl.2007.04.022 | |||
117634952 | 143312 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 490 | 13 | 6 | 6 | 1.7 | CC(C)C[C@H](NC(=O)Cc1ccc(F)cc1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
CHEMBL3736505 | 143312 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 490 | 13 | 6 | 6 | 1.7 | CC(C)C[C@H](NC(=O)Cc1ccc(F)cc1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
117634952 | 143312 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 490 | 13 | 6 | 6 | 1.7 | CC(C)C[C@H](NC(=O)Cc1ccc(F)cc1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
CHEMBL3736505 | 143312 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 490 | 13 | 6 | 6 | 1.7 | CC(C)C[C@H](NC(=O)Cc1ccc(F)cc1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
127034743 | 143311 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 542 | 15 | 6 | 6 | 3.3 | CC(C)Cc1ccc(C(C)C(=O)N[C@@H](CC(C)C)c2nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co2)cc1 | 10.1016/j.bmcl.2015.10.038 | |||
CHEMBL3736489 | 143311 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 542 | 15 | 6 | 6 | 3.3 | CC(C)Cc1ccc(C(C)C(=O)N[C@@H](CC(C)C)c2nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co2)cc1 | 10.1016/j.bmcl.2015.10.038 | |||
127034743 | 143311 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 542 | 15 | 6 | 6 | 3.3 | CC(C)Cc1ccc(C(C)C(=O)N[C@@H](CC(C)C)c2nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co2)cc1 | 10.1016/j.bmcl.2015.10.038 | |||
CHEMBL3736489 | 143311 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 542 | 15 | 6 | 6 | 3.3 | CC(C)Cc1ccc(C(C)C(=O)N[C@@H](CC(C)C)c2nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co2)cc1 | 10.1016/j.bmcl.2015.10.038 | |||
89570392 | 143255 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 512 | 12 | 6 | 6 | 2.4 | CC[C@H](C)[C@H](NC(=O)C1CCCc2ccccc21)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
CHEMBL3736020 | 143255 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 512 | 12 | 6 | 6 | 2.4 | CC[C@H](C)[C@H](NC(=O)C1CCCc2ccccc21)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
89570392 | 143255 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 512 | 12 | 6 | 6 | 2.4 | CC[C@H](C)[C@H](NC(=O)C1CCCc2ccccc21)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
CHEMBL3736020 | 143255 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 512 | 12 | 6 | 6 | 2.4 | CC[C@H](C)[C@H](NC(=O)C1CCCc2ccccc21)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
89570442 | 121750 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 449 | 10 | 5 | 5 | 2.6 | Cc1oc(C(c2ccccc2)c2ccccc2)nc1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/jm500956p | |||
CHEMBL3342686 | 121750 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 449 | 10 | 5 | 5 | 2.6 | Cc1oc(C(c2ccccc2)c2ccccc2)nc1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/jm500956p | |||
101886252 | 121747 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 511 | 11 | 5 | 5 | 4.0 | N=C(N)NCCC[C@H](NC(=O)c1oc(C(c2ccccc2)c2ccccc2)nc1-c1ccccc1)C(=O)O | 10.1021/jm500956p | |||
CHEMBL3342683 | 121747 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 511 | 11 | 5 | 5 | 4.0 | N=C(N)NCCC[C@H](NC(=O)c1oc(C(c2ccccc2)c2ccccc2)nc1-c1ccccc1)C(=O)O | 10.1021/jm500956p | |||
136110886 | 214781 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 389 | 6 | 1 | 2 | 4.5 | Fc1ccc(CC/N=C2\N=C(NCCc3ccc(F)cc3)c3ccccc32)cc1 | 10.1016/s0960-894x(01)00522-4 | |||
CHEMBL97303 | 214781 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 389 | 6 | 1 | 2 | 4.5 | Fc1ccc(CC/N=C2\N=C(NCCc3ccc(F)cc3)c3ccccc32)cc1 | 10.1016/s0960-894x(01)00522-4 | |||
89570147 | 121748 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 462 | 10 | 5 | 5 | 2.4 | Cc1nc(C(c2ccccc2)c2ccccc2)n(C)c1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/jm500956p | |||
CHEMBL3342684 | 121748 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 462 | 10 | 5 | 5 | 2.4 | Cc1nc(C(c2ccccc2)c2ccccc2)n(C)c1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/jm500956p | |||
101886254 | 121744 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 436 | 10 | 5 | 6 | 1.7 | N=C(N)NCCC[C@H](NC(=O)c1nc(C(c2ccccc2)c2ccccc2)no1)C(=O)O | 10.1021/jm500956p | |||
CHEMBL3342680 | 121744 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 436 | 10 | 5 | 6 | 1.7 | N=C(N)NCCC[C@H](NC(=O)c1nc(C(c2ccccc2)c2ccccc2)no1)C(=O)O | 10.1021/jm500956p | |||
CHEMBL1170026 | 215318 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N(C)[C@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/jm1003705 | |||||
101886254 | 121744 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 436 | 10 | 5 | 6 | 1.7 | N=C(N)NCCC[C@H](NC(=O)c1nc(C(c2ccccc2)c2ccccc2)no1)C(=O)O | 10.1021/jm500956p | |||
CHEMBL3342680 | 121744 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 436 | 10 | 5 | 6 | 1.7 | N=C(N)NCCC[C@H](NC(=O)c1nc(C(c2ccccc2)c2ccccc2)no1)C(=O)O | 10.1021/jm500956p | |||
127036518 | 143153 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 509 | 12 | 6 | 7 | 2.2 | CC[C@H](C)[C@H](NC(=O)c1ccc2ccccc2n1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
CHEMBL3735048 | 143153 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 509 | 12 | 6 | 7 | 2.2 | CC[C@H](C)[C@H](NC(=O)c1ccc2ccccc2n1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
127036518 | 143153 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 509 | 12 | 6 | 7 | 2.2 | CC[C@H](C)[C@H](NC(=O)c1ccc2ccccc2n1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
CHEMBL3735048 | 143153 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 509 | 12 | 6 | 7 | 2.2 | CC[C@H](C)[C@H](NC(=O)c1ccc2ccccc2n1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
3529 | 10290 | 9 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 412 | 12 | 4 | 4 | 1.5 | O=C(N[C@H](C(=O)O)CCCN=C(N)N)COCC(c1ccccc1)c1ccccc1 | 10.1021/jm1003705 | |||
5311120 | 10290 | 9 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 412 | 12 | 4 | 4 | 1.5 | O=C(N[C@H](C(=O)O)CCCN=C(N)N)COCC(c1ccccc1)c1ccccc1 | 10.1021/jm1003705 | |||
CHEMBL389348 | 10290 | 9 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 412 | 12 | 4 | 4 | 1.5 | O=C(N[C@H](C(=O)O)CCCN=C(N)N)COCC(c1ccccc1)c1ccccc1 | 10.1021/jm1003705 | |||
CHEMBL1170029 | 215321 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/jm1003705 | |||||
44430538 | 94500 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 461 | 7 | 1 | 3 | 5.1 | Cc1cc(C)cc(C(C(=O)NC2CCN(C(=O)CCc3cccnc3)CC2)C2CCCCC2)c1 | 10.1016/j.bmcl.2007.04.023 | |||
CHEMBL233671 | 94500 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 461 | 7 | 1 | 3 | 5.1 | Cc1cc(C)cc(C(C(=O)NC2CCN(C(=O)CCc3cccnc3)CC2)C2CCCCC2)c1 | 10.1016/j.bmcl.2007.04.023 | |||
44426458 | 93066 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 358 | 8 | 5 | 4 | 1.7 | Cc1cccc(-c2ccc(C(=O)N[C@H](CCCNC(=N)N)C(=O)O)o2)c1 | 10.1016/j.bmcl.2007.04.022 | |||
CHEMBL231303 | 93066 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 358 | 8 | 5 | 4 | 1.7 | Cc1cccc(-c2ccc(C(=O)N[C@H](CCCNC(=N)N)C(=O)O)o2)c1 | 10.1016/j.bmcl.2007.04.022 | |||
136110890 | 214298 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 411 | 7 | 1 | 3 | 4.9 | COc1ccc2c(c1)/C(=N/CCc1ccc(C)cc1)N=C2NCCc1ccc(C)cc1 | 10.1016/s0960-894x(01)00522-4 | |||
CHEMBL94579 | 214298 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 411 | 7 | 1 | 3 | 4.9 | COc1ccc2c(c1)/C(=N/CCc1ccc(C)cc1)N=C2NCCc1ccc(C)cc1 | 10.1016/s0960-894x(01)00522-4 | |||
89570147 | 121748 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 462 | 10 | 5 | 5 | 2.4 | Cc1nc(C(c2ccccc2)c2ccccc2)n(C)c1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/jm500956p | |||
CHEMBL3342684 | 121748 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 462 | 10 | 5 | 5 | 2.4 | Cc1nc(C(c2ccccc2)c2ccccc2)n(C)c1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/jm500956p | |||
