Ligand source activities (1 row/activity)





Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
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DOI

101635584 9376 31 None - 1 Human 10.4 pEC50 = 10.4 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay
ChEMBL None None None None 10.1021/jm801332q
1458 9376 31 None - 1 Human 10.4 pEC50 = 10.4 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay
ChEMBL None None None None 10.1021/jm801332q
16136567 9376 31 None - 1 Human 10.4 pEC50 = 10.4 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay
ChEMBL None None None None 10.1021/jm801332q
3794 9376 31 None - 1 Human 10.4 pEC50 = 10.4 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay
ChEMBL None None None None 10.1021/jm801332q
91898963 9376 31 None - 1 Human 10.4 pEC50 = 10.4 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay
ChEMBL None None None None 10.1021/jm801332q
CHEMBL525634 9376 31 None - 1 Human 10.4 pEC50 = 10.4 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay
ChEMBL None None None None 10.1021/jm801332q
10010118 108212 0 None - 1 Human 10.3 pEC50 = 10.3 Functional
In vitro effective concentration towards human motilin receptorIn vitro effective concentration towards human motilin receptor
ChEMBL 723 13 4 11 1.7 NC(=O)[C@H](CCc1ccccc1)NC(=O)[C@H](CCc1ccccc1)NC(=O)C1CCC2(CCNCC2)n2c(=O)n(Cc3ccc4c(c3)OCO4)c(=O)n21 10.1021/jm0304865
CHEMBL297494 108212 0 None - 1 Human 10.3 pEC50 = 10.3 Functional
In vitro effective concentration towards human motilin receptorIn vitro effective concentration towards human motilin receptor
ChEMBL 723 13 4 11 1.7 NC(=O)[C@H](CCc1ccccc1)NC(=O)[C@H](CCc1ccccc1)NC(=O)C1CCC2(CCNCC2)n2c(=O)n(Cc3ccc4c(c3)OCO4)c(=O)n21 10.1021/jm0304865
CHEMBL2372767 217064 0 None - 1 Human 9.8 pEC50 = 9.8 Functional
In vitro effective concentration towards human motilin receptorIn vitro effective concentration towards human motilin receptor
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccccc1)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)O)[C@@H](C)O 10.1021/jm0304865
11181688 108112 0 None - 1 Human 9.7 pEC50 = 9.7 Functional
In vitro effective concentration towards human motilin receptorIn vitro effective concentration towards human motilin receptor
ChEMBL 721 13 4 11 1.5 NC(=O)[C@H](CCc1ccccc1)NC(=O)[C@H](CCc1ccccc1)NC(=O)C1C=CC2(CCNCC2)n2c(=O)n(Cc3ccc4c(c3)OCO4)c(=O)n21 10.1021/jm0304865
CHEMBL296748 108112 0 None - 1 Human 9.7 pEC50 = 9.7 Functional
In vitro effective concentration towards human motilin receptorIn vitro effective concentration towards human motilin receptor
ChEMBL 721 13 4 11 1.5 NC(=O)[C@H](CCc1ccccc1)NC(=O)[C@H](CCc1ccccc1)NC(=O)C1C=CC2(CCNCC2)n2c(=O)n(Cc3ccc4c(c3)OCO4)c(=O)n21 10.1021/jm0304865
23728661 95605 0 None - 1 Human 9.6 pEC50 = 9.6 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 432 5 1 4 4.3 Cc1cc(N(C)C(=O)c2ccc(-c3cccc(F)c3)nc2)ccc1CN1CCN[C@@H](C)C1 10.6019/CHEMBL2364262
CHEMBL2364292 95605 0 None - 1 Human 9.6 pEC50 = 9.6 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 432 5 1 4 4.3 Cc1cc(N(C)C(=O)c2ccc(-c3cccc(F)c3)nc2)ccc1CN1CCN[C@@H](C)C1 10.6019/CHEMBL2364262
23728772 95626 0 None - 1 Human 9.6 pEC50 = 9.6 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 448 6 1 5 4.4 Cc1cc(N(C)C(=O)c2ccc(Oc3ccc(F)cc3)nc2)ccc1CN1CCN[C@@H](C)C1 10.6019/CHEMBL2364262
CHEMBL2364312 95626 0 None - 1 Human 9.6 pEC50 = 9.6 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 448 6 1 5 4.4 Cc1cc(N(C)C(=O)c2ccc(Oc3ccc(F)cc3)nc2)ccc1CN1CCN[C@@H](C)C1 10.6019/CHEMBL2364262
23728875 95631 0 None - 1 Human 9.5 pEC50 = 9.5 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 468 6 1 5 4.7 C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(Oc4ccc(F)cc4)nc3)cc2Cl)CCN1 10.6019/CHEMBL2364262
CHEMBL2364317 95631 0 None - 1 Human 9.5 pEC50 = 9.5 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 468 6 1 5 4.7 C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(Oc4ccc(F)cc4)nc3)cc2Cl)CCN1 10.6019/CHEMBL2364262
10010118 108212 0 None - 1 Human 9.5 pEC50 = 9.5 Functional
In vitro effective concentration towards human motilin receptorIn vitro effective concentration towards human motilin receptor
ChEMBL 723 13 4 11 1.7 NC(=O)[C@H](CCc1ccccc1)NC(=O)[C@H](CCc1ccccc1)NC(=O)C1CCC2(CCNCC2)n2c(=O)n(Cc3ccc4c(c3)OCO4)c(=O)n21 10.1021/jm0304865
CHEMBL297494 108212 0 None - 1 Human 9.5 pEC50 = 9.5 Functional
In vitro effective concentration towards human motilin receptorIn vitro effective concentration towards human motilin receptor
ChEMBL 723 13 4 11 1.7 NC(=O)[C@H](CCc1ccccc1)NC(=O)[C@H](CCc1ccccc1)NC(=O)C1CCC2(CCNCC2)n2c(=O)n(Cc3ccc4c(c3)OCO4)c(=O)n21 10.1021/jm0304865
23728544 95598 0 None - 1 Human 9.4 pEC50 = 9.4 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 446 5 1 4 4.7 Cc1nc(-c2ccc(F)cc2)ccc1C(=O)N(C)c1ccc(CN2C[C@H](C)N[C@H](C)C2)cc1 10.6019/CHEMBL2364262
CHEMBL2364285 95598 0 None - 1 Human 9.4 pEC50 = 9.4 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 446 5 1 4 4.7 Cc1nc(-c2ccc(F)cc2)ccc1C(=O)N(C)c1ccc(CN2C[C@H](C)N[C@H](C)C2)cc1 10.6019/CHEMBL2364262
23728806 95632 0 None - 1 Human 9.4 pEC50 = 9.4 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 448 7 1 5 4.5 CCN(C(=O)c1ccc(Oc2ccc(F)cc2)nc1)c1ccc(CN2CCN[C@@H](C)C2)cc1 10.6019/CHEMBL2364262
CHEMBL2364318 95632 0 None - 1 Human 9.4 pEC50 = 9.4 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 448 7 1 5 4.5 CCN(C(=O)c1ccc(Oc2ccc(F)cc2)nc1)c1ccc(CN2CCN[C@@H](C)C2)cc1 10.6019/CHEMBL2364262
23729106 95595 0 None - 1 Human 9.2 pEC50 = 9.2 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 432 5 1 4 4.3 Cc1nc(-c2cccc(F)c2)ccc1C(=O)N(C)c1ccc(CN2CCN[C@@H](C)C2)cc1 10.6019/CHEMBL2364262
CHEMBL2364282 95595 0 None - 1 Human 9.2 pEC50 = 9.2 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 432 5 1 4 4.3 Cc1nc(-c2cccc(F)c2)ccc1C(=O)N(C)c1ccc(CN2CCN[C@@H](C)C2)cc1 10.6019/CHEMBL2364262
23728770 95615 0 None - 1 Human 9.1 pEC50 = 9.1 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 432 6 1 4 4.3 CCN(C(=O)c1ccc(-c2cccc(F)c2)nc1)c1ccc(CN2CCN[C@@H](C)C2)cc1 10.6019/CHEMBL2364262
CHEMBL2364302 95615 0 None - 1 Human 9.1 pEC50 = 9.1 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 432 6 1 4 4.3 CCN(C(=O)c1ccc(-c2cccc(F)c2)nc1)c1ccc(CN2CCN[C@@H](C)C2)cc1 10.6019/CHEMBL2364262
16749783 95644 0 None - 1 Human 9.1 pEC50 = 9.1 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 450 6 1 7 3.2 C[C@H]1CN(Cc2ccn(-c3cccnc3N3CCC(Oc4cccc(F)c4)CC3)n2)CCN1 10.6019/CHEMBL2364262
CHEMBL2364330 95644 0 None - 1 Human 9.1 pEC50 = 9.1 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 450 6 1 7 3.2 C[C@H]1CN(Cc2ccn(-c3cccnc3N3CCC(Oc4cccc(F)c4)CC3)n2)CCN1 10.6019/CHEMBL2364262
101635584 9376 31 None - 1 Human 9.0 pEC50 = 9.0 Functional
Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells
ChEMBL None None None None 10.1016/j.bmcl.2022.128554
1458 9376 31 None - 1 Human 9.0 pEC50 = 9.0 Functional
Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells
ChEMBL None None None None 10.1016/j.bmcl.2022.128554
16136567 9376 31 None - 1 Human 9.0 pEC50 = 9.0 Functional
Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells
ChEMBL None None None None 10.1016/j.bmcl.2022.128554
3794 9376 31 None - 1 Human 9.0 pEC50 = 9.0 Functional
Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells
ChEMBL None None None None 10.1016/j.bmcl.2022.128554
91898963 9376 31 None - 1 Human 9.0 pEC50 = 9.0 Functional
Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells
ChEMBL None None None None 10.1016/j.bmcl.2022.128554
CHEMBL525634 9376 31 None - 1 Human 9.0 pEC50 = 9.0 Functional
Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells
ChEMBL None None None None 10.1016/j.bmcl.2022.128554
23728693 95610 0 None - 1 Human 9.0 pEC50 = 9 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 434 6 1 5 4.1 C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(Oc4cccc(F)c4)cn3)cc2)CCN1 10.6019/CHEMBL2364262
CHEMBL2364297 95610 0 None - 1 Human 9.0 pEC50 = 9 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 434 6 1 5 4.1 C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(Oc4cccc(F)c4)cn3)cc2)CCN1 10.6019/CHEMBL2364262
16040758 95640 0 None - 1 Human 9.0 pEC50 = 9 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 487 6 2 5 4.4 C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)CCN1 10.6019/CHEMBL2364262
CHEMBL2364326 95640 0 None - 1 Human 9.0 pEC50 = 9 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 487 6 2 5 4.4 C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)CCN1 10.6019/CHEMBL2364262
23729022 95594 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 418 5 1 4 4.0 C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(-c4cccc(F)c4)nc3)cc2)CCN1 10.6019/CHEMBL2364262
CHEMBL2364281 95594 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 418 5 1 4 4.0 C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(-c4cccc(F)c4)nc3)cc2)CCN1 10.6019/CHEMBL2364262
23728731 95614 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 436 5 1 4 4.1 C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(-c4cccc(F)c4)nc3)cc2F)CCN1 10.6019/CHEMBL2364262
CHEMBL2364301 95614 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 436 5 1 4 4.1 C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(-c4cccc(F)c4)nc3)cc2F)CCN1 10.6019/CHEMBL2364262
16749753 95643 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 464 6 1 7 3.6 C[C@H]1CN(Cc2ccn(-c3cccnc3N3CCC(Oc4ccc(F)cc4)CC3)n2)C[C@@H](C)N1 10.6019/CHEMBL2364262
CHEMBL2364329 95643 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 464 6 1 7 3.6 C[C@H]1CN(Cc2ccn(-c3cccnc3N3CCC(Oc4ccc(F)cc4)CC3)n2)C[C@@H](C)N1 10.6019/CHEMBL2364262
23729025 95590 0 None - 1 Human 8.8 pEC50 = 8.8 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 418 5 1 4 4.0 C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(-c4ccc(F)cc4)nc3)cc2)CCN1 10.6019/CHEMBL2364262
CHEMBL2364277 95590 0 None - 1 Human 8.8 pEC50 = 8.8 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 418 5 1 4 4.0 C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(-c4ccc(F)cc4)nc3)cc2)CCN1 10.6019/CHEMBL2364262
23728541 95597 0 None - 1 Human 8.8 pEC50 = 8.8 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 439 5 1 5 4.0 Cc1nc(-c2cccc(C#N)c2)ccc1C(=O)N(C)c1ccc(CN2CCN[C@@H](C)C2)cc1 10.6019/CHEMBL2364262
CHEMBL2364284 95597 0 None - 1 Human 8.8 pEC50 = 8.8 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 439 5 1 5 4.0 Cc1nc(-c2cccc(C#N)c2)ccc1C(=O)N(C)c1ccc(CN2CCN[C@@H](C)C2)cc1 10.6019/CHEMBL2364262
23728581 95601 0 None - 1 Human 8.8 pEC50 = 8.8 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 433 5 1 5 3.7 Cc1nc(-c2ccc(F)cc2)ncc1C(=O)N(C)c1ccc(CN2CCN[C@@H](C)C2)cc1 10.6019/CHEMBL2364262
CHEMBL2364288 95601 0 None - 1 Human 8.8 pEC50 = 8.8 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 433 5 1 5 3.7 Cc1nc(-c2ccc(F)cc2)ncc1C(=O)N(C)c1ccc(CN2CCN[C@@H](C)C2)cc1 10.6019/CHEMBL2364262
42623380 95629 0 None - 1 Human 8.8 pEC50 = 8.8 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 454 6 2 5 3.8 Cc1cc(NS(=O)(=O)c2ccc(-c3ccc(F)cc3)nc2)ccc1CN1CCN[C@@H](C)C1 10.6019/CHEMBL2364262
CHEMBL2364315 95629 0 None - 1 Human 8.8 pEC50 = 8.8 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 454 6 2 5 3.8 Cc1cc(NS(=O)(=O)c2ccc(-c3ccc(F)cc3)nc2)ccc1CN1CCN[C@@H](C)C1 10.6019/CHEMBL2364262
42623463 95634 0 None - 1 Human 8.8 pEC50 = 8.8 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 508 6 2 5 4.5 C[C@H]1CN(Cc2ccc(NS(=O)(=O)c3ccc(-c4ccc(F)cc4)nc3)cc2C(F)(F)F)CCN1 10.6019/CHEMBL2364262
CHEMBL2364320 95634 0 None - 1 Human 8.8 pEC50 = 8.8 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 508 6 2 5 4.5 C[C@H]1CN(Cc2ccc(NS(=O)(=O)c3ccc(-c4ccc(F)cc4)nc3)cc2C(F)(F)F)CCN1 10.6019/CHEMBL2364262
56959013 198178 0 None - 1 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells
ChEMBL 534 9 2 5 4.5 Cc1cc(N(C)C(=O)[C@H]2CC[C@H](Oc3cccc(CC(=O)NC(C)C)c3)CC2)ccc1CN1CCN[C@@H](C)C1 10.1016/j.bmcl.2022.128554
CHEMBL5192530 198178 0 None - 1 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells
ChEMBL 534 9 2 5 4.5 Cc1cc(N(C)C(=O)[C@H]2CC[C@H](Oc3cccc(CC(=O)NC(C)C)c3)CC2)ccc1CN1CCN[C@@H](C)C1 10.1016/j.bmcl.2022.128554
89723534 197306 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells
ChEMBL 499 7 2 5 4.5 Cc1cc(N(C)C(=O)[C@H]2CC[C@H](Oc3ccc(Cl)c(CO)c3)CC2)ccc1CN1CCN[C@@H](C)C1 10.1016/j.bmcl.2022.128554
CHEMBL5179573 197306 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells
ChEMBL 499 7 2 5 4.5 Cc1cc(N(C)C(=O)[C@H]2CC[C@H](Oc3ccc(Cl)c(CO)c3)CC2)ccc1CN1CCN[C@@H](C)C1 10.1016/j.bmcl.2022.128554
16041119 185183 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 519 6 2 5 4.9 C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(F)c(F)c4)CC3)cc2)C[C@@H](C)N1 10.1016/j.bmcl.2008.10.072
CHEMBL465917 185183 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 519 6 2 5 4.9 C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(F)c(F)c4)CC3)cc2)C[C@@H](C)N1 10.1016/j.bmcl.2008.10.072
23728546 95599 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 432 5 1 4 4.3 C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(-c4ccc(F)cc4)nc3)cc2)C[C@@H](C)N1 10.6019/CHEMBL2364262
CHEMBL2364286 95599 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 432 5 1 4 4.3 C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(-c4ccc(F)cc4)nc3)cc2)C[C@@H](C)N1 10.6019/CHEMBL2364262
59262141 95612 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 441 6 1 6 3.8 C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(Oc4cccc(C#N)c4)cn3)cc2)CCN1 10.6019/CHEMBL2364262
CHEMBL2364299 95612 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 441 6 1 6 3.8 C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(Oc4cccc(C#N)c4)cn3)cc2)CCN1 10.6019/CHEMBL2364262
23728915 95635 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 449 6 1 6 3.8 Cc1cc(N(C)C(=O)c2ccc(Oc3ccc(F)cc3)nc2)ncc1CN1CCN[C@@H](C)C1 10.6019/CHEMBL2364262
CHEMBL2364321 95635 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 449 6 1 6 3.8 Cc1cc(N(C)C(=O)c2ccc(Oc3ccc(F)cc3)nc2)ncc1CN1CCN[C@@H](C)C1 10.6019/CHEMBL2364262
16122912 95637 1 None - 1 Human 8.7 pEC50 = 8.7 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 463 6 2 7 3.7 C[C@H]1CN(Cc2ccn(-c3cccnc3N3CCC(Nc4ccc(F)cc4)CC3)n2)C[C@@H](C)N1 10.6019/CHEMBL2364262
CHEMBL2364323 95637 1 None - 1 Human 8.7 pEC50 = 8.7 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 463 6 2 7 3.7 C[C@H]1CN(Cc2ccn(-c3cccnc3N3CCC(Nc4ccc(F)cc4)CC3)n2)C[C@@H](C)N1 10.6019/CHEMBL2364262
15984938 193566 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay
ChEMBL 424 6 2 4 3.3 C[C@H]1CN(Cc2ccc(CC(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)CCN1 10.1021/jm801332q
CHEMBL489094 193566 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay
ChEMBL 424 6 2 4 3.3 C[C@H]1CN(Cc2ccc(CC(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)CCN1 10.1021/jm801332q
46882521 12483 0 None 158 2 Human 8.0 pEC50 = 8 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 458 6 2 4 4.5 O=S(=O)(Nc1ccc2c(c1)CCN(Cc1cc[nH]n1)CC2)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2009.09.027
CHEMBL1078207 12483 0 None 158 2 Human 8.0 pEC50 = 8 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 458 6 2 4 4.5 O=S(=O)(Nc1ccc2c(c1)CCN(Cc1cc[nH]n1)CC2)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2009.09.027
16752689 195147 0 None 5 3 Human 8.0 pEC50 = 8 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 568 10 2 4 6.6 COc1cccc(CCN(Cc2ccccc2-c2ccc(CN3C[C@H](C)N[C@H](C)C3)cc2)C(=O)NC2CCCCC2)c1 10.1016/j.bmcl.2008.10.072
CHEMBL501315 195147 0 None 5 3 Human 8.0 pEC50 = 8 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 568 10 2 4 6.6 COc1cccc(CCN(Cc2ccccc2-c2ccc(CN3C[C@H](C)N[C@H](C)C3)cc2)C(=O)NC2CCCCC2)c1 10.1016/j.bmcl.2008.10.072
16752689 195147 0 None 5 3 Human 8.0 pEC50 = 8 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay
ChEMBL 568 10 2 4 6.6 COc1cccc(CCN(Cc2ccccc2-c2ccc(CN3C[C@H](C)N[C@H](C)C3)cc2)C(=O)NC2CCCCC2)c1 10.1016/j.bmcl.2008.10.071
CHEMBL501315 195147 0 None 5 3 Human 8.0 pEC50 = 8 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay
ChEMBL 568 10 2 4 6.6 COc1cccc(CCN(Cc2ccccc2-c2ccc(CN3C[C@H](C)N[C@H](C)C3)cc2)C(=O)NC2CCCCC2)c1 10.1016/j.bmcl.2008.10.071
16040941 185067 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 519 6 2 5 4.9 C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4cccc(F)c4)CC3)cc2F)C[C@@H](C)N1 10.1016/j.bmcl.2008.10.072
CHEMBL465094 185067 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 519 6 2 5 4.9 C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4cccc(F)c4)CC3)cc2F)C[C@@H](C)N1 10.1016/j.bmcl.2008.10.072
11993730 185186 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 500 6 1 4 5.2 C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Cc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1 10.1016/j.bmcl.2008.10.072
CHEMBL465925 185186 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 500 6 1 4 5.2 C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Cc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1 10.1016/j.bmcl.2008.10.072
44570412 185200 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 505 8 1 5 4.0 C[C@H]1CN(Cc2ccc(-c3ccccc3CN(C)C(=O)CS(=O)(=O)c3ccccc3)cc2)C[C@@H](C)N1 10.1016/j.bmcl.2008.10.072
CHEMBL465948 185200 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 505 8 1 5 4.0 C[C@H]1CN(Cc2ccc(-c3ccccc3CN(C)C(=O)CS(=O)(=O)c3ccccc3)cc2)C[C@@H](C)N1 10.1016/j.bmcl.2008.10.072
44570489 189838 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 499 6 1 3 5.8 C[C@H]1CN(Cc2ccc(-c3ccccc3C(=O)N3CCC(Cc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1 10.1016/j.bmcl.2008.10.072
CHEMBL479418 189838 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 499 6 1 3 5.8 C[C@H]1CN(Cc2ccc(-c3ccccc3C(=O)N3CCC(Cc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1 10.1016/j.bmcl.2008.10.072
15985000 95581 0 None - 1 Human 8.0 pEC50 = 8 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 474 6 2 4 4.1 C[C@H]1CN(Cc2ccc(CC(=O)N3CCC(Nc4ccc(C(F)(F)F)cc4)CC3)cc2)CCN1 10.6019/CHEMBL2364262
CHEMBL2364268 95581 0 None - 1 Human 8.0 pEC50 = 8 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 474 6 2 4 4.1 C[C@H]1CN(Cc2ccc(CC(=O)N3CCC(Nc4ccc(C(F)(F)F)cc4)CC3)cc2)CCN1 10.6019/CHEMBL2364262
44571939 187395 0 None - 1 Human 7.0 pEC50 = 7 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assay
ChEMBL 540 10 2 4 5.9 COc1cccc(CCN(Cc2ccccc2-c2ccc(CN3CCNCC3)cc2)C(=O)NC2CCCCC2)c1 10.1016/j.bmcl.2008.10.071
CHEMBL475467 187395 0 None - 1 Human 7.0 pEC50 = 7 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assay
ChEMBL 540 10 2 4 5.9 COc1cccc(CCN(Cc2ccccc2-c2ccc(CN3CCNCC3)cc2)C(=O)NC2CCCCC2)c1 10.1016/j.bmcl.2008.10.071
52946479 24003 0 None - 1 Rabbit 7.0 pEC50 = 7 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction
ChEMBL 794 9 7 15 1.7 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC(C)(C)O)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2010.08.030
CHEMBL1256547 24003 0 None - 1 Rabbit 7.0 pEC50 = 7 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction
ChEMBL 794 9 7 15 1.7 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC(C)(C)O)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2010.08.030
52946426 24011 0 None - 1 Rabbit 7.0 pEC50 = 7 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction
ChEMBL 778 9 6 14 2.6 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC(C)(C)O)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@H]1C 10.1016/j.bmcl.2010.08.030
CHEMBL1256558 24011 0 None - 1 Rabbit 7.0 pEC50 = 7 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction
ChEMBL 778 9 6 14 2.6 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC(C)(C)O)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@H]1C 10.1016/j.bmcl.2010.08.030
54584627 69001 0 None - 1 Rabbit 7.0 pEC50 = 7 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 794 9 7 15 1.7 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC(C)(C)O)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2011.04.078
CHEMBL1778155 69001 0 None - 1 Rabbit 7.0 pEC50 = 7 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 794 9 7 15 1.7 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC(C)(C)O)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2011.04.078
42623375 95606 0 None - 1 Human 7.0 pEC50 = 7 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 429 6 2 6 2.7 C[C@H]1CN(Cc2ccc(NS(=O)(=O)c3ccc(N4CCCCC4)nc3)cc2)CCN1 10.6019/CHEMBL2364262
CHEMBL2364293 95606 0 None - 1 Human 7.0 pEC50 = 7 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 429 6 2 6 2.7 C[C@H]1CN(Cc2ccc(NS(=O)(=O)c3ccc(N4CCCCC4)nc3)cc2)CCN1 10.6019/CHEMBL2364262
44570112 184208 0 None - 1 Human 6.0 pEC50 = 6 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 513 7 2 6 4.7 COc1ccc(NC2CCN(C(=O)c3ncccc3-c3ccc(CN4C[C@H](C)N[C@H](C)C4)cc3)CC2)cc1 10.1016/j.bmcl.2008.10.072
CHEMBL463861 184208 0 None - 1 Human 6.0 pEC50 = 6 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 513 7 2 6 4.7 COc1ccc(NC2CCN(C(=O)c3ncccc3-c3ccc(CN4C[C@H](C)N[C@H](C)C4)cc3)CC2)cc1 10.1016/j.bmcl.2008.10.072
44570452 196611 0 None - 1 Human 6.0 pEC50 = 6 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 446 7 1 5 4.0 Cc1cc(CC(=O)N(C)Cc2ccccc2-c2ccc(CN3C[C@H](C)N[C@H](C)C3)cc2)on1 10.1016/j.bmcl.2008.10.072
CHEMBL516551 196611 0 None - 1 Human 6.0 pEC50 = 6 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 446 7 1 5 4.0 Cc1cc(CC(=O)N(C)Cc2ccccc2-c2ccc(CN3C[C@H](C)N[C@H](C)C3)cc2)on1 10.1016/j.bmcl.2008.10.072
44571990 196475 0 None - 1 Human 6.0 pEC50 = 6 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assay
ChEMBL 533 11 1 4 5.6 COc1cccc(CCN(Cc2ccccc2-c2ccc(CN3CCNCC3)cc2)C(=O)Cc2ccccc2)c1 10.1016/j.bmcl.2008.10.071
CHEMBL515434 196475 0 None - 1 Human 6.0 pEC50 = 6 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assay
ChEMBL 533 11 1 4 5.6 COc1cccc(CCN(Cc2ccccc2-c2ccc(CN3CCNCC3)cc2)C(=O)Cc2ccccc2)c1 10.1016/j.bmcl.2008.10.071
1048 8366 76 None 2 4 Human 6.0 pEC50 = 6 Functional
Agonist activity at motilin receptorAgonist activity at motilin receptor
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1016/j.bmc.2010.08.035
1048 8366 76 None 2 4 Human 6.0 pEC50 = 6 Functional
Agonist activity at motilin receptorAgonist activity at motilin receptor
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1016/j.bmcl.2011.04.078
12560 8366 76 None 2 4 Human 6.0 pEC50 = 6 Functional
Agonist activity at motilin receptorAgonist activity at motilin receptor
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1016/j.bmc.2010.08.035
12560 8366 76 None 2 4 Human 6.0 pEC50 = 6 Functional
Agonist activity at motilin receptorAgonist activity at motilin receptor
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1016/j.bmcl.2011.04.078
1456 8366 76 None 2 4 Human 6.0 pEC50 = 6 Functional
Agonist activity at motilin receptorAgonist activity at motilin receptor
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1016/j.bmc.2010.08.035
1456 8366 76 None 2 4 Human 6.0 pEC50 = 6 Functional
Agonist activity at motilin receptorAgonist activity at motilin receptor
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1016/j.bmcl.2011.04.078
CHEMBL532 8366 76 None 2 4 Human 6.0 pEC50 = 6 Functional
Agonist activity at motilin receptorAgonist activity at motilin receptor
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1016/j.bmc.2010.08.035
CHEMBL532 8366 76 None 2 4 Human 6.0 pEC50 = 6 Functional
Agonist activity at motilin receptorAgonist activity at motilin receptor
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1016/j.bmcl.2011.04.078
DB00199 8366 76 None 2 4 Human 6.0 pEC50 = 6 Functional
Agonist activity at motilin receptorAgonist activity at motilin receptor
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1016/j.bmc.2010.08.035
DB00199 8366 76 None 2 4 Human 6.0 pEC50 = 6 Functional
Agonist activity at motilin receptorAgonist activity at motilin receptor
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1016/j.bmcl.2011.04.078
52944056 24007 0 None - 1 Rabbit 7.0 pEC50 = 7.0 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction
ChEMBL 748 8 5 13 3.2 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@H]1C 10.1016/j.bmcl.2010.08.030
CHEMBL1256554 24007 0 None - 1 Rabbit 7.0 pEC50 = 7.0 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction
ChEMBL 748 8 5 13 3.2 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@H]1C 10.1016/j.bmcl.2010.08.030
168288449 198475 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells
ChEMBL 475 7 1 6 4.0 CC[C@H]1CN(Cc2ccc(N(C)C(=O)[C@H]3CC[C@H](Oc4ccnc(C#N)c4)CC3)cc2C)CCN1 10.1016/j.bmcl.2022.128554
CHEMBL5196819 198475 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells
ChEMBL 475 7 1 6 4.0 CC[C@H]1CN(Cc2ccc(N(C)C(=O)[C@H]3CC[C@H](Oc4ccnc(C#N)c4)CC3)cc2C)CCN1 10.1016/j.bmcl.2022.128554
15984937 7572 31 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay
ChEMBL 424 6 2 4 3.3 C[C@@H]1NCCN(C1)Cc1ccc(cc1)CC(=O)N1CCC(CC1)Nc1cccc(c1)F 10.1021/jm801332q
4035 7572 31 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay
ChEMBL 424 6 2 4 3.3 C[C@@H]1NCCN(C1)Cc1ccc(cc1)CC(=O)N1CCC(CC1)Nc1cccc(c1)F 10.1021/jm801332q
CHEMBL489095 7572 31 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay
ChEMBL 424 6 2 4 3.3 C[C@@H]1NCCN(C1)Cc1ccc(cc1)CC(=O)N1CCC(CC1)Nc1cccc(c1)F 10.1021/jm801332q
DB12567 7572 31 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay
ChEMBL 424 6 2 4 3.3 C[C@@H]1NCCN(C1)Cc1ccc(cc1)CC(=O)N1CCC(CC1)Nc1cccc(c1)F 10.1021/jm801332q
46882713 12503 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 395 4 1 3 4.2 O=S(=O)(Cc1ccc2c(c1)CCNCC2)c1ccc(-c2ccc(F)cc2)cc1 10.1016/j.bmcl.2009.09.027
CHEMBL1078345 12503 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 395 4 1 3 4.2 O=S(=O)(Cc1ccc2c(c1)CCNCC2)c1ccc(-c2ccc(F)cc2)cc1 10.1016/j.bmcl.2009.09.027
15984136 95576 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 425 6 1 4 3.2 C[C@@H]1CN(Cc2ccc(CC(=O)N3CCC(Oc4ccc(F)cc4)CC3)cc2)CCN1 10.6019/CHEMBL2364262
CHEMBL2364263 95576 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 425 6 1 4 3.2 C[C@@H]1CN(Cc2ccc(CC(=O)N3CCC(Oc4ccc(F)cc4)CC3)cc2)CCN1 10.6019/CHEMBL2364262
15984135 95584 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 442 6 2 4 3.4 C[C@@H]1CN(Cc2ccc(CC(=O)N3CCC(Nc4ccc(F)c(F)c4)CC3)cc2)CCN1 10.6019/CHEMBL2364262
CHEMBL2364271 95584 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 442 6 2 4 3.4 C[C@@H]1CN(Cc2ccc(CC(=O)N3CCC(Nc4ccc(F)c(F)c4)CC3)cc2)CCN1 10.6019/CHEMBL2364262
15984138 95586 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 432 6 1 5 3.0 C[C@@H]1CN(Cc2ccc(CC(=O)N3CCC(Oc4ccc(C#N)cc4)CC3)cc2)CCN1 10.6019/CHEMBL2364262
CHEMBL2364273 95586 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 432 6 1 5 3.0 C[C@@H]1CN(Cc2ccc(CC(=O)N3CCC(Oc4ccc(C#N)cc4)CC3)cc2)CCN1 10.6019/CHEMBL2364262
23728769 95621 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 446 6 1 4 4.7 CC(C)N(C(=O)c1ccc(-c2cccc(F)c2)nc1)c1ccc(CN2CCN[C@@H](C)C2)cc1 10.6019/CHEMBL2364262
CHEMBL2364308 95621 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 446 6 1 4 4.7 CC(C)N(C(=O)c1ccc(-c2cccc(F)c2)nc1)c1ccc(CN2CCN[C@@H](C)C2)cc1 10.6019/CHEMBL2364262
54583621 68985 0 None - 1 Rabbit 6.9 pEC50 = 6.9 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 760 8 5 13 3.5 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C3CCC3)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2011.04.078
CHEMBL1778046 68985 0 None - 1 Rabbit 6.9 pEC50 = 6.9 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 760 8 5 13 3.5 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C3CCC3)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2011.04.078
44542067 205512 0 None - 1 Rabbit 6.9 pEC50 = 6.9 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 865 13 7 16 1.5 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NCCO)[C@H](C)[C@@H](O)[C@]1(C)O 10.1021/jm901107f
CHEMBL582871 205512 0 None - 1 Rabbit 6.9 pEC50 = 6.9 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 865 13 7 16 1.5 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NCCO)[C@H](C)[C@@H](O)[C@]1(C)O 10.1021/jm901107f
44542068 205513 0 None - 1 Rabbit 6.9 pEC50 = 6.9 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 905 12 6 16 2.7 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NC2CCOCC2)[C@H](C)[C@@H](O)[C@]1(C)O 10.1021/jm901107f
CHEMBL582872 205513 0 None - 1 Rabbit 6.9 pEC50 = 6.9 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 905 12 6 16 2.7 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NC2CCOCC2)[C@H](C)[C@@H](O)[C@]1(C)O 10.1021/jm901107f
1048 8366 76 None -2 4 Rabbit 5.9 pEC50 = 5.9 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1016/j.bmcl.2010.08.030
12560 8366 76 None -2 4 Rabbit 5.9 pEC50 = 5.9 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1016/j.bmcl.2010.08.030
1456 8366 76 None -2 4 Rabbit 5.9 pEC50 = 5.9 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1016/j.bmcl.2010.08.030
CHEMBL532 8366 76 None -2 4 Rabbit 5.9 pEC50 = 5.9 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1016/j.bmcl.2010.08.030
DB00199 8366 76 None -2 4 Rabbit 5.9 pEC50 = 5.9 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1016/j.bmcl.2010.08.030
1048 8366 76 None -2 4 Rabbit 5.9 pEC50 = 5.9 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1016/j.bmcl.2011.04.078
1048 8366 76 None -2 4 Rabbit 5.9 pEC50 = 5.9 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1021/jm901107f
12560 8366 76 None -2 4 Rabbit 5.9 pEC50 = 5.9 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1016/j.bmcl.2011.04.078
12560 8366 76 None -2 4 Rabbit 5.9 pEC50 = 5.9 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1021/jm901107f
1456 8366 76 None -2 4 Rabbit 5.9 pEC50 = 5.9 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1016/j.bmcl.2011.04.078
1456 8366 76 None -2 4 Rabbit 5.9 pEC50 = 5.9 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1021/jm901107f
CHEMBL532 8366 76 None -2 4 Rabbit 5.9 pEC50 = 5.9 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1016/j.bmcl.2011.04.078
CHEMBL532 8366 76 None -2 4 Rabbit 5.9 pEC50 = 5.9 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1021/jm901107f
DB00199 8366 76 None -2 4 Rabbit 5.9 pEC50 = 5.9 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1016/j.bmcl.2011.04.078
DB00199 8366 76 None -2 4 Rabbit 5.9 pEC50 = 5.9 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1021/jm901107f
46882672 12407 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 357 6 1 3 3.7 CCCCc1ccc(S(=O)(=O)Cc2ccc3c(c2)CCNCC3)cc1 10.1016/j.bmcl.2009.09.027
CHEMBL1077736 12407 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 357 6 1 3 3.7 CCCCc1ccc(S(=O)(=O)Cc2ccc3c(c2)CCNCC3)cc1 10.1016/j.bmcl.2009.09.027
46882711 12501 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 351 3 1 3 3.5 O=S(=O)(Cc1ccc2c(c1)CCNCC2)c1ccc2ccccc2c1 10.1016/j.bmcl.2009.09.027
CHEMBL1078343 12501 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 351 3 1 3 3.5 O=S(=O)(Cc1ccc2c(c1)CCNCC2)c1ccc2ccccc2c1 10.1016/j.bmcl.2009.09.027
54583623 68987 0 None - 1 Rabbit 6.9 pEC50 = 6.9 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 764 9 6 14 2.4 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C[C@H](C)O)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2011.04.078
CHEMBL1778049 68987 0 None - 1 Rabbit 6.9 pEC50 = 6.9 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 764 9 6 14 2.4 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C[C@H](C)O)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2011.04.078
44542518 204941 0 None - 1 Rabbit 6.9 pEC50 = 6.9 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 863 12 6 15 2.9 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NC(C)C)[C@H](C)[C@@H](O)[C@]1(C)O 10.1021/jm901107f
CHEMBL574848 204941 0 None - 1 Rabbit 6.9 pEC50 = 6.9 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 863 12 6 15 2.9 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NC(C)C)[C@H](C)[C@@H](O)[C@]1(C)O 10.1021/jm901107f
16041292 190390 0 None 31 2 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 490 6 2 6 3.9 C[C@H]1CN(Cc2ccc(-n3ccnc3C(=O)N3CCC(Nc4cccc(F)c4)CC3)cc2)C[C@@H](C)N1 10.1016/j.bmcl.2008.10.072
CHEMBL480219 190390 0 None 31 2 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 490 6 2 6 3.9 C[C@H]1CN(Cc2ccc(-n3ccnc3C(=O)N3CCC(Nc4cccc(F)c4)CC3)cc2)C[C@@H](C)N1 10.1016/j.bmcl.2008.10.072
15984137 95585 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 425 6 1 4 3.2 C[C@@H]1CN(Cc2ccc(CC(=O)N3CCC(Oc4cccc(F)c4)CC3)cc2)CCN1 10.6019/CHEMBL2364262
CHEMBL2364272 95585 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 425 6 1 4 3.2 C[C@@H]1CN(Cc2ccc(CC(=O)N3CCC(Oc4cccc(F)c4)CC3)cc2)CCN1 10.6019/CHEMBL2364262
15984184 95587 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 431 6 2 5 3.0 C[C@@H]1CN(Cc2ccc(CC(=O)N3CCC(Nc4ccc(C#N)cc4)CC3)cc2)CCN1 10.6019/CHEMBL2364262
CHEMBL2364274 95587 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 431 6 2 5 3.0 C[C@@H]1CN(Cc2ccc(CC(=O)N3CCC(Nc4ccc(C#N)cc4)CC3)cc2)CCN1 10.6019/CHEMBL2364262
23728771 95627 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 462 8 1 5 4.0 COCCN(C(=O)c1ccc(-c2cccc(F)c2)nc1)c1ccc(CN2CCN[C@@H](C)C2)cc1 10.6019/CHEMBL2364262
CHEMBL2364313 95627 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 462 8 1 5 4.0 COCCN(C(=O)c1ccc(-c2cccc(F)c2)nc1)c1ccc(CN2CCN[C@@H](C)C2)cc1 10.6019/CHEMBL2364262
59262173 95630 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 478 9 1 6 4.1 COCCN(C(=O)c1ccc(Oc2ccc(F)cc2)nc1)c1ccc(CN2CCN[C@@H](C)C2)cc1 10.6019/CHEMBL2364262
CHEMBL2364316 95630 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 478 9 1 6 4.1 COCCN(C(=O)c1ccc(Oc2ccc(F)cc2)nc1)c1ccc(CN2CCN[C@@H](C)C2)cc1 10.6019/CHEMBL2364262
15984243 95646 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 452 6 2 4 4.2 CC(C(=O)N1CCC(Nc2cccc(F)c2)CC1)c1ccc(CN2C[C@H](C)N[C@H](C)C2)cc1 10.6019/CHEMBL2364262
CHEMBL2364332 95646 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 452 6 2 4 4.2 CC(C(=O)N1CCC(Nc2cccc(F)c2)CC1)c1ccc(CN2C[C@H](C)N[C@H](C)C2)cc1 10.6019/CHEMBL2364262
44542965 205548 0 None - 1 Rabbit 6.8 pEC50 = 6.8 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 891 15 6 15 3.7 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCCCCCC(=O)NC)[C@H](C)[C@@H](O)[C@]1(C)O 10.1021/jm901107f
CHEMBL583097 205548 0 None - 1 Rabbit 6.8 pEC50 = 6.8 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 891 15 6 15 3.7 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCCCCCC(=O)NC)[C@H](C)[C@@H](O)[C@]1(C)O 10.1021/jm901107f
44542966 204699 0 None - 1 Rabbit 5.8 pEC50 = 5.8 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 911 12 6 15 3.9 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCc2ccc(C(=O)NC)cc2)[C@H](C)[C@@H](O)[C@]1(C)O 10.1021/jm901107f
CHEMBL572998 204699 0 None - 1 Rabbit 5.8 pEC50 = 5.8 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 911 12 6 15 3.9 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCc2ccc(C(=O)NC)cc2)[C@H](C)[C@@H](O)[C@]1(C)O 10.1021/jm901107f
46882754 12493 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 403 4 1 5 3.3 N#Cc1ccc(-c2ccc(S(=O)(=O)Cc3ccc4c(c3)CCNCC4)cn2)cc1 10.1016/j.bmcl.2009.09.027
CHEMBL1078269 12493 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 403 4 1 5 3.3 N#Cc1ccc(-c2ccc(S(=O)(=O)Cc3ccc4c(c3)CCNCC4)cn2)cc1 10.1016/j.bmcl.2009.09.027
46882794 12520 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 360 5 1 5 2.5 CC(C)Oc1ccc(S(=O)(=O)Cc2ccc3c(c2)CCNCC3)cn1 10.1016/j.bmcl.2009.09.027
CHEMBL1078461 12520 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 360 5 1 5 2.5 CC(C)Oc1ccc(S(=O)(=O)Cc2ccc3c(c2)CCNCC3)cn1 10.1016/j.bmcl.2009.09.027
42623379 95628 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 454 6 2 5 3.9 C[C@H]1CN(Cc2ccc(NS(=O)(=O)c3ccc(-c4ccc(F)cc4)nc3)cc2)C[C@@H](C)N1 10.6019/CHEMBL2364262
