Ligand source activities (1 row/activity)





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DOI

90644395 118925 0 None - 1 Rat 7.0 pEC50 = 7.0 Functional
Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay
ChEMBL 469 6 2 5 5.2 COc1ccccc1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1cccc2ccccc12 10.1021/jm5003843
CHEMBL3290102 118925 0 None - 1 Rat 7.0 pEC50 = 7.0 Functional
Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay
ChEMBL 469 6 2 5 5.2 COc1ccccc1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1cccc2ccccc12 10.1021/jm5003843
1574 9585 20 None -275 6 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human NTS2 receptor expressed in HEK293 cells assessed as inhibition of constitutive activity on MAPK-mediated luciferase activityAgonist activity at human NTS2 receptor expressed in HEK293 cells assessed as inhibition of constitutive activity on MAPK-mediated luciferase activity
ChEMBL None None None None 10.1021/jm200006c
1579 9585 20 None -275 6 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human NTS2 receptor expressed in HEK293 cells assessed as inhibition of constitutive activity on MAPK-mediated luciferase activityAgonist activity at human NTS2 receptor expressed in HEK293 cells assessed as inhibition of constitutive activity on MAPK-mediated luciferase activity
ChEMBL None None None None 10.1021/jm200006c
25077406 9585 20 None -275 6 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human NTS2 receptor expressed in HEK293 cells assessed as inhibition of constitutive activity on MAPK-mediated luciferase activityAgonist activity at human NTS2 receptor expressed in HEK293 cells assessed as inhibition of constitutive activity on MAPK-mediated luciferase activity
ChEMBL None None None None 10.1021/jm200006c
3830 9585 20 None -275 6 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human NTS2 receptor expressed in HEK293 cells assessed as inhibition of constitutive activity on MAPK-mediated luciferase activityAgonist activity at human NTS2 receptor expressed in HEK293 cells assessed as inhibition of constitutive activity on MAPK-mediated luciferase activity
ChEMBL None None None None 10.1021/jm200006c
CHEMBL407196 9585 20 None -275 6 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human NTS2 receptor expressed in HEK293 cells assessed as inhibition of constitutive activity on MAPK-mediated luciferase activityAgonist activity at human NTS2 receptor expressed in HEK293 cells assessed as inhibition of constitutive activity on MAPK-mediated luciferase activity
ChEMBL None None None None 10.1021/jm200006c
90644399 118929 1 None - 1 Rat 7.9 pEC50 = 7.9 Functional
Partial agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayPartial agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay
ChEMBL 437 6 2 5 4.2 COc1ccccc1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1ccc(F)cc1 10.1021/jm5003843
CHEMBL3290106 118929 1 None - 1 Rat 7.9 pEC50 = 7.9 Functional
Partial agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayPartial agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay
ChEMBL 437 6 2 5 4.2 COc1ccccc1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1ccc(F)cc1 10.1021/jm5003843
119192 9259 54 None -1 4 Rat 6.9 pEC50 = 6.9 Functional
Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1021/jm5003843
1582 9259 54 None -1 4 Rat 6.9 pEC50 = 6.9 Functional
Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1021/jm5003843
CHEMBL506981 9259 54 None -1 4 Rat 6.9 pEC50 = 6.9 Functional
Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1021/jm5003843
DB06455 9259 54 None -1 4 Rat 6.9 pEC50 = 6.9 Functional
Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1021/jm5003843
118721825 122864 0 None - 1 Rat 7.9 pEC50 = 7.9 Functional
Agonist activity at rat neurotensin receptor type 2 expressed in CHOK1 cells assessed as increase in calcium release by FLIPR assayAgonist activity at rat neurotensin receptor type 2 expressed in CHOK1 cells assessed as increase in calcium release by FLIPR assay
ChEMBL 457 8 2 6 4.2 COc1cccc(OC)c1-c1nc(C(=O)N[C@@H](CC(C)C)C(=O)O)nc2ccc(Cl)cc12 10.1016/j.bmcl.2014.11.047
CHEMBL3356854 122864 0 None - 1 Rat 7.9 pEC50 = 7.9 Functional
Agonist activity at rat neurotensin receptor type 2 expressed in CHOK1 cells assessed as increase in calcium release by FLIPR assayAgonist activity at rat neurotensin receptor type 2 expressed in CHOK1 cells assessed as increase in calcium release by FLIPR assay
ChEMBL 457 8 2 6 4.2 COc1cccc(OC)c1-c1nc(C(=O)N[C@@H](CC(C)C)C(=O)O)nc2ccc(Cl)cc12 10.1016/j.bmcl.2014.11.047
118721824 122863 0 None - 1 Rat 6.8 pEC50 = 6.8 Functional
Agonist activity at rat neurotensin receptor type 2 expressed in CHOK1 cells assessed as increase in calcium release by FLIPR assayAgonist activity at rat neurotensin receptor type 2 expressed in CHOK1 cells assessed as increase in calcium release by FLIPR assay
ChEMBL 469 6 2 6 4.5 COc1cccc(OC)c1-c1nc(C(=O)NC2(C(=O)O)CCCCC2)nc2ccc(Cl)cc12 10.1016/j.bmcl.2014.11.047
CHEMBL3356853 122863 0 None - 1 Rat 6.8 pEC50 = 6.8 Functional
Agonist activity at rat neurotensin receptor type 2 expressed in CHOK1 cells assessed as increase in calcium release by FLIPR assayAgonist activity at rat neurotensin receptor type 2 expressed in CHOK1 cells assessed as increase in calcium release by FLIPR assay
ChEMBL 469 6 2 6 4.5 COc1cccc(OC)c1-c1nc(C(=O)NC2(C(=O)O)CCCCC2)nc2ccc(Cl)cc12 10.1016/j.bmcl.2014.11.047
90644392 118922 0 None - 1 Rat 6.8 pEC50 = 6.8 Functional
Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay
ChEMBL 513 8 2 6 5.5 COc1cccc(OC)c1-c1cc(C(=O)N[C@H](C(=O)O)C2CCCCC2)nn1-c1cccc2ccccc12 10.1021/jm5003843
CHEMBL3290099 118922 0 None - 1 Rat 6.8 pEC50 = 6.8 Functional
Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay
ChEMBL 513 8 2 6 5.5 COc1cccc(OC)c1-c1cc(C(=O)N[C@H](C(=O)O)C2CCCCC2)nn1-c1cccc2ccccc12 10.1021/jm5003843
90644386 118916 0 None - 1 Rat 6.8 pEC50 = 6.8 Functional
Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay
ChEMBL 524 6 2 5 5.8 O=C(N[C@H](C(=O)O)C1CCCCC1)c1cc(-c2c(F)cccc2F)n(-c2ccnc3cc(Cl)ccc23)n1 10.1021/jm5003843
CHEMBL3290093 118916 0 None - 1 Rat 6.8 pEC50 = 6.8 Functional
Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay
ChEMBL 524 6 2 5 5.8 O=C(N[C@H](C(=O)O)C1CCCCC1)c1cc(-c2c(F)cccc2F)n(-c2ccnc3cc(Cl)ccc23)n1 10.1021/jm5003843
90644394 118924 0 None - 1 Rat 7.8 pEC50 = 7.8 Functional
Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay
ChEMBL 499 7 2 6 5.2 COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1cccc2ccccc12 10.1021/jm5003843
CHEMBL3290101 118924 0 None - 1 Rat 7.8 pEC50 = 7.8 Functional
Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay
ChEMBL 499 7 2 6 5.2 COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1cccc2ccccc12 10.1021/jm5003843
1580 10437 46 None -1 2 Rat 7.8 pEC50 = 7.8 Functional
Agonist activity at rat neurotensin receptor type 2 expressed in CHOK1 cells assessed as increase in calcium release by FLIPR assayAgonist activity at rat neurotensin receptor type 2 expressed in CHOK1 cells assessed as increase in calcium release by FLIPR assay
ChEMBL 685 13 2 8 5.7 COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1016/j.bmcl.2014.11.047
5311451 10437 46 None -1 2 Rat 7.8 pEC50 = 7.8 Functional
Agonist activity at rat neurotensin receptor type 2 expressed in CHOK1 cells assessed as increase in calcium release by FLIPR assayAgonist activity at rat neurotensin receptor type 2 expressed in CHOK1 cells assessed as increase in calcium release by FLIPR assay
ChEMBL 685 13 2 8 5.7 COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1016/j.bmcl.2014.11.047
CHEMBL3040381 10437 46 None -1 2 Rat 7.8 pEC50 = 7.8 Functional
Agonist activity at rat neurotensin receptor type 2 expressed in CHOK1 cells assessed as increase in calcium release by FLIPR assayAgonist activity at rat neurotensin receptor type 2 expressed in CHOK1 cells assessed as increase in calcium release by FLIPR assay
ChEMBL 685 13 2 8 5.7 COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1016/j.bmcl.2014.11.047
90644398 118928 0 None - 1 Rat 7.7 pEC50 = 7.7 Functional
Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay
ChEMBL 467 7 2 6 4.2 COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1ccc(F)cc1 10.1021/jm5003843
CHEMBL3290105 118928 0 None - 1 Rat 7.7 pEC50 = 7.7 Functional
Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay
ChEMBL 467 7 2 6 4.2 COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1ccc(F)cc1 10.1021/jm5003843
1580 10437 46 None -1 2 Rat 7.7 pEC50 = 7.7 Functional
Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay
ChEMBL 685 13 2 8 5.7 COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1021/jm5003843
5311451 10437 46 None -1 2 Rat 7.7 pEC50 = 7.7 Functional
Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay
ChEMBL 685 13 2 8 5.7 COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1021/jm5003843
CHEMBL3040381 10437 46 None -1 2 Rat 7.7 pEC50 = 7.7 Functional
Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay
ChEMBL 685 13 2 8 5.7 COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1021/jm5003843
90644390 118920 0 None - 1 Rat 7.7 pEC50 = 7.7 Functional
Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay
ChEMBL 520 7 2 7 4.9 COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)CCCC2)nn1-c1ccnc2cc(Cl)ccc12 10.1021/jm5003843
CHEMBL3290097 118920 0 None - 1 Rat 7.7 pEC50 = 7.7 Functional
Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay
ChEMBL 520 7 2 7 4.9 COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)CCCC2)nn1-c1ccnc2cc(Cl)ccc12 10.1021/jm5003843
90644388 118918 0 None - 1 Rat 7.7 pEC50 = 7.7 Functional
Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay
ChEMBL 548 7 2 7 5.7 COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)CCCCCC2)nn1-c1ccnc2cc(Cl)ccc12 10.1021/jm5003843
CHEMBL3290095 118918 0 None - 1 Rat 7.7 pEC50 = 7.7 Functional
Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay
ChEMBL 548 7 2 7 5.7 COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)CCCCCC2)nn1-c1ccnc2cc(Cl)ccc12 10.1021/jm5003843
90644383 118913 0 None - 1 Rat 6.7 pEC50 = 6.7 Functional
Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay
ChEMBL 548 8 2 7 5.5 COc1ccc(OC)c(-c2cc(C(=O)N[C@H](C(=O)O)C3CCCCC3)nn2-c2ccnc3cc(Cl)ccc23)c1 10.1021/jm5003843
CHEMBL3290090 118913 0 None - 1 Rat 6.7 pEC50 = 6.7 Functional
Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay
ChEMBL 548 8 2 7 5.5 COc1ccc(OC)c(-c2cc(C(=O)N[C@H](C(=O)O)C3CCCCC3)nn2-c2ccnc3cc(Cl)ccc23)c1 10.1021/jm5003843
1581 10442 10 None - 1 Rat 6.7 pEC50 = 6.7 Functional
Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay
ChEMBL 548 8 2 7 5.5 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)N[C@@H](C1CCCCC1)C(=O)O)OC 10.1021/jm5003843
9915499 10442 10 None - 1 Rat 6.7 pEC50 = 6.7 Functional
Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay
ChEMBL 548 8 2 7 5.5 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)N[C@@H](C1CCCCC1)C(=O)O)OC 10.1021/jm5003843
CHEMBL461604 10442 10 None - 1 Rat 6.7 pEC50 = 6.7 Functional
Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay
ChEMBL 548 8 2 7 5.5 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)N[C@@H](C1CCCCC1)C(=O)O)OC 10.1021/jm5003843
1580 10437 46 None -1 2 Rat 7.7 pEC50 = 7.7 Functional
Agonist activity at rat NTS2 receptor expressed in CHO-K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at rat NTS2 receptor expressed in CHO-K1 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 685 13 2 8 5.7 COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1021/jm500857r