44430555 | 94825 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 451 | 7 | 1 | 3 | 4.6 | O=C(NC1CCN(C(=O)CCc2ccc(F)nc2)CC1)C(c1ccccc1)C1CCCCC1 | 10.1016/j.bmcl.2007.04.023 | |||
CHEMBL234522 | 94825 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 451 | 7 | 1 | 3 | 4.6 | O=C(NC1CCN(C(=O)CCc2ccc(F)nc2)CC1)C(c1ccccc1)C1CCCCC1 | 10.1016/j.bmcl.2007.04.023 | |||
44430560 | 94946 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 448 | 6 | 1 | 2 | 5.3 | O=C(NC1CCN(C(=O)/C=C/c2ccccc2F)CC1)C(c1ccccc1)C1CCCCC1 | 10.1016/j.bmcl.2007.04.023 | |||
CHEMBL234731 | 94946 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 448 | 6 | 1 | 2 | 5.3 | O=C(NC1CCN(C(=O)/C=C/c2ccccc2F)CC1)C(c1ccccc1)C1CCCCC1 | 10.1016/j.bmcl.2007.04.023 | |||
44430514 | 157021 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 427 | 7 | 1 | 3 | 4.0 | O=C(NC1CCN(C(=O)CCc2cccnc2)CC1)C(c1ccccc1)c1ccccc1 | 10.1016/j.bmcl.2007.04.023 | |||
CHEMBL395233 | 157021 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 427 | 7 | 1 | 3 | 4.0 | O=C(NC1CCN(C(=O)CCc2cccnc2)CC1)C(c1ccccc1)c1ccccc1 | 10.1016/j.bmcl.2007.04.023 | |||
CHEMBL1170026 | 215318 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N(C)[C@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/jm1003705 | |||||
136110896 | 114501 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 390 | 6 | 1 | 3 | 3.9 | Fc1ccc(CC/N=C2\N=C(NCCc3ccc(F)cc3)c3cnccc32)cc1 | 10.1016/s0960-894x(01)00522-4 | |||
CHEMBL319113 | 114501 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 390 | 6 | 1 | 3 | 3.9 | Fc1ccc(CC/N=C2\N=C(NCCc3ccc(F)cc3)c3cnccc32)cc1 | 10.1016/s0960-894x(01)00522-4 | |||
71566653 | 143208 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 548 | 14 | 6 | 6 | 3.2 | CC[C@H](C)[C@H](NC(=O)C(c1ccccc1)c1ccccc1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
CHEMBL3735554 | 143208 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 548 | 14 | 6 | 6 | 3.2 | CC[C@H](C)[C@H](NC(=O)C(c1ccccc1)c1ccccc1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
71566653 | 143208 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 548 | 14 | 6 | 6 | 3.2 | CC[C@H](C)[C@H](NC(=O)C(c1ccccc1)c1ccccc1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
CHEMBL3735554 | 143208 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 548 | 14 | 6 | 6 | 3.2 | CC[C@H](C)[C@H](NC(=O)C(c1ccccc1)c1ccccc1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
127034744 | 143184 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 468 | 11 | 6 | 7 | 2.0 | Cc1oc([C@H](CC(C)C)NC(=O)OC(C)(C)C)nc1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1016/j.bmcl.2015.10.038 | |||
CHEMBL3735339 | 143184 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 468 | 11 | 6 | 7 | 2.0 | Cc1oc([C@H](CC(C)C)NC(=O)OC(C)(C)C)nc1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1016/j.bmcl.2015.10.038 | |||
3529 | 10290 | 9 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 412 | 12 | 4 | 4 | 1.5 | O=C(N[C@H](C(=O)O)CCCN=C(N)N)COCC(c1ccccc1)c1ccccc1 | 10.1021/jm1003705 | |||
5311120 | 10290 | 9 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 412 | 12 | 4 | 4 | 1.5 | O=C(N[C@H](C(=O)O)CCCN=C(N)N)COCC(c1ccccc1)c1ccccc1 | 10.1021/jm1003705 | |||
CHEMBL389348 | 10290 | 9 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 412 | 12 | 4 | 4 | 1.5 | O=C(N[C@H](C(=O)O)CCCN=C(N)N)COCC(c1ccccc1)c1ccccc1 | 10.1021/jm1003705 | |||
CHEMBL1170029 | 215321 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/jm1003705 | |||||
71565581 | 143126 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 546 | 12 | 6 | 6 | 3.1 | CC(C)C[C@H](NC(=O)C1c2ccccc2-c2ccccc21)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
CHEMBL3734765 | 143126 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 546 | 12 | 6 | 6 | 3.1 | CC(C)C[C@H](NC(=O)C1c2ccccc2-c2ccccc21)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
71565581 | 143126 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 546 | 12 | 6 | 6 | 3.1 | CC(C)C[C@H](NC(=O)C1c2ccccc2-c2ccccc21)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
CHEMBL3734765 | 143126 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 546 | 12 | 6 | 6 | 3.1 | CC(C)C[C@H](NC(=O)C1c2ccccc2-c2ccccc21)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
44426496 | 148820 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 502 | 10 | 5 | 4 | 4.2 | N=C(N)NCCC[C@@H](NC(=O)c1ccc(C(c2cccc(Cl)c2)c2cccc(Cl)c2)o1)C(=O)O | 10.1016/j.bmcl.2007.04.022 | |||
CHEMBL387755 | 148820 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 502 | 10 | 5 | 4 | 4.2 | N=C(N)NCCC[C@@H](NC(=O)c1ccc(C(c2cccc(Cl)c2)c2cccc(Cl)c2)o1)C(=O)O | 10.1016/j.bmcl.2007.04.022 | |||
101886253 | 121742 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 411 | 12 | 6 | 4 | 1.2 | N=C(N)NCCC[C@H](NC(=O)CNCC(c1ccccc1)c1ccccc1)C(=O)O | 10.1021/jm500956p | |||
CHEMBL3342678 | 121742 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 411 | 12 | 6 | 4 | 1.2 | N=C(N)NCCC[C@H](NC(=O)CNCC(c1ccccc1)c1ccccc1)C(=O)O | 10.1021/jm500956p | |||
71565580 | 143262 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 590 | 16 | 6 | 7 | 3.7 | CC[C@H](C)[C@H](NC(=O)CCC(=O)c1ccc(-c2ccccc2)cc1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
CHEMBL3736125 | 143262 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 590 | 16 | 6 | 7 | 3.7 | CC[C@H](C)[C@H](NC(=O)CCC(=O)c1ccc(-c2ccccc2)cc1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
71565506 | 143254 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 511 | 13 | 7 | 6 | 2.0 | CC[C@H](C)[C@H](NC(=O)Cc1c[nH]c2ccccc12)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
CHEMBL3735993 | 143254 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 511 | 13 | 7 | 6 | 2.0 | CC[C@H](C)[C@H](NC(=O)Cc1c[nH]c2ccccc12)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
71565506 | 143254 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 511 | 13 | 7 | 6 | 2.0 | CC[C@H](C)[C@H](NC(=O)Cc1c[nH]c2ccccc12)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
CHEMBL3735993 | 143254 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 511 | 13 | 7 | 6 | 2.0 | CC[C@H](C)[C@H](NC(=O)Cc1c[nH]c2ccccc12)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
CHEMBL1170639 | 215349 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | None | None | None | None | 10.1021/jm1003705 | |||||
71565580 | 143262 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 590 | 16 | 6 | 7 | 3.7 | CC[C@H](C)[C@H](NC(=O)CCC(=O)c1ccc(-c2ccccc2)cc1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
CHEMBL3736125 | 143262 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 590 | 16 | 6 | 7 | 3.7 | CC[C@H](C)[C@H](NC(=O)CCC(=O)c1ccc(-c2ccccc2)cc1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
CHEMBL1170639 | 215349 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | None | None | None | None | 10.1021/jm1003705 | |||||
71565509 | 143202 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 562 | 14 | 6 | 7 | 2.9 | CC[C@H](C)[C@H](NC(=O)c1ccc(C(=O)c2ccccc2)cc1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
CHEMBL3735465 | 143202 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 562 | 14 | 6 | 7 | 2.9 | CC[C@H](C)[C@H](NC(=O)c1ccc(C(=O)c2ccccc2)cc1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
101886253 | 121742 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 411 | 12 | 6 | 4 | 1.2 | N=C(N)NCCC[C@H](NC(=O)CNCC(c1ccccc1)c1ccccc1)C(=O)O | 10.1021/jm500956p | |||
CHEMBL3342678 | 121742 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 411 | 12 | 6 | 4 | 1.2 | N=C(N)NCCC[C@H](NC(=O)CNCC(c1ccccc1)c1ccccc1)C(=O)O | 10.1021/jm500956p | |||
71565509 | 143202 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 562 | 14 | 6 | 7 | 2.9 | CC[C@H](C)[C@H](NC(=O)c1ccc(C(=O)c2ccccc2)cc1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
CHEMBL3735465 | 143202 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 562 | 14 | 6 | 7 | 2.9 | CC[C@H](C)[C@H](NC(=O)c1ccc(C(=O)c2ccccc2)cc1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
