Ligand source activities (1 row/activity)
Ligands (move mouse cursor over ligand name to see structure) | Receptor | Assay information | Chemical information | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name |
GPCRdb ID |
#Vendors |
Reference ligand |
Fold selectivity |
# Tested GPCRs |
Species |
p-value (-log) |
Activity Type |
Activity Relation |
Activity Value |
AssayType |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
57401968 | 76320 | 0 | None | - | 1 | Human | 10.0 | pIC50 | = | 10 | Functional | ChEMBL | 451 | 4 | 1 | 3 | 5.9 | CCn1c2ccccc2c2cc(CN3CCC4(CC3)CC(NC(C)=O)c3ccccc34)ccc21 | 10.1016/j.bmcl.2011.10.125 | ||
CHEMBL1934121 | 76320 | 0 | None | - | 1 | Human | 10.0 | pIC50 | = | 10 | Functional | ChEMBL | 451 | 4 | 1 | 3 | 5.9 | CCn1c2ccccc2c2cc(CN3CCC4(CC3)CC(NC(C)=O)c3ccccc34)ccc21 | 10.1016/j.bmcl.2011.10.125 | ||
10410064 | 76322 | 0 | None | - | 1 | Human | 10.0 | pIC50 | = | 10 | Functional | ChEMBL | 423 | 3 | 2 | 2 | 5.4 | CC(=O)N[C@@H]1CC2(CCN(Cc3ccc4[nH]c5ccccc5c4c3)CC2)c2ccccc21 | 10.1016/j.bmcl.2011.10.125 | ||
CHEMBL1934123 | 76322 | 0 | None | - | 1 | Human | 10.0 | pIC50 | = | 10 | Functional | ChEMBL | 423 | 3 | 2 | 2 | 5.4 | CC(=O)N[C@@H]1CC2(CCN(Cc3ccc4[nH]c5ccccc5c4c3)CC2)c2ccccc21 | 10.1016/j.bmcl.2011.10.125 | ||
57394992 | 76326 | 0 | None | 501 | 2 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 457 | 3 | 2 | 2 | 6.1 | CC(=O)N[C@@H]1CC2(CCN(Cc3ccc4[nH]c5ccc(Cl)cc5c4c3)CC2)c2ccccc21 | 10.1016/j.bmcl.2011.10.125 | ||
CHEMBL1934127 | 76326 | 0 | None | 501 | 2 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 457 | 3 | 2 | 2 | 6.1 | CC(=O)N[C@@H]1CC2(CCN(Cc3ccc4[nH]c5ccc(Cl)cc5c4c3)CC2)c2ccccc21 | 10.1016/j.bmcl.2011.10.125 | ||
10457264 | 76329 | 0 | None | 1513 | 2 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 466 | 3 | 2 | 4 | 4.8 | CC(=O)N[C@@H]1CC2(CCN(Cc3ccc4c(c3)c3ccccc3n4C(N)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2011.10.125 | ||
CHEMBL1934130 | 76329 | 0 | None | 1513 | 2 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 466 | 3 | 2 | 4 | 4.8 | CC(=O)N[C@@H]1CC2(CCN(Cc3ccc4c(c3)c3ccccc3n4C(N)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2011.10.125 | ||
10091316 | 76315 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 382 | 2 | 2 | 2 | 4.8 | O[C@@H]1Cc2ccccc2C12CCN(Cc1ccc3[nH]c4ccccc4c3c1)CC2 | 10.1016/j.bmcl.2011.10.125 | ||
CHEMBL1934116 | 76315 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 382 | 2 | 2 | 2 | 4.8 | O[C@@H]1Cc2ccccc2C12CCN(Cc1ccc3[nH]c4ccccc4c3c1)CC2 | 10.1016/j.bmcl.2011.10.125 | ||
57391501 | 76325 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 441 | 3 | 2 | 2 | 5.6 | CC(=O)N[C@@H]1CC2(CCN(Cc3ccc4[nH]c5ccc(F)cc5c4c3)CC2)c2ccccc21 | 10.1016/j.bmcl.2011.10.125 | ||
CHEMBL1934126 | 76325 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 441 | 3 | 2 | 2 | 5.6 | CC(=O)N[C@@H]1CC2(CCN(Cc3ccc4[nH]c5ccc(F)cc5c4c3)CC2)c2ccccc21 | 10.1016/j.bmcl.2011.10.125 | ||