CHEMBL2364314 95628 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 454 6 2 5 3.9 C[C@H]1CN(Cc2ccc(NS(=O)(=O)c3ccc(-c4ccc(F)cc4)nc3)cc2)C[C@@H](C)N1 10.6019/CHEMBL2364262
46882623 12623 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 388 4 2 6 1.4 O=S(=O)(Nc1ccc2c(c1)CCNCC2)c1ccc(N2CCOCC2)nc1 10.1016/j.bmcl.2009.09.027
CHEMBL1079260 12623 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 388 4 2 6 1.4 O=S(=O)(Nc1ccc2c(c1)CCNCC2)c1ccc(N2CCOCC2)nc1 10.1016/j.bmcl.2009.09.027
9863611 103705 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 358 6 2 3 3.5 CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCNCC3)cc1 10.1016/j.bmcl.2009.09.027
CHEMBL266018 103705 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 358 6 2 3 3.5 CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCNCC3)cc1 10.1016/j.bmcl.2009.09.027
44571376 190840 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assay
ChEMBL 510 9 2 3 5.8 O=C(NC1CCCCC1)N(CCc1ccccc1)Cc1ccccc1-c1cccc(CN2CCNCC2)c1 10.1016/j.bmcl.2008.10.071
CHEMBL482307 190840 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assay
ChEMBL 510 9 2 3 5.8 O=C(NC1CCCCC1)N(CCc1ccccc1)Cc1ccccc1-c1cccc(CN2CCNCC2)c1 10.1016/j.bmcl.2008.10.071
44542519 205703 0 None - 1 Rabbit 6.8 pEC50 = 6.8 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 903 12 6 15 3.1 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NCC(F)(F)F)[C@H](C)[C@@H](O)[C@]1(C)O 10.1021/jm901107f
CHEMBL584553 205703 0 None - 1 Rabbit 6.8 pEC50 = 6.8 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 903 12 6 15 3.1 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NCC(F)(F)F)[C@H](C)[C@@H](O)[C@]1(C)O 10.1021/jm901107f
54583624 68990 0 None - 1 Rabbit 7.8 pEC50 = 7.8 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 819 11 5 14 3.2 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NC)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2011.04.078
CHEMBL1778052 68990 0 None - 1 Rabbit 7.8 pEC50 = 7.8 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 819 11 5 14 3.2 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NC)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2011.04.078
168274082 197074 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells
ChEMBL 459 6 2 5 4.8 C[C@H]1CN(Cc2ccc(-c3cccnc3N3CCC(Nc4cccc(F)c4)CC3)cc2)CCN1 10.1016/j.bmcl.2022.128554
CHEMBL5175905 197074 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells
ChEMBL 459 6 2 5 4.8 C[C@H]1CN(Cc2ccc(-c3cccnc3N3CCC(Nc4cccc(F)c4)CC3)cc2)CCN1 10.1016/j.bmcl.2022.128554
52941569 24009 0 None - 1 Rabbit 6.8 pEC50 = 6.8 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction
ChEMBL 764 9 6 14 2.2 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C[C@H](C)O)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@H]1C 10.1016/j.bmcl.2010.08.030
CHEMBL1256556 24009 0 None - 1 Rabbit 6.8 pEC50 = 6.8 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction
ChEMBL 764 9 6 14 2.2 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C[C@H](C)O)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@H]1C 10.1016/j.bmcl.2010.08.030
15984134 200050 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay
ChEMBL 424 6 2 4 3.3 C[C@@H]1CN(Cc2ccc(CC(=O)N3CCC(Nc4cccc(F)c4)CC3)cc2)CCN1 10.1021/jm801332q
CHEMBL523933 200050 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay
ChEMBL 424 6 2 4 3.3 C[C@@H]1CN(Cc2ccc(CC(=O)N3CCC(Nc4cccc(F)c4)CC3)cc2)CCN1 10.1021/jm801332q
46882712 12502 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 411 4 1 3 4.7 O=S(=O)(Cc1ccc2c(c1)CCNCC2)c1ccc(-c2ccc(Cl)cc2)cc1 10.1016/j.bmcl.2009.09.027
CHEMBL1078344 12502 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 411 4 1 3 4.7 O=S(=O)(Cc1ccc2c(c1)CCNCC2)c1ccc(-c2ccc(Cl)cc2)cc1 10.1016/j.bmcl.2009.09.027
46882797 12523 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 411 5 2 5 3.6 O=S(=O)(Cc1ccc2c(c1)CCNCC2)c1ccc(Nc2ccc(F)cc2)nc1 10.1016/j.bmcl.2009.09.027
CHEMBL1078464 12523 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 411 5 2 5 3.6 O=S(=O)(Cc1ccc2c(c1)CCNCC2)c1ccc(Nc2ccc(F)cc2)nc1 10.1016/j.bmcl.2009.09.027
44570450 184518 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 534 9 2 5 3.8 Cc1ccc(S(=O)(=O)NCC(=O)N(C)Cc2ccccc2-c2ccc(CN3C[C@H](C)N[C@H](C)C3)cc2)cc1 10.1016/j.bmcl.2008.10.072
CHEMBL464247 184518 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 534 9 2 5 3.8 Cc1ccc(S(=O)(=O)NCC(=O)N(C)Cc2ccccc2-c2ccc(CN3C[C@H](C)N[C@H](C)C3)cc2)cc1 10.1016/j.bmcl.2008.10.072
16041481 185584 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 508 6 2 6 4.5 C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4cccc(C#N)c4)CC3)cc2)C[C@@H](C)N1 10.1016/j.bmcl.2008.10.072
CHEMBL469098 185584 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 508 6 2 6 4.5 C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4cccc(C#N)c4)CC3)cc2)C[C@@H](C)N1 10.1016/j.bmcl.2008.10.072
16040587 186163 0 None 14 2 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 501 6 2 5 4.8 C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1 10.1016/j.bmcl.2008.10.072
CHEMBL473921 186163 0 None 14 2 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 501 6 2 5 4.8 C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1 10.1016/j.bmcl.2008.10.072
15984997 95579 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 425 6 1 4 3.2 C[C@H]1CN(Cc2ccc(CC(=O)N3CCC(Oc4ccc(F)cc4)CC3)cc2)CCN1 10.6019/CHEMBL2364262
CHEMBL2364266 95579 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 425 6 1 4 3.2 C[C@H]1CN(Cc2ccc(CC(=O)N3CCC(Oc4ccc(F)cc4)CC3)cc2)CCN1 10.6019/CHEMBL2364262
59262241 95624 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 495 6 1 4 5.0 C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(C(=O)c4ccc(C(F)(F)F)cc4)cc3)cc2)CCN1 10.6019/CHEMBL2364262
CHEMBL2364310 95624 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 495 6 1 4 5.0 C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(C(=O)c4ccc(C(F)(F)F)cc4)cc3)cc2)CCN1 10.6019/CHEMBL2364262
42623461 95636 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 454 6 2 5 3.8 Cc1cc(NS(=O)(=O)c2cncc(-c3ccc(F)cc3)c2)ccc1CN1CCN[C@@H](C)C1 10.6019/CHEMBL2364262
CHEMBL2364322 95636 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 454 6 2 5 3.8 Cc1cc(NS(=O)(=O)c2cncc(-c3ccc(F)cc3)c2)ccc1CN1CCN[C@@H](C)C1 10.6019/CHEMBL2364262
16041291 95639 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 555 7 2 6 4.5 C[C@H]1CN(Cc2ccc(-c3cccnc3S(=O)(=O)N3CCC(Nc4ccccc4F)CC3)cc2F)C[C@@H](C)N1 10.6019/CHEMBL2364262
CHEMBL2364325 95639 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 555 7 2 6 4.5 C[C@H]1CN(Cc2ccc(-c3cccnc3S(=O)(=O)N3CCC(Nc4ccccc4F)CC3)cc2F)C[C@@H](C)N1 10.6019/CHEMBL2364262
54581677 68991 0 None - 1 Rabbit 6.7 pEC50 = 6.7 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 833 11 4 14 3.5 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)N(C)C)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2011.04.078
CHEMBL1778053 68991 0 None - 1 Rabbit 6.7 pEC50 = 6.7 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 833 11 4 14 3.5 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)N(C)C)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2011.04.078
46882302 12538 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 426 7 1 3 5.2 CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(C2CCCC2)CC3)cc1 10.1016/j.bmcl.2009.09.027
CHEMBL1078558 12538 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 426 7 1 3 5.2 CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(C2CCCC2)CC3)cc1 10.1016/j.bmcl.2009.09.027
46882755 12494 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 439 5 2 5 3.1 O=C(Nc1ccc(F)cc1)c1ccc(S(=O)(=O)Cc2ccc3c(c2)CCNCC3)cn1 10.1016/j.bmcl.2009.09.027
CHEMBL1078270 12494 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 439 5 2 5 3.1 O=C(Nc1ccc(F)cc1)c1ccc(S(=O)(=O)Cc2ccc3c(c2)CCNCC3)cn1 10.1016/j.bmcl.2009.09.027
46882303 12541 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 442 8 1 4 4.3 CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(CC2CCOC2)CC3)cc1 10.1016/j.bmcl.2009.09.027
CHEMBL1078586 12541 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 442 8 1 4 4.3 CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(CC2CCOC2)CC3)cc1 10.1016/j.bmcl.2009.09.027
89723541 197304 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells
ChEMBL 473 6 1 4 4.9 C[C@H]1CN(Cc2ccc(N(C)C(=O)[C@H]3CC[C@H](Oc4ccc(F)cc4)CC3)cc2Cl)CCN1 10.1016/j.bmcl.2022.128554
CHEMBL5179543 197304 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells
ChEMBL 473 6 1 4 4.9 C[C@H]1CN(Cc2ccc(N(C)C(=O)[C@H]3CC[C@H](Oc4ccc(F)cc4)CC3)cc2Cl)CCN1 10.1016/j.bmcl.2022.128554
56960874 197893 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells
ChEMBL 453 6 1 4 4.5 Cc1cc(N(C)C(=O)[C@H]2CC[C@H](Oc3ccc(F)cc3)CC2)ccc1CN1CCN[C@@H](C)C1 10.1016/j.bmcl.2022.128554
CHEMBL5187928 197893 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells
ChEMBL 453 6 1 4 4.5 Cc1cc(N(C)C(=O)[C@H]2CC[C@H](Oc3ccc(F)cc3)CC2)ccc1CN1CCN[C@@H](C)C1 10.1016/j.bmcl.2022.128554
46882458 12750 0 None 31 2 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 438 8 2 4 4.2 CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cc[nH]n2)CC3)cc1 10.1016/j.bmcl.2009.09.027
CHEMBL1080046 12750 0 None 31 2 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 438 8 2 4 4.2 CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cc[nH]n2)CC3)cc1 10.1016/j.bmcl.2009.09.027
44570527 197758 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 500 6 2 4 5.4 C[C@H]1CN(Cc2ccc(-c3ccccc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1 10.1016/j.bmcl.2008.10.072
CHEMBL518618 197758 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 500 6 2 4 5.4 C[C@H]1CN(Cc2ccc(-c3ccccc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1 10.1016/j.bmcl.2008.10.072
15984186 95589 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 474 6 2 4 4.1 C[C@@H]1CN(Cc2ccc(CC(=O)N3CCC(Nc4cccc(C(F)(F)F)c4)CC3)cc2)CCN1 10.6019/CHEMBL2364262
CHEMBL2364276 95589 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 474 6 2 4 4.1 C[C@@H]1CN(Cc2ccc(CC(=O)N3CCC(Nc4cccc(C(F)(F)F)c4)CC3)cc2)CCN1 10.6019/CHEMBL2364262
23729107 95596 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 433 6 1 4 4.7 C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(Oc4cccc(F)c4)cc3)cc2)CCN1 10.6019/CHEMBL2364262
CHEMBL2364283 95596 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 433 6 1 4 4.7 C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(Oc4cccc(F)c4)cc3)cc2)CCN1 10.6019/CHEMBL2364262
16749782 95642 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 464 6 1 7 3.6 C[C@H]1CN(Cc2ccn(-c3cccnc3N3CCC(Oc4cccc(F)c4)CC3)n2)C[C@@H](C)N1 10.6019/CHEMBL2364262
CHEMBL2364328 95642 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 464 6 1 7 3.6 C[C@H]1CN(Cc2ccn(-c3cccnc3N3CCC(Oc4cccc(F)c4)CC3)n2)C[C@@H](C)N1 10.6019/CHEMBL2364262
89723498 198184 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells
ChEMBL 492 9 2 5 5.0 CCOCc1cccc(N[C@H]2CC[C@H](C(=O)N(C)c3ccc(CN4CCN[C@@H](C)C4)c(C)c3)CC2)c1 10.1016/j.bmcl.2022.128554
CHEMBL5192584 198184 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells
ChEMBL 492 9 2 5 5.0 CCOCc1cccc(N[C@H]2CC[C@H](C(=O)N(C)c3ccc(CN4CCN[C@@H](C)C4)c(C)c3)CC2)c1 10.1016/j.bmcl.2022.128554
52942786 23995 0 None - 1 Rabbit 5.7 pEC50 = 5.7 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction
ChEMBL 790 9 6 14 2.7 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC3(C)CC3)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2010.08.030
CHEMBL1256538 23995 0 None - 1 Rabbit 5.7 pEC50 = 5.7 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction
ChEMBL 790 9 6 14 2.7 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC3(C)CC3)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2010.08.030
52943975 23998 0 None - 1 Rabbit 6.7 pEC50 = 6.7 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction
ChEMBL 765 9 7 15 0.9 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCO)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2010.08.030
CHEMBL1256542 23998 0 None - 1 Rabbit 6.7 pEC50 = 6.7 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction
ChEMBL 765 9 7 15 0.9 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCO)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2010.08.030
54586525 68993 0 None - 1 Rabbit 6.7 pEC50 = 6.7 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 765 9 7 15 0.9 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCO)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2011.04.078
CHEMBL1778055 68993 0 None - 1 Rabbit 6.7 pEC50 = 6.7 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 765 9 7 15 0.9 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCO)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2011.04.078
44542215 203911 0 None - 1 Rabbit 5.7 pEC50 = 5.7 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 911 12 6 15 3.9 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCc2cccc(C(=O)NC)c2)[C@H](C)[C@@H](O)[C@]1(C)O 10.1021/jm901107f
CHEMBL567808 203911 0 None - 1 Rabbit 5.7 pEC50 = 5.7 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 911 12 6 15 3.9 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCc2cccc(C(=O)NC)c2)[C@H](C)[C@@H](O)[C@]1(C)O 10.1021/jm901107f
54582662 68988 0 None - 1 Rabbit 7.6 pEC50 = 7.6 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 778 9 6 14 2.7 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC(C)(C)O)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2011.04.078
CHEMBL1778050 68988 0 None - 1 Rabbit 7.6 pEC50 = 7.6 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 778 9 6 14 2.7 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC(C)(C)O)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2011.04.078
168278248 197881 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells
ChEMBL 453 6 1 4 4.5 Cc1cc(CN2CCN[C@@H](C)C2)ccc1N(C)C(=O)[C@H]1CC[C@H](Oc2ccc(F)cc2)CC1 10.1016/j.bmcl.2022.128554
CHEMBL5187776 197881 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells
ChEMBL 453 6 1 4 4.5 Cc1cc(CN2CCN[C@@H](C)C2)ccc1N(C)C(=O)[C@H]1CC[C@H](Oc2ccc(F)cc2)CC1 10.1016/j.bmcl.2022.128554
52942785 23993 0 None - 1 Rabbit 5.6 pEC50 = 5.6 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction
ChEMBL 776 9 6 14 2.5 C=C(C)CN(C)[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)[C@H](O[C@@H]3C[C@@](C)(OC)[C@@H](O)[C@H](C)O3)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)[C@@H](O)[C@H](C)C[C@@]2(C)O)[C@@H]1O 10.1016/j.bmcl.2010.08.030
CHEMBL1256536 23993 0 None - 1 Rabbit 5.6 pEC50 = 5.6 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction
ChEMBL 776 9 6 14 2.5 C=C(C)CN(C)[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)[C@H](O[C@@H]3C[C@@](C)(OC)[C@@H](O)[C@H](C)O3)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)[C@@H](O)[C@H](C)C[C@@]2(C)O)[C@@H]1O 10.1016/j.bmcl.2010.08.030
16088034 205545 0 None - 1 Rabbit 7.6 pEC50 = 7.6 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 899 12 6 17 2.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)Nc2ccncn2)[C@H](C)[C@@H](O)[C@]1(C)O 10.1021/jm901107f
CHEMBL583094 205545 0 None - 1 Rabbit 7.6 pEC50 = 7.6 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 899 12 6 17 2.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)Nc2ccncn2)[C@H](C)[C@@H](O)[C@]1(C)O 10.1021/jm901107f
15984241 186302 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay
ChEMBL 438 7 2 4 3.7 C[C@H]1CN(Cc2ccc(CCC(=O)N3CCC(Nc4cccc(F)c4)CC3)cc2)CCN1 10.1021/jm801332q
CHEMBL474130 186302 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay
ChEMBL 438 7 2 4 3.7 C[C@H]1CN(Cc2ccc(CCC(=O)N3CCC(Nc4cccc(F)c4)CC3)cc2)CCN1 10.1021/jm801332q
46882714 12463 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 413 4 1 3 4.3 O=S(=O)(Cc1ccc2c(c1)CCNCC2)c1ccc(-c2ccc(F)c(F)c2)cc1 10.1016/j.bmcl.2009.09.027
CHEMBL1077991 12463 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 413 4 1 3 4.3 O=S(=O)(Cc1ccc2c(c1)CCNCC2)c1ccc(-c2ccc(F)c(F)c2)cc1 10.1016/j.bmcl.2009.09.027
15984998 95580 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 425 6 1 4 3.2 C[C@H]1CN(Cc2ccc(CC(=O)N3CCC(Oc4cccc(F)c4)CC3)cc2)CCN1 10.6019/CHEMBL2364262
CHEMBL2364267 95580 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 425 6 1 4 3.2 C[C@H]1CN(Cc2ccc(CC(=O)N3CCC(Oc4cccc(F)c4)CC3)cc2)CCN1 10.6019/CHEMBL2364262
15984187 95583 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 454 7 2 5 3.3 COc1cc(CC(=O)N2CCC(Nc3cccc(F)c3)CC2)ccc1CN1CCN[C@@H](C)C1 10.6019/CHEMBL2364262
CHEMBL2364270 95583 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 454 7 2 5 3.3 COc1cc(CC(=O)N2CCC(Nc3cccc(F)c3)CC2)ccc1CN1CCN[C@@H](C)C1 10.6019/CHEMBL2364262
16749728 95638 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 479 6 2 6 5.2 C[C@H]1CN(Cc2ccc(-c3cccnc3N3CCC(Nc4ccc(F)cc4)CC3)s2)C[C@@H](C)N1 10.6019/CHEMBL2364262
CHEMBL2364324 95638 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 479 6 2 6 5.2 C[C@H]1CN(Cc2ccc(-c3cccnc3N3CCC(Nc4ccc(F)cc4)CC3)s2)C[C@@H](C)N1 10.6019/CHEMBL2364262
15984319 95647 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 466 6 2 4 4.4 C[C@H]1CN(Cc2ccc(C(C)(C)C(=O)N3CCC(Nc4cccc(F)c4)CC3)cc2)C[C@@H](C)N1 10.6019/CHEMBL2364262
CHEMBL2364333 95647 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 466 6 2 4 4.4 C[C@H]1CN(Cc2ccc(C(C)(C)C(=O)N3CCC(Nc4cccc(F)c4)CC3)cc2)C[C@@H](C)N1 10.6019/CHEMBL2364262
52948855 24004 0 None - 1 Rabbit 5.6 pEC50 = 5.6 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction
ChEMBL 795 10 8 16 0.3 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC(O)CO)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2010.08.030
CHEMBL1256548 24004 0 None - 1 Rabbit 5.6 pEC50 = 5.6 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction
ChEMBL 795 10 8 16 0.3 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC(O)CO)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2010.08.030
44593551 44541 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 549 12 1 5 5.4 COc1cccc(CCN(Cc2ccccc2-c2ccc(CN3CCNCC3)cc2)C(=O)COc2ccccc2)c1 10.1016/j.bmcl.2008.10.072
CHEMBL14581 44541 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 549 12 1 5 5.4 COc1cccc(CCN(Cc2ccccc2-c2ccc(CN3CCNCC3)cc2)C(=O)COc2ccccc2)c1 10.1016/j.bmcl.2008.10.072
44570451 197283 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 421 8 1 3 4.9 CC(C)CCC(=O)N(C)Cc1ccccc1-c1ccc(CN2C[C@H](C)N[C@H](C)C2)cc1 10.1016/j.bmcl.2008.10.072
CHEMBL517934 197283 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 421 8 1 3 4.9 CC(C)CCC(=O)N(C)Cc1ccccc1-c1ccc(CN2C[C@H](C)N[C@H](C)C2)cc1 10.1016/j.bmcl.2008.10.072
44593551 44541 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assay
ChEMBL 549 12 1 5 5.4 COc1cccc(CCN(Cc2ccccc2-c2ccc(CN3CCNCC3)cc2)C(=O)COc2ccccc2)c1 10.1016/j.bmcl.2008.10.071
CHEMBL14581 44541 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assay
ChEMBL 549 12 1 5 5.4 COc1cccc(CCN(Cc2ccccc2-c2ccc(CN3CCNCC3)cc2)C(=O)COc2ccccc2)c1 10.1016/j.bmcl.2008.10.071
46882350 12578 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 454 8 1 4 5.5 CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cccs2)CC3)cc1 10.1016/j.bmcl.2009.09.027
CHEMBL1078882 12578 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 454 8 1 4 5.5 CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cccs2)CC3)cc1 10.1016/j.bmcl.2009.09.027
46882624 12624 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 372 6 1 3 3.5 CCCCc1ccc(S(=O)(=O)N(C)c2ccc3c(c2)CCNCC3)cc1 10.1016/j.bmcl.2009.09.027
CHEMBL1079261 12624 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 372 6 1 3 3.5 CCCCc1ccc(S(=O)(=O)N(C)c2ccc3c(c2)CCNCC3)cc1 10.1016/j.bmcl.2009.09.027
46882625 12625 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 388 4 2 6 1.4 O=S(=O)(Nc1ccc(N2CCOCC2)nc1)c1ccc2c(c1)CCNCC2 10.1016/j.bmcl.2009.09.027
CHEMBL1079262 12625 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 388 4 2 6 1.4 O=S(=O)(Nc1ccc(N2CCOCC2)nc1)c1ccc2c(c1)CCNCC2 10.1016/j.bmcl.2009.09.027
46882460 13082 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 396 6 2 4 3.0 O=S(=O)(Cc1ccccc1)Nc1ccc2c(c1)CCN(Cc1cc[nH]n1)CC2 10.1016/j.bmcl.2009.09.027
CHEMBL1081859 13082 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 396 6 2 4 3.0 O=S(=O)(Cc1ccccc1)Nc1ccc2c(c1)CCN(Cc1cc[nH]n1)CC2 10.1016/j.bmcl.2009.09.027
44570013 183646 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 526 7 3 6 3.7 C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(C(N)=O)cc4)CC3)cc2)C[C@@H](C)N1 10.1016/j.bmcl.2008.10.072
CHEMBL461446 183646 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 526 7 3 6 3.7 C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(C(N)=O)cc4)CC3)cc2)C[C@@H](C)N1 10.1016/j.bmcl.2008.10.072
44570608 197513 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 493 6 2 5 4.1 C[C@H]1CN(Cc2ccc(N3CCCC3C(=O)N3CCC(Nc4cccc(F)c4)CC3)cc2)C[C@@H](C)N1 10.1016/j.bmcl.2008.10.072
CHEMBL518261 197513 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 493 6 2 5 4.1 C[C@H]1CN(Cc2ccc(N3CCCC3C(=O)N3CCC(Nc4cccc(F)c4)CC3)cc2)C[C@@H](C)N1 10.1016/j.bmcl.2008.10.072
52947632 23991 0 None - 1 Rabbit 6.6 pEC50 = 6.6 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction
ChEMBL 764 8 6 14 2.4 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2010.08.030
CHEMBL1256534 23991 0 None - 1 Rabbit 6.6 pEC50 = 6.6 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction
ChEMBL 764 8 6 14 2.4 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2010.08.030
44542667 205699 0 None - 1 Rabbit 6.6 pEC50 = 6.6 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 764 8 6 14 2.4 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2011.04.078
44542667 205699 0 None - 1 Rabbit 6.6 pEC50 = 6.6 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 764 8 6 14 2.4 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1021/jm901107f
CHEMBL584549 205699 0 None - 1 Rabbit 6.6 pEC50 = 6.6 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 764 8 6 14 2.4 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2011.04.078
CHEMBL584549 205699 0 None - 1 Rabbit 6.6 pEC50 = 6.6 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 764 8 6 14 2.4 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1021/jm901107f
44542964 205547 0 None - 1 Rabbit 6.6 pEC50 = 6.6 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 877 14 6 15 3.3 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCCCCC(=O)NC)[C@H](C)[C@@H](O)[C@]1(C)O 10.1021/jm901107f
CHEMBL583096 205547 0 None - 1 Rabbit 6.6 pEC50 = 6.6 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 877 14 6 15 3.3 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCCCCC(=O)NC)[C@H](C)[C@@H](O)[C@]1(C)O 10.1021/jm901107f
44542520 205511 0 None - 1 Rabbit 7.6 pEC50 = 7.6 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 875 12 6 15 3.0 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NC2CCC2)[C@H](C)[C@@H](O)[C@]1(C)O 10.1021/jm901107f
CHEMBL582870 205511 0 None - 1 Rabbit 7.6 pEC50 = 7.6 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 875 12 6 15 3.0 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NC2CCC2)[C@H](C)[C@@H](O)[C@]1(C)O 10.1021/jm901107f
52942801 24010 0 None - 1 Rabbit 6.6 pEC50 = 6.6 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction
ChEMBL 764 9 6 14 2.2 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C[C@@H](C)O)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@H]1C 10.1016/j.bmcl.2010.08.030
CHEMBL1256557 24010 0 None - 1 Rabbit 6.6 pEC50 = 6.6 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction
ChEMBL 764 9 6 14 2.2 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C[C@@H](C)O)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@H]1C 10.1016/j.bmcl.2010.08.030
46882395 12615 0 None 1 2 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 452 8 2 4 4.5 CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2[nH]cnc2C)CC3)cc1 10.1016/j.bmcl.2009.09.027
CHEMBL1079186 12615 0 None 1 2 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 452 8 2 4 4.5 CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2[nH]cnc2C)CC3)cc1 10.1016/j.bmcl.2009.09.027
44570411 185145 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 473 8 1 4 5.3 C[C@H]1CN(Cc2ccc(-c3ccccc3CN(C)C(=O)CSc3ccccc3)cc2)C[C@@H](C)N1 10.1016/j.bmcl.2008.10.072
CHEMBL465271 185145 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 473 8 1 4 5.3 C[C@H]1CN(Cc2ccc(-c3ccccc3CN(C)C(=O)CSc3ccccc3)cc2)C[C@@H](C)N1 10.1016/j.bmcl.2008.10.072
15984185 95588 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 431 6 2 5 3.0 C[C@@H]1CN(Cc2ccc(CC(=O)N3CCC(Nc4cccc(C#N)c4)CC3)cc2)CCN1 10.6019/CHEMBL2364262
CHEMBL2364275 95588 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 431 6 2 5 3.0 C[C@@H]1CN(Cc2ccc(CC(=O)N3CCC(Nc4cccc(C#N)c4)CC3)cc2)CCN1 10.6019/CHEMBL2364262
23728695 95608 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 441 6 1 6 3.8 C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(Oc4cccc(C#N)c4)nc3)cc2)CCN1 10.6019/CHEMBL2364262
CHEMBL2364295 95608 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 441 6 1 6 3.8 C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(Oc4cccc(C#N)c4)nc3)cc2)CCN1 10.6019/CHEMBL2364262
23728694 95611 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 452 6 1 5 4.2 C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(Oc4ccc(F)cc4)nc3)c(F)c2)CCN1 10.6019/CHEMBL2364262
CHEMBL2364298 95611 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 452 6 1 5 4.2 C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(Oc4ccc(F)cc4)nc3)c(F)c2)CCN1 10.6019/CHEMBL2364262
16040587 186163 0 None 14 2 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay
ChEMBL 501 6 2 5 4.8 C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1 10.1021/jm801332q
CHEMBL473921 186163 0 None 14 2 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay
ChEMBL 501 6 2 5 4.8 C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1 10.1021/jm801332q
15984939 193632 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay
ChEMBL 431 6 2 5 3.0 C[C@H]1CN(Cc2ccc(CC(=O)N3CCC(Nc4cccc(C#N)c4)CC3)cc2)CCN1 10.1021/jm801332q
CHEMBL489480 193632 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay
ChEMBL 431 6 2 5 3.0 C[C@H]1CN(Cc2ccc(CC(=O)N3CCC(Nc4cccc(C#N)c4)CC3)cc2)CCN1 10.1021/jm801332q
46882522 12484 0 None 39 2 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 440 7 2 5 3.6 CC(C)Oc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cc[nH]n2)CC3)cc1 10.1016/j.bmcl.2009.09.027
CHEMBL1078208 12484 0 None 39 2 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 440 7 2 5 3.6 CC(C)Oc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cc[nH]n2)CC3)cc1 10.1016/j.bmcl.2009.09.027
16040939 197484 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 519 6 2 5 4.9 C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2F)C[C@@H](C)N1 10.1016/j.bmcl.2008.10.072
CHEMBL518229 197484 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 519 6 2 5 4.9 C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2F)C[C@@H](C)N1 10.1016/j.bmcl.2008.10.072
52946425 24008 0 None - 1 Rabbit 6.5 pEC50 = 6.5 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction
ChEMBL 760 8 5 13 3.4 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C3CCC3)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@H]1C 10.1016/j.bmcl.2010.08.030
CHEMBL1256555 24008 0 None - 1 Rabbit 6.5 pEC50 = 6.5 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction
ChEMBL 760 8 5 13 3.4 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C3CCC3)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@H]1C 10.1016/j.bmcl.2010.08.030
44541929 205510 0 None - 1 Rabbit 7.5 pEC50 = 7.5 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 861 12 6 15 2.7 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NC2CC2)[C@H](C)[C@@H](O)[C@]1(C)O 10.1021/jm901107f
CHEMBL582869 205510 0 None - 1 Rabbit 7.5 pEC50 = 7.5 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 861 12 6 15 2.7 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NC2CC2)[C@H](C)[C@@H](O)[C@]1(C)O 10.1021/jm901107f
15984242 193592 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay
ChEMBL 452 6 2 4 4.2 CC(C(=O)N1CCC(Nc2ccc(F)cc2)CC1)c1ccc(CN2C[C@H](C)N[C@H](C)C2)cc1 10.1021/jm801332q
CHEMBL489297 193592 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay
ChEMBL 452 6 2 4 4.2 CC(C(=O)N1CCC(Nc2ccc(F)cc2)CC1)c1ccc(CN2C[C@H](C)N[C@H](C)C2)cc1 10.1021/jm801332q
15984318 193631 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay
ChEMBL 466 6 2 4 4.4 C[C@H]1CN(Cc2ccc(C(C)(C)C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1 10.1021/jm801332q
CHEMBL489479 193631 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay
ChEMBL 466 6 2 4 4.4 C[C@H]1CN(Cc2ccc(C(C)(C)C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1 10.1021/jm801332q
46882583 12528 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 453 5 2 6 2.6 CN1CCOc2cc(S(=O)(=O)Nc3ccc4c(c3)CCN(Cc3cc[nH]n3)CC4)ccc21 10.1016/j.bmcl.2009.09.027
CHEMBL1078491 12528 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 453 5 2 6 2.6 CN1CCOc2cc(S(=O)(=O)Nc3ccc4c(c3)CCN(Cc3cc[nH]n3)CC4)ccc21 10.1016/j.bmcl.2009.09.027
44570365 184947 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 475 8 1 4 4.7 C[C@H]1CN(Cc2ccc(-c3ccccc3CN(C)C(=O)COc3ccc(F)cc3)cc2)C[C@@H](C)N1 10.1016/j.bmcl.2008.10.072
CHEMBL464909 184947 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 475 8 1 4 4.7 C[C@H]1CN(Cc2ccc(-c3ccccc3CN(C)C(=O)COc3ccc(F)cc3)cc2)C[C@@H](C)N1 10.1016/j.bmcl.2008.10.072
15984994 95577 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 431 6 2 5 3.0 C[C@H]1CN(Cc2ccc(CC(=O)N3CCC(Nc4ccc(C#N)cc4)CC3)cc2)CCN1 10.6019/CHEMBL2364262
CHEMBL2364264 95577 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 431 6 2 5 3.0 C[C@H]1CN(Cc2ccc(CC(=O)N3CCC(Nc4ccc(C#N)cc4)CC3)cc2)CCN1 10.6019/CHEMBL2364262
23728774 95616 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 435 6 1 6 3.5 C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(Oc4ccc(F)cc4)nc3)nc2)CCN1 10.6019/CHEMBL2364262
CHEMBL2364303 95616 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 435 6 1 6 3.5 C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(Oc4ccc(F)cc4)nc3)nc2)CCN1 10.6019/CHEMBL2364262
52950053 23994 0 None - 1 Rabbit 6.5 pEC50 = 6.5 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction
ChEMBL 776 9 6 14 2.4 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC3CC3)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2010.08.030
CHEMBL1256537 23994 0 None - 1 Rabbit 6.5 pEC50 = 6.5 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction
ChEMBL 776 9 6 14 2.4 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC3CC3)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2010.08.030
46882710 12500 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 357 3 1 3 3.6 CC(C)(C)c1ccc(S(=O)(=O)Cc2ccc3c(c2)CCNCC3)cc1 10.1016/j.bmcl.2009.09.027
CHEMBL1078342 12500 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 357 3 1 3 3.6 CC(C)(C)c1ccc(S(=O)(=O)Cc2ccc3c(c2)CCNCC3)cc1 10.1016/j.bmcl.2009.09.027
46882457 12723 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 452 8 1 5 4.2 CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cncn2C)CC3)cc1 10.1016/j.bmcl.2009.09.027
CHEMBL1079868 12723 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 452 8 1 5 4.2 CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cncn2C)CC3)cc1 10.1016/j.bmcl.2009.09.027
44572092 187325 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay
ChEMBL 487 14 0 4 5.0 COCCCN(Cc1ccccc1-c1ccc(CN(C)CCN(C)C)cc1)C(=O)Cc1ccccc1 10.1016/j.bmcl.2008.10.071
CHEMBL475380 187325 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay
ChEMBL 487 14 0 4 5.0 COCCCN(Cc1ccccc1-c1ccc(CN(C)CCN(C)C)cc1)C(=O)Cc1ccccc1 10.1016/j.bmcl.2008.10.071
89872388 197266 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells
ChEMBL 467 7 1 4 4.9 CC[C@H]1CN(Cc2ccc(N(C)C(=O)[C@H]3CC[C@H](Oc4ccc(F)cc4)CC3)cc2C)CCN1 10.1016/j.bmcl.2022.128554
CHEMBL5179060 197266 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells
ChEMBL 467 7 1 4 4.9 CC[C@H]1CN(Cc2ccc(N(C)C(=O)[C@H]3CC[C@H](Oc4ccc(F)cc4)CC3)cc2C)CCN1 10.1016/j.bmcl.2022.128554
52941620 23996 0 None - 1 Rabbit 6.5 pEC50 = 6.5 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction
ChEMBL 776 8 6 14 2.5 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C3CCC3)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2010.08.030
CHEMBL1256539 23996 0 None - 1 Rabbit 6.5 pEC50 = 6.5 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction
ChEMBL 776 8 6 14 2.5 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C3CCC3)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2010.08.030
54587558 68992 0 None - 1 Rabbit 6.5 pEC50 = 6.5 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 776 8 6 14 2.5 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C3CCC3)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2011.04.078
CHEMBL1778054 68992 0 None - 1 Rabbit 6.5 pEC50 = 6.5 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 776 8 6 14 2.5 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C3CCC3)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2011.04.078
54580662 68989 0 None - 1 Rabbit 7.4 pEC50 = 7.4 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 805 11 5 14 2.9 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(N)=O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2011.04.078
CHEMBL1778051 68989 0 None - 1 Rabbit 7.4 pEC50 = 7.4 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 805 11 5 14 2.9 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(N)=O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2011.04.078
52942788 24001 0 None - 1 Rabbit 6.4 pEC50 = 6.4 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction
ChEMBL 780 9 7 15 1.3 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C[C@H](C)O)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2010.08.030
CHEMBL1256545 24001 0 None - 1 Rabbit 6.4 pEC50 = 6.4 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction
ChEMBL 780 9 7 15 1.3 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C[C@H](C)O)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2010.08.030
54584626 69000 0 None - 1 Rabbit 6.4 pEC50 = 6.4 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 780 9 7 15 1.3 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C[C@H](C)O)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2011.04.078
CHEMBL1778154 69000 0 None - 1 Rabbit 6.4 pEC50 = 6.4 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 780 9 7 15 1.3 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C[C@H](C)O)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2011.04.078
52946408 23992 0 None - 1 Rabbit 6.4 pEC50 = 6.4 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction
ChEMBL 778 9 6 14 2.6 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2010.08.030
CHEMBL1256535 23992 0 None - 1 Rabbit 6.4 pEC50 = 6.4 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction
ChEMBL 778 9 6 14 2.6 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2010.08.030
52942789 24005 0 None - 1 Rabbit 5.4 pEC50 = 5.4 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction
ChEMBL 767 9 6 14 1.9 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCF)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2010.08.030
CHEMBL1256549 24005 0 None - 1 Rabbit 5.4 pEC50 = 5.4 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction
ChEMBL 767 9 6 14 1.9 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCF)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2010.08.030
15604512 186965 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay
ChEMBL 438 6 2 4 3.7 C[C@H]1CN(Cc2ccc(CC(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1 10.1021/jm801332q
CHEMBL474934 186965 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay
ChEMBL 438 6 2 4 3.7 C[C@H]1CN(Cc2ccc(CC(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1 10.1021/jm801332q