44430548 | 94731 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 451 | 7 | 1 | 3 | 4.6 | O=C(NC1CCN(C(=O)CCc2cccnc2)CC1)C(c1ccc(F)cc1)C1CCCCC1 | 10.1016/j.bmcl.2007.04.023 | |||
CHEMBL234101 | 94731 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 451 | 7 | 1 | 3 | 4.6 | O=C(NC1CCN(C(=O)CCc2cccnc2)CC1)C(c1ccc(F)cc1)C1CCCCC1 | 10.1016/j.bmcl.2007.04.023 | |||
44426497 | 92510 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 502 | 10 | 5 | 4 | 4.2 | N=C(N)NCCC[C@@H](NC(=O)c1ccc(C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)o1)C(=O)O | 10.1016/j.bmcl.2007.04.022 | |||
CHEMBL229006 | 92510 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 502 | 10 | 5 | 4 | 4.2 | N=C(N)NCCC[C@@H](NC(=O)c1ccc(C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)o1)C(=O)O | 10.1016/j.bmcl.2007.04.022 | |||
CHEMBL1169838 | 215316 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | None | None | None | None | 10.1021/jm1003705 | |||||
44430510 | 165897 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 509 | 5 | 1 | 4 | 5.4 | O=C(NC1CCN(C(=O)CCc2cccnc2)CC1)C1c2cc(Cl)ccc2Oc2ccc(Cl)cc21 | 10.1016/j.bmcl.2007.04.023 | |||
CHEMBL409773 | 165897 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 509 | 5 | 1 | 4 | 5.4 | O=C(NC1CCN(C(=O)CCc2cccnc2)CC1)C1c2cc(Cl)ccc2Oc2ccc(Cl)cc21 | 10.1016/j.bmcl.2007.04.023 | |||
44426466 | 148812 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 412 | 8 | 5 | 4 | 2.7 | N=C(N)NCCC[C@@H](NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1)C(=O)O | 10.1016/j.bmcl.2007.04.022 | |||
CHEMBL387686 | 148812 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 412 | 8 | 5 | 4 | 2.7 | N=C(N)NCCC[C@@H](NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1)C(=O)O | 10.1016/j.bmcl.2007.04.022 | |||
44430553 | 94824 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 463 | 8 | 1 | 4 | 4.5 | COc1ncccc1CCC(=O)N1CCC(NC(=O)C(c2ccccc2)C2CCCCC2)CC1 | 10.1016/j.bmcl.2007.04.023 | |||
CHEMBL234521 | 94824 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 463 | 8 | 1 | 4 | 4.5 | COc1ncccc1CCC(=O)N1CCC(NC(=O)C(c2ccccc2)C2CCCCC2)CC1 | 10.1016/j.bmcl.2007.04.023 | |||
CHEMBL1169838 | 215316 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | None | None | None | None | 10.1021/jm1003705 | |||||
CHEMBL1170436 | 215342 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | None | None | None | None | 10.1021/jm1003705 | |||||
CHEMBL1170436 | 215342 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | None | None | None | None | 10.1021/jm1003705 | |||||
135418443 | 114697 | 3 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 353 | 4 | 1 | 2 | 4.8 | Cc1ccc(C/N=C2\N=C(NCc3ccc(C)cc3)c3ccccc32)cc1 | 10.1016/s0960-894x(01)00522-4 | |||
CHEMBL319332 | 114697 | 3 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 353 | 4 | 1 | 2 | 4.8 | Cc1ccc(C/N=C2\N=C(NCc3ccc(C)cc3)c3ccccc32)cc1 | 10.1016/s0960-894x(01)00522-4 | |||
71566580 | 121749 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 435 | 10 | 5 | 5 | 2.3 | N=C(N)NCCC[C@H](NC(=O)c1coc(C(c2ccccc2)c2ccccc2)n1)C(=O)O | 10.1021/jm500956p | |||
CHEMBL3342685 | 121749 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 435 | 10 | 5 | 5 | 2.3 | N=C(N)NCCC[C@H](NC(=O)c1coc(C(c2ccccc2)c2ccccc2)n1)C(=O)O | 10.1021/jm500956p | |||
71768012 | 143230 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 454 | 11 | 6 | 7 | 1.7 | CC(C)C[C@H](NC(=O)OC(C)(C)C)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
CHEMBL3735760 | 143230 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 454 | 11 | 6 | 7 | 1.7 | CC(C)C[C@H](NC(=O)OC(C)(C)C)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
71566580 | 121749 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 435 | 10 | 5 | 5 | 2.3 | N=C(N)NCCC[C@H](NC(=O)c1coc(C(c2ccccc2)c2ccccc2)n1)C(=O)O | 10.1021/jm500956p | |||
CHEMBL3342685 | 121749 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 435 | 10 | 5 | 5 | 2.3 | N=C(N)NCCC[C@H](NC(=O)c1coc(C(c2ccccc2)c2ccccc2)n1)C(=O)O | 10.1021/jm500956p | |||
44430541 | 94501 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 467 | 7 | 1 | 3 | 5.1 | O=C(NC1CCN(C(=O)CCc2cccnc2)CC1)C(c1ccc(Cl)cc1)C1CCCCC1 | 10.1016/j.bmcl.2007.04.023 | |||
CHEMBL233675 | 94501 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 467 | 7 | 1 | 3 | 5.1 | O=C(NC1CCN(C(=O)CCc2cccnc2)CC1)C(c1ccc(Cl)cc1)C1CCCCC1 | 10.1016/j.bmcl.2007.04.023 | |||
44431783 | 94715 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 439 | 7 | 1 | 4 | 4.5 | O=C(NC1CCN(C(=O)CCc2cccnc2)CC1)C(c1ccsc1)C1CCCCC1 | 10.1016/j.bmcl.2007.04.023 | |||
CHEMBL234005 | 94715 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 439 | 7 | 1 | 4 | 4.5 | O=C(NC1CCN(C(=O)CCc2cccnc2)CC1)C(c1ccsc1)C1CCCCC1 | 10.1016/j.bmcl.2007.04.023 | |||
44426462 | 93168 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 369 | 8 | 5 | 5 | 1.3 | N#Cc1cccc(-c2ccc(C(=O)N[C@H](CCCNC(=N)N)C(=O)O)o2)c1 | 10.1016/j.bmcl.2007.04.022 | |||
CHEMBL231404 | 93168 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 369 | 8 | 5 | 5 | 1.3 | N#Cc1cccc(-c2ccc(C(=O)N[C@H](CCCNC(=N)N)C(=O)O)o2)c1 | 10.1016/j.bmcl.2007.04.022 | |||
44426464 | 103686 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 396 | 8 | 5 | 4 | 2.2 | N=C(N)NCCC[C@@H](NC(=O)c1ccc(-c2ccc(F)c(Cl)c2)o1)C(=O)O | 10.1016/j.bmcl.2007.04.022 | |||
CHEMBL265866 | 103686 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 396 | 8 | 5 | 4 | 2.2 | N=C(N)NCCC[C@@H](NC(=O)c1ccc(-c2ccc(F)c(Cl)c2)o1)C(=O)O | 10.1016/j.bmcl.2007.04.022 | |||
44426460 | 173109 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 388 | 10 | 5 | 5 | 1.8 | CCOc1cccc(-c2ccc(C(=O)N[C@H](CCCNC(=N)N)C(=O)O)o2)c1 | 10.1016/j.bmcl.2007.04.022 | |||
CHEMBL427268 | 173109 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 388 | 10 | 5 | 5 | 1.8 | CCOc1cccc(-c2ccc(C(=O)N[C@H](CCCNC(=N)N)C(=O)O)o2)c1 | 10.1016/j.bmcl.2007.04.022 | |||
44430546 | 94730 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 465 | 7 | 1 | 3 | 4.9 | O=C(NC1CCN(C(=O)CCc2cccnc2)CC1)C(c1ccccc1Cl)C1C=CCCC1 | 10.1016/j.bmcl.2007.04.023 | |||
CHEMBL234100 | 94730 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 465 | 7 | 1 | 3 | 4.9 | O=C(NC1CCN(C(=O)CCc2cccnc2)CC1)C(c1ccccc1Cl)C1C=CCCC1 | 10.1016/j.bmcl.2007.04.023 | |||
44430558 | 158285 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 450 | 7 | 1 | 2 | 5.2 | O=C(NC1CCN(C(=O)CCc2ccccc2F)CC1)C(c1ccccc1)C1CCCCC1 | 10.1016/j.bmcl.2007.04.023 | |||
CHEMBL396262 | 158285 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 450 | 7 | 1 | 2 | 5.2 | O=C(NC1CCN(C(=O)CCc2ccccc2F)CC1)C(c1ccccc1)C1CCCCC1 | 10.1016/j.bmcl.2007.04.023 | |||
44430516 | 93780 | 0 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 495 | 7 | 1 | 3 | 5.3 | O=C(NC1CCN(C(=O)CCc2cccnc2)CC1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2007.04.023 | |||
CHEMBL232418 | 93780 | 0 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 495 | 7 | 1 | 3 | 5.3 | O=C(NC1CCN(C(=O)CCc2cccnc2)CC1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2007.04.023 | |||
155534696 | 178758 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 464 | 10 | 5 | 4 | 3.7 | Cc1cc(C(c2ccccc2)c2ccccc2)sc1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/acs.jmedchem.9b00927 | |||
CHEMBL4470864 | 178758 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 464 | 10 | 5 | 4 | 3.7 | Cc1cc(C(c2ccccc2)c2ccccc2)sc1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/acs.jmedchem.9b00927 | |||
3915 | 8307 | 11 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | None | None | None | None | 10.1021/jm1003705 | |||||
49799079 | 8307 | 11 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | None | None | None | None | 10.1021/jm1003705 | |||||
5760 | 8307 | 11 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | None | None | None | None | 10.1021/jm1003705 | |||||