57396735 | 76327 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 501 | 3 | 2 | 2 | 6.2 | CC(=O)N[C@@H]1CC2(CCN(Cc3ccc4[nH]c5ccc(Br)cc5c4c3)CC2)c2ccccc21 | 10.1016/j.bmcl.2011.10.125 | ||
CHEMBL1934128 | 76327 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 501 | 3 | 2 | 2 | 6.2 | CC(=O)N[C@@H]1CC2(CCN(Cc3ccc4[nH]c5ccc(Br)cc5c4c3)CC2)c2ccccc21 | 10.1016/j.bmcl.2011.10.125 | ||
10090198 | 76306 | 1 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 364 | 2 | 1 | 1 | 5.9 | C1=CC2(CCN(Cc3ccc4[nH]c5ccccc5c4c3)CC2)c2ccccc21 | 10.1016/j.bmcl.2011.10.125 | ||
CHEMBL1934107 | 76306 | 1 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 364 | 2 | 1 | 1 | 5.9 | C1=CC2(CCN(Cc3ccc4[nH]c5ccccc5c4c3)CC2)c2ccccc21 | 10.1016/j.bmcl.2011.10.125 | ||
10025150 | 76312 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 420 | 3 | 0 | 3 | 6.4 | CCC(=O)n1c2ccccc2c2cc(CN3CCC4(C=Cc5ccccc54)CC3)ccc21 | 10.1016/j.bmcl.2011.10.125 | ||
CHEMBL1934113 | 76312 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 420 | 3 | 0 | 3 | 6.4 | CCC(=O)n1c2ccccc2c2cc(CN3CCC4(C=Cc5ccccc54)CC3)ccc21 | 10.1016/j.bmcl.2011.10.125 | ||
57401967 | 76318 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 467 | 4 | 2 | 4 | 4.9 | CCn1c2ccccc2c2cc(CN3CCC4(CC3)c3ccccc3[C@H](NC(C)=O)[C@H]4O)ccc21 | 10.1016/j.bmcl.2011.10.125 | ||
CHEMBL1934119 | 76318 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 467 | 4 | 2 | 4 | 4.9 | CCn1c2ccccc2c2cc(CN3CCC4(CC3)c3ccccc3[C@H](NC(C)=O)[C@H]4O)ccc21 | 10.1016/j.bmcl.2011.10.125 | ||
30979231 | 76301 | 4 | None | 19 | 2 | Human | 6.0 | pIC50 | = | 6 | Functional | ChEMBL | 392 | 3 | 0 | 2 | 6.4 | CCn1c2ccccc2c2cc(CN3CCC4(C=Cc5ccccc54)CC3)ccc21 | 10.1016/j.bmcl.2011.10.125 | ||
CHEMBL1934102 | 76301 | 4 | None | 19 | 2 | Human | 6.0 | pIC50 | = | 6 | Functional | ChEMBL | 392 | 3 | 0 | 2 | 6.4 | CCn1c2ccccc2c2cc(CN3CCC4(C=Cc5ccccc54)CC3)ccc21 | 10.1016/j.bmcl.2011.10.125 | ||
57403720 | 76302 | 0 | None | - | 1 | Human | 5.0 | pIC50 | = | 5 | Functional | ChEMBL | 406 | 4 | 0 | 2 | 6.4 | CCn1c2ccccc2c2cc(CCN3CCC4(C=Cc5ccccc54)CC3)ccc21 | 10.1016/j.bmcl.2011.10.125 | ||
CHEMBL1934103 | 76302 | 0 | None | - | 1 | Human | 5.0 | pIC50 | = | 5 | Functional | ChEMBL | 406 | 4 | 0 | 2 | 6.4 | CCn1c2ccccc2c2cc(CCN3CCC4(C=Cc5ccccc54)CC3)ccc21 | 10.1016/j.bmcl.2011.10.125 | ||
57401969 | 76321 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 423 | 3 | 2 | 2 | 5.4 | CC(=O)N[C@H]1CC2(CCN(Cc3ccc4[nH]c5ccccc5c4c3)CC2)c2ccccc21 | 10.1016/j.bmcl.2011.10.125 | ||
CHEMBL1934122 | 76321 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 423 | 3 | 2 | 2 | 5.4 | CC(=O)N[C@H]1CC2(CCN(Cc3ccc4[nH]c5ccccc5c4c3)CC2)c2ccccc21 | 10.1016/j.bmcl.2011.10.125 | ||