5311451 10437 46 None -1 2 Rat 7.7 pEC50 = 7.7 Functional
Agonist activity at rat NTS2 receptor expressed in CHO-K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at rat NTS2 receptor expressed in CHO-K1 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 685 13 2 8 5.7 COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1021/jm500857r
CHEMBL3040381 10437 46 None -1 2 Rat 7.7 pEC50 = 7.7 Functional
Agonist activity at rat NTS2 receptor expressed in CHO-K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at rat NTS2 receptor expressed in CHO-K1 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 685 13 2 8 5.7 COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1021/jm500857r
90644393 118923 0 None - 1 Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay
ChEMBL 483 7 2 5 5.5 COc1ccccc1-c1cc(C(=O)N[C@H](C(=O)O)C2CCCCC2)nn1-c1cccc2ccccc12 10.1021/jm5003843
CHEMBL3290100 118923 0 None - 1 Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay
ChEMBL 483 7 2 5 5.5 COc1ccccc1-c1cc(C(=O)N[C@H](C(=O)O)C2CCCCC2)nn1-c1cccc2ccccc12 10.1021/jm5003843
90644385 118915 0 None - 1 Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay
ChEMBL 518 7 2 6 5.5 COc1ccccc1-c1cc(C(=O)N[C@H](C(=O)O)C2CCCCC2)nn1-c1ccnc2cc(Cl)ccc12 10.1021/jm5003843
CHEMBL3290092 118915 0 None - 1 Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay
ChEMBL 518 7 2 6 5.5 COc1ccccc1-c1cc(C(=O)N[C@H](C(=O)O)C2CCCCC2)nn1-c1ccnc2cc(Cl)ccc12 10.1021/jm5003843
90644397 118927 0 None - 1 Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay
ChEMBL 481 8 2 6 4.5 COc1cccc(OC)c1-c1cc(C(=O)N[C@H](C(=O)O)C2CCCCC2)nn1-c1ccc(F)cc1 10.1021/jm5003843
CHEMBL3290104 118927 0 None - 1 Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay
ChEMBL 481 8 2 6 4.5 COc1cccc(OC)c1-c1cc(C(=O)N[C@H](C(=O)O)C2CCCCC2)nn1-c1ccc(F)cc1 10.1021/jm5003843
146159772 9091 33 None -3 2 Rat 7.6 pEC50 = 7.6 Functional
Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay
ChEMBL 420 4 1 3 4.9 N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F 10.1021/jm5003843
1564 9091 33 None -3 2 Rat 7.6 pEC50 = 7.6 Functional
Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay
ChEMBL 420 4 1 3 4.9 N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F 10.1021/jm5003843
1586 9091 33 None -3 2 Rat 7.6 pEC50 = 7.6 Functional
Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay
ChEMBL 420 4 1 3 4.9 N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F 10.1021/jm5003843
54385 9091 33 None -3 2 Rat 7.6 pEC50 = 7.6 Functional
Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay
ChEMBL 420 4 1 3 4.9 N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F 10.1021/jm5003843
CHEMBL1615438 9091 33 None -3 2 Rat 7.6 pEC50 = 7.6 Functional
Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay
ChEMBL 420 4 1 3 4.9 N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F 10.1021/jm5003843
DB01106 9091 33 None -3 2 Rat 7.6 pEC50 = 7.6 Functional
Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay
ChEMBL 420 4 1 3 4.9 N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F 10.1021/jm5003843
90644389 118919 0 None - 1 Rat 7.5 pEC50 = 7.5 Functional
Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay
ChEMBL 534 7 2 7 5.3 COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1ccnc2cc(Cl)ccc12 10.1021/jm5003843
CHEMBL3290096 118919 0 None - 1 Rat 7.5 pEC50 = 7.5 Functional
Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay
ChEMBL 534 7 2 7 5.3 COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1ccnc2cc(Cl)ccc12 10.1021/jm5003843
127051280 147503 2 None -2 2 Rat 5.5 pEC50 = 5.5 Functional
Partial agonist activity at rat NTS2 receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayPartial agonist activity at rat NTS2 receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 523 11 2 6 5.6 COc1cccc(OC)c1-c1cc(C(=O)N[C@@H](CCC2CCCCC2)CC(=O)O)nn1-c1ccc(F)cc1 10.1016/j.bmc.2016.06.018
CHEMBL3817879 147503 2 None -2 2 Rat 5.5 pEC50 = 5.5 Functional
Partial agonist activity at rat NTS2 receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayPartial agonist activity at rat NTS2 receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 523 11 2 6 5.6 COc1cccc(OC)c1-c1cc(C(=O)N[C@@H](CCC2CCCCC2)CC(=O)O)nn1-c1ccc(F)cc1 10.1016/j.bmc.2016.06.018
127051011 147555 0 None 28 2 Rat 6.5 pEC50 = 6.5 Functional
Partial agonist activity at rat NTS2 receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayPartial agonist activity at rat NTS2 receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 495 9 2 6 4.8 COc1cccc(OC)c1-c1cc(C(=O)N[C@H](CC(=O)O)C2CCCCC2)nn1-c1ccc(F)cc1 10.1016/j.bmc.2016.06.018
CHEMBL3818506 147555 0 None 28 2 Rat 6.5 pEC50 = 6.5 Functional
Partial agonist activity at rat NTS2 receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayPartial agonist activity at rat NTS2 receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 495 9 2 6 4.8 COc1cccc(OC)c1-c1cc(C(=O)N[C@H](CC(=O)O)C2CCCCC2)nn1-c1ccc(F)cc1 10.1016/j.bmc.2016.06.018
90644384 118914 0 None - 1 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay
ChEMBL 548 8 2 7 5.5 COc1ccc(-c2cc(C(=O)N[C@H](C(=O)O)C3CCCCC3)nn2-c2ccnc3cc(Cl)ccc23)c(OC)c1 10.1021/jm5003843
CHEMBL3290091 118914 0 None - 1 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay
ChEMBL 548 8 2 7 5.5 COc1ccc(-c2cc(C(=O)N[C@H](C(=O)O)C3CCCCC3)nn2-c2ccnc3cc(Cl)ccc23)c(OC)c1 10.1021/jm5003843
CHEMBL1766825 215638 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human NTS2 receptor expressed in HEK293 cells assessed as inhibition of constitutive activity on MAPK-mediated luciferase activityAgonist activity at human NTS2 receptor expressed in HEK293 cells assessed as inhibition of constitutive activity on MAPK-mediated luciferase activity
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)CN(CCc1ccc(O)cc1)C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm200006c
118729840 124723 0 None - 1 Rat 7.3 pEC50 = 7.3 Functional
Agonist activity at rat NTS2 overexpressed in CHO-k1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at rat NTS2 overexpressed in CHO-k1 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 467 7 2 6 4.7 COc1cccc(OC)c1-c1cc(NC(=O)C2(C(=O)O)CCCCC2)nn1-c1ccc(F)cc1 10.1016/j.bmcl.2015.03.083
CHEMBL3403507 124723 0 None - 1 Rat 7.3 pEC50 = 7.3 Functional
Agonist activity at rat NTS2 overexpressed in CHO-k1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at rat NTS2 overexpressed in CHO-k1 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 467 7 2 6 4.7 COc1cccc(OC)c1-c1cc(NC(=O)C2(C(=O)O)CCCCC2)nn1-c1ccc(F)cc1 10.1016/j.bmcl.2015.03.083
CHEMBL1766946 215657 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human NTS2 receptor expressed in HEK293 cells assessed as inhibition of constitutive activity on MAPK-mediated luciferase activityAgonist activity at human NTS2 receptor expressed in HEK293 cells assessed as inhibition of constitutive activity on MAPK-mediated luciferase activity
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)CN(CCc1ccc(O)cc1)C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm200006c
90644391 118921 0 None - 1 Rat 7.2 pEC50 = 7.2 Functional
Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay
ChEMBL 504 6 2 6 5.3 COc1ccccc1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1ccnc2cc(Cl)ccc12 10.1021/jm5003843
CHEMBL3290098 118921 0 None - 1 Rat 7.2 pEC50 = 7.2 Functional
Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay
ChEMBL 504 6 2 6 5.3 COc1ccccc1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1ccnc2cc(Cl)ccc12 10.1021/jm5003843
90644396 118926 0 None - 1 Rat 7.2 pEC50 = 7.2 Functional
Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay
ChEMBL 519 7 2 6 4.7 COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)C3CC4CC(C3)CC2C4)nn1-c1ccc(F)cc1 10.1021/jm5003843
CHEMBL3290103 118926 0 None - 1 Rat 7.2 pEC50 = 7.2 Functional
Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay
ChEMBL 519 7 2 6 4.7 COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)C3CC4CC(C3)CC2C4)nn1-c1ccc(F)cc1 10.1021/jm5003843
CHEMBL1766945 215656 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human NTS2 receptor expressed in HEK293 cells assessed as inhibition of constitutive activity on MAPK-mediated luciferase activityAgonist activity at human NTS2 receptor expressed in HEK293 cells assessed as inhibition of constitutive activity on MAPK-mediated luciferase activity
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)CN(CCc1ccc(O)cc1)C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm200006c
90644399 118929 1 None - 1 Rat 8.2 pEC50 = 8.2 Functional
Partial agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay relative to SR142948aPartial agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay relative to SR142948a
ChEMBL 437 6 2 5 4.2 COc1ccccc1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1ccc(F)cc1 10.1021/jm5003843
CHEMBL3290106 118929 1 None - 1 Rat 8.2 pEC50 = 8.2 Functional
Partial agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay relative to SR142948aPartial agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay relative to SR142948a
ChEMBL 437 6 2 5 4.2 COc1ccccc1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1ccc(F)cc1 10.1021/jm5003843
CHEMBL1766944 215655 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human NTS2 receptor expressed in HEK293 cells assessed as inhibition of constitutive activity on MAPK-mediated luciferase activityAgonist activity at human NTS2 receptor expressed in HEK293 cells assessed as inhibition of constitutive activity on MAPK-mediated luciferase activity
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)CN(CCc1ccc(O)cc1)C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm200006c
90644387 118917 0 None - 1 Rat 7.0 pEC50 = 7.0 Functional
Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay
ChEMBL 576 9 2 7 6.1 CCc1c(C(=O)N[C@H](C(=O)O)C2CCCCC2)nn(-c2ccnc3cc(Cl)ccc23)c1-c1c(OC)cccc1OC 10.1021/jm5003843
CHEMBL3290094 118917 0 None - 1 Rat 7.0 pEC50 = 7.0 Functional
Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay
ChEMBL 576 9 2 7 6.1 CCc1c(C(=O)N[C@H](C(=O)O)C2CCCCC2)nn(-c2ccnc3cc(Cl)ccc23)c1-c1c(OC)cccc1OC 10.1021/jm5003843
118729841 124724 0 None - 1 Rat 6.0 pEC50 = 6.0 Functional
Agonist activity at rat NTS2 overexpressed in CHO-k1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at rat NTS2 overexpressed in CHO-k1 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 437 6 2 5 4.7 COc1ccccc1-c1cc(NC(=O)C2(C(=O)O)CCCCC2)nn1-c1ccc(F)cc1 10.1016/j.bmcl.2015.03.083
CHEMBL3403508 124724 0 None - 1 Rat 6.0 pEC50 = 6.0 Functional
Agonist activity at rat NTS2 overexpressed in CHO-k1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at rat NTS2 overexpressed in CHO-k1 cells assessed as calcium mobilization by FLIPR assay
ChEMBL 437 6 2 5 4.7 COc1ccccc1-c1cc(NC(=O)C2(C(=O)O)CCCCC2)nn1-c1ccc(F)cc1 10.1016/j.bmcl.2015.03.083
118721826 122865 0 None - 1 Rat 6.0 pIC50 = 6.0 Functional
Antagonist activity at rat neurotensin receptor type 2 expressed in CHOK1 cells assessed as inhibition of SR142948a-induced calcium release by FLIPR assayAntagonist activity at rat neurotensin receptor type 2 expressed in CHOK1 cells assessed as inhibition of SR142948a-induced calcium release by FLIPR assay
ChEMBL 483 7 2 6 4.7 COc1cccc(OC)c1-c1nc(C(=O)N[C@H](C(=O)O)C2CCCCC2)nc2ccc(Cl)cc12 10.1016/j.bmcl.2014.11.047
CHEMBL3356855 122865 0 None - 1 Rat 6.0 pIC50 = 6.0 Functional
