Biased Signaling Atlas

Ligand source activities (1 row/activity)

Potency
Affinity

Get vendors

Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	AssayType	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	101635584	2596	31	None	-	1	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay	ChEMBL		None	None	None		None	10.1021/jm801332q
	1458	2596	31	None	-	1	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay	ChEMBL		None	None	None		None	10.1021/jm801332q
	16136567	2596	31	None	-	1	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay	ChEMBL		None	None	None		None	10.1021/jm801332q
	3794	2596	31	None	-	1	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay	ChEMBL		None	None	None		None	10.1021/jm801332q
	91898963	2596	31	None	-	1	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay	ChEMBL		None	None	None		None	10.1021/jm801332q
	CHEMBL525634	2596	31	None	-	1	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay	ChEMBL		None	None	None		None	10.1021/jm801332q
	10010118	101435	0	None	-	1	Human	10.3	pEC50	=	10.3	Functional	In vitro effective concentration towards human motilin receptorIn vitro effective concentration towards human motilin receptor	ChEMBL	723	13	4	11	1.7	NC(=O)[C@H](CCc1ccccc1)NC(=O)[C@H](CCc1ccccc1)NC(=O)C1CCC2(CCNCC2)n2c(=O)n(Cc3ccc4c(c3)OCO4)c(=O)n21	10.1021/jm0304865
	CHEMBL297494	101435	0	None	-	1	Human	10.3	pEC50	=	10.3	Functional	In vitro effective concentration towards human motilin receptorIn vitro effective concentration towards human motilin receptor	ChEMBL	723	13	4	11	1.7	NC(=O)[C@H](CCc1ccccc1)NC(=O)[C@H](CCc1ccccc1)NC(=O)C1CCC2(CCNCC2)n2c(=O)n(Cc3ccc4c(c3)OCO4)c(=O)n21	10.1021/jm0304865
	CHEMBL2372767	210285	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	In vitro effective concentration towards human motilin receptorIn vitro effective concentration towards human motilin receptor	ChEMBL		None	None	None		CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccccc1)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)O)[C@@H](C)O	10.1021/jm0304865
	11181688	101335	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	In vitro effective concentration towards human motilin receptorIn vitro effective concentration towards human motilin receptor	ChEMBL	721	13	4	11	1.5	NC(=O)[C@H](CCc1ccccc1)NC(=O)[C@H](CCc1ccccc1)NC(=O)C1C=CC2(CCNCC2)n2c(=O)n(Cc3ccc4c(c3)OCO4)c(=O)n21	10.1021/jm0304865
	CHEMBL296748	101335	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	In vitro effective concentration towards human motilin receptorIn vitro effective concentration towards human motilin receptor	ChEMBL	721	13	4	11	1.5	NC(=O)[C@H](CCc1ccccc1)NC(=O)[C@H](CCc1ccccc1)NC(=O)C1C=CC2(CCNCC2)n2c(=O)n(Cc3ccc4c(c3)OCO4)c(=O)n21	10.1021/jm0304865
	23728661	88830	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	432	5	1	4	4.3	Cc1cc(N(C)C(=O)c2ccc(-c3cccc(F)c3)nc2)ccc1CN1CCN[C@@H](C)C1	10.6019/CHEMBL2364262
	CHEMBL2364292	88830	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	432	5	1	4	4.3	Cc1cc(N(C)C(=O)c2ccc(-c3cccc(F)c3)nc2)ccc1CN1CCN[C@@H](C)C1	10.6019/CHEMBL2364262
	23728772	88851	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	448	6	1	5	4.4	Cc1cc(N(C)C(=O)c2ccc(Oc3ccc(F)cc3)nc2)ccc1CN1CCN[C@@H](C)C1	10.6019/CHEMBL2364262
	CHEMBL2364312	88851	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	448	6	1	5	4.4	Cc1cc(N(C)C(=O)c2ccc(Oc3ccc(F)cc3)nc2)ccc1CN1CCN[C@@H](C)C1	10.6019/CHEMBL2364262
	23728875	88856	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	468	6	1	5	4.7	C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(Oc4ccc(F)cc4)nc3)cc2Cl)CCN1	10.6019/CHEMBL2364262
	CHEMBL2364317	88856	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	468	6	1	5	4.7	C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(Oc4ccc(F)cc4)nc3)cc2Cl)CCN1	10.6019/CHEMBL2364262
	10010118	101435	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	In vitro effective concentration towards human motilin receptorIn vitro effective concentration towards human motilin receptor	ChEMBL	723	13	4	11	1.7	NC(=O)[C@H](CCc1ccccc1)NC(=O)[C@H](CCc1ccccc1)NC(=O)C1CCC2(CCNCC2)n2c(=O)n(Cc3ccc4c(c3)OCO4)c(=O)n21	10.1021/jm0304865
	CHEMBL297494	101435	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	In vitro effective concentration towards human motilin receptorIn vitro effective concentration towards human motilin receptor	ChEMBL	723	13	4	11	1.7	NC(=O)[C@H](CCc1ccccc1)NC(=O)[C@H](CCc1ccccc1)NC(=O)C1CCC2(CCNCC2)n2c(=O)n(Cc3ccc4c(c3)OCO4)c(=O)n21	10.1021/jm0304865
	23728544	88823	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	446	5	1	4	4.7	Cc1nc(-c2ccc(F)cc2)ccc1C(=O)N(C)c1ccc(CN2C[C@H](C)N[C@H](C)C2)cc1	10.6019/CHEMBL2364262
	CHEMBL2364285	88823	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	446	5	1	4	4.7	Cc1nc(-c2ccc(F)cc2)ccc1C(=O)N(C)c1ccc(CN2C[C@H](C)N[C@H](C)C2)cc1	10.6019/CHEMBL2364262
	23728806	88857	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	448	7	1	5	4.5	CCN(C(=O)c1ccc(Oc2ccc(F)cc2)nc1)c1ccc(CN2CCN[C@@H](C)C2)cc1	10.6019/CHEMBL2364262
	CHEMBL2364318	88857	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	448	7	1	5	4.5	CCN(C(=O)c1ccc(Oc2ccc(F)cc2)nc1)c1ccc(CN2CCN[C@@H](C)C2)cc1	10.6019/CHEMBL2364262
	23729106	88820	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	432	5	1	4	4.3	Cc1nc(-c2cccc(F)c2)ccc1C(=O)N(C)c1ccc(CN2CCN[C@@H](C)C2)cc1	10.6019/CHEMBL2364262
	CHEMBL2364282	88820	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	432	5	1	4	4.3	Cc1nc(-c2cccc(F)c2)ccc1C(=O)N(C)c1ccc(CN2CCN[C@@H](C)C2)cc1	10.6019/CHEMBL2364262
	23728770	88840	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	432	6	1	4	4.3	CCN(C(=O)c1ccc(-c2cccc(F)c2)nc1)c1ccc(CN2CCN[C@@H](C)C2)cc1	10.6019/CHEMBL2364262
	CHEMBL2364302	88840	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	432	6	1	4	4.3	CCN(C(=O)c1ccc(-c2cccc(F)c2)nc1)c1ccc(CN2CCN[C@@H](C)C2)cc1	10.6019/CHEMBL2364262
	16749783	88869	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	450	6	1	7	3.2	C[C@H]1CN(Cc2ccn(-c3cccnc3N3CCC(Oc4cccc(F)c4)CC3)n2)CCN1	10.6019/CHEMBL2364262
	CHEMBL2364330	88869	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	450	6	1	7	3.2	C[C@H]1CN(Cc2ccn(-c3cccnc3N3CCC(Oc4cccc(F)c4)CC3)n2)CCN1	10.6019/CHEMBL2364262
	101635584	2596	31	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells	ChEMBL		None	None	None		None	10.1016/j.bmcl.2022.128554
	1458	2596	31	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells	ChEMBL		None	None	None		None	10.1016/j.bmcl.2022.128554
	16136567	2596	31	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells	ChEMBL		None	None	None		None	10.1016/j.bmcl.2022.128554
	3794	2596	31	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells	ChEMBL		None	None	None		None	10.1016/j.bmcl.2022.128554
	91898963	2596	31	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells	ChEMBL		None	None	None		None	10.1016/j.bmcl.2022.128554
	CHEMBL525634	2596	31	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells	ChEMBL		None	None	None		None	10.1016/j.bmcl.2022.128554
	23728693	88835	0	None	-	1	Human	9.0	pEC50	=	9	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	434	6	1	5	4.1	C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(Oc4cccc(F)c4)cn3)cc2)CCN1	10.6019/CHEMBL2364262
	CHEMBL2364297	88835	0	None	-	1	Human	9.0	pEC50	=	9	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	434	6	1	5	4.1	C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(Oc4cccc(F)c4)cn3)cc2)CCN1	10.6019/CHEMBL2364262
	16040758	88865	0	None	-	1	Human	9.0	pEC50	=	9	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	487	6	2	5	4.4	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)CCN1	10.6019/CHEMBL2364262
	CHEMBL2364326	88865	0	None	-	1	Human	9.0	pEC50	=	9	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	487	6	2	5	4.4	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)CCN1	10.6019/CHEMBL2364262
	23729022	88819	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	418	5	1	4	4.0	C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(-c4cccc(F)c4)nc3)cc2)CCN1	10.6019/CHEMBL2364262
	CHEMBL2364281	88819	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	418	5	1	4	4.0	C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(-c4cccc(F)c4)nc3)cc2)CCN1	10.6019/CHEMBL2364262
	23728731	88839	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	436	5	1	4	4.1	C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(-c4cccc(F)c4)nc3)cc2F)CCN1	10.6019/CHEMBL2364262
	CHEMBL2364301	88839	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	436	5	1	4	4.1	C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(-c4cccc(F)c4)nc3)cc2F)CCN1	10.6019/CHEMBL2364262
	16749753	88868	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	464	6	1	7	3.6	C[C@H]1CN(Cc2ccn(-c3cccnc3N3CCC(Oc4ccc(F)cc4)CC3)n2)C[C@@H](C)N1	10.6019/CHEMBL2364262
	CHEMBL2364329	88868	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	464	6	1	7	3.6	C[C@H]1CN(Cc2ccn(-c3cccnc3N3CCC(Oc4ccc(F)cc4)CC3)n2)C[C@@H](C)N1	10.6019/CHEMBL2364262
	23729025	88815	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	418	5	1	4	4.0	C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(-c4ccc(F)cc4)nc3)cc2)CCN1	10.6019/CHEMBL2364262
	CHEMBL2364277	88815	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	418	5	1	4	4.0	C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(-c4ccc(F)cc4)nc3)cc2)CCN1	10.6019/CHEMBL2364262
	23728541	88822	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	439	5	1	5	4.0	Cc1nc(-c2cccc(C#N)c2)ccc1C(=O)N(C)c1ccc(CN2CCN[C@@H](C)C2)cc1	10.6019/CHEMBL2364262
	CHEMBL2364284	88822	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	439	5	1	5	4.0	Cc1nc(-c2cccc(C#N)c2)ccc1C(=O)N(C)c1ccc(CN2CCN[C@@H](C)C2)cc1	10.6019/CHEMBL2364262
	23728581	88826	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	433	5	1	5	3.7	Cc1nc(-c2ccc(F)cc2)ncc1C(=O)N(C)c1ccc(CN2CCN[C@@H](C)C2)cc1	10.6019/CHEMBL2364262
	CHEMBL2364288	88826	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	433	5	1	5	3.7	Cc1nc(-c2ccc(F)cc2)ncc1C(=O)N(C)c1ccc(CN2CCN[C@@H](C)C2)cc1	10.6019/CHEMBL2364262
	42623380	88854	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	454	6	2	5	3.8	Cc1cc(NS(=O)(=O)c2ccc(-c3ccc(F)cc3)nc2)ccc1CN1CCN[C@@H](C)C1	10.6019/CHEMBL2364262
	CHEMBL2364315	88854	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	454	6	2	5	3.8	Cc1cc(NS(=O)(=O)c2ccc(-c3ccc(F)cc3)nc2)ccc1CN1CCN[C@@H](C)C1	10.6019/CHEMBL2364262
	42623463	88859	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	508	6	2	5	4.5	C[C@H]1CN(Cc2ccc(NS(=O)(=O)c3ccc(-c4ccc(F)cc4)nc3)cc2C(F)(F)F)CCN1	10.6019/CHEMBL2364262
	CHEMBL2364320	88859	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	508	6	2	5	4.5	C[C@H]1CN(Cc2ccc(NS(=O)(=O)c3ccc(-c4ccc(F)cc4)nc3)cc2C(F)(F)F)CCN1	10.6019/CHEMBL2364262
	56959013	191399	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells	ChEMBL	534	9	2	5	4.5	Cc1cc(N(C)C(=O)[C@H]2CC[C@H](Oc3cccc(CC(=O)NC(C)C)c3)CC2)ccc1CN1CCN[C@@H](C)C1	10.1016/j.bmcl.2022.128554
	CHEMBL5192530	191399	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells	ChEMBL	534	9	2	5	4.5	Cc1cc(N(C)C(=O)[C@H]2CC[C@H](Oc3cccc(CC(=O)NC(C)C)c3)CC2)ccc1CN1CCN[C@@H](C)C1	10.1016/j.bmcl.2022.128554
	89723534	190527	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells	ChEMBL	499	7	2	5	4.5	Cc1cc(N(C)C(=O)[C@H]2CC[C@H](Oc3ccc(Cl)c(CO)c3)CC2)ccc1CN1CCN[C@@H](C)C1	10.1016/j.bmcl.2022.128554
	CHEMBL5179573	190527	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells	ChEMBL	499	7	2	5	4.5	Cc1cc(N(C)C(=O)[C@H]2CC[C@H](Oc3ccc(Cl)c(CO)c3)CC2)ccc1CN1CCN[C@@H](C)C1	10.1016/j.bmcl.2022.128554
	16041119	178404	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	519	6	2	5	4.9	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(F)c(F)c4)CC3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	CHEMBL465917	178404	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	519	6	2	5	4.9	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(F)c(F)c4)CC3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	23728546	88824	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	432	5	1	4	4.3	C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(-c4ccc(F)cc4)nc3)cc2)C[C@@H](C)N1	10.6019/CHEMBL2364262
	CHEMBL2364286	88824	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	432	5	1	4	4.3	C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(-c4ccc(F)cc4)nc3)cc2)C[C@@H](C)N1	10.6019/CHEMBL2364262
	59262141	88837	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	441	6	1	6	3.8	C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(Oc4cccc(C#N)c4)cn3)cc2)CCN1	10.6019/CHEMBL2364262
	CHEMBL2364299	88837	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	441	6	1	6	3.8	C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(Oc4cccc(C#N)c4)cn3)cc2)CCN1	10.6019/CHEMBL2364262
	23728915	88860	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	449	6	1	6	3.8	Cc1cc(N(C)C(=O)c2ccc(Oc3ccc(F)cc3)nc2)ncc1CN1CCN[C@@H](C)C1	10.6019/CHEMBL2364262
	CHEMBL2364321	88860	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	449	6	1	6	3.8	Cc1cc(N(C)C(=O)c2ccc(Oc3ccc(F)cc3)nc2)ncc1CN1CCN[C@@H](C)C1	10.6019/CHEMBL2364262
	16122912	88862	1	None	-	1	Human	8.7	pEC50	=	8.7	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	463	6	2	7	3.7	C[C@H]1CN(Cc2ccn(-c3cccnc3N3CCC(Nc4ccc(F)cc4)CC3)n2)C[C@@H](C)N1	10.6019/CHEMBL2364262
	CHEMBL2364323	88862	1	None	-	1	Human	8.7	pEC50	=	8.7	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	463	6	2	7	3.7	C[C@H]1CN(Cc2ccn(-c3cccnc3N3CCC(Nc4ccc(F)cc4)CC3)n2)C[C@@H](C)N1	10.6019/CHEMBL2364262
	15984938	186787	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay	ChEMBL	424	6	2	4	3.3	C[C@H]1CN(Cc2ccc(CC(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)CCN1	10.1021/jm801332q
	CHEMBL489094	186787	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay	ChEMBL	424	6	2	4	3.3	C[C@H]1CN(Cc2ccc(CC(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)CCN1	10.1021/jm801332q
	46882521	5711	0	None	158	2	Human	8.0	pEC50	=	8	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	458	6	2	4	4.5	O=S(=O)(Nc1ccc2c(c1)CCN(Cc1cc[nH]n1)CC2)c1ccc(-c2ccccc2)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1078207	5711	0	None	158	2	Human	8.0	pEC50	=	8	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	458	6	2	4	4.5	O=S(=O)(Nc1ccc2c(c1)CCN(Cc1cc[nH]n1)CC2)c1ccc(-c2ccccc2)cc1	10.1016/j.bmcl.2009.09.027
	16752689	188368	0	None	5	3	Human	8.0	pEC50	=	8	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	568	10	2	4	6.6	COc1cccc(CCN(Cc2ccccc2-c2ccc(CN3C[C@H](C)N[C@H](C)C3)cc2)C(=O)NC2CCCCC2)c1	10.1016/j.bmcl.2008.10.072
	CHEMBL501315	188368	0	None	5	3	Human	8.0	pEC50	=	8	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	568	10	2	4	6.6	COc1cccc(CCN(Cc2ccccc2-c2ccc(CN3C[C@H](C)N[C@H](C)C3)cc2)C(=O)NC2CCCCC2)c1	10.1016/j.bmcl.2008.10.072
	16752689	188368	0	None	5	3	Human	8.0	pEC50	=	8	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay	ChEMBL	568	10	2	4	6.6	COc1cccc(CCN(Cc2ccccc2-c2ccc(CN3C[C@H](C)N[C@H](C)C3)cc2)C(=O)NC2CCCCC2)c1	10.1016/j.bmcl.2008.10.071
	CHEMBL501315	188368	0	None	5	3	Human	8.0	pEC50	=	8	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay	ChEMBL	568	10	2	4	6.6	COc1cccc(CCN(Cc2ccccc2-c2ccc(CN3C[C@H](C)N[C@H](C)C3)cc2)C(=O)NC2CCCCC2)c1	10.1016/j.bmcl.2008.10.071
	16040941	178288	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	519	6	2	5	4.9	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4cccc(F)c4)CC3)cc2F)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	CHEMBL465094	178288	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	519	6	2	5	4.9	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4cccc(F)c4)CC3)cc2F)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	11993730	178407	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	500	6	1	4	5.2	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Cc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	CHEMBL465925	178407	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	500	6	1	4	5.2	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Cc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	44570412	178421	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	505	8	1	5	4.0	C[C@H]1CN(Cc2ccc(-c3ccccc3CN(C)C(=O)CS(=O)(=O)c3ccccc3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	CHEMBL465948	178421	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	505	8	1	5	4.0	C[C@H]1CN(Cc2ccc(-c3ccccc3CN(C)C(=O)CS(=O)(=O)c3ccccc3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	44570489	183059	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	499	6	1	3	5.8	C[C@H]1CN(Cc2ccc(-c3ccccc3C(=O)N3CCC(Cc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	CHEMBL479418	183059	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	499	6	1	3	5.8	C[C@H]1CN(Cc2ccc(-c3ccccc3C(=O)N3CCC(Cc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	15985000	88806	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	474	6	2	4	4.1	C[C@H]1CN(Cc2ccc(CC(=O)N3CCC(Nc4ccc(C(F)(F)F)cc4)CC3)cc2)CCN1	10.6019/CHEMBL2364262
	CHEMBL2364268	88806	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	474	6	2	4	4.1	C[C@H]1CN(Cc2ccc(CC(=O)N3CCC(Nc4ccc(C(F)(F)F)cc4)CC3)cc2)CCN1	10.6019/CHEMBL2364262
	44571939	180616	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assay	ChEMBL	540	10	2	4	5.9	COc1cccc(CCN(Cc2ccccc2-c2ccc(CN3CCNCC3)cc2)C(=O)NC2CCCCC2)c1	10.1016/j.bmcl.2008.10.071
	CHEMBL475467	180616	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assay	ChEMBL	540	10	2	4	5.9	COc1cccc(CCN(Cc2ccccc2-c2ccc(CN3CCNCC3)cc2)C(=O)NC2CCCCC2)c1	10.1016/j.bmcl.2008.10.071
	52946479	17231	0	None	-	1	Rabbit	7.0	pEC50	=	7	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction	ChEMBL	794	9	7	15	1.7	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC(C)(C)O)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2010.08.030
	CHEMBL1256547	17231	0	None	-	1	Rabbit	7.0	pEC50	=	7	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction	ChEMBL	794	9	7	15	1.7	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC(C)(C)O)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2010.08.030
	52946426	17239	0	None	-	1	Rabbit	7.0	pEC50	=	7	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction	ChEMBL	778	9	6	14	2.6	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC(C)(C)O)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@H]1C	10.1016/j.bmcl.2010.08.030
	CHEMBL1256558	17239	0	None	-	1	Rabbit	7.0	pEC50	=	7	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction	ChEMBL	778	9	6	14	2.6	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC(C)(C)O)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@H]1C	10.1016/j.bmcl.2010.08.030
	54584627	62227	0	None	-	1	Rabbit	7.0	pEC50	=	7	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	794	9	7	15	1.7	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC(C)(C)O)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2011.04.078
	CHEMBL1778155	62227	0	None	-	1	Rabbit	7.0	pEC50	=	7	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	794	9	7	15	1.7	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC(C)(C)O)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2011.04.078
	42623375	88831	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	429	6	2	6	2.7	C[C@H]1CN(Cc2ccc(NS(=O)(=O)c3ccc(N4CCCCC4)nc3)cc2)CCN1	10.6019/CHEMBL2364262
	CHEMBL2364293	88831	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	429	6	2	6	2.7	C[C@H]1CN(Cc2ccc(NS(=O)(=O)c3ccc(N4CCCCC4)nc3)cc2)CCN1	10.6019/CHEMBL2364262
	44570112	177429	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	513	7	2	6	4.7	COc1ccc(NC2CCN(C(=O)c3ncccc3-c3ccc(CN4C[C@H](C)N[C@H](C)C4)cc3)CC2)cc1	10.1016/j.bmcl.2008.10.072
	CHEMBL463861	177429	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	513	7	2	6	4.7	COc1ccc(NC2CCN(C(=O)c3ncccc3-c3ccc(CN4C[C@H](C)N[C@H](C)C4)cc3)CC2)cc1	10.1016/j.bmcl.2008.10.072
	44570452	189832	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	446	7	1	5	4.0	Cc1cc(CC(=O)N(C)Cc2ccccc2-c2ccc(CN3C[C@H](C)N[C@H](C)C3)cc2)on1	10.1016/j.bmcl.2008.10.072
	CHEMBL516551	189832	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	446	7	1	5	4.0	Cc1cc(CC(=O)N(C)Cc2ccccc2-c2ccc(CN3C[C@H](C)N[C@H](C)C3)cc2)on1	10.1016/j.bmcl.2008.10.072
	44571990	189696	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assay	ChEMBL	533	11	1	4	5.6	COc1cccc(CCN(Cc2ccccc2-c2ccc(CN3CCNCC3)cc2)C(=O)Cc2ccccc2)c1	10.1016/j.bmcl.2008.10.071
	CHEMBL515434	189696	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assay	ChEMBL	533	11	1	4	5.6	COc1cccc(CCN(Cc2ccccc2-c2ccc(CN3CCNCC3)cc2)C(=O)Cc2ccccc2)c1	10.1016/j.bmcl.2008.10.071
	1048	1585	76	None	2	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at motilin receptorAgonist activity at motilin receptor	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1016/j.bmc.2010.08.035
	1048	1585	76	None	2	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at motilin receptorAgonist activity at motilin receptor	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1016/j.bmcl.2011.04.078
	12560	1585	76	None	2	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at motilin receptorAgonist activity at motilin receptor	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1016/j.bmc.2010.08.035
	12560	1585	76	None	2	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at motilin receptorAgonist activity at motilin receptor	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1016/j.bmcl.2011.04.078
	1456	1585	76	None	2	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at motilin receptorAgonist activity at motilin receptor	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1016/j.bmc.2010.08.035
	1456	1585	76	None	2	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at motilin receptorAgonist activity at motilin receptor	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1016/j.bmcl.2011.04.078
	CHEMBL532	1585	76	None	2	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at motilin receptorAgonist activity at motilin receptor	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1016/j.bmc.2010.08.035
	CHEMBL532	1585	76	None	2	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at motilin receptorAgonist activity at motilin receptor	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1016/j.bmcl.2011.04.078
	DB00199	1585	76	None	2	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at motilin receptorAgonist activity at motilin receptor	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1016/j.bmc.2010.08.035
	DB00199	1585	76	None	2	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at motilin receptorAgonist activity at motilin receptor	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1016/j.bmcl.2011.04.078
	52944056	17235	0	None	-	1	Rabbit	7.0	pEC50	=	7.0	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction	ChEMBL	748	8	5	13	3.2	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@H]1C	10.1016/j.bmcl.2010.08.030
	CHEMBL1256554	17235	0	None	-	1	Rabbit	7.0	pEC50	=	7.0	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction	ChEMBL	748	8	5	13	3.2	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@H]1C	10.1016/j.bmcl.2010.08.030
	168288449	191696	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells	ChEMBL	475	7	1	6	4.0	CC[C@H]1CN(Cc2ccc(N(C)C(=O)[C@H]3CC[C@H](Oc4ccnc(C#N)c4)CC3)cc2C)CCN1	10.1016/j.bmcl.2022.128554
	CHEMBL5196819	191696	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells	ChEMBL	475	7	1	6	4.0	CC[C@H]1CN(Cc2ccc(N(C)C(=O)[C@H]3CC[C@H](Oc4ccnc(C#N)c4)CC3)cc2C)CCN1	10.1016/j.bmcl.2022.128554
	15984937	785	31	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay	ChEMBL	424	6	2	4	3.3	C[C@@H]1NCCN(C1)Cc1ccc(cc1)CC(=O)N1CCC(CC1)Nc1cccc(c1)F	10.1021/jm801332q
	4035	785	31	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay	ChEMBL	424	6	2	4	3.3	C[C@@H]1NCCN(C1)Cc1ccc(cc1)CC(=O)N1CCC(CC1)Nc1cccc(c1)F	10.1021/jm801332q
	CHEMBL489095	785	31	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay	ChEMBL	424	6	2	4	3.3	C[C@@H]1NCCN(C1)Cc1ccc(cc1)CC(=O)N1CCC(CC1)Nc1cccc(c1)F	10.1021/jm801332q
	DB12567	785	31	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay	ChEMBL	424	6	2	4	3.3	C[C@@H]1NCCN(C1)Cc1ccc(cc1)CC(=O)N1CCC(CC1)Nc1cccc(c1)F	10.1021/jm801332q
	46882713	5731	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	395	4	1	3	4.2	O=S(=O)(Cc1ccc2c(c1)CCNCC2)c1ccc(-c2ccc(F)cc2)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1078345	5731	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	395	4	1	3	4.2	O=S(=O)(Cc1ccc2c(c1)CCNCC2)c1ccc(-c2ccc(F)cc2)cc1	10.1016/j.bmcl.2009.09.027
	15984136	88801	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	425	6	1	4	3.2	C[C@@H]1CN(Cc2ccc(CC(=O)N3CCC(Oc4ccc(F)cc4)CC3)cc2)CCN1	10.6019/CHEMBL2364262
	CHEMBL2364263	88801	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	425	6	1	4	3.2	C[C@@H]1CN(Cc2ccc(CC(=O)N3CCC(Oc4ccc(F)cc4)CC3)cc2)CCN1	10.6019/CHEMBL2364262
	15984135	88809	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	442	6	2	4	3.4	C[C@@H]1CN(Cc2ccc(CC(=O)N3CCC(Nc4ccc(F)c(F)c4)CC3)cc2)CCN1	10.6019/CHEMBL2364262
	CHEMBL2364271	88809	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	442	6	2	4	3.4	C[C@@H]1CN(Cc2ccc(CC(=O)N3CCC(Nc4ccc(F)c(F)c4)CC3)cc2)CCN1	10.6019/CHEMBL2364262
	15984138	88811	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	432	6	1	5	3.0	C[C@@H]1CN(Cc2ccc(CC(=O)N3CCC(Oc4ccc(C#N)cc4)CC3)cc2)CCN1	10.6019/CHEMBL2364262
	CHEMBL2364273	88811	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	432	6	1	5	3.0	C[C@@H]1CN(Cc2ccc(CC(=O)N3CCC(Oc4ccc(C#N)cc4)CC3)cc2)CCN1	10.6019/CHEMBL2364262
	23728769	88846	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	446	6	1	4	4.7	CC(C)N(C(=O)c1ccc(-c2cccc(F)c2)nc1)c1ccc(CN2CCN[C@@H](C)C2)cc1	10.6019/CHEMBL2364262
	CHEMBL2364308	88846	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	446	6	1	4	4.7	CC(C)N(C(=O)c1ccc(-c2cccc(F)c2)nc1)c1ccc(CN2CCN[C@@H](C)C2)cc1	10.6019/CHEMBL2364262
	54583621	62211	0	None	-	1	Rabbit	6.9	pEC50	=	6.9	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	760	8	5	13	3.5	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C3CCC3)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2011.04.078
	CHEMBL1778046	62211	0	None	-	1	Rabbit	6.9	pEC50	=	6.9	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	760	8	5	13	3.5	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C3CCC3)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2011.04.078
	44542067	198733	0	None	-	1	Rabbit	6.9	pEC50	=	6.9	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	865	13	7	16	1.5	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NCCO)[C@H](C)[C@@H](O)[C@]1(C)O	10.1021/jm901107f
	CHEMBL582871	198733	0	None	-	1	Rabbit	6.9	pEC50	=	6.9	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	865	13	7	16	1.5	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NCCO)[C@H](C)[C@@H](O)[C@]1(C)O	10.1021/jm901107f
	44542068	198734	0	None	-	1	Rabbit	6.9	pEC50	=	6.9	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	905	12	6	16	2.7	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NC2CCOCC2)[C@H](C)[C@@H](O)[C@]1(C)O	10.1021/jm901107f
	CHEMBL582872	198734	0	None	-	1	Rabbit	6.9	pEC50	=	6.9	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	905	12	6	16	2.7	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NC2CCOCC2)[C@H](C)[C@@H](O)[C@]1(C)O	10.1021/jm901107f
	1048	1585	76	None	-2	4	Rabbit	5.9	pEC50	=	5.9	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1016/j.bmcl.2010.08.030
	12560	1585	76	None	-2	4	Rabbit	5.9	pEC50	=	5.9	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1016/j.bmcl.2010.08.030
	1456	1585	76	None	-2	4	Rabbit	5.9	pEC50	=	5.9	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1016/j.bmcl.2010.08.030
	CHEMBL532	1585	76	None	-2	4	Rabbit	5.9	pEC50	=	5.9	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1016/j.bmcl.2010.08.030
	DB00199	1585	76	None	-2	4	Rabbit	5.9	pEC50	=	5.9	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1016/j.bmcl.2010.08.030
	1048	1585	76	None	-2	4	Rabbit	5.9	pEC50	=	5.9	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1016/j.bmcl.2011.04.078
	1048	1585	76	None	-2	4	Rabbit	5.9	pEC50	=	5.9	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1021/jm901107f
	12560	1585	76	None	-2	4	Rabbit	5.9	pEC50	=	5.9	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1016/j.bmcl.2011.04.078
	12560	1585	76	None	-2	4	Rabbit	5.9	pEC50	=	5.9	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1021/jm901107f
	1456	1585	76	None	-2	4	Rabbit	5.9	pEC50	=	5.9	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1016/j.bmcl.2011.04.078
	1456	1585	76	None	-2	4	Rabbit	5.9	pEC50	=	5.9	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1021/jm901107f
	CHEMBL532	1585	76	None	-2	4	Rabbit	5.9	pEC50	=	5.9	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1016/j.bmcl.2011.04.078
	CHEMBL532	1585	76	None	-2	4	Rabbit	5.9	pEC50	=	5.9	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1021/jm901107f
	DB00199	1585	76	None	-2	4	Rabbit	5.9	pEC50	=	5.9	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1016/j.bmcl.2011.04.078
	DB00199	1585	76	None	-2	4	Rabbit	5.9	pEC50	=	5.9	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1021/jm901107f
	46882672	5635	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	357	6	1	3	3.7	CCCCc1ccc(S(=O)(=O)Cc2ccc3c(c2)CCNCC3)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1077736	5635	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	357	6	1	3	3.7	CCCCc1ccc(S(=O)(=O)Cc2ccc3c(c2)CCNCC3)cc1	10.1016/j.bmcl.2009.09.027
	46882711	5729	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	351	3	1	3	3.5	O=S(=O)(Cc1ccc2c(c1)CCNCC2)c1ccc2ccccc2c1	10.1016/j.bmcl.2009.09.027
	CHEMBL1078343	5729	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	351	3	1	3	3.5	O=S(=O)(Cc1ccc2c(c1)CCNCC2)c1ccc2ccccc2c1	10.1016/j.bmcl.2009.09.027
	54583623	62213	0	None	-	1	Rabbit	6.9	pEC50	=	6.9	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	764	9	6	14	2.4	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C[C@H](C)O)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2011.04.078
	CHEMBL1778049	62213	0	None	-	1	Rabbit	6.9	pEC50	=	6.9	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	764	9	6	14	2.4	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C[C@H](C)O)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2011.04.078
	44542518	198162	0	None	-	1	Rabbit	6.9	pEC50	=	6.9	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	863	12	6	15	2.9	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NC(C)C)[C@H](C)[C@@H](O)[C@]1(C)O	10.1021/jm901107f
	CHEMBL574848	198162	0	None	-	1	Rabbit	6.9	pEC50	=	6.9	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	863	12	6	15	2.9	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NC(C)C)[C@H](C)[C@@H](O)[C@]1(C)O	10.1021/jm901107f
	16041292	183611	0	None	31	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	490	6	2	6	3.9	C[C@H]1CN(Cc2ccc(-n3ccnc3C(=O)N3CCC(Nc4cccc(F)c4)CC3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	CHEMBL480219	183611	0	None	31	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	490	6	2	6	3.9	C[C@H]1CN(Cc2ccc(-n3ccnc3C(=O)N3CCC(Nc4cccc(F)c4)CC3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	15984137	88810	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	425	6	1	4	3.2	C[C@@H]1CN(Cc2ccc(CC(=O)N3CCC(Oc4cccc(F)c4)CC3)cc2)CCN1	10.6019/CHEMBL2364262
	CHEMBL2364272	88810	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	425	6	1	4	3.2	C[C@@H]1CN(Cc2ccc(CC(=O)N3CCC(Oc4cccc(F)c4)CC3)cc2)CCN1	10.6019/CHEMBL2364262
	15984184	88812	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	431	6	2	5	3.0	C[C@@H]1CN(Cc2ccc(CC(=O)N3CCC(Nc4ccc(C#N)cc4)CC3)cc2)CCN1	10.6019/CHEMBL2364262
	CHEMBL2364274	88812	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	431	6	2	5	3.0	C[C@@H]1CN(Cc2ccc(CC(=O)N3CCC(Nc4ccc(C#N)cc4)CC3)cc2)CCN1	10.6019/CHEMBL2364262
	23728771	88852	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	462	8	1	5	4.0	COCCN(C(=O)c1ccc(-c2cccc(F)c2)nc1)c1ccc(CN2CCN[C@@H](C)C2)cc1	10.6019/CHEMBL2364262
	CHEMBL2364313	88852	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	462	8	1	5	4.0	COCCN(C(=O)c1ccc(-c2cccc(F)c2)nc1)c1ccc(CN2CCN[C@@H](C)C2)cc1	10.6019/CHEMBL2364262
	59262173	88855	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	478	9	1	6	4.1	COCCN(C(=O)c1ccc(Oc2ccc(F)cc2)nc1)c1ccc(CN2CCN[C@@H](C)C2)cc1	10.6019/CHEMBL2364262
	CHEMBL2364316	88855	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	478	9	1	6	4.1	COCCN(C(=O)c1ccc(Oc2ccc(F)cc2)nc1)c1ccc(CN2CCN[C@@H](C)C2)cc1	10.6019/CHEMBL2364262
	15984243	88871	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	452	6	2	4	4.2	CC(C(=O)N1CCC(Nc2cccc(F)c2)CC1)c1ccc(CN2C[C@H](C)N[C@H](C)C2)cc1	10.6019/CHEMBL2364262
	CHEMBL2364332	88871	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	452	6	2	4	4.2	CC(C(=O)N1CCC(Nc2cccc(F)c2)CC1)c1ccc(CN2C[C@H](C)N[C@H](C)C2)cc1	10.6019/CHEMBL2364262
	44542965	198769	0	None	-	1	Rabbit	6.8	pEC50	=	6.8	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	891	15	6	15	3.7	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCCCCCC(=O)NC)[C@H](C)[C@@H](O)[C@]1(C)O	10.1021/jm901107f
	CHEMBL583097	198769	0	None	-	1	Rabbit	6.8	pEC50	=	6.8	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	891	15	6	15	3.7	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCCCCCC(=O)NC)[C@H](C)[C@@H](O)[C@]1(C)O	10.1021/jm901107f
	44542966	197920	0	None	-	1	Rabbit	5.8	pEC50	=	5.8	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	911	12	6	15	3.9	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCc2ccc(C(=O)NC)cc2)[C@H](C)[C@@H](O)[C@]1(C)O	10.1021/jm901107f
	CHEMBL572998	197920	0	None	-	1	Rabbit	5.8	pEC50	=	5.8	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	911	12	6	15	3.9	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCc2ccc(C(=O)NC)cc2)[C@H](C)[C@@H](O)[C@]1(C)O	10.1021/jm901107f
	46882754	5721	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	403	4	1	5	3.3	N#Cc1ccc(-c2ccc(S(=O)(=O)Cc3ccc4c(c3)CCNCC4)cn2)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1078269	5721	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	403	4	1	5	3.3	N#Cc1ccc(-c2ccc(S(=O)(=O)Cc3ccc4c(c3)CCNCC4)cn2)cc1	10.1016/j.bmcl.2009.09.027
	46882794	5748	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	360	5	1	5	2.5	CC(C)Oc1ccc(S(=O)(=O)Cc2ccc3c(c2)CCNCC3)cn1	10.1016/j.bmcl.2009.09.027
	CHEMBL1078461	5748	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	360	5	1	5	2.5	CC(C)Oc1ccc(S(=O)(=O)Cc2ccc3c(c2)CCNCC3)cn1	10.1016/j.bmcl.2009.09.027
	42623379	88853	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	454	6	2	5	3.9	C[C@H]1CN(Cc2ccc(NS(=O)(=O)c3ccc(-c4ccc(F)cc4)nc3)cc2)C[C@@H](C)N1	10.6019/CHEMBL2364262
	CHEMBL2364314	88853	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	454	6	2	5	3.9	C[C@H]1CN(Cc2ccc(NS(=O)(=O)c3ccc(-c4ccc(F)cc4)nc3)cc2)C[C@@H](C)N1	10.6019/CHEMBL2364262
	46882623	5851	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	388	4	2	6	1.4	O=S(=O)(Nc1ccc2c(c1)CCNCC2)c1ccc(N2CCOCC2)nc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1079260	5851	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	388	4	2	6	1.4	O=S(=O)(Nc1ccc2c(c1)CCNCC2)c1ccc(N2CCOCC2)nc1	10.1016/j.bmcl.2009.09.027