57400179 | 76317 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 426 | 3 | 2 | 4 | 4.8 | CCn1c2ccccc2c2cc(CN3CCC4(CC3)c3ccccc3[C@H](O)[C@H]4O)ccc21 | 10.1016/j.bmcl.2011.10.125 | ||
CHEMBL1934118 | 76317 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 426 | 3 | 2 | 4 | 4.8 | CCn1c2ccccc2c2cc(CN3CCC4(CC3)c3ccccc3[C@H](O)[C@H]4O)ccc21 | 10.1016/j.bmcl.2011.10.125 | ||
57396733 | 76303 | 0 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 420 | 5 | 0 | 2 | 6.8 | CCn1c2ccccc2c2cc(CCCN3CCC4(C=Cc5ccccc54)CC3)ccc21 | 10.1016/j.bmcl.2011.10.125 | ||
CHEMBL1934104 | 76303 | 0 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 420 | 5 | 0 | 2 | 6.8 | CCn1c2ccccc2c2cc(CCCN3CCC4(C=Cc5ccccc54)CC3)ccc21 | 10.1016/j.bmcl.2011.10.125 | ||
57396734 | 76310 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 442 | 3 | 0 | 4 | 5.2 | CS(=O)(=O)n1c2ccccc2c2cc(CN3CCC4(C=Cc5ccccc54)CC3)ccc21 | 10.1016/j.bmcl.2011.10.125 | ||
CHEMBL1934111 | 76310 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 442 | 3 | 0 | 4 | 5.2 | CS(=O)(=O)n1c2ccccc2c2cc(CN3CCC4(C=Cc5ccccc54)CC3)ccc21 | 10.1016/j.bmcl.2011.10.125 | ||
57400177 | 76314 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 410 | 3 | 1 | 3 | 5.8 | CCn1c2ccccc2c2cc(CN3CCC4(CC3)CC(O)c3ccccc34)ccc21 | 10.1016/j.bmcl.2011.10.125 | ||
CHEMBL1934115 | 76314 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 410 | 3 | 1 | 3 | 5.8 | CCn1c2ccccc2c2cc(CN3CCC4(CC3)CC(O)c3ccccc34)ccc21 | 10.1016/j.bmcl.2011.10.125 | ||
57394991 | 76319 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 451 | 4 | 1 | 3 | 5.4 | CCn1c2ccccc2c2cc(CN3CCC4(CC3)c3ccccc3CC4NC(C)=O)ccc21 | 10.1016/j.bmcl.2011.10.125 | ||
CHEMBL1934120 | 76319 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 451 | 4 | 1 | 3 | 5.4 | CCn1c2ccccc2c2cc(CN3CCC4(CC3)c3ccccc3CC4NC(C)=O)ccc21 | 10.1016/j.bmcl.2011.10.125 | ||
57403723 | 76323 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 426 | 3 | 2 | 4 | 4.8 | CCn1c2ccccc2c2cc(CN3CCC4(CC3)c3ccccc3[C@H](O)[C@@H]4O)ccc21 | 10.1016/j.bmcl.2011.10.125 | ||
CHEMBL1934124 | 76323 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 426 | 3 | 2 | 4 | 4.8 | CCn1c2ccccc2c2cc(CN3CCC4(CC3)c3ccccc3[C@H](O)[C@@H]4O)ccc21 | 10.1016/j.bmcl.2011.10.125 | ||
23572819 | 76313 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 410 | 3 | 1 | 3 | 5.3 | CCn1c2ccccc2c2cc(CN3CCC4(CC3)c3ccccc3CC4O)ccc21 | 10.1016/j.bmcl.2011.10.125 | ||
CHEMBL1934114 | 76313 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 410 | 3 | 1 | 3 | 5.3 | CCn1c2ccccc2c2cc(CN3CCC4(CC3)c3ccccc3CC4O)ccc21 | 10.1016/j.bmcl.2011.10.125 | ||
57400176 | 76309 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 422 | 2 | 0 | 4 | 6.0 | COC(=O)n1c2ccccc2c2cc(CN3CCC4(C=Cc5ccccc54)CC3)ccc21 | 10.1016/j.bmcl.2011.10.125 | ||
CHEMBL1934110 | 76309 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 422 | 2 | 0 | 4 | 6.0 | COC(=O)n1c2ccccc2c2cc(CN3CCC4(C=Cc5ccccc54)CC3)ccc21 | 10.1016/j.bmcl.2011.10.125 | ||