Antagonist activity at rat neurotensin receptor type 2 expressed in CHOK1 cells assessed as inhibition of SR142948a-induced calcium release by FLIPR assayAntagonist activity at rat neurotensin receptor type 2 expressed in CHOK1 cells assessed as inhibition of SR142948a-induced calcium release by FLIPR assay
ChEMBL 483 7 2 6 4.7 COc1cccc(OC)c1-c1nc(C(=O)N[C@H](C(=O)O)C2CCCCC2)nc2ccc(Cl)cc12 10.1016/j.bmcl.2014.11.047
1574 9585 20 None -338 6 Rat 6.9 pIC50 = 6.9 Functional
Antagonist activity at rat NTS2 receptor expressed in CHO-K1 cells assessed as inhibition of SR142948a-induced calcium mobilization by FLIPR assayAntagonist activity at rat NTS2 receptor expressed in CHO-K1 cells assessed as inhibition of SR142948a-induced calcium mobilization by FLIPR assay
ChEMBL None None None None 10.1021/jm500857r
1579 9585 20 None -338 6 Rat 6.9 pIC50 = 6.9 Functional
Antagonist activity at rat NTS2 receptor expressed in CHO-K1 cells assessed as inhibition of SR142948a-induced calcium mobilization by FLIPR assayAntagonist activity at rat NTS2 receptor expressed in CHO-K1 cells assessed as inhibition of SR142948a-induced calcium mobilization by FLIPR assay
ChEMBL None None None None 10.1021/jm500857r
25077406 9585 20 None -338 6 Rat 6.9 pIC50 = 6.9 Functional
Antagonist activity at rat NTS2 receptor expressed in CHO-K1 cells assessed as inhibition of SR142948a-induced calcium mobilization by FLIPR assayAntagonist activity at rat NTS2 receptor expressed in CHO-K1 cells assessed as inhibition of SR142948a-induced calcium mobilization by FLIPR assay
ChEMBL None None None None 10.1021/jm500857r
3830 9585 20 None -338 6 Rat 6.9 pIC50 = 6.9 Functional
Antagonist activity at rat NTS2 receptor expressed in CHO-K1 cells assessed as inhibition of SR142948a-induced calcium mobilization by FLIPR assayAntagonist activity at rat NTS2 receptor expressed in CHO-K1 cells assessed as inhibition of SR142948a-induced calcium mobilization by FLIPR assay
ChEMBL None None None None 10.1021/jm500857r
CHEMBL407196 9585 20 None -338 6 Rat 6.9 pIC50 = 6.9 Functional
Antagonist activity at rat NTS2 receptor expressed in CHO-K1 cells assessed as inhibition of SR142948a-induced calcium mobilization by FLIPR assayAntagonist activity at rat NTS2 receptor expressed in CHO-K1 cells assessed as inhibition of SR142948a-induced calcium mobilization by FLIPR assay
ChEMBL None None None None 10.1021/jm500857r
90644398 118928 0 None - 1 Rat 6.9 pIC50 = 6.9 Functional
Antagonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as inhibition of SR142948a-induced calcium release by FLIPR assayAntagonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as inhibition of SR142948a-induced calcium release by FLIPR assay
ChEMBL 467 7 2 6 4.2 COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1ccc(F)cc1 10.1021/jm5003843
CHEMBL3290105 118928 0 None - 1 Rat 6.9 pIC50 = 6.9 Functional
Antagonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as inhibition of SR142948a-induced calcium release by FLIPR assayAntagonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as inhibition of SR142948a-induced calcium release by FLIPR assay
ChEMBL 467 7 2 6 4.2 COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1ccc(F)cc1 10.1021/jm5003843
90644399 118929 1 None - 1 Rat 6.8 pIC50 = 6.8 Functional
Antagonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as inhibition of SR142948a-induced calcium release by FLIPR assayAntagonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as inhibition of SR142948a-induced calcium release by FLIPR assay
ChEMBL 437 6 2 5 4.2 COc1ccccc1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1ccc(F)cc1 10.1021/jm5003843
CHEMBL3290106 118929 1 None - 1 Rat 6.8 pIC50 = 6.8 Functional
Antagonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as inhibition of SR142948a-induced calcium release by FLIPR assayAntagonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as inhibition of SR142948a-induced calcium release by FLIPR assay
ChEMBL 437 6 2 5 4.2 COc1ccccc1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1ccc(F)cc1 10.1021/jm5003843
1574 9585 20 None -338 6 Rat 7.7 pIC50 = 7.7 Functional
Antagonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as inhibition of SR142948a-induced calcium release by FLIPR assayAntagonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as inhibition of SR142948a-induced calcium release by FLIPR assay
ChEMBL None None None None 10.1021/jm5003843
1579 9585 20 None -338 6 Rat 7.7 pIC50 = 7.7 Functional
Antagonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as inhibition of SR142948a-induced calcium release by FLIPR assayAntagonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as inhibition of SR142948a-induced calcium release by FLIPR assay
ChEMBL None None None None 10.1021/jm5003843
25077406 9585 20 None -338 6 Rat 7.7 pIC50 = 7.7 Functional
Antagonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as inhibition of SR142948a-induced calcium release by FLIPR assayAntagonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as inhibition of SR142948a-induced calcium release by FLIPR assay
ChEMBL None None None None 10.1021/jm5003843
3830 9585 20 None -338 6 Rat 7.7 pIC50 = 7.7 Functional
Antagonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as inhibition of SR142948a-induced calcium release by FLIPR assayAntagonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as inhibition of SR142948a-induced calcium release by FLIPR assay
ChEMBL None None None None 10.1021/jm5003843
CHEMBL407196 9585 20 None -338 6 Rat 7.7 pIC50 = 7.7 Functional
Antagonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as inhibition of SR142948a-induced calcium release by FLIPR assayAntagonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as inhibition of SR142948a-induced calcium release by FLIPR assay
ChEMBL None None None None 10.1021/jm5003843
118711921 120836 0 None - 1 Rat 5.5 pIC50 = 5.5 Functional
Antagonist activity at rat NTS2 receptor expressed in CHO-K1 cells assessed as inhibition of SR142948a-induced calcium mobilization by FLIPR assayAntagonist activity at rat NTS2 receptor expressed in CHO-K1 cells assessed as inhibition of SR142948a-induced calcium mobilization by FLIPR assay
ChEMBL 457 9 3 5 3.4 Cc1ccc(S(=O)(=O)Nc2ccc3c(ccn3CC(=O)N[C@@H](CC(C)C)C(=O)O)c2)cc1 10.1021/jm500857r
CHEMBL3326832 120836 0 None - 1 Rat 5.5 pIC50 = 5.5 Functional
Antagonist activity at rat NTS2 receptor expressed in CHO-K1 cells assessed as inhibition of SR142948a-induced calcium mobilization by FLIPR assayAntagonist activity at rat NTS2 receptor expressed in CHO-K1 cells assessed as inhibition of SR142948a-induced calcium mobilization by FLIPR assay
ChEMBL 457 9 3 5 3.4 Cc1ccc(S(=O)(=O)Nc2ccc3c(ccn3CC(=O)N[C@@H](CC(C)C)C(=O)O)c2)cc1 10.1021/jm500857r
101873359 120835 25 None - 1 Rat 7.4 pIC50 = 7.4 Functional
Antagonist activity at rat NTS2 receptor expressed in CHO-K1 cells assessed as inhibition of SR142948a-induced calcium mobilization by FLIPR assayAntagonist activity at rat NTS2 receptor expressed in CHO-K1 cells assessed as inhibition of SR142948a-induced calcium mobilization by FLIPR assay
ChEMBL 553 10 3 6 4.1 Cc1ccc(S(=O)(=O)Nc2ccc3c(c2)c(C(=O)C(F)(F)F)cn3CC(=O)N[C@@H](CC(C)C)C(=O)O)cc1 10.1021/jm500857r
CHEMBL3326831 120835 25 None - 1 Rat 7.4 pIC50 = 7.4 Functional
Antagonist activity at rat NTS2 receptor expressed in CHO-K1 cells assessed as inhibition of SR142948a-induced calcium mobilization by FLIPR assayAntagonist activity at rat NTS2 receptor expressed in CHO-K1 cells assessed as inhibition of SR142948a-induced calcium mobilization by FLIPR assay
ChEMBL 553 10 3 6 4.1 Cc1ccc(S(=O)(=O)Nc2ccc3c(c2)c(C(=O)C(F)(F)F)cn3CC(=O)N[C@@H](CC(C)C)C(=O)O)cc1 10.1021/jm500857r
1574 9585 20 None -338 6 Rat 7.4 pIC50 = 7.4 Functional
Antagonist activity at rat neurotensin receptor type 2 expressed in CHOK1 cells assessed as inhibition of SR142948a-induced calcium release by FLIPR assayAntagonist activity at rat neurotensin receptor type 2 expressed in CHOK1 cells assessed as inhibition of SR142948a-induced calcium release by FLIPR assay
ChEMBL None None None None 10.1016/j.bmcl.2014.11.047
1579 9585 20 None -338 6 Rat 7.4 pIC50 = 7.4 Functional
Antagonist activity at rat neurotensin receptor type 2 expressed in CHOK1 cells assessed as inhibition of SR142948a-induced calcium release by FLIPR assayAntagonist activity at rat neurotensin receptor type 2 expressed in CHOK1 cells assessed as inhibition of SR142948a-induced calcium release by FLIPR assay
ChEMBL None None None None 10.1016/j.bmcl.2014.11.047
25077406 9585 20 None -338 6 Rat 7.4 pIC50 = 7.4 Functional
Antagonist activity at rat neurotensin receptor type 2 expressed in CHOK1 cells assessed as inhibition of SR142948a-induced calcium release by FLIPR assayAntagonist activity at rat neurotensin receptor type 2 expressed in CHOK1 cells assessed as inhibition of SR142948a-induced calcium release by FLIPR assay
ChEMBL None None None None 10.1016/j.bmcl.2014.11.047
3830 9585 20 None -338 6 Rat 7.4 pIC50 = 7.4 Functional
Antagonist activity at rat neurotensin receptor type 2 expressed in CHOK1 cells assessed as inhibition of SR142948a-induced calcium release by FLIPR assayAntagonist activity at rat neurotensin receptor type 2 expressed in CHOK1 cells assessed as inhibition of SR142948a-induced calcium release by FLIPR assay
ChEMBL None None None None 10.1016/j.bmcl.2014.11.047
CHEMBL407196 9585 20 None -338 6 Rat 7.4 pIC50 = 7.4 Functional
Antagonist activity at rat neurotensin receptor type 2 expressed in CHOK1 cells assessed as inhibition of SR142948a-induced calcium release by FLIPR assayAntagonist activity at rat neurotensin receptor type 2 expressed in CHOK1 cells assessed as inhibition of SR142948a-induced calcium release by FLIPR assay
ChEMBL None None None None 10.1016/j.bmcl.2014.11.047
CHEMBL342252 218452 0 None -16 4 Rat 8.3 pIC50 = 8.3 Functional
Antagonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as inhibition of SR142948a-induced calcium release by FLIPR assayAntagonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as inhibition of SR142948a-induced calcium release by FLIPR assay
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm5003843
146159772 9091 33 None 3 2 Mouse 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central 420 4 1 3 4.9 N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F None
1564 9091 33 None 3 2 Mouse 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central 420 4 1 3 4.9 N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F None
1586 9091 33 None 3 2 Mouse 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central 420 4 1 3 4.9 N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F None
54385 9091 33 None 3 2 Mouse 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central 420 4 1 3 4.9 N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F None
CHEMBL1615438 9091 33 None 3 2 Mouse 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central 420 4 1 3 4.9 N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F None
DB01106 9091 33 None 3 2 Mouse 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central 420 4 1 3 4.9 N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F None
1578 9547 0 None 2 2 Mouse 8.7 pIC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9480852
9940301 9547 0 None 2 2 Mouse 8.7 pIC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9480852
1575 7948 0 None -1 3 Rat 6.1 pIC50 None 6.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10318778