46882795 12521 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 374 6 1 5 2.8 CC(C)COc1ccc(S(=O)(=O)Cc2ccc3c(c2)CCNCC3)cn1 10.1016/j.bmcl.2009.09.027
CHEMBL1078462 12521 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 374 6 1 5 2.8 CC(C)COc1ccc(S(=O)(=O)Cc2ccc3c(c2)CCNCC3)cn1 10.1016/j.bmcl.2009.09.027
46882520 12628 0 None 1 2 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 430 5 2 4 3.8 Cc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cc[nH]n2)CC3)cc1Cl 10.1016/j.bmcl.2009.09.027
CHEMBL1079311 12628 0 None 1 2 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 430 5 2 4 3.8 Cc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cc[nH]n2)CC3)cc1Cl 10.1016/j.bmcl.2009.09.027
23729060 95591 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 417 5 1 3 4.6 C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(-c4ccc(F)cc4)cc3)cc2)CCN1 10.6019/CHEMBL2364262
CHEMBL2364278 95591 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 417 5 1 3 4.6 C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(-c4ccc(F)cc4)cc3)cc2)CCN1 10.6019/CHEMBL2364262
23728733 95617 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 445 6 1 5 3.2 C[C@H]1CN(Cc2ccc(N(C)C(=O)C3CCN(Cc4cccc(C#N)c4)CC3)cc2)CCN1 10.6019/CHEMBL2364262
CHEMBL2364304 95617 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 445 6 1 5 3.2 C[C@H]1CN(Cc2ccc(N(C)C(=O)C3CCN(Cc4cccc(C#N)c4)CC3)cc2)CCN1 10.6019/CHEMBL2364262
23728840 95622 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 425 5 1 5 3.7 C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(-c4cccc(C#N)c4)cn3)cc2)CCN1 10.6019/CHEMBL2364262
CHEMBL2364309 95622 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 425 5 1 5 3.7 C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(-c4cccc(C#N)c4)cn3)cc2)CCN1 10.6019/CHEMBL2364262
15984239 95645 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 452 7 2 4 4.0 C[C@H]1CN(Cc2ccc(CCC(=O)N3CCC(Nc4cccc(F)c4)CC3)cc2)C[C@@H](C)N1 10.6019/CHEMBL2364262
CHEMBL2364331 95645 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 452 7 2 4 4.0 C[C@H]1CN(Cc2ccc(CCC(=O)N3CCC(Nc4cccc(F)c4)CC3)cc2)C[C@@H](C)N1 10.6019/CHEMBL2364262
44571375 196454 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay
ChEMBL 539 10 2 3 7.0 COc1cccc(CCN(Cc2ccccc2-c2ccc(CC3CCNCC3)cc2)C(=O)NC2CCCCC2)c1 10.1016/j.bmcl.2008.10.071
CHEMBL515275 196454 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay
ChEMBL 539 10 2 3 7.0 COc1cccc(CCN(Cc2ccccc2-c2ccc(CC3CCNCC3)cc2)C(=O)NC2CCCCC2)c1 10.1016/j.bmcl.2008.10.071
44593552 185087 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 487 12 1 5 4.2 COCCCN(Cc1ccccc1-c1ccc(CN2CCNCC2)cc1)C(=O)COc1ccccc1 10.1016/j.bmcl.2008.10.072
CHEMBL465104 185087 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 487 12 1 5 4.2 COCCCN(Cc1ccccc1-c1ccc(CN2CCNCC2)cc1)C(=O)COc1ccccc1 10.1016/j.bmcl.2008.10.072
44570568 190681 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 507 6 2 6 4.8 C[C@H]1CN(Cc2cnc(-c3ccccc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)s2)C[C@@H](C)N1 10.1016/j.bmcl.2008.10.072
CHEMBL481192 190681 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 507 6 2 6 4.8 C[C@H]1CN(Cc2cnc(-c3ccccc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)s2)C[C@@H](C)N1 10.1016/j.bmcl.2008.10.072
44593552 185087 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assay
ChEMBL 487 12 1 5 4.2 COCCCN(Cc1ccccc1-c1ccc(CN2CCNCC2)cc1)C(=O)COc1ccccc1 10.1016/j.bmcl.2008.10.071
CHEMBL465104 185087 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assay
ChEMBL 487 12 1 5 4.2 COCCCN(Cc1ccccc1-c1ccc(CN2CCNCC2)cc1)C(=O)COc1ccccc1 10.1016/j.bmcl.2008.10.071
53322109 63043 0 None 1 2 Human 8.4 pEC50 = 8.4 Functional
In vitro effective concentration towards human motilin receptorIn vitro effective concentration towards human motilin receptor
ChEMBL 697 8 2 11 5.2 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@H]1C 10.1021/jm0304865
CHEMBL1628277 63043 0 None 1 2 Human 8.4 pEC50 = 8.4 Functional
In vitro effective concentration towards human motilin receptorIn vitro effective concentration towards human motilin receptor
ChEMBL 697 8 2 11 5.2 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@H]1C 10.1021/jm0304865
89723511 196823 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells
ChEMBL 507 8 2 5 4.7 Cc1cc(N(C)C(=O)[C@H]2CC[C@H](Oc3cccc(CC(C)(C)O)c3)CC2)ccc1CN1CCN[C@@H](C)C1 10.1016/j.bmcl.2022.128554
CHEMBL5171964 196823 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells
ChEMBL 507 8 2 5 4.7 Cc1cc(N(C)C(=O)[C@H]2CC[C@H](Oc3cccc(CC(C)(C)O)c3)CC2)ccc1CN1CCN[C@@H](C)C1 10.1016/j.bmcl.2022.128554
56960875 197650 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells
ChEMBL 454 6 1 5 3.9 Cc1cc(N(C)C(=O)[C@H]2CC[C@H](Oc3ccc(F)cn3)CC2)ccc1CN1CCN[C@@H](C)C1 10.1016/j.bmcl.2022.128554
CHEMBL5184722 197650 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells
ChEMBL 454 6 1 5 3.9 Cc1cc(N(C)C(=O)[C@H]2CC[C@H](Oc3ccc(F)cn3)CC2)ccc1CN1CCN[C@@H](C)C1 10.1016/j.bmcl.2022.128554
56961016 198488 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells
ChEMBL 479 8 2 5 3.9 Cc1cc(N(C)C(=O)[C@H]2CC[C@H](Oc3cccc(CCO)c3)CC2)ccc1CN1CCN[C@@H](C)C1 10.1016/j.bmcl.2022.128554
CHEMBL5196982 198488 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells
ChEMBL 479 8 2 5 3.9 Cc1cc(N(C)C(=O)[C@H]2CC[C@H](Oc3cccc(CCO)c3)CC2)ccc1CN1CCN[C@@H](C)C1 10.1016/j.bmcl.2022.128554
1048 8366 76 None 2 4 Human 6.4 pEC50 = 6.4 Functional
In vitro effective concentration towards human motilin receptorIn vitro effective concentration towards human motilin receptor
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1021/jm0304865
12560 8366 76 None 2 4 Human 6.4 pEC50 = 6.4 Functional
In vitro effective concentration towards human motilin receptorIn vitro effective concentration towards human motilin receptor
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1021/jm0304865
1456 8366 76 None 2 4 Human 6.4 pEC50 = 6.4 Functional
In vitro effective concentration towards human motilin receptorIn vitro effective concentration towards human motilin receptor
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1021/jm0304865
CHEMBL532 8366 76 None 2 4 Human 6.4 pEC50 = 6.4 Functional
In vitro effective concentration towards human motilin receptorIn vitro effective concentration towards human motilin receptor
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1021/jm0304865
DB00199 8366 76 None 2 4 Human 6.4 pEC50 = 6.4 Functional
In vitro effective concentration towards human motilin receptorIn vitro effective concentration towards human motilin receptor
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1021/jm0304865
44292287 194359 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
In vitro effective concentration towards human motilin receptorIn vitro effective concentration towards human motilin receptor
ChEMBL 546 7 3 10 -0.0 NC(=O)[C@@H](Cc1ccccc1)NC(=O)C1C=CC2(CCNCC2)n2c(=O)n(Cc3ccc4c(c3)OCO4)c(=O)n21 10.1021/jm0304865
CHEMBL49464 194359 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
In vitro effective concentration towards human motilin receptorIn vitro effective concentration towards human motilin receptor
ChEMBL 546 7 3 10 -0.0 NC(=O)[C@@H](Cc1ccccc1)NC(=O)C1C=CC2(CCNCC2)n2c(=O)n(Cc3ccc4c(c3)OCO4)c(=O)n21 10.1021/jm0304865
89723443 197296 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells
ChEMBL 439 6 1 4 4.1 Cc1cc(N(C)C(=O)[C@H]2CC[C@H](Oc3ccc(F)cc3)CC2)ccc1CN1CCNCC1 10.1016/j.bmcl.2022.128554
CHEMBL5179463 197296 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells
ChEMBL 439 6 1 4 4.1 Cc1cc(N(C)C(=O)[C@H]2CC[C@H](Oc3ccc(F)cc3)CC2)ccc1CN1CCNCC1 10.1016/j.bmcl.2022.128554
52950055 24002 0 None - 1 Rabbit 6.3 pEC50 = 6.3 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction
ChEMBL 780 9 7 15 1.3 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C[C@@H](C)O)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2010.08.030
CHEMBL1256546 24002 0 None - 1 Rabbit 6.3 pEC50 = 6.3 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction
ChEMBL 780 9 7 15 1.3 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C[C@@H](C)O)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2010.08.030
46882753 12492 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 396 4 1 4 3.6 O=S(=O)(Cc1ccc2c(c1)CCNCC2)c1ccc(-c2ccc(F)cc2)nc1 10.1016/j.bmcl.2009.09.027
CHEMBL1078268 12492 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 396 4 1 4 3.6 O=S(=O)(Cc1ccc2c(c1)CCNCC2)c1ccc(-c2ccc(F)cc2)nc1 10.1016/j.bmcl.2009.09.027
46882582 12527 0 None 125 2 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 466 5 2 5 3.9 CC1(C)CCc2cc(S(=O)(=O)Nc3ccc4c(c3)CCN(Cc3cc[nH]n3)CC4)ccc2O1 10.1016/j.bmcl.2009.09.027
CHEMBL1078490 12527 0 None 125 2 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 466 5 2 5 3.9 CC1(C)CCc2cc(S(=O)(=O)Nc3ccc4c(c3)CCN(Cc3cc[nH]n3)CC4)ccc2O1 10.1016/j.bmcl.2009.09.027
16041121 185068 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 531 7 2 6 4.8 COc1cc(-c2cccnc2C(=O)N2CCC(Nc3ccc(F)cc3)CC2)ccc1CN1C[C@H](C)N[C@H](C)C1 10.1016/j.bmcl.2008.10.072
CHEMBL465095 185068 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 531 7 2 6 4.8 COc1cc(-c2cccnc2C(=O)N2CCC(Nc3ccc(F)cc3)CC2)ccc1CN1C[C@H](C)N[C@H](C)C1 10.1016/j.bmcl.2008.10.072
44570491 189839 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 482 6 2 4 5.3 C[C@H]1CN(Cc2ccc(-c3ccccc3C(=O)N3CCC(Nc4ccccc4)CC3)cc2)C[C@@H](C)N1 10.1016/j.bmcl.2008.10.072
CHEMBL479419 189839 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 482 6 2 4 5.3 C[C@H]1CN(Cc2ccc(-c3ccccc3C(=O)N3CCC(Nc4ccccc4)CC3)cc2)C[C@@H](C)N1 10.1016/j.bmcl.2008.10.072
23729063 95592 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 438 6 1 4 3.5 C[C@H]1CN(Cc2ccc(N(C)C(=O)C3CCN(Cc4cccc(F)c4)CC3)cc2)CCN1 10.6019/CHEMBL2364262
CHEMBL2364279 95592 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 438 6 1 4 3.5 C[C@H]1CN(Cc2ccc(N(C)C(=O)C3CCN(Cc4cccc(F)c4)CC3)cc2)CCN1 10.6019/CHEMBL2364262
23729103 95593 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 418 5 1 4 4.0 C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(-c4ccccc4F)nc3)cc2)CCN1 10.6019/CHEMBL2364262
CHEMBL2364280 95593 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 418 5 1 4 4.0 C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(-c4ccccc4F)nc3)cc2)CCN1 10.6019/CHEMBL2364262
23728578 95600 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 433 6 1 4 4.7 C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(Oc4ccccc4F)cc3)cc2)CCN1 10.6019/CHEMBL2364262
CHEMBL2364287 95600 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 433 6 1 4 4.7 C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(Oc4ccccc4F)cc3)cc2)CCN1 10.6019/CHEMBL2364262
23728582 95602 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 419 5 1 5 3.4 C[C@H]1CN(Cc2ccc(N(C)C(=O)c3cnc(-c4ccc(F)cc4)nc3)cc2)CCN1 10.6019/CHEMBL2364262
CHEMBL2364289 95602 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 419 5 1 5 3.4 C[C@H]1CN(Cc2ccc(N(C)C(=O)c3cnc(-c4ccc(F)cc4)nc3)cc2)CCN1 10.6019/CHEMBL2364262
57586303 95603 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 458 6 2 4 3.9 C[C@H]1CN(Cc2ccc(CC(=O)N3CCC(Nc4cccc(F)c4)CC3)cc2Cl)CCN1 10.6019/CHEMBL2364262
CHEMBL2364290 95603 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 458 6 2 4 3.9 C[C@H]1CN(Cc2ccc(CC(=O)N3CCC(Nc4cccc(F)c4)CC3)cc2Cl)CCN1 10.6019/CHEMBL2364262
11902 8269 8 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells
ChEMBL 465 7 2 5 3.9 C[C@H]1CN(Cc2ccc(cc2C)N(C)C(=O)[C@H]2CC[C@@H](CC2)Oc2cc(CO)ccc2)CCN1 10.1016/j.bmcl.2022.128554
56960876 8269 8 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells
ChEMBL 465 7 2 5 3.9 C[C@H]1CN(Cc2ccc(cc2C)N(C)C(=O)[C@H]2CC[C@@H](CC2)Oc2cc(CO)ccc2)CCN1 10.1016/j.bmcl.2022.128554
CHEMBL5201797 8269 8 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells
ChEMBL 465 7 2 5 3.9 C[C@H]1CN(Cc2ccc(cc2C)N(C)C(=O)[C@H]2CC[C@@H](CC2)Oc2cc(CO)ccc2)CCN1 10.1016/j.bmcl.2022.128554
89723482 198882 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells
ChEMBL 479 7 2 5 4.2 Cc1cc(N(C)C(=O)[C@H]2CC[C@H](Oc3cc(CO)ccc3C)CC2)ccc1CN1CCN[C@@H](C)C1 10.1016/j.bmcl.2022.128554
CHEMBL5203126 198882 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells
ChEMBL 479 7 2 5 4.2 Cc1cc(N(C)C(=O)[C@H]2CC[C@H](Oc3cc(CO)ccc3C)CC2)ccc1CN1CCN[C@@H](C)C1 10.1016/j.bmcl.2022.128554
44542816 204848 0 None - 1 Rabbit 7.3 pEC50 = 7.3 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 879 14 6 16 2.1 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NCCOC)[C@H](C)[C@@H](O)[C@]1(C)O 10.1021/jm901107f
CHEMBL574205 204848 0 None - 1 Rabbit 7.3 pEC50 = 7.3 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 879 14 6 16 2.1 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NCCOC)[C@H](C)[C@@H](O)[C@]1(C)O 10.1021/jm901107f
1048 8366 76 None 2 4 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1021/jm801332q
12560 8366 76 None 2 4 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1021/jm801332q
1456 8366 76 None 2 4 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1021/jm801332q
CHEMBL532 8366 76 None 2 4 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1021/jm801332q
DB00199 8366 76 None 2 4 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1021/jm801332q
15984238 196348 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay
ChEMBL 452 7 2 4 4.0 C[C@H]1CN(Cc2ccc(CCC(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1 10.1021/jm801332q
CHEMBL514475 196348 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay
ChEMBL 452 7 2 4 4.0 C[C@H]1CN(Cc2ccc(CCC(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1 10.1021/jm801332q
1048 8366 76 None 2 4 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1016/j.bmcl.2008.10.072
12560 8366 76 None 2 4 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1016/j.bmcl.2008.10.072
1456 8366 76 None 2 4 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1016/j.bmcl.2008.10.072
CHEMBL532 8366 76 None 2 4 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1016/j.bmcl.2008.10.072
DB00199 8366 76 None 2 4 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1016/j.bmcl.2008.10.072
46882393 12612 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 511 9 2 5 5.5 CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2ccc(NC(C)=O)s2)CC3)cc1 10.1016/j.bmcl.2009.09.027
CHEMBL1079170 12612 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 511 9 2 5 5.5 CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2ccc(NC(C)=O)s2)CC3)cc1 10.1016/j.bmcl.2009.09.027
44571939 187395 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay
ChEMBL 540 10 2 4 5.9 COc1cccc(CCN(Cc2ccccc2-c2ccc(CN3CCNCC3)cc2)C(=O)NC2CCCCC2)c1 10.1016/j.bmcl.2008.10.071
CHEMBL475467 187395 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay
ChEMBL 540 10 2 4 5.9 COc1cccc(CCN(Cc2ccccc2-c2ccc(CN3CCNCC3)cc2)C(=O)NC2CCCCC2)c1 10.1016/j.bmcl.2008.10.071
44570409 185193 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 459 7 1 3 4.9 C[C@H]1CN(Cc2ccc(-c3ccccc3CN(C)C(=O)Cc3ccc(F)cc3)cc2)C[C@@H](C)N1 10.1016/j.bmcl.2008.10.072
CHEMBL465940 185193 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 459 7 1 3 4.9 C[C@H]1CN(Cc2ccc(-c3ccccc3CN(C)C(=O)Cc3ccc(F)cc3)cc2)C[C@@H](C)N1 10.1016/j.bmcl.2008.10.072
44570492 190728 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 516 6 2 4 5.9 C[C@H]1CN(Cc2ccc(-c3ccccc3C(=O)N3CCC(Nc4ccc(Cl)cc4)CC3)cc2)C[C@@H](C)N1 10.1016/j.bmcl.2008.10.072
CHEMBL481575 190728 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 516 6 2 4 5.9 C[C@H]1CN(Cc2ccc(-c3ccccc3C(=O)N3CCC(Nc4ccc(Cl)cc4)CC3)cc2)C[C@@H](C)N1 10.1016/j.bmcl.2008.10.072
16752689 195147 0 None 5 3 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 568 10 2 4 6.6 COc1cccc(CCN(Cc2ccccc2-c2ccc(CN3C[C@H](C)N[C@H](C)C3)cc2)C(=O)NC2CCCCC2)c1 10.1016/j.bmcl.2008.10.072
CHEMBL501315 195147 0 None 5 3 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 568 10 2 4 6.6 COc1cccc(CCN(Cc2ccccc2-c2ccc(CN3C[C@H](C)N[C@H](C)C3)cc2)C(=O)NC2CCCCC2)c1 10.1016/j.bmcl.2008.10.072
16041483 197700 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 501 6 2 5 4.8 C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccccc4F)CC3)cc2)C[C@@H](C)N1 10.1016/j.bmcl.2008.10.072
CHEMBL518540 197700 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 501 6 2 5 4.8 C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccccc4F)CC3)cc2)C[C@@H](C)N1 10.1016/j.bmcl.2008.10.072
46882671 12406 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 387 4 1 6 1.6 O=S(=O)(Cc1ccc2c(c1)CCNCC2)c1ccc(N2CCOCC2)nc1 10.1016/j.bmcl.2009.09.027
CHEMBL1077735 12406 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 387 4 1 6 1.6 O=S(=O)(Cc1ccc2c(c1)CCNCC2)c1ccc(N2CCOCC2)nc1 10.1016/j.bmcl.2009.09.027
46882756 12537 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 412 5 1 5 3.7 O=S(=O)(Cc1ccc2c(c1)CCNCC2)c1ccc(Oc2ccc(F)cc2)nc1 10.1016/j.bmcl.2009.09.027
CHEMBL1078555 12537 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 412 5 1 5 3.7 O=S(=O)(Cc1ccc2c(c1)CCNCC2)c1ccc(Oc2ccc(F)cc2)nc1 10.1016/j.bmcl.2009.09.027
46882349 12577 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 505 9 2 4 5.4 CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cccc(NC(C)=O)c2)CC3)cc1 10.1016/j.bmcl.2009.09.027
CHEMBL1078881 12577 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 505 9 2 4 5.4 CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cccc(NC(C)=O)c2)CC3)cc1 10.1016/j.bmcl.2009.09.027
44571989 186996 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assay
ChEMBL 478 10 2 4 4.6 COCCCN(Cc1ccccc1-c1ccc(CN2CCNCC2)cc1)C(=O)NC1CCCCC1 10.1016/j.bmcl.2008.10.071
CHEMBL474978 186996 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assay
ChEMBL 478 10 2 4 4.6 COCCCN(Cc1ccccc1-c1ccc(CN2CCNCC2)cc1)C(=O)NC1CCCCC1 10.1016/j.bmcl.2008.10.071
44571373 186692 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay
ChEMBL 526 9 2 4 5.9 COc1cccc(CCN(Cc2ccccc2-c2ccc(N3CCNCC3)cc2)C(=O)NC2CCCCC2)c1 10.1016/j.bmcl.2008.10.071
CHEMBL474606 186692 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay
ChEMBL 526 9 2 4 5.9 COc1cccc(CCN(Cc2ccccc2-c2ccc(N3CCNCC3)cc2)C(=O)NC2CCCCC2)c1 10.1016/j.bmcl.2008.10.071
44571940 187710 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assay
ChEMBL 415 9 2 4 4.1 COc1cccc(CCNCc2ccccc2-c2ccc(CN3CCNCC3)cc2)c1 10.1016/j.bmcl.2008.10.071
CHEMBL475808 187710 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assay
ChEMBL 415 9 2 4 4.1 COc1cccc(CCNCc2ccccc2-c2ccc(CN3CCNCC3)cc2)c1 10.1016/j.bmcl.2008.10.071
11993730 185186 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells
ChEMBL 500 6 1 4 5.2 C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Cc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1 10.1016/j.bmcl.2022.128554
CHEMBL465925 185186 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells
ChEMBL 500 6 1 4 5.2 C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Cc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1 10.1016/j.bmcl.2022.128554
44542367 204875 0 None - 1 Rabbit 6.3 pEC50 = 6.3 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 847 11 6 15 2.3 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C3CCC3)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NC)[C@H](C)[C@@H](O)[C@]1(C)O 10.1021/jm901107f
CHEMBL574429 204875 0 None - 1 Rabbit 6.3 pEC50 = 6.3 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 847 11 6 15 2.3 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C3CCC3)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NC)[C@H](C)[C@@H](O)[C@]1(C)O 10.1021/jm901107f
44542368 205700 0 None - 1 Rabbit 7.3 pEC50 = 7.3 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 821 11 6 15 1.9 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(N)=O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2011.04.078
44542368 205700 0 None - 1 Rabbit 7.3 pEC50 = 7.3 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 821 11 6 15 1.9 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(N)=O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1021/jm901107f
CHEMBL584550 205700 0 None - 1 Rabbit 7.3 pEC50 = 7.3 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 821 11 6 15 1.9 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(N)=O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2011.04.078
CHEMBL584550 205700 0 None - 1 Rabbit 7.3 pEC50 = 7.3 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 821 11 6 15 1.9 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(N)=O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1021/jm901107f
56960873 198495 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells
ChEMBL 439 6 1 4 4.2 C[C@H]1CN(Cc2ccc(N(C)C(=O)[C@H]3CC[C@H](Oc4ccc(F)cc4)CC3)cc2)CCN1 10.1016/j.bmcl.2022.128554
CHEMBL5197045 198495 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells
ChEMBL 439 6 1 4 4.2 C[C@H]1CN(Cc2ccc(N(C)C(=O)[C@H]3CC[C@H](Oc4ccc(F)cc4)CC3)cc2)CCN1 10.1016/j.bmcl.2022.128554
11398860 182824 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
In vitro effective concentration towards human motilin receptorIn vitro effective concentration towards human motilin receptor
ChEMBL 560 8 3 10 0.4 NC(=O)[C@H](CCc1ccccc1)NC(=O)C1C=CC2(CCNCC2)n2c(=O)n(Cc3ccc4c(c3)OCO4)c(=O)n21 10.1021/jm0304865
CHEMBL45905 182824 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
In vitro effective concentration towards human motilin receptorIn vitro effective concentration towards human motilin receptor
ChEMBL 560 8 3 10 0.4 NC(=O)[C@H](CCc1ccccc1)NC(=O)C1C=CC2(CCNCC2)n2c(=O)n(Cc3ccc4c(c3)OCO4)c(=O)n21 10.1021/jm0304865
52947633 23997 0 None - 1 Rabbit 5.2 pEC50 = 5.2 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction
ChEMBL 777 8 6 15 1.3 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C3COC3)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2010.08.030
CHEMBL1256540 23997 0 None - 1 Rabbit 5.2 pEC50 = 5.2 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction
ChEMBL 777 8 6 15 1.3 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C3COC3)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2010.08.030
45483679 204697 0 None - 1 Rabbit 7.2 pEC50 = 7.2 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 835 11 6 15 2.1 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NC)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2011.04.078
45483679 204697 0 None - 1 Rabbit 7.2 pEC50 = 7.2 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 835 11 6 15 2.1 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NC)[C@H](C)[C@@H](O)[C@]1(C)O 10.1021/jm901107f
CHEMBL572996 204697 0 None - 1 Rabbit 7.2 pEC50 = 7.2 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 835 11 6 15 2.1 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NC)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2011.04.078
CHEMBL572996 204697 0 None - 1 Rabbit 7.2 pEC50 = 7.2 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 835 11 6 15 2.1 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NC)[C@H](C)[C@@H](O)[C@]1(C)O 10.1021/jm901107f
54584601 68984 0 None - 1 Rabbit 7.2 pEC50 = 7.2 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 748 8 5 13 3.4 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2011.04.078
CHEMBL1778045 68984 0 None - 1 Rabbit 7.2 pEC50 = 7.2 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 748 8 5 13 3.4 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2011.04.078
45102708 12542 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 468 6 2 7 2.0 O=S(=O)(Nc1ccc2c(c1)CCN(Cc1cc[nH]n1)CC2)c1ccc(N2CCOCC2)nc1 10.1016/j.bmcl.2009.09.027
CHEMBL1078595 12542 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 468 6 2 7 2.0 O=S(=O)(Nc1ccc2c(c1)CCN(Cc1cc[nH]n1)CC2)c1ccc(N2CCOCC2)nc1 10.1016/j.bmcl.2009.09.027
16040940 184229 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 501 6 2 5 4.8 C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4cccc(F)c4)CC3)cc2)C[C@@H](C)N1 10.1016/j.bmcl.2008.10.072
CHEMBL463881 184229 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 501 6 2 5 4.8 C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4cccc(F)c4)CC3)cc2)C[C@@H](C)N1 10.1016/j.bmcl.2008.10.072
15984999 95582 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 474 6 2 4 4.1 C[C@H]1CN(Cc2ccc(CC(=O)N3CCC(Nc4cccc(C(F)(F)F)c4)CC3)cc2)CCN1 10.6019/CHEMBL2364262
CHEMBL2364269 95582 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 474 6 2 4 4.1 C[C@H]1CN(Cc2ccc(CC(=O)N3CCC(Nc4cccc(C(F)(F)F)c4)CC3)cc2)CCN1 10.6019/CHEMBL2364262
23728692 95609 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 436 5 1 4 4.1 C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(-c4cccc(F)c4)nc3)c(F)c2)CCN1 10.6019/CHEMBL2364262
CHEMBL2364296 95609 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 436 5 1 4 4.1 C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(-c4cccc(F)c4)nc3)c(F)c2)CCN1 10.6019/CHEMBL2364262
16749781 95641 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 464 6 1 7 3.6 C[C@H]1CN(Cc2ccn(-c3cccnc3N3CCC(Oc4ccccc4F)CC3)n2)C[C@@H](C)N1 10.6019/CHEMBL2364262
CHEMBL2364327 95641 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 464 6 1 7 3.6 C[C@H]1CN(Cc2ccn(-c3cccnc3N3CCC(Oc4ccccc4F)CC3)n2)C[C@@H](C)N1 10.6019/CHEMBL2364262
54582661 68986 0 None - 1 Rabbit 7.2 pEC50 = 7.2 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 749 9 6 14 2.0 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCO)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2011.04.078
CHEMBL1778047 68986 0 None - 1 Rabbit 7.2 pEC50 = 7.2 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 749 9 6 14 2.0 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCO)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2011.04.078
15984240 186301 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay
ChEMBL 438 7 2 4 3.7 C[C@H]1CN(Cc2ccc(CCC(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)CCN1 10.1021/jm801332q
CHEMBL474129 186301 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay
ChEMBL 438 7 2 4 3.7 C[C@H]1CN(Cc2ccc(CCC(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)CCN1 10.1021/jm801332q
46882796 12522 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 385 4 1 5 2.7 O=S(=O)(Cc1ccc2c(c1)CCNCC2)c1ccc(N2CCCCC2)nc1 10.1016/j.bmcl.2009.09.027
CHEMBL1078463 12522 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 385 4 1 5 2.7 O=S(=O)(Cc1ccc2c(c1)CCNCC2)c1ccc(N2CCCCC2)nc1 10.1016/j.bmcl.2009.09.027
46882396 12616 0 None -3 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 452 8 2 4 4.5 CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cnc(C)[nH]2)CC3)cc1 10.1016/j.bmcl.2009.09.027
CHEMBL1079187 12616 0 None -3 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 452 8 2 4 4.5 CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cnc(C)[nH]2)CC3)cc1 10.1016/j.bmcl.2009.09.027
44570528 190385 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 513 6 1 4 5.4 C[C@H]1CN(Cc2ccc(-c3ccccc3C(=O)N3CCC(C(=O)c4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1 10.1016/j.bmcl.2008.10.072
CHEMBL480210 190385 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 513 6 1 4 5.4 C[C@H]1CN(Cc2ccc(-c3ccccc3C(=O)N3CCC(C(=O)c4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1 10.1016/j.bmcl.2008.10.072
44570490 197426 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 501 6 1 4 5.4 C[C@H]1CN(Cc2ccc(-c3ccccc3C(=O)N3CCC(Oc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1 10.1016/j.bmcl.2008.10.072
CHEMBL518142 197426 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 501 6 1 4 5.4 C[C@H]1CN(Cc2ccc(-c3ccccc3C(=O)N3CCC(Oc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1 10.1016/j.bmcl.2008.10.072
23728734 95618 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 445 6 1 5 3.2 C[C@H]1CN(Cc2ccc(N(C)C(=O)C3CCN(Cc4ccc(C#N)cc4)CC3)cc2)CCN1 10.6019/CHEMBL2364262
CHEMBL2364305 95618 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 445 6 1 5 3.2 C[C@H]1CN(Cc2ccc(N(C)C(=O)C3CCN(Cc4ccc(C#N)cc4)CC3)cc2)CCN1 10.6019/CHEMBL2364262
1048 8366 76 None 2 4 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1016/j.bmcl.2008.10.072
12560 8366 76 None 2 4 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1016/j.bmcl.2008.10.072
1456 8366 76 None 2 4 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1016/j.bmcl.2008.10.072
CHEMBL532 8366 76 None 2 4 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1016/j.bmcl.2008.10.072
DB00199 8366 76 None 2 4 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1016/j.bmcl.2008.10.072
44569919 185583 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 508 6 2 6 4.5 C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(C#N)cc4)CC3)cc2)C[C@@H](C)N1 10.1016/j.bmcl.2008.10.072
CHEMBL469097 185583 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 508 6 2 6 4.5 C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(C#N)cc4)CC3)cc2)C[C@@H](C)N1 10.1016/j.bmcl.2008.10.072
44572029 186185 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assay
ChEMBL 511 11 1 5 4.1 COCCCN(Cc1ccccc1-c1ccc(CN2CCNCC2)cc1)S(=O)(=O)c1ccc(F)cc1 10.1016/j.bmcl.2008.10.071
CHEMBL474008 186185 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assay
ChEMBL 511 11 1 5 4.1 COCCCN(Cc1ccccc1-c1ccc(CN2CCNCC2)cc1)S(=O)(=O)c1ccc(F)cc1 10.1016/j.bmcl.2008.10.071
44571991 187724 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assay
ChEMBL 395 9 1 4 3.1 COCCCN(Cc1ccccc1-c1ccc(CN2CCNCC2)cc1)C(C)=O 10.1016/j.bmcl.2008.10.071
CHEMBL475823 187724 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assay
ChEMBL 395 9 1 4 3.1 COCCCN(Cc1ccccc1-c1ccc(CN2CCNCC2)cc1)C(C)=O 10.1016/j.bmcl.2008.10.071
44542369 205701 0 None - 1 Rabbit 6.2 pEC50 = 6.2 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 849 11 5 15 2.5 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)N(C)C)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2011.04.078
44542369 205701 0 None - 1 Rabbit 6.2 pEC50 = 6.2 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 849 11 5 15 2.5 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)N(C)C)[C@H](C)[C@@H](O)[C@]1(C)O 10.1021/jm901107f
CHEMBL584551 205701 0 None - 1 Rabbit 6.2 pEC50 = 6.2 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 849 11 5 15 2.5 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)N(C)C)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2011.04.078
CHEMBL584551 205701 0 None - 1 Rabbit 6.2 pEC50 = 6.2 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 849 11 5 15 2.5 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)N(C)C)[C@H](C)[C@@H](O)[C@]1(C)O 10.1021/jm901107f
44541928 205702 0 None - 1 Rabbit 7.2 pEC50 = 7.2 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 849 12 6 15 2.5 CCNC(=O)CO[C@H]1[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@H]1C 10.1021/jm901107f
CHEMBL584552 205702 0 None - 1 Rabbit 7.2 pEC50 = 7.2 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 849 12 6 15 2.5 CCNC(=O)CO[C@H]1[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@H]1C 10.1021/jm901107f
44542069 204698 0 None - 1 Rabbit 7.2 pEC50 = 7.2 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 899 12 6 17 2.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)Nc2cnccn2)[C@H](C)[C@@H](O)[C@]1(C)O 10.1021/jm901107f
CHEMBL572997 204698 0 None - 1 Rabbit 7.2 pEC50 = 7.2 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 899 12 6 17 2.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)Nc2cnccn2)[C@H](C)[C@@H](O)[C@]1(C)O 10.1021/jm901107f
53322109 63043 0 None -1 2 Rabbit 8.2 pEC50 = 8.2 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction
ChEMBL 697 8 2 11 5.2 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@H]1C 10.1016/j.bmcl.2010.08.030
CHEMBL1628277 63043 0 None -1 2 Rabbit 8.2 pEC50 = 8.2 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction
ChEMBL 697 8 2 11 5.2 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@H]1C 10.1016/j.bmcl.2010.08.030
53322109 63043 0 None -1 2 Rabbit 8.2 pEC50 = 8.2 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 697 8 2 11 5.2 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@H]1C 10.1016/j.bmcl.2011.04.078
53322109 63043 0 None -1 2 Rabbit 8.2 pEC50 = 8.2 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 697 8 2 11 5.2 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@H]1C 10.1021/jm901107f
CHEMBL1628277 63043 0 None -1 2 Rabbit 8.2 pEC50 = 8.2 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 697 8 2 11 5.2 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@H]1C 10.1016/j.bmcl.2011.04.078
CHEMBL1628277 63043 0 None -1 2 Rabbit 8.2 pEC50 = 8.2 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 697 8 2 11 5.2 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@H]1C 10.1021/jm901107f
44292517 108308 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
In vitro effective concentration towards human motilin receptorIn vitro effective concentration towards human motilin receptor
ChEMBL 723 13 4 11 1.7 NC(=O)[C@@H](CCc1ccccc1)NC(=O)[C@@H](CCc1ccccc1)NC(=O)C1CCC2(CCNCC2)n2c(=O)n(Cc3ccc4c(c3)OCO4)c(=O)n21 10.1021/jm0304865
CHEMBL298224 108308 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
In vitro effective concentration towards human motilin receptorIn vitro effective concentration towards human motilin receptor
ChEMBL 723 13 4 11 1.7 NC(=O)[C@@H](CCc1ccccc1)NC(=O)[C@@H](CCc1ccccc1)NC(=O)C1CCC2(CCNCC2)n2c(=O)n(Cc3ccc4c(c3)OCO4)c(=O)n21 10.1021/jm0304865
89723612 198067 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells
ChEMBL 483 7 2 5 4.0 Cc1cc(N(C)C(=O)[C@H]2CC[C@H](Oc3ccc(F)c(CO)c3)CC2)ccc1CN1CCN[C@@H](C)C1 10.1016/j.bmcl.2022.128554
CHEMBL5190786 198067 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells
ChEMBL 483 7 2 5 4.0 Cc1cc(N(C)C(=O)[C@H]2CC[C@H](Oc3ccc(F)c(CO)c3)CC2)ccc1CN1CCN[C@@H](C)C1 10.1016/j.bmcl.2022.128554
46882752 12491 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 412 4 1 4 4.1 O=S(=O)(Cc1ccc2c(c1)CCNCC2)c1ccc(-c2ccc(Cl)cc2)nc1 10.1016/j.bmcl.2009.09.027
CHEMBL1078267 12491 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 412 4 1 4 4.1 O=S(=O)(Cc1ccc2c(c1)CCNCC2)c1ccc(-c2ccc(Cl)cc2)nc1 10.1016/j.bmcl.2009.09.027
45102707 12529 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 465 6 2 6 3.9 O=S(=O)(Nc1ccc2c(c1)CCN(Cc1cc[nH]n1)CC2)c1ccc(-c2ccccn2)s1 10.1016/j.bmcl.2009.09.027
CHEMBL1078492 12529 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 465 6 2 6 3.9 O=S(=O)(Nc1ccc2c(c1)CCN(Cc1cc[nH]n1)CC2)c1ccc(-c2ccccn2)s1 10.1016/j.bmcl.2009.09.027
46882394 12614 0 None -1 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 438 8 2 4 4.2 CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cnc[nH]2)CC3)cc1 10.1016/j.bmcl.2009.09.027
CHEMBL1079185 12614 0 None -1 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 438 8 2 4 4.2 CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cnc[nH]2)CC3)cc1 10.1016/j.bmcl.2009.09.027
44570453 185153 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 455 8 1 3 5.2 CCN(CCc1ccccc1)C(=O)c1ccccc1-c1ccc(CN2C[C@H](C)N[C@H](C)C2)cc1 10.1016/j.bmcl.2008.10.072
CHEMBL465289 185153 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 455 8 1 3 5.2 CCN(CCc1ccccc1)C(=O)c1ccccc1-c1ccc(CN2C[C@H](C)N[C@H](C)C2)cc1 10.1016/j.bmcl.2008.10.072
15984995 95578 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 442 6 2 4 3.4 C[C@H]1CN(Cc2ccc(CC(=O)N3CCC(Nc4ccc(F)c(F)c4)CC3)cc2)CCN1 10.6019/CHEMBL2364262
CHEMBL2364265 95578 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 442 6 2 4 3.4 C[C@H]1CN(Cc2ccc(CC(=O)N3CCC(Nc4ccc(F)c(F)c4)CC3)cc2)CCN1 10.6019/CHEMBL2364262
23728626 95604 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 434 6 1 5 4.1 C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(Oc4ccccc4F)nc3)cc2)CCN1 10.6019/CHEMBL2364262
CHEMBL2364291 95604 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 434 6 1 5 4.1 C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(Oc4ccccc4F)nc3)cc2)CCN1 10.6019/CHEMBL2364262