10455647 | 76308 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 435 | 2 | 0 | 3 | 5.9 | CN(C)C(=O)n1c2ccccc2c2cc(CN3CCC4(C=Cc5ccccc54)CC3)ccc21 | 10.1016/j.bmcl.2011.10.125 | ||
CHEMBL1934109 | 76308 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 435 | 2 | 0 | 3 | 5.9 | CN(C)C(=O)n1c2ccccc2c2cc(CN3CCC4(C=Cc5ccccc54)CC3)ccc21 | 10.1016/j.bmcl.2011.10.125 | ||
10046992 | 76311 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 407 | 2 | 1 | 3 | 5.3 | NC(=O)n1c2ccccc2c2cc(CN3CCC4(C=Cc5ccccc54)CC3)ccc21 | 10.1016/j.bmcl.2011.10.125 | ||
CHEMBL1934112 | 76311 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 407 | 2 | 1 | 3 | 5.3 | NC(=O)n1c2ccccc2c2cc(CN3CCC4(C=Cc5ccccc54)CC3)ccc21 | 10.1016/j.bmcl.2011.10.125 | ||
57403721 | 76304 | 0 | None | - | 1 | Human | 4.2 | pIC50 | = | 4.2 | Functional | ChEMBL | 406 | 2 | 0 | 2 | 6.0 | CCn1c2ccccc2c2cc(C(=O)N3CCC4(C=Cc5ccccc54)CC3)ccc21 | 10.1016/j.bmcl.2011.10.125 | ||
CHEMBL1934105 | 76304 | 0 | None | - | 1 | Human | 4.2 | pIC50 | = | 4.2 | Functional | ChEMBL | 406 | 2 | 0 | 2 | 6.0 | CCn1c2ccccc2c2cc(C(=O)N3CCC4(C=Cc5ccccc54)CC3)ccc21 | 10.1016/j.bmcl.2011.10.125 | ||
57401966 | 76305 | 0 | None | - | 1 | Human | 4.2 | pIC50 | = | 4.2 | Functional | ChEMBL | 421 | 2 | 1 | 2 | 6.4 | CCn1c2ccccc2c2cc(NC(=O)N3CCC4(C=Cc5ccccc54)CC3)ccc21 | 10.1016/j.bmcl.2011.10.125 | ||
CHEMBL1934106 | 76305 | 0 | None | - | 1 | Human | 4.2 | pIC50 | = | 4.2 | Functional | ChEMBL | 421 | 2 | 1 | 2 | 6.4 | CCn1c2ccccc2c2cc(NC(=O)N3CCC4(C=Cc5ccccc54)CC3)ccc21 | 10.1016/j.bmcl.2011.10.125 | ||
57391502 | 76328 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 491 | 3 | 2 | 2 | 6.5 | CC(=O)N[C@@H]1CC2(CCN(Cc3ccc4[nH]c5ccc(C(F)(F)F)cc5c4c3)CC2)c2ccccc21 | 10.1016/j.bmcl.2011.10.125 | ||
CHEMBL1934129 | 76328 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 491 | 3 | 2 | 2 | 6.5 | CC(=O)N[C@@H]1CC2(CCN(Cc3ccc4[nH]c5ccc(C(F)(F)F)cc5c4c3)CC2)c2ccccc21 | 10.1016/j.bmcl.2011.10.125 | ||
57403722 | 76307 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 406 | 2 | 0 | 3 | 6.0 | CC(=O)n1c2ccccc2c2cc(CN3CCC4(C=Cc5ccccc54)CC3)ccc21 | 10.1016/j.bmcl.2011.10.125 | ||
CHEMBL1934108 | 76307 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 406 | 2 | 0 | 3 | 6.0 | CC(=O)n1c2ccccc2c2cc(CN3CCC4(C=Cc5ccccc54)CC3)ccc21 | 10.1016/j.bmcl.2011.10.125 | ||
57400180 | 76324 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 439 | 3 | 3 | 3 | 4.4 | CC(=O)N[C@H]1c2ccccc2C2(CCN(Cc3ccc4[nH]c5ccccc5c4c3)CC2)[C@@H]1O | 10.1016/j.bmcl.2011.10.125 | ||
CHEMBL1934125 | 76324 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 439 | 3 | 3 | 3 | 4.4 | CC(=O)N[C@H]1c2ccccc2C2(CCN(Cc3ccc4[nH]c5ccccc5c4c3)CC2)[C@@H]1O | 10.1016/j.bmcl.2011.10.125 | ||
57400178 | 76316 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 382 | 2 | 2 | 2 | 4.8 | O[C@H]1Cc2ccccc2C12CCN(Cc1ccc3[nH]c4ccccc4c3c1)CC2 | 10.1016/j.bmcl.2011.10.125 | ||