101205709 10586 0 None -6 3 Rat 6.8 pIC50 None 6.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10318778
1573 10586 0 None -6 3 Rat 6.8 pIC50 None 6.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10318778
119192 9259 54 None -1 4 Mouse 7.1 pIC50 None 7.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 9480852
1582 9259 54 None -1 4 Mouse 7.1 pIC50 None 7.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 9480852
CHEMBL506981 9259 54 None -1 4 Mouse 7.1 pIC50 None 7.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 9480852
DB06455 9259 54 None -1 4 Mouse 7.1 pIC50 None 7.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 9480852
1584 8278 0 None - 1 Mouse 7.6 pIC50 None 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9480852
146159772 9091 33 None -3 2 Rat 8.0 pIC50 None 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 420 4 1 3 4.9 N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F 8647296
1564 9091 33 None -3 2 Rat 8.0 pIC50 None 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 420 4 1 3 4.9 N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F 8647296
1586 9091 33 None -3 2 Rat 8.0 pIC50 None 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 420 4 1 3 4.9 N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F 8647296
54385 9091 33 None -3 2 Rat 8.0 pIC50 None 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 420 4 1 3 4.9 N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F 8647296
CHEMBL1615438 9091 33 None -3 2 Rat 8.0 pIC50 None 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 420 4 1 3 4.9 N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F 8647296
DB01106 9091 33 None -3 2 Rat 8.0 pIC50 None 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 420 4 1 3 4.9 N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F 8647296
1574 9585 20 None -338 6 Rat 8.2 pIC50 None 8.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10318778
1579 9585 20 None -338 6 Rat 8.2 pIC50 None 8.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10318778
25077406 9585 20 None -338 6 Rat 8.2 pIC50 None 8.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10318778
3830 9585 20 None -338 6 Rat 8.2 pIC50 None 8.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10318778
CHEMBL407196 9585 20 None -338 6 Rat 8.2 pIC50 None 8.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10318778
1578 9547 0 None -2 2 Rat 8.3 pIC50 None 8.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8647296
9940301 9547 0 None -2 2 Rat 8.3 pIC50 None 8.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8647296
146159772 9091 33 None 3 2 Mouse 8.6 pIC50 None 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 420 4 1 3 4.9 N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F 9480852
1564 9091 33 None 3 2 Mouse 8.6 pIC50 None 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 420 4 1 3 4.9 N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F 9480852
1586 9091 33 None 3 2 Mouse 8.6 pIC50 None 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 420 4 1 3 4.9 N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F 9480852
54385 9091 33 None 3 2 Mouse 8.6 pIC50 None 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 420 4 1 3 4.9 N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F 9480852
CHEMBL1615438 9091 33 None 3 2 Mouse 8.6 pIC50 None 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 420 4 1 3 4.9 N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F 9480852
DB01106 9091 33 None 3 2 Mouse 8.6 pIC50 None 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 420 4 1 3 4.9 N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F 9480852
1574 9585 20 None -63 6 Mouse 8.6 pIC50 None 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9480852
1579 9585 20 None -63 6 Mouse 8.6 pIC50 None 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9480852
25077406 9585 20 None -63 6 Mouse 8.6 pIC50 None 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9480852
3830 9585 20 None -63 6 Mouse 8.6 pIC50 None 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9480852
CHEMBL407196 9585 20 None -63 6 Mouse 8.6 pIC50 None 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9480852
1587 10877 0 None - 1 Mouse 8.8 pIC50 None 8.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9480852
16131039 10877 0 None - 1 Mouse 8.8 pIC50 None 8.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9480852
90470037 10877 0 None - 1 Mouse 8.8 pIC50 None 8.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9480852
1585 10642 0 None - 1 Mouse 8.9 pIC50 None 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9480852
1574 9585 20 None -338 6 Rat 9.1 pIC50 None 9.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8647296
1579 9585 20 None -338 6 Rat 9.1 pIC50 None 9.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8647296
25077406 9585 20 None -338 6 Rat 9.1 pIC50 None 9.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8647296
3830 9585 20 None -338 6 Rat 9.1 pIC50 None 9.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8647296
CHEMBL407196 9585 20 None -338 6 Rat 9.1 pIC50 None 9.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8647296




Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
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DOI

16127648 21137 0 None - 1 Human 7.3 pEC50 = 7.3 Binding
Binding affinity to human NTR2 by gamma countingBinding affinity to human NTR2 by gamma counting
ChEMBL 817 22 9 8 1.4 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)CCC[N+](C)(C)C)C(C)(C)C)C(=O)O 10.1021/jm100092s
CHEMBL1172376 21137 0 None - 1 Human 7.3 pEC50 = 7.3 Binding
Binding affinity to human NTR2 by gamma countingBinding affinity to human NTR2 by gamma counting
ChEMBL 817 22 9 8 1.4 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)CCC[N+](C)(C)C)C(C)(C)C)C(=O)O 10.1021/jm100092s
CHEMBL1200171 21137 0 None - 1 Human 7.3 pEC50 = 7.3 Binding
Binding affinity to human NTR2 by gamma countingBinding affinity to human NTR2 by gamma counting
ChEMBL 817 22 9 8 1.4 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)CCC[N+](C)(C)C)C(C)(C)C)C(=O)O 10.1021/jm100092s
44354086 123557 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2
ChEMBL 843 23 10 13 -1.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCN1CCN=C1N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
CHEMBL337721 123557 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2
ChEMBL 843 23 10 13 -1.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCN1CCN=C1N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
CHEMBL3622802 218660 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]-Tyr3-NT from human NTS2 receptor expressed in 1321N1 cell membranes incubated for 30 mins by gamma-counting based competitive radioligand binding assayDisplacement of [125I]-Tyr3-NT from human NTS2 receptor expressed in 1321N1 cell membranes incubated for 30 mins by gamma-counting based competitive radioligand binding assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](C[Si](C)(C)C)C(=O)O 10.1021/acs.jmedchem.5b00841
CHEMBL336836 218367 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2
ChEMBL None None None CCNC(=N)NCCC[C@H](N)C(=O)/N=C(/N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/jm0300633
CHEMBL258221 217295 17 None -2 2 Human 9.3 pIC50 = 9.3 Binding
Inhibition of human NTR2Inhibition of human NTR2
ChEMBL None None None None 10.1016/j.bmcl.2022.128983
44354244 175104 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2
ChEMBL 831 23 11 11 -1.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCC/N=C(/N)NC)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
CHEMBL434227 175104 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2
ChEMBL 831 23 11 11 -1.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCC/N=C(/N)NC)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
44354075 123544 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2
ChEMBL 803 24 10 11 -0.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
CHEMBL337644 123544 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2
ChEMBL 803 24 10 11 -0.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
44354087 29254 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2
ChEMBL 845 24 12 13 -1.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCNC1NCCN1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
CHEMBL132524 29254 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2
ChEMBL 845 24 12 13 -1.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCNC1NCCN1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
44354120 29117 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2
ChEMBL 816 23 11 11 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
CHEMBL132409 29117 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2
ChEMBL 816 23 11 11 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
CHEMBL258221 217295 17 None -2 2 Human 9.0 pIC50 = 9.0 Binding
Displacement of 125I-[Tyr3]-NT from human NTS2 receptorDisplacement of 125I-[Tyr3]-NT from human NTS2 receptor
ChEMBL None None None None 10.1021/acs.jmedchem.6b01848
1574 9585 20 None -15 6 Human 9.0 pIC50 = 9.0 Binding
Inhibition of human NTR2Inhibition of human NTR2
ChEMBL None None None None 10.1016/j.bmcl.2022.128983
1579 9585 20 None -15 6 Human 9.0 pIC50 = 9.0 Binding
Inhibition of human NTR2Inhibition of human NTR2
ChEMBL None None None None 10.1016/j.bmcl.2022.128983
25077406 9585 20 None -15 6 Human 9.0 pIC50 = 9.0 Binding
Inhibition of human NTR2Inhibition of human NTR2
ChEMBL None None None None 10.1016/j.bmcl.2022.128983
3830 9585 20 None -15 6 Human 9.0 pIC50 = 9.0 Binding
Inhibition of human NTR2Inhibition of human NTR2
ChEMBL None None None None 10.1016/j.bmcl.2022.128983
CHEMBL407196 9585 20 None -15 6 Human 9.0 pIC50 = 9.0 Binding
Inhibition of human NTR2Inhibition of human NTR2
ChEMBL None None None None 10.1016/j.bmcl.2022.128983
44354212 123479 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2
ChEMBL 803 24 10 11 -0.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCCNC)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
CHEMBL337260 123479 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2
ChEMBL 803 24 10 11 -0.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCCNC)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
11657884 122977 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2
ChEMBL 803 22 10 11 -0.1 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCCCN)C(C)(C)C)C(=O)O 10.1021/jm0300633
CHEMBL335846 122977 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2
ChEMBL 803 22 10 11 -0.1 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCCCN)C(C)(C)C)C(=O)O 10.1021/jm0300633
CHEMBL3622804 218662 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]-Tyr3-NT from human NTS2 receptor expressed in 1321N1 cell membranes incubated for 30 mins by gamma-counting based competitive radioligand binding assayDisplacement of [125I]-Tyr3-NT from human NTS2 receptor expressed in 1321N1 cell membranes incubated for 30 mins by gamma-counting based competitive radioligand binding assay
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](C[Si](C)(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1C[Si](C)(C)CN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCCN)C(=O)O 10.1021/acs.jmedchem.5b00841
44354245 174626 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2
ChEMBL 788 23 10 11 -0.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
CHEMBL430910 174626 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2