23728691 95607 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 425 5 1 5 3.7 C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(-c4cccc(C#N)c4)nc3)cc2)CCN1 10.6019/CHEMBL2364262
CHEMBL2364294 95607 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 425 5 1 5 3.7 C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(-c4cccc(C#N)c4)nc3)cc2)CCN1 10.6019/CHEMBL2364262
23728730 95613 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 438 6 1 4 3.5 C[C@H]1CN(Cc2ccc(N(C)C(=O)C3CCN(Cc4ccc(F)cc4)CC3)cc2)CCN1 10.6019/CHEMBL2364262
CHEMBL2364300 95613 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 438 6 1 4 3.5 C[C@H]1CN(Cc2ccc(N(C)C(=O)C3CCN(Cc4ccc(F)cc4)CC3)cc2)CCN1 10.6019/CHEMBL2364262
23728871 95619 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 418 5 1 4 4.0 C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(-c4cccc(F)c4)cn3)cc2)CCN1 10.6019/CHEMBL2364262
CHEMBL2364306 95619 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 418 5 1 4 4.0 C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(-c4cccc(F)c4)cn3)cc2)CCN1 10.6019/CHEMBL2364262
23728838 95620 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 418 5 1 4 4.0 C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(-c4ccc(F)cc4)cn3)cc2)CCN1 10.6019/CHEMBL2364262
CHEMBL2364307 95620 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 418 5 1 4 4.0 C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(-c4ccc(F)cc4)cn3)cc2)CCN1 10.6019/CHEMBL2364262
23728841 95625 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 430 6 1 5 3.8 COc1cccc(-c2ccc(C(=O)N(C)c3ccc(CN4CCN[C@@H](C)C4)cc3)nc2)c1 10.6019/CHEMBL2364262
CHEMBL2364311 95625 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 430 6 1 5 3.8 COc1cccc(-c2ccc(C(=O)N(C)c3ccc(CN4CCN[C@@H](C)C4)cc3)nc2)c1 10.6019/CHEMBL2364262
52946409 24000 0 None - 1 Rabbit 6.2 pEC50 = 6.2 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction
ChEMBL 780 10 7 15 1.3 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCCO)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2010.08.030
CHEMBL1256544 24000 0 None - 1 Rabbit 6.2 pEC50 = 6.2 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction
ChEMBL 780 10 7 15 1.3 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCCO)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2010.08.030
52945184 24006 0 None - 1 Rabbit 5.1 pEC50 = 5.1 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction
ChEMBL 765 9 7 15 0.9 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCN)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2010.08.030
CHEMBL1256550 24006 0 None - 1 Rabbit 5.1 pEC50 = 5.1 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction
ChEMBL 765 9 7 15 0.9 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCN)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2010.08.030
52950054 23999 0 None - 1 Rabbit 5.1 pEC50 = 5.1 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction
ChEMBL 780 10 6 15 1.6 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCOC)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2010.08.030
CHEMBL1256543 23999 0 None - 1 Rabbit 5.1 pEC50 = 5.1 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction
ChEMBL 780 10 6 15 1.6 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCOC)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/j.bmcl.2010.08.030
44542817 205514 0 None - 1 Rabbit 7.1 pEC50 = 7.1 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 911 13 6 15 3.7 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O 10.1021/jm901107f
CHEMBL582873 205514 0 None - 1 Rabbit 7.1 pEC50 = 7.1 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 911 13 6 15 3.7 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O 10.1021/jm901107f
44570364 185139 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 457 8 1 4 4.6 C[C@H]1CN(Cc2ccc(-c3ccccc3CN(C)C(=O)COc3ccccc3)cc2)C[C@@H](C)N1 10.1016/j.bmcl.2008.10.072
CHEMBL465244 185139 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 457 8 1 4 4.6 C[C@H]1CN(Cc2ccc(-c3ccccc3CN(C)C(=O)COc3ccccc3)cc2)C[C@@H](C)N1 10.1016/j.bmcl.2008.10.072
44570410 185194 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 475 7 1 3 5.4 C[C@H]1CN(Cc2ccc(-c3ccccc3CN(C)C(=O)Cc3cccc(Cl)c3)cc2)C[C@@H](C)N1 10.1016/j.bmcl.2008.10.072
CHEMBL465941 185194 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 475 7 1 3 5.4 C[C@H]1CN(Cc2ccc(-c3ccccc3CN(C)C(=O)Cc3cccc(Cl)c3)cc2)C[C@@H](C)N1 10.1016/j.bmcl.2008.10.072
23728916 95633 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 425 5 1 5 3.1 C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(N4CCC(F)CC4)nc3)cc2)CCN1 10.6019/CHEMBL2364262
CHEMBL2364319 95633 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680
ChEMBL 425 5 1 5 3.1 C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(N4CCC(F)CC4)nc3)cc2)CCN1 10.6019/CHEMBL2364262
46882519 12479 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 416 5 2 4 3.5 O=S(=O)(Nc1ccc2c(c1)CCN(Cc1cc[nH]n1)CC2)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.09.027
CHEMBL1078104 12479 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 416 5 2 4 3.5 O=S(=O)(Nc1ccc2c(c1)CCN(Cc1cc[nH]n1)CC2)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.09.027
44572030 186195 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay
ChEMBL 471 11 1 4 4.4 COCCCN(Cc1ccccc1-c1ccc(CN2CCNCC2)cc1)C(=O)Cc1ccccc1 10.1016/j.bmcl.2008.10.071
CHEMBL474018 186195 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay
ChEMBL 471 11 1 4 4.4 COCCCN(Cc1ccccc1-c1ccc(CN2CCNCC2)cc1)C(=O)Cc1ccccc1 10.1016/j.bmcl.2008.10.071
44569920 196192 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 508 6 2 6 4.5 C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccccc4C#N)CC3)cc2)C[C@@H](C)N1 10.1016/j.bmcl.2008.10.072
CHEMBL513183 196192 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
ChEMBL 508 6 2 6 4.5 C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccccc4C#N)CC3)cc2)C[C@@H](C)N1 10.1016/j.bmcl.2008.10.072
46882461 13084 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 407 5 2 5 2.7 N#Cc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cc[nH]n2)CC3)cc1 10.1016/j.bmcl.2009.09.027
CHEMBL1081860 13084 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
ChEMBL 407 5 2 5 2.7 N#Cc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cc[nH]n2)CC3)cc1 10.1016/j.bmcl.2009.09.027
44542214 205546 0 None - 1 Rabbit 7.1 pEC50 = 7.1 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 863 13 6 15 2.9 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCCCC(=O)NC)[C@H](C)[C@@H](O)[C@]1(C)O 10.1021/jm901107f
CHEMBL583095 205546 0 None - 1 Rabbit 7.1 pEC50 = 7.1 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 863 13 6 15 2.9 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCCCC(=O)NC)[C@H](C)[C@@H](O)[C@]1(C)O 10.1021/jm901107f
44542666 205549 0 None - 1 Rabbit 7.1 pEC50 = 7.1 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 819 11 5 14 3.0 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NC)[C@H](C)[C@@H](O)[C@H]1C 10.1021/jm901107f
CHEMBL583098 205549 0 None - 1 Rabbit 7.1 pEC50 = 7.1 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 819 11 5 14 3.0 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NC)[C@H](C)[C@@H](O)[C@H]1C 10.1021/jm901107f
44542815 205023 0 None - 1 Rabbit 7.0 pEC50 = 7.0 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 851 12 6 16 2.1 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NOC)[C@H](C)[C@@H](O)[C@]1(C)O 10.1021/jm901107f
CHEMBL575518 205023 0 None - 1 Rabbit 7.0 pEC50 = 7.0 Functional
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
ChEMBL 851 12 6 16 2.1 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NOC)[C@H](C)[C@@H](O)[C@]1(C)O 10.1021/jm901107f
15984937 7572 31 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells
ChEMBL 424 6 2 4 3.3 C[C@@H]1NCCN(C1)Cc1ccc(cc1)CC(=O)N1CCC(CC1)Nc1cccc(c1)F 10.1016/j.bmcl.2022.128554
4035 7572 31 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells
ChEMBL 424 6 2 4 3.3 C[C@@H]1NCCN(C1)Cc1ccc(cc1)CC(=O)N1CCC(CC1)Nc1cccc(c1)F 10.1016/j.bmcl.2022.128554
CHEMBL489095 7572 31 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells
ChEMBL 424 6 2 4 3.3 C[C@@H]1NCCN(C1)Cc1ccc(cc1)CC(=O)N1CCC(CC1)Nc1cccc(c1)F 10.1016/j.bmcl.2022.128554
DB12567 7572 31 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells
ChEMBL 424 6 2 4 3.3 C[C@@H]1NCCN(C1)Cc1ccc(cc1)CC(=O)N1CCC(CC1)Nc1cccc(c1)F 10.1016/j.bmcl.2022.128554
23656869 154634 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assayAntagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assay
ChEMBL 631 5 4 6 3.1 CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(C(F)(F)F)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CN2CCCC2)NC1=O 10.1016/j.bmcl.2007.05.043
CHEMBL393315 154634 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assayAntagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assay
ChEMBL 631 5 4 6 3.1 CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(C(F)(F)F)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CN2CCCC2)NC1=O 10.1016/j.bmcl.2007.05.043
23557214 147861 0 None 6 2 Rabbit 7.7 pIC50 = 7.7 Functional
Activity at rabbit duodenum motilin receptor by tissue contractility assayActivity at rabbit duodenum motilin receptor by tissue contractility assay
ChEMBL 721 11 0 4 8.9 O=C(c1ccc(F)cc1)N(CC1CCCC(N(Cc2cccc(Cl)c2)C(=O)C(Cl)(Cl)Cl)C1)c1cccc(OCCN2CCCCC2)c1 10.1016/j.bmcl.2006.04.017
CHEMBL382613 147861 0 None 6 2 Rabbit 7.7 pIC50 = 7.7 Functional
Activity at rabbit duodenum motilin receptor by tissue contractility assayActivity at rabbit duodenum motilin receptor by tissue contractility assay
ChEMBL 721 11 0 4 8.9 O=C(c1ccc(F)cc1)N(CC1CCCC(N(Cc2cccc(Cl)c2)C(=O)C(Cl)(Cl)Cl)C1)c1cccc(OCCN2CCCCC2)c1 10.1016/j.bmcl.2006.04.017
23557214 147861 0 None -6 2 Human 6.6 pIC50 = 6.6 Functional
Activity at human motilin receptor transfected in HEK293 cells assessed as inhibition of motilin-induced intracellular calcium mobilizationActivity at human motilin receptor transfected in HEK293 cells assessed as inhibition of motilin-induced intracellular calcium mobilization
ChEMBL 721 11 0 4 8.9 O=C(c1ccc(F)cc1)N(CC1CCCC(N(Cc2cccc(Cl)c2)C(=O)C(Cl)(Cl)Cl)C1)c1cccc(OCCN2CCCCC2)c1 10.1016/j.bmcl.2006.04.017
CHEMBL382613 147861 0 None -6 2 Human 6.6 pIC50 = 6.6 Functional
Activity at human motilin receptor transfected in HEK293 cells assessed as inhibition of motilin-induced intracellular calcium mobilizationActivity at human motilin receptor transfected in HEK293 cells assessed as inhibition of motilin-induced intracellular calcium mobilization
ChEMBL 721 11 0 4 8.9 O=C(c1ccc(F)cc1)N(CC1CCCC(N(Cc2cccc(Cl)c2)C(=O)C(Cl)(Cl)Cl)C1)c1cccc(OCCN2CCCCC2)c1 10.1016/j.bmcl.2006.04.017
11341873 148282 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Activity at human MOTR expressed in CHO cells assessed as inhibition of motilin-induced calcium releaseActivity at human MOTR expressed in CHO cells assessed as inhibition of motilin-induced calcium release
ChEMBL 552 6 4 6 2.8 CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(OC)cc2)NCCOc2ccccc2CCCNC1=O 10.1021/jm0606600
CHEMBL384501 148282 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Activity at human MOTR expressed in CHO cells assessed as inhibition of motilin-induced calcium releaseActivity at human MOTR expressed in CHO cells assessed as inhibition of motilin-induced calcium release
ChEMBL 552 6 4 6 2.8 CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(OC)cc2)NCCOc2ccccc2CCCNC1=O 10.1021/jm0606600
23557218 146334 0 None 38 2 Rabbit 7.6 pIC50 = 7.6 Functional
Activity at rabbit duodenum motilin receptor by tissue contractility assayActivity at rabbit duodenum motilin receptor by tissue contractility assay
ChEMBL 613 11 0 4 7.6 CC(C)(C)C(=O)N(Cc1ccccc1)C1CCCC(CN(C(=O)c2ccc(F)cc2)c2cccc(OCCN3CCCC3)c2)C1 10.1016/j.bmcl.2006.04.017
CHEMBL379665 146334 0 None 38 2 Rabbit 7.6 pIC50 = 7.6 Functional
Activity at rabbit duodenum motilin receptor by tissue contractility assayActivity at rabbit duodenum motilin receptor by tissue contractility assay
ChEMBL 613 11 0 4 7.6 CC(C)(C)C(=O)N(Cc1ccccc1)C1CCCC(CN(C(=O)c2ccc(F)cc2)c2cccc(OCCN3CCCC3)c2)C1 10.1016/j.bmcl.2006.04.017
12016400 175739 0 None -11 2 Human 5.6 pIC50 = 5.6 Functional
Activity at human motilin receptor transfected in HEK293 cells assessed as inhibition of motilin-induced intracellular calcium mobilizationActivity at human motilin receptor transfected in HEK293 cells assessed as inhibition of motilin-induced intracellular calcium mobilization
ChEMBL 613 11 0 4 7.6 CC(C)(C)C(=O)N(Cc1ccccc1)[C@H]1CCC[C@@H](CN(C(=O)c2ccc(F)cc2)c2cccc(OCCN3CCCC3)c2)C1 10.1016/j.bmcl.2006.04.017
CHEMBL438962 175739 0 None -11 2 Human 5.6 pIC50 = 5.6 Functional
Activity at human motilin receptor transfected in HEK293 cells assessed as inhibition of motilin-induced intracellular calcium mobilizationActivity at human motilin receptor transfected in HEK293 cells assessed as inhibition of motilin-induced intracellular calcium mobilization
ChEMBL 613 11 0 4 7.6 CC(C)(C)C(=O)N(Cc1ccccc1)[C@H]1CCC[C@@H](CN(C(=O)c2ccc(F)cc2)c2cccc(OCCN3CCCC3)c2)C1 10.1016/j.bmcl.2006.04.017
44412878 147860 0 None -5 2 Human 6.6 pIC50 = 6.6 Functional
Activity at human motilin receptor transfected in HEK293 cells assessed as inhibition of motilin-induced intracellular calcium mobilizationActivity at human motilin receptor transfected in HEK293 cells assessed as inhibition of motilin-induced intracellular calcium mobilization
ChEMBL 707 11 0 4 8.6 O=C(c1ccc(F)cc1)N(CC1CCCC(N(Cc2cccc(Cl)c2)C(=O)C(Cl)(Cl)Cl)C1)c1cccc(OCCN2CCCC2)c1 10.1016/j.bmcl.2006.04.017
CHEMBL382612 147860 0 None -5 2 Human 6.6 pIC50 = 6.6 Functional
Activity at human motilin receptor transfected in HEK293 cells assessed as inhibition of motilin-induced intracellular calcium mobilizationActivity at human motilin receptor transfected in HEK293 cells assessed as inhibition of motilin-induced intracellular calcium mobilization
ChEMBL 707 11 0 4 8.6 O=C(c1ccc(F)cc1)N(CC1CCCC(N(Cc2cccc(Cl)c2)C(=O)C(Cl)(Cl)Cl)C1)c1cccc(OCCN2CCCC2)c1 10.1016/j.bmcl.2006.04.017
44412861 84649 0 None - 1 Rabbit 7.6 pIC50 = 7.6 Functional
Activity at rabbit duodenum motilin receptor by tissue contractility assayActivity at rabbit duodenum motilin receptor by tissue contractility assay
ChEMBL 673 11 0 4 7.9 O=C(c1ccc(F)cc1)N(CC1CCCC(N(Cc2ccccc2)C(=O)C(Cl)(Cl)Cl)C1)c1cccc(OCCN2CCCC2)c1 10.1016/j.bmcl.2006.04.017
CHEMBL209333 84649 0 None - 1 Rabbit 7.6 pIC50 = 7.6 Functional
Activity at rabbit duodenum motilin receptor by tissue contractility assayActivity at rabbit duodenum motilin receptor by tissue contractility assay
ChEMBL 673 11 0 4 7.9 O=C(c1ccc(F)cc1)N(CC1CCCC(N(Cc2ccccc2)C(=O)C(Cl)(Cl)Cl)C1)c1cccc(OCCN2CCCC2)c1 10.1016/j.bmcl.2006.04.017
44432977 158459 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assayAntagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assay
ChEMBL 619 5 7 6 1.5 CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(C(F)(F)F)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CNC(=N)N)NC1=O 10.1016/j.bmcl.2007.05.043
CHEMBL396413 158459 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assayAntagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assay
ChEMBL 619 5 7 6 1.5 CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(C(F)(F)F)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CNC(=N)N)NC1=O 10.1016/j.bmcl.2007.05.043
44432975 94515 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assayAntagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assay
ChEMBL 591 5 5 6 2.2 CNC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2cccc(C(F)(F)F)c2)NCCOc2ccccc2CCCNC1=O 10.1016/j.bmcl.2007.05.043
CHEMBL233711 94515 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assayAntagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assay
ChEMBL 591 5 5 6 2.2 CNC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2cccc(C(F)(F)F)c2)NCCOc2ccccc2CCCNC1=O 10.1016/j.bmcl.2007.05.043
44432974 94339 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assayAntagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assay
ChEMBL 557 5 5 6 1.8 CNC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NCCOc2ccccc2CCCNC1=O 10.1016/j.bmcl.2007.05.043
CHEMBL233560 94339 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assayAntagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assay
ChEMBL 557 5 5 6 1.8 CNC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NCCOc2ccccc2CCCNC1=O 10.1016/j.bmcl.2007.05.043
9895192 84630 0 None -38 2 Human 6.5 pIC50 = 6.5 Functional
Activity at human motilin receptor transfected in HEK293 cells assessed as inhibition of motilin-induced intracellular calcium mobilizationActivity at human motilin receptor transfected in HEK293 cells assessed as inhibition of motilin-induced intracellular calcium mobilization
ChEMBL 613 11 0 4 7.6 CC(C)(C)C(=O)N(Cc1ccccc1)[C@@H]1CCC[C@H](CN(C(=O)c2ccc(F)cc2)c2cccc(OCCN3CCCC3)c2)C1 10.1016/j.bmcl.2006.04.017
CHEMBL209301 84630 0 None -38 2 Human 6.5 pIC50 = 6.5 Functional
Activity at human motilin receptor transfected in HEK293 cells assessed as inhibition of motilin-induced intracellular calcium mobilizationActivity at human motilin receptor transfected in HEK293 cells assessed as inhibition of motilin-induced intracellular calcium mobilization
ChEMBL 613 11 0 4 7.6 CC(C)(C)C(=O)N(Cc1ccccc1)[C@@H]1CCC[C@H](CN(C(=O)c2ccc(F)cc2)c2cccc(OCCN3CCCC3)c2)C1 10.1016/j.bmcl.2006.04.017
44412878 147860 0 None 5 2 Rabbit 7.4 pIC50 = 7.4 Functional
Activity at rabbit duodenum motilin receptor by tissue contractility assayActivity at rabbit duodenum motilin receptor by tissue contractility assay
ChEMBL 707 11 0 4 8.6 O=C(c1ccc(F)cc1)N(CC1CCCC(N(Cc2cccc(Cl)c2)C(=O)C(Cl)(Cl)Cl)C1)c1cccc(OCCN2CCCC2)c1 10.1016/j.bmcl.2006.04.017
CHEMBL382612 147860 0 None 5 2 Rabbit 7.4 pIC50 = 7.4 Functional
Activity at rabbit duodenum motilin receptor by tissue contractility assayActivity at rabbit duodenum motilin receptor by tissue contractility assay
ChEMBL 707 11 0 4 8.6 O=C(c1ccc(F)cc1)N(CC1CCCC(N(Cc2cccc(Cl)c2)C(=O)C(Cl)(Cl)Cl)C1)c1cccc(OCCN2CCCC2)c1 10.1016/j.bmcl.2006.04.017
44412894 145688 0 None -1 2 Human 7.3 pIC50 = 7.3 Functional
Activity at human motilin receptor transfected in HEK293 cells assessed as inhibition of motilin-induced intracellular calcium mobilizationActivity at human motilin receptor transfected in HEK293 cells assessed as inhibition of motilin-induced intracellular calcium mobilization
ChEMBL 718 12 0 6 7.8 O=C(c1ccc(F)cc1)N(CC1CCCC(N(Cc2cccc([N+](=O)[O-])c2)C(=O)C(Cl)(Cl)Cl)C1)c1cccc(OCCN2CCCC2)c1 10.1016/j.bmcl.2006.04.017
CHEMBL378317 145688 0 None -1 2 Human 7.3 pIC50 = 7.3 Functional
Activity at human motilin receptor transfected in HEK293 cells assessed as inhibition of motilin-induced intracellular calcium mobilizationActivity at human motilin receptor transfected in HEK293 cells assessed as inhibition of motilin-induced intracellular calcium mobilization
ChEMBL 718 12 0 6 7.8 O=C(c1ccc(F)cc1)N(CC1CCCC(N(Cc2cccc([N+](=O)[O-])c2)C(=O)C(Cl)(Cl)Cl)C1)c1cccc(OCCN2CCCC2)c1 10.1016/j.bmcl.2006.04.017
25114977 153787 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assayAntagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assay
ChEMBL 594 5 4 7 2.5 CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(Cl)c2)NCCOc2ccccc2CCCNC(=O)[C@H](Cn2cccn2)NC1=O 10.1016/j.bmcl.2007.05.043
CHEMBL392657 153787 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assayAntagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assay
ChEMBL 594 5 4 7 2.5 CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(Cl)c2)NCCOc2ccccc2CCCNC(=O)[C@H](Cn2cccn2)NC1=O 10.1016/j.bmcl.2007.05.043
12016400 175739 0 None 11 2 Rabbit 6.2 pIC50 = 6.2 Functional
Activity at rabbit duodenum motilin receptor by tissue contractility assayActivity at rabbit duodenum motilin receptor by tissue contractility assay
ChEMBL 613 11 0 4 7.6 CC(C)(C)C(=O)N(Cc1ccccc1)[C@H]1CCC[C@@H](CN(C(=O)c2ccc(F)cc2)c2cccc(OCCN3CCCC3)c2)C1 10.1016/j.bmcl.2006.04.017
CHEMBL438962 175739 0 None 11 2 Rabbit 6.2 pIC50 = 6.2 Functional
Activity at rabbit duodenum motilin receptor by tissue contractility assayActivity at rabbit duodenum motilin receptor by tissue contractility assay
ChEMBL 613 11 0 4 7.6 CC(C)(C)C(=O)N(Cc1ccccc1)[C@H]1CCC[C@@H](CN(C(=O)c2ccc(F)cc2)c2cccc(OCCN3CCCC3)c2)C1 10.1016/j.bmcl.2006.04.017
44412894 145688 0 None 1 2 Rabbit 7.1 pIC50 = 7.1 Functional
Activity at rabbit duodenum motilin receptor by tissue contractility assayActivity at rabbit duodenum motilin receptor by tissue contractility assay
ChEMBL 718 12 0 6 7.8 O=C(c1ccc(F)cc1)N(CC1CCCC(N(Cc2cccc([N+](=O)[O-])c2)C(=O)C(Cl)(Cl)Cl)C1)c1cccc(OCCN2CCCC2)c1 10.1016/j.bmcl.2006.04.017
CHEMBL378317 145688 0 None 1 2 Rabbit 7.1 pIC50 = 7.1 Functional
Activity at rabbit duodenum motilin receptor by tissue contractility assayActivity at rabbit duodenum motilin receptor by tissue contractility assay
ChEMBL 718 12 0 6 7.8 O=C(c1ccc(F)cc1)N(CC1CCCC(N(Cc2cccc([N+](=O)[O-])c2)C(=O)C(Cl)(Cl)Cl)C1)c1cccc(OCCN2CCCC2)c1 10.1016/j.bmcl.2006.04.017
11994554 87347 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Activity at human MOTR expressed in CHO cells assessed as inhibition of motilin-induced calcium releaseActivity at human MOTR expressed in CHO cells assessed as inhibition of motilin-induced calcium release
ChEMBL 536 5 5 6 2.5 CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC1=O 10.1021/jm0606600
CHEMBL214935 87347 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Activity at human MOTR expressed in CHO cells assessed as inhibition of motilin-induced calcium releaseActivity at human MOTR expressed in CHO cells assessed as inhibition of motilin-induced calcium release
ChEMBL 536 5 5 6 2.5 CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC1=O 10.1021/jm0606600
11994554 87347 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assayAntagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assay
ChEMBL 536 5 5 6 2.5 CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC1=O 10.1016/j.bmcl.2007.05.043
CHEMBL214935 87347 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assayAntagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assay
ChEMBL 536 5 5 6 2.5 CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC1=O 10.1016/j.bmcl.2007.05.043
9895192 84630 0 None 38 2 Rabbit 8.1 pIC50 = 8.1 Functional
Activity at rabbit duodenum motilin receptor by tissue contractility assayActivity at rabbit duodenum motilin receptor by tissue contractility assay
ChEMBL 613 11 0 4 7.6 CC(C)(C)C(=O)N(Cc1ccccc1)[C@@H]1CCC[C@H](CN(C(=O)c2ccc(F)cc2)c2cccc(OCCN3CCCC3)c2)C1 10.1016/j.bmcl.2006.04.017
CHEMBL209301 84630 0 None 38 2 Rabbit 8.1 pIC50 = 8.1 Functional
Activity at rabbit duodenum motilin receptor by tissue contractility assayActivity at rabbit duodenum motilin receptor by tissue contractility assay
ChEMBL 613 11 0 4 7.6 CC(C)(C)C(=O)N(Cc1ccccc1)[C@@H]1CCC[C@H](CN(C(=O)c2ccc(F)cc2)c2cccc(OCCN3CCCC3)c2)C1 10.1016/j.bmcl.2006.04.017
44432973 105088 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assayAntagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assay
ChEMBL 577 4 5 6 1.9 CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(C(F)(F)F)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CN)NC1=O 10.1016/j.bmcl.2007.05.043
CHEMBL274876 105088 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assayAntagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assay
ChEMBL 577 4 5 6 1.9 CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(C(F)(F)F)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CN)NC1=O 10.1016/j.bmcl.2007.05.043
44432976 161643 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assayAntagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assay
ChEMBL 571 5 4 6 2.2 CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(Cl)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CN(C)C)NC1=O 10.1016/j.bmcl.2007.05.043
CHEMBL400635 161643 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assayAntagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assay
ChEMBL 571 5 4 6 2.2 CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(Cl)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CN(C)C)NC1=O 10.1016/j.bmcl.2007.05.043
23557218 146334 0 None -38 2 Human 6.0 pIC50 = 6 Functional
Activity at human motilin receptor transfected in HEK293 cells assessed as inhibition of motilin-induced intracellular calcium mobilizationActivity at human motilin receptor transfected in HEK293 cells assessed as inhibition of motilin-induced intracellular calcium mobilization
ChEMBL 613 11 0 4 7.6 CC(C)(C)C(=O)N(Cc1ccccc1)C1CCCC(CN(C(=O)c2ccc(F)cc2)c2cccc(OCCN3CCCC3)c2)C1 10.1016/j.bmcl.2006.04.017
CHEMBL379665 146334 0 None -38 2 Human 6.0 pIC50 = 6 Functional
Activity at human motilin receptor transfected in HEK293 cells assessed as inhibition of motilin-induced intracellular calcium mobilizationActivity at human motilin receptor transfected in HEK293 cells assessed as inhibition of motilin-induced intracellular calcium mobilization
ChEMBL 613 11 0 4 7.6 CC(C)(C)C(=O)N(Cc1ccccc1)C1CCCC(CN(C(=O)c2ccc(F)cc2)c2cccc(OCCN3CCCC3)c2)C1 10.1016/j.bmcl.2006.04.017
CHEMBL496391 220862 0 None - 1 Rabbit 7.9 pKd = 7.9 Functional
Antagonist activity at MTL receptor in rabbit duodenum homogenateAntagonist activity at MTL receptor in rabbit duodenum homogenate
ChEMBL None None None CC(C)[C@@H](C(=O)N[C@@H](Cc1ccc(O)c(C(C)(C)C)c1)C(N)=O)N(C)C(=O)[C@@H](N)Cc1ccccc1 10.1016/j.bmcl.2009.05.059
CHEMBL496389 220860 0 None - 1 Rabbit 6.9 pKd = 6.9 Functional
Antagonist activity at MTL receptor in rabbit duodenum homogenateAntagonist activity at MTL receptor in rabbit duodenum homogenate
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)c(C(C)(C)C)c1)C(N)=O 10.1016/j.bmcl.2009.05.059
CHEMBL497004 220863 0 None - 1 Rabbit 7.8 pKd = 7.8 Functional
Antagonist activity at MTL receptor in rabbit duodenum homogenateAntagonist activity at MTL receptor in rabbit duodenum homogenate
ChEMBL None None None CC(C)(C)c1cc(C[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccccc2)c2ccccc2)C(N)=O)ccc1O 10.1016/j.bmcl.2009.05.059
44583348 194619 0 None - 1 Rabbit 8.6 pKd = 8.6 Functional
Antagonist activity at MTL receptor in rabbit duodenum homogenateAntagonist activity at MTL receptor in rabbit duodenum homogenate
ChEMBL 510 10 3 5 2.6 CC(C)[C@@H](C(=O)N(C)[C@@H](Cc1ccc(O)c(C(C)(C)C)c1)C(N)=O)N(C)C(=O)[C@@H](N)Cc1ccccc1 10.1016/j.bmcl.2009.05.059
CHEMBL496190 194619 0 None - 1 Rabbit 8.6 pKd = 8.6 Functional
Antagonist activity at MTL receptor in rabbit duodenum homogenateAntagonist activity at MTL receptor in rabbit duodenum homogenate
ChEMBL 510 10 3 5 2.6 CC(C)[C@@H](C(=O)N(C)[C@@H](Cc1ccc(O)c(C(C)(C)C)c1)C(N)=O)N(C)C(=O)[C@@H](N)Cc1ccccc1 10.1016/j.bmcl.2009.05.059
9956253 194620 0 None - 1 Rabbit 8.4 pKd = 8.4 Functional
Antagonist activity at MTL receptor in rabbit duodenum homogenateAntagonist activity at MTL receptor in rabbit duodenum homogenate
ChEMBL 467 9 3 4 3.8 CC(C)[C@@H](C(=O)N[C@H](C)Cc1ccc(O)c(C(C)(C)C)c1)N(C)C(=O)[C@@H](N)Cc1ccccc1 10.1016/j.bmcl.2009.05.059
CHEMBL496191 194620 0 None - 1 Rabbit 8.4 pKd = 8.4 Functional
Antagonist activity at MTL receptor in rabbit duodenum homogenateAntagonist activity at MTL receptor in rabbit duodenum homogenate
ChEMBL 467 9 3 4 3.8 CC(C)[C@@H](C(=O)N[C@H](C)Cc1ccc(O)c(C(C)(C)C)c1)N(C)C(=O)[C@@H](N)Cc1ccccc1 10.1016/j.bmcl.2009.05.059
44583286 200229 0 None - 1 Rabbit 7.4 pKd = 7.4 Functional
Antagonist activity at MTL receptor in rabbit duodenum homogenateAntagonist activity at MTL receptor in rabbit duodenum homogenate
ChEMBL 564 6 5 6 2.8 CC(C)(C)c1cc(C[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H](N)Cc3ccccc3)CCCCCC(=O)CCNC2=O)ccc1O 10.1016/j.bmcl.2009.05.059
CHEMBL526496 200229 0 None - 1 Rabbit 7.4 pKd = 7.4 Functional
Antagonist activity at MTL receptor in rabbit duodenum homogenateAntagonist activity at MTL receptor in rabbit duodenum homogenate
ChEMBL 564 6 5 6 2.8 CC(C)(C)c1cc(C[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H](N)Cc3ccccc3)CCCCCC(=O)CCNC2=O)ccc1O 10.1016/j.bmcl.2009.05.059
CHEMBL496390 220861 0 None - 1 Rabbit 7.3 pKd = 7.3 Functional
Antagonist activity at MTL receptor in rabbit duodenum homogenateAntagonist activity at MTL receptor in rabbit duodenum homogenate
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)c(C(C)(C)C)c1)C(N)=O 10.1016/j.bmcl.2009.05.059
44583347 194599 0 None - 1 Rabbit 7.2 pKd = 7.2 Functional
Antagonist activity at MTL receptor in rabbit duodenum homogenateAntagonist activity at MTL receptor in rabbit duodenum homogenate
ChEMBL 496 10 4 5 2.3 CC(C)[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N(C)[C@@H](Cc1ccc(O)c(C(C)(C)C)c1)C(N)=O 10.1016/j.bmcl.2009.05.059
CHEMBL495994 194599 0 None - 1 Rabbit 7.2 pKd = 7.2 Functional
Antagonist activity at MTL receptor in rabbit duodenum homogenateAntagonist activity at MTL receptor in rabbit duodenum homogenate
ChEMBL 496 10 4 5 2.3 CC(C)[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N(C)[C@@H](Cc1ccc(O)c(C(C)(C)C)c1)C(N)=O 10.1016/j.bmcl.2009.05.059
CHEMBL502792 220937 0 None - 1 Rabbit 7.2 pKd = 7.2 Functional
Antagonist activity at MTL receptor in rabbit duodenum homogenateAntagonist activity at MTL receptor in rabbit duodenum homogenate
ChEMBL None None None CC(C)(C)c1cc(C[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)Cc2ccccc2)C(N)=O)ccc1O 10.1016/j.bmcl.2009.05.059
1466 8609 0 None - 1 Rabbit 7.4 pA2 = 7.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10081621
1466 8609 0 None - 1 Rabbit 7.4 pA2 = 7.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7752063
9850904 8609 0 None - 1 Rabbit 7.4 pA2 = 7.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10081621
9850904 8609 0 None - 1 Rabbit 7.4 pA2 = 7.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7752063
CHEMBL3143516 8609 0 None - 1 Rabbit 7.4 pA2 = 7.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10081621
CHEMBL3143516 8609 0 None - 1 Rabbit 7.4 pA2 = 7.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7752063
4036 9230 0 None - 1 Human 9.2 pA2 = 9.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 592 12 4 5 3.7 CCNC(=O)[C@@H](NC(=O)[C@@H](N(C(=O)[C@H](Cc1ccc(cc1)F)NC)C)C(C)C)Cc1ccc(c(c1)C(C)(C)C)O.Cl 18164286
73755070 9230 0 None - 1 Human 9.2 pA2 = 9.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 592 12 4 5 3.7 CCNC(=O)[C@@H](NC(=O)[C@@H](N(C(=O)[C@H](Cc1ccc(cc1)F)NC)C)C(C)C)Cc1ccc(c(c1)C(C)(C)C)O.Cl 18164286
138107041 7349 65 None 60 3 Human 8.3 pEC50 = 8.3 Functional
NoneNone
Drug Central 749 7 5 14 1.9 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](CN([C@@H]([C@H]([C@]1(C)O)O)C)C)C)(C)O None
276 7349 65 None 60 3 Human 8.3 pEC50 = 8.3 Functional
NoneNone
Drug Central 749 7 5 14 1.9 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](CN([C@@H]([C@H]([C@]1(C)O)O)C)C)C)(C)O None
447043 7349 65 None 60 3 Human 8.3 pEC50 = 8.3 Functional
NoneNone
Drug Central 749 7 5 14 1.9 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](CN([C@@H]([C@H]([C@]1(C)O)O)C)C)C)(C)O None
6510 7349 65 None 60 3 Human 8.3 pEC50 = 8.3 Functional
NoneNone
Drug Central 749 7 5 14 1.9 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](CN([C@@H]([C@H]([C@]1(C)O)O)C)C)C)(C)O None
CHEMBL529 7349 65 None 60 3 Human 8.3 pEC50 = 8.3 Functional
NoneNone
Drug Central 749 7 5 14 1.9 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](CN([C@@H]([C@H]([C@]1(C)O)O)C)C)C)(C)O None
DB00207 7349 65 None 60 3 Human 8.3 pEC50 = 8.3 Functional
NoneNone
Drug Central 749 7 5 14 1.9 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](CN([C@@H]([C@H]([C@]1(C)O)O)C)C)C)(C)O None
138107041 7349 65 None 60 3 Human 5.5 pEC50 = 5.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 749 7 5 14 1.9 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](CN([C@@H]([C@H]([C@]1(C)O)O)C)C)C)(C)O 23190027
276 7349 65 None 60 3 Human 5.5 pEC50 = 5.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 749 7 5 14 1.9 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](CN([C@@H]([C@H]([C@]1(C)O)O)C)C)C)(C)O 23190027
447043 7349 65 None 60 3 Human 5.5 pEC50 = 5.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 749 7 5 14 1.9 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](CN([C@@H]([C@H]([C@]1(C)O)O)C)C)C)(C)O 23190027
6510 7349 65 None 60 3 Human 5.5 pEC50 = 5.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 749 7 5 14 1.9 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](CN([C@@H]([C@H]([C@]1(C)O)O)C)C)C)(C)O 23190027
CHEMBL529 7349 65 None 60 3 Human 5.5 pEC50 = 5.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 749 7 5 14 1.9 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](CN([C@@H]([C@H]([C@]1(C)O)O)C)C)C)(C)O 23190027
DB00207 7349 65 None 60 3 Human 5.5 pEC50 = 5.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 749 7 5 14 1.9 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](CN([C@@H]([C@H]([C@]1(C)O)O)C)C)C)(C)O 23190027
177964 9322 2 None -3 2 Rabbit 7.7 pEC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 755 9 2 13 4.5 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@H]([C@]2(OC(=C(C)C2)[C@@H](C(=O)[C@]1(C)OC)C)C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C(C)C)C 17183187
3511 9322 2 None -3 2 Rabbit 7.7 pEC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 755 9 2 13 4.5 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@H]([C@]2(OC(=C(C)C2)[C@@H](C(=O)[C@]1(C)OC)C)C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C(C)C)C 17183187
CHEMBL1778156 9322 2 None -3 2 Rabbit 7.7 pEC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 755 9 2 13 4.5 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@H]([C@]2(OC(=C(C)C2)[C@@H](C(=O)[C@]1(C)OC)C)C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C(C)C)C 17183187
15984937 7572 31 None - 1 Human 7.9 pEC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 424 6 2 4 3.3 C[C@@H]1NCCN(C1)Cc1ccc(cc1)CC(=O)N1CCC(CC1)Nc1cccc(c1)F 19374732
15984937 7572 31 None - 1 Human 7.9 pEC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 424 6 2 4 3.3 C[C@@H]1NCCN(C1)Cc1ccc(cc1)CC(=O)N1CCC(CC1)Nc1cccc(c1)F 25341626
4035 7572 31 None - 1 Human 7.9 pEC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 424 6 2 4 3.3 C[C@@H]1NCCN(C1)Cc1ccc(cc1)CC(=O)N1CCC(CC1)Nc1cccc(c1)F 19374732
4035 7572 31 None - 1 Human 7.9 pEC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 424 6 2 4 3.3 C[C@@H]1NCCN(C1)Cc1ccc(cc1)CC(=O)N1CCC(CC1)Nc1cccc(c1)F 25341626
CHEMBL489095 7572 31 None - 1 Human 7.9 pEC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 424 6 2 4 3.3 C[C@@H]1NCCN(C1)Cc1ccc(cc1)CC(=O)N1CCC(CC1)Nc1cccc(c1)F 19374732
CHEMBL489095 7572 31 None - 1 Human 7.9 pEC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 424 6 2 4 3.3 C[C@@H]1NCCN(C1)Cc1ccc(cc1)CC(=O)N1CCC(CC1)Nc1cccc(c1)F 25341626
DB12567 7572 31 None - 1 Human 7.9 pEC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 424 6 2 4 3.3 C[C@@H]1NCCN(C1)Cc1ccc(cc1)CC(=O)N1CCC(CC1)Nc1cccc(c1)F 19374732
DB12567 7572 31 None - 1 Human 7.9 pEC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 424 6 2 4 3.3 C[C@@H]1NCCN(C1)Cc1ccc(cc1)CC(=O)N1CCC(CC1)Nc1cccc(c1)F 25341626
11902 8269 8 None - 1 Human 8.3 pEC50 = 8.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 465 7 2 5 3.9 C[C@H]1CN(Cc2ccc(cc2C)N(C)C(=O)[C@H]2CC[C@@H](CC2)Oc2cc(CO)ccc2)CCN1 35051575
56960876 8269 8 None - 1 Human 8.3 pEC50 = 8.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 465 7 2 5 3.9 C[C@H]1CN(Cc2ccc(cc2C)N(C)C(=O)[C@H]2CC[C@@H](CC2)Oc2cc(CO)ccc2)CCN1 35051575