CHEMBL1934117 | 76316 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 382 | 2 | 2 | 2 | 4.8 | O[C@H]1Cc2ccccc2C12CCN(Cc1ccc3[nH]c4ccccc4c3c1)CC2 | 10.1016/j.bmcl.2011.10.125 | ||
7757 | 7864 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Functional | Guide to Pharmacology | 466 | 5 | 2 | 4 | 5.7 | CCCN[C@@H]1CC2(c3c1cccc3)CCN(CC2)Cc1ccc2c(c1)c1ccccc1n2C(=O)N | 22123324 | ||
86277835 | 7864 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Functional | Guide to Pharmacology | 466 | 5 | 2 | 4 | 5.7 | CCCN[C@@H]1CC2(c3c1cccc3)CCN(CC2)Cc1ccc2c(c1)c1ccccc1n2C(=O)N | 22123324 | ||
11238212 | 7298 | 0 | None | - | 1 | Human | 5.9 | pIC50 | None | 5.9 | Functional | Guide to Pharmacology | 551 | 8 | 2 | 6 | 5.9 | Brc1ccc(c(c1)OC(F)(F)F)CCN[C@@H]1CC[C@@H](CC1)Nc1nc2ccccc2c(n1)N(C)C | 15677346 | ||
1304 | 7298 | 0 | None | - | 1 | Human | 5.9 | pIC50 | None | 5.9 | Functional | Guide to Pharmacology | 551 | 8 | 2 | 6 | 5.9 | Brc1ccc(c(c1)OC(F)(F)F)CCN[C@@H]1CC[C@@H](CC1)Nc1nc2ccccc2c(n1)N(C)C | 15677346 | ||
101600353 | 9248 | 0 | None | - | 1 | Human | 6.7 | pIC50 | None | 6.7 | Functional | Guide to Pharmacology | None | None | None | None | 11404457 | ||||
101600353 | 9248 | 0 | None | - | 1 | Human | 6.7 | pIC50 | None | 6.7 | Functional | Guide to Pharmacology | None | None | None | None | 11459838 | ||||
1301 | 9248 | 0 | None | - | 1 | Human | 6.7 | pIC50 | None | 6.7 | Functional | Guide to Pharmacology | None | None | None | None | 11404457 | ||||
1301 | 9248 | 0 | None | - | 1 | Human | 6.7 | pIC50 | None | 6.7 | Functional | Guide to Pharmacology | None | None | None | None | 11459838 | ||||
134824567 | 9248 | 0 | None | - | 1 | Human | 6.7 | pIC50 | None | 6.7 | Functional | Guide to Pharmacology | None | None | None | None | 11404457 | ||||
134824567 | 9248 | 0 | None | - | 1 | Human | 6.7 | pIC50 | None | 6.7 | Functional | Guide to Pharmacology | None | None | None | None | 11459838 | ||||
16207764 | 9248 | 0 | None | - | 1 | Human | 6.7 | pIC50 | None | 6.7 | Functional | Guide to Pharmacology | None | None | None | None | 11404457 | ||||
16207764 | 9248 | 0 | None | - | 1 | Human | 6.7 | pIC50 | None | 6.7 | Functional | Guide to Pharmacology | None | None | None | None | 11459838 | ||||
1307 | 7316 | 0 | None | 1 | 2 | Human | 7.3 | pIC50 | None | 7.3 | Functional | Guide to Pharmacology | None | None | None | None | 12009900 | ||||
1290 | 7046 | 0 | None | -15 | 2 | Human | 8.6 | pIC50 | None | 8.6 | Functional | Guide to Pharmacology | None | None | None | None | 12009900 | ||||
1298 | 9262 | 0 | None | - | 1 | Human | 8.7 | pIC50 | None | 8.7 | Functional | Guide to Pharmacology | None | None | None | None | 11404457 | ||||
16167454 | 9262 | 0 | None | - | 1 | Human | 8.7 | pIC50 | None | 8.7 | Functional | Guide to Pharmacology | None | None | None | None | 11404457 | ||||