ChEMBL 788 23 10 11 -0.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
CHEMBL342252 218452 0 None -14 4 Human 8.6 pIC50 = 8.6 Binding
Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
44354085 29237 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2
ChEMBL 817 24 9 11 0.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCCN(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
CHEMBL132507 29237 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2
ChEMBL 817 24 9 11 0.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCCN(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
CHEMBL3622806 218664 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]-Tyr3-NT from human NTS2 receptor expressed in 1321N1 cell membranes incubated for 30 mins by gamma-counting based competitive radioligand binding assayDisplacement of [125I]-Tyr3-NT from human NTS2 receptor expressed in 1321N1 cell membranes incubated for 30 mins by gamma-counting based competitive radioligand binding assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1C[Si](C)(C)CN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.5b00841
CHEMBL3622803 218661 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]-Tyr3-NT from human NTS2 receptor expressed in 1321N1 cell membranes incubated for 30 mins by gamma-counting based competitive radioligand binding assayDisplacement of [125I]-Tyr3-NT from human NTS2 receptor expressed in 1321N1 cell membranes incubated for 30 mins by gamma-counting based competitive radioligand binding assay
ChEMBL None None None C[Si](C)(C)C[C@H](NC(=O)[C@H](C[Si](C)(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)O 10.1021/acs.jmedchem.5b00841
CHEMBL3622805 218663 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]-Tyr3-NT from human NTS2 receptor expressed in 1321N1 cell membranes incubated for 30 mins by gamma-counting based competitive radioligand binding assayDisplacement of [125I]-Tyr3-NT from human NTS2 receptor expressed in 1321N1 cell membranes incubated for 30 mins by gamma-counting based competitive radioligand binding assay
ChEMBL None None None CN[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C[Si](C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.5b00841
44354304 123833 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2
ChEMBL 774 22 10 11 -0.8 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
CHEMBL339139 123833 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2
ChEMBL 774 22 10 11 -0.8 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
44354211 29555 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2
ChEMBL 846 25 10 10 0.9 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)NC(=O)[C@@H](N)CCCCC[N+](C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
CHEMBL132794 29555 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2
ChEMBL 846 25 10 10 0.9 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)NC(=O)[C@@H](N)CCCCC[N+](C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
44354305 30786 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2
ChEMBL 832 24 10 10 0.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)NC(=O)[C@@H](N)CCCC[N+](C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
CHEMBL133798 30786 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2
ChEMBL 832 24 10 10 0.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)NC(=O)[C@@H](N)CCCC[N+](C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
44354303 30230 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2
ChEMBL 788 23 10 11 -0.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCNC)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
CHEMBL133340 30230 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2
ChEMBL 788 23 10 11 -0.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCNC)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
44354113 30868 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2
ChEMBL 831 25 9 11 0.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCCCN(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
CHEMBL133850 30868 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2
ChEMBL 831 25 9 11 0.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCCCN(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
CHEMBL439494 220621 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2
ChEMBL None None None None 10.1021/jm0300633
CHEMBL3622801 218659 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]-Tyr3-NT from human NTS2 receptor expressed in 1321N1 cell membranes incubated for 30 mins by gamma-counting based competitive radioligand binding assayDisplacement of [125I]-Tyr3-NT from human NTS2 receptor expressed in 1321N1 cell membranes incubated for 30 mins by gamma-counting based competitive radioligand binding assay
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](C[Si](C)(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)O 10.1021/acs.jmedchem.5b00841
CHEMBL3622806 218664 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of human NTR2Inhibition of human NTR2
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1C[Si](C)(C)CN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/j.bmcl.2022.128983
44354302 30283 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2
ChEMBL 803 23 9 11 -0.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCN(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
CHEMBL133378 30283 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2
ChEMBL 803 23 9 11 -0.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCN(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
44354154 26307 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2
ChEMBL 818 23 10 10 0.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)NC(=O)[C@@H](N)CCC[N+](C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
CHEMBL129953 26307 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2
ChEMBL 818 23 10 10 0.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)NC(=O)[C@@H](N)CCC[N+](C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
44354121 175264 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2
ChEMBL 826 22 10 10 0.7 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)NC(=O)[C@@H](N)CCCCCN)C(C)(C)C)C(=O)O 10.1021/jm0300633
CHEMBL435199 175264 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2
ChEMBL 826 22 10 10 0.7 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)NC(=O)[C@@H](N)CCCCCN)C(C)(C)C)C(=O)O 10.1021/jm0300633
44354112 30867 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2
ChEMBL 817 25 10 11 0.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCCCNC)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
CHEMBL133849 30867 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2
ChEMBL 817 25 10 11 0.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCCCNC)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
1569 8907 32 None -2 2 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]-Tyr3-NT from human NTS2 receptor expressed in 1321N1 cell membranes incubated for 30 mins by gamma-counting based competitive radioligand binding assayDisplacement of [125I]-Tyr3-NT from human NTS2 receptor expressed in 1321N1 cell membranes incubated for 30 mins by gamma-counting based competitive radioligand binding assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b00841
5311318 8907 32 None -2 2 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]-Tyr3-NT from human NTS2 receptor expressed in 1321N1 cell membranes incubated for 30 mins by gamma-counting based competitive radioligand binding assayDisplacement of [125I]-Tyr3-NT from human NTS2 receptor expressed in 1321N1 cell membranes incubated for 30 mins by gamma-counting based competitive radioligand binding assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b00841
CHEMBL415788 8907 32 None -2 2 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]-Tyr3-NT from human NTS2 receptor expressed in 1321N1 cell membranes incubated for 30 mins by gamma-counting based competitive radioligand binding assayDisplacement of [125I]-Tyr3-NT from human NTS2 receptor expressed in 1321N1 cell membranes incubated for 30 mins by gamma-counting based competitive radioligand binding assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b00841
CHEMBL1766928 215644 0 None -5 2 Human 8.9 pKd = 8.9 Binding
Displacement of [3H]NT from human NTS2 receptor expressed in HEK293 cellsDisplacement of [3H]NT from human NTS2 receptor expressed in HEK293 cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC1=CC=C(O)CC1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm200006c
CHEMBL342252 218452 0 None -14 4 Human 8.9 pKd = 8.9 Binding
Displacement of [3H]NT(8 to 13) from human NTS2 receptor expressed in HEK293 cellsDisplacement of [3H]NT(8 to 13) from human NTS2 receptor expressed in HEK293 cells
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm401491e
16127648 21137 0 None - 1 Rat 7.6 pKd = 7.6 Binding
Displacement of [125I]NT from rat NTR2 by gamma countingDisplacement of [125I]NT from rat NTR2 by gamma counting
ChEMBL 817 22 9 8 1.4 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)CCC[N+](C)(C)C)C(C)(C)C)C(=O)O 10.1021/jm100092s
CHEMBL1172376 21137 0 None - 1 Rat 7.6 pKd = 7.6 Binding
Displacement of [125I]NT from rat NTR2 by gamma countingDisplacement of [125I]NT from rat NTR2 by gamma counting
ChEMBL 817 22 9 8 1.4 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)CCC[N+](C)(C)C)C(C)(C)C)C(=O)O 10.1021/jm100092s
CHEMBL1200171 21137 0 None - 1 Rat 7.6 pKd = 7.6 Binding
Displacement of [125I]NT from rat NTR2 by gamma countingDisplacement of [125I]NT from rat NTR2 by gamma counting
ChEMBL 817 22 9 8 1.4 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)CCC[N+](C)(C)C)C(C)(C)C)C(=O)O 10.1021/jm100092s
162675694 190222 0 None 25 5 Human 10.5 pKi = 10.5 Binding
Displacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter methodDisplacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter method
ChEMBL 1422 36 20 16 -0.2 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2c(C)cc(O)cc2C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C)C1=O 10.1021/acs.jmedchem.0c01376
CHEMBL4798887 190222 0 None 25 5 Human 10.5 pKi = 10.5 Binding
Displacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter methodDisplacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter method
ChEMBL 1422 36 20 16 -0.2 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2c(C)cc(O)cc2C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C)C1=O 10.1021/acs.jmedchem.0c01376
162669697 189499 0 None 4 5 Human 10.1 pKi = 10.1 Binding
Displacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter methodDisplacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter method
ChEMBL 1394 36 20 16 -0.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C)C1=O 10.1021/acs.jmedchem.0c01376
CHEMBL4789659 189499 0 None 4 5 Human 10.1 pKi = 10.1 Binding
Displacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter methodDisplacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter method
ChEMBL 1394 36 20 16 -0.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C)C1=O 10.1021/acs.jmedchem.0c01376
162646561 186420 0 None 20 2 Human 10.0 pKi = 10.0 Binding
Displacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter methodDisplacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter method
ChEMBL 859 23 13 10 -0.1 Cc1cc(O)cc(C)c1C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)C[C@@H](N)CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C 10.1021/acs.jmedchem.0c01376