CHEMBL5201797 8269 8 None - 1 Human 8.3 pEC50 = 8.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 465 7 2 5 3.9 C[C@H]1CN(Cc2ccc(cc2C)N(C)C(=O)[C@H]2CC[C@@H](CC2)Oc2cc(CO)ccc2)CCN1 35051575
139592915 10147 35 None 3 2 Human 8.2 pIC50 = 8.2 Functional
NoneNone
Drug Central 837 13 5 17 2.2 COCCOCO/N=C/1\[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@H](C)[C@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C(=O)O[C@@H]([C@@]([C@@H]([C@H]1C)O)(C)O)CC)C None
1465 10147 35 None 3 2 Human 8.2 pIC50 = 8.2 Functional
NoneNone
Drug Central 837 13 5 17 2.2 COCCOCO/N=C/1\[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@H](C)[C@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C(=O)O[C@@H]([C@@]([C@@H]([C@H]1C)O)(C)O)CC)C None
2410 10147 35 None 3 2 Human 8.2 pIC50 = 8.2 Functional
NoneNone
Drug Central 837 13 5 17 2.2 COCCOCO/N=C/1\[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@H](C)[C@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C(=O)O[C@@H]([C@@]([C@@H]([C@H]1C)O)(C)O)CC)C None
6915744 10147 35 None 3 2 Human 8.2 pIC50 = 8.2 Functional
NoneNone
Drug Central 837 13 5 17 2.2 COCCOCO/N=C/1\[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@H](C)[C@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C(=O)O[C@@H]([C@@]([C@@H]([C@H]1C)O)(C)O)CC)C None
CHEMBL1214185 10147 35 None 3 2 Human 8.2 pIC50 = 8.2 Functional
NoneNone
Drug Central 837 13 5 17 2.2 COCCOCO/N=C/1\[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@H](C)[C@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C(=O)O[C@@H]([C@@]([C@@H]([C@H]1C)O)(C)O)CC)C None
DB00778 10147 35 None 3 2 Human 8.2 pIC50 = 8.2 Functional
NoneNone
Drug Central 837 13 5 17 2.2 COCCOCO/N=C/1\[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@H](C)[C@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C(=O)O[C@@H]([C@@]([C@@H]([C@H]1C)O)(C)O)CC)C None
1048 8366 76 None 2 4 Human 6.0 pIC50 = 6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10381885
1048 8366 76 None 2 4 Human 6.0 pIC50 = 6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 15764739
12560 8366 76 None 2 4 Human 6.0 pIC50 = 6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10381885
12560 8366 76 None 2 4 Human 6.0 pIC50 = 6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 15764739
1456 8366 76 None 2 4 Human 6.0 pIC50 = 6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10381885
1456 8366 76 None 2 4 Human 6.0 pIC50 = 6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 15764739
CHEMBL532 8366 76 None 2 4 Human 6.0 pIC50 = 6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10381885
CHEMBL532 8366 76 None 2 4 Human 6.0 pIC50 = 6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 15764739
DB00199 8366 76 None 2 4 Human 6.0 pIC50 = 6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10381885
DB00199 8366 76 None 2 4 Human 6.0 pIC50 = 6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 15764739
1444 7129 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 697 8 2 11 5.2 CCN([C@H]1C[C@@H](C)O[C@H]([C@@H]1O)O[C@@H]1[C@@H](C)[C@H](O[C@@H]2O[C@@H](C)C[C@](C2)(C)OC)[C@@H](C)C(=O)O[C@@H]([C@@H]([C@@H]([C@H](C2=C(C[C@@]1(C)O2)C)C)O)C)CC)C 15764739
9918079 7129 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 697 8 2 11 5.2 CCN([C@H]1C[C@@H](C)O[C@H]([C@@H]1O)O[C@@H]1[C@@H](C)[C@H](O[C@@H]2O[C@@H](C)C[C@](C2)(C)OC)[C@@H](C)C(=O)O[C@@H]([C@@H]([C@@H]([C@H](C2=C(C[C@@]1(C)O2)C)C)O)C)CC)C 15764739
CHEMBL300049 7129 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 697 8 2 11 5.2 CCN([C@H]1C[C@@H](C)O[C@H]([C@@H]1O)O[C@@H]1[C@@H](C)[C@H](O[C@@H]2O[C@@H](C)C[C@](C2)(C)OC)[C@@H](C)C(=O)O[C@@H]([C@@H]([C@@H]([C@H](C2=C(C[C@@]1(C)O2)C)C)O)C)CC)C 15764739
1466 8609 0 None - 1 Rabbit 8.0 pIC50 = 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11806718
9850904 8609 0 None - 1 Rabbit 8.0 pIC50 = 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11806718
CHEMBL3143516 8609 0 None - 1 Rabbit 8.0 pIC50 = 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11806718
177964 9322 2 None -3 2 Rabbit 8.2 pIC50 = 8.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 755 9 2 13 4.5 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@H]([C@]2(OC(=C(C)C2)[C@@H](C(=O)[C@]1(C)OC)C)C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C(C)C)C 10081621
3511 9322 2 None -3 2 Rabbit 8.2 pIC50 = 8.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 755 9 2 13 4.5 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@H]([C@]2(OC(=C(C)C2)[C@@H](C(=O)[C@]1(C)OC)C)C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C(C)C)C 10081621
CHEMBL1778156 9322 2 None -3 2 Rabbit 8.2 pIC50 = 8.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 755 9 2 13 4.5 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@H]([C@]2(OC(=C(C)C2)[C@@H](C(=O)[C@]1(C)OC)C)C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C(C)C)C 10081621
1447 9256 0 None - 1 Human 4.7 pIC50 None 4.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 747 8 5 14 2.2 CCN(C1CC(C)OC(C1O)OC1C(C)C(OC2OC(C)C(C(C2)(C)OC)O)C(C)C(=O)OC(CC)C(C(C(C(=O)C(CC1(C)O)C)C)O)(C)O)C 15764739
14487390 9256 0 None - 1 Human 4.7 pIC50 None 4.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 747 8 5 14 2.2 CCN(C1CC(C)OC(C1O)OC1C(C)C(OC2OC(C)C(C(C2)(C)OC)O)C(C)C(=O)OC(CC)C(C(C(C(=O)C(CC1(C)O)C)C)O)(C)O)C 15764739
139592915 10147 35 None 3 2 Human 6.2 pIC50 None 6.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 837 13 5 17 2.2 COCCOCO/N=C/1\[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@H](C)[C@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C(=O)O[C@@H]([C@@]([C@@H]([C@H]1C)O)(C)O)CC)C 10381885
1465 10147 35 None 3 2 Human 6.2 pIC50 None 6.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 837 13 5 17 2.2 COCCOCO/N=C/1\[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@H](C)[C@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C(=O)O[C@@H]([C@@]([C@@H]([C@H]1C)O)(C)O)CC)C 10381885
2410 10147 35 None 3 2 Human 6.2 pIC50 None 6.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 837 13 5 17 2.2 COCCOCO/N=C/1\[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@H](C)[C@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C(=O)O[C@@H]([C@@]([C@@H]([C@H]1C)O)(C)O)CC)C 10381885
6915744 10147 35 None 3 2 Human 6.2 pIC50 None 6.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 837 13 5 17 2.2 COCCOCO/N=C/1\[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@H](C)[C@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C(=O)O[C@@H]([C@@]([C@@H]([C@H]1C)O)(C)O)CC)C 10381885
CHEMBL1214185 10147 35 None 3 2 Human 6.2 pIC50 None 6.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 837 13 5 17 2.2 COCCOCO/N=C/1\[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@H](C)[C@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C(=O)O[C@@H]([C@@]([C@@H]([C@H]1C)O)(C)O)CC)C 10381885
DB00778 10147 35 None 3 2 Human 6.2 pIC50 None 6.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 837 13 5 17 2.2 COCCOCO/N=C/1\[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@H](C)[C@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C(=O)O[C@@H]([C@@]([C@@H]([C@H]1C)O)(C)O)CC)C 10381885
1448 9257 34 None -2 2 Human 6.3 pIC50 None 6.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 715 7 4 13 2.9 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@H]([C@@]2(OC(=C(C)C2)[C@@H]([C@H]([C@]1(C)O)O)C)C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C)C 15764739
83954 9257 34 None -2 2 Human 6.3 pIC50 None 6.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 715 7 4 13 2.9 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@H]([C@@]2(OC(=C(C)C2)[C@@H]([C@H]([C@]1(C)O)O)C)C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C)C 15764739
CHEMBL300004 9257 34 None -2 2 Human 6.3 pIC50 None 6.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 715 7 4 13 2.9 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@H]([C@@]2(OC(=C(C)C2)[C@@H]([C@H]([C@]1(C)O)O)C)C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C)C 15764739
10032648 9258 0 None - 1 Human 6.5 pIC50 None 6.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 699 7 3 12 3.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@H]([C@]2(OC(=C(C)C2)[C@@H]([C@H]([C@@H]1C)O)C)C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C)C 15764739
1449 9258 0 None - 1 Human 6.5 pIC50 None 6.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 699 7 3 12 3.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@H]([C@]2(OC(=C(C)C2)[C@@H]([C@H]([C@@H]1C)O)C)C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C)C 15764739
1445 8332 0 None - 1 Human 6.6 pIC50 None 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 729 8 4 13 3.3 CCN([C@H]1C[C@@H](C)O[C@H]([C@@H]1O)O[C@@H]1[C@@H](C)[C@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@@H](C)C(=O)O[C@@H]([C@@]([C@@H]([C@H](C2=C(C[C@]1(C)O2)C)C)O)(C)O)CC)C 15764739
184178 8332 0 None - 1 Human 6.6 pIC50 None 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 729 8 4 13 3.3 CCN([C@H]1C[C@@H](C)O[C@H]([C@@H]1O)O[C@@H]1[C@@H](C)[C@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@@H](C)C(=O)O[C@@H]([C@@]([C@@H]([C@H](C2=C(C[C@]1(C)O2)C)C)O)(C)O)CC)C 15764739
1460 9377 0 None - 1 Human 6.8 pIC50 None 6.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10381885
155817408 9377 0 None - 1 Human 6.8 pIC50 None 6.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10381885
10259168 8980 0 None - 1 Human 7.2 pIC50 None 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 699 7 3 12 3.9 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)C[C@](C2)(C)OC)[C@H](C)[C@H]([C@@]2(OC(=C(C)C2)[C@@H]([C@H]([C@]1(C)O)O)C)C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C)C 15764739
1446 8980 0 None - 1 Human 7.2 pIC50 None 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 699 7 3 12 3.9 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)C[C@](C2)(C)OC)[C@H](C)[C@H]([C@@]2(OC(=C(C)C2)[C@@H]([C@H]([C@]1(C)O)O)C)C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C)C 15764739
CHEMBL51522 8980 0 None - 1 Human 7.2 pIC50 None 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 699 7 3 12 3.9 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)C[C@](C2)(C)OC)[C@H](C)[C@H]([C@@]2(OC(=C(C)C2)[C@@H]([C@H]([C@]1(C)O)O)C)C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C)C 15764739
1464 9381 0 None - 1 Human 7.5 pIC50 None 7.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10381885
155817411 9381 0 None - 1 Human 7.5 pIC50 None 7.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10381885
1454 9879 0 None - 1 Human 8.9 pIC50 None 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10381885
101650014 9079 0 None - 1 Human 9.0 pIC50 None 9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10381885
1453 9079 0 None - 1 Human 9.0 pIC50 None 9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10381885
16198245 9079 0 None - 1 Human 9.0 pIC50 None 9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10381885
91898971 9079 0 None - 1 Human 9.0 pIC50 None 9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10381885
101930759 9378 0 None - 1 Human 9.0 pIC50 None 9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10381885
1461 9378 0 None - 1 Human 9.0 pIC50 None 9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10381885
1457 9375 0 None - 1 Human 9.3 pIC50 None 9.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10381885
155817406 9375 0 None - 1 Human 9.3 pIC50 None 9.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10381885
16139289 9375 0 None - 1 Human 9.3 pIC50 None 9.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10381885
71311666 9375 0 None - 1 Human 9.3 pIC50 None 9.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10381885
1462 9379 0 None - 1 Human 9.5 pIC50 None 9.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10381885
155817409 9379 0 None - 1 Human 9.5 pIC50 None 9.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10381885
1463 9380 0 None - 1 Human 9.5 pIC50 None 9.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10381885
155817410 9380 0 None - 1 Human 9.5 pIC50 None 9.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10381885
1455 9605 0 None - 1 Human 9.5 pIC50 None 9.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10381885
1459 9374 0 None - 1 Human 9.7 pIC50 None 9.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10381885
155817407 9374 0 None - 1 Human 9.7 pIC50 None 9.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10381885




Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
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DOI

103 10925 61 None - 53 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
2875 10925 61 None - 53 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
5736 10925 61 None - 53 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
CHEMBL285802 10925 61 None - 53 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
DB09225 10925 61 None - 53 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
1385580 36049 76 None - 5 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 426 7 1 4 4.1 O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1 10.1038/s41467-023-40064-9
4615 36049 76 None - 5 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 426 7 1 4 4.1 O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1 10.1038/s41467-023-40064-9
CHEMBL13828 36049 76 None - 5 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 426 7 1 4 4.1 O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1 10.1038/s41467-023-40064-9
392622 63086 95 None - 4 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 720 17 4 9 5.9 CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1 10.1038/s41467-023-40064-9
CHEMBL163 63086 95 None - 4 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 720 17 4 9 5.9 CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1 10.1038/s41467-023-40064-9
26987 7736 33 None - 21 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 343 6 0 2 5.1 Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C 10.1038/s41467-023-40064-9
6063 7736 33 None - 21 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 343 6 0 2 5.1 Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C 10.1038/s41467-023-40064-9
671 7736 33 None - 21 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 343 6 0 2 5.1 Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C 10.1038/s41467-023-40064-9
CHEMBL1626 7736 33 None - 21 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 343 6 0 2 5.1 Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C 10.1038/s41467-023-40064-9
DB00283 7736 33 None - 21 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 343 6 0 2 5.1 Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C 10.1038/s41467-023-40064-9
65866 101039 73 None - 0 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 611 12 1 8 6.5 COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)(C)CN(C)CCC(c2ccccc2)c2ccccc2)C1c1cccc([N+](=O)[O-])c1 10.1038/s41467-023-40064-9
CHEMBL250270 101039 73 None - 0 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 611 12 1 8 6.5 COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)(C)CN(C)CCC(c2ccccc2)c2ccccc2)C1c1cccc([N+](=O)[O-])c1 10.1038/s41467-023-40064-9
41684 37995 105 None - 0 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 307 4 1 7 2.2 CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1 10.1038/s41467-023-40064-9
CHEMBL1401 37995 105 None - 0 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 307 4 1 7 2.2 CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1 10.1038/s41467-023-40064-9
127151 42104 18 None - 10 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 313 6 1 4 3.2 CCOc1ccccc1OC(c1ccccc1)C1CNCCO1 10.1038/s41467-023-40064-9
3022645 42104 18 None - 10 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 313 6 1 4 3.2 CCOc1ccccc1OC(c1ccccc1)C1CNCCO1 10.1038/s41467-023-40064-9
CHEMBL14370 42104 18 None - 10 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 313 6 1 4 3.2 CCOc1ccccc1OC(c1ccccc1)C1CNCCO1 10.1038/s41467-023-40064-9
10184665 10763 51 None - 0 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 485 16 4 6 4.6 OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O 10.1038/s41467-023-40064-9
4799 10763 51 None - 0 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 485 16 4 6 4.6 OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O 10.1038/s41467-023-40064-9
7353 10763 51 None - 0 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 485 16 4 6 4.6 OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O 10.1038/s41467-023-40064-9
CHEMBL1198857 10763 51 None - 0 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 485 16 4 6 4.6 OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O 10.1038/s41467-023-40064-9
DB09082 10763 51 None - 0 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 485 16 4 6 4.6 OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O 10.1038/s41467-023-40064-9
25382 15929 37 None - 0 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 291 3 0 1 4.7 CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21 10.1038/s41467-023-40064-9
CHEMBL110094 15929 37 None - 0 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 291 3 0 1 4.7 CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21 10.1038/s41467-023-40064-9
24826799 17570 104 None - 0 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 532 4 1 6 4.5 Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 10.1038/s41467-023-40064-9
CHEMBL1171837 17570 104 None - 0 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 532 4 1 6 4.5 Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 10.1038/s41467-023-40064-9
16722836 25757 99 None - 0 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 524 10 3 8 4.8 Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(S(=O)(=O)NC(C)(C)C)c1 10.1038/s41467-023-40064-9
CHEMBL1287853 25757 99 None - 0 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 524 10 3 8 4.8 Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(S(=O)(=O)NC(C)(C)C)c1 10.1038/s41467-023-40064-9
3784 63946 101 None - 0 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 371 4 1 8 2.6 COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)C)C1c1cccc2nonc12 10.1038/s41467-023-40064-9
CHEMBL1648 63946 101 None - 0 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 371 4 1 8 2.6 COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)C)C1c1cccc2nonc12 10.1038/s41467-023-40064-9
4942 12490 50 None - 0 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 367 7 0 4 4.0 CCCOC(C(=O)OC1CCN(C)CC1)(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL1078261 12490 50 None - 0 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 367 7 0 4 4.0 CCCOC(C(=O)OC1CCN(C)CC1)(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
3191 109635 97 None - 25 Human 6.8 pAC50 = 6.8 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 469 9 0 3 7.2 CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 10.1038/s41467-023-40064-9
CHEMBL305660 109635 97 None - 25 Human 6.8 pAC50 = 6.8 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 469 9 0 3 7.2 CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 10.1038/s41467-023-40064-9
176 7186 66 None - 31 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 10.1038/s41467-023-40064-9
2157 7186 66 None - 31 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 10.1038/s41467-023-40064-9
2566 7186 66 None - 31 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 10.1038/s41467-023-40064-9
CHEMBL633 7186 66 None - 31 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 10.1038/s41467-023-40064-9
DB01118 7186 66 None - 31 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 10.1038/s41467-023-40064-9
65948 25328 109 None - 0 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 582 9 2 9 4.7 CC1=C(C(=O)OC(C)C)C(c2cccc([N+](=O)[O-])c2)C(C(=O)OC2CN(C(c3ccccc3)c3ccccc3)C2)=C(N)N1 10.1038/s41467-023-40064-9
CHEMBL1275868 25328 109 None - 0 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 582 9 2 9 4.7 CC1=C(C(=O)OC(C)C)C(c2cccc([N+](=O)[O-])c2)C(C(=O)OC2CN(C(c3ccccc3)c3ccccc3)C2)=C(N)N1 10.1038/s41467-023-40064-9
5284535 65885 26 None - 0 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 392 2 3 5 1.9 C[C@]12C=CC(=O)C=C1C(Cl)=C[C@@H]1[C@@H]2[C@@H](O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)CO 10.1038/s41467-023-40064-9
CHEMBL1697832 65885 26 None - 0 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 392 2 3 5 1.9 C[C@]12C=CC(=O)C=C1C(Cl)=C[C@@H]1[C@@H]2[C@@H](O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)CO 10.1038/s41467-023-40064-9
154257 185398 67 None - 0 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 470 7 2 5 6.3 Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12 10.1038/s41467-023-40064-9
CHEMBL46740 185398 67 None - 0 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 470 7 2 5 6.3 Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12 10.1038/s41467-023-40064-9
11626560 207716 94 None - 0 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 449 5 2 6 5.0 C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl 10.1038/s41467-023-40064-9
CHEMBL601719 207716 94 None - 0 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 449 5 2 6 5.0 C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl 10.1038/s41467-023-40064-9
135409453 10545 41 None - 2 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 301 7 3 3 2.6 CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N 10.1038/s41467-023-40064-9
226 10545 41 None - 2 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 301 7 3 3 2.6 CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N 10.1038/s41467-023-40064-9
CHEMBL76370 10545 41 None - 2 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 301 7 3 3 2.6 CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N 10.1038/s41467-023-40064-9
65709 66655 39 None - 0 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 365 8 0 5 3.3 CCN(CC)CCn1c(=O)c(Cc2ccc(OC)cc2)nc2ccccc21 10.1038/s41467-023-40064-9
CHEMBL1729803 66655 39 None - 0 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 365 8 0 5 3.3 CCN(CC)CCn1c(=O)c(Cc2ccc(OC)cc2)nc2ccccc21 10.1038/s41467-023-40064-9
25181577 84994 56 None - 0 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 574 9 2 9 5.0 CCOC(=O)[C@@H](N)Cc1ccc(-c2cc(O[C@H](c3ccc(Cl)cc3-n3ccc(C)n3)C(F)(F)F)nc(N)n2)cc1 10.1038/s41467-023-40064-9
CHEMBL2105695 84994 56 None - 0 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 574 9 2 9 5.0 CCOC(=O)[C@@H](N)Cc1ccc(-c2cc(O[C@H](c3ccc(Cl)cc3-n3ccc(C)n3)C(F)(F)F)nc(N)n2)cc1 10.1038/s41467-023-40064-9
16362 9899 71 None - 29 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
2172 9899 71 None - 29 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
90 9899 71 None - 29 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
CHEMBL1423 9899 71 None - 29 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
DB01100 9899 71 None - 29 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
240 7731 43 None - 25 Human 5.8 pAC50 = 5.8 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N 10.1038/s41467-023-40064-9
2769 7731 43 None - 25 Human 5.8 pAC50 = 5.8 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N 10.1038/s41467-023-40064-9
44279790 7731 43 None - 25 Human 5.8 pAC50 = 5.8 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N 10.1038/s41467-023-40064-9
660 7731 43 None - 25 Human 5.8 pAC50 = 5.8 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N 10.1038/s41467-023-40064-9
CHEMBL1729 7731 43 None - 25 Human 5.8 pAC50 = 5.8 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N 10.1038/s41467-023-40064-9
CHEMBL560739 7731 43 None - 25 Human 5.8 pAC50 = 5.8 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N 10.1038/s41467-023-40064-9
DB00604 7731 43 None - 25 Human 5.8 pAC50 = 5.8 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N 10.1038/s41467-023-40064-9
68617 212306 62 None - 26 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 305 2 1 1 5.2 CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21 10.1038/s41467-023-40064-9
CHEMBL1709 212306 62 None - 26 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 305 2 1 1 5.2 CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21 10.1038/s41467-023-40064-9
CHEMBL809 212306 62 None - 26 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 305 2 1 1 5.2 CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21 10.1038/s41467-023-40064-9
11976 7707 59 None - 24 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 315 3 0 2 5.2 CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl 10.1038/s41467-023-40064-9
667467 7707 59 None - 24 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 315 3 0 2 5.2 CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl 10.1038/s41467-023-40064-9
CHEMBL908 7707 59 None - 24 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 315 3 0 2 5.2 CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl 10.1038/s41467-023-40064-9
DB01239 7707 59 None - 24 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 315 3 0 2 5.2 CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl 10.1038/s41467-023-40064-9
275196 132451 52 None - 0 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 413 4 0 8 2.9 COc1ccc2c(c1OC)C(=O)O[C@@H]2[C@H]1c2c(cc3c(c2OC)OCO3)CCN1C 10.1038/s41467-023-40064-9
CHEMBL364713 132451 52 None - 0 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 413 4 0 8 2.9 COc1ccc2c(c1OC)C(=O)O[C@@H]2[C@H]1c2c(cc3c(c2OC)OCO3)CCN1C 10.1038/s41467-023-40064-9
2351 11072 49 None - 0 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 366 10 0 3 4.8 CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1 10.1038/s41467-023-40064-9
CHEMBL1008 11072 49 None - 0 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 366 10 0 3 4.8 CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1 10.1038/s41467-023-40064-9
CHEMBL1257078 11072 49 None - 0 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 366 10 0 3 4.8 CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1 10.1038/s41467-023-40064-9
4150 7575 39 None - 12 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 314 6 2 2 5.8 CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C 10.1038/s41467-023-40064-9
5288 7575 39 None - 12 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 314 6 2 2 5.8 CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C 10.1038/s41467-023-40064-9
644019 7575 39 None - 12 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 314 6 2 2 5.8 CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C 10.1038/s41467-023-40064-9
CHEMBL190461 7575 39 None - 12 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 314 6 2 2 5.8 CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C 10.1038/s41467-023-40064-9
DB09061 7575 39 None - 12 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 314 6 2 2 5.8 CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C 10.1038/s41467-023-40064-9
118422671 9533 65 None - 4 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
1887 9533 65 None - 4 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
71301 9533 65 None - 4 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
7246 9533 65 None - 4 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
CHEMBL434394 9533 65 None - 4 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
DB04861 9533 65 None - 4 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
104850 10103 96 None - 6 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 462 4 1 4 5.9 Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 10.1038/s41467-023-40064-9
4150 10103 96 None - 6 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 462 4 1 4 5.9 Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 10.1038/s41467-023-40064-9
743 10103 96 None - 6 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 462 4 1 4 5.9 Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 10.1038/s41467-023-40064-9
CHEMBL111 10103 96 None - 6 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 462 4 1 4 5.9 Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 10.1038/s41467-023-40064-9
DB06155 10103 96 None - 6 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 462 4 1 4 5.9 Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 10.1038/s41467-023-40064-9
3926 214020 40 None - 0 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 491 9 1 3 5.8 Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1038/s41467-023-40064-9
CHEMBL92870 214020 40 None - 0 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 491 9 1 3 5.8 Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1038/s41467-023-40064-9
156419 7725 74 None - 1 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 357 6 1 1 6.1 C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F 10.1038/s41467-023-40064-9
3308 7725 74 None - 1 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 357 6 1 1 6.1 C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F 10.1038/s41467-023-40064-9
647 7725 74 None - 1 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 357 6 1 1 6.1 C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F 10.1038/s41467-023-40064-9
CHEMBL1201284 7725 74 None - 1 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 357 6 1 1 6.1 C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F 10.1038/s41467-023-40064-9
DB01012 7725 74 None - 1 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 357 6 1 1 6.1 C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F 10.1038/s41467-023-40064-9
2540 11173 111 None - 4 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 610 10 1 11 6.3 CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1038/s41467-023-40064-9
CHEMBL1014 11173 111 None - 4 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 610 10 1 11 6.3 CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1038/s41467-023-40064-9
135564886 21265 5 None - 0 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
135673376 21265 5 None - 0 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
137157436 21265 5 None - 0 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
145948239 21265 5 None - 0 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
71587099 21265 5 None - 0 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
CHEMBL1201304 21265 5 None - 0 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
51755 64180 54 None - 0 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 454 8 0 4 7.3 Clc1ccc(C(Cn2ccnc2)OCc2ccc(Sc3ccccc3)cc2)c(Cl)c1 10.1038/s41467-023-40064-9
CHEMBL1651990 64180 54 None - 0 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 454 8 0 4 7.3 Clc1ccc(C(Cn2ccnc2)OCc2ccc(Sc3ccccc3)cc2)c(Cl)c1 10.1038/s41467-023-40064-9
44112 128068 48 None - 7 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 380 7 2 4 4.5 Cc1cc2c(OCC(CNC(C)(C)C)OC(=O)c3ccccc3)cccc2[nH]1 10.1038/s41467-023-40064-9
CHEMBL357995 128068 48 None - 7 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 380 7 2 4 4.5 Cc1cc2c(OCC(CNC(C)(C)C)OC(=O)c3ccccc3)cccc2[nH]1 10.1038/s41467-023-40064-9
1048 8366 76 None - 1 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1038/s41467-023-40064-9
12560 8366 76 None - 1 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1038/s41467-023-40064-9
1456 8366 76 None - 1 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1038/s41467-023-40064-9
CHEMBL532 8366 76 None - 1 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1038/s41467-023-40064-9
DB00199 8366 76 None - 1 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1038/s41467-023-40064-9
5282138 179902 95 None - 0 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 492 10 1 8 4.3 COCCOC(=O)C1=C(C)NC(C)=C(C(=O)OC/C=C/c2ccccc2)C1c1cccc([N+](=O)[O-])c1 10.1038/s41467-023-40064-9
CHEMBL452076 179902 95 None - 0 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 492 10 1 8 4.3 COCCOC(=O)C1=C(C)NC(C)=C(C(=O)OC/C=C/c2ccccc2)C1c1cccc([N+](=O)[O-])c1 10.1038/s41467-023-40064-9
6436173 61890 45 None - 0 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 785 2 5 13 6.2 CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c5c(nc6cc(C)ccn65)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C 10.1038/s41467-023-40064-9
CHEMBL1617 61890 45 None - 0 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 785 2 5 13 6.2 CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c5c(nc6cc(C)ccn65)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C 10.1038/s41467-023-40064-9
32798 16948 69 None - 0 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 466 4 1 5 4.1 CCC(=O)O[C@]1(C(=O)CCl)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C 10.1038/s41467-023-40064-9
CHEMBL1159650 16948 69 None - 0 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 466 4 1 5 4.1 CCC(=O)O[C@]1(C(=O)CCl)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C 10.1038/s41467-023-40064-9
16363 7383 53 None - 7 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 381 6 1 4 3.8 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
312 7383 53 None - 7 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 381 6 1 4 3.8 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
9215 7383 53 None - 7 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 381 6 1 4 3.8 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
CHEMBL297302 7383 53 None - 7 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 381 6 1 4 3.8 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
DB12867 7383 53 None - 7 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 381 6 1 4 3.8 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
17676 13844 29 None - 3 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 411 7 1 6 3.5 CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2 10.1038/s41467-023-40064-9
5281082 13844 29 None - 3 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 411 7 1 6 3.5 CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2 10.1038/s41467-023-40064-9
CHEMBL1085 13844 29 None - 3 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 411 7 1 6 3.5 CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2 10.1038/s41467-023-40064-9
3401 85058 80 None - 0 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 346 4 0 2 5.0 Fc1ccc(C(c2ccccc2)(c2ccccc2F)n2ccnc2)cc1 10.1038/s41467-023-40064-9
CHEMBL2107430 85058 80 None - 0 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 346 4 0 2 5.0 Fc1ccc(C(c2ccccc2)(c2ccccc2F)n2ccnc2)cc1 10.1038/s41467-023-40064-9
54682461 91461 62 None - 0 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 602 11 2 6 7.3 CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)C(=O)O1 10.1038/s41467-023-40064-9
CHEMBL222559 91461 62 None - 0 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 602 11 2 6 7.3 CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)C(=O)O1 10.1038/s41467-023-40064-9
4413 104849 57 None - 0 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 347 4 5 4 2.6 N=C(N)Nc1ccc(C(=O)Oc2ccc3cc(C(=N)N)ccc3c2)cc1 10.1038/s41467-023-40064-9
CHEMBL273264 104849 57 None - 0 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 347 4 5 4 2.6 N=C(N)Nc1ccc(C(=O)Oc2ccc3cc(C(=N)N)ccc3c2)cc1 10.1038/s41467-023-40064-9
4495 203314 92 None - 29 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 308 5 1 5 2.8 CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1 10.1038/s41467-023-40064-9
CHEMBL56367 203314 92 None - 29 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 308 5 1 5 2.8 CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1 10.1038/s41467-023-40064-9
2335 18620 22 None - 12 Human 5.6 pAC50 = 5.6 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 10.1038/s41467-023-40064-9
8478 18620 22 None - 12 Human 5.6 pAC50 = 5.6 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 10.1038/s41467-023-40064-9