91933514 | 8307 | 11 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | None | None | None | None | 10.1021/jm1003705 | |||||
CHEMBL1170024 | 8307 | 11 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | None | None | None | None | 10.1021/jm1003705 | |||||
71768012 | 143230 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 454 | 11 | 6 | 7 | 1.7 | CC(C)C[C@H](NC(=O)OC(C)(C)C)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
CHEMBL3735760 | 143230 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 454 | 11 | 6 | 7 | 1.7 | CC(C)C[C@H](NC(=O)OC(C)(C)C)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
3529 | 10290 | 9 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 412 | 12 | 4 | 4 | 1.5 | O=C(N[C@H](C(=O)O)CCCN=C(N)N)COCC(c1ccccc1)c1ccccc1 | 10.1021/acs.jmedchem.7b00882 | |||
5311120 | 10290 | 9 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 412 | 12 | 4 | 4 | 1.5 | O=C(N[C@H](C(=O)O)CCCN=C(N)N)COCC(c1ccccc1)c1ccccc1 | 10.1021/acs.jmedchem.7b00882 | |||
CHEMBL389348 | 10290 | 9 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 412 | 12 | 4 | 4 | 1.5 | O=C(N[C@H](C(=O)O)CCCN=C(N)N)COCC(c1ccccc1)c1ccccc1 | 10.1021/acs.jmedchem.7b00882 | |||
CHEMBL1170042 | 215327 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | None | None | None | None | 10.1021/jm1003705 | |||||
CHEMBL1170644 | 215353 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CC1CCCCC1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)[C@@H](C)O | 10.1021/jm1003705 | |||||
CHEMBL1170644 | 215353 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CC1CCCCC1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)[C@@H](C)O | 10.1021/jm1003705 | |||||
CHEMBL1170230 | 215336 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | None | None | None | None | 10.1021/jm1003705 | |||||
CHEMBL1170230 | 215336 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | None | None | None | None | 10.1021/jm1003705 | |||||
CHEMBL1170025 | 215317 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | None | None | None | None | 10.1021/jm1003705 | |||||
CHEMBL1170025 | 215317 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | None | None | None | None | 10.1021/jm1003705 | |||||
44430536 | 93529 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 447 | 7 | 1 | 3 | 4.8 | Cc1ccccc1C(C(=O)NC1CCN(C(=O)CCc2cccnc2)CC1)C1CCCCC1 | 10.1016/j.bmcl.2007.04.023 | |||
CHEMBL232029 | 93529 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 447 | 7 | 1 | 3 | 4.8 | Cc1ccccc1C(C(=O)NC1CCN(C(=O)CCc2cccnc2)CC1)C1CCCCC1 | 10.1016/j.bmcl.2007.04.023 | |||
44430529 | 94102 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 445 | 7 | 1 | 3 | 4.8 | O=C(NC1CCN(C(=O)CCc2cccnc2)CC1)/C(=C/C1CCCCC1)c1ccccc1 | 10.1016/j.bmcl.2007.04.023 | |||
CHEMBL233232 | 94102 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 445 | 7 | 1 | 3 | 4.8 | O=C(NC1CCN(C(=O)CCc2cccnc2)CC1)/C(=C/C1CCCCC1)c1ccccc1 | 10.1016/j.bmcl.2007.04.023 | |||
71566652 | 143316 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 458 | 12 | 6 | 6 | 1.6 | CC[C@H](C)[C@H](NC(=O)c1ccccc1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
CHEMBL3736519 | 143316 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 458 | 12 | 6 | 6 | 1.6 | CC[C@H](C)[C@H](NC(=O)c1ccccc1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
71566652 | 143316 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 458 | 12 | 6 | 6 | 1.6 | CC[C@H](C)[C@H](NC(=O)c1ccccc1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
CHEMBL3736519 | 143316 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 458 | 12 | 6 | 6 | 1.6 | CC[C@H](C)[C@H](NC(=O)c1ccccc1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
CHEMBL1170033 | 215324 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | None | None | None | None | 10.1021/jm1003705 | |||||
CHEMBL1170046 | 215331 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | None | None | None | None | 10.1021/jm1003705 | |||||
CHEMBL1170046 | 215331 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | None | None | None | None | 10.1021/jm1003705 | |||||
71566581 | 143282 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 454 | 11 | 6 | 7 | 1.7 | CC[C@H](C)[C@H](NC(=O)OC(C)(C)C)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
CHEMBL3736239 | 143282 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 454 | 11 | 6 | 7 | 1.7 | CC[C@H](C)[C@H](NC(=O)OC(C)(C)C)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
25156014 | 182228 | 2 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 450 | 10 | 5 | 4 | 3.4 | N=C(N)NCCC[C@H](NC(=O)c1ccc(C(c2ccccc2)c2ccccc2)s1)C(=O)O | 10.1021/acs.jmedchem.9b00927 | |||
CHEMBL4576800 | 182228 | 2 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 450 | 10 | 5 | 4 | 3.4 | N=C(N)NCCC[C@H](NC(=O)c1ccc(C(c2ccccc2)c2ccccc2)s1)C(=O)O | 10.1021/acs.jmedchem.9b00927 | |||
71566581 | 143282 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 454 | 11 | 6 | 7 | 1.7 | CC[C@H](C)[C@H](NC(=O)OC(C)(C)C)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
CHEMBL3736239 | 143282 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 454 | 11 | 6 | 7 | 1.7 | CC[C@H](C)[C@H](NC(=O)OC(C)(C)C)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
101886250 | 121753 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 462 | 10 | 5 | 5 | 2.4 | Cc1c(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)nc(C(c2ccccc2)c2ccccc2)n1C | 10.1021/jm500956p | |||
CHEMBL3342690 | 121753 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 462 | 10 | 5 | 5 | 2.4 | Cc1c(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)nc(C(c2ccccc2)c2ccccc2)n1C | 10.1021/jm500956p | |||
101886250 | 121753 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 462 | 10 | 5 | 5 | 2.4 | Cc1c(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)nc(C(c2ccccc2)c2ccccc2)n1C | 10.1021/jm500956p | |||
CHEMBL3342690 | 121753 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 462 | 10 | 5 | 5 | 2.4 | Cc1c(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)nc(C(c2ccccc2)c2ccccc2)n1C | 10.1021/jm500956p | |||
44430554 | 158048 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 451 | 7 | 1 | 3 | 4.6 | O=C(NC1CCN(C(=O)CCc2cccnc2F)CC1)C(c1ccccc1)C1CCCCC1 | 10.1016/j.bmcl.2007.04.023 | |||
CHEMBL396031 | 158048 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 451 | 7 | 1 | 3 | 4.6 | O=C(NC1CCN(C(=O)CCc2cccnc2F)CC1)C(c1ccccc1)C1CCCCC1 | 10.1016/j.bmcl.2007.04.023 | |||
44426495 | 92509 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 470 | 10 | 5 | 4 | 3.2 | N=C(N)NCCC[C@@H](NC(=O)c1ccc(C(c2cccc(F)c2)c2cccc(F)c2)o1)C(=O)O | 10.1016/j.bmcl.2007.04.022 | |||
CHEMBL229005 | 92509 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 470 | 10 | 5 | 4 | 3.2 | N=C(N)NCCC[C@@H](NC(=O)c1ccc(C(c2cccc(F)c2)c2cccc(F)c2)o1)C(=O)O | 10.1016/j.bmcl.2007.04.022 | |||
11252 | 7557 | 39 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 433 | 7 | 1 | 3 | 4.5 | O=C(N1CCC(CC1)NC(=O)C(c1ccccc1)C1CCCCC1)CCc1cccnc1 | 10.1016/j.bmcl.2007.04.023 | |||
44430519 | 7557 | 39 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 433 | 7 | 1 | 3 | 4.5 | O=C(N1CCC(CC1)NC(=O)C(c1ccccc1)C1CCCCC1)CCc1cccnc1 | 10.1016/j.bmcl.2007.04.023 | |||
CHEMBL390036 | 7557 | 39 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 433 | 7 | 1 | 3 | 4.5 | O=C(N1CCC(CC1)NC(=O)C(c1ccccc1)C1CCCCC1)CCc1cccnc1 | 10.1016/j.bmcl.2007.04.023 | |||
44430550 | 94778 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 478 | 8 | 1 | 5 | 4.4 | O=C(NC1CCN(C(=O)CCc2cccnc2)CC1)C(c1ccc([N+](=O)[O-])cc1)C1CCCCC1 | 10.1016/j.bmcl.2007.04.023 | |||
CHEMBL234304 | 94778 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 478 | 8 | 1 | 5 | 4.4 | O=C(NC1CCN(C(=O)CCc2cccnc2)CC1)C(c1ccc([N+](=O)[O-])cc1)C1CCCCC1 | 10.1016/j.bmcl.2007.04.023 | |||
44426469 | 92454 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 400 | 8 | 5 | 5 | 2.6 | N=C(N)NCCC[C@@H](NC(=O)c1ccc(-c2csc3ccccc23)o1)C(=O)O | 10.1016/j.bmcl.2007.04.022 | |||