CHEMBL4742999 186420 0 None 20 2 Human 10.0 pKi = 10.0 Binding
Displacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter methodDisplacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter method
ChEMBL 859 23 13 10 -0.1 Cc1cc(O)cc(C)c1C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)C[C@@H](N)CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C 10.1021/acs.jmedchem.0c01376
162657942 187766 0 None 44 5 Human 9.8 pKi = 9.8 Binding
Displacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter methodDisplacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter method
ChEMBL 1366 36 16 16 1.5 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2c(C)cc(O)cc2C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C)C1=O 10.1021/acs.jmedchem.0c01376
CHEMBL4758754 187766 0 None 44 5 Human 9.8 pKi = 9.8 Binding
Displacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter methodDisplacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter method
ChEMBL 1366 36 16 16 1.5 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2c(C)cc(O)cc2C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C)C1=O 10.1021/acs.jmedchem.0c01376
162648776 186551 0 None 7 5 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter methodDisplacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter method
ChEMBL 1338 36 16 16 0.9 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C)C1=O 10.1021/acs.jmedchem.0c01376
CHEMBL4744531 186551 0 None 7 5 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter methodDisplacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter method
ChEMBL 1338 36 16 16 0.9 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C)C1=O 10.1021/acs.jmedchem.0c01376
162649599 186944 0 None 21 5 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter methodDisplacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter method
ChEMBL 1380 37 16 16 1.9 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N[C@@H](CCCCN)CC(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2c(C)cc(O)cc2C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C)C1=O 10.1021/acs.jmedchem.0c01376
CHEMBL4749016 186944 0 None 21 5 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter methodDisplacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter method
ChEMBL 1380 37 16 16 1.9 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N[C@@H](CCCCN)CC(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2c(C)cc(O)cc2C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C)C1=O 10.1021/acs.jmedchem.0c01376
162648890 186675 0 None 5 5 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter methodDisplacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter method
ChEMBL 1394 36 20 16 -0.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2cccc(O)c2)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C)C1=O 10.1021/acs.jmedchem.0c01376
CHEMBL4745899 186675 0 None 5 5 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter methodDisplacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter method
ChEMBL 1394 36 20 16 -0.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2cccc(O)c2)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C)C1=O 10.1021/acs.jmedchem.0c01376
155522777 183312 0 None 4 2 Human 9.3 pKi = 9.3 Binding
Displacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter methodDisplacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter method
ChEMBL 816 22 13 10 -1.1 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(C)(C)C)C(=O)O 10.1021/acs.jmedchem.0c01376
CHEMBL4452276 183312 0 None 4 2 Human 9.3 pKi = 9.3 Binding
Displacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter methodDisplacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter method
ChEMBL 816 22 13 10 -1.1 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(C)(C)C)C(=O)O 10.1021/acs.jmedchem.0c01376
CHEMBL4597094 183312 0 None 4 2 Human 9.3 pKi = 9.3 Binding
Displacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter methodDisplacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter method
ChEMBL 816 22 13 10 -1.1 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(C)(C)C)C(=O)O 10.1021/acs.jmedchem.0c01376
162649323 186796 0 None 7 5 Human 9.3 pKi = 9.3 Binding
Displacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter methodDisplacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter method
ChEMBL 1338 36 16 16 0.9 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2cccc(O)c2)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C)C1=O 10.1021/acs.jmedchem.0c01376
CHEMBL4747286 186796 0 None 7 5 Human 9.3 pKi = 9.3 Binding
Displacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter methodDisplacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter method
ChEMBL 1338 36 16 16 0.9 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2cccc(O)c2)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C)C1=O 10.1021/acs.jmedchem.0c01376
1569 8907 32 None -2 2 Human 9.3 pKi = 9.3 Binding
Displacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter methodDisplacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter method
ChEMBL None None None None 10.1021/acs.jmedchem.0c01376
5311318 8907 32 None -2 2 Human 9.3 pKi = 9.3 Binding
Displacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter methodDisplacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter method
ChEMBL None None None None 10.1021/acs.jmedchem.0c01376
CHEMBL415788 8907 32 None -2 2 Human 9.3 pKi = 9.3 Binding
Displacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter methodDisplacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter method
ChEMBL None None None None 10.1021/acs.jmedchem.0c01376
54582126 68063 0 None -2 2 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]NT from human NTS2 receptor expressed in HEK293 cellsDisplacement of [3H]NT from human NTS2 receptor expressed in HEK293 cells
ChEMBL 831 25 13 10 -0.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)C[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm200006c
CHEMBL1766935 68063 0 None -2 2 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]NT from human NTS2 receptor expressed in HEK293 cellsDisplacement of [3H]NT from human NTS2 receptor expressed in HEK293 cells
ChEMBL 831 25 13 10 -0.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)C[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm200006c
CHEMBL254769 217290 0 None 2 2 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]NT from human NTS2 receptor expressed in HEK293 cellsDisplacement of [3H]NT from human NTS2 receptor expressed in HEK293 cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)CNCCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm200006c
127032102 145976 0 None -1 2 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]NT(8 to 13 residues) from human NTSR2 expressed in HEK293 cell membranesDisplacement of [3H]NT(8 to 13 residues) from human NTSR2 expressed in HEK293 cell membranes
ChEMBL 931 28 14 11 -1.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3786852 145976 0 None -1 2 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]NT(8 to 13 residues) from human NTSR2 expressed in HEK293 cell membranesDisplacement of [3H]NT(8 to 13 residues) from human NTSR2 expressed in HEK293 cell membranes
ChEMBL 931 28 14 11 -1.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3787704 145976 0 None -1 2 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]NT(8 to 13 residues) from human NTSR2 expressed in HEK293 cell membranesDisplacement of [3H]NT(8 to 13 residues) from human NTSR2 expressed in HEK293 cell membranes
ChEMBL 931 28 14 11 -1.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.5b01495
1569 8907 32 None -2 2 Human 9.1 pKi = 9.1 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 2 in HEK293 cells homogenate incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 2 in HEK293 cells homogenate incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL None None None None 10.1021/acsmedchemlett.9b00462
5311318 8907 32 None -2 2 Human 9.1 pKi = 9.1 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 2 in HEK293 cells homogenate incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 2 in HEK293 cells homogenate incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL None None None None 10.1021/acsmedchemlett.9b00462
CHEMBL415788 8907 32 None -2 2 Human 9.1 pKi = 9.1 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 2 in HEK293 cells homogenate incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 2 in HEK293 cells homogenate incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL None None None None 10.1021/acsmedchemlett.9b00462
155547078 183315 0 None 3 2 Human 9.0 pKi = 9.0 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 2 in HEK293 cells homogenate incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 2 in HEK293 cells homogenate incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1456 42 15 15 5.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCOCCOCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL4534768 183315 0 None 3 2 Human 9.0 pKi = 9.0 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 2 in HEK293 cells homogenate incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 2 in HEK293 cells homogenate incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1456 42 15 15 5.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCOCCOCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL4597104 183315 0 None 3 2 Human 9.0 pKi = 9.0 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 2 in HEK293 cells homogenate incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 2 in HEK293 cells homogenate incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1456 42 15 15 5.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCOCCOCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
1569 8907 32 None -2 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]NT(8 to 13 residues) from human NTSR2 expressed in HEK293 cell membranesDisplacement of [3H]NT(8 to 13 residues) from human NTSR2 expressed in HEK293 cell membranes
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
5311318 8907 32 None -2 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]NT(8 to 13 residues) from human NTSR2 expressed in HEK293 cell membranesDisplacement of [3H]NT(8 to 13 residues) from human NTSR2 expressed in HEK293 cell membranes
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
CHEMBL415788 8907 32 None -2 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]NT(8 to 13 residues) from human NTSR2 expressed in HEK293 cell membranesDisplacement of [3H]NT(8 to 13 residues) from human NTSR2 expressed in HEK293 cell membranes
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
1569 8907 32 None -2 2 Human 8.9 pKi = 8.9 Binding
Displacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation countingDisplacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation counting
ChEMBL None None None None 10.1016/j.bmc.2016.10.039
5311318 8907 32 None -2 2 Human 8.9 pKi = 8.9 Binding
Displacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation countingDisplacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation counting
ChEMBL None None None None 10.1016/j.bmc.2016.10.039
CHEMBL415788 8907 32 None -2 2 Human 8.9 pKi = 8.9 Binding
Displacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation countingDisplacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation counting