91898993 | 9262 | 0 | None | - | 1 | Human | 8.7 | pIC50 | None | 8.7 | Functional | Guide to Pharmacology | None | None | None | None | 11404457 | ||||
1297 | 9877 | 0 | None | -1 | 2 | Human | 8.8 | pIC50 | None | 8.8 | Functional | Guide to Pharmacology | None | None | None | None | 11404457 | ||||
1297 | 9877 | 0 | None | -1 | 2 | Human | 8.8 | pIC50 | None | 8.8 | Functional | Guide to Pharmacology | None | None | None | None | 11459838 |
Ligands (move mouse cursor over ligand name to see structure) | Receptor | Assay information | Chemical information | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Similar- ity |
Common name |
GPCRdb ID |
#Vendors |
Reference ligand |
Fold selectivity |
# Tested GPCRs |
Species |
p-value (-log) |
Activity Type |
Activity Relation |
Activity Value |
Assay Type |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
9806086 | 71981 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 502 | 10 | 3 | 5 | 5.7 | COc1cc(NC(=O)Nc2ccc(Oc3ccccc3)cc2)ccc1C(=O)NCCCN1CCCCC1 | 10.1016/j.bmcl.2004.07.077 | |||
CHEMBL182554 | 71981 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 502 | 10 | 3 | 5 | 5.7 | COc1cc(NC(=O)Nc2ccc(Oc3ccccc3)cc2)ccc1C(=O)NCCCN1CCCCC1 | 10.1016/j.bmcl.2004.07.077 | |||
10436090 | 72980 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 501 | 10 | 4 | 5 | 5.7 | COc1cc(NC(=O)Nc2cccc(Nc3ccccc3)c2)ccc1C(=O)NCCCN1CCCCC1 | 10.1016/j.bmcl.2004.07.077 | |||
CHEMBL184438 | 72980 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 501 | 10 | 4 | 5 | 5.7 | COc1cc(NC(=O)Nc2cccc(Nc3ccccc3)c2)ccc1C(=O)NCCCN1CCCCC1 | 10.1016/j.bmcl.2004.07.077 | |||
44395076 | 73770 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 549 | 10 | 3 | 5 | 5.7 | O=C(Nc1ccc(Oc2ccccc2)cc1)Nc1ccc(C(=O)NCCN2CCN(Cc3ccccc3)CC2)cc1 | 10.1016/j.bmcl.2004.07.077 | |||
CHEMBL186894 | 73770 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 549 | 10 | 3 | 5 | 5.7 | O=C(Nc1ccc(Oc2ccccc2)cc1)Nc1ccc(C(=O)NCCN2CCN(Cc3ccccc3)CC2)cc1 | 10.1016/j.bmcl.2004.07.077 | |||
10388797 | 78534 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 444 | 5 | 2 | 5 | 4.3 | Cc1cc(N2CCNCC2)nc2ccc(NC(=O)COc3ccc(Cl)cc3Cl)cc12 | 10.1021/jm050103y | |||
CHEMBL196667 | 78534 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 444 | 5 | 2 | 5 | 4.3 | Cc1cc(N2CCNCC2)nc2ccc(NC(=O)COc3ccc(Cl)cc3Cl)cc12 | 10.1021/jm050103y | |||
11512135 | 77083 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 460 | 8 | 1 | 5 | 4.9 | Cc1cc(N(C)CCN(C)C)nc2ccc(NC(=O)COc3ccc(Cl)cc3Cl)cc12 | 10.1021/jm050103y | |||
CHEMBL194408 | 77083 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 460 | 8 | 1 | 5 | 4.9 | Cc1cc(N(C)CCN(C)C)nc2ccc(NC(=O)COc3ccc(Cl)cc3Cl)cc12 | 10.1021/jm050103y | |||