CHEMBL228634 | 92454 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 400 | 8 | 5 | 5 | 2.6 | N=C(N)NCCC[C@@H](NC(=O)c1ccc(-c2csc3ccccc23)o1)C(=O)O | 10.1016/j.bmcl.2007.04.022 | |||
44426457 | 149655 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 362 | 8 | 5 | 4 | 1.5 | N=C(N)NCCC[C@@H](NC(=O)c1ccc(-c2cccc(F)c2)o1)C(=O)O | 10.1016/j.bmcl.2007.04.022 | |||
CHEMBL389349 | 149655 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 362 | 8 | 5 | 4 | 1.5 | N=C(N)NCCC[C@@H](NC(=O)c1ccc(-c2cccc(F)c2)o1)C(=O)O | 10.1016/j.bmcl.2007.04.022 | |||
44426459 | 156152 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 374 | 9 | 5 | 5 | 1.4 | COc1cccc(-c2ccc(C(=O)N[C@H](CCCNC(=N)N)C(=O)O)o2)c1 | 10.1016/j.bmcl.2007.04.022 | |||
CHEMBL394538 | 156152 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 374 | 9 | 5 | 5 | 1.4 | COc1cccc(-c2ccc(C(=O)N[C@H](CCCNC(=N)N)C(=O)O)o2)c1 | 10.1016/j.bmcl.2007.04.022 | |||
44430532 | 94104 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 417 | 7 | 1 | 3 | 3.9 | O=C(NC1CCN(C(=O)CCc2cccnc2)CC1)C(c1ccccc1)C1CC=CC1 | 10.1016/j.bmcl.2007.04.023 | |||
CHEMBL233234 | 94104 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 417 | 7 | 1 | 3 | 3.9 | O=C(NC1CCN(C(=O)CCc2cccnc2)CC1)C(c1ccccc1)C1CC=CC1 | 10.1016/j.bmcl.2007.04.023 | |||
CHEMBL1170033 | 215324 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm1003705 | |||||
136110895 | 214571 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 410 | 5 | 2 | 3 | 4.8 | CC(=O)Nc1ccc2c(c1)/C(=N\Cc1ccc(C)cc1)N=C2NCc1ccc(C)cc1 | 10.1016/s0960-894x(01)00522-4 | |||
CHEMBL96138 | 214571 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 410 | 5 | 2 | 3 | 4.8 | CC(=O)Nc1ccc2c(c1)/C(=N\Cc1ccc(C)cc1)N=C2NCc1ccc(C)cc1 | 10.1016/s0960-894x(01)00522-4 | |||
44426470 | 92455 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 434 | 8 | 5 | 5 | 3.3 | N=C(N)NCCC[C@@H](NC(=O)c1ccc(-c2cccc3c2oc2ccccc23)o1)C(=O)O | 10.1016/j.bmcl.2007.04.022 | |||
CHEMBL228635 | 92455 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 434 | 8 | 5 | 5 | 3.3 | N=C(N)NCCC[C@@H](NC(=O)c1ccc(-c2cccc3c2oc2ccccc23)o1)C(=O)O | 10.1016/j.bmcl.2007.04.022 | |||
25156014 | 182228 | 2 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 450 | 10 | 5 | 4 | 3.4 | N=C(N)NCCC[C@H](NC(=O)c1ccc(C(c2ccccc2)c2ccccc2)s1)C(=O)O | 10.1021/acs.jmedchem.9b00927 | |||
CHEMBL4576800 | 182228 | 2 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 450 | 10 | 5 | 4 | 3.4 | N=C(N)NCCC[C@H](NC(=O)c1ccc(C(c2ccccc2)c2ccccc2)s1)C(=O)O | 10.1021/acs.jmedchem.9b00927 | |||
CHEMBL1170638 | 215348 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm1003705 | |||||
CHEMBL1170638 | 215348 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm1003705 | |||||
127034742 | 143245 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 617 | 14 | 6 | 7 | 3.3 | CC(C)C[C@H](NC(=O)C(C)c1ccc(N2Cc3ccccc3C2=O)cc1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
CHEMBL3735887 | 143245 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 617 | 14 | 6 | 7 | 3.3 | CC(C)C[C@H](NC(=O)C(C)c1ccc(N2Cc3ccccc3C2=O)cc1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
127034742 | 143245 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 617 | 14 | 6 | 7 | 3.3 | CC(C)C[C@H](NC(=O)C(C)c1ccc(N2Cc3ccccc3C2=O)cc1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
CHEMBL3735887 | 143245 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 617 | 14 | 6 | 7 | 3.3 | CC(C)C[C@H](NC(=O)C(C)c1ccc(N2Cc3ccccc3C2=O)cc1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
136110894 | 214802 | 0 | None | - | 0 | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 449 | 6 | 1 | 2 | 6.2 | Cc1ccc(CC/N=C2\N=C(NCCc3ccc(C)cc3)c3cc(Cl)c(Cl)cc32)cc1 | 10.1016/s0960-894x(01)00522-4 | |||
CHEMBL97420 | 214802 | 0 | None | - | 0 | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 449 | 6 | 1 | 2 | 6.2 | Cc1ccc(CC/N=C2\N=C(NCCc3ccc(C)cc3)c3cc(Cl)c(Cl)cc32)cc1 | 10.1016/s0960-894x(01)00522-4 | |||
71525749 | 143207 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 537 | 12 | 6 | 7 | 1.8 | CC[C@H](C)[C@H](NC(=O)c1cncc(Br)c1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
CHEMBL3735507 | 143207 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 537 | 12 | 6 | 7 | 1.8 | CC[C@H](C)[C@H](NC(=O)c1cncc(Br)c1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
71525749 | 143207 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 537 | 12 | 6 | 7 | 1.8 | CC[C@H](C)[C@H](NC(=O)c1cncc(Br)c1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
CHEMBL3735507 | 143207 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 537 | 12 | 6 | 7 | 1.8 | CC[C@H](C)[C@H](NC(=O)c1cncc(Br)c1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
24829327 | 172237 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 463 | 9 | 5 | 5 | 1.1 | N=C(N)NCCC[C@H](NC(=O)c1cccn(Cc2ccccc2Br)c1=O)C(=O)O | 10.1021/acs.jmedchem.7b00882 | |||
CHEMBL4239466 | 172237 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 463 | 9 | 5 | 5 | 1.1 | N=C(N)NCCC[C@H](NC(=O)c1cccn(Cc2ccccc2Br)c1=O)C(=O)O | 10.1021/acs.jmedchem.7b00882 | |||
17753143 | 92715 | 4 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 434 | 10 | 5 | 4 | 2.9 | N=C(N)NCCC[C@H](NC(=O)c1ccc(C(c2ccccc2)c2ccccc2)o1)C(=O)O | 10.1021/jm500956p | |||
CHEMBL230034 | 92715 | 4 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 434 | 10 | 5 | 4 | 2.9 | N=C(N)NCCC[C@H](NC(=O)c1ccc(C(c2ccccc2)c2ccccc2)o1)C(=O)O | 10.1021/jm500956p | |||
101886249 | 121745 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 436 | 10 | 5 | 6 | 1.7 | N=C(N)NCCC[C@H](NC(=O)c1noc(C(c2ccccc2)c2ccccc2)n1)C(=O)O | 10.1021/jm500956p | |||
CHEMBL3342681 | 121745 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 436 | 10 | 5 | 6 | 1.7 | N=C(N)NCCC[C@H](NC(=O)c1noc(C(c2ccccc2)c2ccccc2)n1)C(=O)O | 10.1021/jm500956p | |||
44430547 | 175638 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 465 | 7 | 1 | 3 | 4.9 | O=C(NC1CCN(C(=O)CCc2cccnc2)CC1)C(c1cccc(Cl)c1)C1C=CCCC1 | 10.1016/j.bmcl.2007.04.023 | |||
CHEMBL438129 | 175638 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 465 | 7 | 1 | 3 | 4.9 | O=C(NC1CCN(C(=O)CCc2cccnc2)CC1)C(c1cccc(Cl)c1)C1C=CCCC1 | 10.1016/j.bmcl.2007.04.023 | |||
3529 | 10290 | 9 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 412 | 12 | 4 | 4 | 1.5 | O=C(N[C@H](C(=O)O)CCCN=C(N)N)COCC(c1ccccc1)c1ccccc1 | 10.1021/acs.jmedchem.9b00927 | |||
5311120 | 10290 | 9 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 412 | 12 | 4 | 4 | 1.5 | O=C(N[C@H](C(=O)O)CCCN=C(N)N)COCC(c1ccccc1)c1ccccc1 | 10.1021/acs.jmedchem.9b00927 | |||
CHEMBL389348 | 10290 | 9 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 412 | 12 | 4 | 4 | 1.5 | O=C(N[C@H](C(=O)O)CCCN=C(N)N)COCC(c1ccccc1)c1ccccc1 | 10.1021/acs.jmedchem.9b00927 | |||
3529 | 10290 | 9 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 412 | 12 | 4 | 4 | 1.5 | O=C(N[C@H](C(=O)O)CCCN=C(N)N)COCC(c1ccccc1)c1ccccc1 | 10.1016/j.bmcl.2007.04.022 | |||
5311120 | 10290 | 9 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 412 | 12 | 4 | 4 | 1.5 | O=C(N[C@H](C(=O)O)CCCN=C(N)N)COCC(c1ccccc1)c1ccccc1 | 10.1016/j.bmcl.2007.04.022 | |||
CHEMBL389348 | 10290 | 9 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 412 | 12 | 4 | 4 | 1.5 | O=C(N[C@H](C(=O)O)CCCN=C(N)N)COCC(c1ccccc1)c1ccccc1 | 10.1016/j.bmcl.2007.04.022 | |||
11252 | 7557 | 39 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 433 | 7 | 1 | 3 | 4.5 | O=C(N1CCC(CC1)NC(=O)C(c1ccccc1)C1CCCCC1)CCc1cccnc1 | 10.1016/j.bmcl.2007.04.023 | |||
44430519 | 7557 | 39 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 433 | 7 | 1 | 3 | 4.5 | O=C(N1CCC(CC1)NC(=O)C(c1ccccc1)C1CCCCC1)CCc1cccnc1 | 10.1016/j.bmcl.2007.04.023 | |||
CHEMBL390036 | 7557 | 39 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 433 | 7 | 1 | 3 | 4.5 | O=C(N1CCC(CC1)NC(=O)C(c1ccccc1)C1CCCCC1)CCc1cccnc1 | 10.1016/j.bmcl.2007.04.023 | |||