	9863611	96930	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	358	6	2	3	3.5	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCNCC3)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL266018	96930	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	358	6	2	3	3.5	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCNCC3)cc1	10.1016/j.bmcl.2009.09.027
	44571376	184061	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assay	ChEMBL	510	9	2	3	5.8	O=C(NC1CCCCC1)N(CCc1ccccc1)Cc1ccccc1-c1cccc(CN2CCNCC2)c1	10.1016/j.bmcl.2008.10.071
	CHEMBL482307	184061	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assay	ChEMBL	510	9	2	3	5.8	O=C(NC1CCCCC1)N(CCc1ccccc1)Cc1ccccc1-c1cccc(CN2CCNCC2)c1	10.1016/j.bmcl.2008.10.071
	44542519	198924	0	None	-	1	Rabbit	6.8	pEC50	=	6.8	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	903	12	6	15	3.1	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NCC(F)(F)F)[C@H](C)[C@@H](O)[C@]1(C)O	10.1021/jm901107f
	CHEMBL584553	198924	0	None	-	1	Rabbit	6.8	pEC50	=	6.8	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	903	12	6	15	3.1	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NCC(F)(F)F)[C@H](C)[C@@H](O)[C@]1(C)O	10.1021/jm901107f
	54583624	62216	0	None	-	1	Rabbit	7.8	pEC50	=	7.8	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	819	11	5	14	3.2	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NC)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2011.04.078
	CHEMBL1778052	62216	0	None	-	1	Rabbit	7.8	pEC50	=	7.8	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	819	11	5	14	3.2	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NC)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2011.04.078
	168274082	190295	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells	ChEMBL	459	6	2	5	4.8	C[C@H]1CN(Cc2ccc(-c3cccnc3N3CCC(Nc4cccc(F)c4)CC3)cc2)CCN1	10.1016/j.bmcl.2022.128554
	CHEMBL5175905	190295	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells	ChEMBL	459	6	2	5	4.8	C[C@H]1CN(Cc2ccc(-c3cccnc3N3CCC(Nc4cccc(F)c4)CC3)cc2)CCN1	10.1016/j.bmcl.2022.128554
	52941569	17237	0	None	-	1	Rabbit	6.8	pEC50	=	6.8	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction	ChEMBL	764	9	6	14	2.2	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C[C@H](C)O)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@H]1C	10.1016/j.bmcl.2010.08.030
	CHEMBL1256556	17237	0	None	-	1	Rabbit	6.8	pEC50	=	6.8	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction	ChEMBL	764	9	6	14	2.2	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C[C@H](C)O)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@H]1C	10.1016/j.bmcl.2010.08.030
	15984134	193271	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay	ChEMBL	424	6	2	4	3.3	C[C@@H]1CN(Cc2ccc(CC(=O)N3CCC(Nc4cccc(F)c4)CC3)cc2)CCN1	10.1021/jm801332q
	CHEMBL523933	193271	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay	ChEMBL	424	6	2	4	3.3	C[C@@H]1CN(Cc2ccc(CC(=O)N3CCC(Nc4cccc(F)c4)CC3)cc2)CCN1	10.1021/jm801332q
	46882712	5730	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	411	4	1	3	4.7	O=S(=O)(Cc1ccc2c(c1)CCNCC2)c1ccc(-c2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1078344	5730	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	411	4	1	3	4.7	O=S(=O)(Cc1ccc2c(c1)CCNCC2)c1ccc(-c2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2009.09.027
	46882797	5751	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	411	5	2	5	3.6	O=S(=O)(Cc1ccc2c(c1)CCNCC2)c1ccc(Nc2ccc(F)cc2)nc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1078464	5751	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	411	5	2	5	3.6	O=S(=O)(Cc1ccc2c(c1)CCNCC2)c1ccc(Nc2ccc(F)cc2)nc1	10.1016/j.bmcl.2009.09.027
	44570450	177739	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	534	9	2	5	3.8	Cc1ccc(S(=O)(=O)NCC(=O)N(C)Cc2ccccc2-c2ccc(CN3C[C@H](C)N[C@H](C)C3)cc2)cc1	10.1016/j.bmcl.2008.10.072
	CHEMBL464247	177739	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	534	9	2	5	3.8	Cc1ccc(S(=O)(=O)NCC(=O)N(C)Cc2ccccc2-c2ccc(CN3C[C@H](C)N[C@H](C)C3)cc2)cc1	10.1016/j.bmcl.2008.10.072
	16041481	178805	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	508	6	2	6	4.5	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4cccc(C#N)c4)CC3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	CHEMBL469098	178805	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	508	6	2	6	4.5	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4cccc(C#N)c4)CC3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	16040587	179384	0	None	14	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	501	6	2	5	4.8	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	CHEMBL473921	179384	0	None	14	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	501	6	2	5	4.8	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	15984997	88804	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	425	6	1	4	3.2	C[C@H]1CN(Cc2ccc(CC(=O)N3CCC(Oc4ccc(F)cc4)CC3)cc2)CCN1	10.6019/CHEMBL2364262
	CHEMBL2364266	88804	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	425	6	1	4	3.2	C[C@H]1CN(Cc2ccc(CC(=O)N3CCC(Oc4ccc(F)cc4)CC3)cc2)CCN1	10.6019/CHEMBL2364262
	59262241	88849	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	495	6	1	4	5.0	C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(C(=O)c4ccc(C(F)(F)F)cc4)cc3)cc2)CCN1	10.6019/CHEMBL2364262
	CHEMBL2364310	88849	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	495	6	1	4	5.0	C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(C(=O)c4ccc(C(F)(F)F)cc4)cc3)cc2)CCN1	10.6019/CHEMBL2364262
	42623461	88861	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	454	6	2	5	3.8	Cc1cc(NS(=O)(=O)c2cncc(-c3ccc(F)cc3)c2)ccc1CN1CCN[C@@H](C)C1	10.6019/CHEMBL2364262
	CHEMBL2364322	88861	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	454	6	2	5	3.8	Cc1cc(NS(=O)(=O)c2cncc(-c3ccc(F)cc3)c2)ccc1CN1CCN[C@@H](C)C1	10.6019/CHEMBL2364262
	16041291	88864	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	555	7	2	6	4.5	C[C@H]1CN(Cc2ccc(-c3cccnc3S(=O)(=O)N3CCC(Nc4ccccc4F)CC3)cc2F)C[C@@H](C)N1	10.6019/CHEMBL2364262
	CHEMBL2364325	88864	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	555	7	2	6	4.5	C[C@H]1CN(Cc2ccc(-c3cccnc3S(=O)(=O)N3CCC(Nc4ccccc4F)CC3)cc2F)C[C@@H](C)N1	10.6019/CHEMBL2364262
	54581677	62217	0	None	-	1	Rabbit	6.7	pEC50	=	6.7	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	833	11	4	14	3.5	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)N(C)C)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2011.04.078
	CHEMBL1778053	62217	0	None	-	1	Rabbit	6.7	pEC50	=	6.7	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	833	11	4	14	3.5	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)N(C)C)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2011.04.078
	46882302	5766	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	426	7	1	3	5.2	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(C2CCCC2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1078558	5766	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	426	7	1	3	5.2	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(C2CCCC2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	46882755	5722	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	439	5	2	5	3.1	O=C(Nc1ccc(F)cc1)c1ccc(S(=O)(=O)Cc2ccc3c(c2)CCNCC3)cn1	10.1016/j.bmcl.2009.09.027
	CHEMBL1078270	5722	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	439	5	2	5	3.1	O=C(Nc1ccc(F)cc1)c1ccc(S(=O)(=O)Cc2ccc3c(c2)CCNCC3)cn1	10.1016/j.bmcl.2009.09.027
	46882303	5769	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	442	8	1	4	4.3	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(CC2CCOC2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1078586	5769	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	442	8	1	4	4.3	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(CC2CCOC2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	89723541	190525	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells	ChEMBL	473	6	1	4	4.9	C[C@H]1CN(Cc2ccc(N(C)C(=O)[C@H]3CC[C@H](Oc4ccc(F)cc4)CC3)cc2Cl)CCN1	10.1016/j.bmcl.2022.128554
	CHEMBL5179543	190525	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells	ChEMBL	473	6	1	4	4.9	C[C@H]1CN(Cc2ccc(N(C)C(=O)[C@H]3CC[C@H](Oc4ccc(F)cc4)CC3)cc2Cl)CCN1	10.1016/j.bmcl.2022.128554
	56960874	191114	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells	ChEMBL	453	6	1	4	4.5	Cc1cc(N(C)C(=O)[C@H]2CC[C@H](Oc3ccc(F)cc3)CC2)ccc1CN1CCN[C@@H](C)C1	10.1016/j.bmcl.2022.128554
	CHEMBL5187928	191114	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells	ChEMBL	453	6	1	4	4.5	Cc1cc(N(C)C(=O)[C@H]2CC[C@H](Oc3ccc(F)cc3)CC2)ccc1CN1CCN[C@@H](C)C1	10.1016/j.bmcl.2022.128554
	46882458	5978	0	None	31	2	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	438	8	2	4	4.2	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cc[nH]n2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1080046	5978	0	None	31	2	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	438	8	2	4	4.2	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cc[nH]n2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	44570527	190979	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	500	6	2	4	5.4	C[C@H]1CN(Cc2ccc(-c3ccccc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	CHEMBL518618	190979	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	500	6	2	4	5.4	C[C@H]1CN(Cc2ccc(-c3ccccc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	15984186	88814	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	474	6	2	4	4.1	C[C@@H]1CN(Cc2ccc(CC(=O)N3CCC(Nc4cccc(C(F)(F)F)c4)CC3)cc2)CCN1	10.6019/CHEMBL2364262
	CHEMBL2364276	88814	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	474	6	2	4	4.1	C[C@@H]1CN(Cc2ccc(CC(=O)N3CCC(Nc4cccc(C(F)(F)F)c4)CC3)cc2)CCN1	10.6019/CHEMBL2364262
	23729107	88821	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	433	6	1	4	4.7	C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(Oc4cccc(F)c4)cc3)cc2)CCN1	10.6019/CHEMBL2364262
	CHEMBL2364283	88821	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	433	6	1	4	4.7	C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(Oc4cccc(F)c4)cc3)cc2)CCN1	10.6019/CHEMBL2364262
	16749782	88867	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	464	6	1	7	3.6	C[C@H]1CN(Cc2ccn(-c3cccnc3N3CCC(Oc4cccc(F)c4)CC3)n2)C[C@@H](C)N1	10.6019/CHEMBL2364262
	CHEMBL2364328	88867	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	464	6	1	7	3.6	C[C@H]1CN(Cc2ccn(-c3cccnc3N3CCC(Oc4cccc(F)c4)CC3)n2)C[C@@H](C)N1	10.6019/CHEMBL2364262
	89723498	191405	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells	ChEMBL	492	9	2	5	5.0	CCOCc1cccc(N[C@H]2CC[C@H](C(=O)N(C)c3ccc(CN4CCN[C@@H](C)C4)c(C)c3)CC2)c1	10.1016/j.bmcl.2022.128554
	CHEMBL5192584	191405	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells	ChEMBL	492	9	2	5	5.0	CCOCc1cccc(N[C@H]2CC[C@H](C(=O)N(C)c3ccc(CN4CCN[C@@H](C)C4)c(C)c3)CC2)c1	10.1016/j.bmcl.2022.128554
	52942786	17223	0	None	-	1	Rabbit	5.7	pEC50	=	5.7	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction	ChEMBL	790	9	6	14	2.7	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC3(C)CC3)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2010.08.030
	CHEMBL1256538	17223	0	None	-	1	Rabbit	5.7	pEC50	=	5.7	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction	ChEMBL	790	9	6	14	2.7	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC3(C)CC3)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2010.08.030
	52943975	17226	0	None	-	1	Rabbit	6.7	pEC50	=	6.7	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction	ChEMBL	765	9	7	15	0.9	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCO)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2010.08.030
	CHEMBL1256542	17226	0	None	-	1	Rabbit	6.7	pEC50	=	6.7	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction	ChEMBL	765	9	7	15	0.9	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCO)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2010.08.030
	54586525	62219	0	None	-	1	Rabbit	6.7	pEC50	=	6.7	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	765	9	7	15	0.9	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCO)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2011.04.078
	CHEMBL1778055	62219	0	None	-	1	Rabbit	6.7	pEC50	=	6.7	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	765	9	7	15	0.9	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCO)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2011.04.078
	44542215	197132	0	None	-	1	Rabbit	5.7	pEC50	=	5.7	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	911	12	6	15	3.9	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCc2cccc(C(=O)NC)c2)[C@H](C)[C@@H](O)[C@]1(C)O	10.1021/jm901107f
	CHEMBL567808	197132	0	None	-	1	Rabbit	5.7	pEC50	=	5.7	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	911	12	6	15	3.9	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCc2cccc(C(=O)NC)c2)[C@H](C)[C@@H](O)[C@]1(C)O	10.1021/jm901107f
	54582662	62214	0	None	-	1	Rabbit	7.6	pEC50	=	7.6	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	778	9	6	14	2.7	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC(C)(C)O)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2011.04.078
	CHEMBL1778050	62214	0	None	-	1	Rabbit	7.6	pEC50	=	7.6	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	778	9	6	14	2.7	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC(C)(C)O)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2011.04.078
	168278248	191102	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells	ChEMBL	453	6	1	4	4.5	Cc1cc(CN2CCN[C@@H](C)C2)ccc1N(C)C(=O)[C@H]1CC[C@H](Oc2ccc(F)cc2)CC1	10.1016/j.bmcl.2022.128554
	CHEMBL5187776	191102	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells	ChEMBL	453	6	1	4	4.5	Cc1cc(CN2CCN[C@@H](C)C2)ccc1N(C)C(=O)[C@H]1CC[C@H](Oc2ccc(F)cc2)CC1	10.1016/j.bmcl.2022.128554
	52942785	17221	0	None	-	1	Rabbit	5.6	pEC50	=	5.6	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction	ChEMBL	776	9	6	14	2.5	C=C(C)CN(C)[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)[C@H](O[C@@H]3C[C@@](C)(OC)[C@@H](O)[C@H](C)O3)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)[C@@H](O)[C@H](C)C[C@@]2(C)O)[C@@H]1O	10.1016/j.bmcl.2010.08.030
	CHEMBL1256536	17221	0	None	-	1	Rabbit	5.6	pEC50	=	5.6	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction	ChEMBL	776	9	6	14	2.5	C=C(C)CN(C)[C@H]1C[C@@H](C)O[C@@H](O[C@@H]2[C@@H](C)[C@H](O[C@@H]3C[C@@](C)(OC)[C@@H](O)[C@H](C)O3)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)[C@@H](O)[C@H](C)C[C@@]2(C)O)[C@@H]1O	10.1016/j.bmcl.2010.08.030
	16088034	198766	0	None	-	1	Rabbit	7.6	pEC50	=	7.6	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	899	12	6	17	2.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)Nc2ccncn2)[C@H](C)[C@@H](O)[C@]1(C)O	10.1021/jm901107f
	CHEMBL583094	198766	0	None	-	1	Rabbit	7.6	pEC50	=	7.6	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	899	12	6	17	2.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)Nc2ccncn2)[C@H](C)[C@@H](O)[C@]1(C)O	10.1021/jm901107f
	15984241	179523	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay	ChEMBL	438	7	2	4	3.7	C[C@H]1CN(Cc2ccc(CCC(=O)N3CCC(Nc4cccc(F)c4)CC3)cc2)CCN1	10.1021/jm801332q
	CHEMBL474130	179523	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay	ChEMBL	438	7	2	4	3.7	C[C@H]1CN(Cc2ccc(CCC(=O)N3CCC(Nc4cccc(F)c4)CC3)cc2)CCN1	10.1021/jm801332q
	46882714	5691	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	413	4	1	3	4.3	O=S(=O)(Cc1ccc2c(c1)CCNCC2)c1ccc(-c2ccc(F)c(F)c2)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1077991	5691	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	413	4	1	3	4.3	O=S(=O)(Cc1ccc2c(c1)CCNCC2)c1ccc(-c2ccc(F)c(F)c2)cc1	10.1016/j.bmcl.2009.09.027
	15984998	88805	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	425	6	1	4	3.2	C[C@H]1CN(Cc2ccc(CC(=O)N3CCC(Oc4cccc(F)c4)CC3)cc2)CCN1	10.6019/CHEMBL2364262
	CHEMBL2364267	88805	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	425	6	1	4	3.2	C[C@H]1CN(Cc2ccc(CC(=O)N3CCC(Oc4cccc(F)c4)CC3)cc2)CCN1	10.6019/CHEMBL2364262
	15984187	88808	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	454	7	2	5	3.3	COc1cc(CC(=O)N2CCC(Nc3cccc(F)c3)CC2)ccc1CN1CCN[C@@H](C)C1	10.6019/CHEMBL2364262
	CHEMBL2364270	88808	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	454	7	2	5	3.3	COc1cc(CC(=O)N2CCC(Nc3cccc(F)c3)CC2)ccc1CN1CCN[C@@H](C)C1	10.6019/CHEMBL2364262
	16749728	88863	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	479	6	2	6	5.2	C[C@H]1CN(Cc2ccc(-c3cccnc3N3CCC(Nc4ccc(F)cc4)CC3)s2)C[C@@H](C)N1	10.6019/CHEMBL2364262
	CHEMBL2364324	88863	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	479	6	2	6	5.2	C[C@H]1CN(Cc2ccc(-c3cccnc3N3CCC(Nc4ccc(F)cc4)CC3)s2)C[C@@H](C)N1	10.6019/CHEMBL2364262
	15984319	88872	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	466	6	2	4	4.4	C[C@H]1CN(Cc2ccc(C(C)(C)C(=O)N3CCC(Nc4cccc(F)c4)CC3)cc2)C[C@@H](C)N1	10.6019/CHEMBL2364262
	CHEMBL2364333	88872	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	466	6	2	4	4.4	C[C@H]1CN(Cc2ccc(C(C)(C)C(=O)N3CCC(Nc4cccc(F)c4)CC3)cc2)C[C@@H](C)N1	10.6019/CHEMBL2364262
	52948855	17232	0	None	-	1	Rabbit	5.6	pEC50	=	5.6	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction	ChEMBL	795	10	8	16	0.3	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC(O)CO)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2010.08.030
	CHEMBL1256548	17232	0	None	-	1	Rabbit	5.6	pEC50	=	5.6	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction	ChEMBL	795	10	8	16	0.3	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC(O)CO)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2010.08.030
	44593551	37767	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	549	12	1	5	5.4	COc1cccc(CCN(Cc2ccccc2-c2ccc(CN3CCNCC3)cc2)C(=O)COc2ccccc2)c1	10.1016/j.bmcl.2008.10.072
	CHEMBL14581	37767	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	549	12	1	5	5.4	COc1cccc(CCN(Cc2ccccc2-c2ccc(CN3CCNCC3)cc2)C(=O)COc2ccccc2)c1	10.1016/j.bmcl.2008.10.072
	44570451	190504	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	421	8	1	3	4.9	CC(C)CCC(=O)N(C)Cc1ccccc1-c1ccc(CN2C[C@H](C)N[C@H](C)C2)cc1	10.1016/j.bmcl.2008.10.072
	CHEMBL517934	190504	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	421	8	1	3	4.9	CC(C)CCC(=O)N(C)Cc1ccccc1-c1ccc(CN2C[C@H](C)N[C@H](C)C2)cc1	10.1016/j.bmcl.2008.10.072
	44593551	37767	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assay	ChEMBL	549	12	1	5	5.4	COc1cccc(CCN(Cc2ccccc2-c2ccc(CN3CCNCC3)cc2)C(=O)COc2ccccc2)c1	10.1016/j.bmcl.2008.10.071
	CHEMBL14581	37767	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assay	ChEMBL	549	12	1	5	5.4	COc1cccc(CCN(Cc2ccccc2-c2ccc(CN3CCNCC3)cc2)C(=O)COc2ccccc2)c1	10.1016/j.bmcl.2008.10.071
	46882350	5806	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	454	8	1	4	5.5	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cccs2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1078882	5806	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	454	8	1	4	5.5	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cccs2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	46882624	5852	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	372	6	1	3	3.5	CCCCc1ccc(S(=O)(=O)N(C)c2ccc3c(c2)CCNCC3)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1079261	5852	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	372	6	1	3	3.5	CCCCc1ccc(S(=O)(=O)N(C)c2ccc3c(c2)CCNCC3)cc1	10.1016/j.bmcl.2009.09.027
	46882625	5853	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	388	4	2	6	1.4	O=S(=O)(Nc1ccc(N2CCOCC2)nc1)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.09.027
	CHEMBL1079262	5853	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	388	4	2	6	1.4	O=S(=O)(Nc1ccc(N2CCOCC2)nc1)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.09.027
	46882460	6310	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	396	6	2	4	3.0	O=S(=O)(Cc1ccccc1)Nc1ccc2c(c1)CCN(Cc1cc[nH]n1)CC2	10.1016/j.bmcl.2009.09.027
	CHEMBL1081859	6310	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	396	6	2	4	3.0	O=S(=O)(Cc1ccccc1)Nc1ccc2c(c1)CCN(Cc1cc[nH]n1)CC2	10.1016/j.bmcl.2009.09.027
	44570013	176867	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	526	7	3	6	3.7	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(C(N)=O)cc4)CC3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	CHEMBL461446	176867	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	526	7	3	6	3.7	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(C(N)=O)cc4)CC3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	44570608	190734	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	493	6	2	5	4.1	C[C@H]1CN(Cc2ccc(N3CCCC3C(=O)N3CCC(Nc4cccc(F)c4)CC3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	CHEMBL518261	190734	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	493	6	2	5	4.1	C[C@H]1CN(Cc2ccc(N3CCCC3C(=O)N3CCC(Nc4cccc(F)c4)CC3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	52947632	17219	0	None	-	1	Rabbit	6.6	pEC50	=	6.6	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction	ChEMBL	764	8	6	14	2.4	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2010.08.030
	CHEMBL1256534	17219	0	None	-	1	Rabbit	6.6	pEC50	=	6.6	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction	ChEMBL	764	8	6	14	2.4	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2010.08.030
	44542667	198920	0	None	-	1	Rabbit	6.6	pEC50	=	6.6	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	764	8	6	14	2.4	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2011.04.078
	44542667	198920	0	None	-	1	Rabbit	6.6	pEC50	=	6.6	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	764	8	6	14	2.4	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1021/jm901107f
	CHEMBL584549	198920	0	None	-	1	Rabbit	6.6	pEC50	=	6.6	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	764	8	6	14	2.4	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2011.04.078
	CHEMBL584549	198920	0	None	-	1	Rabbit	6.6	pEC50	=	6.6	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	764	8	6	14	2.4	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1021/jm901107f
	44542964	198768	0	None	-	1	Rabbit	6.6	pEC50	=	6.6	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	877	14	6	15	3.3	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCCCCC(=O)NC)[C@H](C)[C@@H](O)[C@]1(C)O	10.1021/jm901107f
	CHEMBL583096	198768	0	None	-	1	Rabbit	6.6	pEC50	=	6.6	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	877	14	6	15	3.3	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCCCCC(=O)NC)[C@H](C)[C@@H](O)[C@]1(C)O	10.1021/jm901107f
	44542520	198732	0	None	-	1	Rabbit	7.6	pEC50	=	7.6	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	875	12	6	15	3.0	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NC2CCC2)[C@H](C)[C@@H](O)[C@]1(C)O	10.1021/jm901107f
	CHEMBL582870	198732	0	None	-	1	Rabbit	7.6	pEC50	=	7.6	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	875	12	6	15	3.0	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NC2CCC2)[C@H](C)[C@@H](O)[C@]1(C)O	10.1021/jm901107f
	52942801	17238	0	None	-	1	Rabbit	6.6	pEC50	=	6.6	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction	ChEMBL	764	9	6	14	2.2	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C[C@@H](C)O)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@H]1C	10.1016/j.bmcl.2010.08.030
	CHEMBL1256557	17238	0	None	-	1	Rabbit	6.6	pEC50	=	6.6	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction	ChEMBL	764	9	6	14	2.2	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C[C@@H](C)O)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@H]1C	10.1016/j.bmcl.2010.08.030
	46882395	5843	0	None	1	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	452	8	2	4	4.5	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2[nH]cnc2C)CC3)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1079186	5843	0	None	1	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	452	8	2	4	4.5	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2[nH]cnc2C)CC3)cc1	10.1016/j.bmcl.2009.09.027
	44570411	178366	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	473	8	1	4	5.3	C[C@H]1CN(Cc2ccc(-c3ccccc3CN(C)C(=O)CSc3ccccc3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	CHEMBL465271	178366	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	473	8	1	4	5.3	C[C@H]1CN(Cc2ccc(-c3ccccc3CN(C)C(=O)CSc3ccccc3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	15984185	88813	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	431	6	2	5	3.0	C[C@@H]1CN(Cc2ccc(CC(=O)N3CCC(Nc4cccc(C#N)c4)CC3)cc2)CCN1	10.6019/CHEMBL2364262
	CHEMBL2364275	88813	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	431	6	2	5	3.0	C[C@@H]1CN(Cc2ccc(CC(=O)N3CCC(Nc4cccc(C#N)c4)CC3)cc2)CCN1	10.6019/CHEMBL2364262
	23728695	88833	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	441	6	1	6	3.8	C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(Oc4cccc(C#N)c4)nc3)cc2)CCN1	10.6019/CHEMBL2364262
	CHEMBL2364295	88833	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	441	6	1	6	3.8	C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(Oc4cccc(C#N)c4)nc3)cc2)CCN1	10.6019/CHEMBL2364262
	23728694	88836	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	452	6	1	5	4.2	C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(Oc4ccc(F)cc4)nc3)c(F)c2)CCN1	10.6019/CHEMBL2364262
	CHEMBL2364298	88836	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	452	6	1	5	4.2	C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(Oc4ccc(F)cc4)nc3)c(F)c2)CCN1	10.6019/CHEMBL2364262
	16040587	179384	0	None	14	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay	ChEMBL	501	6	2	5	4.8	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1	10.1021/jm801332q
	CHEMBL473921	179384	0	None	14	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay	ChEMBL	501	6	2	5	4.8	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1	10.1021/jm801332q
	15984939	186853	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay	ChEMBL	431	6	2	5	3.0	C[C@H]1CN(Cc2ccc(CC(=O)N3CCC(Nc4cccc(C#N)c4)CC3)cc2)CCN1	10.1021/jm801332q
	CHEMBL489480	186853	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay	ChEMBL	431	6	2	5	3.0	C[C@H]1CN(Cc2ccc(CC(=O)N3CCC(Nc4cccc(C#N)c4)CC3)cc2)CCN1	10.1021/jm801332q
	46882522	5712	0	None	39	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	440	7	2	5	3.6	CC(C)Oc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cc[nH]n2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1078208	5712	0	None	39	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	440	7	2	5	3.6	CC(C)Oc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cc[nH]n2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	16040939	190705	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	519	6	2	5	4.9	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2F)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	CHEMBL518229	190705	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	519	6	2	5	4.9	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2F)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	52946425	17236	0	None	-	1	Rabbit	6.5	pEC50	=	6.5	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction	ChEMBL	760	8	5	13	3.4	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C3CCC3)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@H]1C	10.1016/j.bmcl.2010.08.030
	CHEMBL1256555	17236	0	None	-	1	Rabbit	6.5	pEC50	=	6.5	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction	ChEMBL	760	8	5	13	3.4	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C3CCC3)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@H]1C	10.1016/j.bmcl.2010.08.030
	44541929	198731	0	None	-	1	Rabbit	7.5	pEC50	=	7.5	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	861	12	6	15	2.7	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NC2CC2)[C@H](C)[C@@H](O)[C@]1(C)O	10.1021/jm901107f
	CHEMBL582869	198731	0	None	-	1	Rabbit	7.5	pEC50	=	7.5	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	861	12	6	15	2.7	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NC2CC2)[C@H](C)[C@@H](O)[C@]1(C)O	10.1021/jm901107f
	15984242	186813	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay	ChEMBL	452	6	2	4	4.2	CC(C(=O)N1CCC(Nc2ccc(F)cc2)CC1)c1ccc(CN2C[C@H](C)N[C@H](C)C2)cc1	10.1021/jm801332q
	CHEMBL489297	186813	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay	ChEMBL	452	6	2	4	4.2	CC(C(=O)N1CCC(Nc2ccc(F)cc2)CC1)c1ccc(CN2C[C@H](C)N[C@H](C)C2)cc1	10.1021/jm801332q
	15984318	186852	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay	ChEMBL	466	6	2	4	4.4	C[C@H]1CN(Cc2ccc(C(C)(C)C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1	10.1021/jm801332q
	CHEMBL489479	186852	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay	ChEMBL	466	6	2	4	4.4	C[C@H]1CN(Cc2ccc(C(C)(C)C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1	10.1021/jm801332q
	46882583	5756	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	453	5	2	6	2.6	CN1CCOc2cc(S(=O)(=O)Nc3ccc4c(c3)CCN(Cc3cc[nH]n3)CC4)ccc21	10.1016/j.bmcl.2009.09.027
	CHEMBL1078491	5756	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	453	5	2	6	2.6	CN1CCOc2cc(S(=O)(=O)Nc3ccc4c(c3)CCN(Cc3cc[nH]n3)CC4)ccc21	10.1016/j.bmcl.2009.09.027
	44570365	178168	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	475	8	1	4	4.7	C[C@H]1CN(Cc2ccc(-c3ccccc3CN(C)C(=O)COc3ccc(F)cc3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	CHEMBL464909	178168	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	475	8	1	4	4.7	C[C@H]1CN(Cc2ccc(-c3ccccc3CN(C)C(=O)COc3ccc(F)cc3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	15984994	88802	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	431	6	2	5	3.0	C[C@H]1CN(Cc2ccc(CC(=O)N3CCC(Nc4ccc(C#N)cc4)CC3)cc2)CCN1	10.6019/CHEMBL2364262
	CHEMBL2364264	88802	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	431	6	2	5	3.0	C[C@H]1CN(Cc2ccc(CC(=O)N3CCC(Nc4ccc(C#N)cc4)CC3)cc2)CCN1	10.6019/CHEMBL2364262
	23728774	88841	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	435	6	1	6	3.5	C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(Oc4ccc(F)cc4)nc3)nc2)CCN1	10.6019/CHEMBL2364262
	CHEMBL2364303	88841	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	435	6	1	6	3.5	C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(Oc4ccc(F)cc4)nc3)nc2)CCN1	10.6019/CHEMBL2364262
	52950053	17222	0	None	-	1	Rabbit	6.5	pEC50	=	6.5	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction	ChEMBL	776	9	6	14	2.4	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC3CC3)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2010.08.030
	CHEMBL1256537	17222	0	None	-	1	Rabbit	6.5	pEC50	=	6.5	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction	ChEMBL	776	9	6	14	2.4	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC3CC3)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2010.08.030
	46882710	5728	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	357	3	1	3	3.6	CC(C)(C)c1ccc(S(=O)(=O)Cc2ccc3c(c2)CCNCC3)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1078342	5728	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	357	3	1	3	3.6	CC(C)(C)c1ccc(S(=O)(=O)Cc2ccc3c(c2)CCNCC3)cc1	10.1016/j.bmcl.2009.09.027
	46882457	5951	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	452	8	1	5	4.2	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cncn2C)CC3)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1079868	5951	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	452	8	1	5	4.2	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cncn2C)CC3)cc1	10.1016/j.bmcl.2009.09.027
	44572092	180546	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay	ChEMBL	487	14	0	4	5.0	COCCCN(Cc1ccccc1-c1ccc(CN(C)CCN(C)C)cc1)C(=O)Cc1ccccc1	10.1016/j.bmcl.2008.10.071
	CHEMBL475380	180546	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay	ChEMBL	487	14	0	4	5.0	COCCCN(Cc1ccccc1-c1ccc(CN(C)CCN(C)C)cc1)C(=O)Cc1ccccc1	10.1016/j.bmcl.2008.10.071
	89872388	190487	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells	ChEMBL	467	7	1	4	4.9	CC[C@H]1CN(Cc2ccc(N(C)C(=O)[C@H]3CC[C@H](Oc4ccc(F)cc4)CC3)cc2C)CCN1	10.1016/j.bmcl.2022.128554
	CHEMBL5179060	190487	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells	ChEMBL	467	7	1	4	4.9	CC[C@H]1CN(Cc2ccc(N(C)C(=O)[C@H]3CC[C@H](Oc4ccc(F)cc4)CC3)cc2C)CCN1	10.1016/j.bmcl.2022.128554
	52941620	17224	0	None	-	1	Rabbit	6.5	pEC50	=	6.5	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction	ChEMBL	776	8	6	14	2.5	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C3CCC3)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2010.08.030
	CHEMBL1256539	17224	0	None	-	1	Rabbit	6.5	pEC50	=	6.5	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction	ChEMBL	776	8	6	14	2.5	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C3CCC3)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2010.08.030
	54587558	62218	0	None	-	1	Rabbit	6.5	pEC50	=	6.5	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	776	8	6	14	2.5	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C3CCC3)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2011.04.078
	CHEMBL1778054	62218	0	None	-	1	Rabbit	6.5	pEC50	=	6.5	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	776	8	6	14	2.5	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C3CCC3)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2011.04.078
	54580662	62215	0	None	-	1	Rabbit	7.4	pEC50	=	7.4	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	805	11	5	14	2.9	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(N)=O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2011.04.078
	CHEMBL1778051	62215	0	None	-	1	Rabbit	7.4	pEC50	=	7.4	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	805	11	5	14	2.9	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(N)=O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2011.04.078
	52942788	17229	0	None	-	1	Rabbit	6.4	pEC50	=	6.4	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction	ChEMBL	780	9	7	15	1.3	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C[C@H](C)O)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2010.08.030
	CHEMBL1256545	17229	0	None	-	1	Rabbit	6.4	pEC50	=	6.4	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction	ChEMBL	780	9	7	15	1.3	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C[C@H](C)O)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2010.08.030
	54584626	62226	0	None	-	1	Rabbit	6.4	pEC50	=	6.4	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	780	9	7	15	1.3	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C[C@H](C)O)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2011.04.078
	CHEMBL1778154	62226	0	None	-	1	Rabbit	6.4	pEC50	=	6.4	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	780	9	7	15	1.3	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C[C@H](C)O)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2011.04.078
	52946408	17220	0	None	-	1	Rabbit	6.4	pEC50	=	6.4	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction	ChEMBL	778	9	6	14	2.6	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2010.08.030
	CHEMBL1256535	17220	0	None	-	1	Rabbit	6.4	pEC50	=	6.4	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction	ChEMBL	778	9	6	14	2.6	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2010.08.030