ChEMBL None None None None 10.1016/j.bmc.2016.10.039
127030965 145981 0 None 5 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 2 in HEK293 cells homogenate incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 2 in HEK293 cells homogenate incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1396 38 14 12 6.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCCN1/C(=C\C=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
155559776 145981 0 None 5 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 2 in HEK293 cells homogenate incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 2 in HEK293 cells homogenate incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1396 38 14 12 6.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCCN1/C(=C\C=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL3787709 145981 0 None 5 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 2 in HEK293 cells homogenate incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 2 in HEK293 cells homogenate incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1396 38 14 12 6.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCCN1/C(=C\C=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL4564746 145981 0 None 5 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 2 in HEK293 cells homogenate incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 2 in HEK293 cells homogenate incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1396 38 14 12 6.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCCN1/C(=C\C=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
1569 8907 32 None -2 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]NT(8-13) from human NTSR2 expressed in HEK293 cell membranes by radioligand displacement assayDisplacement of [3H]NT(8-13) from human NTSR2 expressed in HEK293 cell membranes by radioligand displacement assay
ChEMBL None None None None 10.1016/j.bmc.2022.116720
5311318 8907 32 None -2 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]NT(8-13) from human NTSR2 expressed in HEK293 cell membranes by radioligand displacement assayDisplacement of [3H]NT(8-13) from human NTSR2 expressed in HEK293 cell membranes by radioligand displacement assay
ChEMBL None None None None 10.1016/j.bmc.2022.116720
CHEMBL415788 8907 32 None -2 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]NT(8-13) from human NTSR2 expressed in HEK293 cell membranes by radioligand displacement assayDisplacement of [3H]NT(8-13) from human NTSR2 expressed in HEK293 cell membranes by radioligand displacement assay
ChEMBL None None None None 10.1016/j.bmc.2022.116720
162647042 186393 0 None -1 5 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter methodDisplacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter method
ChEMBL 1406 33 19 16 -0.6 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2CCC[C@H]2C(=O)N2Cc3ccc(O)cc3C[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C)C1=O 10.1021/acs.jmedchem.0c01376
CHEMBL4742666 186393 0 None -1 5 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter methodDisplacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter method
ChEMBL 1406 33 19 16 -0.6 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2CCC[C@H]2C(=O)N2Cc3ccc(O)cc3C[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C)C1=O 10.1021/acs.jmedchem.0c01376
CHEMBL267714 217507 0 None 17 2 Human 8.0 pKi = 8 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.0c01726
162645305 186267 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 716 17 10 10 -0.6 CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1C/C=C\C[C@@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1)C(=O)O 10.1021/acs.jmedchem.0c01726
CHEMBL4740987 186267 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 716 17 10 10 -0.6 CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1C/C=C\C[C@@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1)C(=O)O 10.1021/acs.jmedchem.0c01726
CHEMBL1766943 215654 0 None 100 2 Human 7.0 pKi = 7 Binding
Displacement of [3H]NT from human NTS2 receptor expressed in HEK293 cellsDisplacement of [3H]NT from human NTS2 receptor expressed in HEK293 cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)CN(CCc1ccccn1)C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm200006c
CHEMBL254770 217291 0 None 30 2 Human 6.0 pKi = 6 Binding
Displacement of [3H]NT from human NTS2 receptor expressed in HEK293 cellsDisplacement of [3H]NT from human NTS2 receptor expressed in HEK293 cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)CN(Cc1ccc(O)cc1)C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm200006c
90644386 118916 0 None - 1 Rat 6.0 pKi = 6 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
ChEMBL 524 6 2 5 5.8 O=C(N[C@H](C(=O)O)C1CCCCC1)c1cc(-c2c(F)cccc2F)n(-c2ccnc3cc(Cl)ccc23)n1 10.1021/jm5003843
CHEMBL3290093 118916 0 None - 1 Rat 6.0 pKi = 6 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
ChEMBL 524 6 2 5 5.8 O=C(N[C@H](C(=O)O)C1CCCCC1)c1cc(-c2c(F)cccc2F)n(-c2ccnc3cc(Cl)ccc23)n1 10.1021/jm5003843
90644390 118920 0 None - 1 Rat 7.0 pKi = 7.0 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
ChEMBL 520 7 2 7 4.9 COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)CCCC2)nn1-c1ccnc2cc(Cl)ccc12 10.1021/jm5003843
CHEMBL3290097 118920 0 None - 1 Rat 7.0 pKi = 7.0 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
ChEMBL 520 7 2 7 4.9 COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)CCCC2)nn1-c1ccnc2cc(Cl)ccc12 10.1021/jm5003843
90644396 118926 0 None - 1 Rat 7.0 pKi = 7.0 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
ChEMBL 519 7 2 6 4.7 COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)C3CC4CC(C3)CC2C4)nn1-c1ccc(F)cc1 10.1021/jm5003843
CHEMBL3290103 118926 0 None - 1 Rat 7.0 pKi = 7.0 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
ChEMBL 519 7 2 6 4.7 COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)C3CC4CC(C3)CC2C4)nn1-c1ccc(F)cc1 10.1021/jm5003843
134144300 156979 0 None 45 2 Human 7.0 pKi = 7.0 Binding
Displacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation countingDisplacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation counting
ChEMBL 892 23 10 10 1.1 CC[C@H](C)[C@H](NC(=O)[C@]1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCCN)CCO[C@@H]1c1ccc(Br)cc1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/j.bmc.2016.10.039
CHEMBL3951982 156979 0 None 45 2 Human 7.0 pKi = 7.0 Binding
Displacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation countingDisplacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation counting
ChEMBL 892 23 10 10 1.1 CC[C@H](C)[C@H](NC(=O)[C@]1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCCN)CCO[C@@H]1c1ccc(Br)cc1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/j.bmc.2016.10.039
162667718 189309 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 716 17 10 10 -0.6 CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H]1C/C=C\C[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1)C(=O)O 10.1021/acs.jmedchem.0c01726
CHEMBL4787256 189309 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 716 17 10 10 -0.6 CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H]1C/C=C\C[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1)C(=O)O 10.1021/acs.jmedchem.0c01726
162664124 188850 0 None - 1 Human 5.0 pKi = 5.0 Binding
Binding affinity to NTS2 (unknown origin)Binding affinity to NTS2 (unknown origin)
ChEMBL 813 13 9 10 1.4 CC[C@H](C)[C@H](NC(=O)[C@@H]1Cc2ccc(O)c(c2)C/C=C/CNCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.0c01726
CHEMBL4781448 188850 0 None - 1 Human 5.0 pKi = 5.0 Binding
Binding affinity to NTS2 (unknown origin)Binding affinity to NTS2 (unknown origin)
ChEMBL 813 13 9 10 1.4 CC[C@H](C)[C@H](NC(=O)[C@@H]1Cc2ccc(O)c(c2)C/C=C/CNCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.0c01726
134138287 154615 0 None 3 2 Human 5.0 pKi = 5.0 Binding
Displacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation countingDisplacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation counting
ChEMBL 779 19 9 9 0.6 CC(C)C[C@H](NC(=O)C1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCCN)CCOC1c1ccc(Br)cc1)C(=O)O 10.1016/j.bmc.2016.10.039
CHEMBL3932989 154615 0 None 3 2 Human 5.0 pKi = 5.0 Binding
Displacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation countingDisplacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation counting
ChEMBL 779 19 9 9 0.6 CC(C)C[C@H](NC(=O)C1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCCN)CCOC1c1ccc(Br)cc1)C(=O)O 10.1016/j.bmc.2016.10.039
90644394 118924 0 None 10 2 Rat 6.9 pKi = 6.9 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
ChEMBL 499 7 2 6 5.2 COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1cccc2ccccc12 10.1021/jm5003843
CHEMBL3290101 118924 0 None 10 2 Rat 6.9 pKi = 6.9 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
ChEMBL 499 7 2 6 5.2 COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1cccc2ccccc12 10.1021/jm5003843
90644387 118917 0 None - 1 Rat 5.9 pKi = 5.9 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
ChEMBL 576 9 2 7 6.1 CCc1c(C(=O)N[C@H](C(=O)O)C2CCCCC2)nn(-c2ccnc3cc(Cl)ccc23)c1-c1c(OC)cccc1OC 10.1021/jm5003843
CHEMBL3290094 118917 0 None - 1 Rat 5.9 pKi = 5.9 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
ChEMBL 576 9 2 7 6.1 CCc1c(C(=O)N[C@H](C(=O)O)C2CCCCC2)nn(-c2ccnc3cc(Cl)ccc23)c1-c1c(OC)cccc1OC 10.1021/jm5003843
134145547 155753 0 None 72 2 Human 7.9 pKi = 7.9 Binding
Displacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation countingDisplacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation counting
ChEMBL 920 23 12 10 0.2 CC[C@H](C)[C@H](NC(=O)C1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)CCOC1c1ccc(Br)cc1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/j.bmc.2016.10.039
CHEMBL3942198 155753 0 None 72 2 Human 7.9 pKi = 7.9 Binding
Displacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation countingDisplacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation counting
ChEMBL 920 23 12 10 0.2 CC[C@H](C)[C@H](NC(=O)C1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)CCOC1c1ccc(Br)cc1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/j.bmc.2016.10.039
134155365 157972 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Displacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation countingDisplacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation counting
ChEMBL 859 23 13 11 -0.8 CC[C@H](C)[C@H](NC(=O)[C@]1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)CCO[C@@H]1c1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/j.bmc.2016.10.039
CHEMBL3959801 157972 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Displacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation countingDisplacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation counting
ChEMBL 859 23 13 11 -0.8 CC[C@H](C)[C@H](NC(=O)[C@]1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)CCO[C@@H]1c1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/j.bmc.2016.10.039
CHEMBL2369509 216409 0 None 5 2 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]NT from human NTS2 receptor expressed in HEK293 cellsDisplacement of [3H]NT from human NTS2 receptor expressed in HEK293 cells
ChEMBL None None None CC[C@H](C)N(CC(=O)N[C@@H](CC(C)C)C(=O)O)C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN 10.1021/jm200006c
118729839 124722 0 None 79 2 Rat 6.9 pKi = 6.9 Binding