44430557 | 94944 | 0 | None | - | 0 | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 445 | 6 | 1 | 3 | 4.9 | Cc1cncc(/C=C/C(=O)N2CCC(NC(=O)C(c3ccccc3)C3CCCCC3)CC2)c1 | 10.1016/j.bmcl.2007.04.023 | |||
CHEMBL234729 | 94944 | 0 | None | - | 0 | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 445 | 6 | 1 | 3 | 4.9 | Cc1cncc(/C=C/C(=O)N2CCC(NC(=O)C(c3ccccc3)C3CCCCC3)CC2)c1 | 10.1016/j.bmcl.2007.04.023 | |||
44426478 | 92492 | 0 | None | - | 0 | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 452 | 9 | 5 | 4 | 1.8 | N=C(N)NCCC[C@@H](NC(=O)N1CCN(C(c2ccccc2)c2ccccc2)CC1)C(=O)O | 10.1016/j.bmcl.2007.04.022 | |||
CHEMBL228900 | 92492 | 0 | None | - | 0 | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 452 | 9 | 5 | 4 | 1.8 | N=C(N)NCCC[C@@H](NC(=O)N1CCN(C(c2ccccc2)c2ccccc2)CC1)C(=O)O | 10.1016/j.bmcl.2007.04.022 | |||
136110893 | 214294 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 476 | 10 | 1 | 4 | 4.5 | CN(C)CCOc1ccc2c(c1)/C(=N/CCc1ccc(F)cc1)N=C2NCCc1ccc(F)cc1 | 10.1016/s0960-894x(01)00522-4 | |||
CHEMBL94544 | 214294 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 476 | 10 | 1 | 4 | 4.5 | CN(C)CCOc1ccc2c(c1)/C(=N/CCc1ccc(F)cc1)N=C2NCCc1ccc(F)cc1 | 10.1016/s0960-894x(01)00522-4 | |||
101886249 | 121745 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 436 | 10 | 5 | 6 | 1.7 | N=C(N)NCCC[C@H](NC(=O)c1noc(C(c2ccccc2)c2ccccc2)n1)C(=O)O | 10.1021/jm500956p | |||
CHEMBL3342681 | 121745 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 436 | 10 | 5 | 6 | 1.7 | N=C(N)NCCC[C@H](NC(=O)c1noc(C(c2ccccc2)c2ccccc2)n1)C(=O)O | 10.1021/jm500956p | |||
71565510 | 143171 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 566 | 14 | 6 | 7 | 3.3 | CC[C@H](C)[C@H](NC(=O)C(C)c1ccc2cc(OC)ccc2c1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
CHEMBL3735240 | 143171 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 566 | 14 | 6 | 7 | 3.3 | CC[C@H](C)[C@H](NC(=O)C(C)c1ccc2cc(OC)ccc2c1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
71565582 | 143232 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 550 | 14 | 6 | 7 | 3.4 | CC[C@H](C)[C@H](NC(=O)c1ccccc1Oc1ccccc1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
CHEMBL3735764 | 143232 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 550 | 14 | 6 | 7 | 3.4 | CC[C@H](C)[C@H](NC(=O)c1ccccc1Oc1ccccc1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
3529 | 10290 | 9 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 412 | 12 | 4 | 4 | 1.5 | O=C(N[C@H](C(=O)O)CCCN=C(N)N)COCC(c1ccccc1)c1ccccc1 | 10.1021/acs.jmedchem.9b00927 | |||
5311120 | 10290 | 9 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 412 | 12 | 4 | 4 | 1.5 | O=C(N[C@H](C(=O)O)CCCN=C(N)N)COCC(c1ccccc1)c1ccccc1 | 10.1021/acs.jmedchem.9b00927 | |||
CHEMBL389348 | 10290 | 9 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 412 | 12 | 4 | 4 | 1.5 | O=C(N[C@H](C(=O)O)CCCN=C(N)N)COCC(c1ccccc1)c1ccccc1 | 10.1021/acs.jmedchem.9b00927 | |||
17753143 | 92715 | 4 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 434 | 10 | 5 | 4 | 2.9 | N=C(N)NCCC[C@H](NC(=O)c1ccc(C(c2ccccc2)c2ccccc2)o1)C(=O)O | 10.1021/jm500956p | |||
CHEMBL230034 | 92715 | 4 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 434 | 10 | 5 | 4 | 2.9 | N=C(N)NCCC[C@H](NC(=O)c1ccc(C(c2ccccc2)c2ccccc2)o1)C(=O)O | 10.1021/jm500956p | |||
71565510 | 143171 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 566 | 14 | 6 | 7 | 3.3 | CC[C@H](C)[C@H](NC(=O)C(C)c1ccc2cc(OC)ccc2c1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
CHEMBL3735240 | 143171 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 566 | 14 | 6 | 7 | 3.3 | CC[C@H](C)[C@H](NC(=O)C(C)c1ccc2cc(OC)ccc2c1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
71565582 | 143232 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 550 | 14 | 6 | 7 | 3.4 | CC[C@H](C)[C@H](NC(=O)c1ccccc1Oc1ccccc1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
CHEMBL3735764 | 143232 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 550 | 14 | 6 | 7 | 3.4 | CC[C@H](C)[C@H](NC(=O)c1ccccc1Oc1ccccc1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
CHEMBL1170030 | 215322 | 11 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm1003705 | |||||
136110892 | 214744 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 449 | 6 | 1 | 2 | 6.7 | CC(C/N=C1\N=C(NCC(C)c2ccc(Cl)cc2)c2ccccc21)c1ccc(Cl)cc1 | 10.1016/s0960-894x(01)00522-4 | |||
CHEMBL97134 | 214744 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 449 | 6 | 1 | 2 | 6.7 | CC(C/N=C1\N=C(NCC(C)c2ccc(Cl)cc2)c2ccccc21)c1ccc(Cl)cc1 | 10.1016/s0960-894x(01)00522-4 | |||
136110887 | 214308 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 447 | 9 | 1 | 3 | 5.3 | CCCOc1ccc2c(c1)/C(=N/CCc1ccc(F)cc1)N=C2NCCc1ccc(F)cc1 | 10.1016/s0960-894x(01)00522-4 | |||
CHEMBL94618 | 214308 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 447 | 9 | 1 | 3 | 5.3 | CCCOc1ccc2c(c1)/C(=N/CCc1ccc(F)cc1)N=C2NCCc1ccc(F)cc1 | 10.1016/s0960-894x(01)00522-4 | |||
101886248 | 121752 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 434 | 10 | 6 | 4 | 2.0 | N=C(N)NCCC[C@H](NC(=O)c1c[nH]c(C(c2ccccc2)c2ccccc2)n1)C(=O)O | 10.1021/jm500956p | |||
CHEMBL3342688 | 121752 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 434 | 10 | 6 | 4 | 2.0 | N=C(N)NCCC[C@H](NC(=O)c1c[nH]c(C(c2ccccc2)c2ccccc2)n1)C(=O)O | 10.1021/jm500956p | |||
136110891 | 214148 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 381 | 6 | 1 | 2 | 4.9 | Cc1ccc(CC/N=C2\N=C(NCCc3ccc(C)cc3)c3ccccc32)cc1 | 10.1016/s0960-894x(01)00522-4 | |||
CHEMBL93713 | 214148 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 381 | 6 | 1 | 2 | 4.9 | Cc1ccc(CC/N=C2\N=C(NCCc3ccc(C)cc3)c3ccccc32)cc1 | 10.1016/s0960-894x(01)00522-4 | |||
17753143 | 92715 | 4 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 434 | 10 | 5 | 4 | 2.9 | N=C(N)NCCC[C@H](NC(=O)c1ccc(C(c2ccccc2)c2ccccc2)o1)C(=O)O | 10.1016/j.bmcl.2007.04.022 | |||
CHEMBL230034 | 92715 | 4 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 434 | 10 | 5 | 4 | 2.9 | N=C(N)NCCC[C@H](NC(=O)c1ccc(C(c2ccccc2)c2ccccc2)o1)C(=O)O | 10.1016/j.bmcl.2007.04.022 | |||
44430527 | 94029 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 469 | 7 | 1 | 3 | 4.7 | O=C(NC1CCN(C(=O)CCc2cccnc2)CC1)C(c1ccccc1)C1CCC(F)(F)CC1 | 10.1016/j.bmcl.2007.04.023 | |||
CHEMBL233028 | 94029 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 469 | 7 | 1 | 3 | 4.7 | O=C(NC1CCN(C(=O)CCc2cccnc2)CC1)C(c1ccccc1)C1CCC(F)(F)CC1 | 10.1016/j.bmcl.2007.04.023 | |||
44430539 | 94694 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 463 | 8 | 1 | 4 | 4.5 | COc1ccc(C(C(=O)NC2CCN(C(=O)CCc3cccnc3)CC2)C2CCCCC2)cc1 | 10.1016/j.bmcl.2007.04.023 | |||
CHEMBL233879 | 94694 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 463 | 8 | 1 | 4 | 4.5 | COc1ccc(C(C(=O)NC2CCN(C(=O)CCc3cccnc3)CC2)C2CCCCC2)cc1 | 10.1016/j.bmcl.2007.04.023 | |||
CHEMBL1170031 | 215323 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm1003705 | |||||
CHEMBL1170030 | 215322 | 11 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm1003705 | |||||
CHEMBL1170031 | 215323 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm1003705 | |||||
44426475 | 151447 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 394 | 8 | 5 | 4 | 2.5 | N=C(N)NCCC[C@@H](NC(=O)c1ccc(-c2cccc(Cl)c2)s1)C(=O)O | 10.1016/j.bmcl.2007.04.022 | |||
CHEMBL390834 | 151447 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 394 | 8 | 5 | 4 | 2.5 | N=C(N)NCCC[C@@H](NC(=O)c1ccc(-c2cccc(Cl)c2)s1)C(=O)O | 10.1016/j.bmcl.2007.04.022 | |||
44430528 | 94030 | 0 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 489 | 7 | 1 | 3 | 5.8 | CC1(C)CC(C(C(=O)NC2CCN(C(=O)CCc3cccnc3)CC2)c2ccccc2)CC(C)(C)C1 | 10.1016/j.bmcl.2007.04.023 | |||
CHEMBL233029 | 94030 | 0 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 489 | 7 | 1 | 3 | 5.8 | CC1(C)CC(C(C(=O)NC2CCN(C(=O)CCc3cccnc3)CC2)c2ccccc2)CC(C)(C)C1 | 10.1016/j.bmcl.2007.04.023 | |||