	52942789	17233	0	None	-	1	Rabbit	5.4	pEC50	=	5.4	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction	ChEMBL	767	9	6	14	1.9	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCF)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2010.08.030
	CHEMBL1256549	17233	0	None	-	1	Rabbit	5.4	pEC50	=	5.4	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction	ChEMBL	767	9	6	14	1.9	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCF)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2010.08.030
	15604512	180186	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay	ChEMBL	438	6	2	4	3.7	C[C@H]1CN(Cc2ccc(CC(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1	10.1021/jm801332q
	CHEMBL474934	180186	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay	ChEMBL	438	6	2	4	3.7	C[C@H]1CN(Cc2ccc(CC(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1	10.1021/jm801332q
	46882795	5749	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	374	6	1	5	2.8	CC(C)COc1ccc(S(=O)(=O)Cc2ccc3c(c2)CCNCC3)cn1	10.1016/j.bmcl.2009.09.027
	CHEMBL1078462	5749	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	374	6	1	5	2.8	CC(C)COc1ccc(S(=O)(=O)Cc2ccc3c(c2)CCNCC3)cn1	10.1016/j.bmcl.2009.09.027
	46882520	5856	0	None	1	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	430	5	2	4	3.8	Cc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cc[nH]n2)CC3)cc1Cl	10.1016/j.bmcl.2009.09.027
	CHEMBL1079311	5856	0	None	1	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	430	5	2	4	3.8	Cc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cc[nH]n2)CC3)cc1Cl	10.1016/j.bmcl.2009.09.027
	23729060	88816	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	417	5	1	3	4.6	C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(-c4ccc(F)cc4)cc3)cc2)CCN1	10.6019/CHEMBL2364262
	CHEMBL2364278	88816	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	417	5	1	3	4.6	C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(-c4ccc(F)cc4)cc3)cc2)CCN1	10.6019/CHEMBL2364262
	23728733	88842	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	445	6	1	5	3.2	C[C@H]1CN(Cc2ccc(N(C)C(=O)C3CCN(Cc4cccc(C#N)c4)CC3)cc2)CCN1	10.6019/CHEMBL2364262
	CHEMBL2364304	88842	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	445	6	1	5	3.2	C[C@H]1CN(Cc2ccc(N(C)C(=O)C3CCN(Cc4cccc(C#N)c4)CC3)cc2)CCN1	10.6019/CHEMBL2364262
	23728840	88847	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	425	5	1	5	3.7	C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(-c4cccc(C#N)c4)cn3)cc2)CCN1	10.6019/CHEMBL2364262
	CHEMBL2364309	88847	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	425	5	1	5	3.7	C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(-c4cccc(C#N)c4)cn3)cc2)CCN1	10.6019/CHEMBL2364262
	15984239	88870	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	452	7	2	4	4.0	C[C@H]1CN(Cc2ccc(CCC(=O)N3CCC(Nc4cccc(F)c4)CC3)cc2)C[C@@H](C)N1	10.6019/CHEMBL2364262
	CHEMBL2364331	88870	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	452	7	2	4	4.0	C[C@H]1CN(Cc2ccc(CCC(=O)N3CCC(Nc4cccc(F)c4)CC3)cc2)C[C@@H](C)N1	10.6019/CHEMBL2364262
	44571375	189675	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay	ChEMBL	539	10	2	3	7.0	COc1cccc(CCN(Cc2ccccc2-c2ccc(CC3CCNCC3)cc2)C(=O)NC2CCCCC2)c1	10.1016/j.bmcl.2008.10.071
	CHEMBL515275	189675	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay	ChEMBL	539	10	2	3	7.0	COc1cccc(CCN(Cc2ccccc2-c2ccc(CC3CCNCC3)cc2)C(=O)NC2CCCCC2)c1	10.1016/j.bmcl.2008.10.071
	44593552	178308	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	487	12	1	5	4.2	COCCCN(Cc1ccccc1-c1ccc(CN2CCNCC2)cc1)C(=O)COc1ccccc1	10.1016/j.bmcl.2008.10.072
	CHEMBL465104	178308	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	487	12	1	5	4.2	COCCCN(Cc1ccccc1-c1ccc(CN2CCNCC2)cc1)C(=O)COc1ccccc1	10.1016/j.bmcl.2008.10.072
	44570568	183902	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	507	6	2	6	4.8	C[C@H]1CN(Cc2cnc(-c3ccccc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)s2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	CHEMBL481192	183902	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	507	6	2	6	4.8	C[C@H]1CN(Cc2cnc(-c3ccccc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)s2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	44593552	178308	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assay	ChEMBL	487	12	1	5	4.2	COCCCN(Cc1ccccc1-c1ccc(CN2CCNCC2)cc1)C(=O)COc1ccccc1	10.1016/j.bmcl.2008.10.071
	CHEMBL465104	178308	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assay	ChEMBL	487	12	1	5	4.2	COCCCN(Cc1ccccc1-c1ccc(CN2CCNCC2)cc1)C(=O)COc1ccccc1	10.1016/j.bmcl.2008.10.071
	53322109	56269	0	None	1	2	Human	8.4	pEC50	=	8.4	Functional	In vitro effective concentration towards human motilin receptorIn vitro effective concentration towards human motilin receptor	ChEMBL	697	8	2	11	5.2	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@H]1C	10.1021/jm0304865
	CHEMBL1628277	56269	0	None	1	2	Human	8.4	pEC50	=	8.4	Functional	In vitro effective concentration towards human motilin receptorIn vitro effective concentration towards human motilin receptor	ChEMBL	697	8	2	11	5.2	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@H]1C	10.1021/jm0304865
	89723511	190044	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells	ChEMBL	507	8	2	5	4.7	Cc1cc(N(C)C(=O)[C@H]2CC[C@H](Oc3cccc(CC(C)(C)O)c3)CC2)ccc1CN1CCN[C@@H](C)C1	10.1016/j.bmcl.2022.128554
	CHEMBL5171964	190044	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells	ChEMBL	507	8	2	5	4.7	Cc1cc(N(C)C(=O)[C@H]2CC[C@H](Oc3cccc(CC(C)(C)O)c3)CC2)ccc1CN1CCN[C@@H](C)C1	10.1016/j.bmcl.2022.128554
	56960875	190871	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells	ChEMBL	454	6	1	5	3.9	Cc1cc(N(C)C(=O)[C@H]2CC[C@H](Oc3ccc(F)cn3)CC2)ccc1CN1CCN[C@@H](C)C1	10.1016/j.bmcl.2022.128554
	CHEMBL5184722	190871	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells	ChEMBL	454	6	1	5	3.9	Cc1cc(N(C)C(=O)[C@H]2CC[C@H](Oc3ccc(F)cn3)CC2)ccc1CN1CCN[C@@H](C)C1	10.1016/j.bmcl.2022.128554
	56961016	191709	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells	ChEMBL	479	8	2	5	3.9	Cc1cc(N(C)C(=O)[C@H]2CC[C@H](Oc3cccc(CCO)c3)CC2)ccc1CN1CCN[C@@H](C)C1	10.1016/j.bmcl.2022.128554
	CHEMBL5196982	191709	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells	ChEMBL	479	8	2	5	3.9	Cc1cc(N(C)C(=O)[C@H]2CC[C@H](Oc3cccc(CCO)c3)CC2)ccc1CN1CCN[C@@H](C)C1	10.1016/j.bmcl.2022.128554
	1048	1585	76	None	2	4	Human	6.4	pEC50	=	6.4	Functional	In vitro effective concentration towards human motilin receptorIn vitro effective concentration towards human motilin receptor	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1021/jm0304865
	12560	1585	76	None	2	4	Human	6.4	pEC50	=	6.4	Functional	In vitro effective concentration towards human motilin receptorIn vitro effective concentration towards human motilin receptor	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1021/jm0304865
	1456	1585	76	None	2	4	Human	6.4	pEC50	=	6.4	Functional	In vitro effective concentration towards human motilin receptorIn vitro effective concentration towards human motilin receptor	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1021/jm0304865
	CHEMBL532	1585	76	None	2	4	Human	6.4	pEC50	=	6.4	Functional	In vitro effective concentration towards human motilin receptorIn vitro effective concentration towards human motilin receptor	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1021/jm0304865
	DB00199	1585	76	None	2	4	Human	6.4	pEC50	=	6.4	Functional	In vitro effective concentration towards human motilin receptorIn vitro effective concentration towards human motilin receptor	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1021/jm0304865
	44292287	187580	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	In vitro effective concentration towards human motilin receptorIn vitro effective concentration towards human motilin receptor	ChEMBL	546	7	3	10	-0.0	NC(=O)[C@@H](Cc1ccccc1)NC(=O)C1C=CC2(CCNCC2)n2c(=O)n(Cc3ccc4c(c3)OCO4)c(=O)n21	10.1021/jm0304865
	CHEMBL49464	187580	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	In vitro effective concentration towards human motilin receptorIn vitro effective concentration towards human motilin receptor	ChEMBL	546	7	3	10	-0.0	NC(=O)[C@@H](Cc1ccccc1)NC(=O)C1C=CC2(CCNCC2)n2c(=O)n(Cc3ccc4c(c3)OCO4)c(=O)n21	10.1021/jm0304865
	89723443	190517	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells	ChEMBL	439	6	1	4	4.1	Cc1cc(N(C)C(=O)[C@H]2CC[C@H](Oc3ccc(F)cc3)CC2)ccc1CN1CCNCC1	10.1016/j.bmcl.2022.128554
	CHEMBL5179463	190517	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells	ChEMBL	439	6	1	4	4.1	Cc1cc(N(C)C(=O)[C@H]2CC[C@H](Oc3ccc(F)cc3)CC2)ccc1CN1CCNCC1	10.1016/j.bmcl.2022.128554
	52950055	17230	0	None	-	1	Rabbit	6.3	pEC50	=	6.3	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction	ChEMBL	780	9	7	15	1.3	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C[C@@H](C)O)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2010.08.030
	CHEMBL1256546	17230	0	None	-	1	Rabbit	6.3	pEC50	=	6.3	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction	ChEMBL	780	9	7	15	1.3	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C[C@@H](C)O)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2010.08.030
	46882753	5720	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	396	4	1	4	3.6	O=S(=O)(Cc1ccc2c(c1)CCNCC2)c1ccc(-c2ccc(F)cc2)nc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1078268	5720	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	396	4	1	4	3.6	O=S(=O)(Cc1ccc2c(c1)CCNCC2)c1ccc(-c2ccc(F)cc2)nc1	10.1016/j.bmcl.2009.09.027
	46882582	5755	0	None	125	2	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	466	5	2	5	3.9	CC1(C)CCc2cc(S(=O)(=O)Nc3ccc4c(c3)CCN(Cc3cc[nH]n3)CC4)ccc2O1	10.1016/j.bmcl.2009.09.027
	CHEMBL1078490	5755	0	None	125	2	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	466	5	2	5	3.9	CC1(C)CCc2cc(S(=O)(=O)Nc3ccc4c(c3)CCN(Cc3cc[nH]n3)CC4)ccc2O1	10.1016/j.bmcl.2009.09.027
	16041121	178289	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	531	7	2	6	4.8	COc1cc(-c2cccnc2C(=O)N2CCC(Nc3ccc(F)cc3)CC2)ccc1CN1C[C@H](C)N[C@H](C)C1	10.1016/j.bmcl.2008.10.072
	CHEMBL465095	178289	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	531	7	2	6	4.8	COc1cc(-c2cccnc2C(=O)N2CCC(Nc3ccc(F)cc3)CC2)ccc1CN1C[C@H](C)N[C@H](C)C1	10.1016/j.bmcl.2008.10.072
	44570491	183060	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	482	6	2	4	5.3	C[C@H]1CN(Cc2ccc(-c3ccccc3C(=O)N3CCC(Nc4ccccc4)CC3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	CHEMBL479419	183060	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	482	6	2	4	5.3	C[C@H]1CN(Cc2ccc(-c3ccccc3C(=O)N3CCC(Nc4ccccc4)CC3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	23729063	88817	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	438	6	1	4	3.5	C[C@H]1CN(Cc2ccc(N(C)C(=O)C3CCN(Cc4cccc(F)c4)CC3)cc2)CCN1	10.6019/CHEMBL2364262
	CHEMBL2364279	88817	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	438	6	1	4	3.5	C[C@H]1CN(Cc2ccc(N(C)C(=O)C3CCN(Cc4cccc(F)c4)CC3)cc2)CCN1	10.6019/CHEMBL2364262
	23729103	88818	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	418	5	1	4	4.0	C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(-c4ccccc4F)nc3)cc2)CCN1	10.6019/CHEMBL2364262
	CHEMBL2364280	88818	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	418	5	1	4	4.0	C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(-c4ccccc4F)nc3)cc2)CCN1	10.6019/CHEMBL2364262
	23728578	88825	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	433	6	1	4	4.7	C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(Oc4ccccc4F)cc3)cc2)CCN1	10.6019/CHEMBL2364262
	CHEMBL2364287	88825	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	433	6	1	4	4.7	C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(Oc4ccccc4F)cc3)cc2)CCN1	10.6019/CHEMBL2364262
	23728582	88827	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	419	5	1	5	3.4	C[C@H]1CN(Cc2ccc(N(C)C(=O)c3cnc(-c4ccc(F)cc4)nc3)cc2)CCN1	10.6019/CHEMBL2364262
	CHEMBL2364289	88827	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	419	5	1	5	3.4	C[C@H]1CN(Cc2ccc(N(C)C(=O)c3cnc(-c4ccc(F)cc4)nc3)cc2)CCN1	10.6019/CHEMBL2364262
	57586303	88828	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	458	6	2	4	3.9	C[C@H]1CN(Cc2ccc(CC(=O)N3CCC(Nc4cccc(F)c4)CC3)cc2Cl)CCN1	10.6019/CHEMBL2364262
	CHEMBL2364290	88828	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	458	6	2	4	3.9	C[C@H]1CN(Cc2ccc(CC(=O)N3CCC(Nc4cccc(F)c4)CC3)cc2Cl)CCN1	10.6019/CHEMBL2364262
	11902	1487	8	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells	ChEMBL	465	7	2	5	3.9	C[C@H]1CN(Cc2ccc(cc2C)N(C)C(=O)[C@H]2CC[C@@H](CC2)Oc2cc(CO)ccc2)CCN1	10.1016/j.bmcl.2022.128554
	56960876	1487	8	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells	ChEMBL	465	7	2	5	3.9	C[C@H]1CN(Cc2ccc(cc2C)N(C)C(=O)[C@H]2CC[C@@H](CC2)Oc2cc(CO)ccc2)CCN1	10.1016/j.bmcl.2022.128554
	CHEMBL5201797	1487	8	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells	ChEMBL	465	7	2	5	3.9	C[C@H]1CN(Cc2ccc(cc2C)N(C)C(=O)[C@H]2CC[C@@H](CC2)Oc2cc(CO)ccc2)CCN1	10.1016/j.bmcl.2022.128554
	89723482	192103	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells	ChEMBL	479	7	2	5	4.2	Cc1cc(N(C)C(=O)[C@H]2CC[C@H](Oc3cc(CO)ccc3C)CC2)ccc1CN1CCN[C@@H](C)C1	10.1016/j.bmcl.2022.128554
	CHEMBL5203126	192103	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells	ChEMBL	479	7	2	5	4.2	Cc1cc(N(C)C(=O)[C@H]2CC[C@H](Oc3cc(CO)ccc3C)CC2)ccc1CN1CCN[C@@H](C)C1	10.1016/j.bmcl.2022.128554
	44542816	198069	0	None	-	1	Rabbit	7.3	pEC50	=	7.3	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	879	14	6	16	2.1	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NCCOC)[C@H](C)[C@@H](O)[C@]1(C)O	10.1021/jm901107f
	CHEMBL574205	198069	0	None	-	1	Rabbit	7.3	pEC50	=	7.3	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	879	14	6	16	2.1	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NCCOC)[C@H](C)[C@@H](O)[C@]1(C)O	10.1021/jm901107f
	1048	1585	76	None	2	4	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1021/jm801332q
	12560	1585	76	None	2	4	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1021/jm801332q
	1456	1585	76	None	2	4	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1021/jm801332q
	CHEMBL532	1585	76	None	2	4	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1021/jm801332q
	DB00199	1585	76	None	2	4	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1021/jm801332q
	15984238	189569	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay	ChEMBL	452	7	2	4	4.0	C[C@H]1CN(Cc2ccc(CCC(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1	10.1021/jm801332q
	CHEMBL514475	189569	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay	ChEMBL	452	7	2	4	4.0	C[C@H]1CN(Cc2ccc(CCC(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1	10.1021/jm801332q
	1048	1585	76	None	2	4	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1016/j.bmcl.2008.10.072
	12560	1585	76	None	2	4	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1016/j.bmcl.2008.10.072
	1456	1585	76	None	2	4	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1016/j.bmcl.2008.10.072
	CHEMBL532	1585	76	None	2	4	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1016/j.bmcl.2008.10.072
	DB00199	1585	76	None	2	4	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1016/j.bmcl.2008.10.072
	46882393	5840	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	511	9	2	5	5.5	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2ccc(NC(C)=O)s2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1079170	5840	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	511	9	2	5	5.5	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2ccc(NC(C)=O)s2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	44571939	180616	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay	ChEMBL	540	10	2	4	5.9	COc1cccc(CCN(Cc2ccccc2-c2ccc(CN3CCNCC3)cc2)C(=O)NC2CCCCC2)c1	10.1016/j.bmcl.2008.10.071
	CHEMBL475467	180616	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay	ChEMBL	540	10	2	4	5.9	COc1cccc(CCN(Cc2ccccc2-c2ccc(CN3CCNCC3)cc2)C(=O)NC2CCCCC2)c1	10.1016/j.bmcl.2008.10.071
	44570409	178414	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	459	7	1	3	4.9	C[C@H]1CN(Cc2ccc(-c3ccccc3CN(C)C(=O)Cc3ccc(F)cc3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	CHEMBL465940	178414	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	459	7	1	3	4.9	C[C@H]1CN(Cc2ccc(-c3ccccc3CN(C)C(=O)Cc3ccc(F)cc3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	44570492	183949	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	516	6	2	4	5.9	C[C@H]1CN(Cc2ccc(-c3ccccc3C(=O)N3CCC(Nc4ccc(Cl)cc4)CC3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	CHEMBL481575	183949	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	516	6	2	4	5.9	C[C@H]1CN(Cc2ccc(-c3ccccc3C(=O)N3CCC(Nc4ccc(Cl)cc4)CC3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	16752689	188368	0	None	5	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	568	10	2	4	6.6	COc1cccc(CCN(Cc2ccccc2-c2ccc(CN3C[C@H](C)N[C@H](C)C3)cc2)C(=O)NC2CCCCC2)c1	10.1016/j.bmcl.2008.10.072
	CHEMBL501315	188368	0	None	5	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	568	10	2	4	6.6	COc1cccc(CCN(Cc2ccccc2-c2ccc(CN3C[C@H](C)N[C@H](C)C3)cc2)C(=O)NC2CCCCC2)c1	10.1016/j.bmcl.2008.10.072
	16041483	190921	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	501	6	2	5	4.8	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccccc4F)CC3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	CHEMBL518540	190921	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	501	6	2	5	4.8	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccccc4F)CC3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	46882671	5634	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	387	4	1	6	1.6	O=S(=O)(Cc1ccc2c(c1)CCNCC2)c1ccc(N2CCOCC2)nc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1077735	5634	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	387	4	1	6	1.6	O=S(=O)(Cc1ccc2c(c1)CCNCC2)c1ccc(N2CCOCC2)nc1	10.1016/j.bmcl.2009.09.027
	46882756	5765	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	412	5	1	5	3.7	O=S(=O)(Cc1ccc2c(c1)CCNCC2)c1ccc(Oc2ccc(F)cc2)nc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1078555	5765	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	412	5	1	5	3.7	O=S(=O)(Cc1ccc2c(c1)CCNCC2)c1ccc(Oc2ccc(F)cc2)nc1	10.1016/j.bmcl.2009.09.027
	46882349	5805	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	505	9	2	4	5.4	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cccc(NC(C)=O)c2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1078881	5805	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	505	9	2	4	5.4	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cccc(NC(C)=O)c2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	44571989	180217	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assay	ChEMBL	478	10	2	4	4.6	COCCCN(Cc1ccccc1-c1ccc(CN2CCNCC2)cc1)C(=O)NC1CCCCC1	10.1016/j.bmcl.2008.10.071
	CHEMBL474978	180217	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assay	ChEMBL	478	10	2	4	4.6	COCCCN(Cc1ccccc1-c1ccc(CN2CCNCC2)cc1)C(=O)NC1CCCCC1	10.1016/j.bmcl.2008.10.071
	44571373	179913	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay	ChEMBL	526	9	2	4	5.9	COc1cccc(CCN(Cc2ccccc2-c2ccc(N3CCNCC3)cc2)C(=O)NC2CCCCC2)c1	10.1016/j.bmcl.2008.10.071
	CHEMBL474606	179913	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay	ChEMBL	526	9	2	4	5.9	COc1cccc(CCN(Cc2ccccc2-c2ccc(N3CCNCC3)cc2)C(=O)NC2CCCCC2)c1	10.1016/j.bmcl.2008.10.071
	44571940	180931	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assay	ChEMBL	415	9	2	4	4.1	COc1cccc(CCNCc2ccccc2-c2ccc(CN3CCNCC3)cc2)c1	10.1016/j.bmcl.2008.10.071
	CHEMBL475808	180931	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assay	ChEMBL	415	9	2	4	4.1	COc1cccc(CCNCc2ccccc2-c2ccc(CN3CCNCC3)cc2)c1	10.1016/j.bmcl.2008.10.071
	11993730	178407	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells	ChEMBL	500	6	1	4	5.2	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Cc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2022.128554
	CHEMBL465925	178407	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells	ChEMBL	500	6	1	4	5.2	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Cc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2022.128554
	44542367	198096	0	None	-	1	Rabbit	6.3	pEC50	=	6.3	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	847	11	6	15	2.3	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C3CCC3)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NC)[C@H](C)[C@@H](O)[C@]1(C)O	10.1021/jm901107f
	CHEMBL574429	198096	0	None	-	1	Rabbit	6.3	pEC50	=	6.3	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	847	11	6	15	2.3	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C3CCC3)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NC)[C@H](C)[C@@H](O)[C@]1(C)O	10.1021/jm901107f
	44542368	198921	0	None	-	1	Rabbit	7.3	pEC50	=	7.3	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	821	11	6	15	1.9	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(N)=O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2011.04.078
	44542368	198921	0	None	-	1	Rabbit	7.3	pEC50	=	7.3	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	821	11	6	15	1.9	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(N)=O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1021/jm901107f
	CHEMBL584550	198921	0	None	-	1	Rabbit	7.3	pEC50	=	7.3	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	821	11	6	15	1.9	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(N)=O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2011.04.078
	CHEMBL584550	198921	0	None	-	1	Rabbit	7.3	pEC50	=	7.3	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	821	11	6	15	1.9	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(N)=O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1021/jm901107f
	56960873	191716	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells	ChEMBL	439	6	1	4	4.2	C[C@H]1CN(Cc2ccc(N(C)C(=O)[C@H]3CC[C@H](Oc4ccc(F)cc4)CC3)cc2)CCN1	10.1016/j.bmcl.2022.128554
	CHEMBL5197045	191716	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells	ChEMBL	439	6	1	4	4.2	C[C@H]1CN(Cc2ccc(N(C)C(=O)[C@H]3CC[C@H](Oc4ccc(F)cc4)CC3)cc2)CCN1	10.1016/j.bmcl.2022.128554
	11398860	176045	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	In vitro effective concentration towards human motilin receptorIn vitro effective concentration towards human motilin receptor	ChEMBL	560	8	3	10	0.4	NC(=O)[C@H](CCc1ccccc1)NC(=O)C1C=CC2(CCNCC2)n2c(=O)n(Cc3ccc4c(c3)OCO4)c(=O)n21	10.1021/jm0304865
	CHEMBL45905	176045	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	In vitro effective concentration towards human motilin receptorIn vitro effective concentration towards human motilin receptor	ChEMBL	560	8	3	10	0.4	NC(=O)[C@H](CCc1ccccc1)NC(=O)C1C=CC2(CCNCC2)n2c(=O)n(Cc3ccc4c(c3)OCO4)c(=O)n21	10.1021/jm0304865
	52947633	17225	0	None	-	1	Rabbit	5.2	pEC50	=	5.2	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction	ChEMBL	777	8	6	15	1.3	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C3COC3)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2010.08.030
	CHEMBL1256540	17225	0	None	-	1	Rabbit	5.2	pEC50	=	5.2	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction	ChEMBL	777	8	6	15	1.3	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C3COC3)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2010.08.030
	45483679	197918	0	None	-	1	Rabbit	7.2	pEC50	=	7.2	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	835	11	6	15	2.1	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NC)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2011.04.078
	45483679	197918	0	None	-	1	Rabbit	7.2	pEC50	=	7.2	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	835	11	6	15	2.1	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NC)[C@H](C)[C@@H](O)[C@]1(C)O	10.1021/jm901107f
	CHEMBL572996	197918	0	None	-	1	Rabbit	7.2	pEC50	=	7.2	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	835	11	6	15	2.1	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NC)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2011.04.078
	CHEMBL572996	197918	0	None	-	1	Rabbit	7.2	pEC50	=	7.2	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	835	11	6	15	2.1	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NC)[C@H](C)[C@@H](O)[C@]1(C)O	10.1021/jm901107f
	54584601	62210	0	None	-	1	Rabbit	7.2	pEC50	=	7.2	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	748	8	5	13	3.4	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2011.04.078
	CHEMBL1778045	62210	0	None	-	1	Rabbit	7.2	pEC50	=	7.2	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	748	8	5	13	3.4	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2011.04.078
	45102708	5770	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	468	6	2	7	2.0	O=S(=O)(Nc1ccc2c(c1)CCN(Cc1cc[nH]n1)CC2)c1ccc(N2CCOCC2)nc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1078595	5770	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	468	6	2	7	2.0	O=S(=O)(Nc1ccc2c(c1)CCN(Cc1cc[nH]n1)CC2)c1ccc(N2CCOCC2)nc1	10.1016/j.bmcl.2009.09.027
	16040940	177450	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	501	6	2	5	4.8	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4cccc(F)c4)CC3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	CHEMBL463881	177450	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	501	6	2	5	4.8	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4cccc(F)c4)CC3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	15984999	88807	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	474	6	2	4	4.1	C[C@H]1CN(Cc2ccc(CC(=O)N3CCC(Nc4cccc(C(F)(F)F)c4)CC3)cc2)CCN1	10.6019/CHEMBL2364262
	CHEMBL2364269	88807	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	474	6	2	4	4.1	C[C@H]1CN(Cc2ccc(CC(=O)N3CCC(Nc4cccc(C(F)(F)F)c4)CC3)cc2)CCN1	10.6019/CHEMBL2364262
	23728692	88834	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	436	5	1	4	4.1	C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(-c4cccc(F)c4)nc3)c(F)c2)CCN1	10.6019/CHEMBL2364262
	CHEMBL2364296	88834	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	436	5	1	4	4.1	C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(-c4cccc(F)c4)nc3)c(F)c2)CCN1	10.6019/CHEMBL2364262
	16749781	88866	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	464	6	1	7	3.6	C[C@H]1CN(Cc2ccn(-c3cccnc3N3CCC(Oc4ccccc4F)CC3)n2)C[C@@H](C)N1	10.6019/CHEMBL2364262
	CHEMBL2364327	88866	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	464	6	1	7	3.6	C[C@H]1CN(Cc2ccn(-c3cccnc3N3CCC(Oc4ccccc4F)CC3)n2)C[C@@H](C)N1	10.6019/CHEMBL2364262
	54582661	62212	0	None	-	1	Rabbit	7.2	pEC50	=	7.2	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	749	9	6	14	2.0	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCO)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2011.04.078
	CHEMBL1778047	62212	0	None	-	1	Rabbit	7.2	pEC50	=	7.2	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	749	9	6	14	2.0	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCO)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2011.04.078
	15984240	179522	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay	ChEMBL	438	7	2	4	3.7	C[C@H]1CN(Cc2ccc(CCC(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)CCN1	10.1021/jm801332q
	CHEMBL474129	179522	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay	ChEMBL	438	7	2	4	3.7	C[C@H]1CN(Cc2ccc(CCC(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)CCN1	10.1021/jm801332q
	46882796	5750	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	385	4	1	5	2.7	O=S(=O)(Cc1ccc2c(c1)CCNCC2)c1ccc(N2CCCCC2)nc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1078463	5750	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	385	4	1	5	2.7	O=S(=O)(Cc1ccc2c(c1)CCNCC2)c1ccc(N2CCCCC2)nc1	10.1016/j.bmcl.2009.09.027
	46882396	5844	0	None	-3	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	452	8	2	4	4.5	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cnc(C)[nH]2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1079187	5844	0	None	-3	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	452	8	2	4	4.5	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cnc(C)[nH]2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	44570528	183606	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	513	6	1	4	5.4	C[C@H]1CN(Cc2ccc(-c3ccccc3C(=O)N3CCC(C(=O)c4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	CHEMBL480210	183606	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	513	6	1	4	5.4	C[C@H]1CN(Cc2ccc(-c3ccccc3C(=O)N3CCC(C(=O)c4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	44570490	190647	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	501	6	1	4	5.4	C[C@H]1CN(Cc2ccc(-c3ccccc3C(=O)N3CCC(Oc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	CHEMBL518142	190647	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	501	6	1	4	5.4	C[C@H]1CN(Cc2ccc(-c3ccccc3C(=O)N3CCC(Oc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	23728734	88843	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	445	6	1	5	3.2	C[C@H]1CN(Cc2ccc(N(C)C(=O)C3CCN(Cc4ccc(C#N)cc4)CC3)cc2)CCN1	10.6019/CHEMBL2364262
	CHEMBL2364305	88843	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	445	6	1	5	3.2	C[C@H]1CN(Cc2ccc(N(C)C(=O)C3CCN(Cc4ccc(C#N)cc4)CC3)cc2)CCN1	10.6019/CHEMBL2364262
	1048	1585	76	None	2	4	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1016/j.bmcl.2008.10.072
	12560	1585	76	None	2	4	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1016/j.bmcl.2008.10.072
	1456	1585	76	None	2	4	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1016/j.bmcl.2008.10.072
	CHEMBL532	1585	76	None	2	4	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1016/j.bmcl.2008.10.072
	DB00199	1585	76	None	2	4	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1016/j.bmcl.2008.10.072
	44569919	178804	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	508	6	2	6	4.5	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(C#N)cc4)CC3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	CHEMBL469097	178804	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	508	6	2	6	4.5	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(C#N)cc4)CC3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	44572029	179406	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assay	ChEMBL	511	11	1	5	4.1	COCCCN(Cc1ccccc1-c1ccc(CN2CCNCC2)cc1)S(=O)(=O)c1ccc(F)cc1	10.1016/j.bmcl.2008.10.071
	CHEMBL474008	179406	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assay	ChEMBL	511	11	1	5	4.1	COCCCN(Cc1ccccc1-c1ccc(CN2CCNCC2)cc1)S(=O)(=O)c1ccc(F)cc1	10.1016/j.bmcl.2008.10.071
	44571991	180945	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assay	ChEMBL	395	9	1	4	3.1	COCCCN(Cc1ccccc1-c1ccc(CN2CCNCC2)cc1)C(C)=O	10.1016/j.bmcl.2008.10.071
	CHEMBL475823	180945	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by calcium mobilization-based FLIPR assay	ChEMBL	395	9	1	4	3.1	COCCCN(Cc1ccccc1-c1ccc(CN2CCNCC2)cc1)C(C)=O	10.1016/j.bmcl.2008.10.071
	44542369	198922	0	None	-	1	Rabbit	6.2	pEC50	=	6.2	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	849	11	5	15	2.5	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)N(C)C)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2011.04.078
	44542369	198922	0	None	-	1	Rabbit	6.2	pEC50	=	6.2	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	849	11	5	15	2.5	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)N(C)C)[C@H](C)[C@@H](O)[C@]1(C)O	10.1021/jm901107f
	CHEMBL584551	198922	0	None	-	1	Rabbit	6.2	pEC50	=	6.2	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	849	11	5	15	2.5	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)N(C)C)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2011.04.078
	CHEMBL584551	198922	0	None	-	1	Rabbit	6.2	pEC50	=	6.2	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	849	11	5	15	2.5	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)N(C)C)[C@H](C)[C@@H](O)[C@]1(C)O	10.1021/jm901107f
	44541928	198923	0	None	-	1	Rabbit	7.2	pEC50	=	7.2	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	849	12	6	15	2.5	CCNC(=O)CO[C@H]1[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@H]1C	10.1021/jm901107f
	CHEMBL584552	198923	0	None	-	1	Rabbit	7.2	pEC50	=	7.2	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	849	12	6	15	2.5	CCNC(=O)CO[C@H]1[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@H]1C	10.1021/jm901107f
	44542069	197919	0	None	-	1	Rabbit	7.2	pEC50	=	7.2	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	899	12	6	17	2.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)Nc2cnccn2)[C@H](C)[C@@H](O)[C@]1(C)O	10.1021/jm901107f
	CHEMBL572997	197919	0	None	-	1	Rabbit	7.2	pEC50	=	7.2	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	899	12	6	17	2.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)Nc2cnccn2)[C@H](C)[C@@H](O)[C@]1(C)O	10.1021/jm901107f
	53322109	56269	0	None	-1	2	Rabbit	8.2	pEC50	=	8.2	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction	ChEMBL	697	8	2	11	5.2	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@H]1C	10.1016/j.bmcl.2010.08.030
	CHEMBL1628277	56269	0	None	-1	2	Rabbit	8.2	pEC50	=	8.2	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction	ChEMBL	697	8	2	11	5.2	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@H]1C	10.1016/j.bmcl.2010.08.030
	53322109	56269	0	None	-1	2	Rabbit	8.2	pEC50	=	8.2	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	697	8	2	11	5.2	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@H]1C	10.1016/j.bmcl.2011.04.078
	53322109	56269	0	None	-1	2	Rabbit	8.2	pEC50	=	8.2	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	697	8	2	11	5.2	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@H]1C	10.1021/jm901107f
	CHEMBL1628277	56269	0	None	-1	2	Rabbit	8.2	pEC50	=	8.2	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	697	8	2	11	5.2	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@H]1C	10.1016/j.bmcl.2011.04.078
	CHEMBL1628277	56269	0	None	-1	2	Rabbit	8.2	pEC50	=	8.2	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	697	8	2	11	5.2	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@H]1C	10.1021/jm901107f
	44292517	101531	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	In vitro effective concentration towards human motilin receptorIn vitro effective concentration towards human motilin receptor	ChEMBL	723	13	4	11	1.7	NC(=O)[C@@H](CCc1ccccc1)NC(=O)[C@@H](CCc1ccccc1)NC(=O)C1CCC2(CCNCC2)n2c(=O)n(Cc3ccc4c(c3)OCO4)c(=O)n21	10.1021/jm0304865
	CHEMBL298224	101531	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	In vitro effective concentration towards human motilin receptorIn vitro effective concentration towards human motilin receptor	ChEMBL	723	13	4	11	1.7	NC(=O)[C@@H](CCc1ccccc1)NC(=O)[C@@H](CCc1ccccc1)NC(=O)C1CCC2(CCNCC2)n2c(=O)n(Cc3ccc4c(c3)OCO4)c(=O)n21	10.1021/jm0304865
	89723612	191288	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells	ChEMBL	483	7	2	5	4.0	Cc1cc(N(C)C(=O)[C@H]2CC[C@H](Oc3ccc(F)c(CO)c3)CC2)ccc1CN1CCN[C@@H](C)C1	10.1016/j.bmcl.2022.128554
	CHEMBL5190786	191288	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells	ChEMBL	483	7	2	5	4.0	Cc1cc(N(C)C(=O)[C@H]2CC[C@H](Oc3ccc(F)c(CO)c3)CC2)ccc1CN1CCN[C@@H](C)C1	10.1016/j.bmcl.2022.128554