10027853 | 78637 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 474 | 6 | 2 | 6 | 4.4 | Cc1cc(N2CCC(N)CC2)nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cc12 | 10.1021/jm050103y | |||
CHEMBL197026 | 78637 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 474 | 6 | 2 | 6 | 4.4 | Cc1cc(N2CCC(N)CC2)nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cc12 | 10.1021/jm050103y | |||
11599973 | 201676 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 600 | 8 | 2 | 4 | 6.5 | O=C(CC1CCN(Cc2ccn(-c3ccc(C(F)(F)F)cc3)c2)CC1)NC(c1ccc(F)cc1)c1c[nH]c(=O)c(Cl)c1 | 10.1016/j.bmcl.2009.05.067 | |||
CHEMBL540930 | 201676 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 600 | 8 | 2 | 4 | 6.5 | O=C(CC1CCN(Cc2ccn(-c3ccc(C(F)(F)F)cc3)c2)CC1)NC(c1ccc(F)cc1)c1c[nH]c(=O)c(Cl)c1 | 10.1016/j.bmcl.2009.05.067 | |||
11548234 | 77971 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 528 | 7 | 1 | 6 | 5.5 | Cc1cc(N2CCC(N3CCCC3)CC2)nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cc12 | 10.1021/jm050103y | |||
CHEMBL195635 | 77971 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 528 | 7 | 1 | 6 | 5.5 | Cc1cc(N2CCC(N3CCCC3)CC2)nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cc12 | 10.1021/jm050103y | |||
11201645 | 78646 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 445 | 7 | 2 | 5 | 4.5 | Cc1cc(N(C)CCO)nc2ccc(NC(=O)/C=C/c3ccc(OC(F)(F)F)cc3)cc12 | 10.1021/jm050103y | |||
CHEMBL197050 | 78646 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 445 | 7 | 2 | 5 | 4.5 | Cc1cc(N(C)CCO)nc2ccc(NC(=O)/C=C/c3ccc(OC(F)(F)F)cc3)cc12 | 10.1021/jm050103y | |||
44403765 | 142638 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 446 | 8 | 2 | 5 | 4.5 | CNCCN(C)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3Cl)ccc2n1 | 10.1021/jm050103y | |||
CHEMBL373084 | 142638 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 446 | 8 | 2 | 5 | 4.5 | CNCCN(C)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3Cl)ccc2n1 | 10.1021/jm050103y | |||
10005009 | 173155 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 472 | 6 | 2 | 6 | 4.0 | Cc1cc(N2CC3CC2CN3)nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cc12 | 10.1021/jm050103y | |||
CHEMBL427540 | 173155 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 472 | 6 | 2 | 6 | 4.0 | Cc1cc(N2CC3CC2CN3)nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cc12 | 10.1021/jm050103y | |||
9955811 | 72945 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 458 | 8 | 3 | 4 | 5.3 | CCN1CCCC1CNC(=O)c1ccc(NC(=O)Nc2ccc(Oc3ccccc3)cc2)cc1 | 10.1016/j.bmcl.2004.07.077 | |||
CHEMBL184292 | 72945 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 458 | 8 | 3 | 4 | 5.3 | CCN1CCCC1CNC(=O)c1ccc(NC(=O)Nc2ccc(Oc3ccccc3)cc2)cc1 | 10.1016/j.bmcl.2004.07.077 | |||
11583744 | 78499 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 476 | 10 | 2 | 6 | 4.8 | Cc1cc(NCCCN(C)C)nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cc12 | 10.1021/jm050103y | |||