101886248 | 121752 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 434 | 10 | 6 | 4 | 2.0 | N=C(N)NCCC[C@H](NC(=O)c1c[nH]c(C(c2ccccc2)c2ccccc2)n1)C(=O)O | 10.1021/jm500956p | |||
CHEMBL3342688 | 121752 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 434 | 10 | 6 | 4 | 2.0 | N=C(N)NCCC[C@H](NC(=O)c1c[nH]c(C(c2ccccc2)c2ccccc2)n1)C(=O)O | 10.1021/jm500956p | |||
10595 | 8934 | 21 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 532 | 10 | 5 | 4 | 5.0 | O=C(c1sc(cc1C)C(c1ccc(cc1)Cl)c1ccc(cc1)Cl)N[C@H](C(=O)O)CCCNC(=N)N | 10.1021/acs.jmedchem.9b00927 | |||
145996525 | 8934 | 21 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 532 | 10 | 5 | 4 | 5.0 | O=C(c1sc(cc1C)C(c1ccc(cc1)Cl)c1ccc(cc1)Cl)N[C@H](C(=O)O)CCCNC(=N)N | 10.1021/acs.jmedchem.9b00927 | |||
CHEMBL4459627 | 8934 | 21 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 532 | 10 | 5 | 4 | 5.0 | O=C(c1sc(cc1C)C(c1ccc(cc1)Cl)c1ccc(cc1)Cl)N[C@H](C(=O)O)CCCNC(=N)N | 10.1021/acs.jmedchem.9b00927 | |||
8384 | 7897 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 428 | 12 | 5 | 4 | 2.4 | NC(=N)NCCC[C@@H](C(=O)O)NC(=O)CSCC(c1ccccc1)c1ccccc1 | 10.1021/jm500956p | |||
91827355 | 7897 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 428 | 12 | 5 | 4 | 2.4 | NC(=N)NCCC[C@@H](C(=O)O)NC(=O)CSCC(c1ccccc1)c1ccccc1 | 10.1021/jm500956p | |||
CHEMBL3342676 | 7897 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 428 | 12 | 5 | 4 | 2.4 | NC(=N)NCCC[C@@H](C(=O)O)NC(=O)CSCC(c1ccccc1)c1ccccc1 | 10.1021/jm500956p | |||
117634949 | 143228 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 518 | 14 | 6 | 8 | 1.7 | CC[C@H](C)[C@H](NC(=O)c1cccc(OC)c1OC)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
CHEMBL3735746 | 143228 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 518 | 14 | 6 | 8 | 1.7 | CC[C@H](C)[C@H](NC(=O)c1cccc(OC)c1OC)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
117634949 | 143228 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 518 | 14 | 6 | 8 | 1.7 | CC[C@H](C)[C@H](NC(=O)c1cccc(OC)c1OC)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
CHEMBL3735746 | 143228 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 518 | 14 | 6 | 8 | 1.7 | CC[C@H](C)[C@H](NC(=O)c1cccc(OC)c1OC)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
136110889 | 112977 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 421 | 6 | 1 | 2 | 5.6 | Clc1ccc(CC/N=C2\N=C(NCCc3ccc(Cl)cc3)c3ccccc32)cc1 | 10.1016/s0960-894x(01)00522-4 | |||
CHEMBL313866 | 112977 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 421 | 6 | 1 | 2 | 5.6 | Clc1ccc(CC/N=C2\N=C(NCCc3ccc(Cl)cc3)c3ccccc32)cc1 | 10.1016/s0960-894x(01)00522-4 | |||
CHEMBL1170027 | 215319 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CC(=O)O)N(C)C(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/jm1003705 | |||||
136110897 | 214788 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 421 | 6 | 1 | 2 | 5.6 | Clc1cccc(CC/N=C2\N=C(NCCc3cccc(Cl)c3)c3ccccc32)c1 | 10.1016/s0960-894x(01)00522-4 | |||
CHEMBL97335 | 214788 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 421 | 6 | 1 | 2 | 5.6 | Clc1cccc(CC/N=C2\N=C(NCCc3cccc(Cl)c3)c3ccccc32)c1 | 10.1016/s0960-894x(01)00522-4 | |||
117634979 | 143133 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 502 | 13 | 6 | 6 | 2.5 | CC[C@H](C)[C@H](NC(=O)C1(C(C)C)C=CCC=C1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
CHEMBL3734832 | 143133 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 502 | 13 | 6 | 6 | 2.5 | CC[C@H](C)[C@H](NC(=O)C1(C(C)C)C=CCC=C1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
117634979 | 143133 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 502 | 13 | 6 | 6 | 2.5 | CC[C@H](C)[C@H](NC(=O)C1(C(C)C)C=CCC=C1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
CHEMBL3734832 | 143133 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 502 | 13 | 6 | 6 | 2.5 | CC[C@H](C)[C@H](NC(=O)C1(C(C)C)C=CCC=C1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
89570463 | 121751 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 510 | 11 | 6 | 4 | 3.7 | N=C(N)NCCC[C@H](NC(=O)c1nc(C(c2ccccc2)c2ccccc2)[nH]c1-c1ccccc1)C(=O)O | 10.1021/jm500956p | |||
CHEMBL3342687 | 121751 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 510 | 11 | 6 | 4 | 3.7 | N=C(N)NCCC[C@H](NC(=O)c1nc(C(c2ccccc2)c2ccccc2)[nH]c1-c1ccccc1)C(=O)O | 10.1021/jm500956p | |||
17753265 | 93530 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 447 | 7 | 1 | 3 | 4.8 | Cc1cccc(C(C(=O)NC2CCN(C(=O)CCc3cccnc3)CC2)C2CCCCC2)c1 | 10.1016/j.bmcl.2007.04.023 | |||
CHEMBL232031 | 93530 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 447 | 7 | 1 | 3 | 4.8 | Cc1cccc(C(C(=O)NC2CCN(C(=O)CCc3cccnc3)CC2)C2CCCCC2)c1 | 10.1016/j.bmcl.2007.04.023 | |||
44426463 | 93169 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 378 | 8 | 5 | 4 | 2.0 | N=C(N)NCCC[C@@H](NC(=O)c1ccc(-c2cccc(Cl)c2)o1)C(=O)O | 10.1016/j.bmcl.2007.04.022 | |||
CHEMBL231405 | 93169 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 378 | 8 | 5 | 4 | 2.0 | N=C(N)NCCC[C@@H](NC(=O)c1ccc(-c2cccc(Cl)c2)o1)C(=O)O | 10.1016/j.bmcl.2007.04.022 | |||
CHEMBL1170027 | 215319 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CC(=O)O)N(C)C(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/jm1003705 | |||||
71565508 | 143274 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 501 | 13 | 6 | 7 | 1.7 | CC[C@H](C)[C@H](NC(=O)c1ccc(N(C)C)cc1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
CHEMBL3736195 | 143274 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 501 | 13 | 6 | 7 | 1.7 | CC[C@H](C)[C@H](NC(=O)c1ccc(N(C)C)cc1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
11252 | 7557 | 39 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 433 | 7 | 1 | 3 | 4.5 | O=C(N1CCC(CC1)NC(=O)C(c1ccccc1)C1CCCCC1)CCc1cccnc1 | 10.1016/j.bmcl.2007.04.023 | |||
44430519 | 7557 | 39 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 433 | 7 | 1 | 3 | 4.5 | O=C(N1CCC(CC1)NC(=O)C(c1ccccc1)C1CCCCC1)CCc1cccnc1 | 10.1016/j.bmcl.2007.04.023 | |||
CHEMBL390036 | 7557 | 39 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 433 | 7 | 1 | 3 | 4.5 | O=C(N1CCC(CC1)NC(=O)C(c1ccccc1)C1CCCCC1)CCc1cccnc1 | 10.1016/j.bmcl.2007.04.023 | |||
44430530 | 94103 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 447 | 8 | 1 | 3 | 4.9 | O=C(NC1CCN(C(=O)CCc2cccnc2)CC1)C(CC1CCCCC1)c1ccccc1 | 10.1016/j.bmcl.2007.04.023 | |||
CHEMBL233233 | 94103 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 447 | 8 | 1 | 3 | 4.9 | O=C(NC1CCN(C(=O)CCc2cccnc2)CC1)C(CC1CCCCC1)c1ccccc1 | 10.1016/j.bmcl.2007.04.023 | |||
44430551 | 94779 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 483 | 7 | 1 | 3 | 5.6 | O=C(NC1CCN(C(=O)CCc2cccnc2)CC1)C(c1ccc2ccccc2c1)C1CCCCC1 | 10.1016/j.bmcl.2007.04.023 | |||
CHEMBL234305 | 94779 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 483 | 7 | 1 | 3 | 5.6 | O=C(NC1CCN(C(=O)CCc2cccnc2)CC1)C(c1ccc2ccccc2c1)C1CCCCC1 | 10.1016/j.bmcl.2007.04.023 | |||
44430533 | 148878 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 447 | 7 | 1 | 3 | 4.8 | Cc1ccc(C(C(=O)NC2CCN(C(=O)CCc3cccnc3)CC2)C2CCCCC2)cc1 | 10.1016/j.bmcl.2007.04.023 | |||
CHEMBL388204 | 148878 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 447 | 7 | 1 | 3 | 4.8 | Cc1ccc(C(C(=O)NC2CCN(C(=O)CCc3cccnc3)CC2)C2CCCCC2)cc1 | 10.1016/j.bmcl.2007.04.023 | |||
44430531 | 159372 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 419 | 7 | 1 | 3 | 4.1 | O=C(NC1CCN(C(=O)CCc2cccnc2)CC1)C(c1ccccc1)C1CCCC1 | 10.1016/j.bmcl.2007.04.023 | |||
CHEMBL397190 | 159372 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 419 | 7 | 1 | 3 | 4.1 | O=C(NC1CCN(C(=O)CCc2cccnc2)CC1)C(c1ccccc1)C1CCCC1 | 10.1016/j.bmcl.2007.04.023 | |||
44426465 | 92447 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 392 | 8 | 5 | 4 | 2.4 | Cc1ccc(Cl)cc1-c1ccc(C(=O)N[C@H](CCCNC(=N)N)C(=O)O)o1 | 10.1016/j.bmcl.2007.04.022 | |||