	46882752	5719	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	412	4	1	4	4.1	O=S(=O)(Cc1ccc2c(c1)CCNCC2)c1ccc(-c2ccc(Cl)cc2)nc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1078267	5719	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	412	4	1	4	4.1	O=S(=O)(Cc1ccc2c(c1)CCNCC2)c1ccc(-c2ccc(Cl)cc2)nc1	10.1016/j.bmcl.2009.09.027
	45102707	5757	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	465	6	2	6	3.9	O=S(=O)(Nc1ccc2c(c1)CCN(Cc1cc[nH]n1)CC2)c1ccc(-c2ccccn2)s1	10.1016/j.bmcl.2009.09.027
	CHEMBL1078492	5757	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	465	6	2	6	3.9	O=S(=O)(Nc1ccc2c(c1)CCN(Cc1cc[nH]n1)CC2)c1ccc(-c2ccccn2)s1	10.1016/j.bmcl.2009.09.027
	46882394	5842	0	None	-1	2	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	438	8	2	4	4.2	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cnc[nH]2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1079185	5842	0	None	-1	2	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	438	8	2	4	4.2	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cnc[nH]2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	44570453	178374	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	455	8	1	3	5.2	CCN(CCc1ccccc1)C(=O)c1ccccc1-c1ccc(CN2C[C@H](C)N[C@H](C)C2)cc1	10.1016/j.bmcl.2008.10.072
	CHEMBL465289	178374	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	455	8	1	3	5.2	CCN(CCc1ccccc1)C(=O)c1ccccc1-c1ccc(CN2C[C@H](C)N[C@H](C)C2)cc1	10.1016/j.bmcl.2008.10.072
	15984995	88803	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	442	6	2	4	3.4	C[C@H]1CN(Cc2ccc(CC(=O)N3CCC(Nc4ccc(F)c(F)c4)CC3)cc2)CCN1	10.6019/CHEMBL2364262
	CHEMBL2364265	88803	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	442	6	2	4	3.4	C[C@H]1CN(Cc2ccc(CC(=O)N3CCC(Nc4ccc(F)c(F)c4)CC3)cc2)CCN1	10.6019/CHEMBL2364262
	23728626	88829	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	434	6	1	5	4.1	C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(Oc4ccccc4F)nc3)cc2)CCN1	10.6019/CHEMBL2364262
	CHEMBL2364291	88829	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	434	6	1	5	4.1	C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(Oc4ccccc4F)nc3)cc2)CCN1	10.6019/CHEMBL2364262
	23728691	88832	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	425	5	1	5	3.7	C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(-c4cccc(C#N)c4)nc3)cc2)CCN1	10.6019/CHEMBL2364262
	CHEMBL2364294	88832	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	425	5	1	5	3.7	C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(-c4cccc(C#N)c4)nc3)cc2)CCN1	10.6019/CHEMBL2364262
	23728730	88838	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	438	6	1	4	3.5	C[C@H]1CN(Cc2ccc(N(C)C(=O)C3CCN(Cc4ccc(F)cc4)CC3)cc2)CCN1	10.6019/CHEMBL2364262
	CHEMBL2364300	88838	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	438	6	1	4	3.5	C[C@H]1CN(Cc2ccc(N(C)C(=O)C3CCN(Cc4ccc(F)cc4)CC3)cc2)CCN1	10.6019/CHEMBL2364262
	23728871	88844	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	418	5	1	4	4.0	C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(-c4cccc(F)c4)cn3)cc2)CCN1	10.6019/CHEMBL2364262
	CHEMBL2364306	88844	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	418	5	1	4	4.0	C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(-c4cccc(F)c4)cn3)cc2)CCN1	10.6019/CHEMBL2364262
	23728838	88845	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	418	5	1	4	4.0	C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(-c4ccc(F)cc4)cn3)cc2)CCN1	10.6019/CHEMBL2364262
	CHEMBL2364307	88845	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	418	5	1	4	4.0	C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(-c4ccc(F)cc4)cn3)cc2)CCN1	10.6019/CHEMBL2364262
	23728841	88850	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	430	6	1	5	3.8	COc1cccc(-c2ccc(C(=O)N(C)c3ccc(CN4CCN[C@@H](C)C4)cc3)nc2)c1	10.6019/CHEMBL2364262
	CHEMBL2364311	88850	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	430	6	1	5	3.8	COc1cccc(-c2ccc(C(=O)N(C)c3ccc(CN4CCN[C@@H](C)C4)cc3)nc2)c1	10.6019/CHEMBL2364262
	52946409	17228	0	None	-	1	Rabbit	6.2	pEC50	=	6.2	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction	ChEMBL	780	10	7	15	1.3	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCCO)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2010.08.030
	CHEMBL1256544	17228	0	None	-	1	Rabbit	6.2	pEC50	=	6.2	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction	ChEMBL	780	10	7	15	1.3	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCCO)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2010.08.030
	52945184	17234	0	None	-	1	Rabbit	5.1	pEC50	=	5.1	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction	ChEMBL	765	9	7	15	0.9	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCN)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2010.08.030
	CHEMBL1256550	17234	0	None	-	1	Rabbit	5.1	pEC50	=	5.1	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction	ChEMBL	765	9	7	15	0.9	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCN)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2010.08.030
	52950054	17227	0	None	-	1	Rabbit	5.1	pEC50	=	5.1	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction	ChEMBL	780	10	6	15	1.6	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCOC)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2010.08.030
	CHEMBL1256543	17227	0	None	-	1	Rabbit	5.1	pEC50	=	5.1	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction	ChEMBL	780	10	6	15	1.6	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CCOC)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/j.bmcl.2010.08.030
	44542817	198735	0	None	-	1	Rabbit	7.1	pEC50	=	7.1	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	911	13	6	15	3.7	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O	10.1021/jm901107f
	CHEMBL582873	198735	0	None	-	1	Rabbit	7.1	pEC50	=	7.1	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	911	13	6	15	3.7	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NCc2ccccc2)[C@H](C)[C@@H](O)[C@]1(C)O	10.1021/jm901107f
	44570364	178360	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	457	8	1	4	4.6	C[C@H]1CN(Cc2ccc(-c3ccccc3CN(C)C(=O)COc3ccccc3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	CHEMBL465244	178360	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	457	8	1	4	4.6	C[C@H]1CN(Cc2ccc(-c3ccccc3CN(C)C(=O)COc3ccccc3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	44570410	178415	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	475	7	1	3	5.4	C[C@H]1CN(Cc2ccc(-c3ccccc3CN(C)C(=O)Cc3cccc(Cl)c3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	CHEMBL465941	178415	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	475	7	1	3	5.4	C[C@H]1CN(Cc2ccc(-c3ccccc3CN(C)C(=O)Cc3cccc(Cl)c3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	23728916	88858	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	425	5	1	5	3.1	C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(N4CCC(F)CC4)nc3)cc2)CCN1	10.6019/CHEMBL2364262
	CHEMBL2364319	88858	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680SUPPLEMENTARY: Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay. Same assay as CHEMBL942680	ChEMBL	425	5	1	5	3.1	C[C@H]1CN(Cc2ccc(N(C)C(=O)c3ccc(N4CCC(F)CC4)nc3)cc2)CCN1	10.6019/CHEMBL2364262
	46882519	5707	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	416	5	2	4	3.5	O=S(=O)(Nc1ccc2c(c1)CCN(Cc1cc[nH]n1)CC2)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1078104	5707	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	416	5	2	4	3.5	O=S(=O)(Nc1ccc2c(c1)CCN(Cc1cc[nH]n1)CC2)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.09.027
	44572030	179416	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay	ChEMBL	471	11	1	4	4.4	COCCCN(Cc1ccccc1-c1ccc(CN2CCNCC2)cc1)C(=O)Cc1ccccc1	10.1016/j.bmcl.2008.10.071
	CHEMBL474018	179416	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assay	ChEMBL	471	11	1	4	4.4	COCCCN(Cc1ccccc1-c1ccc(CN2CCNCC2)cc1)C(=O)Cc1ccccc1	10.1016/j.bmcl.2008.10.071
	44569920	189413	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	508	6	2	6	4.5	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccccc4C#N)CC3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	CHEMBL513183	189413	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL	508	6	2	6	4.5	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccccc4C#N)CC3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	46882461	6312	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	407	5	2	5	2.7	N#Cc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cc[nH]n2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1081860	6312	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayAgonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay	ChEMBL	407	5	2	5	2.7	N#Cc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cc[nH]n2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	44542214	198767	0	None	-	1	Rabbit	7.1	pEC50	=	7.1	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	863	13	6	15	2.9	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCCCC(=O)NC)[C@H](C)[C@@H](O)[C@]1(C)O	10.1021/jm901107f
	CHEMBL583095	198767	0	None	-	1	Rabbit	7.1	pEC50	=	7.1	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	863	13	6	15	2.9	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCCCC(=O)NC)[C@H](C)[C@@H](O)[C@]1(C)O	10.1021/jm901107f
	44542666	198770	0	None	-	1	Rabbit	7.1	pEC50	=	7.1	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	819	11	5	14	3.0	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NC)[C@H](C)[C@@H](O)[C@H]1C	10.1021/jm901107f
	CHEMBL583098	198770	0	None	-	1	Rabbit	7.1	pEC50	=	7.1	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	819	11	5	14	3.0	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NC)[C@H](C)[C@@H](O)[C@H]1C	10.1021/jm901107f
	44542815	198244	0	None	-	1	Rabbit	7.0	pEC50	=	7.0	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	851	12	6	16	2.1	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NOC)[C@H](C)[C@@H](O)[C@]1(C)O	10.1021/jm901107f
	CHEMBL575518	198244	0	None	-	1	Rabbit	7.0	pEC50	=	7.0	Functional	Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contractionAgonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction	ChEMBL	851	12	6	16	2.1	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NOC)[C@H](C)[C@@H](O)[C@]1(C)O	10.1021/jm901107f
	15984937	785	31	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells	ChEMBL	424	6	2	4	3.3	C[C@@H]1NCCN(C1)Cc1ccc(cc1)CC(=O)N1CCC(CC1)Nc1cccc(c1)F	10.1016/j.bmcl.2022.128554
	4035	785	31	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells	ChEMBL	424	6	2	4	3.3	C[C@@H]1NCCN(C1)Cc1ccc(cc1)CC(=O)N1CCC(CC1)Nc1cccc(c1)F	10.1016/j.bmcl.2022.128554
	CHEMBL489095	785	31	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells	ChEMBL	424	6	2	4	3.3	C[C@@H]1NCCN(C1)Cc1ccc(cc1)CC(=O)N1CCC(CC1)Nc1cccc(c1)F	10.1016/j.bmcl.2022.128554
	DB12567	785	31	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR38 expressed in COS-7 cellsAgonist activity at human GPR38 expressed in COS-7 cells	ChEMBL	424	6	2	4	3.3	C[C@@H]1NCCN(C1)Cc1ccc(cc1)CC(=O)N1CCC(CC1)Nc1cccc(c1)F	10.1016/j.bmcl.2022.128554
	23656869	147856	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assayAntagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assay	ChEMBL	631	5	4	6	3.1	CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(C(F)(F)F)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CN2CCCC2)NC1=O	10.1016/j.bmcl.2007.05.043
	CHEMBL393315	147856	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assayAntagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assay	ChEMBL	631	5	4	6	3.1	CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(C(F)(F)F)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CN2CCCC2)NC1=O	10.1016/j.bmcl.2007.05.043
	23557214	141083	0	None	6	2	Rabbit	7.7	pIC50	=	7.7	Functional	Activity at rabbit duodenum motilin receptor by tissue contractility assayActivity at rabbit duodenum motilin receptor by tissue contractility assay	ChEMBL	721	11	0	4	8.9	O=C(c1ccc(F)cc1)N(CC1CCCC(N(Cc2cccc(Cl)c2)C(=O)C(Cl)(Cl)Cl)C1)c1cccc(OCCN2CCCCC2)c1	10.1016/j.bmcl.2006.04.017
	CHEMBL382613	141083	0	None	6	2	Rabbit	7.7	pIC50	=	7.7	Functional	Activity at rabbit duodenum motilin receptor by tissue contractility assayActivity at rabbit duodenum motilin receptor by tissue contractility assay	ChEMBL	721	11	0	4	8.9	O=C(c1ccc(F)cc1)N(CC1CCCC(N(Cc2cccc(Cl)c2)C(=O)C(Cl)(Cl)Cl)C1)c1cccc(OCCN2CCCCC2)c1	10.1016/j.bmcl.2006.04.017
	23557214	141083	0	None	-6	2	Human	6.6	pIC50	=	6.6	Functional	Activity at human motilin receptor transfected in HEK293 cells assessed as inhibition of motilin-induced intracellular calcium mobilizationActivity at human motilin receptor transfected in HEK293 cells assessed as inhibition of motilin-induced intracellular calcium mobilization	ChEMBL	721	11	0	4	8.9	O=C(c1ccc(F)cc1)N(CC1CCCC(N(Cc2cccc(Cl)c2)C(=O)C(Cl)(Cl)Cl)C1)c1cccc(OCCN2CCCCC2)c1	10.1016/j.bmcl.2006.04.017
	CHEMBL382613	141083	0	None	-6	2	Human	6.6	pIC50	=	6.6	Functional	Activity at human motilin receptor transfected in HEK293 cells assessed as inhibition of motilin-induced intracellular calcium mobilizationActivity at human motilin receptor transfected in HEK293 cells assessed as inhibition of motilin-induced intracellular calcium mobilization	ChEMBL	721	11	0	4	8.9	O=C(c1ccc(F)cc1)N(CC1CCCC(N(Cc2cccc(Cl)c2)C(=O)C(Cl)(Cl)Cl)C1)c1cccc(OCCN2CCCCC2)c1	10.1016/j.bmcl.2006.04.017
	11341873	141504	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Activity at human MOTR expressed in CHO cells assessed as inhibition of motilin-induced calcium releaseActivity at human MOTR expressed in CHO cells assessed as inhibition of motilin-induced calcium release	ChEMBL	552	6	4	6	2.8	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(OC)cc2)NCCOc2ccccc2CCCNC1=O	10.1021/jm0606600
	CHEMBL384501	141504	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Activity at human MOTR expressed in CHO cells assessed as inhibition of motilin-induced calcium releaseActivity at human MOTR expressed in CHO cells assessed as inhibition of motilin-induced calcium release	ChEMBL	552	6	4	6	2.8	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(OC)cc2)NCCOc2ccccc2CCCNC1=O	10.1021/jm0606600
	23557218	139556	0	None	38	2	Rabbit	7.6	pIC50	=	7.6	Functional	Activity at rabbit duodenum motilin receptor by tissue contractility assayActivity at rabbit duodenum motilin receptor by tissue contractility assay	ChEMBL	613	11	0	4	7.6	CC(C)(C)C(=O)N(Cc1ccccc1)C1CCCC(CN(C(=O)c2ccc(F)cc2)c2cccc(OCCN3CCCC3)c2)C1	10.1016/j.bmcl.2006.04.017
	CHEMBL379665	139556	0	None	38	2	Rabbit	7.6	pIC50	=	7.6	Functional	Activity at rabbit duodenum motilin receptor by tissue contractility assayActivity at rabbit duodenum motilin receptor by tissue contractility assay	ChEMBL	613	11	0	4	7.6	CC(C)(C)C(=O)N(Cc1ccccc1)C1CCCC(CN(C(=O)c2ccc(F)cc2)c2cccc(OCCN3CCCC3)c2)C1	10.1016/j.bmcl.2006.04.017
	12016400	168960	0	None	-11	2	Human	5.6	pIC50	=	5.6	Functional	Activity at human motilin receptor transfected in HEK293 cells assessed as inhibition of motilin-induced intracellular calcium mobilizationActivity at human motilin receptor transfected in HEK293 cells assessed as inhibition of motilin-induced intracellular calcium mobilization	ChEMBL	613	11	0	4	7.6	CC(C)(C)C(=O)N(Cc1ccccc1)[C@H]1CCC[C@@H](CN(C(=O)c2ccc(F)cc2)c2cccc(OCCN3CCCC3)c2)C1	10.1016/j.bmcl.2006.04.017
	CHEMBL438962	168960	0	None	-11	2	Human	5.6	pIC50	=	5.6	Functional	Activity at human motilin receptor transfected in HEK293 cells assessed as inhibition of motilin-induced intracellular calcium mobilizationActivity at human motilin receptor transfected in HEK293 cells assessed as inhibition of motilin-induced intracellular calcium mobilization	ChEMBL	613	11	0	4	7.6	CC(C)(C)C(=O)N(Cc1ccccc1)[C@H]1CCC[C@@H](CN(C(=O)c2ccc(F)cc2)c2cccc(OCCN3CCCC3)c2)C1	10.1016/j.bmcl.2006.04.017
	44412878	141082	0	None	-5	2	Human	6.6	pIC50	=	6.6	Functional	Activity at human motilin receptor transfected in HEK293 cells assessed as inhibition of motilin-induced intracellular calcium mobilizationActivity at human motilin receptor transfected in HEK293 cells assessed as inhibition of motilin-induced intracellular calcium mobilization	ChEMBL	707	11	0	4	8.6	O=C(c1ccc(F)cc1)N(CC1CCCC(N(Cc2cccc(Cl)c2)C(=O)C(Cl)(Cl)Cl)C1)c1cccc(OCCN2CCCC2)c1	10.1016/j.bmcl.2006.04.017
	CHEMBL382612	141082	0	None	-5	2	Human	6.6	pIC50	=	6.6	Functional	Activity at human motilin receptor transfected in HEK293 cells assessed as inhibition of motilin-induced intracellular calcium mobilizationActivity at human motilin receptor transfected in HEK293 cells assessed as inhibition of motilin-induced intracellular calcium mobilization	ChEMBL	707	11	0	4	8.6	O=C(c1ccc(F)cc1)N(CC1CCCC(N(Cc2cccc(Cl)c2)C(=O)C(Cl)(Cl)Cl)C1)c1cccc(OCCN2CCCC2)c1	10.1016/j.bmcl.2006.04.017
	44412861	77874	0	None	-	1	Rabbit	7.6	pIC50	=	7.6	Functional	Activity at rabbit duodenum motilin receptor by tissue contractility assayActivity at rabbit duodenum motilin receptor by tissue contractility assay	ChEMBL	673	11	0	4	7.9	O=C(c1ccc(F)cc1)N(CC1CCCC(N(Cc2ccccc2)C(=O)C(Cl)(Cl)Cl)C1)c1cccc(OCCN2CCCC2)c1	10.1016/j.bmcl.2006.04.017
	CHEMBL209333	77874	0	None	-	1	Rabbit	7.6	pIC50	=	7.6	Functional	Activity at rabbit duodenum motilin receptor by tissue contractility assayActivity at rabbit duodenum motilin receptor by tissue contractility assay	ChEMBL	673	11	0	4	7.9	O=C(c1ccc(F)cc1)N(CC1CCCC(N(Cc2ccccc2)C(=O)C(Cl)(Cl)Cl)C1)c1cccc(OCCN2CCCC2)c1	10.1016/j.bmcl.2006.04.017
	44432977	151680	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assayAntagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assay	ChEMBL	619	5	7	6	1.5	CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(C(F)(F)F)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CNC(=N)N)NC1=O	10.1016/j.bmcl.2007.05.043
	CHEMBL396413	151680	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assayAntagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assay	ChEMBL	619	5	7	6	1.5	CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(C(F)(F)F)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CNC(=N)N)NC1=O	10.1016/j.bmcl.2007.05.043
	44432975	87740	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assayAntagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assay	ChEMBL	591	5	5	6	2.2	CNC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2cccc(C(F)(F)F)c2)NCCOc2ccccc2CCCNC1=O	10.1016/j.bmcl.2007.05.043
	CHEMBL233711	87740	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assayAntagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assay	ChEMBL	591	5	5	6	2.2	CNC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2cccc(C(F)(F)F)c2)NCCOc2ccccc2CCCNC1=O	10.1016/j.bmcl.2007.05.043
	44432974	87564	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assayAntagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assay	ChEMBL	557	5	5	6	1.8	CNC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NCCOc2ccccc2CCCNC1=O	10.1016/j.bmcl.2007.05.043
	CHEMBL233560	87564	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assayAntagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assay	ChEMBL	557	5	5	6	1.8	CNC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NCCOc2ccccc2CCCNC1=O	10.1016/j.bmcl.2007.05.043
	9895192	77855	0	None	-38	2	Human	6.5	pIC50	=	6.5	Functional	Activity at human motilin receptor transfected in HEK293 cells assessed as inhibition of motilin-induced intracellular calcium mobilizationActivity at human motilin receptor transfected in HEK293 cells assessed as inhibition of motilin-induced intracellular calcium mobilization	ChEMBL	613	11	0	4	7.6	CC(C)(C)C(=O)N(Cc1ccccc1)[C@@H]1CCC[C@H](CN(C(=O)c2ccc(F)cc2)c2cccc(OCCN3CCCC3)c2)C1	10.1016/j.bmcl.2006.04.017
	CHEMBL209301	77855	0	None	-38	2	Human	6.5	pIC50	=	6.5	Functional	Activity at human motilin receptor transfected in HEK293 cells assessed as inhibition of motilin-induced intracellular calcium mobilizationActivity at human motilin receptor transfected in HEK293 cells assessed as inhibition of motilin-induced intracellular calcium mobilization	ChEMBL	613	11	0	4	7.6	CC(C)(C)C(=O)N(Cc1ccccc1)[C@@H]1CCC[C@H](CN(C(=O)c2ccc(F)cc2)c2cccc(OCCN3CCCC3)c2)C1	10.1016/j.bmcl.2006.04.017
	44412878	141082	0	None	5	2	Rabbit	7.4	pIC50	=	7.4	Functional	Activity at rabbit duodenum motilin receptor by tissue contractility assayActivity at rabbit duodenum motilin receptor by tissue contractility assay	ChEMBL	707	11	0	4	8.6	O=C(c1ccc(F)cc1)N(CC1CCCC(N(Cc2cccc(Cl)c2)C(=O)C(Cl)(Cl)Cl)C1)c1cccc(OCCN2CCCC2)c1	10.1016/j.bmcl.2006.04.017
	CHEMBL382612	141082	0	None	5	2	Rabbit	7.4	pIC50	=	7.4	Functional	Activity at rabbit duodenum motilin receptor by tissue contractility assayActivity at rabbit duodenum motilin receptor by tissue contractility assay	ChEMBL	707	11	0	4	8.6	O=C(c1ccc(F)cc1)N(CC1CCCC(N(Cc2cccc(Cl)c2)C(=O)C(Cl)(Cl)Cl)C1)c1cccc(OCCN2CCCC2)c1	10.1016/j.bmcl.2006.04.017
	44412894	138910	0	None	-1	2	Human	7.3	pIC50	=	7.3	Functional	Activity at human motilin receptor transfected in HEK293 cells assessed as inhibition of motilin-induced intracellular calcium mobilizationActivity at human motilin receptor transfected in HEK293 cells assessed as inhibition of motilin-induced intracellular calcium mobilization	ChEMBL	718	12	0	6	7.8	O=C(c1ccc(F)cc1)N(CC1CCCC(N(Cc2cccc([N+](=O)[O-])c2)C(=O)C(Cl)(Cl)Cl)C1)c1cccc(OCCN2CCCC2)c1	10.1016/j.bmcl.2006.04.017
	CHEMBL378317	138910	0	None	-1	2	Human	7.3	pIC50	=	7.3	Functional	Activity at human motilin receptor transfected in HEK293 cells assessed as inhibition of motilin-induced intracellular calcium mobilizationActivity at human motilin receptor transfected in HEK293 cells assessed as inhibition of motilin-induced intracellular calcium mobilization	ChEMBL	718	12	0	6	7.8	O=C(c1ccc(F)cc1)N(CC1CCCC(N(Cc2cccc([N+](=O)[O-])c2)C(=O)C(Cl)(Cl)Cl)C1)c1cccc(OCCN2CCCC2)c1	10.1016/j.bmcl.2006.04.017
	25114977	147009	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assayAntagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assay	ChEMBL	594	5	4	7	2.5	CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(Cl)c2)NCCOc2ccccc2CCCNC(=O)[C@H](Cn2cccn2)NC1=O	10.1016/j.bmcl.2007.05.043
	CHEMBL392657	147009	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assayAntagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assay	ChEMBL	594	5	4	7	2.5	CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(Cl)c2)NCCOc2ccccc2CCCNC(=O)[C@H](Cn2cccn2)NC1=O	10.1016/j.bmcl.2007.05.043
	12016400	168960	0	None	11	2	Rabbit	6.2	pIC50	=	6.2	Functional	Activity at rabbit duodenum motilin receptor by tissue contractility assayActivity at rabbit duodenum motilin receptor by tissue contractility assay	ChEMBL	613	11	0	4	7.6	CC(C)(C)C(=O)N(Cc1ccccc1)[C@H]1CCC[C@@H](CN(C(=O)c2ccc(F)cc2)c2cccc(OCCN3CCCC3)c2)C1	10.1016/j.bmcl.2006.04.017
	CHEMBL438962	168960	0	None	11	2	Rabbit	6.2	pIC50	=	6.2	Functional	Activity at rabbit duodenum motilin receptor by tissue contractility assayActivity at rabbit duodenum motilin receptor by tissue contractility assay	ChEMBL	613	11	0	4	7.6	CC(C)(C)C(=O)N(Cc1ccccc1)[C@H]1CCC[C@@H](CN(C(=O)c2ccc(F)cc2)c2cccc(OCCN3CCCC3)c2)C1	10.1016/j.bmcl.2006.04.017
	44412894	138910	0	None	1	2	Rabbit	7.1	pIC50	=	7.1	Functional	Activity at rabbit duodenum motilin receptor by tissue contractility assayActivity at rabbit duodenum motilin receptor by tissue contractility assay	ChEMBL	718	12	0	6	7.8	O=C(c1ccc(F)cc1)N(CC1CCCC(N(Cc2cccc([N+](=O)[O-])c2)C(=O)C(Cl)(Cl)Cl)C1)c1cccc(OCCN2CCCC2)c1	10.1016/j.bmcl.2006.04.017
	CHEMBL378317	138910	0	None	1	2	Rabbit	7.1	pIC50	=	7.1	Functional	Activity at rabbit duodenum motilin receptor by tissue contractility assayActivity at rabbit duodenum motilin receptor by tissue contractility assay	ChEMBL	718	12	0	6	7.8	O=C(c1ccc(F)cc1)N(CC1CCCC(N(Cc2cccc([N+](=O)[O-])c2)C(=O)C(Cl)(Cl)Cl)C1)c1cccc(OCCN2CCCC2)c1	10.1016/j.bmcl.2006.04.017
	11994554	80572	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Activity at human MOTR expressed in CHO cells assessed as inhibition of motilin-induced calcium releaseActivity at human MOTR expressed in CHO cells assessed as inhibition of motilin-induced calcium release	ChEMBL	536	5	5	6	2.5	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC1=O	10.1021/jm0606600
	CHEMBL214935	80572	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Activity at human MOTR expressed in CHO cells assessed as inhibition of motilin-induced calcium releaseActivity at human MOTR expressed in CHO cells assessed as inhibition of motilin-induced calcium release	ChEMBL	536	5	5	6	2.5	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC1=O	10.1021/jm0606600
	11994554	80572	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assayAntagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assay	ChEMBL	536	5	5	6	2.5	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC1=O	10.1016/j.bmcl.2007.05.043
	CHEMBL214935	80572	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assayAntagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assay	ChEMBL	536	5	5	6	2.5	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC1=O	10.1016/j.bmcl.2007.05.043
	9895192	77855	0	None	38	2	Rabbit	8.1	pIC50	=	8.1	Functional	Activity at rabbit duodenum motilin receptor by tissue contractility assayActivity at rabbit duodenum motilin receptor by tissue contractility assay	ChEMBL	613	11	0	4	7.6	CC(C)(C)C(=O)N(Cc1ccccc1)[C@@H]1CCC[C@H](CN(C(=O)c2ccc(F)cc2)c2cccc(OCCN3CCCC3)c2)C1	10.1016/j.bmcl.2006.04.017
	CHEMBL209301	77855	0	None	38	2	Rabbit	8.1	pIC50	=	8.1	Functional	Activity at rabbit duodenum motilin receptor by tissue contractility assayActivity at rabbit duodenum motilin receptor by tissue contractility assay	ChEMBL	613	11	0	4	7.6	CC(C)(C)C(=O)N(Cc1ccccc1)[C@@H]1CCC[C@H](CN(C(=O)c2ccc(F)cc2)c2cccc(OCCN3CCCC3)c2)C1	10.1016/j.bmcl.2006.04.017
	44432973	98312	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assayAntagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assay	ChEMBL	577	4	5	6	1.9	CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(C(F)(F)F)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CN)NC1=O	10.1016/j.bmcl.2007.05.043
	CHEMBL274876	98312	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assayAntagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assay	ChEMBL	577	4	5	6	1.9	CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(C(F)(F)F)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CN)NC1=O	10.1016/j.bmcl.2007.05.043
	44432976	154864	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assayAntagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assay	ChEMBL	571	5	4	6	2.2	CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(Cl)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CN(C)C)NC1=O	10.1016/j.bmcl.2007.05.043
	CHEMBL400635	154864	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assayAntagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assay	ChEMBL	571	5	4	6	2.2	CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(Cl)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CN(C)C)NC1=O	10.1016/j.bmcl.2007.05.043
	23557218	139556	0	None	-38	2	Human	6.0	pIC50	=	6	Functional	Activity at human motilin receptor transfected in HEK293 cells assessed as inhibition of motilin-induced intracellular calcium mobilizationActivity at human motilin receptor transfected in HEK293 cells assessed as inhibition of motilin-induced intracellular calcium mobilization	ChEMBL	613	11	0	4	7.6	CC(C)(C)C(=O)N(Cc1ccccc1)C1CCCC(CN(C(=O)c2ccc(F)cc2)c2cccc(OCCN3CCCC3)c2)C1	10.1016/j.bmcl.2006.04.017
	CHEMBL379665	139556	0	None	-38	2	Human	6.0	pIC50	=	6	Functional	Activity at human motilin receptor transfected in HEK293 cells assessed as inhibition of motilin-induced intracellular calcium mobilizationActivity at human motilin receptor transfected in HEK293 cells assessed as inhibition of motilin-induced intracellular calcium mobilization	ChEMBL	613	11	0	4	7.6	CC(C)(C)C(=O)N(Cc1ccccc1)C1CCCC(CN(C(=O)c2ccc(F)cc2)c2cccc(OCCN3CCCC3)c2)C1	10.1016/j.bmcl.2006.04.017
	CHEMBL496391	214083	0	None	-	1	Rabbit	7.9	pKd	=	7.9	Functional	Antagonist activity at MTL receptor in rabbit duodenum homogenateAntagonist activity at MTL receptor in rabbit duodenum homogenate	ChEMBL		None	None	None		CC(C)[C@@H](C(=O)N[C@@H](Cc1ccc(O)c(C(C)(C)C)c1)C(N)=O)N(C)C(=O)[C@@H](N)Cc1ccccc1	10.1016/j.bmcl.2009.05.059
	CHEMBL496389	214081	0	None	-	1	Rabbit	6.9	pKd	=	6.9	Functional	Antagonist activity at MTL receptor in rabbit duodenum homogenateAntagonist activity at MTL receptor in rabbit duodenum homogenate	ChEMBL		None	None	None		CC(C)[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)c(C(C)(C)C)c1)C(N)=O	10.1016/j.bmcl.2009.05.059
	CHEMBL497004	214084	0	None	-	1	Rabbit	7.8	pKd	=	7.8	Functional	Antagonist activity at MTL receptor in rabbit duodenum homogenateAntagonist activity at MTL receptor in rabbit duodenum homogenate	ChEMBL		None	None	None		CC(C)(C)c1cc(C[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccccc2)c2ccccc2)C(N)=O)ccc1O	10.1016/j.bmcl.2009.05.059
	44583348	187840	0	None	-	1	Rabbit	8.6	pKd	=	8.6	Functional	Antagonist activity at MTL receptor in rabbit duodenum homogenateAntagonist activity at MTL receptor in rabbit duodenum homogenate	ChEMBL	510	10	3	5	2.6	CC(C)[C@@H](C(=O)N(C)[C@@H](Cc1ccc(O)c(C(C)(C)C)c1)C(N)=O)N(C)C(=O)[C@@H](N)Cc1ccccc1	10.1016/j.bmcl.2009.05.059
	CHEMBL496190	187840	0	None	-	1	Rabbit	8.6	pKd	=	8.6	Functional	Antagonist activity at MTL receptor in rabbit duodenum homogenateAntagonist activity at MTL receptor in rabbit duodenum homogenate	ChEMBL	510	10	3	5	2.6	CC(C)[C@@H](C(=O)N(C)[C@@H](Cc1ccc(O)c(C(C)(C)C)c1)C(N)=O)N(C)C(=O)[C@@H](N)Cc1ccccc1	10.1016/j.bmcl.2009.05.059
	9956253	187841	0	None	-	1	Rabbit	8.4	pKd	=	8.4	Functional	Antagonist activity at MTL receptor in rabbit duodenum homogenateAntagonist activity at MTL receptor in rabbit duodenum homogenate	ChEMBL	467	9	3	4	3.8	CC(C)[C@@H](C(=O)N[C@H](C)Cc1ccc(O)c(C(C)(C)C)c1)N(C)C(=O)[C@@H](N)Cc1ccccc1	10.1016/j.bmcl.2009.05.059
	CHEMBL496191	187841	0	None	-	1	Rabbit	8.4	pKd	=	8.4	Functional	Antagonist activity at MTL receptor in rabbit duodenum homogenateAntagonist activity at MTL receptor in rabbit duodenum homogenate	ChEMBL	467	9	3	4	3.8	CC(C)[C@@H](C(=O)N[C@H](C)Cc1ccc(O)c(C(C)(C)C)c1)N(C)C(=O)[C@@H](N)Cc1ccccc1	10.1016/j.bmcl.2009.05.059
	44583286	193450	0	None	-	1	Rabbit	7.4	pKd	=	7.4	Functional	Antagonist activity at MTL receptor in rabbit duodenum homogenateAntagonist activity at MTL receptor in rabbit duodenum homogenate	ChEMBL	564	6	5	6	2.8	CC(C)(C)c1cc(C[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H](N)Cc3ccccc3)CCCCCC(=O)CCNC2=O)ccc1O	10.1016/j.bmcl.2009.05.059
	CHEMBL526496	193450	0	None	-	1	Rabbit	7.4	pKd	=	7.4	Functional	Antagonist activity at MTL receptor in rabbit duodenum homogenateAntagonist activity at MTL receptor in rabbit duodenum homogenate	ChEMBL	564	6	5	6	2.8	CC(C)(C)c1cc(C[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H](N)Cc3ccccc3)CCCCCC(=O)CCNC2=O)ccc1O	10.1016/j.bmcl.2009.05.059
	CHEMBL496390	214082	0	None	-	1	Rabbit	7.3	pKd	=	7.3	Functional	Antagonist activity at MTL receptor in rabbit duodenum homogenateAntagonist activity at MTL receptor in rabbit duodenum homogenate	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)c(C(C)(C)C)c1)C(N)=O	10.1016/j.bmcl.2009.05.059
	44583347	187820	0	None	-	1	Rabbit	7.2	pKd	=	7.2	Functional	Antagonist activity at MTL receptor in rabbit duodenum homogenateAntagonist activity at MTL receptor in rabbit duodenum homogenate	ChEMBL	496	10	4	5	2.3	CC(C)[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N(C)[C@@H](Cc1ccc(O)c(C(C)(C)C)c1)C(N)=O	10.1016/j.bmcl.2009.05.059
	CHEMBL495994	187820	0	None	-	1	Rabbit	7.2	pKd	=	7.2	Functional	Antagonist activity at MTL receptor in rabbit duodenum homogenateAntagonist activity at MTL receptor in rabbit duodenum homogenate	ChEMBL	496	10	4	5	2.3	CC(C)[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N(C)[C@@H](Cc1ccc(O)c(C(C)(C)C)c1)C(N)=O	10.1016/j.bmcl.2009.05.059
	CHEMBL502792	214158	0	None	-	1	Rabbit	7.2	pKd	=	7.2	Functional	Antagonist activity at MTL receptor in rabbit duodenum homogenateAntagonist activity at MTL receptor in rabbit duodenum homogenate	ChEMBL		None	None	None		CC(C)(C)c1cc(C[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)Cc2ccccc2)C(N)=O)ccc1O	10.1016/j.bmcl.2009.05.059
	1466	1828	0	None	-	1	Rabbit	7.4	pA2	=	7.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10081621
	1466	1828	0	None	-	1	Rabbit	7.4	pA2	=	7.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	7752063
	9850904	1828	0	None	-	1	Rabbit	7.4	pA2	=	7.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10081621
	9850904	1828	0	None	-	1	Rabbit	7.4	pA2	=	7.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	7752063
	CHEMBL3143516	1828	0	None	-	1	Rabbit	7.4	pA2	=	7.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10081621
	CHEMBL3143516	1828	0	None	-	1	Rabbit	7.4	pA2	=	7.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	7752063
	4036	2452	0	None	-	1	Human	9.2	pA2	=	9.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	592	12	4	5	3.7	CCNC(=O)[C@@H](NC(=O)[C@@H](N(C(=O)[C@H](Cc1ccc(cc1)F)NC)C)C(C)C)Cc1ccc(c(c1)C(C)(C)C)O.Cl	18164286
	73755070	2452	0	None	-	1	Human	9.2	pA2	=	9.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	592	12	4	5	3.7	CCNC(=O)[C@@H](NC(=O)[C@@H](N(C(=O)[C@H](Cc1ccc(cc1)F)NC)C)C(C)C)Cc1ccc(c(c1)C(C)(C)C)O.Cl	18164286
	138107041	561	65	None	60	3	Human	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	749	7	5	14	1.9	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](CN([C@@H]([C@H]([C@]1(C)O)O)C)C)C)(C)O	None
	276	561	65	None	60	3	Human	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	749	7	5	14	1.9	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](CN([C@@H]([C@H]([C@]1(C)O)O)C)C)C)(C)O	None
	447043	561	65	None	60	3	Human	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	749	7	5	14	1.9	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](CN([C@@H]([C@H]([C@]1(C)O)O)C)C)C)(C)O	None
	6510	561	65	None	60	3	Human	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	749	7	5	14	1.9	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](CN([C@@H]([C@H]([C@]1(C)O)O)C)C)C)(C)O	None
	CHEMBL529	561	65	None	60	3	Human	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	749	7	5	14	1.9	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](CN([C@@H]([C@H]([C@]1(C)O)O)C)C)C)(C)O	None
	DB00207	561	65	None	60	3	Human	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	749	7	5	14	1.9	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](CN([C@@H]([C@H]([C@]1(C)O)O)C)C)C)(C)O	None
	138107041	561	65	None	60	3	Human	5.5	pEC50	=	5.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	749	7	5	14	1.9	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](CN([C@@H]([C@H]([C@]1(C)O)O)C)C)C)(C)O	23190027
	276	561	65	None	60	3	Human	5.5	pEC50	=	5.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	749	7	5	14	1.9	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](CN([C@@H]([C@H]([C@]1(C)O)O)C)C)C)(C)O	23190027