CHEMBL196581 | 78499 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 476 | 10 | 2 | 6 | 4.8 | Cc1cc(NCCCN(C)C)nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cc12 | 10.1021/jm050103y | |||
11648240 | 78236 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 458 | 8 | 2 | 5 | 5.1 | Cc1cc(NCCN(C)C)nc2ccc(NC(=O)/C=C/c3ccc(OC(F)(F)F)cc3)cc12 | 10.1021/jm050103y | |||
CHEMBL196196 | 78236 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 458 | 8 | 2 | 5 | 5.1 | Cc1cc(NCCN(C)C)nc2ccc(NC(=O)/C=C/c3ccc(OC(F)(F)F)cc3)cc12 | 10.1021/jm050103y | |||
11539632 | 77336 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 447 | 8 | 1 | 5 | 4.8 | Cc1cc(OCCN(C)C)nc2ccc(NC(=O)COc3ccc(Cl)cc3Cl)cc12 | 10.1021/jm050103y | |||
CHEMBL194837 | 77336 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 447 | 8 | 1 | 5 | 4.8 | Cc1cc(OCCN(C)C)nc2ccc(NC(=O)COc3ccc(Cl)cc3Cl)cc12 | 10.1021/jm050103y | |||
10173787 | 89213 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 453 | 7 | 2 | 3 | 6.8 | CCCc1cc(NC2CCC2)c2cc(NC(=O)/C=C/c3ccc(C(F)(F)F)cc3)ccc2n1 | 10.1016/j.bmcl.2006.08.008 | |||
CHEMBL217480 | 89213 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 453 | 7 | 2 | 3 | 6.8 | CCCc1cc(NC2CCC2)c2cc(NC(=O)/C=C/c3ccc(C(F)(F)F)cc3)ccc2n1 | 10.1016/j.bmcl.2006.08.008 | |||
45273336 | 202541 | 0 | None | -46 | 3 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 2419 | 58 | 33 | 31 | -3.5 | CSCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H]1CSSC[C@@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CCC(N)=O)CN[C@@H](Cc2ccc(O)cc2)C(=O)O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC1=O | 10.1016/j.bmcl.2009.03.102 | |||
91934329 | 202541 | 0 | None | -46 | 3 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 2419 | 58 | 33 | 31 | -3.5 | CSCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H]1CSSC[C@@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CCC(N)=O)CN[C@@H](Cc2ccc(O)cc2)C(=O)O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC1=O | 10.1016/j.bmcl.2009.03.102 | |||
CHEMBL557629 | 202541 | 0 | None | -46 | 3 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 2419 | 58 | 33 | 31 | -3.5 | CSCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H]1CSSC[C@@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CCC(N)=O)CN[C@@H](Cc2ccc(O)cc2)C(=O)O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC1=O | 10.1016/j.bmcl.2009.03.102 | |||
10457264 | 76329 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 466 | 3 | 2 | 4 | 4.8 | CC(=O)N[C@@H]1CC2(CCN(Cc3ccc4c(c3)c3ccccc3n4C(N)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2011.10.125 | |||
CHEMBL1934130 | 76329 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 466 | 3 | 2 | 4 | 4.8 | CC(=O)N[C@@H]1CC2(CCN(Cc3ccc4c(c3)c3ccccc3n4C(N)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2011.10.125 |