CHEMBL228582 | 92447 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 392 | 8 | 5 | 4 | 2.4 | Cc1ccc(Cl)cc1-c1ccc(C(=O)N[C@H](CCCNC(=N)N)C(=O)O)o1 | 10.1016/j.bmcl.2007.04.022 | |||
44426472 | 92479 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 388 | 8 | 5 | 3 | 2.5 | N=C(N)NCCC[C@@H](NC(=O)c1cccc(-c2cccc(Cl)c2)c1)C(=O)O | 10.1016/j.bmcl.2007.04.022 | |||
CHEMBL228847 | 92479 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 388 | 8 | 5 | 3 | 2.5 | N=C(N)NCCC[C@@H](NC(=O)c1cccc(-c2cccc(Cl)c2)c1)C(=O)O | 10.1016/j.bmcl.2007.04.022 | |||
44426481 | 92493 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 444 | 10 | 5 | 3 | 3.3 | N=C(N)NCCC[C@@H](NC(=O)c1ccc(C(c2ccccc2)c2ccccc2)cc1)C(=O)O | 10.1016/j.bmcl.2007.04.022 | |||
CHEMBL228901 | 92493 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 444 | 10 | 5 | 3 | 3.3 | N=C(N)NCCC[C@@H](NC(=O)c1ccc(C(c2ccccc2)c2ccccc2)cc1)C(=O)O | 10.1016/j.bmcl.2007.04.022 | |||
44426461 | 156154 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 374 | 9 | 6 | 5 | 0.9 | N=C(N)NCCC[C@@H](NC(=O)c1ccc(-c2cccc(CO)c2)o1)C(=O)O | 10.1016/j.bmcl.2007.04.022 | |||
CHEMBL394539 | 156154 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 374 | 9 | 6 | 5 | 0.9 | N=C(N)NCCC[C@@H](NC(=O)c1ccc(-c2cccc(CO)c2)o1)C(=O)O | 10.1016/j.bmcl.2007.04.022 | |||
CHEMBL1170646 | 215354 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm1003705 | |||||
44430513 | 99137 | 0 | None | - | 0 | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 439 | 5 | 1 | 3 | 3.9 | O=C(NC1CCN(C(=O)CCc2cccnc2)CC1)C1c2ccccc2Cc2ccccc21 | 10.1016/j.bmcl.2007.04.023 | |||
CHEMBL243048 | 99137 | 0 | None | - | 0 | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 439 | 5 | 1 | 3 | 3.9 | O=C(NC1CCN(C(=O)CCc2cccnc2)CC1)C1c2ccccc2Cc2ccccc21 | 10.1016/j.bmcl.2007.04.023 | |||
10595 | 8934 | 21 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 532 | 10 | 5 | 4 | 5.0 | O=C(c1sc(cc1C)C(c1ccc(cc1)Cl)c1ccc(cc1)Cl)N[C@H](C(=O)O)CCCNC(=N)N | 10.1021/acs.jmedchem.9b00927 | |||
145996525 | 8934 | 21 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 532 | 10 | 5 | 4 | 5.0 | O=C(c1sc(cc1C)C(c1ccc(cc1)Cl)c1ccc(cc1)Cl)N[C@H](C(=O)O)CCCNC(=N)N | 10.1021/acs.jmedchem.9b00927 | |||
CHEMBL4459627 | 8934 | 21 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 532 | 10 | 5 | 4 | 5.0 | O=C(c1sc(cc1C)C(c1ccc(cc1)Cl)c1ccc(cc1)Cl)N[C@H](C(=O)O)CCCNC(=N)N | 10.1021/acs.jmedchem.9b00927 | |||
8384 | 7897 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 428 | 12 | 5 | 4 | 2.4 | NC(=N)NCCC[C@@H](C(=O)O)NC(=O)CSCC(c1ccccc1)c1ccccc1 | 10.1021/jm500956p | |||
91827355 | 7897 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 428 | 12 | 5 | 4 | 2.4 | NC(=N)NCCC[C@@H](C(=O)O)NC(=O)CSCC(c1ccccc1)c1ccccc1 | 10.1021/jm500956p | |||
CHEMBL3342676 | 7897 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 428 | 12 | 5 | 4 | 2.4 | NC(=N)NCCC[C@@H](C(=O)O)NC(=O)CSCC(c1ccccc1)c1ccccc1 | 10.1021/jm500956p | |||
71565508 | 143274 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 501 | 13 | 6 | 7 | 1.7 | CC[C@H](C)[C@H](NC(=O)c1ccc(N(C)C)cc1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
CHEMBL3736195 | 143274 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 501 | 13 | 6 | 7 | 1.7 | CC[C@H](C)[C@H](NC(=O)c1ccc(N(C)C)cc1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
CHEMBL1170637 | 215347 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm1003705 | |||||
CHEMBL1170637 | 215347 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm1003705 | |||||
CHEMBL1170646 | 215354 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm1003705 | |||||
136110888 | 214639 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 325 | 4 | 1 | 2 | 4.1 | CC(C)NC1=N/C(=N\CCc2ccc(Cl)cc2)c2ccccc21 | 10.1016/s0960-894x(01)00522-4 | |||
CHEMBL96477 | 214639 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 325 | 4 | 1 | 2 | 4.1 | CC(C)NC1=N/C(=N\CCc2ccc(Cl)cc2)c2ccccc21 | 10.1016/s0960-894x(01)00522-4 | |||
89570463 | 121751 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 510 | 11 | 6 | 4 | 3.7 | N=C(N)NCCC[C@H](NC(=O)c1nc(C(c2ccccc2)c2ccccc2)[nH]c1-c1ccccc1)C(=O)O | 10.1021/jm500956p | |||
CHEMBL3342687 | 121751 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 510 | 11 | 6 | 4 | 3.7 | N=C(N)NCCC[C@H](NC(=O)c1nc(C(c2ccccc2)c2ccccc2)[nH]c1-c1ccccc1)C(=O)O | 10.1021/jm500956p | |||
117637102 | 143308 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 518 | 14 | 6 | 8 | 1.7 | CC[C@H](C)[C@H](NC(=O)c1ccc(OC)cc1OC)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
CHEMBL3736447 | 143308 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 518 | 14 | 6 | 8 | 1.7 | CC[C@H](C)[C@H](NC(=O)c1ccc(OC)cc1OC)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
117637102 | 143308 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 518 | 14 | 6 | 8 | 1.7 | CC[C@H](C)[C@H](NC(=O)c1ccc(OC)cc1OC)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
CHEMBL3736447 | 143308 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 518 | 14 | 6 | 8 | 1.7 | CC[C@H](C)[C@H](NC(=O)c1ccc(OC)cc1OC)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | 10.1016/j.bmcl.2015.10.038 | |||
71566654 | 7792 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 497 | 12 | 6 | 6 | 1.9 | CC(C[C@@H](c1occ(n1)C(=O)N[C@H](C(=O)O)CCCN=C(N)N)NC(=O)c1c[nH]c2c1cccc2)C | 10.1016/j.bmcl.2015.10.038 | |||
9449 | 7792 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 497 | 12 | 6 | 6 | 1.9 | CC(C[C@@H](c1occ(n1)C(=O)N[C@H](C(=O)O)CCCN=C(N)N)NC(=O)c1c[nH]c2c1cccc2)C | 10.1016/j.bmcl.2015.10.038 | |||
CHEMBL3736108 | 7792 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 497 | 12 | 6 | 6 | 1.9 | CC(C[C@@H](c1occ(n1)C(=O)N[C@H](C(=O)O)CCCN=C(N)N)NC(=O)c1c[nH]c2c1cccc2)C | 10.1016/j.bmcl.2015.10.038 | |||
71566654 | 7792 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 497 | 12 | 6 | 6 | 1.9 | CC(C[C@@H](c1occ(n1)C(=O)N[C@H](C(=O)O)CCCN=C(N)N)NC(=O)c1c[nH]c2c1cccc2)C | 10.1016/j.bmcl.2015.10.038 | |||
9449 | 7792 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 497 | 12 | 6 | 6 | 1.9 | CC(C[C@@H](c1occ(n1)C(=O)N[C@H](C(=O)O)CCCN=C(N)N)NC(=O)c1c[nH]c2c1cccc2)C | 10.1016/j.bmcl.2015.10.038 | |||
CHEMBL3736108 | 7792 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 497 | 12 | 6 | 6 | 1.9 | CC(C[C@@H](c1occ(n1)C(=O)N[C@H](C(=O)O)CCCN=C(N)N)NC(=O)c1c[nH]c2c1cccc2)C | 10.1016/j.bmcl.2015.10.038 | |||
118716617 | 121741 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 410 | 12 | 5 | 3 | 2.8 | N=C(N)NCCC[C@H](NC(=O)CCCC(c1ccccc1)c1ccccc1)C(=O)O | 10.1021/jm500956p | |||
CHEMBL3342677 | 121741 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 410 | 12 | 5 | 3 | 2.8 | N=C(N)NCCC[C@H](NC(=O)CCCC(c1ccccc1)c1ccccc1)C(=O)O | 10.1021/jm500956p | |||
117634981 | 121746 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 436 | 10 | 5 | 6 | 1.7 | N=C(N)NCCC[C@H](NC(=O)c1nnc(C(c2ccccc2)c2ccccc2)o1)C(=O)O | 10.1021/jm500956p | |||
CHEMBL3342682 | 121746 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 436 | 10 | 5 | 6 | 1.7 | N=C(N)NCCC[C@H](NC(=O)c1nnc(C(c2ccccc2)c2ccccc2)o1)C(=O)O | 10.1021/jm500956p | |||
11252 | 7557 | 39 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | Guide to Pharmacology | 433 | 7 | 1 | 3 | 4.5 | O=C(N1CCC(CC1)NC(=O)C(c1ccccc1)C1CCCCC1)CCc1cccnc1 | 17459702 | |||
44430519 | 7557 | 39 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | Guide to Pharmacology | 433 | 7 | 1 | 3 | 4.5 | O=C(N1CCC(CC1)NC(=O)C(c1ccccc1)C1CCCCC1)CCc1cccnc1 | 17459702 | |||
CHEMBL390036 | 7557 | 39 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | Guide to Pharmacology | 433 | 7 | 1 | 3 | 4.5 | O=C(N1CCC(CC1)NC(=O)C(c1ccccc1)C1CCCCC1)CCc1cccnc1 | 17459702 | |||
11286 | 8378 | 0 | None | - | 1 | Human | 8.1 | pKd | = | 8.1 | Binding | Guide to Pharmacology | None | None | None | None | 28562031 |