	447043	561	65	None	60	3	Human	5.5	pEC50	=	5.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	749	7	5	14	1.9	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](CN([C@@H]([C@H]([C@]1(C)O)O)C)C)C)(C)O	23190027
	6510	561	65	None	60	3	Human	5.5	pEC50	=	5.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	749	7	5	14	1.9	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](CN([C@@H]([C@H]([C@]1(C)O)O)C)C)C)(C)O	23190027
	CHEMBL529	561	65	None	60	3	Human	5.5	pEC50	=	5.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	749	7	5	14	1.9	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](CN([C@@H]([C@H]([C@]1(C)O)O)C)C)C)(C)O	23190027
	DB00207	561	65	None	60	3	Human	5.5	pEC50	=	5.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	749	7	5	14	1.9	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](CN([C@@H]([C@H]([C@]1(C)O)O)C)C)C)(C)O	23190027
	177964	2544	2	None	-3	2	Rabbit	7.7	pEC50	=	7.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	755	9	2	13	4.5	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@H]([C@]2(OC(=C(C)C2)[C@@H](C(=O)[C@]1(C)OC)C)C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C(C)C)C	17183187
	3511	2544	2	None	-3	2	Rabbit	7.7	pEC50	=	7.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	755	9	2	13	4.5	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@H]([C@]2(OC(=C(C)C2)[C@@H](C(=O)[C@]1(C)OC)C)C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C(C)C)C	17183187
	CHEMBL1778156	2544	2	None	-3	2	Rabbit	7.7	pEC50	=	7.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	755	9	2	13	4.5	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@H]([C@]2(OC(=C(C)C2)[C@@H](C(=O)[C@]1(C)OC)C)C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C(C)C)C	17183187
	15984937	785	31	None	-	1	Human	7.9	pEC50	=	7.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	424	6	2	4	3.3	C[C@@H]1NCCN(C1)Cc1ccc(cc1)CC(=O)N1CCC(CC1)Nc1cccc(c1)F	19374732
	15984937	785	31	None	-	1	Human	7.9	pEC50	=	7.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	424	6	2	4	3.3	C[C@@H]1NCCN(C1)Cc1ccc(cc1)CC(=O)N1CCC(CC1)Nc1cccc(c1)F	25341626
	4035	785	31	None	-	1	Human	7.9	pEC50	=	7.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	424	6	2	4	3.3	C[C@@H]1NCCN(C1)Cc1ccc(cc1)CC(=O)N1CCC(CC1)Nc1cccc(c1)F	19374732
	4035	785	31	None	-	1	Human	7.9	pEC50	=	7.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	424	6	2	4	3.3	C[C@@H]1NCCN(C1)Cc1ccc(cc1)CC(=O)N1CCC(CC1)Nc1cccc(c1)F	25341626
	CHEMBL489095	785	31	None	-	1	Human	7.9	pEC50	=	7.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	424	6	2	4	3.3	C[C@@H]1NCCN(C1)Cc1ccc(cc1)CC(=O)N1CCC(CC1)Nc1cccc(c1)F	19374732
	CHEMBL489095	785	31	None	-	1	Human	7.9	pEC50	=	7.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	424	6	2	4	3.3	C[C@@H]1NCCN(C1)Cc1ccc(cc1)CC(=O)N1CCC(CC1)Nc1cccc(c1)F	25341626
	DB12567	785	31	None	-	1	Human	7.9	pEC50	=	7.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	424	6	2	4	3.3	C[C@@H]1NCCN(C1)Cc1ccc(cc1)CC(=O)N1CCC(CC1)Nc1cccc(c1)F	19374732
	DB12567	785	31	None	-	1	Human	7.9	pEC50	=	7.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	424	6	2	4	3.3	C[C@@H]1NCCN(C1)Cc1ccc(cc1)CC(=O)N1CCC(CC1)Nc1cccc(c1)F	25341626
	11902	1487	8	None	-	1	Human	8.3	pEC50	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	465	7	2	5	3.9	C[C@H]1CN(Cc2ccc(cc2C)N(C)C(=O)[C@H]2CC[C@@H](CC2)Oc2cc(CO)ccc2)CCN1	35051575
	56960876	1487	8	None	-	1	Human	8.3	pEC50	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	465	7	2	5	3.9	C[C@H]1CN(Cc2ccc(cc2C)N(C)C(=O)[C@H]2CC[C@@H](CC2)Oc2cc(CO)ccc2)CCN1	35051575
	CHEMBL5201797	1487	8	None	-	1	Human	8.3	pEC50	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	465	7	2	5	3.9	C[C@H]1CN(Cc2ccc(cc2C)N(C)C(=O)[C@H]2CC[C@@H](CC2)Oc2cc(CO)ccc2)CCN1	35051575
	139592915	3374	35	None	3	2	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	837	13	5	17	2.2	COCCOCO/N=C/1\[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@H](C)[C@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C(=O)O[C@@H]([C@@]([C@@H]([C@H]1C)O)(C)O)CC)C	None
	1465	3374	35	None	3	2	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	837	13	5	17	2.2	COCCOCO/N=C/1\[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@H](C)[C@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C(=O)O[C@@H]([C@@]([C@@H]([C@H]1C)O)(C)O)CC)C	None
	2410	3374	35	None	3	2	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	837	13	5	17	2.2	COCCOCO/N=C/1\[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@H](C)[C@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C(=O)O[C@@H]([C@@]([C@@H]([C@H]1C)O)(C)O)CC)C	None
	6915744	3374	35	None	3	2	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	837	13	5	17	2.2	COCCOCO/N=C/1\[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@H](C)[C@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C(=O)O[C@@H]([C@@]([C@@H]([C@H]1C)O)(C)O)CC)C	None
	CHEMBL1214185	3374	35	None	3	2	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	837	13	5	17	2.2	COCCOCO/N=C/1\[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@H](C)[C@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C(=O)O[C@@H]([C@@]([C@@H]([C@H]1C)O)(C)O)CC)C	None
	DB00778	3374	35	None	3	2	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	837	13	5	17	2.2	COCCOCO/N=C/1\[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@H](C)[C@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C(=O)O[C@@H]([C@@]([C@@H]([C@H]1C)O)(C)O)CC)C	None
	1048	1585	76	None	2	4	Human	6.0	pIC50	=	6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10381885
	1048	1585	76	None	2	4	Human	6.0	pIC50	=	6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	15764739
	12560	1585	76	None	2	4	Human	6.0	pIC50	=	6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10381885
	12560	1585	76	None	2	4	Human	6.0	pIC50	=	6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	15764739
	1456	1585	76	None	2	4	Human	6.0	pIC50	=	6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10381885
	1456	1585	76	None	2	4	Human	6.0	pIC50	=	6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	15764739
	CHEMBL532	1585	76	None	2	4	Human	6.0	pIC50	=	6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10381885
	CHEMBL532	1585	76	None	2	4	Human	6.0	pIC50	=	6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	15764739
	DB00199	1585	76	None	2	4	Human	6.0	pIC50	=	6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10381885
	DB00199	1585	76	None	2	4	Human	6.0	pIC50	=	6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	15764739
	1444	341	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	697	8	2	11	5.2	CCN([C@H]1C[C@@H](C)O[C@H]([C@@H]1O)O[C@@H]1[C@@H](C)[C@H](O[C@@H]2O[C@@H](C)C[C@](C2)(C)OC)[C@@H](C)C(=O)O[C@@H]([C@@H]([C@@H]([C@H](C2=C(C[C@@]1(C)O2)C)C)O)C)CC)C	15764739
	9918079	341	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	697	8	2	11	5.2	CCN([C@H]1C[C@@H](C)O[C@H]([C@@H]1O)O[C@@H]1[C@@H](C)[C@H](O[C@@H]2O[C@@H](C)C[C@](C2)(C)OC)[C@@H](C)C(=O)O[C@@H]([C@@H]([C@@H]([C@H](C2=C(C[C@@]1(C)O2)C)C)O)C)CC)C	15764739
	CHEMBL300049	341	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	697	8	2	11	5.2	CCN([C@H]1C[C@@H](C)O[C@H]([C@@H]1O)O[C@@H]1[C@@H](C)[C@H](O[C@@H]2O[C@@H](C)C[C@](C2)(C)OC)[C@@H](C)C(=O)O[C@@H]([C@@H]([C@@H]([C@H](C2=C(C[C@@]1(C)O2)C)C)O)C)CC)C	15764739
	1466	1828	0	None	-	1	Rabbit	8.0	pIC50	=	8	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11806718
	9850904	1828	0	None	-	1	Rabbit	8.0	pIC50	=	8	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11806718
	CHEMBL3143516	1828	0	None	-	1	Rabbit	8.0	pIC50	=	8	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11806718
	177964	2544	2	None	-3	2	Rabbit	8.2	pIC50	=	8.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	755	9	2	13	4.5	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@H]([C@]2(OC(=C(C)C2)[C@@H](C(=O)[C@]1(C)OC)C)C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C(C)C)C	10081621
	3511	2544	2	None	-3	2	Rabbit	8.2	pIC50	=	8.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	755	9	2	13	4.5	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@H]([C@]2(OC(=C(C)C2)[C@@H](C(=O)[C@]1(C)OC)C)C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C(C)C)C	10081621
	CHEMBL1778156	2544	2	None	-3	2	Rabbit	8.2	pIC50	=	8.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	755	9	2	13	4.5	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@H]([C@]2(OC(=C(C)C2)[C@@H](C(=O)[C@]1(C)OC)C)C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C(C)C)C	10081621
	1447	2478	0	None	-	1	Human	4.7	pIC50	None	4.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	747	8	5	14	2.2	CCN(C1CC(C)OC(C1O)OC1C(C)C(OC2OC(C)C(C(C2)(C)OC)O)C(C)C(=O)OC(CC)C(C(C(C(=O)C(CC1(C)O)C)C)O)(C)O)C	15764739
	14487390	2478	0	None	-	1	Human	4.7	pIC50	None	4.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	747	8	5	14	2.2	CCN(C1CC(C)OC(C1O)OC1C(C)C(OC2OC(C)C(C(C2)(C)OC)O)C(C)C(=O)OC(CC)C(C(C(C(=O)C(CC1(C)O)C)C)O)(C)O)C	15764739
	139592915	3374	35	None	3	2	Human	6.2	pIC50	None	6.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	837	13	5	17	2.2	COCCOCO/N=C/1\[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@H](C)[C@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C(=O)O[C@@H]([C@@]([C@@H]([C@H]1C)O)(C)O)CC)C	10381885
	1465	3374	35	None	3	2	Human	6.2	pIC50	None	6.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	837	13	5	17	2.2	COCCOCO/N=C/1\[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@H](C)[C@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C(=O)O[C@@H]([C@@]([C@@H]([C@H]1C)O)(C)O)CC)C	10381885
	2410	3374	35	None	3	2	Human	6.2	pIC50	None	6.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	837	13	5	17	2.2	COCCOCO/N=C/1\[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@H](C)[C@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C(=O)O[C@@H]([C@@]([C@@H]([C@H]1C)O)(C)O)CC)C	10381885
	6915744	3374	35	None	3	2	Human	6.2	pIC50	None	6.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	837	13	5	17	2.2	COCCOCO/N=C/1\[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@H](C)[C@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C(=O)O[C@@H]([C@@]([C@@H]([C@H]1C)O)(C)O)CC)C	10381885
	CHEMBL1214185	3374	35	None	3	2	Human	6.2	pIC50	None	6.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	837	13	5	17	2.2	COCCOCO/N=C/1\[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@H](C)[C@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C(=O)O[C@@H]([C@@]([C@@H]([C@H]1C)O)(C)O)CC)C	10381885
	DB00778	3374	35	None	3	2	Human	6.2	pIC50	None	6.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	837	13	5	17	2.2	COCCOCO/N=C/1\[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@H](C)[C@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C(=O)O[C@@H]([C@@]([C@@H]([C@H]1C)O)(C)O)CC)C	10381885
	1448	2479	34	None	-2	2	Human	6.3	pIC50	None	6.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	715	7	4	13	2.9	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@H]([C@@]2(OC(=C(C)C2)[C@@H]([C@H]([C@]1(C)O)O)C)C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C)C	15764739
	83954	2479	34	None	-2	2	Human	6.3	pIC50	None	6.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	715	7	4	13	2.9	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@H]([C@@]2(OC(=C(C)C2)[C@@H]([C@H]([C@]1(C)O)O)C)C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C)C	15764739
	CHEMBL300004	2479	34	None	-2	2	Human	6.3	pIC50	None	6.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	715	7	4	13	2.9	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@H]([C@@]2(OC(=C(C)C2)[C@@H]([C@H]([C@]1(C)O)O)C)C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C)C	15764739
	10032648	2480	0	None	-	1	Human	6.5	pIC50	None	6.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	699	7	3	12	3.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@H]([C@]2(OC(=C(C)C2)[C@@H]([C@H]([C@@H]1C)O)C)C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C)C	15764739
	1449	2480	0	None	-	1	Human	6.5	pIC50	None	6.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	699	7	3	12	3.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@H]([C@]2(OC(=C(C)C2)[C@@H]([C@H]([C@@H]1C)O)C)C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C)C	15764739
	1445	1550	0	None	-	1	Human	6.6	pIC50	None	6.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	729	8	4	13	3.3	CCN([C@H]1C[C@@H](C)O[C@H]([C@@H]1O)O[C@@H]1[C@@H](C)[C@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@@H](C)C(=O)O[C@@H]([C@@]([C@@H]([C@H](C2=C(C[C@]1(C)O2)C)C)O)(C)O)CC)C	15764739
	184178	1550	0	None	-	1	Human	6.6	pIC50	None	6.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	729	8	4	13	3.3	CCN([C@H]1C[C@@H](C)O[C@H]([C@@H]1O)O[C@@H]1[C@@H](C)[C@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@@H](C)C(=O)O[C@@H]([C@@]([C@@H]([C@H](C2=C(C[C@]1(C)O2)C)C)O)(C)O)CC)C	15764739
	1460	2599	0	None	-	1	Human	6.8	pIC50	None	6.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10381885
	155817408	2599	0	None	-	1	Human	6.8	pIC50	None	6.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10381885
	10259168	2199	0	None	-	1	Human	7.2	pIC50	None	7.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	699	7	3	12	3.9	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)C[C@](C2)(C)OC)[C@H](C)[C@H]([C@@]2(OC(=C(C)C2)[C@@H]([C@H]([C@]1(C)O)O)C)C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C)C	15764739
	1446	2199	0	None	-	1	Human	7.2	pIC50	None	7.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	699	7	3	12	3.9	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)C[C@](C2)(C)OC)[C@H](C)[C@H]([C@@]2(OC(=C(C)C2)[C@@H]([C@H]([C@]1(C)O)O)C)C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C)C	15764739
	CHEMBL51522	2199	0	None	-	1	Human	7.2	pIC50	None	7.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	699	7	3	12	3.9	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)C[C@](C2)(C)OC)[C@H](C)[C@H]([C@@]2(OC(=C(C)C2)[C@@H]([C@H]([C@]1(C)O)O)C)C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C)C	15764739
	1464	2603	0	None	-	1	Human	7.5	pIC50	None	7.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10381885
	155817411	2603	0	None	-	1	Human	7.5	pIC50	None	7.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10381885
	1454	3105	0	None	-	1	Human	8.9	pIC50	None	8.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10381885
	101650014	2299	0	None	-	1	Human	9.0	pIC50	None	9	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10381885
	1453	2299	0	None	-	1	Human	9.0	pIC50	None	9	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10381885
	16198245	2299	0	None	-	1	Human	9.0	pIC50	None	9	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10381885
	91898971	2299	0	None	-	1	Human	9.0	pIC50	None	9	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10381885
	101930759	2600	0	None	-	1	Human	9.0	pIC50	None	9	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10381885
	1461	2600	0	None	-	1	Human	9.0	pIC50	None	9	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10381885
	1457	2598	0	None	-	1	Human	9.3	pIC50	None	9.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10381885
	155817406	2598	0	None	-	1	Human	9.3	pIC50	None	9.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10381885
	16139289	2598	0	None	-	1	Human	9.3	pIC50	None	9.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10381885
	71311666	2598	0	None	-	1	Human	9.3	pIC50	None	9.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10381885
	1462	2601	0	None	-	1	Human	9.5	pIC50	None	9.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10381885
	155817409	2601	0	None	-	1	Human	9.5	pIC50	None	9.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10381885
	1463	2602	0	None	-	1	Human	9.5	pIC50	None	9.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10381885
	155817410	2602	0	None	-	1	Human	9.5	pIC50	None	9.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10381885
	1455	2829	0	None	-	1	Human	9.5	pIC50	None	9.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10381885
	1459	2597	0	None	-	1	Human	9.7	pIC50	None	9.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10381885
	155817407	2597	0	None	-	1	Human	9.7	pIC50	None	9.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10381885

Get vendors

Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Similar- ity	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
		103	4153	61	None	-	53	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		2875	4153	61	None	-	53	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		5736	4153	61	None	-	53	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		CHEMBL285802	4153	61	None	-	53	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		DB09225	4153	61	None	-	53	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		1385580	29276	76	None	-	5	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
		4615	29276	76	None	-	5	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
		CHEMBL13828	29276	76	None	-	5	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
		392622	56312	95	None	-	4	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	720	17	4	9	5.9	CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1	10.1038/s41467-023-40064-9
		CHEMBL163	56312	95	None	-	4	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	720	17	4	9	5.9	CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1	10.1038/s41467-023-40064-9
		26987	949	33	None	-	21	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		6063	949	33	None	-	21	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		671	949	33	None	-	21	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		CHEMBL1626	949	33	None	-	21	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		DB00283	949	33	None	-	21	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		65866	94264	73	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	611	12	1	8	6.5	COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)(C)CN(C)CCC(c2ccccc2)c2ccccc2)C1c1cccc([N+](=O)[O-])c1	10.1038/s41467-023-40064-9
		CHEMBL250270	94264	73	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	611	12	1	8	6.5	COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)(C)CN(C)CCC(c2ccccc2)c2ccccc2)C1c1cccc([N+](=O)[O-])c1	10.1038/s41467-023-40064-9
		41684	31221	105	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	307	4	1	7	2.2	CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1	10.1038/s41467-023-40064-9
		CHEMBL1401	31221	105	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	307	4	1	7	2.2	CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1	10.1038/s41467-023-40064-9
		127151	35330	18	None	-	10	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	313	6	1	4	3.2	CCOc1ccccc1OC(c1ccccc1)C1CNCCO1	10.1038/s41467-023-40064-9
		3022645	35330	18	None	-	10	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	313	6	1	4	3.2	CCOc1ccccc1OC(c1ccccc1)C1CNCCO1	10.1038/s41467-023-40064-9
		CHEMBL14370	35330	18	None	-	10	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	313	6	1	4	3.2	CCOc1ccccc1OC(c1ccccc1)C1CNCCO1	10.1038/s41467-023-40064-9
		10184665	3991	51	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
		4799	3991	51	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
		7353	3991	51	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
		CHEMBL1198857	3991	51	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
		DB09082	3991	51	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
		25382	9157	37	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	291	3	0	1	4.7	CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL110094	9157	37	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	291	3	0	1	4.7	CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21	10.1038/s41467-023-40064-9
		24826799	10798	104	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	532	4	1	6	4.5	Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12	10.1038/s41467-023-40064-9
		CHEMBL1171837	10798	104	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	532	4	1	6	4.5	Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12	10.1038/s41467-023-40064-9
		16722836	18985	99	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	524	10	3	8	4.8	Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(S(=O)(=O)NC(C)(C)C)c1	10.1038/s41467-023-40064-9
		CHEMBL1287853	18985	99	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	524	10	3	8	4.8	Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(S(=O)(=O)NC(C)(C)C)c1	10.1038/s41467-023-40064-9
		3784	57172	101	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	371	4	1	8	2.6	COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)C)C1c1cccc2nonc12	10.1038/s41467-023-40064-9
		CHEMBL1648	57172	101	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	371	4	1	8	2.6	COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)C)C1c1cccc2nonc12	10.1038/s41467-023-40064-9
		4942	5718	50	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	367	7	0	4	4.0	CCCOC(C(=O)OC1CCN(C)CC1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL1078261	5718	50	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	367	7	0	4	4.0	CCCOC(C(=O)OC1CCN(C)CC1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		3191	102858	97	None	-	25	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	10.1038/s41467-023-40064-9
		CHEMBL305660	102858	97	None	-	25	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	10.1038/s41467-023-40064-9
		176	398	66	None	-	31	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
		2157	398	66	None	-	31	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
		2566	398	66	None	-	31	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
		CHEMBL633	398	66	None	-	31	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
		DB01118	398	66	None	-	31	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
		65948	18556	109	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	582	9	2	9	4.7	CC1=C(C(=O)OC(C)C)C(c2cccc([N+](=O)[O-])c2)C(C(=O)OC2CN(C(c3ccccc3)c3ccccc3)C2)=C(N)N1	10.1038/s41467-023-40064-9
		CHEMBL1275868	18556	109	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	582	9	2	9	4.7	CC1=C(C(=O)OC(C)C)C(c2cccc([N+](=O)[O-])c2)C(C(=O)OC2CN(C(c3ccccc3)c3ccccc3)C2)=C(N)N1	10.1038/s41467-023-40064-9
		5284535	59111	26	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	392	2	3	5	1.9	C[C@]12C=CC(=O)C=C1C(Cl)=C[C@@H]1[C@@H]2[C@@H](O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)CO	10.1038/s41467-023-40064-9
		CHEMBL1697832	59111	26	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	392	2	3	5	1.9	C[C@]12C=CC(=O)C=C1C(Cl)=C[C@@H]1[C@@H]2[C@@H](O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)CO	10.1038/s41467-023-40064-9
		154257	178619	67	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
		CHEMBL46740	178619	67	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
		11626560	200937	94	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	449	5	2	6	5.0	C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl	10.1038/s41467-023-40064-9
		CHEMBL601719	200937	94	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	449	5	2	6	5.0	C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl	10.1038/s41467-023-40064-9
		135409453	3773	41	None	-	2	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
		226	3773	41	None	-	2	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
		CHEMBL76370	3773	41	None	-	2	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
		65709	59881	39	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	365	8	0	5	3.3	CCN(CC)CCn1c(=O)c(Cc2ccc(OC)cc2)nc2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL1729803	59881	39	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	365	8	0	5	3.3	CCN(CC)CCn1c(=O)c(Cc2ccc(OC)cc2)nc2ccccc21	10.1038/s41467-023-40064-9
		25181577	78219	56	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	574	9	2	9	5.0	CCOC(=O)[C@@H](N)Cc1ccc(-c2cc(O[C@H](c3ccc(Cl)cc3-n3ccc(C)n3)C(F)(F)F)nc(N)n2)cc1	10.1038/s41467-023-40064-9
		CHEMBL2105695	78219	56	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	574	9	2	9	5.0	CCOC(=O)[C@@H](N)Cc1ccc(-c2cc(O[C@H](c3ccc(Cl)cc3-n3ccc(C)n3)C(F)(F)F)nc(N)n2)cc1	10.1038/s41467-023-40064-9
		16362	3125	71	None	-	30	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		2172	3125	71	None	-	30	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		90	3125	71	None	-	30	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL1423	3125	71	None	-	30	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		DB01100	3125	71	None	-	30	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		240	944	43	None	-	24	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1038/s41467-023-40064-9
		2769	944	43	None	-	24	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1038/s41467-023-40064-9
		44279790	944	43	None	-	24	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1038/s41467-023-40064-9
		660	944	43	None	-	24	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1038/s41467-023-40064-9
		CHEMBL1729	944	43	None	-	24	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1038/s41467-023-40064-9
		CHEMBL560739	944	43	None	-	24	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1038/s41467-023-40064-9
		DB00604	944	43	None	-	24	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1038/s41467-023-40064-9
		68617	205527	62	None	-	26	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL1709	205527	62	None	-	26	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL809	205527	62	None	-	26	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
		11976	920	59	None	-	24	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
		667467	920	59	None	-	24	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
		CHEMBL908	920	59	None	-	24	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
		DB01239	920	59	None	-	24	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
		275196	125673	52	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	413	4	0	8	2.9	COc1ccc2c(c1OC)C(=O)O[C@@H]2[C@H]1c2c(cc3c(c2OC)OCO3)CCN1C	10.1038/s41467-023-40064-9
		CHEMBL364713	125673	52	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	413	4	0	8	2.9	COc1ccc2c(c1OC)C(=O)O[C@@H]2[C@H]1c2c(cc3c(c2OC)OCO3)CCN1C	10.1038/s41467-023-40064-9
		2351	4300	49	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	366	10	0	3	4.8	CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1	10.1038/s41467-023-40064-9
		CHEMBL1008	4300	49	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	366	10	0	3	4.8	CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1	10.1038/s41467-023-40064-9
		CHEMBL1257078	4300	49	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	366	10	0	3	4.8	CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1	10.1038/s41467-023-40064-9
		4150	788	39	None	-	11	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
		5288	788	39	None	-	11	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
		644019	788	39	None	-	11	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
		CHEMBL190461	788	39	None	-	11	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
		DB09061	788	39	None	-	11	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
		118422671	2757	65	None	-	4	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
		1887	2757	65	None	-	4	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
		71301	2757	65	None	-	4	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
		7246	2757	65	None	-	4	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
		CHEMBL434394	2757	65	None	-	4	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
		DB04861	2757	65	None	-	4	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
		104850	3330	96	None	-	5	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
		4150	3330	96	None	-	5	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
		743	3330	96	None	-	5	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
		CHEMBL111	3330	96	None	-	5	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
		DB06155	3330	96	None	-	5	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
		3926	207241	40	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	491	9	1	3	5.8	Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1038/s41467-023-40064-9
		CHEMBL92870	207241	40	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	491	9	1	3	5.8	Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1038/s41467-023-40064-9
		156419	938	74	None	-	1	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	357	6	1	1	6.1	C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
		3308	938	74	None	-	1	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	357	6	1	1	6.1	C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
		647	938	74	None	-	1	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	357	6	1	1	6.1	C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
		CHEMBL1201284	938	74	None	-	1	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	357	6	1	1	6.1	C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
		DB01012	938	74	None	-	1	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	357	6	1	1	6.1	C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
		2540	4401	111	None	-	4	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	610	10	1	11	6.3	CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1	10.1038/s41467-023-40064-9
		CHEMBL1014	4401	111	None	-	4	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	610	10	1	11	6.3	CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1	10.1038/s41467-023-40064-9
		135564886	14493	5	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
		135673376	14493	5	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
		137157436	14493	5	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
		145948239	14493	5	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
		71587099	14493	5	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
		CHEMBL1201304	14493	5	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
		51755	57406	54	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	454	8	0	4	7.3	Clc1ccc(C(Cn2ccnc2)OCc2ccc(Sc3ccccc3)cc2)c(Cl)c1	10.1038/s41467-023-40064-9
		CHEMBL1651990	57406	54	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	454	8	0	4	7.3	Clc1ccc(C(Cn2ccnc2)OCc2ccc(Sc3ccccc3)cc2)c(Cl)c1	10.1038/s41467-023-40064-9
		44112	121290	48	None	-	7	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	380	7	2	4	4.5	Cc1cc2c(OCC(CNC(C)(C)C)OC(=O)c3ccccc3)cccc2[nH]1	10.1038/s41467-023-40064-9
		CHEMBL357995	121290	48	None	-	7	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	380	7	2	4	4.5	Cc1cc2c(OCC(CNC(C)(C)C)OC(=O)c3ccccc3)cccc2[nH]1	10.1038/s41467-023-40064-9
		1048	1585	76	None	-	1	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1038/s41467-023-40064-9
		12560	1585	76	None	-	1	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1038/s41467-023-40064-9
		1456	1585	76	None	-	1	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1038/s41467-023-40064-9
		CHEMBL532	1585	76	None	-	1	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1038/s41467-023-40064-9
		DB00199	1585	76	None	-	1	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1038/s41467-023-40064-9
		5282138	173123	95	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	492	10	1	8	4.3	COCCOC(=O)C1=C(C)NC(C)=C(C(=O)OC/C=C/c2ccccc2)C1c1cccc([N+](=O)[O-])c1	10.1038/s41467-023-40064-9
		CHEMBL452076	173123	95	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	492	10	1	8	4.3	COCCOC(=O)C1=C(C)NC(C)=C(C(=O)OC/C=C/c2ccccc2)C1c1cccc([N+](=O)[O-])c1	10.1038/s41467-023-40064-9
		6436173	55116	45	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	785	2	5	13	6.2	CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c5c(nc6cc(C)ccn65)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C	10.1038/s41467-023-40064-9
		CHEMBL1617	55116	45	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	785	2	5	13	6.2	CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c5c(nc6cc(C)ccn65)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C	10.1038/s41467-023-40064-9
		32798	10176	69	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	466	4	1	5	4.1	CCC(=O)O[C@]1(C(=O)CCl)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C	10.1038/s41467-023-40064-9
		CHEMBL1159650	10176	69	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	466	4	1	5	4.1	CCC(=O)O[C@]1(C(=O)CCl)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C	10.1038/s41467-023-40064-9
		16363	596	53	None	-	7	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		312	596	53	None	-	7	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		9215	596	53	None	-	7	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL297302	596	53	None	-	7	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		DB12867	596	53	None	-	7	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		17676	7072	29	None	-	3	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
		5281082	7072	29	None	-	3	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
		CHEMBL1085	7072	29	None	-	3	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
		3401	78283	80	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	346	4	0	2	5.0	Fc1ccc(C(c2ccccc2)(c2ccccc2F)n2ccnc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL2107430	78283	80	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	346	4	0	2	5.0	Fc1ccc(C(c2ccccc2)(c2ccccc2F)n2ccnc2)cc1	10.1038/s41467-023-40064-9
		54682461	84686	62	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	602	11	2	6	7.3	CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)C(=O)O1	10.1038/s41467-023-40064-9
		CHEMBL222559	84686	62	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	602	11	2	6	7.3	CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)C(=O)O1	10.1038/s41467-023-40064-9
		4413	98073	57	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	347	4	5	4	2.6	N=C(N)Nc1ccc(C(=O)Oc2ccc3cc(C(=N)N)ccc3c2)cc1	10.1038/s41467-023-40064-9
		CHEMBL273264	98073	57	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	347	4	5	4	2.6	N=C(N)Nc1ccc(C(=O)Oc2ccc3cc(C(=N)N)ccc3c2)cc1	10.1038/s41467-023-40064-9
		4495	196535	92	None	-	29	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	308	5	1	5	2.8	CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL56367	196535	92	None	-	29	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	308	5	1	5	2.8	CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1	10.1038/s41467-023-40064-9
		2335	11848	22	None	-	12	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
		8478	11848	22	None	-	12	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL1182210	11848	22	None	-	12	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL221753	11848	22	None	-	12	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
		216239	23795	118	None	-	7	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	10.1038/s41467-023-40064-9
		CHEMBL1200485	23795	118	None	-	7	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	10.1038/s41467-023-40064-9
		CHEMBL1336	23795	118	None	-	7	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	10.1038/s41467-023-40064-9
		3474	38101	57	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	372	6	3	6	3.1	O=C(OCC(O)CO)c1ccccc1Nc1ccnc2cc(Cl)ccc12	10.1038/s41467-023-40064-9