CHEMBL1182210 18620 22 None - 12 Human 5.6 pAC50 = 5.6 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 10.1038/s41467-023-40064-9
CHEMBL221753 18620 22 None - 12 Human 5.6 pAC50 = 5.6 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 10.1038/s41467-023-40064-9
216239 30567 118 None - 7 Human 5.6 pAC50 = 5.6 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 464 5 3 4 5.6 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 10.1038/s41467-023-40064-9
CHEMBL1200485 30567 118 None - 7 Human 5.6 pAC50 = 5.6 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 464 5 3 4 5.6 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 10.1038/s41467-023-40064-9
CHEMBL1336 30567 118 None - 7 Human 5.6 pAC50 = 5.6 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 464 5 3 4 5.6 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 10.1038/s41467-023-40064-9
3474 44875 57 None - 0 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 372 6 3 6 3.1 O=C(OCC(O)CO)c1ccccc1Nc1ccnc2cc(Cl)ccc12 10.1038/s41467-023-40064-9
CHEMBL146095 44875 57 None - 0 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 372 6 3 6 3.1 O=C(OCC(O)CO)c1ccccc1Nc1ccnc2cc(Cl)ccc12 10.1038/s41467-023-40064-9
169870 21213 67 None - 1 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 428 6 0 4 6.0 CCCCCC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1038/s41467-023-40064-9
CHEMBL1200848 21213 67 None - 1 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 428 6 0 4 6.0 CCCCCC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1038/s41467-023-40064-9
216416 118358 48 None - 0 Human 5.5 pAC50 = 5.5 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 413 6 1 3 5.7 Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1 10.1038/s41467-023-40064-9
CHEMBL328190 118358 48 None - 0 Human 5.5 pAC50 = 5.5 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 413 6 1 3 5.7 Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1 10.1038/s41467-023-40064-9
4746 211670 31 None - 4 Human 4.5 pAC50 = 4.5 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 277 4 1 1 5.3 C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1 10.1038/s41467-023-40064-9
CHEMBL1334033 211670 31 None - 4 Human 4.5 pAC50 = 4.5 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 277 4 1 1 5.3 C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1 10.1038/s41467-023-40064-9
CHEMBL75880 211670 31 None - 4 Human 4.5 pAC50 = 4.5 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 277 4 1 1 5.3 C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1 10.1038/s41467-023-40064-9
3149 19386 15 None - 0 Human 5.5 pAC50 = 5.5 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 334 15 0 1 6.1 CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1 10.1038/s41467-023-40064-9
CHEMBL1187011 19386 15 None - 0 Human 5.5 pAC50 = 5.5 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 334 15 0 1 6.1 CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1 10.1038/s41467-023-40064-9
60065 91144 6 None - 0 Human 5.5 pAC50 = 5.5 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 505 7 1 8 4.2 COC(=O)C1=C(C)NC(C)=C(C(=O)O[C@@H]2CCCN(Cc3ccccc3)C2)C1c1cccc([N+](=O)[O-])c1 10.1038/s41467-023-40064-9
CHEMBL2218858 91144 6 None - 0 Human 5.5 pAC50 = 5.5 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 505 7 1 8 4.2 COC(=O)C1=C(C)NC(C)=C(C(=O)O[C@@H]2CCCN(Cc3ccccc3)C2)C1c1cccc([N+](=O)[O-])c1 10.1038/s41467-023-40064-9
131411 22164 70 None - 0 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 476 7 1 6 5.2 CCOC(=O)c1c(CSc2ccccc2)n(C)c2cc(Br)c(O)c(CN(C)C)c12 10.1038/s41467-023-40064-9
28446253 22164 70 None - 0 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 476 7 1 6 5.2 CCOC(=O)c1c(CSc2ccccc2)n(C)c2cc(Br)c(O)c(CN(C)C)c12 10.1038/s41467-023-40064-9
CHEMBL1214598 22164 70 None - 0 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 476 7 1 6 5.2 CCOC(=O)c1c(CSc2ccccc2)n(C)c2cc(Br)c(O)c(CN(C)C)c12 10.1038/s41467-023-40064-9
2435 10362 83 None - 48 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O 10.1038/s41467-023-40064-9
60149 10362 83 None - 48 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O 10.1038/s41467-023-40064-9
98 10362 83 None - 48 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O 10.1038/s41467-023-40064-9
CHEMBL12713 10362 83 None - 48 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O 10.1038/s41467-023-40064-9
DB06144 10362 83 None - 48 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O 10.1038/s41467-023-40064-9
11643449 96730 3 None - 0 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 753 6 5 10 2.7 CC[C@]1(O)C[C@@H]2CN(CCc3c([nH]c4ccccc34)[C@@](C(=O)OC)(c3cc4c(cc3OC)N(C)[C@H]3[C@@](O)(C(N)=O)[C@H](O)[C@]5(CC)C=CCN6CC[C@]43[C@@H]65)C2)C1 10.1038/s41467-023-40064-9
CHEMBL238071 96730 3 None - 0 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 753 6 5 10 2.7 CC[C@]1(O)C[C@@H]2CN(CCc3c([nH]c4ccccc34)[C@@](C(=O)OC)(c3cc4c(cc3OC)N(C)[C@H]3[C@@](O)(C(N)=O)[C@H](O)[C@]5(CC)C=CCN6CC[C@]43[C@@H]65)C2)C1 10.1038/s41467-023-40064-9
202 8290 77 None - 33 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 10.1038/s41467-023-40064-9
60835 8290 77 None - 33 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 10.1038/s41467-023-40064-9
972 8290 77 None - 33 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 10.1038/s41467-023-40064-9
CHEMBL1175 8290 77 None - 33 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 10.1038/s41467-023-40064-9
DB00476 8290 77 None - 33 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 10.1038/s41467-023-40064-9
72093 41835 9 None - 0 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 483 16 1 4 6.3 CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1 10.1038/s41467-023-40064-9
CHEMBL1433361 41835 9 None - 0 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 483 16 1 4 6.3 CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1 10.1038/s41467-023-40064-9
CHEMBL2103773 41835 9 None - 0 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 483 16 1 4 6.3 CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1 10.1038/s41467-023-40064-9
25077405 9492 0 None - 1 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL None None None None 10.1038/s41467-023-40064-9
3902 9492 0 None - 1 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL None None None None 10.1038/s41467-023-40064-9
CHEMBL1201309 9492 0 None - 1 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL None None None None 10.1038/s41467-023-40064-9
DB00666 9492 0 None - 1 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL None None None None 10.1038/s41467-023-40064-9
2247 7293 81 None - 42 Human 6.2 pAC50 = 6.2 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 10.1038/s41467-023-40064-9
249 7293 81 None - 42 Human 6.2 pAC50 = 6.2 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 10.1038/s41467-023-40064-9
2603 7293 81 None - 42 Human 6.2 pAC50 = 6.2 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 10.1038/s41467-023-40064-9
CHEMBL296419 7293 81 None - 42 Human 6.2 pAC50 = 6.2 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 10.1038/s41467-023-40064-9
DB00637 7293 81 None - 42 Human 6.2 pAC50 = 6.2 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 10.1038/s41467-023-40064-9
148192 17192 81 None - 0 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 704 14 5 9 4.2 COC(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)CN(Cc1ccc(-c2ccccn2)cc1)NC(=O)[C@@H](NC(=O)OC)C(C)(C)C)C(C)(C)C 10.1038/s41467-023-40064-9
CHEMBL1163 17192 81 None - 0 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 704 14 5 9 4.2 COC(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)CN(Cc1ccc(-c2ccccn2)cc1)NC(=O)[C@@H](NC(=O)OC)C(C)(C)C)C(C)(C)C 10.1038/s41467-023-40064-9
71496458 122342 87 None - 0 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 499 10 2 8 4.5 C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C 10.1038/s41467-023-40064-9
CHEMBL3353410 122342 87 None - 0 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 499 10 2 8 4.5 C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C 10.1038/s41467-023-40064-9
65016 16981 86 None - 0 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 505 11 3 7 2.4 CC(C)CN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)O[C@H]1CCOC1)S(=O)(=O)c1ccc(N)cc1 10.1038/s41467-023-40064-9
CHEMBL116 16981 86 None - 0 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 505 11 3 7 2.4 CC(C)CN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)O[C@H]1CCOC1)S(=O)(=O)c1ccc(N)cc1 10.1038/s41467-023-40064-9
5329102 201505 86 None - 0 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 398 7 3 3 3.3 CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C 10.1038/s41467-023-40064-9
CHEMBL535 201505 86 None - 0 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 398 7 3 3 3.3 CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C 10.1038/s41467-023-40064-9
2585 7590 103 None - 22 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
522 7590 103 None - 22 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
551 7590 103 None - 22 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
CHEMBL723 7590 103 None - 22 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
DB01136 7590 103 None - 22 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
444029 174536 10 None - 0 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 509 6 2 9 2.0 C=C[C@@]1(C)CC(=O)[C@]2(O)[C@@]3(C)[C@@H](O)CCC(C)(C)[C@@H]3[C@H](OC(=O)CCN(C)C)[C@H](OC(C)=O)[C@@]2(C)O1 10.1038/s41467-023-40064-9
CHEMBL4303178 174536 10 None - 0 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 509 6 2 9 2.0 C=C[C@@]1(C)CC(=O)[C@]2(O)[C@@]3(C)[C@@H](O)CCC(C)(C)[C@@H]3[C@H](OC(=O)CCN(C)C)[C@H](OC(C)=O)[C@@]2(C)O1 10.1038/s41467-023-40064-9
2713 212050 82 None - 0 Human 6.1 pAC50 = 6.1 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 504 9 10 4 4.2 N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 10.1038/s41467-023-40064-9
5353524 212050 82 None - 0 Human 6.1 pAC50 = 6.1 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 504 9 10 4 4.2 N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 10.1038/s41467-023-40064-9
5360566 212050 82 None - 0 Human 6.1 pAC50 = 6.1 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 504 9 10 4 4.2 N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 10.1038/s41467-023-40064-9
88536661 212050 82 None - 0 Human 6.1 pAC50 = 6.1 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 504 9 10 4 4.2 N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 10.1038/s41467-023-40064-9
9552079 212050 82 None - 0 Human 6.1 pAC50 = 6.1 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 504 9 10 4 4.2 N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 10.1038/s41467-023-40064-9
CHEMBL1330113 212050 82 None - 0 Human 6.1 pAC50 = 6.1 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 504 9 10 4 4.2 N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 10.1038/s41467-023-40064-9
CHEMBL790 212050 82 None - 0 Human 6.1 pAC50 = 6.1 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 504 9 10 4 4.2 N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 10.1038/s41467-023-40064-9
214 10632 58 None - 30 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 10.1038/s41467-023-40064-9
2740 10632 58 None - 30 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 10.1038/s41467-023-40064-9
5566 10632 58 None - 30 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 10.1038/s41467-023-40064-9
66064 10632 58 None - 30 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 10.1038/s41467-023-40064-9
CHEMBL422 10632 58 None - 30 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 10.1038/s41467-023-40064-9
DB00831 10632 58 None - 30 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 10.1038/s41467-023-40064-9
68867 84948 38 None - 0 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 402 7 2 6 3.1 CCOc1cc(N)c([N+](=O)[O-])cc1C(=O)NC1CCN(CC2CC=CCC2)CC1 10.1038/s41467-023-40064-9
CHEMBL2104523 84948 38 None - 0 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 402 7 2 6 3.1 CCOc1cc(N)c([N+](=O)[O-])cc1C(=O)NC1CCN(CC2CC=CCC2)CC1 10.1038/s41467-023-40064-9
11980903 21264 19 None - 0 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 382 4 0 2 5.3 Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1 10.1038/s41467-023-40064-9
22526 21264 19 None - 0 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 382 4 0 2 5.3 Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1 10.1038/s41467-023-40064-9
5281035 21264 19 None - 0 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 382 4 0 2 5.3 Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL1201303 21264 19 None - 0 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 382 4 0 2 5.3 Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1 10.1038/s41467-023-40064-9
242 7258 124 None - 51 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
34 7258 124 None - 51 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
60795 7258 124 None - 51 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
CHEMBL1112 7258 124 None - 51 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
DB01238 7258 124 None - 51 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
139592915 10147 35 None - 1 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 837 13 5 17 2.2 COCCOCO/N=C/1\[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@H](C)[C@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C(=O)O[C@@H]([C@@]([C@@H]([C@H]1C)O)(C)O)CC)C 10.1038/s41467-023-40064-9
1465 10147 35 None - 1 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 837 13 5 17 2.2 COCCOCO/N=C/1\[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@H](C)[C@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C(=O)O[C@@H]([C@@]([C@@H]([C@H]1C)O)(C)O)CC)C 10.1038/s41467-023-40064-9
2410 10147 35 None - 1 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 837 13 5 17 2.2 COCCOCO/N=C/1\[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@H](C)[C@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C(=O)O[C@@H]([C@@]([C@@H]([C@H]1C)O)(C)O)CC)C 10.1038/s41467-023-40064-9
6915744 10147 35 None - 1 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 837 13 5 17 2.2 COCCOCO/N=C/1\[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@H](C)[C@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C(=O)O[C@@H]([C@@]([C@@H]([C@H]1C)O)(C)O)CC)C 10.1038/s41467-023-40064-9
CHEMBL1214185 10147 35 None - 1 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 837 13 5 17 2.2 COCCOCO/N=C/1\[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@H](C)[C@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C(=O)O[C@@H]([C@@]([C@@H]([C@H]1C)O)(C)O)CC)C 10.1038/s41467-023-40064-9
DB00778 10147 35 None - 1 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 837 13 5 17 2.2 COCCOCO/N=C/1\[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@H](C)[C@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C(=O)O[C@@H]([C@@]([C@@H]([C@H]1C)O)(C)O)CC)C 10.1038/s41467-023-40064-9
445643 104164 69 None - 0 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 803 7 3 12 4.6 C=CC[C@@H]1/C=C(\C)C[C@H](C)C[C@H](OC)[C@H]2O[C@@](O)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@H](/C(C)=C/[C@@H]3CC[C@@H](O)[C@H](OC)C3)[C@H](C)[C@@H](O)CC1=O)[C@H](C)C[C@@H]2OC 10.1038/s41467-023-40064-9
CHEMBL269732 104164 69 None - 0 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 803 7 3 12 4.6 C=CC[C@@H]1/C=C(\C)C[C@H](C)C[C@H](OC)[C@H]2O[C@@](O)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@H](/C(C)=C/[C@@H]3CC[C@@H](O)[C@H](OC)C3)[C@H](C)[C@@H](O)CC1=O)[C@H](C)C[C@@H]2OC 10.1038/s41467-023-40064-9
1222 8445 49 None - 32 Human 5.0 pAC50 = 5 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1038/s41467-023-40064-9
3396 8445 49 None - 32 Human 5.0 pAC50 = 5 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1038/s41467-023-40064-9
85 8445 49 None - 32 Human 5.0 pAC50 = 5 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL46516 8445 49 None - 32 Human 5.0 pAC50 = 5 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1038/s41467-023-40064-9
DB04842 8445 49 None - 32 Human 5.0 pAC50 = 5 Binding
Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1038/s41467-023-40064-9
16752689 195147 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at MLNR (unknown origin)Agonist activity at MLNR (unknown origin)
ChEMBL 568 10 2 4 6.6 COc1cccc(CCN(Cc2ccccc2-c2ccc(CN3C[C@H](C)N[C@H](C)C3)cc2)C(=O)NC2CCCCC2)c1 10.1021/jm301653f
CHEMBL501315 195147 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at MLNR (unknown origin)Agonist activity at MLNR (unknown origin)
ChEMBL 568 10 2 4 6.6 COc1cccc(CCN(Cc2ccccc2-c2ccc(CN3C[C@H](C)N[C@H](C)C3)cc2)C(=O)NC2CCCCC2)c1 10.1021/jm301653f
CHEMBL496391 220862 0 None - 1 Rabbit 9.0 pIC50 = 9.0 Binding
Displacement of [125I]motilin from MTL receptor in rabbit duodenum homogenateDisplacement of [125I]motilin from MTL receptor in rabbit duodenum homogenate
ChEMBL None None None CC(C)[C@@H](C(=O)N[C@@H](Cc1ccc(O)c(C(C)(C)C)c1)C(N)=O)N(C)C(=O)[C@@H](N)Cc1ccccc1 10.1016/j.bmcl.2009.05.059
11018075 107164 0 None - 0 Rabbit 8.8 pIC50 = 8.8 Binding
In vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tissue homogenate
ChEMBL 739 9 1 12 5.6 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)CC(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC 10.1016/S0960-894X(01)80583-7
CHEMBL289955 107164 0 None - 0 Rabbit 8.8 pIC50 = 8.8 Binding
In vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tissue homogenate
ChEMBL 739 9 1 12 5.6 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)CC(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC 10.1016/S0960-894X(01)80583-7
44290233 179605 0 None - 0 Rabbit 8.7 pIC50 = 8.7 Binding
In vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenate
ChEMBL 723 9 0 11 6.6 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)CC(C)O2)C(C)[C@@H](OC2CC(N(C)C(C)C)CC(C)O2)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC 10.1016/S0960-894X(01)80583-7
CHEMBL45141 179605 0 None - 0 Rabbit 8.7 pIC50 = 8.7 Binding
In vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenate
ChEMBL 723 9 0 11 6.6 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)CC(C)O2)C(C)[C@@H](OC2CC(N(C)C(C)C)CC(C)O2)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC 10.1016/S0960-894X(01)80583-7
9956253 194620 0 None - 1 Rabbit 8.7 pIC50 = 8.7 Binding
Displacement of [125I]motilin from MTL receptor in rabbit duodenum homogenateDisplacement of [125I]motilin from MTL receptor in rabbit duodenum homogenate
ChEMBL 467 9 3 4 3.8 CC(C)[C@@H](C(=O)N[C@H](C)Cc1ccc(O)c(C(C)(C)C)c1)N(C)C(=O)[C@@H](N)Cc1ccccc1 10.1016/j.bmcl.2009.05.059
CHEMBL496191 194620 0 None - 1 Rabbit 8.7 pIC50 = 8.7 Binding
Displacement of [125I]motilin from MTL receptor in rabbit duodenum homogenateDisplacement of [125I]motilin from MTL receptor in rabbit duodenum homogenate
ChEMBL 467 9 3 4 3.8 CC(C)[C@@H](C(=O)N[C@H](C)Cc1ccc(O)c(C(C)(C)C)c1)N(C)C(=O)[C@@H](N)Cc1ccccc1 10.1016/j.bmcl.2009.05.059
9895192 84630 0 None - 0 Rabbit 8.0 pIC50 = 8 Binding
Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor
ChEMBL 613 11 0 4 7.6 CC(C)(C)C(=O)N(Cc1ccccc1)[C@@H]1CCC[C@H](CN(C(=O)c2ccc(F)cc2)c2cccc(OCCN3CCCC3)c2)C1 10.1016/j.bmcl.2006.04.017
CHEMBL209301 84630 0 None - 0 Rabbit 8.0 pIC50 = 8 Binding
Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor
ChEMBL 613 11 0 4 7.6 CC(C)(C)C(=O)N(Cc1ccccc1)[C@@H]1CCC[C@H](CN(C(=O)c2ccc(F)cc2)c2cccc(OCCN3CCCC3)c2)C1 10.1016/j.bmcl.2006.04.017
44412981 145118 0 None - 0 Rabbit 8.0 pIC50 = 8 Binding
Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor
ChEMBL 704 11 2 5 7.3 O=C(Nc1ccccc1)N(CC1=C[C@@](Cc2cccc(Cl)c2)(NC(=O)C(Cl)(Cl)Cl)CC1)c1cccc(OCCN2CCOCC2)c1 10.1016/j.bmcl.2006.04.017
CHEMBL377137 145118 0 None - 0 Rabbit 8.0 pIC50 = 8 Binding
Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor
ChEMBL 704 11 2 5 7.3 O=C(Nc1ccccc1)N(CC1=C[C@@](Cc2cccc(Cl)c2)(NC(=O)C(Cl)(Cl)Cl)CC1)c1cccc(OCCN2CCOCC2)c1 10.1016/j.bmcl.2006.04.017
1466 8609 0 None - 0 Rabbit 8.0 pIC50 = 8 Binding
Inhibition of the motilin receptor (MTL-R)Inhibition of the motilin receptor (MTL-R)
ChEMBL None None None None 10.1021/jm010332u
9850904 8609 0 None - 0 Rabbit 8.0 pIC50 = 8 Binding
Inhibition of the motilin receptor (MTL-R)Inhibition of the motilin receptor (MTL-R)
ChEMBL None None None None 10.1021/jm010332u
CHEMBL3143516 8609 0 None - 0 Rabbit 8.0 pIC50 = 8 Binding
Inhibition of the motilin receptor (MTL-R)Inhibition of the motilin receptor (MTL-R)
ChEMBL None None None None 10.1021/jm010332u
10122749 85087 0 None - 0 Rabbit 5.9 pIC50 = 5.9 Binding
Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor
ChEMBL 691 13 1 7 7.2 O=C(Nc1ccccc1)N(CC1CCCC(N(Cc2ccccc2)C(=O)c2cccc([N+](=O)[O-])c2)C1)c1cccc(OCCN2CCOCC2)c1 10.1016/j.bmcl.2006.04.017
CHEMBL210899 85087 0 None - 0 Rabbit 5.9 pIC50 = 5.9 Binding
Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor
ChEMBL 691 13 1 7 7.2 O=C(Nc1ccccc1)N(CC1CCCC(N(Cc2ccccc2)C(=O)c2cccc([N+](=O)[O-])c2)C1)c1cccc(OCCN2CCOCC2)c1 10.1016/j.bmcl.2006.04.017
44583286 200229 0 None - 1 Rabbit 7.9 pIC50 = 7.9 Binding
Displacement of [125I]motilin from MTL receptor in rabbit duodenum homogenateDisplacement of [125I]motilin from MTL receptor in rabbit duodenum homogenate
ChEMBL 564 6 5 6 2.8 CC(C)(C)c1cc(C[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H](N)Cc3ccccc3)CCCCCC(=O)CCNC2=O)ccc1O 10.1016/j.bmcl.2009.05.059
CHEMBL526496 200229 0 None - 1 Rabbit 7.9 pIC50 = 7.9 Binding
Displacement of [125I]motilin from MTL receptor in rabbit duodenum homogenateDisplacement of [125I]motilin from MTL receptor in rabbit duodenum homogenate
ChEMBL 564 6 5 6 2.8 CC(C)(C)c1cc(C[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H](N)Cc3ccccc3)CCCCCC(=O)CCNC2=O)ccc1O 10.1016/j.bmcl.2009.05.059
CHEMBL497004 220863 0 None - 1 Rabbit 7.9 pIC50 = 7.9 Binding
Displacement of [125I]motilin from MTL receptor in rabbit duodenum homogenateDisplacement of [125I]motilin from MTL receptor in rabbit duodenum homogenate
ChEMBL None None None CC(C)(C)c1cc(C[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccccc2)c2ccccc2)C(N)=O)ccc1O 10.1016/j.bmcl.2009.05.059
44412894 145688 0 None - 0 Rabbit 7.9 pIC50 = 7.9 Binding
Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor
ChEMBL 718 12 0 6 7.8 O=C(c1ccc(F)cc1)N(CC1CCCC(N(Cc2cccc([N+](=O)[O-])c2)C(=O)C(Cl)(Cl)Cl)C1)c1cccc(OCCN2CCCC2)c1 10.1016/j.bmcl.2006.04.017
CHEMBL378317 145688 0 None - 0 Rabbit 7.9 pIC50 = 7.9 Binding
Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor
ChEMBL 718 12 0 6 7.8 O=C(c1ccc(F)cc1)N(CC1CCCC(N(Cc2cccc([N+](=O)[O-])c2)C(=O)C(Cl)(Cl)Cl)C1)c1cccc(OCCN2CCCC2)c1 10.1016/j.bmcl.2006.04.017
44380651 126910 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)
ChEMBL 757 9 3 13 4.3 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)OC 10.1016/0960-894X(95)00122-A
CHEMBL351216 126910 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)
ChEMBL 757 9 3 13 4.3 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)OC 10.1016/0960-894X(95)00122-A
44276703 106060 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Compound was tested for in vitro motilin receptor binding affinityCompound was tested for in vitro motilin receptor binding affinity
ChEMBL 715 7 3 13 3.0 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@]2(C)CC(C)C3(O2)O[C@]1(C)[C@H](O)[C@H]3C 10.1016/0960-894X(95)00122-A
CHEMBL281952 106060 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Compound was tested for in vitro motilin receptor binding affinityCompound was tested for in vitro motilin receptor binding affinity
ChEMBL 715 7 3 13 3.0 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@]2(C)CC(C)C3(O2)O[C@]1(C)[C@H](O)[C@H]3C 10.1016/0960-894X(95)00122-A
44276703 106060 0 None - 0 Rabbit 6.8 pIC50 = 6.8 Binding
Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50
ChEMBL 715 7 3 13 3.0 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@]2(C)CC(C)C3(O2)O[C@]1(C)[C@H](O)[C@H]3C 10.1016/S0960-894X(01)80359-0
CHEMBL281952 106060 0 None - 0 Rabbit 6.8 pIC50 = 6.8 Binding
Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50
ChEMBL 715 7 3 13 3.0 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@]2(C)CC(C)C3(O2)O[C@]1(C)[C@H](O)[C@H]3C 10.1016/S0960-894X(01)80359-0
44276703 106060 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)
ChEMBL 715 7 3 13 3.0 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@]2(C)CC(C)C3(O2)O[C@]1(C)[C@H](O)[C@H]3C 10.1016/0960-894X(95)00122-A
CHEMBL281952 106060 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)
ChEMBL 715 7 3 13 3.0 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@]2(C)CC(C)C3(O2)O[C@]1(C)[C@H](O)[C@H]3C 10.1016/0960-894X(95)00122-A
44276703 106060 0 None - 0 Rabbit 6.8 pIC50 = 6.8 Binding
Concentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor bindingConcentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor binding
ChEMBL 715 7 3 13 3.0 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@]2(C)CC(C)C3(O2)O[C@]1(C)[C@H](O)[C@H]3C 10.1016/S0960-894X(01)80359-0
CHEMBL281952 106060 0 None - 0 Rabbit 6.8 pIC50 = 6.8 Binding
Concentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor bindingConcentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor binding
ChEMBL 715 7 3 13 3.0 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@]2(C)CC(C)C3(O2)O[C@]1(C)[C@H](O)[C@H]3C 10.1016/S0960-894X(01)80359-0
11767227 113468 0 None - 0 Rabbit 7.8 pIC50 = 7.8 Binding
Inhibition of the motilin receptor (MTL-R)Inhibition of the motilin receptor (MTL-R)
ChEMBL 607 6 6 6 2.7 CC(C)(C)c1cc(C[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H](N)Cc3ccccc3)CCCCNC(=O)CCCCCNC2=O)ccc1O 10.1021/jm010332u
CHEMBL3143521 113468 0 None - 0 Rabbit 7.8 pIC50 = 7.8 Binding
Inhibition of the motilin receptor (MTL-R)Inhibition of the motilin receptor (MTL-R)
ChEMBL 607 6 6 6 2.7 CC(C)(C)c1cc(C[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H](N)Cc3ccccc3)CCCCNC(=O)CCCCCNC2=O)ccc1O 10.1021/jm010332u
10940742 122193 0 None - 0 Rabbit 5.8 pIC50 = 5.8 Binding
Inhibition of the motilin receptor (MTL-R)Inhibition of the motilin receptor (MTL-R)
ChEMBL 565 6 6 6 1.6 CC(C)(C)c1cc(C[C@@H]2NC(=O)[C@@H](NC(=O)[C@H](N)Cc3ccccc3)CCCCNC(=O)CCNC2=O)ccc1O 10.1021/jm010332u
CHEMBL3350348 122193 0 None - 0 Rabbit 5.8 pIC50 = 5.8 Binding
Inhibition of the motilin receptor (MTL-R)Inhibition of the motilin receptor (MTL-R)
ChEMBL 565 6 6 6 1.6 CC(C)(C)c1cc(C[C@@H]2NC(=O)[C@@H](NC(=O)[C@H](N)Cc3ccccc3)CCCCNC(=O)CCNC2=O)ccc1O 10.1021/jm010332u
CHEMBL524083 222379 0 None - 0 Rabbit 6.7 pIC50 = 6.7 Binding
Displacement of [125I]motilin from MTL receptor in rabbit duodenum homogenateDisplacement of [125I]motilin from MTL receptor in rabbit duodenum homogenate
ChEMBL None None None C[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)c(C(C)(C)C)c1)C(N)=O 10.1016/j.bmcl.2009.05.059
44290232 108161 0 None - 0 Rabbit 8.6 pIC50 = 8.6 Binding
In vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenate
ChEMBL 711 8 1 12 4.8 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)CC(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC 10.1016/S0960-894X(01)80583-7
CHEMBL297168 108161 0 None - 0 Rabbit 8.6 pIC50 = 8.6 Binding
In vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenate
ChEMBL 711 8 1 12 4.8 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)CC(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC 10.1016/S0960-894X(01)80583-7
11018075 107164 0 None - 0 Rabbit 8.6 pIC50 = 8.6 Binding
In vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenate
ChEMBL 739 9 1 12 5.6 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)CC(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC 10.1016/S0960-894X(01)80583-7
CHEMBL289955 107164 0 None - 0 Rabbit 8.6 pIC50 = 8.6 Binding
In vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenate
ChEMBL 739 9 1 12 5.6 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)CC(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC 10.1016/S0960-894X(01)80583-7
9809991 146300 0 None - 0 Rabbit 7.7 pIC50 = 7.7 Binding
Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor
ChEMBL 670 11 2 5 6.6 O=C(Nc1ccccc1)N(CC1=C[C@@](Cc2ccccc2)(NC(=O)C(Cl)(Cl)Cl)CC1)c1cccc(OCCN2CCOCC2)c1 10.1016/j.bmcl.2006.04.017
CHEMBL379519 146300 0 None - 0 Rabbit 7.7 pIC50 = 7.7 Binding
Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor
ChEMBL 670 11 2 5 6.6 O=C(Nc1ccccc1)N(CC1=C[C@@](Cc2ccccc2)(NC(=O)C(Cl)(Cl)Cl)CC1)c1cccc(OCCN2CCOCC2)c1 10.1016/j.bmcl.2006.04.017
10211030 84520 0 None - 0 Rabbit 7.7 pIC50 = 7.7 Binding
Inhibition of [125]I-motilin binding to rabbit motilin receptor at 1 uMInhibition of [125]I-motilin binding to rabbit motilin receptor at 1 uM
ChEMBL 610 11 1 4 7.8 CC(C)(C)C(=O)N(Cc1ccccc1)C1CCCC(CN(C(=O)Nc2ccccc2)c2cccc(OCCN3CCCC3)c2)C1 10.1016/j.bmcl.2006.04.017
CHEMBL209024 84520 0 None - 0 Rabbit 7.7 pIC50 = 7.7 Binding
Inhibition of [125]I-motilin binding to rabbit motilin receptor at 1 uMInhibition of [125]I-motilin binding to rabbit motilin receptor at 1 uM
ChEMBL 610 11 1 4 7.8 CC(C)(C)C(=O)N(Cc1ccccc1)C1CCCC(CN(C(=O)Nc2ccccc2)c2cccc(OCCN3CCCC3)c2)C1 10.1016/j.bmcl.2006.04.017
44374025 58954 0 None - 0 Rabbit 5.7 pIC50 = 5.7 Binding
Inhibition of the motilin receptor (MTL-R)Inhibition of the motilin receptor (MTL-R)
ChEMBL 565 6 6 6 1.6 CC(C)(C)c1cc(CC2NC(=O)[C@@H](NC(=O)C(N)Cc3ccccc3)CCCCNC(=O)CCNC2=O)ccc1O 10.1021/jm010332u
CHEMBL158821 58954 0 None - 0 Rabbit 5.7 pIC50 = 5.7 Binding
Inhibition of the motilin receptor (MTL-R)Inhibition of the motilin receptor (MTL-R)
ChEMBL 565 6 6 6 1.6 CC(C)(C)c1cc(CC2NC(=O)[C@@H](NC(=O)C(N)Cc3ccccc3)CCCCNC(=O)CCNC2=O)ccc1O 10.1021/jm010332u
1448 9257 34 None - 0 Human 6.7 pIC50 = 6.7 Binding
Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)
ChEMBL 715 7 4 13 2.9 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@H]([C@@]2(OC(=C(C)C2)[C@@H]([C@H]([C@]1(C)O)O)C)C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C)C 10.1016/0960-894X(95)00122-A
83954 9257 34 None - 0 Human 6.7 pIC50 = 6.7 Binding
Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)
ChEMBL 715 7 4 13 2.9 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@H]([C@@]2(OC(=C(C)C2)[C@@H]([C@H]([C@]1(C)O)O)C)C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C)C 10.1016/0960-894X(95)00122-A
CHEMBL300004 9257 34 None - 0 Human 6.7 pIC50 = 6.7 Binding
Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)
ChEMBL 715 7 4 13 2.9 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@H]([C@@]2(OC(=C(C)C2)[C@@H]([C@H]([C@]1(C)O)O)C)C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C)C 10.1016/0960-894X(95)00122-A
1448 9257 34 None - 0 Rabbit 6.7 pIC50 = 6.7 Binding
Concentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor bindingConcentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor binding
ChEMBL 715 7 4 13 2.9 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@H]([C@@]2(OC(=C(C)C2)[C@@H]([C@H]([C@]1(C)O)O)C)C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C)C 10.1016/S0960-894X(01)80359-0
83954 9257 34 None - 0 Rabbit 6.7 pIC50 = 6.7 Binding
Concentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor bindingConcentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor binding
ChEMBL 715 7 4 13 2.9 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@H]([C@@]2(OC(=C(C)C2)[C@@H]([C@H]([C@]1(C)O)O)C)C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C)C 10.1016/S0960-894X(01)80359-0
CHEMBL300004 9257 34 None - 0 Rabbit 6.7 pIC50 = 6.7 Binding
Concentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor bindingConcentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor binding
ChEMBL 715 7 4 13 2.9 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@H]([C@@]2(OC(=C(C)C2)[C@@H]([C@H]([C@]1(C)O)O)C)C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C)C 10.1016/S0960-894X(01)80359-0
44583347 194599 0 None - 1 Rabbit 7.6 pIC50 = 7.6 Binding
Displacement of [125I]motilin from MTL receptor in rabbit duodenum homogenateDisplacement of [125I]motilin from MTL receptor in rabbit duodenum homogenate
ChEMBL 496 10 4 5 2.3 CC(C)[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N(C)[C@@H](Cc1ccc(O)c(C(C)(C)C)c1)C(N)=O 10.1016/j.bmcl.2009.05.059
CHEMBL495994 194599 0 None - 1 Rabbit 7.6 pIC50 = 7.6 Binding
Displacement of [125I]motilin from MTL receptor in rabbit duodenum homogenateDisplacement of [125I]motilin from MTL receptor in rabbit duodenum homogenate
ChEMBL 496 10 4 5 2.3 CC(C)[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N(C)[C@@H](Cc1ccc(O)c(C(C)(C)C)c1)C(N)=O 10.1016/j.bmcl.2009.05.059
11081770 96234 0 None - 0 Rabbit 4.6 pIC50 = 4.6 Binding
Inhibition of the motilin receptor (MTL-R)Inhibition of the motilin receptor (MTL-R)
ChEMBL 509 6 6 6 0.3 N[C@@H](Cc1ccccc1)C(=O)N[C@H]1CCCCNC(=O)CCNC(=O)[C@H](Cc2ccc(O)cc2)NC1=O 10.1021/jm010332u
CHEMBL2371260 96234 0 None - 0 Rabbit 4.6 pIC50 = 4.6 Binding
Inhibition of the motilin receptor (MTL-R)Inhibition of the motilin receptor (MTL-R)
ChEMBL 509 6 6 6 0.3 N[C@@H](Cc1ccccc1)C(=O)N[C@H]1CCCCNC(=O)CCNC(=O)[C@H](Cc2ccc(O)cc2)NC1=O 10.1021/jm010332u
CHEMBL496390 220861 0 None - 1 Rabbit 7.6 pIC50 = 7.6 Binding
Displacement of [125I]motilin from MTL receptor in rabbit duodenum homogenateDisplacement of [125I]motilin from MTL receptor in rabbit duodenum homogenate
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)c(C(C)(C)C)c1)C(N)=O 10.1016/j.bmcl.2009.05.059
23557218 146334 0 None - 0 Rabbit 7.5 pIC50 = 7.5 Binding
Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor
ChEMBL 613 11 0 4 7.6 CC(C)(C)C(=O)N(Cc1ccccc1)C1CCCC(CN(C(=O)c2ccc(F)cc2)c2cccc(OCCN3CCCC3)c2)C1 10.1016/j.bmcl.2006.04.017
CHEMBL379665 146334 0 None - 0 Rabbit 7.5 pIC50 = 7.5 Binding
Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor
ChEMBL 613 11 0 4 7.6 CC(C)(C)C(=O)N(Cc1ccccc1)C1CCCC(CN(C(=O)c2ccc(F)cc2)c2cccc(OCCN3CCCC3)c2)C1 10.1016/j.bmcl.2006.04.017
44380970 127178 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Compound was tested for in vitro motilin receptor binding affinityCompound was tested for in vitro motilin receptor binding affinity
ChEMBL 715 8 4 13 3.0 CCC1OC(=O)C(C)C(OC2C[C@@](C)(OC)[C@@H](O)C(C)O2)C[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/0960-894X(95)00122-A
CHEMBL353526 127178 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Compound was tested for in vitro motilin receptor binding affinityCompound was tested for in vitro motilin receptor binding affinity
ChEMBL 715 8 4 13 3.0 CCC1OC(=O)C(C)C(OC2C[C@@](C)(OC)[C@@H](O)C(C)O2)C[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/0960-894X(95)00122-A
44276737 104153 0 None - 0 Rabbit 8.5 pIC50 = 8.5 Binding
Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50
ChEMBL 729 8 4 13 3.3 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/S0960-894X(01)80359-0
CHEMBL26966 104153 0 None - 0 Rabbit 8.5 pIC50 = 8.5 Binding
Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50
ChEMBL 729 8 4 13 3.3 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/S0960-894X(01)80359-0
44276737 104153 0 None - 0 Rabbit 8.5 pIC50 = 8.5 Binding
In vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenate
ChEMBL 729 8 4 13 3.3 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/S0960-894X(01)80583-7
CHEMBL26966 104153 0 None - 0 Rabbit 8.5 pIC50 = 8.5 Binding
In vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenate
ChEMBL 729 8 4 13 3.3 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/S0960-894X(01)80583-7
1448 9257 34 None - 0 Human 8.5 pIC50 = 8.5 Binding
Compound was tested for in vitro motilin receptor binding affinityCompound was tested for in vitro motilin receptor binding affinity
ChEMBL 715 7 4 13 2.9 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@H]([C@@]2(OC(=C(C)C2)[C@@H]([C@H]([C@]1(C)O)O)C)C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C)C 10.1016/0960-894X(95)00122-A