		CHEMBL146095	38101	57	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	372	6	3	6	3.1	O=C(OCC(O)CO)c1ccccc1Nc1ccnc2cc(Cl)ccc12	10.1038/s41467-023-40064-9
		169870	14441	67	None	-	1	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	428	6	0	4	6.0	CCCCCC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
		CHEMBL1200848	14441	67	None	-	1	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	428	6	0	4	6.0	CCCCCC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
		216416	111581	48	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	413	6	1	3	5.7	Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
		CHEMBL328190	111581	48	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	413	6	1	3	5.7	Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
		4746	204891	31	None	-	4	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
		CHEMBL1334033	204891	31	None	-	4	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
		CHEMBL75880	204891	31	None	-	4	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
		3149	12614	15	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	334	15	0	1	6.1	CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL1187011	12614	15	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	334	15	0	1	6.1	CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1	10.1038/s41467-023-40064-9
		60065	84369	6	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	505	7	1	8	4.2	COC(=O)C1=C(C)NC(C)=C(C(=O)O[C@@H]2CCCN(Cc3ccccc3)C2)C1c1cccc([N+](=O)[O-])c1	10.1038/s41467-023-40064-9
		CHEMBL2218858	84369	6	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	505	7	1	8	4.2	COC(=O)C1=C(C)NC(C)=C(C(=O)O[C@@H]2CCCN(Cc3ccccc3)C2)C1c1cccc([N+](=O)[O-])c1	10.1038/s41467-023-40064-9
		131411	15392	70	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	476	7	1	6	5.2	CCOC(=O)c1c(CSc2ccccc2)n(C)c2cc(Br)c(O)c(CN(C)C)c12	10.1038/s41467-023-40064-9
		28446253	15392	70	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	476	7	1	6	5.2	CCOC(=O)c1c(CSc2ccccc2)n(C)c2cc(Br)c(O)c(CN(C)C)c12	10.1038/s41467-023-40064-9
		CHEMBL1214598	15392	70	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	476	7	1	6	5.2	CCOC(=O)c1c(CSc2ccccc2)n(C)c2cc(Br)c(O)c(CN(C)C)c12	10.1038/s41467-023-40064-9
		2435	3590	83	None	-	48	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
		60149	3590	83	None	-	48	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
		98	3590	83	None	-	48	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
		CHEMBL12713	3590	83	None	-	48	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
		DB06144	3590	83	None	-	48	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
		11643449	89955	3	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	753	6	5	10	2.7	CC[C@]1(O)C[C@@H]2CN(CCc3c([nH]c4ccccc34)[C@@](C(=O)OC)(c3cc4c(cc3OC)N(C)[C@H]3[C@@](O)(C(N)=O)[C@H](O)[C@]5(CC)C=CCN6CC[C@]43[C@@H]65)C2)C1	10.1038/s41467-023-40064-9
		CHEMBL238071	89955	3	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	753	6	5	10	2.7	CC[C@]1(O)C[C@@H]2CN(CCc3c([nH]c4ccccc34)[C@@](C(=O)OC)(c3cc4c(cc3OC)N(C)[C@H]3[C@@](O)(C(N)=O)[C@H](O)[C@]5(CC)C=CCN6CC[C@]43[C@@H]65)C2)C1	10.1038/s41467-023-40064-9
		202	1508	77	None	-	30	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
		60835	1508	77	None	-	30	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
		972	1508	77	None	-	30	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL1175	1508	77	None	-	30	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
		DB00476	1508	77	None	-	30	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
		72093	35061	9	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
		CHEMBL1433361	35061	9	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
		CHEMBL2103773	35061	9	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
		25077405	2715	0	None	-	1	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
		3902	2715	0	None	-	1	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
		CHEMBL1201309	2715	0	None	-	1	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
		DB00666	2715	0	None	-	1	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
		2247	505	81	None	-	42	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		249	505	81	None	-	42	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		2603	505	81	None	-	42	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		CHEMBL296419	505	81	None	-	42	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		DB00637	505	81	None	-	42	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		148192	10420	81	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	704	14	5	9	4.2	COC(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)CN(Cc1ccc(-c2ccccn2)cc1)NC(=O)[C@@H](NC(=O)OC)C(C)(C)C)C(C)(C)C	10.1038/s41467-023-40064-9
		CHEMBL1163	10420	81	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	704	14	5	9	4.2	COC(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)CN(Cc1ccc(-c2ccccn2)cc1)NC(=O)[C@@H](NC(=O)OC)C(C)(C)C)C(C)(C)C	10.1038/s41467-023-40064-9
		71496458	115564	87	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	499	10	2	8	4.5	C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C	10.1038/s41467-023-40064-9
		CHEMBL3353410	115564	87	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	499	10	2	8	4.5	C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C	10.1038/s41467-023-40064-9
		65016	10209	86	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	505	11	3	7	2.4	CC(C)CN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)O[C@H]1CCOC1)S(=O)(=O)c1ccc(N)cc1	10.1038/s41467-023-40064-9
		CHEMBL116	10209	86	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	505	11	3	7	2.4	CC(C)CN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)O[C@H]1CCOC1)S(=O)(=O)c1ccc(N)cc1	10.1038/s41467-023-40064-9
		5329102	194726	86	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	398	7	3	3	3.3	CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C	10.1038/s41467-023-40064-9
		CHEMBL535	194726	86	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	398	7	3	3	3.3	CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C	10.1038/s41467-023-40064-9
		2585	803	103	None	-	21	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
		522	803	103	None	-	21	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
		551	803	103	None	-	21	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
		CHEMBL723	803	103	None	-	21	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
		DB01136	803	103	None	-	21	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
		444029	167757	10	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	509	6	2	9	2.0	C=C[C@@]1(C)CC(=O)[C@]2(O)[C@@]3(C)[C@@H](O)CCC(C)(C)[C@@H]3[C@H](OC(=O)CCN(C)C)[C@H](OC(C)=O)[C@@]2(C)O1	10.1038/s41467-023-40064-9
		CHEMBL4303178	167757	10	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	509	6	2	9	2.0	C=C[C@@]1(C)CC(=O)[C@]2(O)[C@@]3(C)[C@@H](O)CCC(C)(C)[C@@H]3[C@H](OC(=O)CCN(C)C)[C@H](OC(C)=O)[C@@]2(C)O1	10.1038/s41467-023-40064-9
		2713	205271	82	None	-	0	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		5353524	205271	82	None	-	0	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		5360566	205271	82	None	-	0	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		88536661	205271	82	None	-	0	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		9552079	205271	82	None	-	0	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		CHEMBL1330113	205271	82	None	-	0	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		CHEMBL790	205271	82	None	-	0	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		214	3860	58	None	-	30	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		2740	3860	58	None	-	30	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		5566	3860	58	None	-	30	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		66064	3860	58	None	-	30	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		CHEMBL422	3860	58	None	-	30	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		DB00831	3860	58	None	-	30	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		68867	78173	38	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	402	7	2	6	3.1	CCOc1cc(N)c([N+](=O)[O-])cc1C(=O)NC1CCN(CC2CC=CCC2)CC1	10.1038/s41467-023-40064-9
		CHEMBL2104523	78173	38	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	402	7	2	6	3.1	CCOc1cc(N)c([N+](=O)[O-])cc1C(=O)NC1CCN(CC2CC=CCC2)CC1	10.1038/s41467-023-40064-9
		11980903	14492	19	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	382	4	0	2	5.3	Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1	10.1038/s41467-023-40064-9
		22526	14492	19	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	382	4	0	2	5.3	Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1	10.1038/s41467-023-40064-9
		5281035	14492	19	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	382	4	0	2	5.3	Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL1201303	14492	19	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	382	4	0	2	5.3	Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1	10.1038/s41467-023-40064-9
		242	470	124	None	-	51	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		34	470	124	None	-	51	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		60795	470	124	None	-	51	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		CHEMBL1112	470	124	None	-	51	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		DB01238	470	124	None	-	51	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		139592915	3374	35	None	-	1	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	837	13	5	17	2.2	COCCOCO/N=C/1\[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@H](C)[C@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C(=O)O[C@@H]([C@@]([C@@H]([C@H]1C)O)(C)O)CC)C	10.1038/s41467-023-40064-9
		1465	3374	35	None	-	1	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	837	13	5	17	2.2	COCCOCO/N=C/1\[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@H](C)[C@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C(=O)O[C@@H]([C@@]([C@@H]([C@H]1C)O)(C)O)CC)C	10.1038/s41467-023-40064-9
		2410	3374	35	None	-	1	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	837	13	5	17	2.2	COCCOCO/N=C/1\[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@H](C)[C@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C(=O)O[C@@H]([C@@]([C@@H]([C@H]1C)O)(C)O)CC)C	10.1038/s41467-023-40064-9
		6915744	3374	35	None	-	1	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	837	13	5	17	2.2	COCCOCO/N=C/1\[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@H](C)[C@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C(=O)O[C@@H]([C@@]([C@@H]([C@H]1C)O)(C)O)CC)C	10.1038/s41467-023-40064-9
		CHEMBL1214185	3374	35	None	-	1	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	837	13	5	17	2.2	COCCOCO/N=C/1\[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@H](C)[C@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C(=O)O[C@@H]([C@@]([C@@H]([C@H]1C)O)(C)O)CC)C	10.1038/s41467-023-40064-9
		DB00778	3374	35	None	-	1	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	837	13	5	17	2.2	COCCOCO/N=C/1\[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@H](C)[C@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C(=O)O[C@@H]([C@@]([C@@H]([C@H]1C)O)(C)O)CC)C	10.1038/s41467-023-40064-9
		445643	97389	69	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	803	7	3	12	4.6	C=CC[C@@H]1/C=C(\C)C[C@H](C)C[C@H](OC)[C@H]2O[C@@](O)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@H](/C(C)=C/[C@@H]3CC[C@@H](O)[C@H](OC)C3)[C@H](C)[C@@H](O)CC1=O)[C@H](C)C[C@@H]2OC	10.1038/s41467-023-40064-9
		CHEMBL269732	97389	69	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	803	7	3	12	4.6	C=CC[C@@H]1/C=C(\C)C[C@H](C)C[C@H](OC)[C@H]2O[C@@](O)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@H](/C(C)=C/[C@@H]3CC[C@@H](O)[C@H](OC)C3)[C@H](C)[C@@H](O)CC1=O)[C@H](C)C[C@@H]2OC	10.1038/s41467-023-40064-9
		1222	1664	49	None	-	33	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
		3396	1664	49	None	-	33	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
		85	1664	49	None	-	33	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL46516	1664	49	None	-	33	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
		DB04842	1664	49	None	-	33	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MLNR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
		16752689	188368	0	None	-	0	Human	8.0	pEC50	=	8	Binding	Agonist activity at MLNR (unknown origin)Agonist activity at MLNR (unknown origin)	ChEMBL	568	10	2	4	6.6	COc1cccc(CCN(Cc2ccccc2-c2ccc(CN3C[C@H](C)N[C@H](C)C3)cc2)C(=O)NC2CCCCC2)c1	10.1021/jm301653f
		CHEMBL501315	188368	0	None	-	0	Human	8.0	pEC50	=	8	Binding	Agonist activity at MLNR (unknown origin)Agonist activity at MLNR (unknown origin)	ChEMBL	568	10	2	4	6.6	COc1cccc(CCN(Cc2ccccc2-c2ccc(CN3C[C@H](C)N[C@H](C)C3)cc2)C(=O)NC2CCCCC2)c1	10.1021/jm301653f
		CHEMBL496391	214083	0	None	-	1	Rabbit	9.0	pIC50	=	9.0	Binding	Displacement of [125I]motilin from MTL receptor in rabbit duodenum homogenateDisplacement of [125I]motilin from MTL receptor in rabbit duodenum homogenate	ChEMBL		None	None	None		CC(C)[C@@H](C(=O)N[C@@H](Cc1ccc(O)c(C(C)(C)C)c1)C(N)=O)N(C)C(=O)[C@@H](N)Cc1ccccc1	10.1016/j.bmcl.2009.05.059
		11018075	100388	0	None	-	0	Rabbit	8.8	pIC50	=	8.8	Binding	In vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tissue homogenate	ChEMBL	739	9	1	12	5.6	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)CC(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC	10.1016/S0960-894X(01)80583-7
		CHEMBL289955	100388	0	None	-	0	Rabbit	8.8	pIC50	=	8.8	Binding	In vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tissue homogenate	ChEMBL	739	9	1	12	5.6	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)CC(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC	10.1016/S0960-894X(01)80583-7
		44290233	172826	0	None	-	0	Rabbit	8.7	pIC50	=	8.7	Binding	In vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenate	ChEMBL	723	9	0	11	6.6	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)CC(C)O2)C(C)[C@@H](OC2CC(N(C)C(C)C)CC(C)O2)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC	10.1016/S0960-894X(01)80583-7
		CHEMBL45141	172826	0	None	-	0	Rabbit	8.7	pIC50	=	8.7	Binding	In vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenate	ChEMBL	723	9	0	11	6.6	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)CC(C)O2)C(C)[C@@H](OC2CC(N(C)C(C)C)CC(C)O2)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC	10.1016/S0960-894X(01)80583-7
		9956253	187841	0	None	-	1	Rabbit	8.7	pIC50	=	8.7	Binding	Displacement of [125I]motilin from MTL receptor in rabbit duodenum homogenateDisplacement of [125I]motilin from MTL receptor in rabbit duodenum homogenate	ChEMBL	467	9	3	4	3.8	CC(C)[C@@H](C(=O)N[C@H](C)Cc1ccc(O)c(C(C)(C)C)c1)N(C)C(=O)[C@@H](N)Cc1ccccc1	10.1016/j.bmcl.2009.05.059
		CHEMBL496191	187841	0	None	-	1	Rabbit	8.7	pIC50	=	8.7	Binding	Displacement of [125I]motilin from MTL receptor in rabbit duodenum homogenateDisplacement of [125I]motilin from MTL receptor in rabbit duodenum homogenate	ChEMBL	467	9	3	4	3.8	CC(C)[C@@H](C(=O)N[C@H](C)Cc1ccc(O)c(C(C)(C)C)c1)N(C)C(=O)[C@@H](N)Cc1ccccc1	10.1016/j.bmcl.2009.05.059
		9895192	77855	0	None	-	0	Rabbit	8.0	pIC50	=	8	Binding	Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor	ChEMBL	613	11	0	4	7.6	CC(C)(C)C(=O)N(Cc1ccccc1)[C@@H]1CCC[C@H](CN(C(=O)c2ccc(F)cc2)c2cccc(OCCN3CCCC3)c2)C1	10.1016/j.bmcl.2006.04.017
		CHEMBL209301	77855	0	None	-	0	Rabbit	8.0	pIC50	=	8	Binding	Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor	ChEMBL	613	11	0	4	7.6	CC(C)(C)C(=O)N(Cc1ccccc1)[C@@H]1CCC[C@H](CN(C(=O)c2ccc(F)cc2)c2cccc(OCCN3CCCC3)c2)C1	10.1016/j.bmcl.2006.04.017
		44412981	138340	0	None	-	0	Rabbit	8.0	pIC50	=	8	Binding	Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor	ChEMBL	704	11	2	5	7.3	O=C(Nc1ccccc1)N(CC1=C[C@@](Cc2cccc(Cl)c2)(NC(=O)C(Cl)(Cl)Cl)CC1)c1cccc(OCCN2CCOCC2)c1	10.1016/j.bmcl.2006.04.017
		CHEMBL377137	138340	0	None	-	0	Rabbit	8.0	pIC50	=	8	Binding	Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor	ChEMBL	704	11	2	5	7.3	O=C(Nc1ccccc1)N(CC1=C[C@@](Cc2cccc(Cl)c2)(NC(=O)C(Cl)(Cl)Cl)CC1)c1cccc(OCCN2CCOCC2)c1	10.1016/j.bmcl.2006.04.017
		1466	1828	0	None	-	0	Rabbit	8.0	pIC50	=	8	Binding	Inhibition of the motilin receptor (MTL-R)Inhibition of the motilin receptor (MTL-R)	ChEMBL		None	None	None		None	10.1021/jm010332u
		9850904	1828	0	None	-	0	Rabbit	8.0	pIC50	=	8	Binding	Inhibition of the motilin receptor (MTL-R)Inhibition of the motilin receptor (MTL-R)	ChEMBL		None	None	None		None	10.1021/jm010332u
		CHEMBL3143516	1828	0	None	-	0	Rabbit	8.0	pIC50	=	8	Binding	Inhibition of the motilin receptor (MTL-R)Inhibition of the motilin receptor (MTL-R)	ChEMBL		None	None	None		None	10.1021/jm010332u
		10122749	78312	0	None	-	0	Rabbit	5.9	pIC50	=	5.9	Binding	Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor	ChEMBL	691	13	1	7	7.2	O=C(Nc1ccccc1)N(CC1CCCC(N(Cc2ccccc2)C(=O)c2cccc([N+](=O)[O-])c2)C1)c1cccc(OCCN2CCOCC2)c1	10.1016/j.bmcl.2006.04.017
		CHEMBL210899	78312	0	None	-	0	Rabbit	5.9	pIC50	=	5.9	Binding	Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor	ChEMBL	691	13	1	7	7.2	O=C(Nc1ccccc1)N(CC1CCCC(N(Cc2ccccc2)C(=O)c2cccc([N+](=O)[O-])c2)C1)c1cccc(OCCN2CCOCC2)c1	10.1016/j.bmcl.2006.04.017
		44583286	193450	0	None	-	1	Rabbit	7.9	pIC50	=	7.9	Binding	Displacement of [125I]motilin from MTL receptor in rabbit duodenum homogenateDisplacement of [125I]motilin from MTL receptor in rabbit duodenum homogenate	ChEMBL	564	6	5	6	2.8	CC(C)(C)c1cc(C[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H](N)Cc3ccccc3)CCCCCC(=O)CCNC2=O)ccc1O	10.1016/j.bmcl.2009.05.059
		CHEMBL526496	193450	0	None	-	1	Rabbit	7.9	pIC50	=	7.9	Binding	Displacement of [125I]motilin from MTL receptor in rabbit duodenum homogenateDisplacement of [125I]motilin from MTL receptor in rabbit duodenum homogenate	ChEMBL	564	6	5	6	2.8	CC(C)(C)c1cc(C[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H](N)Cc3ccccc3)CCCCCC(=O)CCNC2=O)ccc1O	10.1016/j.bmcl.2009.05.059
		CHEMBL497004	214084	0	None	-	1	Rabbit	7.9	pIC50	=	7.9	Binding	Displacement of [125I]motilin from MTL receptor in rabbit duodenum homogenateDisplacement of [125I]motilin from MTL receptor in rabbit duodenum homogenate	ChEMBL		None	None	None		CC(C)(C)c1cc(C[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccccc2)c2ccccc2)C(N)=O)ccc1O	10.1016/j.bmcl.2009.05.059
		44412894	138910	0	None	-	0	Rabbit	7.9	pIC50	=	7.9	Binding	Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor	ChEMBL	718	12	0	6	7.8	O=C(c1ccc(F)cc1)N(CC1CCCC(N(Cc2cccc([N+](=O)[O-])c2)C(=O)C(Cl)(Cl)Cl)C1)c1cccc(OCCN2CCCC2)c1	10.1016/j.bmcl.2006.04.017
		CHEMBL378317	138910	0	None	-	0	Rabbit	7.9	pIC50	=	7.9	Binding	Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor	ChEMBL	718	12	0	6	7.8	O=C(c1ccc(F)cc1)N(CC1CCCC(N(Cc2cccc([N+](=O)[O-])c2)C(=O)C(Cl)(Cl)Cl)C1)c1cccc(OCCN2CCCC2)c1	10.1016/j.bmcl.2006.04.017
		44380651	120132	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)	ChEMBL	757	9	3	13	4.3	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)OC	10.1016/0960-894X(95)00122-A
		CHEMBL351216	120132	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)	ChEMBL	757	9	3	13	4.3	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)OC	10.1016/0960-894X(95)00122-A
		44276703	99284	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Compound was tested for in vitro motilin receptor binding affinityCompound was tested for in vitro motilin receptor binding affinity	ChEMBL	715	7	3	13	3.0	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@]2(C)CC(C)C3(O2)O[C@]1(C)[C@H](O)[C@H]3C	10.1016/0960-894X(95)00122-A
		CHEMBL281952	99284	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Compound was tested for in vitro motilin receptor binding affinityCompound was tested for in vitro motilin receptor binding affinity	ChEMBL	715	7	3	13	3.0	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@]2(C)CC(C)C3(O2)O[C@]1(C)[C@H](O)[C@H]3C	10.1016/0960-894X(95)00122-A
		44276703	99284	0	None	-	0	Rabbit	6.8	pIC50	=	6.8	Binding	Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50	ChEMBL	715	7	3	13	3.0	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@]2(C)CC(C)C3(O2)O[C@]1(C)[C@H](O)[C@H]3C	10.1016/S0960-894X(01)80359-0
		CHEMBL281952	99284	0	None	-	0	Rabbit	6.8	pIC50	=	6.8	Binding	Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50	ChEMBL	715	7	3	13	3.0	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@]2(C)CC(C)C3(O2)O[C@]1(C)[C@H](O)[C@H]3C	10.1016/S0960-894X(01)80359-0
		44276703	99284	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)	ChEMBL	715	7	3	13	3.0	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@]2(C)CC(C)C3(O2)O[C@]1(C)[C@H](O)[C@H]3C	10.1016/0960-894X(95)00122-A
		CHEMBL281952	99284	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)	ChEMBL	715	7	3	13	3.0	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@]2(C)CC(C)C3(O2)O[C@]1(C)[C@H](O)[C@H]3C	10.1016/0960-894X(95)00122-A
		44276703	99284	0	None	-	0	Rabbit	6.8	pIC50	=	6.8	Binding	Concentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor bindingConcentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor binding	ChEMBL	715	7	3	13	3.0	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@]2(C)CC(C)C3(O2)O[C@]1(C)[C@H](O)[C@H]3C	10.1016/S0960-894X(01)80359-0
		CHEMBL281952	99284	0	None	-	0	Rabbit	6.8	pIC50	=	6.8	Binding	Concentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor bindingConcentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor binding	ChEMBL	715	7	3	13	3.0	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@]2(C)CC(C)C3(O2)O[C@]1(C)[C@H](O)[C@H]3C	10.1016/S0960-894X(01)80359-0
		11767227	106691	0	None	-	0	Rabbit	7.8	pIC50	=	7.8	Binding	Inhibition of the motilin receptor (MTL-R)Inhibition of the motilin receptor (MTL-R)	ChEMBL	607	6	6	6	2.7	CC(C)(C)c1cc(C[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H](N)Cc3ccccc3)CCCCNC(=O)CCCCCNC2=O)ccc1O	10.1021/jm010332u
		CHEMBL3143521	106691	0	None	-	0	Rabbit	7.8	pIC50	=	7.8	Binding	Inhibition of the motilin receptor (MTL-R)Inhibition of the motilin receptor (MTL-R)	ChEMBL	607	6	6	6	2.7	CC(C)(C)c1cc(C[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H](N)Cc3ccccc3)CCCCNC(=O)CCCCCNC2=O)ccc1O	10.1021/jm010332u
		10940742	115415	0	None	-	0	Rabbit	5.8	pIC50	=	5.8	Binding	Inhibition of the motilin receptor (MTL-R)Inhibition of the motilin receptor (MTL-R)	ChEMBL	565	6	6	6	1.6	CC(C)(C)c1cc(C[C@@H]2NC(=O)[C@@H](NC(=O)[C@H](N)Cc3ccccc3)CCCCNC(=O)CCNC2=O)ccc1O	10.1021/jm010332u
		CHEMBL3350348	115415	0	None	-	0	Rabbit	5.8	pIC50	=	5.8	Binding	Inhibition of the motilin receptor (MTL-R)Inhibition of the motilin receptor (MTL-R)	ChEMBL	565	6	6	6	1.6	CC(C)(C)c1cc(C[C@@H]2NC(=O)[C@@H](NC(=O)[C@H](N)Cc3ccccc3)CCCCNC(=O)CCNC2=O)ccc1O	10.1021/jm010332u
		CHEMBL524083	215600	0	None	-	0	Rabbit	6.7	pIC50	=	6.7	Binding	Displacement of [125I]motilin from MTL receptor in rabbit duodenum homogenateDisplacement of [125I]motilin from MTL receptor in rabbit duodenum homogenate	ChEMBL		None	None	None		C[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)c(C(C)(C)C)c1)C(N)=O	10.1016/j.bmcl.2009.05.059
		44290232	101384	0	None	-	0	Rabbit	8.6	pIC50	=	8.6	Binding	In vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenate	ChEMBL	711	8	1	12	4.8	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)CC(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC	10.1016/S0960-894X(01)80583-7
		CHEMBL297168	101384	0	None	-	0	Rabbit	8.6	pIC50	=	8.6	Binding	In vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenate	ChEMBL	711	8	1	12	4.8	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)CC(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC	10.1016/S0960-894X(01)80583-7
		11018075	100388	0	None	-	0	Rabbit	8.6	pIC50	=	8.6	Binding	In vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenate	ChEMBL	739	9	1	12	5.6	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)CC(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC	10.1016/S0960-894X(01)80583-7
		CHEMBL289955	100388	0	None	-	0	Rabbit	8.6	pIC50	=	8.6	Binding	In vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenate	ChEMBL	739	9	1	12	5.6	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)CC(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC	10.1016/S0960-894X(01)80583-7
		9809991	139522	0	None	-	0	Rabbit	7.7	pIC50	=	7.7	Binding	Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor	ChEMBL	670	11	2	5	6.6	O=C(Nc1ccccc1)N(CC1=C[C@@](Cc2ccccc2)(NC(=O)C(Cl)(Cl)Cl)CC1)c1cccc(OCCN2CCOCC2)c1	10.1016/j.bmcl.2006.04.017
		CHEMBL379519	139522	0	None	-	0	Rabbit	7.7	pIC50	=	7.7	Binding	Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor	ChEMBL	670	11	2	5	6.6	O=C(Nc1ccccc1)N(CC1=C[C@@](Cc2ccccc2)(NC(=O)C(Cl)(Cl)Cl)CC1)c1cccc(OCCN2CCOCC2)c1	10.1016/j.bmcl.2006.04.017
		10211030	77745	0	None	-	0	Rabbit	7.7	pIC50	=	7.7	Binding	Inhibition of [125]I-motilin binding to rabbit motilin receptor at 1 uMInhibition of [125]I-motilin binding to rabbit motilin receptor at 1 uM	ChEMBL	610	11	1	4	7.8	CC(C)(C)C(=O)N(Cc1ccccc1)C1CCCC(CN(C(=O)Nc2ccccc2)c2cccc(OCCN3CCCC3)c2)C1	10.1016/j.bmcl.2006.04.017
		CHEMBL209024	77745	0	None	-	0	Rabbit	7.7	pIC50	=	7.7	Binding	Inhibition of [125]I-motilin binding to rabbit motilin receptor at 1 uMInhibition of [125]I-motilin binding to rabbit motilin receptor at 1 uM	ChEMBL	610	11	1	4	7.8	CC(C)(C)C(=O)N(Cc1ccccc1)C1CCCC(CN(C(=O)Nc2ccccc2)c2cccc(OCCN3CCCC3)c2)C1	10.1016/j.bmcl.2006.04.017
		44374025	52180	0	None	-	0	Rabbit	5.7	pIC50	=	5.7	Binding	Inhibition of the motilin receptor (MTL-R)Inhibition of the motilin receptor (MTL-R)	ChEMBL	565	6	6	6	1.6	CC(C)(C)c1cc(CC2NC(=O)[C@@H](NC(=O)C(N)Cc3ccccc3)CCCCNC(=O)CCNC2=O)ccc1O	10.1021/jm010332u
		CHEMBL158821	52180	0	None	-	0	Rabbit	5.7	pIC50	=	5.7	Binding	Inhibition of the motilin receptor (MTL-R)Inhibition of the motilin receptor (MTL-R)	ChEMBL	565	6	6	6	1.6	CC(C)(C)c1cc(CC2NC(=O)[C@@H](NC(=O)C(N)Cc3ccccc3)CCCCNC(=O)CCNC2=O)ccc1O	10.1021/jm010332u
		1448	2479	34	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)	ChEMBL	715	7	4	13	2.9	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@H]([C@@]2(OC(=C(C)C2)[C@@H]([C@H]([C@]1(C)O)O)C)C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C)C	10.1016/0960-894X(95)00122-A
		83954	2479	34	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)	ChEMBL	715	7	4	13	2.9	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@H]([C@@]2(OC(=C(C)C2)[C@@H]([C@H]([C@]1(C)O)O)C)C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C)C	10.1016/0960-894X(95)00122-A
		CHEMBL300004	2479	34	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)	ChEMBL	715	7	4	13	2.9	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@H]([C@@]2(OC(=C(C)C2)[C@@H]([C@H]([C@]1(C)O)O)C)C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C)C	10.1016/0960-894X(95)00122-A
		1448	2479	34	None	-	0	Rabbit	6.7	pIC50	=	6.7	Binding	Concentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor bindingConcentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor binding	ChEMBL	715	7	4	13	2.9	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@H]([C@@]2(OC(=C(C)C2)[C@@H]([C@H]([C@]1(C)O)O)C)C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C)C	10.1016/S0960-894X(01)80359-0
		83954	2479	34	None	-	0	Rabbit	6.7	pIC50	=	6.7	Binding	Concentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor bindingConcentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor binding	ChEMBL	715	7	4	13	2.9	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@H]([C@@]2(OC(=C(C)C2)[C@@H]([C@H]([C@]1(C)O)O)C)C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C)C	10.1016/S0960-894X(01)80359-0
		CHEMBL300004	2479	34	None	-	0	Rabbit	6.7	pIC50	=	6.7	Binding	Concentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor bindingConcentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor binding	ChEMBL	715	7	4	13	2.9	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@H]([C@@]2(OC(=C(C)C2)[C@@H]([C@H]([C@]1(C)O)O)C)C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C)C	10.1016/S0960-894X(01)80359-0
		44583347	187820	0	None	-	1	Rabbit	7.6	pIC50	=	7.6	Binding	Displacement of [125I]motilin from MTL receptor in rabbit duodenum homogenateDisplacement of [125I]motilin from MTL receptor in rabbit duodenum homogenate	ChEMBL	496	10	4	5	2.3	CC(C)[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N(C)[C@@H](Cc1ccc(O)c(C(C)(C)C)c1)C(N)=O	10.1016/j.bmcl.2009.05.059
		CHEMBL495994	187820	0	None	-	1	Rabbit	7.6	pIC50	=	7.6	Binding	Displacement of [125I]motilin from MTL receptor in rabbit duodenum homogenateDisplacement of [125I]motilin from MTL receptor in rabbit duodenum homogenate	ChEMBL	496	10	4	5	2.3	CC(C)[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N(C)[C@@H](Cc1ccc(O)c(C(C)(C)C)c1)C(N)=O	10.1016/j.bmcl.2009.05.059
		11081770	89459	0	None	-	0	Rabbit	4.6	pIC50	=	4.6	Binding	Inhibition of the motilin receptor (MTL-R)Inhibition of the motilin receptor (MTL-R)	ChEMBL	509	6	6	6	0.3	N[C@@H](Cc1ccccc1)C(=O)N[C@H]1CCCCNC(=O)CCNC(=O)[C@H](Cc2ccc(O)cc2)NC1=O	10.1021/jm010332u
		CHEMBL2371260	89459	0	None	-	0	Rabbit	4.6	pIC50	=	4.6	Binding	Inhibition of the motilin receptor (MTL-R)Inhibition of the motilin receptor (MTL-R)	ChEMBL	509	6	6	6	0.3	N[C@@H](Cc1ccccc1)C(=O)N[C@H]1CCCCNC(=O)CCNC(=O)[C@H](Cc2ccc(O)cc2)NC1=O	10.1021/jm010332u
		CHEMBL496390	214082	0	None	-	1	Rabbit	7.6	pIC50	=	7.6	Binding	Displacement of [125I]motilin from MTL receptor in rabbit duodenum homogenateDisplacement of [125I]motilin from MTL receptor in rabbit duodenum homogenate	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)c(C(C)(C)C)c1)C(N)=O	10.1016/j.bmcl.2009.05.059
		23557218	139556	0	None	-	0	Rabbit	7.5	pIC50	=	7.5	Binding	Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor	ChEMBL	613	11	0	4	7.6	CC(C)(C)C(=O)N(Cc1ccccc1)C1CCCC(CN(C(=O)c2ccc(F)cc2)c2cccc(OCCN3CCCC3)c2)C1	10.1016/j.bmcl.2006.04.017
		CHEMBL379665	139556	0	None	-	0	Rabbit	7.5	pIC50	=	7.5	Binding	Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor	ChEMBL	613	11	0	4	7.6	CC(C)(C)C(=O)N(Cc1ccccc1)C1CCCC(CN(C(=O)c2ccc(F)cc2)c2cccc(OCCN3CCCC3)c2)C1	10.1016/j.bmcl.2006.04.017
		44380970	120400	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Compound was tested for in vitro motilin receptor binding affinityCompound was tested for in vitro motilin receptor binding affinity	ChEMBL	715	8	4	13	3.0	CCC1OC(=O)C(C)C(OC2C[C@@](C)(OC)[C@@H](O)C(C)O2)C[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/0960-894X(95)00122-A
		CHEMBL353526	120400	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Compound was tested for in vitro motilin receptor binding affinityCompound was tested for in vitro motilin receptor binding affinity	ChEMBL	715	8	4	13	3.0	CCC1OC(=O)C(C)C(OC2C[C@@](C)(OC)[C@@H](O)C(C)O2)C[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/0960-894X(95)00122-A
		44276737	97378	0	None	-	0	Rabbit	8.5	pIC50	=	8.5	Binding	Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50	ChEMBL	729	8	4	13	3.3	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/S0960-894X(01)80359-0
		CHEMBL26966	97378	0	None	-	0	Rabbit	8.5	pIC50	=	8.5	Binding	Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50	ChEMBL	729	8	4	13	3.3	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/S0960-894X(01)80359-0
		44276737	97378	0	None	-	0	Rabbit	8.5	pIC50	=	8.5	Binding	In vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenate	ChEMBL	729	8	4	13	3.3	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/S0960-894X(01)80583-7
		CHEMBL26966	97378	0	None	-	0	Rabbit	8.5	pIC50	=	8.5	Binding	In vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenate	ChEMBL	729	8	4	13	3.3	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/S0960-894X(01)80583-7
		1448	2479	34	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Compound was tested for in vitro motilin receptor binding affinityCompound was tested for in vitro motilin receptor binding affinity	ChEMBL	715	7	4	13	2.9	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@H]([C@@]2(OC(=C(C)C2)[C@@H]([C@H]([C@]1(C)O)O)C)C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C)C	10.1016/0960-894X(95)00122-A
		83954	2479	34	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Compound was tested for in vitro motilin receptor binding affinityCompound was tested for in vitro motilin receptor binding affinity	ChEMBL	715	7	4	13	2.9	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@H]([C@@]2(OC(=C(C)C2)[C@@H]([C@H]([C@]1(C)O)O)C)C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C)C	10.1016/0960-894X(95)00122-A
		CHEMBL300004	2479	34	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Compound was tested for in vitro motilin receptor binding affinityCompound was tested for in vitro motilin receptor binding affinity	ChEMBL	715	7	4	13	2.9	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@H]([C@@]2(OC(=C(C)C2)[C@@H]([C@H]([C@]1(C)O)O)C)C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C)C	10.1016/0960-894X(95)00122-A
		1448	2479	34	None	-	0	Rabbit	8.5	pIC50	=	8.5	Binding	Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50	ChEMBL	715	7	4	13	2.9	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@H]([C@@]2(OC(=C(C)C2)[C@@H]([C@H]([C@]1(C)O)O)C)C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C)C	10.1016/S0960-894X(01)80359-0
		83954	2479	34	None	-	0	Rabbit	8.5	pIC50	=	8.5	Binding	Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50	ChEMBL	715	7	4	13	2.9	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@H]([C@@]2(OC(=C(C)C2)[C@@H]([C@H]([C@]1(C)O)O)C)C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C)C	10.1016/S0960-894X(01)80359-0
		CHEMBL300004	2479	34	None	-	0	Rabbit	8.5	pIC50	=	8.5	Binding	Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50	ChEMBL	715	7	4	13	2.9	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@H]([C@@]2(OC(=C(C)C2)[C@@H]([C@H]([C@]1(C)O)O)C)C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C)C	10.1016/S0960-894X(01)80359-0
		44290012	168161	0	None	-	0	Rabbit	8.5	pIC50	=	8.5	Binding	In vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenate	ChEMBL	725	9	1	12	5.2	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)CC(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC	10.1016/S0960-894X(01)80583-7
		CHEMBL43313	168161	0	None	-	0	Rabbit	8.5	pIC50	=	8.5	Binding	In vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenate	ChEMBL	725	9	1	12	5.2	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)CC(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC	10.1016/S0960-894X(01)80583-7
		44276779	96871	0	None	-	0	Rabbit	8.4	pIC50	=	8.4	Binding	Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50	ChEMBL	741	9	2	13	4.1	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC	10.1016/S0960-894X(01)80359-0
		CHEMBL265495	96871	0	None	-	0	Rabbit	8.4	pIC50	=	8.4	Binding	Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50	ChEMBL	741	9	2	13	4.1	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC	10.1016/S0960-894X(01)80359-0