83954 9257 34 None - 0 Human 8.5 pIC50 = 8.5 Binding
Compound was tested for in vitro motilin receptor binding affinityCompound was tested for in vitro motilin receptor binding affinity
ChEMBL 715 7 4 13 2.9 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@H]([C@@]2(OC(=C(C)C2)[C@@H]([C@H]([C@]1(C)O)O)C)C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C)C 10.1016/0960-894X(95)00122-A
CHEMBL300004 9257 34 None - 0 Human 8.5 pIC50 = 8.5 Binding
Compound was tested for in vitro motilin receptor binding affinityCompound was tested for in vitro motilin receptor binding affinity
ChEMBL 715 7 4 13 2.9 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@H]([C@@]2(OC(=C(C)C2)[C@@H]([C@H]([C@]1(C)O)O)C)C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C)C 10.1016/0960-894X(95)00122-A
1448 9257 34 None - 0 Rabbit 8.5 pIC50 = 8.5 Binding
Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50
ChEMBL 715 7 4 13 2.9 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@H]([C@@]2(OC(=C(C)C2)[C@@H]([C@H]([C@]1(C)O)O)C)C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C)C 10.1016/S0960-894X(01)80359-0
83954 9257 34 None - 0 Rabbit 8.5 pIC50 = 8.5 Binding
Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50
ChEMBL 715 7 4 13 2.9 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@H]([C@@]2(OC(=C(C)C2)[C@@H]([C@H]([C@]1(C)O)O)C)C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C)C 10.1016/S0960-894X(01)80359-0
CHEMBL300004 9257 34 None - 0 Rabbit 8.5 pIC50 = 8.5 Binding
Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50
ChEMBL 715 7 4 13 2.9 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@H]([C@@]2(OC(=C(C)C2)[C@@H]([C@H]([C@]1(C)O)O)C)C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C)C 10.1016/S0960-894X(01)80359-0
44290012 174940 0 None - 0 Rabbit 8.5 pIC50 = 8.5 Binding
In vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenate
ChEMBL 725 9 1 12 5.2 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)CC(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC 10.1016/S0960-894X(01)80583-7
CHEMBL43313 174940 0 None - 0 Rabbit 8.5 pIC50 = 8.5 Binding
In vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenate
ChEMBL 725 9 1 12 5.2 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)CC(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC 10.1016/S0960-894X(01)80583-7
44276779 103646 0 None - 0 Rabbit 8.4 pIC50 = 8.4 Binding
Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50
ChEMBL 741 9 2 13 4.1 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC 10.1016/S0960-894X(01)80359-0
CHEMBL265495 103646 0 None - 0 Rabbit 8.4 pIC50 = 8.4 Binding
Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50
ChEMBL 741 9 2 13 4.1 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC 10.1016/S0960-894X(01)80359-0
44290012 174940 0 None - 0 Rabbit 8.4 pIC50 = 8.4 Binding
In vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tissue homogenate
ChEMBL 725 9 1 12 5.2 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)CC(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC 10.1016/S0960-894X(01)80583-7
CHEMBL43313 174940 0 None - 0 Rabbit 8.4 pIC50 = 8.4 Binding
In vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tissue homogenate
ChEMBL 725 9 1 12 5.2 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)CC(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC 10.1016/S0960-894X(01)80583-7
44276779 103646 0 None - 0 Rabbit 8.4 pIC50 = 8.4 Binding
In vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenate
ChEMBL 741 9 2 13 4.1 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC 10.1016/S0960-894X(01)80583-7
CHEMBL265495 103646 0 None - 0 Rabbit 8.4 pIC50 = 8.4 Binding
In vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenate
ChEMBL 741 9 2 13 4.1 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC 10.1016/S0960-894X(01)80583-7
44290232 108161 0 None - 0 Rabbit 8.4 pIC50 = 8.4 Binding
In vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tissue homogenate
ChEMBL 711 8 1 12 4.8 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)CC(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC 10.1016/S0960-894X(01)80583-7
CHEMBL297168 108161 0 None - 0 Rabbit 8.4 pIC50 = 8.4 Binding
In vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tissue homogenate
ChEMBL 711 8 1 12 4.8 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)CC(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC 10.1016/S0960-894X(01)80583-7
177964 9322 2 None - 0 Human 8.4 pIC50 = 8.4 Binding
Antagonist activity at MLNR (unknown origin)Antagonist activity at MLNR (unknown origin)
ChEMBL 755 9 2 13 4.5 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@H]([C@]2(OC(=C(C)C2)[C@@H](C(=O)[C@]1(C)OC)C)C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C(C)C)C 10.1021/jm301653f
3511 9322 2 None - 0 Human 8.4 pIC50 = 8.4 Binding
Antagonist activity at MLNR (unknown origin)Antagonist activity at MLNR (unknown origin)
ChEMBL 755 9 2 13 4.5 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@H]([C@]2(OC(=C(C)C2)[C@@H](C(=O)[C@]1(C)OC)C)C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C(C)C)C 10.1021/jm301653f
CHEMBL1778156 9322 2 None - 0 Human 8.4 pIC50 = 8.4 Binding
Antagonist activity at MLNR (unknown origin)Antagonist activity at MLNR (unknown origin)
ChEMBL 755 9 2 13 4.5 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@H]([C@]2(OC(=C(C)C2)[C@@H](C(=O)[C@]1(C)OC)C)C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C(C)C)C 10.1021/jm301653f
16040587 186163 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Antagonist activity at MLNR (unknown origin)Antagonist activity at MLNR (unknown origin)
ChEMBL 501 6 2 5 4.8 C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1 10.1021/jm301653f
CHEMBL473921 186163 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Antagonist activity at MLNR (unknown origin)Antagonist activity at MLNR (unknown origin)
ChEMBL 501 6 2 5 4.8 C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1 10.1021/jm301653f
44380970 127178 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)
ChEMBL 715 8 4 13 3.0 CCC1OC(=O)C(C)C(OC2C[C@@](C)(OC)[C@@H](O)C(C)O2)C[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/0960-894X(95)00122-A
CHEMBL353526 127178 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)
ChEMBL 715 8 4 13 3.0 CCC1OC(=O)C(C)C(OC2C[C@@](C)(OC)[C@@H](O)C(C)O2)C[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/0960-894X(95)00122-A
44276737 104153 0 None - 0 Rabbit 6.5 pIC50 = 6.5 Binding
Concentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor bindingConcentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor binding
ChEMBL 729 8 4 13 3.3 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/S0960-894X(01)80359-0
CHEMBL26966 104153 0 None - 0 Rabbit 6.5 pIC50 = 6.5 Binding
Concentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor bindingConcentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor binding
ChEMBL 729 8 4 13 3.3 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/S0960-894X(01)80359-0
44276737 104153 0 None - 0 Rabbit 6.5 pIC50 = 6.5 Binding
In vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tissue homogenate
ChEMBL 729 8 4 13 3.3 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/S0960-894X(01)80583-7
CHEMBL26966 104153 0 None - 0 Rabbit 6.5 pIC50 = 6.5 Binding
In vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tissue homogenate
ChEMBL 729 8 4 13 3.3 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/S0960-894X(01)80583-7
10897050 113464 0 None - 0 Rabbit 5.5 pIC50 = 5.5 Binding
Inhibition of the motilin receptor (MTL-R)Inhibition of the motilin receptor (MTL-R)
ChEMBL 565 6 6 6 1.6 CC(C)(C)c1cc(C[C@H]2NC(=O)[C@@H](NC(=O)[C@@H](N)Cc3ccccc3)CCCCNC(=O)CCNC2=O)ccc1O 10.1021/jm010332u
CHEMBL3143517 113464 0 None - 0 Rabbit 5.5 pIC50 = 5.5 Binding
Inhibition of the motilin receptor (MTL-R)Inhibition of the motilin receptor (MTL-R)
ChEMBL 565 6 6 6 1.6 CC(C)(C)c1cc(C[C@H]2NC(=O)[C@@H](NC(=O)[C@@H](N)Cc3ccccc3)CCCCNC(=O)CCNC2=O)ccc1O 10.1021/jm010332u
11146277 113465 0 None - 0 Rabbit 7.5 pIC50 = 7.5 Binding
Inhibition of the motilin receptor (MTL-R)Inhibition of the motilin receptor (MTL-R)
ChEMBL 579 6 6 6 2.0 CC(C)(C)c1cc(C[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H](N)Cc3ccccc3)CCCCNC(=O)CCCNC2=O)ccc1O 10.1021/jm010332u
CHEMBL3143518 113465 0 None - 0 Rabbit 7.5 pIC50 = 7.5 Binding
Inhibition of the motilin receptor (MTL-R)Inhibition of the motilin receptor (MTL-R)
ChEMBL 579 6 6 6 2.0 CC(C)(C)c1cc(C[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H](N)Cc3ccccc3)CCCCNC(=O)CCCNC2=O)ccc1O 10.1021/jm010332u
CHEMBL2371264 216806 0 None - 0 Rabbit 7.5 pIC50 = 7.5 Binding
Inhibition of the motilin receptor (MTL-R)Inhibition of the motilin receptor (MTL-R)
ChEMBL None None None CC(C)(C)c1cc(C[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H](N)Cc3ccccc3)CCCCNC(=O)CNC2=O)ccc1O 10.1021/jm010332u
44413071 85089 0 None - 0 Rabbit 7.5 pIC50 = 7.5 Binding
Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor
ChEMBL 731 12 1 7 7.3 O=C(Nc1ccccc1)N(CC1CCCC(N(Cc2cccc([N+](=O)[O-])c2)C(=O)C(Cl)(Cl)Cl)C1)c1cccc(OCCN2CCOCC2)c1 10.1016/j.bmcl.2006.04.017
CHEMBL210906 85089 0 None - 0 Rabbit 7.5 pIC50 = 7.5 Binding
Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor
ChEMBL 731 12 1 7 7.3 O=C(Nc1ccccc1)N(CC1CCCC(N(Cc2cccc([N+](=O)[O-])c2)C(=O)C(Cl)(Cl)Cl)C1)c1cccc(OCCN2CCOCC2)c1 10.1016/j.bmcl.2006.04.017
44380971 64349 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)
ChEMBL 729 8 3 13 3.5 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)OC 10.1016/0960-894X(95)00122-A
CHEMBL166642 64349 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)
ChEMBL 729 8 3 13 3.5 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)OC 10.1016/0960-894X(95)00122-A
44583348 194619 0 None - 1 Rabbit 8.4 pIC50 = 8.4 Binding
Displacement of [125I]motilin from MTL receptor in rabbit duodenum homogenateDisplacement of [125I]motilin from MTL receptor in rabbit duodenum homogenate
ChEMBL 510 10 3 5 2.6 CC(C)[C@@H](C(=O)N(C)[C@@H](Cc1ccc(O)c(C(C)(C)C)c1)C(N)=O)N(C)C(=O)[C@@H](N)Cc1ccccc1 10.1016/j.bmcl.2009.05.059
CHEMBL496190 194619 0 None - 1 Rabbit 8.4 pIC50 = 8.4 Binding
Displacement of [125I]motilin from MTL receptor in rabbit duodenum homogenateDisplacement of [125I]motilin from MTL receptor in rabbit duodenum homogenate
ChEMBL 510 10 3 5 2.6 CC(C)[C@@H](C(=O)N(C)[C@@H](Cc1ccc(O)c(C(C)(C)C)c1)C(N)=O)N(C)C(=O)[C@@H](N)Cc1ccccc1 10.1016/j.bmcl.2009.05.059
44380610 103201 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Compound was tested for in vitro motilin receptor binding affinityCompound was tested for in vitro motilin receptor binding affinity
ChEMBL 743 9 3 13 3.9 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)OC 10.1016/0960-894X(95)00122-A
CHEMBL262052 103201 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Compound was tested for in vitro motilin receptor binding affinityCompound was tested for in vitro motilin receptor binding affinity
ChEMBL 743 9 3 13 3.9 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)OC 10.1016/0960-894X(95)00122-A
11081770 96234 0 None - 0 Rabbit 4.4 pIC50 = 4.4 Binding
Inhibition of the motilin receptor (MTL-R)Inhibition of the motilin receptor (MTL-R)
ChEMBL 509 6 6 6 0.3 N[C@@H](Cc1ccccc1)C(=O)N[C@H]1CCCCNC(=O)CCNC(=O)[C@H](Cc2ccc(O)cc2)NC1=O 10.1021/jm010332u
CHEMBL2371260 96234 0 None - 0 Rabbit 4.4 pIC50 = 4.4 Binding
Inhibition of the motilin receptor (MTL-R)Inhibition of the motilin receptor (MTL-R)
ChEMBL 509 6 6 6 0.3 N[C@@H](Cc1ccccc1)C(=O)N[C@H]1CCCCNC(=O)CCNC(=O)[C@H](Cc2ccc(O)cc2)NC1=O 10.1021/jm010332u
1048 8366 76 None - 1 Human 7.4 pIC50 = 7.4 Binding
Compound was tested for in vitro motilin receptor binding affinityCompound was tested for in vitro motilin receptor binding affinity
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1016/0960-894X(95)00122-A
12560 8366 76 None - 1 Human 7.4 pIC50 = 7.4 Binding
Compound was tested for in vitro motilin receptor binding affinityCompound was tested for in vitro motilin receptor binding affinity
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1016/0960-894X(95)00122-A
1456 8366 76 None - 1 Human 7.4 pIC50 = 7.4 Binding
Compound was tested for in vitro motilin receptor binding affinityCompound was tested for in vitro motilin receptor binding affinity
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1016/0960-894X(95)00122-A
CHEMBL532 8366 76 None - 1 Human 7.4 pIC50 = 7.4 Binding
Compound was tested for in vitro motilin receptor binding affinityCompound was tested for in vitro motilin receptor binding affinity
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1016/0960-894X(95)00122-A
DB00199 8366 76 None - 1 Human 7.4 pIC50 = 7.4 Binding
Compound was tested for in vitro motilin receptor binding affinityCompound was tested for in vitro motilin receptor binding affinity
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1016/0960-894X(95)00122-A
10897911 163056 0 None - 0 Rabbit 7.4 pIC50 = 7.4 Binding
Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50
ChEMBL 733 7 5 14 1.8 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/S0960-894X(01)80359-0
CHEMBL406517 163056 0 None - 0 Rabbit 7.4 pIC50 = 7.4 Binding
Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50
ChEMBL 733 7 5 14 1.8 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/S0960-894X(01)80359-0
CHEMBL496389 220860 0 None - 1 Rabbit 7.3 pIC50 = 7.3 Binding
Displacement of [125I]motilin from MTL receptor in rabbit duodenum homogenateDisplacement of [125I]motilin from MTL receptor in rabbit duodenum homogenate
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)c(C(C)(C)C)c1)C(N)=O 10.1016/j.bmcl.2009.05.059
11135894 113469 0 None - 0 Rabbit 6.3 pIC50 = 6.3 Binding
Inhibition of the motilin receptor (MTL-R)Inhibition of the motilin receptor (MTL-R)
ChEMBL 621 6 6 6 2.9 CC(C)(C)c1cc(C[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H](N)Cc3ccccc3)CCCCNC(=O)CCNC2=O)cc(C(C)(C)C)c1O 10.1021/jm010332u
CHEMBL3143523 113469 0 None - 0 Rabbit 6.3 pIC50 = 6.3 Binding
Inhibition of the motilin receptor (MTL-R)Inhibition of the motilin receptor (MTL-R)
ChEMBL 621 6 6 6 2.9 CC(C)(C)c1cc(C[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H](N)Cc3ccccc3)CCCCNC(=O)CCNC2=O)cc(C(C)(C)C)c1O 10.1021/jm010332u
10995344 113466 0 None - 0 Rabbit 6.3 pIC50 = 6.3 Binding
Inhibition of the motilin receptor (MTL-R)Inhibition of the motilin receptor (MTL-R)
ChEMBL 565 9 5 6 1.8 CCC(C)Oc1ccc(C[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H](N)Cc3ccccc3)CCCCNC(=O)CCNC2=O)cc1 10.1021/jm010332u
CHEMBL3143519 113466 0 None - 0 Rabbit 6.3 pIC50 = 6.3 Binding
Inhibition of the motilin receptor (MTL-R)Inhibition of the motilin receptor (MTL-R)
ChEMBL 565 9 5 6 1.8 CCC(C)Oc1ccc(C[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H](N)Cc3ccccc3)CCCCNC(=O)CCNC2=O)cc1 10.1021/jm010332u
44412861 84649 0 None - 0 Rabbit 7.2 pIC50 = 7.2 Binding
Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor
ChEMBL 673 11 0 4 7.9 O=C(c1ccc(F)cc1)N(CC1CCCC(N(Cc2ccccc2)C(=O)C(Cl)(Cl)Cl)C1)c1cccc(OCCN2CCCC2)c1 10.1016/j.bmcl.2006.04.017
CHEMBL209333 84649 0 None - 0 Rabbit 7.2 pIC50 = 7.2 Binding
Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor
ChEMBL 673 11 0 4 7.9 O=C(c1ccc(F)cc1)N(CC1CCCC(N(Cc2ccccc2)C(=O)C(Cl)(Cl)Cl)C1)c1cccc(OCCN2CCCC2)c1 10.1016/j.bmcl.2006.04.017
44412878 147860 0 None - 0 Rabbit 7.2 pIC50 = 7.2 Binding
Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor
ChEMBL 707 11 0 4 8.6 O=C(c1ccc(F)cc1)N(CC1CCCC(N(Cc2cccc(Cl)c2)C(=O)C(Cl)(Cl)Cl)C1)c1cccc(OCCN2CCCC2)c1 10.1016/j.bmcl.2006.04.017
CHEMBL382612 147860 0 None - 0 Rabbit 7.2 pIC50 = 7.2 Binding
Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor
ChEMBL 707 11 0 4 8.6 O=C(c1ccc(F)cc1)N(CC1CCCC(N(Cc2cccc(Cl)c2)C(=O)C(Cl)(Cl)Cl)C1)c1cccc(OCCN2CCCC2)c1 10.1016/j.bmcl.2006.04.017
11146277 113465 0 None - 0 Rabbit 7.2 pIC50 = 7.2 Binding
Inhibition of the motilin receptor (MTL-R)Inhibition of the motilin receptor (MTL-R)
ChEMBL 579 6 6 6 2.0 CC(C)(C)c1cc(C[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H](N)Cc3ccccc3)CCCCNC(=O)CCCNC2=O)ccc1O 10.1021/jm010332u
CHEMBL3143518 113465 0 None - 0 Rabbit 7.2 pIC50 = 7.2 Binding
Inhibition of the motilin receptor (MTL-R)Inhibition of the motilin receptor (MTL-R)
ChEMBL 579 6 6 6 2.0 CC(C)(C)c1cc(C[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H](N)Cc3ccccc3)CCCCNC(=O)CCCNC2=O)ccc1O 10.1021/jm010332u
CHEMBL502792 220937 0 None - 1 Rabbit 8.2 pIC50 = 8.2 Binding
Displacement of [125I]motilin from MTL receptor in rabbit duodenum homogenateDisplacement of [125I]motilin from MTL receptor in rabbit duodenum homogenate
ChEMBL None None None CC(C)(C)c1cc(C[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)Cc2ccccc2)C(N)=O)ccc1O 10.1016/j.bmcl.2009.05.059
44276778 104982 0 None - 0 Rabbit 8.2 pIC50 = 8.2 Binding
Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50
ChEMBL 755 9 2 13 4.5 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC 10.1016/S0960-894X(01)80359-0
CHEMBL27424 104982 0 None - 0 Rabbit 8.2 pIC50 = 8.2 Binding
Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50
ChEMBL 755 9 2 13 4.5 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC 10.1016/S0960-894X(01)80359-0
44276778 104982 0 None - 0 Rabbit 8.2 pIC50 = 8.2 Binding
In vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenate
ChEMBL 755 9 2 13 4.5 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC 10.1016/S0960-894X(01)80583-7
CHEMBL27424 104982 0 None - 0 Rabbit 8.2 pIC50 = 8.2 Binding
In vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenate
ChEMBL 755 9 2 13 4.5 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC 10.1016/S0960-894X(01)80583-7
44276779 103646 0 None - 0 Rabbit 8.2 pIC50 = 8.2 Binding
Concentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor bindingConcentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor binding
ChEMBL 741 9 2 13 4.1 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC 10.1016/S0960-894X(01)80359-0
CHEMBL265495 103646 0 None - 0 Rabbit 8.2 pIC50 = 8.2 Binding
Concentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor bindingConcentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor binding
ChEMBL 741 9 2 13 4.1 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC 10.1016/S0960-894X(01)80359-0
44276779 103646 0 None - 0 Rabbit 8.2 pIC50 = 8.2 Binding
In vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tissue homogenate
ChEMBL 741 9 2 13 4.1 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC 10.1016/S0960-894X(01)80583-7
CHEMBL265495 103646 0 None - 0 Rabbit 8.2 pIC50 = 8.2 Binding
In vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tissue homogenate
ChEMBL 741 9 2 13 4.1 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC 10.1016/S0960-894X(01)80583-7
44380651 126910 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Compound was tested for in vitro motilin receptor binding affinityCompound was tested for in vitro motilin receptor binding affinity
ChEMBL 757 9 3 13 4.3 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)OC 10.1016/0960-894X(95)00122-A
CHEMBL351216 126910 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Compound was tested for in vitro motilin receptor binding affinityCompound was tested for in vitro motilin receptor binding affinity
ChEMBL 757 9 3 13 4.3 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)OC 10.1016/0960-894X(95)00122-A
23557214 147861 0 None - 0 Rabbit 7.2 pIC50 = 7.2 Binding
Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor
ChEMBL 721 11 0 4 8.9 O=C(c1ccc(F)cc1)N(CC1CCCC(N(Cc2cccc(Cl)c2)C(=O)C(Cl)(Cl)Cl)C1)c1cccc(OCCN2CCCCC2)c1 10.1016/j.bmcl.2006.04.017
CHEMBL382613 147861 0 None - 0 Rabbit 7.2 pIC50 = 7.2 Binding
Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor
ChEMBL 721 11 0 4 8.9 O=C(c1ccc(F)cc1)N(CC1CCCC(N(Cc2cccc(Cl)c2)C(=O)C(Cl)(Cl)Cl)C1)c1cccc(OCCN2CCCCC2)c1 10.1016/j.bmcl.2006.04.017
11767227 113468 0 None - 0 Rabbit 7.2 pIC50 = 7.2 Binding
Inhibition of the motilin receptor (MTL-R)Inhibition of the motilin receptor (MTL-R)
ChEMBL 607 6 6 6 2.7 CC(C)(C)c1cc(C[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H](N)Cc3ccccc3)CCCCNC(=O)CCCCCNC2=O)ccc1O 10.1021/jm010332u
CHEMBL3143521 113468 0 None - 0 Rabbit 7.2 pIC50 = 7.2 Binding
Inhibition of the motilin receptor (MTL-R)Inhibition of the motilin receptor (MTL-R)
ChEMBL 607 6 6 6 2.7 CC(C)(C)c1cc(C[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H](N)Cc3ccccc3)CCCCNC(=O)CCCCCNC2=O)ccc1O 10.1021/jm010332u
44412941 147108 0 None - 0 Rabbit 6.2 pIC50 = 6.2 Binding
Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor
ChEMBL 710 13 1 6 8.0 COc1cccc(C(=O)N(Cc2cccc(Cl)c2)C2CCCC(CN(C(=O)Nc3ccccc3)c3cccc(OCCN4CCOCC4)c3)C2)c1 10.1016/j.bmcl.2006.04.017
CHEMBL380678 147108 0 None - 0 Rabbit 6.2 pIC50 = 6.2 Binding
Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor
ChEMBL 710 13 1 6 8.0 COc1cccc(C(=O)N(Cc2cccc(Cl)c2)C2CCCC(CN(C(=O)Nc3ccccc3)c3cccc(OCCN4CCOCC4)c3)C2)c1 10.1016/j.bmcl.2006.04.017
44413072 85091 0 None - 0 Rabbit 6.2 pIC50 = 6.2 Binding
Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor
ChEMBL 636 12 1 6 6.9 O=C(Nc1ccccc1)N(CC1CCCC(N(Cc2ccccc2)C(=O)c2ccco2)C1)c1cccc(OCCN2CCOCC2)c1 10.1016/j.bmcl.2006.04.017
CHEMBL210923 85091 0 None - 0 Rabbit 6.2 pIC50 = 6.2 Binding
Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor
ChEMBL 636 12 1 6 6.9 O=C(Nc1ccccc1)N(CC1CCCC(N(Cc2ccccc2)C(=O)c2ccco2)C1)c1cccc(OCCN2CCOCC2)c1 10.1016/j.bmcl.2006.04.017
CHEMBL2371264 216806 0 None - 0 Rabbit 8.2 pIC50 = 8.2 Binding
Inhibition of the motilin receptor (MTL-R)Inhibition of the motilin receptor (MTL-R)
ChEMBL None None None CC(C)(C)c1cc(C[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H](N)Cc3ccccc3)CCCCNC(=O)CNC2=O)ccc1O 10.1021/jm010332u
44380971 64349 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Compound was tested for in vitro motilin receptor binding affinityCompound was tested for in vitro motilin receptor binding affinity
ChEMBL 729 8 3 13 3.5 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)OC 10.1016/0960-894X(95)00122-A
CHEMBL166642 64349 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Compound was tested for in vitro motilin receptor binding affinityCompound was tested for in vitro motilin receptor binding affinity
ChEMBL 729 8 3 13 3.5 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)OC 10.1016/0960-894X(95)00122-A
44276778 104982 0 None - 0 Rabbit 8.1 pIC50 = 8.1 Binding
Concentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor bindingConcentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor binding
ChEMBL 755 9 2 13 4.5 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC 10.1016/S0960-894X(01)80359-0
CHEMBL27424 104982 0 None - 0 Rabbit 8.1 pIC50 = 8.1 Binding
Concentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor bindingConcentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor binding
ChEMBL 755 9 2 13 4.5 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC 10.1016/S0960-894X(01)80359-0
44276778 104982 0 None - 0 Rabbit 8.1 pIC50 = 8.1 Binding
In vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tissue homogenate
ChEMBL 755 9 2 13 4.5 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC 10.1016/S0960-894X(01)80583-7
CHEMBL27424 104982 0 None - 0 Rabbit 8.1 pIC50 = 8.1 Binding
In vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tissue homogenate
ChEMBL 755 9 2 13 4.5 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC 10.1016/S0960-894X(01)80583-7
1048 8366 76 None - 1 Human 7.2 pIC50 = 7.2 Binding
Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1016/0960-894X(95)00122-A
12560 8366 76 None - 1 Human 7.2 pIC50 = 7.2 Binding
Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1016/0960-894X(95)00122-A
1456 8366 76 None - 1 Human 7.2 pIC50 = 7.2 Binding
Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1016/0960-894X(95)00122-A
CHEMBL532 8366 76 None - 1 Human 7.2 pIC50 = 7.2 Binding
Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1016/0960-894X(95)00122-A
DB00199 8366 76 None - 1 Human 7.2 pIC50 = 7.2 Binding
Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1016/0960-894X(95)00122-A
10897911 163056 0 None - 0 Rabbit 7.2 pIC50 = 7.2 Binding
Concentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor bindingConcentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor binding
ChEMBL 733 7 5 14 1.8 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/S0960-894X(01)80359-0
CHEMBL406517 163056 0 None - 0 Rabbit 7.2 pIC50 = 7.2 Binding
Concentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor bindingConcentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor binding
ChEMBL 733 7 5 14 1.8 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O 10.1016/S0960-894X(01)80359-0
12016400 175739 0 None - 0 Rabbit 7.1 pIC50 = 7.1 Binding
Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor
ChEMBL 613 11 0 4 7.6 CC(C)(C)C(=O)N(Cc1ccccc1)[C@H]1CCC[C@@H](CN(C(=O)c2ccc(F)cc2)c2cccc(OCCN3CCCC3)c2)C1 10.1016/j.bmcl.2006.04.017
CHEMBL438962 175739 0 None - 0 Rabbit 7.1 pIC50 = 7.1 Binding
Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor
ChEMBL 613 11 0 4 7.6 CC(C)(C)C(=O)N(Cc1ccccc1)[C@H]1CCC[C@@H](CN(C(=O)c2ccc(F)cc2)c2cccc(OCCN3CCCC3)c2)C1 10.1016/j.bmcl.2006.04.017
44412951 84945 0 None - 0 Rabbit 6.1 pIC50 = 6.1 Binding
Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor
ChEMBL 674 14 1 5 7.7 O=C(Nc1ccccc1)N(CC1CCCC(N(Cc2ccccc2)C(=O)CCc2ccccc2)C1)c1cccc(OCCN2CCOCC2)c1 10.1016/j.bmcl.2006.04.017
CHEMBL210447 84945 0 None - 0 Rabbit 6.1 pIC50 = 6.1 Binding
Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor
ChEMBL 674 14 1 5 7.7 O=C(Nc1ccccc1)N(CC1CCCC(N(Cc2ccccc2)C(=O)CCc2ccccc2)C1)c1cccc(OCCN2CCOCC2)c1 10.1016/j.bmcl.2006.04.017
10875453 113467 0 None - 0 Rabbit 5.1 pIC50 = 5.1 Binding
Inhibition of the motilin receptor (MTL-R)Inhibition of the motilin receptor (MTL-R)
ChEMBL 565 7 5 6 1.8 CC(C)(C)Oc1ccc(C[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H](N)Cc3ccccc3)CCCCNC(=O)CCNC2=O)cc1 10.1021/jm010332u
CHEMBL3143520 113467 0 None - 0 Rabbit 5.1 pIC50 = 5.1 Binding
Inhibition of the motilin receptor (MTL-R)Inhibition of the motilin receptor (MTL-R)
ChEMBL 565 7 5 6 1.8 CC(C)(C)Oc1ccc(C[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H](N)Cc3ccccc3)CCCCNC(=O)CCNC2=O)cc1 10.1021/jm010332u
44412982 65834 0 None - 0 Rabbit 6.1 pIC50 = 6.1 Binding
Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor
ChEMBL 644 11 1 5 7.2 CC(C)(C)C(=O)N(Cc1ccccc1)C1CCCC(CN(C(=O)Nc2ccc(F)cc2)c2cccc(OCCN3CCOCC3)c2)C1 10.1016/j.bmcl.2006.04.017
CHEMBL169509 65834 0 None - 0 Rabbit 6.1 pIC50 = 6.1 Binding
Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor
ChEMBL 644 11 1 5 7.2 CC(C)(C)C(=O)N(Cc1ccccc1)C1CCCC(CN(C(=O)Nc2ccc(F)cc2)c2cccc(OCCN3CCOCC3)c2)C1 10.1016/j.bmcl.2006.04.017
44380610 103201 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)
ChEMBL 743 9 3 13 3.9 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)OC 10.1016/0960-894X(95)00122-A
CHEMBL262052 103201 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)
ChEMBL 743 9 3 13 3.9 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)OC 10.1016/0960-894X(95)00122-A
44276817 104978 0 None - 0 Rabbit 8.1 pIC50 = 8.1 Binding
Concentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor bindingConcentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor binding
ChEMBL 727 8 2 13 3.8 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC 10.1016/S0960-894X(01)80359-0
CHEMBL27419 104978 0 None - 0 Rabbit 8.1 pIC50 = 8.1 Binding
Concentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor bindingConcentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor binding
ChEMBL 727 8 2 13 3.8 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC 10.1016/S0960-894X(01)80359-0
44276817 104978 0 None - 0 Rabbit 8.1 pIC50 = 8.1 Binding
In vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tissue homogenate
ChEMBL 727 8 2 13 3.8 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC 10.1016/S0960-894X(01)80583-7
CHEMBL27419 104978 0 None - 0 Rabbit 8.1 pIC50 = 8.1 Binding
In vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tissue homogenate
ChEMBL 727 8 2 13 3.8 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC 10.1016/S0960-894X(01)80583-7
44276817 104978 0 None - 0 Rabbit 8.0 pIC50 = 8.0 Binding
Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50
ChEMBL 727 8 2 13 3.8 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC 10.1016/S0960-894X(01)80359-0
CHEMBL27419 104978 0 None - 0 Rabbit 8.0 pIC50 = 8.0 Binding
Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50
ChEMBL 727 8 2 13 3.8 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC 10.1016/S0960-894X(01)80359-0
44276817 104978 0 None - 0 Rabbit 8.0 pIC50 = 8.0 Binding
In vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenate
ChEMBL 727 8 2 13 3.8 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC 10.1016/S0960-894X(01)80583-7
CHEMBL27419 104978 0 None - 0 Rabbit 8.0 pIC50 = 8.0 Binding
In vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenate
ChEMBL 727 8 2 13 3.8 CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC 10.1016/S0960-894X(01)80583-7
44412977 86589 0 None - 0 Rabbit 6.0 pIC50 = 6.0 Binding
Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor
ChEMBL 686 11 1 5 7.4 O=C(Nc1ccccc1)N(CC1CCCC(N(Cc2ccccc2)C(=O)C(Cl)(Cl)Cl)C1)c1cccc(OCCN2CCOCC2)c1 10.1016/j.bmcl.2006.04.017
CHEMBL212044 86589 0 None - 0 Rabbit 6.0 pIC50 = 6.0 Binding
Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor
ChEMBL 686 11 1 5 7.4 O=C(Nc1ccccc1)N(CC1CCCC(N(Cc2ccccc2)C(=O)C(Cl)(Cl)Cl)C1)c1cccc(OCCN2CCOCC2)c1 10.1016/j.bmcl.2006.04.017
CHEMBL2372767 217064 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccccc1)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)O)[C@@H](C)O 10.1021/jm0606600
10010118 108212 0 None - 1 Human 9.2 pKi = 9.2 Binding
In vitro binding affinity towards human motilin receptorIn vitro binding affinity towards human motilin receptor
ChEMBL 723 13 4 11 1.7 NC(=O)[C@H](CCc1ccccc1)NC(=O)[C@H](CCc1ccccc1)NC(=O)C1CCC2(CCNCC2)n2c(=O)n(Cc3ccc4c(c3)OCO4)c(=O)n21 10.1021/jm0304865
CHEMBL297494 108212 0 None - 1 Human 9.2 pKi = 9.2 Binding
In vitro binding affinity towards human motilin receptorIn vitro binding affinity towards human motilin receptor
ChEMBL 723 13 4 11 1.7 NC(=O)[C@H](CCc1ccccc1)NC(=O)[C@H](CCc1ccccc1)NC(=O)C1CCC2(CCNCC2)n2c(=O)n(Cc3ccc4c(c3)OCO4)c(=O)n21 10.1021/jm0304865
10010118 108212 0 None - 1 Human 9.0 pKi = 9 Binding
In vitro binding affinity towards human motilin receptorIn vitro binding affinity towards human motilin receptor
ChEMBL 723 13 4 11 1.7 NC(=O)[C@H](CCc1ccccc1)NC(=O)[C@H](CCc1ccccc1)NC(=O)C1CCC2(CCNCC2)n2c(=O)n(Cc3ccc4c(c3)OCO4)c(=O)n21 10.1021/jm0304865
CHEMBL297494 108212 0 None - 1 Human 9.0 pKi = 9 Binding
In vitro binding affinity towards human motilin receptorIn vitro binding affinity towards human motilin receptor
ChEMBL 723 13 4 11 1.7 NC(=O)[C@H](CCc1ccccc1)NC(=O)[C@H](CCc1ccccc1)NC(=O)C1CCC2(CCNCC2)n2c(=O)n(Cc3ccc4c(c3)OCO4)c(=O)n21 10.1021/jm0304865
25115428 167542 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 610 5 6 7 1.0 CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(Cl)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CN/C(N)=N/C#N)NC1=O 10.1016/j.bmcl.2007.05.043
CHEMBL411408 167542 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 610 5 6 7 1.0 CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(Cl)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CN/C(N)=N/C#N)NC1=O 10.1016/j.bmcl.2007.05.043
11444593 179505 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 578 5 4 6 4.0 CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2csc3ccccc23)NCCOc2ccccc2CCCNC1=O 10.1021/jm0606600
CHEMBL450634 179505 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 578 5 4 6 4.0 CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2csc3ccccc23)NCCOc2ccccc2CCCNC1=O 10.1021/jm0606600
44432981 94748 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 595 5 4 7 2.8 CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(F)c2)NCCOc2ccccc2CCCNC(=O)[C@H](Cc2cscn2)NC1=O 10.1016/j.bmcl.2007.05.043
CHEMBL234191 94748 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 595 5 4 7 2.8 CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(F)c2)NCCOc2ccccc2CCCNC(=O)[C@H](Cc2cscn2)NC1=O 10.1016/j.bmcl.2007.05.043
11995356 87328 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 488 5 5 5 2.8 CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCCCCCCCNC1=O 10.1021/jm0606600
CHEMBL214869 87328 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 488 5 5 5 2.8 CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCCCCCCCNC1=O 10.1021/jm0606600
11994554 87347 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 536 5 5 6 2.5 CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC1=O 10.1021/jm0606600
CHEMBL214935 87347 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 536 5 5 6 2.5 CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC1=O 10.1021/jm0606600
11994554 87347 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 536 5 5 6 2.5 CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC1=O 10.1016/j.bmcl.2007.05.043
CHEMBL214935 87347 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 536 5 5 6 2.5 CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC1=O 10.1016/j.bmcl.2007.05.043
11994677 148677 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 508 3 5 6 1.8 CC(C)[C@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC(=O)[C@H](C)NC1=O 10.1021/jm0606600
CHEMBL386854 148677 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 508 3 5 6 1.8 CC(C)[C@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC(=O)[C@H](C)NC1=O 10.1021/jm0606600
11995358 87375 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 536 6 4 5 3.1 CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](CCc2ccccc2)NCCOc2ccccc2CCCNC1=O 10.1021/jm0606600
CHEMBL215043 87375 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 536 6 4 5 3.1 CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](CCc2ccccc2)NCCOc2ccccc2CCCNC1=O 10.1021/jm0606600
44432973 105088 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 577 4 5 6 1.9 CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(C(F)(F)F)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CN)NC1=O 10.1016/j.bmcl.2007.05.043
CHEMBL274876 105088 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 577 4 5 6 1.9 CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(C(F)(F)F)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CN)NC1=O 10.1016/j.bmcl.2007.05.043
11995155 148686 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 584 6 5 6 3.1 CCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC1=O 10.1021/jm0606600
CHEMBL386906 148686 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 584 6 5 6 3.1 CCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC1=O 10.1021/jm0606600
11410548 94340 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 571 5 4 6 2.2 CC(C)[C@H]1NC(=O)[C@@H](Cc2ccc(Cl)cc2)NCCOc2ccccc2CCCNC(=O)[C@H](CN(C)C)NC1=O 10.1016/j.bmcl.2007.05.043
CHEMBL233561 94340 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 571 5 4 6 2.2 CC(C)[C@H]1NC(=O)[C@@H](Cc2ccc(Cl)cc2)NCCOc2ccccc2CCCNC(=O)[C@H](CN(C)C)NC1=O 10.1016/j.bmcl.2007.05.043
25115652 104061 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 643 5 4 8 2.6 Cc1cnnn1C[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2cccc(C(F)(F)F)c2)NCCOc2ccccc2CCCNC1=O 10.1016/j.bmcl.2007.05.043