		44290012	168161	0	None	-	0	Rabbit	8.4	pIC50	=	8.4	Binding	In vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tissue homogenate	ChEMBL	725	9	1	12	5.2	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)CC(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC	10.1016/S0960-894X(01)80583-7
		CHEMBL43313	168161	0	None	-	0	Rabbit	8.4	pIC50	=	8.4	Binding	In vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tissue homogenate	ChEMBL	725	9	1	12	5.2	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)CC(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC	10.1016/S0960-894X(01)80583-7
		44276779	96871	0	None	-	0	Rabbit	8.4	pIC50	=	8.4	Binding	In vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenate	ChEMBL	741	9	2	13	4.1	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC	10.1016/S0960-894X(01)80583-7
		CHEMBL265495	96871	0	None	-	0	Rabbit	8.4	pIC50	=	8.4	Binding	In vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenate	ChEMBL	741	9	2	13	4.1	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC	10.1016/S0960-894X(01)80583-7
		44290232	101384	0	None	-	0	Rabbit	8.4	pIC50	=	8.4	Binding	In vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tissue homogenate	ChEMBL	711	8	1	12	4.8	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)CC(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC	10.1016/S0960-894X(01)80583-7
		CHEMBL297168	101384	0	None	-	0	Rabbit	8.4	pIC50	=	8.4	Binding	In vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tissue homogenate	ChEMBL	711	8	1	12	4.8	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)CC(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC	10.1016/S0960-894X(01)80583-7
		177964	2544	2	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Antagonist activity at MLNR (unknown origin)Antagonist activity at MLNR (unknown origin)	ChEMBL	755	9	2	13	4.5	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@H]([C@]2(OC(=C(C)C2)[C@@H](C(=O)[C@]1(C)OC)C)C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C(C)C)C	10.1021/jm301653f
		3511	2544	2	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Antagonist activity at MLNR (unknown origin)Antagonist activity at MLNR (unknown origin)	ChEMBL	755	9	2	13	4.5	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@H]([C@]2(OC(=C(C)C2)[C@@H](C(=O)[C@]1(C)OC)C)C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C(C)C)C	10.1021/jm301653f
		CHEMBL1778156	2544	2	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Antagonist activity at MLNR (unknown origin)Antagonist activity at MLNR (unknown origin)	ChEMBL	755	9	2	13	4.5	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@H]([C@]2(OC(=C(C)C2)[C@@H](C(=O)[C@]1(C)OC)C)C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C(C)C)C	10.1021/jm301653f
		16040587	179384	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Antagonist activity at MLNR (unknown origin)Antagonist activity at MLNR (unknown origin)	ChEMBL	501	6	2	5	4.8	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1	10.1021/jm301653f
		CHEMBL473921	179384	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Antagonist activity at MLNR (unknown origin)Antagonist activity at MLNR (unknown origin)	ChEMBL	501	6	2	5	4.8	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1	10.1021/jm301653f
		44380970	120400	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)	ChEMBL	715	8	4	13	3.0	CCC1OC(=O)C(C)C(OC2C[C@@](C)(OC)[C@@H](O)C(C)O2)C[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/0960-894X(95)00122-A
		CHEMBL353526	120400	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)	ChEMBL	715	8	4	13	3.0	CCC1OC(=O)C(C)C(OC2C[C@@](C)(OC)[C@@H](O)C(C)O2)C[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/0960-894X(95)00122-A
		44276737	97378	0	None	-	0	Rabbit	6.5	pIC50	=	6.5	Binding	Concentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor bindingConcentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor binding	ChEMBL	729	8	4	13	3.3	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/S0960-894X(01)80359-0
		CHEMBL26966	97378	0	None	-	0	Rabbit	6.5	pIC50	=	6.5	Binding	Concentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor bindingConcentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor binding	ChEMBL	729	8	4	13	3.3	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/S0960-894X(01)80359-0
		44276737	97378	0	None	-	0	Rabbit	6.5	pIC50	=	6.5	Binding	In vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tissue homogenate	ChEMBL	729	8	4	13	3.3	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/S0960-894X(01)80583-7
		CHEMBL26966	97378	0	None	-	0	Rabbit	6.5	pIC50	=	6.5	Binding	In vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tissue homogenate	ChEMBL	729	8	4	13	3.3	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/S0960-894X(01)80583-7
		10897050	106687	0	None	-	0	Rabbit	5.5	pIC50	=	5.5	Binding	Inhibition of the motilin receptor (MTL-R)Inhibition of the motilin receptor (MTL-R)	ChEMBL	565	6	6	6	1.6	CC(C)(C)c1cc(C[C@H]2NC(=O)[C@@H](NC(=O)[C@@H](N)Cc3ccccc3)CCCCNC(=O)CCNC2=O)ccc1O	10.1021/jm010332u
		CHEMBL3143517	106687	0	None	-	0	Rabbit	5.5	pIC50	=	5.5	Binding	Inhibition of the motilin receptor (MTL-R)Inhibition of the motilin receptor (MTL-R)	ChEMBL	565	6	6	6	1.6	CC(C)(C)c1cc(C[C@H]2NC(=O)[C@@H](NC(=O)[C@@H](N)Cc3ccccc3)CCCCNC(=O)CCNC2=O)ccc1O	10.1021/jm010332u
		11146277	106688	0	None	-	0	Rabbit	7.5	pIC50	=	7.5	Binding	Inhibition of the motilin receptor (MTL-R)Inhibition of the motilin receptor (MTL-R)	ChEMBL	579	6	6	6	2.0	CC(C)(C)c1cc(C[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H](N)Cc3ccccc3)CCCCNC(=O)CCCNC2=O)ccc1O	10.1021/jm010332u
		CHEMBL3143518	106688	0	None	-	0	Rabbit	7.5	pIC50	=	7.5	Binding	Inhibition of the motilin receptor (MTL-R)Inhibition of the motilin receptor (MTL-R)	ChEMBL	579	6	6	6	2.0	CC(C)(C)c1cc(C[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H](N)Cc3ccccc3)CCCCNC(=O)CCCNC2=O)ccc1O	10.1021/jm010332u
		CHEMBL2371264	210027	0	None	-	0	Rabbit	7.5	pIC50	=	7.5	Binding	Inhibition of the motilin receptor (MTL-R)Inhibition of the motilin receptor (MTL-R)	ChEMBL		None	None	None		CC(C)(C)c1cc(C[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H](N)Cc3ccccc3)CCCCNC(=O)CNC2=O)ccc1O	10.1021/jm010332u
		44413071	78314	0	None	-	0	Rabbit	7.5	pIC50	=	7.5	Binding	Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor	ChEMBL	731	12	1	7	7.3	O=C(Nc1ccccc1)N(CC1CCCC(N(Cc2cccc([N+](=O)[O-])c2)C(=O)C(Cl)(Cl)Cl)C1)c1cccc(OCCN2CCOCC2)c1	10.1016/j.bmcl.2006.04.017
		CHEMBL210906	78314	0	None	-	0	Rabbit	7.5	pIC50	=	7.5	Binding	Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor	ChEMBL	731	12	1	7	7.3	O=C(Nc1ccccc1)N(CC1CCCC(N(Cc2cccc([N+](=O)[O-])c2)C(=O)C(Cl)(Cl)Cl)C1)c1cccc(OCCN2CCOCC2)c1	10.1016/j.bmcl.2006.04.017
		44380971	57575	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)	ChEMBL	729	8	3	13	3.5	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)OC	10.1016/0960-894X(95)00122-A
		CHEMBL166642	57575	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)	ChEMBL	729	8	3	13	3.5	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)OC	10.1016/0960-894X(95)00122-A
		44583348	187840	0	None	-	1	Rabbit	8.4	pIC50	=	8.4	Binding	Displacement of [125I]motilin from MTL receptor in rabbit duodenum homogenateDisplacement of [125I]motilin from MTL receptor in rabbit duodenum homogenate	ChEMBL	510	10	3	5	2.6	CC(C)[C@@H](C(=O)N(C)[C@@H](Cc1ccc(O)c(C(C)(C)C)c1)C(N)=O)N(C)C(=O)[C@@H](N)Cc1ccccc1	10.1016/j.bmcl.2009.05.059
		CHEMBL496190	187840	0	None	-	1	Rabbit	8.4	pIC50	=	8.4	Binding	Displacement of [125I]motilin from MTL receptor in rabbit duodenum homogenateDisplacement of [125I]motilin from MTL receptor in rabbit duodenum homogenate	ChEMBL	510	10	3	5	2.6	CC(C)[C@@H](C(=O)N(C)[C@@H](Cc1ccc(O)c(C(C)(C)C)c1)C(N)=O)N(C)C(=O)[C@@H](N)Cc1ccccc1	10.1016/j.bmcl.2009.05.059
		44380610	96426	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Compound was tested for in vitro motilin receptor binding affinityCompound was tested for in vitro motilin receptor binding affinity	ChEMBL	743	9	3	13	3.9	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)OC	10.1016/0960-894X(95)00122-A
		CHEMBL262052	96426	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Compound was tested for in vitro motilin receptor binding affinityCompound was tested for in vitro motilin receptor binding affinity	ChEMBL	743	9	3	13	3.9	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)OC	10.1016/0960-894X(95)00122-A
		11081770	89459	0	None	-	0	Rabbit	4.4	pIC50	=	4.4	Binding	Inhibition of the motilin receptor (MTL-R)Inhibition of the motilin receptor (MTL-R)	ChEMBL	509	6	6	6	0.3	N[C@@H](Cc1ccccc1)C(=O)N[C@H]1CCCCNC(=O)CCNC(=O)[C@H](Cc2ccc(O)cc2)NC1=O	10.1021/jm010332u
		CHEMBL2371260	89459	0	None	-	0	Rabbit	4.4	pIC50	=	4.4	Binding	Inhibition of the motilin receptor (MTL-R)Inhibition of the motilin receptor (MTL-R)	ChEMBL	509	6	6	6	0.3	N[C@@H](Cc1ccccc1)C(=O)N[C@H]1CCCCNC(=O)CCNC(=O)[C@H](Cc2ccc(O)cc2)NC1=O	10.1021/jm010332u
		1048	1585	76	None	-	1	Human	7.4	pIC50	=	7.4	Binding	Compound was tested for in vitro motilin receptor binding affinityCompound was tested for in vitro motilin receptor binding affinity	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1016/0960-894X(95)00122-A
		12560	1585	76	None	-	1	Human	7.4	pIC50	=	7.4	Binding	Compound was tested for in vitro motilin receptor binding affinityCompound was tested for in vitro motilin receptor binding affinity	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1016/0960-894X(95)00122-A
		1456	1585	76	None	-	1	Human	7.4	pIC50	=	7.4	Binding	Compound was tested for in vitro motilin receptor binding affinityCompound was tested for in vitro motilin receptor binding affinity	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1016/0960-894X(95)00122-A
		CHEMBL532	1585	76	None	-	1	Human	7.4	pIC50	=	7.4	Binding	Compound was tested for in vitro motilin receptor binding affinityCompound was tested for in vitro motilin receptor binding affinity	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1016/0960-894X(95)00122-A
		DB00199	1585	76	None	-	1	Human	7.4	pIC50	=	7.4	Binding	Compound was tested for in vitro motilin receptor binding affinityCompound was tested for in vitro motilin receptor binding affinity	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1016/0960-894X(95)00122-A
		10897911	156277	0	None	-	0	Rabbit	7.4	pIC50	=	7.4	Binding	Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50	ChEMBL	733	7	5	14	1.8	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/S0960-894X(01)80359-0
		CHEMBL406517	156277	0	None	-	0	Rabbit	7.4	pIC50	=	7.4	Binding	Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50	ChEMBL	733	7	5	14	1.8	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/S0960-894X(01)80359-0
		CHEMBL496389	214081	0	None	-	1	Rabbit	7.3	pIC50	=	7.3	Binding	Displacement of [125I]motilin from MTL receptor in rabbit duodenum homogenateDisplacement of [125I]motilin from MTL receptor in rabbit duodenum homogenate	ChEMBL		None	None	None		CC(C)[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)c(C(C)(C)C)c1)C(N)=O	10.1016/j.bmcl.2009.05.059
		11135894	106692	0	None	-	0	Rabbit	6.3	pIC50	=	6.3	Binding	Inhibition of the motilin receptor (MTL-R)Inhibition of the motilin receptor (MTL-R)	ChEMBL	621	6	6	6	2.9	CC(C)(C)c1cc(C[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H](N)Cc3ccccc3)CCCCNC(=O)CCNC2=O)cc(C(C)(C)C)c1O	10.1021/jm010332u
		CHEMBL3143523	106692	0	None	-	0	Rabbit	6.3	pIC50	=	6.3	Binding	Inhibition of the motilin receptor (MTL-R)Inhibition of the motilin receptor (MTL-R)	ChEMBL	621	6	6	6	2.9	CC(C)(C)c1cc(C[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H](N)Cc3ccccc3)CCCCNC(=O)CCNC2=O)cc(C(C)(C)C)c1O	10.1021/jm010332u
		10995344	106689	0	None	-	0	Rabbit	6.3	pIC50	=	6.3	Binding	Inhibition of the motilin receptor (MTL-R)Inhibition of the motilin receptor (MTL-R)	ChEMBL	565	9	5	6	1.8	CCC(C)Oc1ccc(C[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H](N)Cc3ccccc3)CCCCNC(=O)CCNC2=O)cc1	10.1021/jm010332u
		CHEMBL3143519	106689	0	None	-	0	Rabbit	6.3	pIC50	=	6.3	Binding	Inhibition of the motilin receptor (MTL-R)Inhibition of the motilin receptor (MTL-R)	ChEMBL	565	9	5	6	1.8	CCC(C)Oc1ccc(C[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H](N)Cc3ccccc3)CCCCNC(=O)CCNC2=O)cc1	10.1021/jm010332u
		44412861	77874	0	None	-	0	Rabbit	7.2	pIC50	=	7.2	Binding	Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor	ChEMBL	673	11	0	4	7.9	O=C(c1ccc(F)cc1)N(CC1CCCC(N(Cc2ccccc2)C(=O)C(Cl)(Cl)Cl)C1)c1cccc(OCCN2CCCC2)c1	10.1016/j.bmcl.2006.04.017
		CHEMBL209333	77874	0	None	-	0	Rabbit	7.2	pIC50	=	7.2	Binding	Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor	ChEMBL	673	11	0	4	7.9	O=C(c1ccc(F)cc1)N(CC1CCCC(N(Cc2ccccc2)C(=O)C(Cl)(Cl)Cl)C1)c1cccc(OCCN2CCCC2)c1	10.1016/j.bmcl.2006.04.017
		44412878	141082	0	None	-	0	Rabbit	7.2	pIC50	=	7.2	Binding	Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor	ChEMBL	707	11	0	4	8.6	O=C(c1ccc(F)cc1)N(CC1CCCC(N(Cc2cccc(Cl)c2)C(=O)C(Cl)(Cl)Cl)C1)c1cccc(OCCN2CCCC2)c1	10.1016/j.bmcl.2006.04.017
		CHEMBL382612	141082	0	None	-	0	Rabbit	7.2	pIC50	=	7.2	Binding	Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor	ChEMBL	707	11	0	4	8.6	O=C(c1ccc(F)cc1)N(CC1CCCC(N(Cc2cccc(Cl)c2)C(=O)C(Cl)(Cl)Cl)C1)c1cccc(OCCN2CCCC2)c1	10.1016/j.bmcl.2006.04.017
		11146277	106688	0	None	-	0	Rabbit	7.2	pIC50	=	7.2	Binding	Inhibition of the motilin receptor (MTL-R)Inhibition of the motilin receptor (MTL-R)	ChEMBL	579	6	6	6	2.0	CC(C)(C)c1cc(C[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H](N)Cc3ccccc3)CCCCNC(=O)CCCNC2=O)ccc1O	10.1021/jm010332u
		CHEMBL3143518	106688	0	None	-	0	Rabbit	7.2	pIC50	=	7.2	Binding	Inhibition of the motilin receptor (MTL-R)Inhibition of the motilin receptor (MTL-R)	ChEMBL	579	6	6	6	2.0	CC(C)(C)c1cc(C[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H](N)Cc3ccccc3)CCCCNC(=O)CCCNC2=O)ccc1O	10.1021/jm010332u
		CHEMBL502792	214158	0	None	-	1	Rabbit	8.2	pIC50	=	8.2	Binding	Displacement of [125I]motilin from MTL receptor in rabbit duodenum homogenateDisplacement of [125I]motilin from MTL receptor in rabbit duodenum homogenate	ChEMBL		None	None	None		CC(C)(C)c1cc(C[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)Cc2ccccc2)C(N)=O)ccc1O	10.1016/j.bmcl.2009.05.059
		44276778	98206	0	None	-	0	Rabbit	8.2	pIC50	=	8.2	Binding	Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50	ChEMBL	755	9	2	13	4.5	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC	10.1016/S0960-894X(01)80359-0
		CHEMBL27424	98206	0	None	-	0	Rabbit	8.2	pIC50	=	8.2	Binding	Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50	ChEMBL	755	9	2	13	4.5	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC	10.1016/S0960-894X(01)80359-0
		44276778	98206	0	None	-	0	Rabbit	8.2	pIC50	=	8.2	Binding	In vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenate	ChEMBL	755	9	2	13	4.5	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC	10.1016/S0960-894X(01)80583-7
		CHEMBL27424	98206	0	None	-	0	Rabbit	8.2	pIC50	=	8.2	Binding	In vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenate	ChEMBL	755	9	2	13	4.5	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC	10.1016/S0960-894X(01)80583-7
		44276779	96871	0	None	-	0	Rabbit	8.2	pIC50	=	8.2	Binding	Concentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor bindingConcentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor binding	ChEMBL	741	9	2	13	4.1	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC	10.1016/S0960-894X(01)80359-0
		CHEMBL265495	96871	0	None	-	0	Rabbit	8.2	pIC50	=	8.2	Binding	Concentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor bindingConcentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor binding	ChEMBL	741	9	2	13	4.1	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC	10.1016/S0960-894X(01)80359-0
		44276779	96871	0	None	-	0	Rabbit	8.2	pIC50	=	8.2	Binding	In vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tissue homogenate	ChEMBL	741	9	2	13	4.1	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC	10.1016/S0960-894X(01)80583-7
		CHEMBL265495	96871	0	None	-	0	Rabbit	8.2	pIC50	=	8.2	Binding	In vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tissue homogenate	ChEMBL	741	9	2	13	4.1	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC	10.1016/S0960-894X(01)80583-7
		44380651	120132	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Compound was tested for in vitro motilin receptor binding affinityCompound was tested for in vitro motilin receptor binding affinity	ChEMBL	757	9	3	13	4.3	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)OC	10.1016/0960-894X(95)00122-A
		CHEMBL351216	120132	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Compound was tested for in vitro motilin receptor binding affinityCompound was tested for in vitro motilin receptor binding affinity	ChEMBL	757	9	3	13	4.3	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)OC	10.1016/0960-894X(95)00122-A
		23557214	141083	0	None	-	0	Rabbit	7.2	pIC50	=	7.2	Binding	Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor	ChEMBL	721	11	0	4	8.9	O=C(c1ccc(F)cc1)N(CC1CCCC(N(Cc2cccc(Cl)c2)C(=O)C(Cl)(Cl)Cl)C1)c1cccc(OCCN2CCCCC2)c1	10.1016/j.bmcl.2006.04.017
		CHEMBL382613	141083	0	None	-	0	Rabbit	7.2	pIC50	=	7.2	Binding	Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor	ChEMBL	721	11	0	4	8.9	O=C(c1ccc(F)cc1)N(CC1CCCC(N(Cc2cccc(Cl)c2)C(=O)C(Cl)(Cl)Cl)C1)c1cccc(OCCN2CCCCC2)c1	10.1016/j.bmcl.2006.04.017
		11767227	106691	0	None	-	0	Rabbit	7.2	pIC50	=	7.2	Binding	Inhibition of the motilin receptor (MTL-R)Inhibition of the motilin receptor (MTL-R)	ChEMBL	607	6	6	6	2.7	CC(C)(C)c1cc(C[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H](N)Cc3ccccc3)CCCCNC(=O)CCCCCNC2=O)ccc1O	10.1021/jm010332u
		CHEMBL3143521	106691	0	None	-	0	Rabbit	7.2	pIC50	=	7.2	Binding	Inhibition of the motilin receptor (MTL-R)Inhibition of the motilin receptor (MTL-R)	ChEMBL	607	6	6	6	2.7	CC(C)(C)c1cc(C[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H](N)Cc3ccccc3)CCCCNC(=O)CCCCCNC2=O)ccc1O	10.1021/jm010332u
		44412941	140330	0	None	-	0	Rabbit	6.2	pIC50	=	6.2	Binding	Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor	ChEMBL	710	13	1	6	8.0	COc1cccc(C(=O)N(Cc2cccc(Cl)c2)C2CCCC(CN(C(=O)Nc3ccccc3)c3cccc(OCCN4CCOCC4)c3)C2)c1	10.1016/j.bmcl.2006.04.017
		CHEMBL380678	140330	0	None	-	0	Rabbit	6.2	pIC50	=	6.2	Binding	Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor	ChEMBL	710	13	1	6	8.0	COc1cccc(C(=O)N(Cc2cccc(Cl)c2)C2CCCC(CN(C(=O)Nc3ccccc3)c3cccc(OCCN4CCOCC4)c3)C2)c1	10.1016/j.bmcl.2006.04.017
		44413072	78316	0	None	-	0	Rabbit	6.2	pIC50	=	6.2	Binding	Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor	ChEMBL	636	12	1	6	6.9	O=C(Nc1ccccc1)N(CC1CCCC(N(Cc2ccccc2)C(=O)c2ccco2)C1)c1cccc(OCCN2CCOCC2)c1	10.1016/j.bmcl.2006.04.017
		CHEMBL210923	78316	0	None	-	0	Rabbit	6.2	pIC50	=	6.2	Binding	Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor	ChEMBL	636	12	1	6	6.9	O=C(Nc1ccccc1)N(CC1CCCC(N(Cc2ccccc2)C(=O)c2ccco2)C1)c1cccc(OCCN2CCOCC2)c1	10.1016/j.bmcl.2006.04.017
		CHEMBL2371264	210027	0	None	-	0	Rabbit	8.2	pIC50	=	8.2	Binding	Inhibition of the motilin receptor (MTL-R)Inhibition of the motilin receptor (MTL-R)	ChEMBL		None	None	None		CC(C)(C)c1cc(C[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H](N)Cc3ccccc3)CCCCNC(=O)CNC2=O)ccc1O	10.1021/jm010332u
		44380971	57575	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Compound was tested for in vitro motilin receptor binding affinityCompound was tested for in vitro motilin receptor binding affinity	ChEMBL	729	8	3	13	3.5	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)OC	10.1016/0960-894X(95)00122-A
		CHEMBL166642	57575	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Compound was tested for in vitro motilin receptor binding affinityCompound was tested for in vitro motilin receptor binding affinity	ChEMBL	729	8	3	13	3.5	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)OC	10.1016/0960-894X(95)00122-A
		44276778	98206	0	None	-	0	Rabbit	8.1	pIC50	=	8.1	Binding	Concentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor bindingConcentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor binding	ChEMBL	755	9	2	13	4.5	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC	10.1016/S0960-894X(01)80359-0
		CHEMBL27424	98206	0	None	-	0	Rabbit	8.1	pIC50	=	8.1	Binding	Concentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor bindingConcentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor binding	ChEMBL	755	9	2	13	4.5	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC	10.1016/S0960-894X(01)80359-0
		44276778	98206	0	None	-	0	Rabbit	8.1	pIC50	=	8.1	Binding	In vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tissue homogenate	ChEMBL	755	9	2	13	4.5	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC	10.1016/S0960-894X(01)80583-7
		CHEMBL27424	98206	0	None	-	0	Rabbit	8.1	pIC50	=	8.1	Binding	In vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tissue homogenate	ChEMBL	755	9	2	13	4.5	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC	10.1016/S0960-894X(01)80583-7
		1048	1585	76	None	-	1	Human	7.2	pIC50	=	7.2	Binding	Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1016/0960-894X(95)00122-A
		12560	1585	76	None	-	1	Human	7.2	pIC50	=	7.2	Binding	Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1016/0960-894X(95)00122-A
		1456	1585	76	None	-	1	Human	7.2	pIC50	=	7.2	Binding	Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1016/0960-894X(95)00122-A
		CHEMBL532	1585	76	None	-	1	Human	7.2	pIC50	=	7.2	Binding	Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1016/0960-894X(95)00122-A
		DB00199	1585	76	None	-	1	Human	7.2	pIC50	=	7.2	Binding	Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1016/0960-894X(95)00122-A
		10897911	156277	0	None	-	0	Rabbit	7.2	pIC50	=	7.2	Binding	Concentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor bindingConcentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor binding	ChEMBL	733	7	5	14	1.8	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/S0960-894X(01)80359-0
		CHEMBL406517	156277	0	None	-	0	Rabbit	7.2	pIC50	=	7.2	Binding	Concentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor bindingConcentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor binding	ChEMBL	733	7	5	14	1.8	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O	10.1016/S0960-894X(01)80359-0
		12016400	168960	0	None	-	0	Rabbit	7.1	pIC50	=	7.1	Binding	Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor	ChEMBL	613	11	0	4	7.6	CC(C)(C)C(=O)N(Cc1ccccc1)[C@H]1CCC[C@@H](CN(C(=O)c2ccc(F)cc2)c2cccc(OCCN3CCCC3)c2)C1	10.1016/j.bmcl.2006.04.017
		CHEMBL438962	168960	0	None	-	0	Rabbit	7.1	pIC50	=	7.1	Binding	Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor	ChEMBL	613	11	0	4	7.6	CC(C)(C)C(=O)N(Cc1ccccc1)[C@H]1CCC[C@@H](CN(C(=O)c2ccc(F)cc2)c2cccc(OCCN3CCCC3)c2)C1	10.1016/j.bmcl.2006.04.017
		44412951	78170	0	None	-	0	Rabbit	6.1	pIC50	=	6.1	Binding	Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor	ChEMBL	674	14	1	5	7.7	O=C(Nc1ccccc1)N(CC1CCCC(N(Cc2ccccc2)C(=O)CCc2ccccc2)C1)c1cccc(OCCN2CCOCC2)c1	10.1016/j.bmcl.2006.04.017
		CHEMBL210447	78170	0	None	-	0	Rabbit	6.1	pIC50	=	6.1	Binding	Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor	ChEMBL	674	14	1	5	7.7	O=C(Nc1ccccc1)N(CC1CCCC(N(Cc2ccccc2)C(=O)CCc2ccccc2)C1)c1cccc(OCCN2CCOCC2)c1	10.1016/j.bmcl.2006.04.017
		10875453	106690	0	None	-	0	Rabbit	5.1	pIC50	=	5.1	Binding	Inhibition of the motilin receptor (MTL-R)Inhibition of the motilin receptor (MTL-R)	ChEMBL	565	7	5	6	1.8	CC(C)(C)Oc1ccc(C[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H](N)Cc3ccccc3)CCCCNC(=O)CCNC2=O)cc1	10.1021/jm010332u
		CHEMBL3143520	106690	0	None	-	0	Rabbit	5.1	pIC50	=	5.1	Binding	Inhibition of the motilin receptor (MTL-R)Inhibition of the motilin receptor (MTL-R)	ChEMBL	565	7	5	6	1.8	CC(C)(C)Oc1ccc(C[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H](N)Cc3ccccc3)CCCCNC(=O)CCNC2=O)cc1	10.1021/jm010332u
		44412982	59060	0	None	-	0	Rabbit	6.1	pIC50	=	6.1	Binding	Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor	ChEMBL	644	11	1	5	7.2	CC(C)(C)C(=O)N(Cc1ccccc1)C1CCCC(CN(C(=O)Nc2ccc(F)cc2)c2cccc(OCCN3CCOCC3)c2)C1	10.1016/j.bmcl.2006.04.017
		CHEMBL169509	59060	0	None	-	0	Rabbit	6.1	pIC50	=	6.1	Binding	Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor	ChEMBL	644	11	1	5	7.2	CC(C)(C)C(=O)N(Cc1ccccc1)C1CCCC(CN(C(=O)Nc2ccc(F)cc2)c2cccc(OCCN3CCOCC3)c2)C1	10.1016/j.bmcl.2006.04.017
		44380610	96426	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)	ChEMBL	743	9	3	13	3.9	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)OC	10.1016/0960-894X(95)00122-A
		CHEMBL262052	96426	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)	ChEMBL	743	9	3	13	3.9	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)CC)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)OC	10.1016/0960-894X(95)00122-A
		44276817	98202	0	None	-	0	Rabbit	8.1	pIC50	=	8.1	Binding	Concentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor bindingConcentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor binding	ChEMBL	727	8	2	13	3.8	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC	10.1016/S0960-894X(01)80359-0
		CHEMBL27419	98202	0	None	-	0	Rabbit	8.1	pIC50	=	8.1	Binding	Concentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor bindingConcentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor binding	ChEMBL	727	8	2	13	3.8	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC	10.1016/S0960-894X(01)80359-0
		44276817	98202	0	None	-	0	Rabbit	8.1	pIC50	=	8.1	Binding	In vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tissue homogenate	ChEMBL	727	8	2	13	3.8	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC	10.1016/S0960-894X(01)80583-7
		CHEMBL27419	98202	0	None	-	0	Rabbit	8.1	pIC50	=	8.1	Binding	In vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tissue homogenate	ChEMBL	727	8	2	13	3.8	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC	10.1016/S0960-894X(01)80583-7
		44276817	98202	0	None	-	0	Rabbit	8.0	pIC50	=	8.0	Binding	Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50	ChEMBL	727	8	2	13	3.8	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC	10.1016/S0960-894X(01)80359-0
		CHEMBL27419	98202	0	None	-	0	Rabbit	8.0	pIC50	=	8.0	Binding	Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50	ChEMBL	727	8	2	13	3.8	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC	10.1016/S0960-894X(01)80359-0
		44276817	98202	0	None	-	0	Rabbit	8.0	pIC50	=	8.0	Binding	In vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenate	ChEMBL	727	8	2	13	3.8	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC	10.1016/S0960-894X(01)80583-7
		CHEMBL27419	98202	0	None	-	0	Rabbit	8.0	pIC50	=	8.0	Binding	In vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenateIn vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenate	ChEMBL	727	8	2	13	3.8	CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC(N(C)C)[C@H]2O)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC	10.1016/S0960-894X(01)80583-7
		44412977	79814	0	None	-	0	Rabbit	6.0	pIC50	=	6.0	Binding	Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor	ChEMBL	686	11	1	5	7.4	O=C(Nc1ccccc1)N(CC1CCCC(N(Cc2ccccc2)C(=O)C(Cl)(Cl)Cl)C1)c1cccc(OCCN2CCOCC2)c1	10.1016/j.bmcl.2006.04.017
		CHEMBL212044	79814	0	None	-	0	Rabbit	6.0	pIC50	=	6.0	Binding	Inhibition of [125]I-motilin binding to rabbit motilin receptorInhibition of [125]I-motilin binding to rabbit motilin receptor	ChEMBL	686	11	1	5	7.4	O=C(Nc1ccccc1)N(CC1CCCC(N(Cc2ccccc2)C(=O)C(Cl)(Cl)Cl)C1)c1cccc(OCCN2CCOCC2)c1	10.1016/j.bmcl.2006.04.017
		CHEMBL2372767	210285	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL		None	None	None		CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccccc1)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)O)[C@@H](C)O	10.1021/jm0606600
		10010118	101435	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	In vitro binding affinity towards human motilin receptorIn vitro binding affinity towards human motilin receptor	ChEMBL	723	13	4	11	1.7	NC(=O)[C@H](CCc1ccccc1)NC(=O)[C@H](CCc1ccccc1)NC(=O)C1CCC2(CCNCC2)n2c(=O)n(Cc3ccc4c(c3)OCO4)c(=O)n21	10.1021/jm0304865
		CHEMBL297494	101435	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	In vitro binding affinity towards human motilin receptorIn vitro binding affinity towards human motilin receptor	ChEMBL	723	13	4	11	1.7	NC(=O)[C@H](CCc1ccccc1)NC(=O)[C@H](CCc1ccccc1)NC(=O)C1CCC2(CCNCC2)n2c(=O)n(Cc3ccc4c(c3)OCO4)c(=O)n21	10.1021/jm0304865
		10010118	101435	0	None	-	1	Human	9.0	pKi	=	9	Binding	In vitro binding affinity towards human motilin receptorIn vitro binding affinity towards human motilin receptor	ChEMBL	723	13	4	11	1.7	NC(=O)[C@H](CCc1ccccc1)NC(=O)[C@H](CCc1ccccc1)NC(=O)C1CCC2(CCNCC2)n2c(=O)n(Cc3ccc4c(c3)OCO4)c(=O)n21	10.1021/jm0304865
		CHEMBL297494	101435	0	None	-	1	Human	9.0	pKi	=	9	Binding	In vitro binding affinity towards human motilin receptorIn vitro binding affinity towards human motilin receptor	ChEMBL	723	13	4	11	1.7	NC(=O)[C@H](CCc1ccccc1)NC(=O)[C@H](CCc1ccccc1)NC(=O)C1CCC2(CCNCC2)n2c(=O)n(Cc3ccc4c(c3)OCO4)c(=O)n21	10.1021/jm0304865
		25115428	160763	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	610	5	6	7	1.0	CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(Cl)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CN/C(N)=N/C#N)NC1=O	10.1016/j.bmcl.2007.05.043
		CHEMBL411408	160763	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	610	5	6	7	1.0	CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(Cl)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CN/C(N)=N/C#N)NC1=O	10.1016/j.bmcl.2007.05.043
		11444593	172726	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	578	5	4	6	4.0	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2csc3ccccc23)NCCOc2ccccc2CCCNC1=O	10.1021/jm0606600
		CHEMBL450634	172726	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	578	5	4	6	4.0	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2csc3ccccc23)NCCOc2ccccc2CCCNC1=O	10.1021/jm0606600
		44432981	87973	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	595	5	4	7	2.8	CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(F)c2)NCCOc2ccccc2CCCNC(=O)[C@H](Cc2cscn2)NC1=O	10.1016/j.bmcl.2007.05.043
		CHEMBL234191	87973	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	595	5	4	7	2.8	CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(F)c2)NCCOc2ccccc2CCCNC(=O)[C@H](Cc2cscn2)NC1=O	10.1016/j.bmcl.2007.05.043
		11995356	80553	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	488	5	5	5	2.8	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCCCCCCCNC1=O	10.1021/jm0606600
		CHEMBL214869	80553	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	488	5	5	5	2.8	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCCCCCCCNC1=O	10.1021/jm0606600
		11994554	80572	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	536	5	5	6	2.5	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC1=O	10.1021/jm0606600
		CHEMBL214935	80572	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	536	5	5	6	2.5	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC1=O	10.1021/jm0606600
		11994554	80572	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	536	5	5	6	2.5	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC1=O	10.1016/j.bmcl.2007.05.043
		CHEMBL214935	80572	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	536	5	5	6	2.5	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC1=O	10.1016/j.bmcl.2007.05.043
		11994677	141899	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	508	3	5	6	1.8	CC(C)[C@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC(=O)[C@H](C)NC1=O	10.1021/jm0606600
		CHEMBL386854	141899	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	508	3	5	6	1.8	CC(C)[C@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC(=O)[C@H](C)NC1=O	10.1021/jm0606600
		11995358	80600	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	536	6	4	5	3.1	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](CCc2ccccc2)NCCOc2ccccc2CCCNC1=O	10.1021/jm0606600
		CHEMBL215043	80600	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	536	6	4	5	3.1	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](CCc2ccccc2)NCCOc2ccccc2CCCNC1=O	10.1021/jm0606600
		44432973	98312	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	577	4	5	6	1.9	CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(C(F)(F)F)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CN)NC1=O	10.1016/j.bmcl.2007.05.043
		CHEMBL274876	98312	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	577	4	5	6	1.9	CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(C(F)(F)F)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CN)NC1=O	10.1016/j.bmcl.2007.05.043
		11995155	141908	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	584	6	5	6	3.1	CCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC1=O	10.1021/jm0606600
		CHEMBL386906	141908	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	584	6	5	6	3.1	CCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC1=O	10.1021/jm0606600
		11410548	87565	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	571	5	4	6	2.2	CC(C)[C@H]1NC(=O)[C@@H](Cc2ccc(Cl)cc2)NCCOc2ccccc2CCCNC(=O)[C@H](CN(C)C)NC1=O	10.1016/j.bmcl.2007.05.043
		CHEMBL233561	87565	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	571	5	4	6	2.2	CC(C)[C@H]1NC(=O)[C@@H](Cc2ccc(Cl)cc2)NCCOc2ccccc2CCCNC(=O)[C@H](CN(C)C)NC1=O	10.1016/j.bmcl.2007.05.043
		25115652	97286	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	643	5	4	8	2.6	Cc1cnnn1C[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2cccc(C(F)(F)F)c2)NCCOc2ccccc2CCCNC1=O	10.1016/j.bmcl.2007.05.043
		CHEMBL269007	97286	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	643	5	4	8	2.6	Cc1cnnn1C[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2cccc(C(F)(F)F)c2)NCCOc2ccccc2CCCNC1=O	10.1016/j.bmcl.2007.05.043
		44432969	147603	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	525	4	6	7	0.6	CC(C)[C@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2CCCNC(=O)[C@H](CN)NC1=O	10.1016/j.bmcl.2007.05.043
		CHEMBL393112	147603	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	525	4	6	7	0.6	CC(C)[C@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2CCCNC(=O)[C@H](CN)NC1=O	10.1016/j.bmcl.2007.05.043
		25114977	147009	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	594	5	4	7	2.5	CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(Cl)c2)NCCOc2ccccc2CCCNC(=O)[C@H](Cn2cccn2)NC1=O	10.1016/j.bmcl.2007.05.043
		CHEMBL392657	147009	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	594	5	4	7	2.5	CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(Cl)c2)NCCOc2ccccc2CCCNC(=O)[C@H](Cn2cccn2)NC1=O	10.1016/j.bmcl.2007.05.043
		11994680	168765	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	584	5	5	6	3.0	CC(C)[C@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm0606600
		CHEMBL437326	168765	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	584	5	5	6	3.0	CC(C)[C@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm0606600
		11995359	168966	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	539	5	4	7	2.9	CCC[C@@H]1OC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2CCCNC1=O	10.1021/jm0606600