CHEMBL269007 104061 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 643 5 4 8 2.6 Cc1cnnn1C[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2cccc(C(F)(F)F)c2)NCCOc2ccccc2CCCNC1=O 10.1016/j.bmcl.2007.05.043
44432969 154381 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 525 4 6 7 0.6 CC(C)[C@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2CCCNC(=O)[C@H](CN)NC1=O 10.1016/j.bmcl.2007.05.043
CHEMBL393112 154381 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 525 4 6 7 0.6 CC(C)[C@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2CCCNC(=O)[C@H](CN)NC1=O 10.1016/j.bmcl.2007.05.043
25114977 153787 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 594 5 4 7 2.5 CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(Cl)c2)NCCOc2ccccc2CCCNC(=O)[C@H](Cn2cccn2)NC1=O 10.1016/j.bmcl.2007.05.043
CHEMBL392657 153787 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 594 5 4 7 2.5 CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(Cl)c2)NCCOc2ccccc2CCCNC(=O)[C@H](Cn2cccn2)NC1=O 10.1016/j.bmcl.2007.05.043
11994680 175544 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 584 5 5 6 3.0 CC(C)[C@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm0606600
CHEMBL437326 175544 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 584 5 5 6 3.0 CC(C)[C@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm0606600
11995359 175745 0 None - 1 Human 5.7 pKi = 5.7 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 539 5 4 7 2.9 CCC[C@@H]1OC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2CCCNC1=O 10.1021/jm0606600
CHEMBL438998 175745 0 None - 1 Human 5.7 pKi = 5.7 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 539 5 4 7 2.9 CCC[C@@H]1OC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2CCCNC1=O 10.1021/jm0606600
44467360 131313 0 None -3 2 Human 4.7 pKi = 4.7 Binding
Inhibition of human motilin receptorInhibition of human motilin receptor
ChEMBL 420 3 2 6 1.5 COc1nc(N2C[C@H]3C(=O)N(C)C(=N)N[C@@]3(c3ccc(F)cc3F)C2)nc(C)c1F 10.1021/acs.jmedchem.5b01995
CHEMBL3640290 131313 0 None -3 2 Human 4.7 pKi = 4.7 Binding
Inhibition of human motilin receptorInhibition of human motilin receptor
ChEMBL 420 3 2 6 1.5 COc1nc(N2C[C@H]3C(=O)N(C)C(=N)N[C@@]3(c3ccc(F)cc3F)C2)nc(C)c1F 10.1021/acs.jmedchem.5b01995
11994928 148647 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 539 5 4 7 2.9 CCC[C@@H]1NC(=O)[C@@H](C(C)C)OC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2CCCNC1=O 10.1021/jm0606600
CHEMBL386626 148647 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 539 5 4 7 2.9 CCC[C@@H]1NC(=O)[C@@H](C(C)C)OC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2CCCNC1=O 10.1021/jm0606600
44432971 93813 0 None - 1 Human 5.7 pKi = 5.7 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 567 5 6 7 0.8 CC(=O)NC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2CCCNC1=O 10.1016/j.bmcl.2007.05.043
CHEMBL232551 93813 0 None - 1 Human 5.7 pKi = 5.7 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 567 5 6 7 0.8 CC(=O)NC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2CCCNC1=O 10.1016/j.bmcl.2007.05.043
11995153 148413 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 508 4 5 6 1.9 CCC[C@@H]1NC(=O)[C@@H](C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC1=O 10.1021/jm0606600
CHEMBL385293 148413 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 508 4 5 6 1.9 CCC[C@@H]1NC(=O)[C@@H](C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC1=O 10.1021/jm0606600
11181688 108112 0 None - 1 Human 8.7 pKi = 8.7 Binding
In vitro binding affinity towards human motilin receptorIn vitro binding affinity towards human motilin receptor
ChEMBL 721 13 4 11 1.5 NC(=O)[C@H](CCc1ccccc1)NC(=O)[C@H](CCc1ccccc1)NC(=O)C1C=CC2(CCNCC2)n2c(=O)n(Cc3ccc4c(c3)OCO4)c(=O)n21 10.1021/jm0304865
CHEMBL296748 108112 0 None - 1 Human 8.7 pKi = 8.7 Binding
In vitro binding affinity towards human motilin receptorIn vitro binding affinity towards human motilin receptor
ChEMBL 721 13 4 11 1.5 NC(=O)[C@H](CCc1ccccc1)NC(=O)[C@H](CCc1ccccc1)NC(=O)C1C=CC2(CCNCC2)n2c(=O)n(Cc3ccc4c(c3)OCO4)c(=O)n21 10.1021/jm0304865
71720372 95828 0 None - 1 Human 8.6 pKi = 8.6 Binding
Agonist activity at MLNR (unknown origin)Agonist activity at MLNR (unknown origin)
ChEMBL 570 13 4 6 3.3 CCNC(=O)[C@H](Cc1ccc(O)c(C(C)(C)C)c1)C(N)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](Cc1ccc(F)cc1)NC 10.1021/jm301653f
CHEMBL2313632 95828 0 None - 1 Human 8.6 pKi = 8.6 Binding
Agonist activity at MLNR (unknown origin)Agonist activity at MLNR (unknown origin)
ChEMBL 570 13 4 6 3.3 CCNC(=O)[C@H](Cc1ccc(O)c(C(C)(C)C)c1)C(N)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](Cc1ccc(F)cc1)NC 10.1021/jm301653f
CHEMBL2364821 95828 0 None - 1 Human 8.6 pKi = 8.6 Binding
Agonist activity at MLNR (unknown origin)Agonist activity at MLNR (unknown origin)
ChEMBL 570 13 4 6 3.3 CCNC(=O)[C@H](Cc1ccc(O)c(C(C)(C)C)c1)C(N)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](Cc1ccc(F)cc1)NC 10.1021/jm301653f
44292517 108308 0 None - 1 Human 8.6 pKi = 8.6 Binding
In vitro binding affinity towards human motilin receptorIn vitro binding affinity towards human motilin receptor
ChEMBL 723 13 4 11 1.7 NC(=O)[C@@H](CCc1ccccc1)NC(=O)[C@@H](CCc1ccccc1)NC(=O)C1CCC2(CCNCC2)n2c(=O)n(Cc3ccc4c(c3)OCO4)c(=O)n21 10.1021/jm0304865
CHEMBL298224 108308 0 None - 1 Human 8.6 pKi = 8.6 Binding
In vitro binding affinity towards human motilin receptorIn vitro binding affinity towards human motilin receptor
ChEMBL 723 13 4 11 1.7 NC(=O)[C@@H](CCc1ccccc1)NC(=O)[C@@H](CCc1ccccc1)NC(=O)C1CCC2(CCNCC2)n2c(=O)n(Cc3ccc4c(c3)OCO4)c(=O)n21 10.1021/jm0304865
25115429 93475 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 655 6 5 8 2.9 CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(C(F)(F)F)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CNc2ncccn2)NC1=O 10.1016/j.bmcl.2007.05.043
CHEMBL231744 93475 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 655 6 5 8 2.9 CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(C(F)(F)F)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CNc2ncccn2)NC1=O 10.1016/j.bmcl.2007.05.043
25115653 153785 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 644 5 4 9 2.0 Cc1nnnn1C[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2cccc(C(F)(F)F)c2)NCCOc2ccccc2CCCNC1=O 10.1016/j.bmcl.2007.05.043
CHEMBL392656 153785 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 644 5 4 9 2.0 Cc1nnnn1C[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2cccc(C(F)(F)F)c2)NCCOc2ccccc2CCCNC1=O 10.1016/j.bmcl.2007.05.043
11250008 87188 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 566 5 4 6 3.0 CC(C)C[C@H]1C(=O)NCCCc2ccccc2OCCN[C@H](Cc2ccc(O)cc2)C(=O)N[C@H](C(C)C)C(=O)N1C 10.1021/jm0606600
CHEMBL214570 87188 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 566 5 4 6 3.0 CC(C)C[C@H]1C(=O)NCCCc2ccccc2OCCN[C@H](Cc2ccc(O)cc2)C(=O)N[C@H](C(C)C)C(=O)N1C 10.1021/jm0606600
25115654 166783 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 657 5 4 8 2.9 Cc1nnn(C[C@@H]2NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc3cccc(C(F)(F)F)c3)NCCOc3ccccc3CCCNC2=O)c1C 10.1016/j.bmcl.2007.05.043
CHEMBL410786 166783 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 657 5 4 8 2.9 Cc1nnn(C[C@@H]2NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc3cccc(C(F)(F)F)c3)NCCOc3ccccc3CCCNC2=O)c1C 10.1016/j.bmcl.2007.05.043
11995042 148665 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 553 5 6 7 2.0 CCC[C@@H]1NC(=O)[C@@H](C(C)C)NNC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2CCCNC1=O 10.1021/jm0606600
CHEMBL386735 148665 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 553 5 6 7 2.0 CCC[C@@H]1NC(=O)[C@@H](C(C)C)NNC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2CCCNC1=O 10.1021/jm0606600
11192254 148487 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 561 5 5 5 3.2 CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NCCOc2ccccc2CCCNC1=O 10.1021/jm0606600
CHEMBL385673 148487 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 561 5 5 5 3.2 CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NCCOc2ccccc2CCCNC1=O 10.1021/jm0606600
11995157 176103 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 552 5 6 7 1.2 CC(C)[C@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC(=O)[C@H](CC(=O)O)NC1=O 10.1021/jm0606600
CHEMBL441697 176103 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 552 5 6 7 1.2 CC(C)[C@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC(=O)[C@H](CC(=O)O)NC1=O 10.1021/jm0606600
11995157 176103 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 552 5 6 7 1.2 CC(C)[C@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC(=O)[C@H](CC(=O)O)NC1=O 10.1016/j.bmcl.2007.05.043
CHEMBL441697 176103 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 552 5 6 7 1.2 CC(C)[C@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC(=O)[C@H](CC(=O)O)NC1=O 10.1016/j.bmcl.2007.05.043
25115200 95020 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 584 6 6 6 2.3 CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(Cl)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CCC(=N)N)NC1=O 10.1016/j.bmcl.2007.05.043
CHEMBL234810 95020 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 584 6 6 6 2.3 CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(Cl)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CCC(=N)N)NC1=O 10.1016/j.bmcl.2007.05.043
44432976 161643 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 571 5 4 6 2.2 CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(Cl)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CN(C)C)NC1=O 10.1016/j.bmcl.2007.05.043
CHEMBL400635 161643 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 571 5 4 6 2.2 CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(Cl)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CN(C)C)NC1=O 10.1016/j.bmcl.2007.05.043
11995454 148552 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 552 5 4 6 2.8 CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)N(C)CCOc2ccccc2CCCNC1=O 10.1021/jm0606600
CHEMBL386086 148552 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 552 5 4 6 2.8 CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)N(C)CCOc2ccccc2CCCNC1=O 10.1021/jm0606600
CHEMBL2372767 217064 0 None - 1 Human 8.5 pKi = 8.5 Binding
In vitro binding affinity towards human motilin receptorIn vitro binding affinity towards human motilin receptor
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccccc1)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)O)[C@@H](C)O 10.1021/jm0304865
53322109 63043 0 None - 1 Human 8.5 pKi = 8.5 Binding
In vitro binding affinity towards human motilin receptorIn vitro binding affinity towards human motilin receptor
ChEMBL 697 8 2 11 5.2 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@H]1C 10.1021/jm0304865
CHEMBL1628277 63043 0 None - 1 Human 8.5 pKi = 8.5 Binding
In vitro binding affinity towards human motilin receptorIn vitro binding affinity towards human motilin receptor
ChEMBL 697 8 2 11 5.2 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@H]1C 10.1021/jm0304865
44432974 94339 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 557 5 5 6 1.8 CNC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NCCOc2ccccc2CCCNC1=O 10.1016/j.bmcl.2007.05.043
CHEMBL233560 94339 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 557 5 5 6 1.8 CNC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NCCOc2ccccc2CCCNC1=O 10.1016/j.bmcl.2007.05.043
11995041 87257 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 524 5 5 6 2.9 CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2CCCNC1=O 10.1021/jm0606600
CHEMBL214685 87257 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 524 5 5 6 2.9 CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2CCCNC1=O 10.1021/jm0606600
11995357 148229 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 528 5 4 5 3.5 CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](CC2CCCCC2)NCCOc2ccccc2CCCNC1=O 10.1021/jm0606600
CHEMBL384204 148229 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 528 5 4 5 3.5 CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](CC2CCCCC2)NCCOc2ccccc2CCCNC1=O 10.1021/jm0606600
25114744 167544 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 599 6 7 6 1.5 CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(Cl)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CCNC(=N)N)NC1=O 10.1016/j.bmcl.2007.05.043
CHEMBL411409 167544 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 599 6 7 6 1.5 CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(Cl)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CCNC(=N)N)NC1=O 10.1016/j.bmcl.2007.05.043
11994678 148166 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 536 5 5 6 2.5 CCC[C@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC1=O 10.1021/jm0606600
CHEMBL383881 148166 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 536 5 5 6 2.5 CCC[C@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC1=O 10.1021/jm0606600
44432968 93724 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 539 5 6 7 1.0 CC(C)[C@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2CCCNC(=O)[C@H](CCN)NC1=O 10.1016/j.bmcl.2007.05.043
CHEMBL232342 93724 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 539 5 6 7 1.0 CC(C)[C@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2CCCNC(=O)[C@H](CCN)NC1=O 10.1016/j.bmcl.2007.05.043
11994556 87264 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 472 4 4 5 2.2 CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](C(C)C)NCCOc2ccccc2/C=C/CNC1=O 10.1021/jm0606600
CHEMBL214703 87264 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 472 4 4 5 2.2 CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](C(C)C)NCCOc2ccccc2/C=C/CNC1=O 10.1021/jm0606600
1048 8366 76 None - 1 Human 4.4 pKi = 4.4 Binding
In vitro binding affinity towards human motilin receptorIn vitro binding affinity towards human motilin receptor
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1021/jm0304865
12560 8366 76 None - 1 Human 4.4 pKi = 4.4 Binding
In vitro binding affinity towards human motilin receptorIn vitro binding affinity towards human motilin receptor
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1021/jm0304865
1456 8366 76 None - 1 Human 4.4 pKi = 4.4 Binding
In vitro binding affinity towards human motilin receptorIn vitro binding affinity towards human motilin receptor
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1021/jm0304865
CHEMBL532 8366 76 None - 1 Human 4.4 pKi = 4.4 Binding
In vitro binding affinity towards human motilin receptorIn vitro binding affinity towards human motilin receptor
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1021/jm0304865
DB00199 8366 76 None - 1 Human 4.4 pKi = 4.4 Binding
In vitro binding affinity towards human motilin receptorIn vitro binding affinity towards human motilin receptor
ChEMBL 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O 10.1021/jm0304865
44432970 93812 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 567 6 6 7 1.7 CC(C)NC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2CCCNC1=O 10.1016/j.bmcl.2007.05.043
CHEMBL232550 93812 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 567 6 6 7 1.7 CC(C)NC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2CCCNC1=O 10.1016/j.bmcl.2007.05.043
23656869 154634 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 631 5 4 6 3.1 CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(C(F)(F)F)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CN2CCCC2)NC1=O 10.1016/j.bmcl.2007.05.043
CHEMBL393315 154634 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 631 5 4 6 3.1 CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(C(F)(F)F)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CN2CCCC2)NC1=O 10.1016/j.bmcl.2007.05.043
44432979 155296 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 626 6 5 8 3.2 CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(Cl)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CNc2nccs2)NC1=O 10.1016/j.bmcl.2007.05.043
CHEMBL393842 155296 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 626 6 5 8 3.2 CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(Cl)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CNc2nccs2)NC1=O 10.1016/j.bmcl.2007.05.043
11398860 182824 0 None - 1 Human 5.4 pKi = 5.4 Binding
In vitro binding affinity towards human motilin receptorIn vitro binding affinity towards human motilin receptor
ChEMBL 560 8 3 10 0.4 NC(=O)[C@H](CCc1ccccc1)NC(=O)C1C=CC2(CCNCC2)n2c(=O)n(Cc3ccc4c(c3)OCO4)c(=O)n21 10.1021/jm0304865
CHEMBL45905 182824 0 None - 1 Human 5.4 pKi = 5.4 Binding
In vitro binding affinity towards human motilin receptorIn vitro binding affinity towards human motilin receptor
ChEMBL 560 8 3 10 0.4 NC(=O)[C@H](CCc1ccccc1)NC(=O)C1C=CC2(CCNCC2)n2c(=O)n(Cc3ccc4c(c3)OCO4)c(=O)n21 10.1021/jm0304865
11995154 87863 0 None - 1 Human 5.3 pKi = 5.3 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 566 7 6 7 1.7 CCC[C@@H]1NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC1=O 10.1021/jm0606600
CHEMBL215532 87863 0 None - 1 Human 5.3 pKi = 5.3 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 566 7 6 7 1.7 CCC[C@@H]1NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC1=O 10.1021/jm0606600
25115201 165553 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 611 5 6 8 1.2 CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(Cl)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CNC2=NCCN2)NC1=O 10.1016/j.bmcl.2007.05.043
CHEMBL409410 165553 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 611 5 6 8 1.2 CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(Cl)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CNC2=NCCN2)NC1=O 10.1016/j.bmcl.2007.05.043
44432978 93749 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 586 5 6 6 1.3 CC(C)[C@H]1NC(=O)[C@@H](Cc2ccc(Cl)cc2)NCCOc2ccccc2CCCNC(=O)[C@H](CNC(N)=O)NC1=O 10.1016/j.bmcl.2007.05.043
CHEMBL232359 93749 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 586 5 6 6 1.3 CC(C)[C@H]1NC(=O)[C@@H](Cc2ccc(Cl)cc2)NCCOc2ccccc2CCCNC(=O)[C@H](CNC(N)=O)NC1=O 10.1016/j.bmcl.2007.05.043
11226476 87950 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 538 5 5 6 2.5 CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2CCCNC1=O 10.1021/jm0606600
CHEMBL215825 87950 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 538 5 5 6 2.5 CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2CCCNC1=O 10.1021/jm0606600
11994925 87840 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 522 5 4 5 2.8 CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccccc2)NCCOc2ccccc2CCCNC1=O 10.1021/jm0606600
CHEMBL215440 87840 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 522 5 4 5 2.8 CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccccc2)NCCOc2ccccc2CCCNC1=O 10.1021/jm0606600
44432980 153674 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 585 5 7 6 1.1 CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(Cl)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CNC(=N)N)NC1=O 10.1016/j.bmcl.2007.05.043
CHEMBL392553 153674 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 585 5 7 6 1.1 CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(Cl)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CNC(=N)N)NC1=O 10.1016/j.bmcl.2007.05.043
11398860 182824 0 None - 1 Human 5.2 pKi = 5.2 Binding
In vitro binding affinity towards human motilin receptorIn vitro binding affinity towards human motilin receptor
ChEMBL 560 8 3 10 0.4 NC(=O)[C@H](CCc1ccccc1)NC(=O)C1C=CC2(CCNCC2)n2c(=O)n(Cc3ccc4c(c3)OCO4)c(=O)n21 10.1021/jm0304865
CHEMBL45905 182824 0 None - 1 Human 5.2 pKi = 5.2 Binding
In vitro binding affinity towards human motilin receptorIn vitro binding affinity towards human motilin receptor
ChEMBL 560 8 3 10 0.4 NC(=O)[C@H](CCc1ccccc1)NC(=O)C1C=CC2(CCNCC2)n2c(=O)n(Cc3ccc4c(c3)OCO4)c(=O)n21 10.1021/jm0304865
11204067 93560 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 585 5 7 6 1.1 CC(C)[C@H]1NC(=O)[C@@H](Cc2ccc(Cl)cc2)NCCOc2ccccc2CCCNC(=O)[C@H](CNC(=N)N)NC1=O 10.1016/j.bmcl.2007.05.043
CHEMBL232154 93560 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 585 5 7 6 1.1 CC(C)[C@H]1NC(=O)[C@@H](Cc2ccc(Cl)cc2)NCCOc2ccccc2CCCNC(=O)[C@H](CNC(=N)N)NC1=O 10.1016/j.bmcl.2007.05.043
44432975 94515 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 591 5 5 6 2.2 CNC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2cccc(C(F)(F)F)c2)NCCOc2ccccc2CCCNC1=O 10.1016/j.bmcl.2007.05.043
CHEMBL233711 94515 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 591 5 5 6 2.2 CNC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2cccc(C(F)(F)F)c2)NCCOc2ccccc2CCCNC1=O 10.1016/j.bmcl.2007.05.043
44432977 158459 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 619 5 7 6 1.5 CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(C(F)(F)F)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CNC(=N)N)NC1=O 10.1016/j.bmcl.2007.05.043
CHEMBL396413 158459 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 619 5 7 6 1.5 CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(C(F)(F)F)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CNC(=N)N)NC1=O 10.1016/j.bmcl.2007.05.043
11168753 151729 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 543 4 5 6 1.6 CC(C)[C@H]1NC(=O)[C@@H](Cc2ccc(Cl)cc2)NCCOc2ccccc2CCCNC(=O)[C@H](CN)NC1=O 10.1016/j.bmcl.2007.05.043
CHEMBL391045 151729 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 543 4 5 6 1.6 CC(C)[C@H]1NC(=O)[C@@H](Cc2ccc(Cl)cc2)NCCOc2ccccc2CCCNC(=O)[C@H](CN)NC1=O 10.1016/j.bmcl.2007.05.043
11994802 88232 0 None - 1 Human 5.2 pKi = 5.2 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 536 5 5 5 3.0 CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCCCc2ccccc2CCNC1=O 10.1021/jm0606600
CHEMBL215963 88232 0 None - 1 Human 5.2 pKi = 5.2 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 536 5 5 5 3.0 CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCCCc2ccccc2CCNC1=O 10.1021/jm0606600
11994800 148570 0 None - 1 Human 5.2 pKi = 5.2 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 536 5 5 5 3.0 CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCc2ccccc2CCCCNC1=O 10.1021/jm0606600
CHEMBL386187 148570 0 None - 1 Human 5.2 pKi = 5.2 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 536 5 5 5 3.0 CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCc2ccccc2CCCCNC1=O 10.1021/jm0606600
11180385 88191 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 550 5 5 6 2.8 CC(C)C[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC1=O 10.1021/jm0606600
CHEMBL215946 88191 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 550 5 5 6 2.8 CC(C)C[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC1=O 10.1021/jm0606600
25114976 154792 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 594 5 4 7 2.5 CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(Cl)c2)NCCOc2ccccc2CCCNC(=O)[C@H](Cn2ccnc2)NC1=O 10.1016/j.bmcl.2007.05.043
CHEMBL393439 154792 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 594 5 4 7 2.5 CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(Cl)c2)NCCOc2ccccc2CCCNC(=O)[C@H](Cn2ccnc2)NC1=O 10.1016/j.bmcl.2007.05.043
44417633 148227 0 None - 1 Human 5.2 pKi = 5.2 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 580 5 4 6 2.7 CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)N(C(C)=O)CCOc2ccccc2CCCNC1=O 10.1021/jm0606600
CHEMBL384188 148227 0 None - 1 Human 5.2 pKi = 5.2 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 580 5 4 6 2.7 CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)N(C(C)=O)CCOc2ccccc2CCCNC1=O 10.1021/jm0606600
11398651 154909 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 543 4 5 6 1.6 CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(Cl)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CN)NC1=O 10.1016/j.bmcl.2007.05.043
CHEMBL393541 154909 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 543 4 5 6 1.6 CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(Cl)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CN)NC1=O 10.1016/j.bmcl.2007.05.043
11995156 148542 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 524 4 6 7 0.7 CC(C)[C@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC(=O)[C@H](CO)NC1=O 10.1021/jm0606600
CHEMBL386036 148542 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 524 4 6 7 0.7 CC(C)[C@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC(=O)[C@H](CO)NC1=O 10.1021/jm0606600
11994679 87169 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 565 7 6 7 1.9 CC(C)[C@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC(=O)[C@H](CCCCN)NC1=O 10.1021/jm0606600
CHEMBL214508 87169 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 565 7 6 7 1.9 CC(C)[C@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC(=O)[C@H](CCCCN)NC1=O 10.1021/jm0606600
11994679 87169 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 565 7 6 7 1.9 CC(C)[C@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC(=O)[C@H](CCCCN)NC1=O 10.1016/j.bmcl.2007.05.043
CHEMBL214508 87169 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 565 7 6 7 1.9 CC(C)[C@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC(=O)[C@H](CCCCN)NC1=O 10.1016/j.bmcl.2007.05.043
11994924 87185 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 444 5 5 5 1.4 CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NC/C=C/CCNC1=O 10.1021/jm0606600
CHEMBL214555 87185 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 444 5 5 5 1.4 CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NC/C=C/CCNC1=O 10.1021/jm0606600
44417743 172886 0 None - 1 Human 5.1 pKi = 5.1 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 548 5 5 5 3.5 CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCCc2ccccc2/C=C\CCNC1=O 10.1021/jm0606600
CHEMBL425988 172886 0 None - 1 Human 5.1 pKi = 5.1 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 548 5 5 5 3.5 CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCCc2ccccc2/C=C\CCNC1=O 10.1021/jm0606600
11203197 87368 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 520 5 4 5 2.8 CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccccc2)NCCOc2ccccc2/C=C/CNC1=O 10.1021/jm0606600
CHEMBL215016 87368 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 520 5 4 5 2.8 CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccccc2)NCCOc2ccccc2/C=C/CNC1=O 10.1021/jm0606600
11994927 88539 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 572 5 4 5 3.9 CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NCCOc2ccccc2CCCNC1=O 10.1021/jm0606600
CHEMBL216400 88539 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 572 5 4 5 3.9 CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NCCOc2ccccc2CCCNC1=O 10.1021/jm0606600
11341873 148282 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 552 6 4 6 2.8 CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(OC)cc2)NCCOc2ccccc2CCCNC1=O 10.1021/jm0606600
CHEMBL384501 148282 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 552 6 4 6 2.8 CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(OC)cc2)NCCOc2ccccc2CCCNC1=O 10.1021/jm0606600
11433096 148381 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 572 5 4 5 3.9 CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2cccc3ccccc23)NCCOc2ccccc2CCCNC1=O 10.1021/jm0606600
CHEMBL385087 148381 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 572 5 4 5 3.9 CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2cccc3ccccc23)NCCOc2ccccc2CCCNC1=O 10.1021/jm0606600
25115427 105434 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 625 5 6 8 1.5 CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(Cl)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CNC2=NCCCN2)NC1=O 10.1016/j.bmcl.2007.05.043
CHEMBL277329 105434 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 625 5 6 8 1.5 CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(Cl)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CNC2=NCCCN2)NC1=O 10.1016/j.bmcl.2007.05.043
44432967 152349 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 551 6 6 7 1.5 CC(C)[C@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC(=O)[C@H](CCCN)NC1=O 10.1016/j.bmcl.2007.05.043
CHEMBL391524 152349 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells
ChEMBL 551 6 6 7 1.5 CC(C)[C@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC(=O)[C@H](CCCN)NC1=O 10.1016/j.bmcl.2007.05.043
11995259 87543 0 None - 1 Human 5.0 pKi = 5.0 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 520 5 5 5 2.7 CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCc2ccccc2/C=C/CNC1=O 10.1021/jm0606600
CHEMBL215177 87543 0 None - 1 Human 5.0 pKi = 5.0 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 520 5 5 5 2.7 CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCc2ccccc2/C=C/CNC1=O 10.1021/jm0606600
11995261 87541 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 524 5 5 6 2.1 CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2CCNC1=O 10.1021/jm0606600
CHEMBL215169 87541 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR
ChEMBL 524 5 5 6 2.1 CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2CCNC1=O 10.1021/jm0606600
101635584 9376 31 None - 1 Human 10.0 pKd = 10 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10381885
1458 9376 31 None - 1 Human 10.0 pKd = 10 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10381885
16136567 9376 31 None - 1 Human 10.0 pKd = 10 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10381885
3794 9376 31 None - 1 Human 10.0 pKd = 10 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10381885
91898963 9376 31 None - 1 Human 10.0 pKd = 10 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10381885
CHEMBL525634 9376 31 None - 1 Human 10.0 pKd = 10 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10381885
1048 8366 76 None - 1 Human 8.4 pKi = 8.4 Binding
In vitro binding affinity towards human motilin receptorIn vitro binding affinity towards human motilin receptor
Drug Central 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O None
12560 8366 76 None - 1 Human 8.4 pKi = 8.4 Binding
In vitro binding affinity towards human motilin receptorIn vitro binding affinity towards human motilin receptor
Drug Central 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O None
1456 8366 76 None - 1 Human 8.4 pKi = 8.4 Binding
In vitro binding affinity towards human motilin receptorIn vitro binding affinity towards human motilin receptor
Drug Central 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O None
CHEMBL532 8366 76 None - 1 Human 8.4 pKi = 8.4 Binding
In vitro binding affinity towards human motilin receptorIn vitro binding affinity towards human motilin receptor
Drug Central 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O None
DB00199 8366 76 None - 1 Human 8.4 pKi = 8.4 Binding
In vitro binding affinity towards human motilin receptorIn vitro binding affinity towards human motilin receptor
Drug Central 733 7 5 14 1.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O None
2139 10627 56 None 1 4 Rat 8.1 pKi = 8.1 Binding
Inhibitory constant against thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells upon incubation at 37 degree C for 1 hr at pH 7.4 using [3H]Ntau(1)-Me-His-TRHInhibitory constant against thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells upon incubation at 37 degree C for 1 hr at pH 7.4 using [3H]Ntau(1)-Me-His-TRH
Drug Central None None None None None
2316 10627 56 None 1 4 Rat 8.1 pKi = 8.1 Binding
Inhibitory constant against thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells upon incubation at 37 degree C for 1 hr at pH 7.4 using [3H]Ntau(1)-Me-His-TRHInhibitory constant against thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells upon incubation at 37 degree C for 1 hr at pH 7.4 using [3H]Ntau(1)-Me-His-TRH
Drug Central None None None None None
3836 10627 56 None 1 4 Rat 8.1 pKi = 8.1 Binding
Inhibitory constant against thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells upon incubation at 37 degree C for 1 hr at pH 7.4 using [3H]Ntau(1)-Me-His-TRHInhibitory constant against thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells upon incubation at 37 degree C for 1 hr at pH 7.4 using [3H]Ntau(1)-Me-His-TRH
Drug Central None None None None None
638678 10627 56 None 1 4 Rat 8.1 pKi = 8.1 Binding
Inhibitory constant against thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells upon incubation at 37 degree C for 1 hr at pH 7.4 using [3H]Ntau(1)-Me-His-TRHInhibitory constant against thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells upon incubation at 37 degree C for 1 hr at pH 7.4 using [3H]Ntau(1)-Me-His-TRH
Drug Central None None None None None
CHEMBL1472 10627 56 None 1 4 Rat 8.1 pKi = 8.1 Binding
Inhibitory constant against thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells upon incubation at 37 degree C for 1 hr at pH 7.4 using [3H]Ntau(1)-Me-His-TRHInhibitory constant against thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells upon incubation at 37 degree C for 1 hr at pH 7.4 using [3H]Ntau(1)-Me-His-TRH
Drug Central None None None None None
DB09421 10627 56 None 1 4 Rat 8.1 pKi = 8.1 Binding
Inhibitory constant against thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells upon incubation at 37 degree C for 1 hr at pH 7.4 using [3H]Ntau(1)-Me-His-TRHInhibitory constant against thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells upon incubation at 37 degree C for 1 hr at pH 7.4 using [3H]Ntau(1)-Me-His-TRH
Drug Central None None None None None
101635584 9376 31 None - 1 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11461914
101635584 9376 31 None - 1 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11781320
101635584 9376 31 None - 1 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15677347
101635584 9376 31 None - 1 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 16531413
1458 9376 31 None - 1 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11461914
1458 9376 31 None - 1 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11781320
1458 9376 31 None - 1 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15677347
1458 9376 31 None - 1 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 16531413
16136567 9376 31 None - 1 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11461914
16136567 9376 31 None - 1 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11781320
16136567 9376 31 None - 1 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15677347
16136567 9376 31 None - 1 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 16531413
3794 9376 31 None - 1 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11461914
3794 9376 31 None - 1 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11781320
3794 9376 31 None - 1 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15677347
3794 9376 31 None - 1 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 16531413
91898963 9376 31 None - 1 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11461914
91898963 9376 31 None - 1 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11781320
91898963 9376 31 None - 1 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15677347
91898963 9376 31 None - 1 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 16531413
CHEMBL525634 9376 31 None - 1 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11461914
CHEMBL525634 9376 31 None - 1 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11781320
CHEMBL525634 9376 31 None - 1 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15677347
CHEMBL525634 9376 31 None - 1 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 16531413
1450 10397 0 None - 1 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15677347
1451 10400 0 None - 1 Human 7.3 pKi None 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15677347
1452 7496 0 None - 1 Human 7.9 pKi None 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11461914