		CHEMBL438998	168966	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	539	5	4	7	2.9	CCC[C@@H]1OC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2CCCNC1=O	10.1021/jm0606600
		44467360	124535	0	None	-3	2	Human	4.7	pKi	=	4.7	Binding	Inhibition of human motilin receptorInhibition of human motilin receptor	ChEMBL	420	3	2	6	1.5	COc1nc(N2C[C@H]3C(=O)N(C)C(=N)N[C@@]3(c3ccc(F)cc3F)C2)nc(C)c1F	10.1021/acs.jmedchem.5b01995
		CHEMBL3640290	124535	0	None	-3	2	Human	4.7	pKi	=	4.7	Binding	Inhibition of human motilin receptorInhibition of human motilin receptor	ChEMBL	420	3	2	6	1.5	COc1nc(N2C[C@H]3C(=O)N(C)C(=N)N[C@@]3(c3ccc(F)cc3F)C2)nc(C)c1F	10.1021/acs.jmedchem.5b01995
		11994928	141869	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	539	5	4	7	2.9	CCC[C@@H]1NC(=O)[C@@H](C(C)C)OC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2CCCNC1=O	10.1021/jm0606600
		CHEMBL386626	141869	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	539	5	4	7	2.9	CCC[C@@H]1NC(=O)[C@@H](C(C)C)OC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2CCCNC1=O	10.1021/jm0606600
		44432971	87038	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	567	5	6	7	0.8	CC(=O)NC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2CCCNC1=O	10.1016/j.bmcl.2007.05.043
		CHEMBL232551	87038	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	567	5	6	7	0.8	CC(=O)NC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2CCCNC1=O	10.1016/j.bmcl.2007.05.043
		11995153	141635	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	508	4	5	6	1.9	CCC[C@@H]1NC(=O)[C@@H](C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC1=O	10.1021/jm0606600
		CHEMBL385293	141635	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	508	4	5	6	1.9	CCC[C@@H]1NC(=O)[C@@H](C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC1=O	10.1021/jm0606600
		11181688	101335	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	In vitro binding affinity towards human motilin receptorIn vitro binding affinity towards human motilin receptor	ChEMBL	721	13	4	11	1.5	NC(=O)[C@H](CCc1ccccc1)NC(=O)[C@H](CCc1ccccc1)NC(=O)C1C=CC2(CCNCC2)n2c(=O)n(Cc3ccc4c(c3)OCO4)c(=O)n21	10.1021/jm0304865
		CHEMBL296748	101335	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	In vitro binding affinity towards human motilin receptorIn vitro binding affinity towards human motilin receptor	ChEMBL	721	13	4	11	1.5	NC(=O)[C@H](CCc1ccccc1)NC(=O)[C@H](CCc1ccccc1)NC(=O)C1C=CC2(CCNCC2)n2c(=O)n(Cc3ccc4c(c3)OCO4)c(=O)n21	10.1021/jm0304865
		71720372	89053	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Agonist activity at MLNR (unknown origin)Agonist activity at MLNR (unknown origin)	ChEMBL	570	13	4	6	3.3	CCNC(=O)[C@H](Cc1ccc(O)c(C(C)(C)C)c1)C(N)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](Cc1ccc(F)cc1)NC	10.1021/jm301653f
		CHEMBL2313632	89053	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Agonist activity at MLNR (unknown origin)Agonist activity at MLNR (unknown origin)	ChEMBL	570	13	4	6	3.3	CCNC(=O)[C@H](Cc1ccc(O)c(C(C)(C)C)c1)C(N)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](Cc1ccc(F)cc1)NC	10.1021/jm301653f
		CHEMBL2364821	89053	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Agonist activity at MLNR (unknown origin)Agonist activity at MLNR (unknown origin)	ChEMBL	570	13	4	6	3.3	CCNC(=O)[C@H](Cc1ccc(O)c(C(C)(C)C)c1)C(N)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](Cc1ccc(F)cc1)NC	10.1021/jm301653f
		44292517	101531	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	In vitro binding affinity towards human motilin receptorIn vitro binding affinity towards human motilin receptor	ChEMBL	723	13	4	11	1.7	NC(=O)[C@@H](CCc1ccccc1)NC(=O)[C@@H](CCc1ccccc1)NC(=O)C1CCC2(CCNCC2)n2c(=O)n(Cc3ccc4c(c3)OCO4)c(=O)n21	10.1021/jm0304865
		CHEMBL298224	101531	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	In vitro binding affinity towards human motilin receptorIn vitro binding affinity towards human motilin receptor	ChEMBL	723	13	4	11	1.7	NC(=O)[C@@H](CCc1ccccc1)NC(=O)[C@@H](CCc1ccccc1)NC(=O)C1CCC2(CCNCC2)n2c(=O)n(Cc3ccc4c(c3)OCO4)c(=O)n21	10.1021/jm0304865
		25115429	86700	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	655	6	5	8	2.9	CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(C(F)(F)F)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CNc2ncccn2)NC1=O	10.1016/j.bmcl.2007.05.043
		CHEMBL231744	86700	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	655	6	5	8	2.9	CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(C(F)(F)F)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CNc2ncccn2)NC1=O	10.1016/j.bmcl.2007.05.043
		25115653	147007	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	644	5	4	9	2.0	Cc1nnnn1C[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2cccc(C(F)(F)F)c2)NCCOc2ccccc2CCCNC1=O	10.1016/j.bmcl.2007.05.043
		CHEMBL392656	147007	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	644	5	4	9	2.0	Cc1nnnn1C[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2cccc(C(F)(F)F)c2)NCCOc2ccccc2CCCNC1=O	10.1016/j.bmcl.2007.05.043
		11250008	80413	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	566	5	4	6	3.0	CC(C)C[C@H]1C(=O)NCCCc2ccccc2OCCN[C@H](Cc2ccc(O)cc2)C(=O)N[C@H](C(C)C)C(=O)N1C	10.1021/jm0606600
		CHEMBL214570	80413	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	566	5	4	6	3.0	CC(C)C[C@H]1C(=O)NCCCc2ccccc2OCCN[C@H](Cc2ccc(O)cc2)C(=O)N[C@H](C(C)C)C(=O)N1C	10.1021/jm0606600
		25115654	160004	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	657	5	4	8	2.9	Cc1nnn(C[C@@H]2NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc3cccc(C(F)(F)F)c3)NCCOc3ccccc3CCCNC2=O)c1C	10.1016/j.bmcl.2007.05.043
		CHEMBL410786	160004	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	657	5	4	8	2.9	Cc1nnn(C[C@@H]2NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc3cccc(C(F)(F)F)c3)NCCOc3ccccc3CCCNC2=O)c1C	10.1016/j.bmcl.2007.05.043
		11995042	141887	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	553	5	6	7	2.0	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NNC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2CCCNC1=O	10.1021/jm0606600
		CHEMBL386735	141887	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	553	5	6	7	2.0	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NNC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2CCCNC1=O	10.1021/jm0606600
		11192254	141709	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	561	5	5	5	3.2	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NCCOc2ccccc2CCCNC1=O	10.1021/jm0606600
		CHEMBL385673	141709	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	561	5	5	5	3.2	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NCCOc2ccccc2CCCNC1=O	10.1021/jm0606600
		11995157	169324	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	552	5	6	7	1.2	CC(C)[C@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC(=O)[C@H](CC(=O)O)NC1=O	10.1021/jm0606600
		CHEMBL441697	169324	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	552	5	6	7	1.2	CC(C)[C@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC(=O)[C@H](CC(=O)O)NC1=O	10.1021/jm0606600
		11995157	169324	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	552	5	6	7	1.2	CC(C)[C@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC(=O)[C@H](CC(=O)O)NC1=O	10.1016/j.bmcl.2007.05.043
		CHEMBL441697	169324	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	552	5	6	7	1.2	CC(C)[C@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC(=O)[C@H](CC(=O)O)NC1=O	10.1016/j.bmcl.2007.05.043
		25115200	88245	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	584	6	6	6	2.3	CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(Cl)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CCC(=N)N)NC1=O	10.1016/j.bmcl.2007.05.043
		CHEMBL234810	88245	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	584	6	6	6	2.3	CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(Cl)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CCC(=N)N)NC1=O	10.1016/j.bmcl.2007.05.043
		44432976	154864	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	571	5	4	6	2.2	CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(Cl)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CN(C)C)NC1=O	10.1016/j.bmcl.2007.05.043
		CHEMBL400635	154864	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	571	5	4	6	2.2	CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(Cl)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CN(C)C)NC1=O	10.1016/j.bmcl.2007.05.043
		11995454	141774	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	552	5	4	6	2.8	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)N(C)CCOc2ccccc2CCCNC1=O	10.1021/jm0606600
		CHEMBL386086	141774	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	552	5	4	6	2.8	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)N(C)CCOc2ccccc2CCCNC1=O	10.1021/jm0606600
		CHEMBL2372767	210285	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	In vitro binding affinity towards human motilin receptorIn vitro binding affinity towards human motilin receptor	ChEMBL		None	None	None		CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccccc1)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)O)[C@@H](C)O	10.1021/jm0304865
		53322109	56269	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	In vitro binding affinity towards human motilin receptorIn vitro binding affinity towards human motilin receptor	ChEMBL	697	8	2	11	5.2	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@H]1C	10.1021/jm0304865
		CHEMBL1628277	56269	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	In vitro binding affinity towards human motilin receptorIn vitro binding affinity towards human motilin receptor	ChEMBL	697	8	2	11	5.2	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)C[C@@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC)[C@H]2O)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@H]1C	10.1021/jm0304865
		44432974	87564	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	557	5	5	6	1.8	CNC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NCCOc2ccccc2CCCNC1=O	10.1016/j.bmcl.2007.05.043
		CHEMBL233560	87564	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	557	5	5	6	1.8	CNC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NCCOc2ccccc2CCCNC1=O	10.1016/j.bmcl.2007.05.043
		11995041	80482	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	524	5	5	6	2.9	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2CCCNC1=O	10.1021/jm0606600
		CHEMBL214685	80482	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	524	5	5	6	2.9	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2CCCNC1=O	10.1021/jm0606600
		11995357	141451	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	528	5	4	5	3.5	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](CC2CCCCC2)NCCOc2ccccc2CCCNC1=O	10.1021/jm0606600
		CHEMBL384204	141451	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	528	5	4	5	3.5	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](CC2CCCCC2)NCCOc2ccccc2CCCNC1=O	10.1021/jm0606600
		25114744	160765	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	599	6	7	6	1.5	CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(Cl)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CCNC(=N)N)NC1=O	10.1016/j.bmcl.2007.05.043
		CHEMBL411409	160765	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	599	6	7	6	1.5	CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(Cl)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CCNC(=N)N)NC1=O	10.1016/j.bmcl.2007.05.043
		11994678	141388	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	536	5	5	6	2.5	CCC[C@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC1=O	10.1021/jm0606600
		CHEMBL383881	141388	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	536	5	5	6	2.5	CCC[C@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC1=O	10.1021/jm0606600
		44432968	86949	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	539	5	6	7	1.0	CC(C)[C@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2CCCNC(=O)[C@H](CCN)NC1=O	10.1016/j.bmcl.2007.05.043
		CHEMBL232342	86949	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	539	5	6	7	1.0	CC(C)[C@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2CCCNC(=O)[C@H](CCN)NC1=O	10.1016/j.bmcl.2007.05.043
		11994556	80489	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	472	4	4	5	2.2	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](C(C)C)NCCOc2ccccc2/C=C/CNC1=O	10.1021/jm0606600
		CHEMBL214703	80489	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	472	4	4	5	2.2	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](C(C)C)NCCOc2ccccc2/C=C/CNC1=O	10.1021/jm0606600
		1048	1585	76	None	-	1	Human	4.4	pKi	=	4.4	Binding	In vitro binding affinity towards human motilin receptorIn vitro binding affinity towards human motilin receptor	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1021/jm0304865
		12560	1585	76	None	-	1	Human	4.4	pKi	=	4.4	Binding	In vitro binding affinity towards human motilin receptorIn vitro binding affinity towards human motilin receptor	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1021/jm0304865
		1456	1585	76	None	-	1	Human	4.4	pKi	=	4.4	Binding	In vitro binding affinity towards human motilin receptorIn vitro binding affinity towards human motilin receptor	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1021/jm0304865
		CHEMBL532	1585	76	None	-	1	Human	4.4	pKi	=	4.4	Binding	In vitro binding affinity towards human motilin receptorIn vitro binding affinity towards human motilin receptor	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1021/jm0304865
		DB00199	1585	76	None	-	1	Human	4.4	pKi	=	4.4	Binding	In vitro binding affinity towards human motilin receptorIn vitro binding affinity towards human motilin receptor	ChEMBL	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	10.1021/jm0304865
		44432970	87037	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	567	6	6	7	1.7	CC(C)NC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2CCCNC1=O	10.1016/j.bmcl.2007.05.043
		CHEMBL232550	87037	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	567	6	6	7	1.7	CC(C)NC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2CCCNC1=O	10.1016/j.bmcl.2007.05.043
		23656869	147856	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	631	5	4	6	3.1	CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(C(F)(F)F)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CN2CCCC2)NC1=O	10.1016/j.bmcl.2007.05.043
		CHEMBL393315	147856	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	631	5	4	6	3.1	CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(C(F)(F)F)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CN2CCCC2)NC1=O	10.1016/j.bmcl.2007.05.043
		44432979	148517	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	626	6	5	8	3.2	CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(Cl)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CNc2nccs2)NC1=O	10.1016/j.bmcl.2007.05.043
		CHEMBL393842	148517	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	626	6	5	8	3.2	CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(Cl)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CNc2nccs2)NC1=O	10.1016/j.bmcl.2007.05.043
		11398860	176045	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	In vitro binding affinity towards human motilin receptorIn vitro binding affinity towards human motilin receptor	ChEMBL	560	8	3	10	0.4	NC(=O)[C@H](CCc1ccccc1)NC(=O)C1C=CC2(CCNCC2)n2c(=O)n(Cc3ccc4c(c3)OCO4)c(=O)n21	10.1021/jm0304865
		CHEMBL45905	176045	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	In vitro binding affinity towards human motilin receptorIn vitro binding affinity towards human motilin receptor	ChEMBL	560	8	3	10	0.4	NC(=O)[C@H](CCc1ccccc1)NC(=O)C1C=CC2(CCNCC2)n2c(=O)n(Cc3ccc4c(c3)OCO4)c(=O)n21	10.1021/jm0304865
		11995154	81088	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	566	7	6	7	1.7	CCC[C@@H]1NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC1=O	10.1021/jm0606600
		CHEMBL215532	81088	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	566	7	6	7	1.7	CCC[C@@H]1NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC1=O	10.1021/jm0606600
		25115201	158774	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	611	5	6	8	1.2	CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(Cl)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CNC2=NCCN2)NC1=O	10.1016/j.bmcl.2007.05.043
		CHEMBL409410	158774	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	611	5	6	8	1.2	CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(Cl)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CNC2=NCCN2)NC1=O	10.1016/j.bmcl.2007.05.043
		44432978	86974	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	586	5	6	6	1.3	CC(C)[C@H]1NC(=O)[C@@H](Cc2ccc(Cl)cc2)NCCOc2ccccc2CCCNC(=O)[C@H](CNC(N)=O)NC1=O	10.1016/j.bmcl.2007.05.043
		CHEMBL232359	86974	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	586	5	6	6	1.3	CC(C)[C@H]1NC(=O)[C@@H](Cc2ccc(Cl)cc2)NCCOc2ccccc2CCCNC(=O)[C@H](CNC(N)=O)NC1=O	10.1016/j.bmcl.2007.05.043
		11226476	81175	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	538	5	5	6	2.5	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2CCCNC1=O	10.1021/jm0606600
		CHEMBL215825	81175	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	538	5	5	6	2.5	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2CCCNC1=O	10.1021/jm0606600
		11994925	81065	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	522	5	4	5	2.8	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccccc2)NCCOc2ccccc2CCCNC1=O	10.1021/jm0606600
		CHEMBL215440	81065	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	522	5	4	5	2.8	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccccc2)NCCOc2ccccc2CCCNC1=O	10.1021/jm0606600
		44432980	146896	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	585	5	7	6	1.1	CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(Cl)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CNC(=N)N)NC1=O	10.1016/j.bmcl.2007.05.043
		CHEMBL392553	146896	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	585	5	7	6	1.1	CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(Cl)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CNC(=N)N)NC1=O	10.1016/j.bmcl.2007.05.043
		11398860	176045	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	In vitro binding affinity towards human motilin receptorIn vitro binding affinity towards human motilin receptor	ChEMBL	560	8	3	10	0.4	NC(=O)[C@H](CCc1ccccc1)NC(=O)C1C=CC2(CCNCC2)n2c(=O)n(Cc3ccc4c(c3)OCO4)c(=O)n21	10.1021/jm0304865
		CHEMBL45905	176045	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	In vitro binding affinity towards human motilin receptorIn vitro binding affinity towards human motilin receptor	ChEMBL	560	8	3	10	0.4	NC(=O)[C@H](CCc1ccccc1)NC(=O)C1C=CC2(CCNCC2)n2c(=O)n(Cc3ccc4c(c3)OCO4)c(=O)n21	10.1021/jm0304865
		11204067	86785	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	585	5	7	6	1.1	CC(C)[C@H]1NC(=O)[C@@H](Cc2ccc(Cl)cc2)NCCOc2ccccc2CCCNC(=O)[C@H](CNC(=N)N)NC1=O	10.1016/j.bmcl.2007.05.043
		CHEMBL232154	86785	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	585	5	7	6	1.1	CC(C)[C@H]1NC(=O)[C@@H](Cc2ccc(Cl)cc2)NCCOc2ccccc2CCCNC(=O)[C@H](CNC(=N)N)NC1=O	10.1016/j.bmcl.2007.05.043
		44432975	87740	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	591	5	5	6	2.2	CNC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2cccc(C(F)(F)F)c2)NCCOc2ccccc2CCCNC1=O	10.1016/j.bmcl.2007.05.043
		CHEMBL233711	87740	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	591	5	5	6	2.2	CNC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2cccc(C(F)(F)F)c2)NCCOc2ccccc2CCCNC1=O	10.1016/j.bmcl.2007.05.043
		44432977	151680	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	619	5	7	6	1.5	CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(C(F)(F)F)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CNC(=N)N)NC1=O	10.1016/j.bmcl.2007.05.043
		CHEMBL396413	151680	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	619	5	7	6	1.5	CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(C(F)(F)F)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CNC(=N)N)NC1=O	10.1016/j.bmcl.2007.05.043
		11168753	144951	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	543	4	5	6	1.6	CC(C)[C@H]1NC(=O)[C@@H](Cc2ccc(Cl)cc2)NCCOc2ccccc2CCCNC(=O)[C@H](CN)NC1=O	10.1016/j.bmcl.2007.05.043
		CHEMBL391045	144951	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	543	4	5	6	1.6	CC(C)[C@H]1NC(=O)[C@@H](Cc2ccc(Cl)cc2)NCCOc2ccccc2CCCNC(=O)[C@H](CN)NC1=O	10.1016/j.bmcl.2007.05.043
		11994802	81457	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	536	5	5	5	3.0	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCCCc2ccccc2CCNC1=O	10.1021/jm0606600
		CHEMBL215963	81457	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	536	5	5	5	3.0	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCCCc2ccccc2CCNC1=O	10.1021/jm0606600
		11994800	141792	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	536	5	5	5	3.0	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCc2ccccc2CCCCNC1=O	10.1021/jm0606600
		CHEMBL386187	141792	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	536	5	5	5	3.0	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCc2ccccc2CCCCNC1=O	10.1021/jm0606600
		11180385	81416	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	550	5	5	6	2.8	CC(C)C[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC1=O	10.1021/jm0606600
		CHEMBL215946	81416	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	550	5	5	6	2.8	CC(C)C[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC1=O	10.1021/jm0606600
		25114976	148013	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	594	5	4	7	2.5	CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(Cl)c2)NCCOc2ccccc2CCCNC(=O)[C@H](Cn2ccnc2)NC1=O	10.1016/j.bmcl.2007.05.043
		CHEMBL393439	148013	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	594	5	4	7	2.5	CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(Cl)c2)NCCOc2ccccc2CCCNC(=O)[C@H](Cn2ccnc2)NC1=O	10.1016/j.bmcl.2007.05.043
		44417633	141449	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	580	5	4	6	2.7	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)N(C(C)=O)CCOc2ccccc2CCCNC1=O	10.1021/jm0606600
		CHEMBL384188	141449	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	580	5	4	6	2.7	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)N(C(C)=O)CCOc2ccccc2CCCNC1=O	10.1021/jm0606600
		11398651	148130	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	543	4	5	6	1.6	CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(Cl)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CN)NC1=O	10.1016/j.bmcl.2007.05.043
		CHEMBL393541	148130	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	543	4	5	6	1.6	CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(Cl)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CN)NC1=O	10.1016/j.bmcl.2007.05.043
		11995156	141764	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	524	4	6	7	0.7	CC(C)[C@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC(=O)[C@H](CO)NC1=O	10.1021/jm0606600
		CHEMBL386036	141764	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	524	4	6	7	0.7	CC(C)[C@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC(=O)[C@H](CO)NC1=O	10.1021/jm0606600
		11994679	80394	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	565	7	6	7	1.9	CC(C)[C@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC(=O)[C@H](CCCCN)NC1=O	10.1021/jm0606600
		CHEMBL214508	80394	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	565	7	6	7	1.9	CC(C)[C@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC(=O)[C@H](CCCCN)NC1=O	10.1021/jm0606600
		11994679	80394	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	565	7	6	7	1.9	CC(C)[C@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC(=O)[C@H](CCCCN)NC1=O	10.1016/j.bmcl.2007.05.043
		CHEMBL214508	80394	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	565	7	6	7	1.9	CC(C)[C@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC(=O)[C@H](CCCCN)NC1=O	10.1016/j.bmcl.2007.05.043
		11994924	80410	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	444	5	5	5	1.4	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NC/C=C/CCNC1=O	10.1021/jm0606600
		CHEMBL214555	80410	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	444	5	5	5	1.4	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NC/C=C/CCNC1=O	10.1021/jm0606600
		44417743	166107	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	548	5	5	5	3.5	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCCc2ccccc2/C=C\CCNC1=O	10.1021/jm0606600
		CHEMBL425988	166107	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	548	5	5	5	3.5	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCCc2ccccc2/C=C\CCNC1=O	10.1021/jm0606600
		11203197	80593	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	520	5	4	5	2.8	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccccc2)NCCOc2ccccc2/C=C/CNC1=O	10.1021/jm0606600
		CHEMBL215016	80593	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	520	5	4	5	2.8	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccccc2)NCCOc2ccccc2/C=C/CNC1=O	10.1021/jm0606600
		11994927	81764	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	572	5	4	5	3.9	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NCCOc2ccccc2CCCNC1=O	10.1021/jm0606600
		CHEMBL216400	81764	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	572	5	4	5	3.9	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NCCOc2ccccc2CCCNC1=O	10.1021/jm0606600
		11341873	141504	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	552	6	4	6	2.8	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(OC)cc2)NCCOc2ccccc2CCCNC1=O	10.1021/jm0606600
		CHEMBL384501	141504	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	552	6	4	6	2.8	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(OC)cc2)NCCOc2ccccc2CCCNC1=O	10.1021/jm0606600
		11433096	141603	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	572	5	4	5	3.9	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2cccc3ccccc23)NCCOc2ccccc2CCCNC1=O	10.1021/jm0606600
		CHEMBL385087	141603	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	572	5	4	5	3.9	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2cccc3ccccc23)NCCOc2ccccc2CCCNC1=O	10.1021/jm0606600
		25115427	98658	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	625	5	6	8	1.5	CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(Cl)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CNC2=NCCCN2)NC1=O	10.1016/j.bmcl.2007.05.043
		CHEMBL277329	98658	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	625	5	6	8	1.5	CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(Cl)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CNC2=NCCCN2)NC1=O	10.1016/j.bmcl.2007.05.043
		44432967	145571	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	551	6	6	7	1.5	CC(C)[C@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC(=O)[C@H](CCCN)NC1=O	10.1016/j.bmcl.2007.05.043
		CHEMBL391524	145571	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [125I]motilin from human motilin receptor expressed in CHO cellsDisplacement of [125I]motilin from human motilin receptor expressed in CHO cells	ChEMBL	551	6	6	7	1.5	CC(C)[C@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2/C=C/CNC(=O)[C@H](CCCN)NC1=O	10.1016/j.bmcl.2007.05.043
		11995259	80768	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	520	5	5	5	2.7	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCc2ccccc2/C=C/CNC1=O	10.1021/jm0606600
		CHEMBL215177	80768	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	520	5	5	5	2.7	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCc2ccccc2/C=C/CNC1=O	10.1021/jm0606600
		11995261	80766	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	524	5	5	6	2.1	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2CCNC1=O	10.1021/jm0606600
		CHEMBL215169	80766	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [125I]motilin from human MOTRDisplacement of [125I]motilin from human MOTR	ChEMBL	524	5	5	6	2.1	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2CCNC1=O	10.1021/jm0606600
		101635584	2596	31	None	-	1	Human	10.0	pKd	=	10	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10381885
		1458	2596	31	None	-	1	Human	10.0	pKd	=	10	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10381885
		16136567	2596	31	None	-	1	Human	10.0	pKd	=	10	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10381885
		3794	2596	31	None	-	1	Human	10.0	pKd	=	10	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10381885
		91898963	2596	31	None	-	1	Human	10.0	pKd	=	10	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10381885
		CHEMBL525634	2596	31	None	-	1	Human	10.0	pKd	=	10	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10381885
		1048	1585	76	None	-	1	Human	8.4	pKi	=	8.4	Binding	In vitro binding affinity towards human motilin receptorIn vitro binding affinity towards human motilin receptor	Drug Central	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	None
		12560	1585	76	None	-	1	Human	8.4	pKi	=	8.4	Binding	In vitro binding affinity towards human motilin receptorIn vitro binding affinity towards human motilin receptor	Drug Central	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	None
		1456	1585	76	None	-	1	Human	8.4	pKi	=	8.4	Binding	In vitro binding affinity towards human motilin receptorIn vitro binding affinity towards human motilin receptor	Drug Central	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	None
		CHEMBL532	1585	76	None	-	1	Human	8.4	pKi	=	8.4	Binding	In vitro binding affinity towards human motilin receptorIn vitro binding affinity towards human motilin receptor	Drug Central	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	None
		DB00199	1585	76	None	-	1	Human	8.4	pKi	=	8.4	Binding	In vitro binding affinity towards human motilin receptorIn vitro binding affinity towards human motilin receptor	Drug Central	733	7	5	14	1.8	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)O	None
		2139	3855	56	None	1	4	Rat	8.1	pKi	=	8.1	Binding	Inhibitory constant against thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells upon incubation at 37 degree C for 1 hr at pH 7.4 using [3H]Ntau(1)-Me-His-TRHInhibitory constant against thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells upon incubation at 37 degree C for 1 hr at pH 7.4 using [3H]Ntau(1)-Me-His-TRH	Drug Central		None	None	None		None	None
		2316	3855	56	None	1	4	Rat	8.1	pKi	=	8.1	Binding	Inhibitory constant against thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells upon incubation at 37 degree C for 1 hr at pH 7.4 using [3H]Ntau(1)-Me-His-TRHInhibitory constant against thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells upon incubation at 37 degree C for 1 hr at pH 7.4 using [3H]Ntau(1)-Me-His-TRH	Drug Central		None	None	None		None	None
		3836	3855	56	None	1	4	Rat	8.1	pKi	=	8.1	Binding	Inhibitory constant against thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells upon incubation at 37 degree C for 1 hr at pH 7.4 using [3H]Ntau(1)-Me-His-TRHInhibitory constant against thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells upon incubation at 37 degree C for 1 hr at pH 7.4 using [3H]Ntau(1)-Me-His-TRH	Drug Central		None	None	None		None	None
		638678	3855	56	None	1	4	Rat	8.1	pKi	=	8.1	Binding	Inhibitory constant against thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells upon incubation at 37 degree C for 1 hr at pH 7.4 using [3H]Ntau(1)-Me-His-TRHInhibitory constant against thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells upon incubation at 37 degree C for 1 hr at pH 7.4 using [3H]Ntau(1)-Me-His-TRH	Drug Central		None	None	None		None	None
		CHEMBL1472	3855	56	None	1	4	Rat	8.1	pKi	=	8.1	Binding	Inhibitory constant against thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells upon incubation at 37 degree C for 1 hr at pH 7.4 using [3H]Ntau(1)-Me-His-TRHInhibitory constant against thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells upon incubation at 37 degree C for 1 hr at pH 7.4 using [3H]Ntau(1)-Me-His-TRH	Drug Central		None	None	None		None	None
		DB09421	3855	56	None	1	4	Rat	8.1	pKi	=	8.1	Binding	Inhibitory constant against thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells upon incubation at 37 degree C for 1 hr at pH 7.4 using [3H]Ntau(1)-Me-His-TRHInhibitory constant against thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells upon incubation at 37 degree C for 1 hr at pH 7.4 using [3H]Ntau(1)-Me-His-TRH	Drug Central		None	None	None		None	None
		101635584	2596	31	None	-	1	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11461914
		101635584	2596	31	None	-	1	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11781320
		101635584	2596	31	None	-	1	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15677347
		101635584	2596	31	None	-	1	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	16531413
		1458	2596	31	None	-	1	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11461914
		1458	2596	31	None	-	1	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11781320
		1458	2596	31	None	-	1	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15677347
		1458	2596	31	None	-	1	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	16531413
		16136567	2596	31	None	-	1	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11461914
		16136567	2596	31	None	-	1	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11781320
		16136567	2596	31	None	-	1	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15677347
		16136567	2596	31	None	-	1	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	16531413
		3794	2596	31	None	-	1	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11461914
		3794	2596	31	None	-	1	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11781320
		3794	2596	31	None	-	1	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15677347
		3794	2596	31	None	-	1	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	16531413
		91898963	2596	31	None	-	1	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11461914
		91898963	2596	31	None	-	1	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11781320
		91898963	2596	31	None	-	1	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15677347
		91898963	2596	31	None	-	1	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	16531413
		CHEMBL525634	2596	31	None	-	1	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11461914
		CHEMBL525634	2596	31	None	-	1	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11781320
		CHEMBL525634	2596	31	None	-	1	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15677347
		CHEMBL525634	2596	31	None	-	1	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	16531413
		1450	3625	0	None	-	1	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15677347
		1451	3628	0	None	-	1	Human	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15677347
		1452	709	0	None	-	1	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11461914

Join us

Cite us

Main reference

Ligand source activities (1 row/activity)