Displacement of [I125]neurotensin from rat NTS2 overexpressed in CHO-k1 cells by competitive binding AssayDisplacement of [I125]neurotensin from rat NTS2 overexpressed in CHO-k1 cells by competitive binding Assay
ChEMBL 499 7 2 6 5.7 COc1cccc(OC)c1-c1cc(NC(=O)C2(C(=O)O)CCCCC2)nn1-c1cccc2ccccc12 10.1016/j.bmcl.2015.03.083
CHEMBL3403506 124722 0 None 79 2 Rat 6.9 pKi = 6.9 Binding
Displacement of [I125]neurotensin from rat NTS2 overexpressed in CHO-k1 cells by competitive binding AssayDisplacement of [I125]neurotensin from rat NTS2 overexpressed in CHO-k1 cells by competitive binding Assay
ChEMBL 499 7 2 6 5.7 COc1cccc(OC)c1-c1cc(NC(=O)C2(C(=O)O)CCCCC2)nn1-c1cccc2ccccc12 10.1016/j.bmcl.2015.03.083
162657409 187887 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 830 19 11 11 -0.0 CC[C@@H](C)[C@H](NC(=O)[C@@H]1C/C=C\C[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.0c01726
CHEMBL4760222 187887 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 830 19 11 11 -0.0 CC[C@@H](C)[C@H](NC(=O)[C@@H]1C/C=C\C[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.0c01726
CHEMBL1766927 215643 0 None -1 2 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]NT from human NTS2 receptor expressed in HEK293 cellsDisplacement of [3H]NT from human NTS2 receptor expressed in HEK293 cells
ChEMBL None None None None 10.1021/jm200006c
162660324 188044 0 None 51 2 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter methodDisplacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter method
ChEMBL 828 19 12 10 -0.9 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@@H]1Cc2cc(O)ccc2CN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(C)(C)C)C(=O)O 10.1021/acs.jmedchem.0c01376
CHEMBL4761958 188044 0 None 51 2 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter methodDisplacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter method
ChEMBL 828 19 12 10 -0.9 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@@H]1Cc2cc(O)ccc2CN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(C)(C)C)C(=O)O 10.1021/acs.jmedchem.0c01376
90644398 118928 0 None 22 2 Rat 6.9 pKi = 6.9 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
ChEMBL 467 7 2 6 4.2 COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1ccc(F)cc1 10.1021/jm5003843
CHEMBL3290105 118928 0 None 22 2 Rat 6.9 pKi = 6.9 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
ChEMBL 467 7 2 6 4.2 COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1ccc(F)cc1 10.1021/jm5003843
CHEMBL1766932 215648 0 None 6 2 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]NT from human NTS2 receptor expressed in HEK293 cellsDisplacement of [3H]NT from human NTS2 receptor expressed in HEK293 cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm200006c
118729838 124721 0 None 51 2 Rat 6.9 pKi = 6.9 Binding
Displacement of [I125]neurotensin from rat NTS2 overexpressed in CHO-k1 cells by competitive binding AssayDisplacement of [I125]neurotensin from rat NTS2 overexpressed in CHO-k1 cells by competitive binding Assay
ChEMBL 534 7 2 7 5.7 COc1cccc(OC)c1-c1cc(NC(=O)C2(C(=O)O)CCCCC2)nn1-c1ccnc2cc(Cl)ccc12 10.1016/j.bmcl.2015.03.083
CHEMBL3403505 124721 0 None 51 2 Rat 6.9 pKi = 6.9 Binding
Displacement of [I125]neurotensin from rat NTS2 overexpressed in CHO-k1 cells by competitive binding AssayDisplacement of [I125]neurotensin from rat NTS2 overexpressed in CHO-k1 cells by competitive binding Assay
ChEMBL 534 7 2 7 5.7 COc1cccc(OC)c1-c1cc(NC(=O)C2(C(=O)O)CCCCC2)nn1-c1ccnc2cc(Cl)ccc12 10.1016/j.bmcl.2015.03.083
90644385 118915 0 None - 1 Rat 5.9 pKi = 5.9 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
ChEMBL 518 7 2 6 5.5 COc1ccccc1-c1cc(C(=O)N[C@H](C(=O)O)C2CCCCC2)nn1-c1ccnc2cc(Cl)ccc12 10.1021/jm5003843
CHEMBL3290092 118915 0 None - 1 Rat 5.9 pKi = 5.9 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
ChEMBL 518 7 2 6 5.5 COc1ccccc1-c1cc(C(=O)N[C@H](C(=O)O)C2CCCCC2)nn1-c1ccnc2cc(Cl)ccc12 10.1021/jm5003843
134143837 157330 0 None 9 2 Human 5.8 pKi = 5.8 Binding
Displacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation countingDisplacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation counting
ChEMBL 807 19 11 9 -0.3 CC(C)C[C@H](NC(=O)C1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)CCOC1c1ccc(Br)cc1)C(=O)O 10.1016/j.bmc.2016.10.039
CHEMBL3954824 157330 0 None 9 2 Human 5.8 pKi = 5.8 Binding
Displacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation countingDisplacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation counting
ChEMBL 807 19 11 9 -0.3 CC(C)C[C@H](NC(=O)C1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)CCOC1c1ccc(Br)cc1)C(=O)O 10.1016/j.bmc.2016.10.039
134142369 152354 0 None 67 2 Human 6.8 pKi = 6.8 Binding
Displacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation countingDisplacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation counting
ChEMBL 892 23 10 10 1.1 CC[C@H](C)[C@H](NC(=O)[C@]1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCNC(=N)N)CCO[C@@H]1c1ccc(Br)cc1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/j.bmc.2016.10.039
CHEMBL3915284 152354 0 None 67 2 Human 6.8 pKi = 6.8 Binding
Displacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation countingDisplacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation counting
ChEMBL 892 23 10 10 1.1 CC[C@H](C)[C@H](NC(=O)[C@]1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCNC(=N)N)CCO[C@@H]1c1ccc(Br)cc1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/j.bmc.2016.10.039
162664045 188906 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 754 17 10 12 -0.5 CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1)C(=O)O 10.1021/acs.jmedchem.0c01726
CHEMBL4782113 188906 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 754 17 10 12 -0.5 CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1)C(=O)O 10.1021/acs.jmedchem.0c01726
118711921 120836 0 None - 1 Rat 5.8 pKi = 5.8 Binding
Displacement of [125I]neurotensin from rat NTS2 receptor expressed in CHO-K1 cells by competitive binding assayDisplacement of [125I]neurotensin from rat NTS2 receptor expressed in CHO-K1 cells by competitive binding assay
ChEMBL 457 9 3 5 3.4 Cc1ccc(S(=O)(=O)Nc2ccc3c(ccn3CC(=O)N[C@@H](CC(C)C)C(=O)O)c2)cc1 10.1021/jm500857r
CHEMBL3326832 120836 0 None - 1 Rat 5.8 pKi = 5.8 Binding
Displacement of [125I]neurotensin from rat NTS2 receptor expressed in CHO-K1 cells by competitive binding assayDisplacement of [125I]neurotensin from rat NTS2 receptor expressed in CHO-K1 cells by competitive binding assay
ChEMBL 457 9 3 5 3.4 Cc1ccc(S(=O)(=O)Nc2ccc3c(ccn3CC(=O)N[C@@H](CC(C)C)C(=O)O)c2)cc1 10.1021/jm500857r
90644389 118919 0 None 1 2 Rat 6.8 pKi = 6.8 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
ChEMBL 534 7 2 7 5.3 COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1ccnc2cc(Cl)ccc12 10.1021/jm5003843
CHEMBL3290096 118919 0 None 1 2 Rat 6.8 pKi = 6.8 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
ChEMBL 534 7 2 7 5.3 COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1ccnc2cc(Cl)ccc12 10.1021/jm5003843
90644399 118929 1 None - 1 Rat 6.8 pKi = 6.8 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
ChEMBL 437 6 2 5 4.2 COc1ccccc1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1ccc(F)cc1 10.1021/jm5003843
CHEMBL3290106 118929 1 None - 1 Rat 6.8 pKi = 6.8 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
ChEMBL 437 6 2 5 4.2 COc1ccccc1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1ccc(F)cc1 10.1021/jm5003843
90644384 118914 0 None - 1 Rat 5.8 pKi = 5.8 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
ChEMBL 548 8 2 7 5.5 COc1ccc(-c2cc(C(=O)N[C@H](C(=O)O)C3CCCCC3)nn2-c2ccnc3cc(Cl)ccc23)c(OC)c1 10.1021/jm5003843
CHEMBL3290091 118914 0 None - 1 Rat 5.8 pKi = 5.8 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
ChEMBL 548 8 2 7 5.5 COc1ccc(-c2cc(C(=O)N[C@H](C(=O)O)C3CCCCC3)nn2-c2ccnc3cc(Cl)ccc23)c(OC)c1 10.1021/jm5003843
162660488 188144 0 None 10 2 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 1646 51 24 21 -3.9 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.0c01726
CHEMBL4763222 188144 0 None 10 2 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 1646 51 24 21 -3.9 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.0c01726
54582127 68064 0 None -4 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]NT from human NTS2 receptor expressed in HEK293 cellsDisplacement of [3H]NT from human NTS2 receptor expressed in HEK293 cells
ChEMBL 831 25 13 10 -0.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)C[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm200006c
CHEMBL1766936 68064 0 None -4 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]NT from human NTS2 receptor expressed in HEK293 cellsDisplacement of [3H]NT from human NTS2 receptor expressed in HEK293 cells
ChEMBL 831 25 13 10 -0.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)C[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm200006c
137645783 164527 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of 125I-[Tyr3]-NT from human NTS2 receptor expressed in human 1321N1 cell membranes after 30 mins by gamma counting analysisDisplacement of 125I-[Tyr3]-NT from human NTS2 receptor expressed in human 1321N1 cell membranes after 30 mins by gamma counting analysis
ChEMBL 726 25 9 10 -0.5 CC[C@H](C)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.6b01848
CHEMBL4082440 164527 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of 125I-[Tyr3]-NT from human NTS2 receptor expressed in human 1321N1 cell membranes after 30 mins by gamma counting analysisDisplacement of 125I-[Tyr3]-NT from human NTS2 receptor expressed in human 1321N1 cell membranes after 30 mins by gamma counting analysis
ChEMBL 726 25 9 10 -0.5 CC[C@H](C)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.6b01848
CHEMBL1766940 215651 0 None 2 2 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]NT from human NTS2 receptor expressed in HEK293 cellsDisplacement of [3H]NT from human NTS2 receptor expressed in HEK293 cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N(CC(=O)O)CC(C)C 10.1021/jm200006c
134146201 155722 0 None 7 2 Human 4.8 pKi = 4.8 Binding
Displacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation countingDisplacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation counting
ChEMBL 779 19 9 9 0.6 CC(C)C[C@H](NC(=O)C1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCNC(=N)N)CCOC1c1ccc(Br)cc1)C(=O)O 10.1016/j.bmc.2016.10.039
CHEMBL3941970 155722 0 None 7 2 Human 4.8 pKi = 4.8 Binding
Displacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation countingDisplacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation counting
ChEMBL 779 19 9 9 0.6 CC(C)C[C@H](NC(=O)C1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCNC(=N)N)CCOC1c1ccc(Br)cc1)C(=O)O 10.1016/j.bmc.2016.10.039
CHEMBL253527 217289 0 None 12 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]NT from human NTS2 receptor expressed in HEK293 cellsDisplacement of [3H]NT from human NTS2 receptor expressed in HEK293 cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CCc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm200006c
168269036 196793 0 None -1 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]NT(8-13) from human NTSR2 expressed in HEK293 cell membranes by radioligand displacement assayDisplacement of [3H]NT(8-13) from human NTSR2 expressed in HEK293 cell membranes by radioligand displacement assay
ChEMBL 895 28 14 13 -1.4 CC(C)C[C@H](NC(=O)[C@@H](CCSSCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)O 10.1016/j.bmc.2022.116720
CHEMBL5171551 196793 0 None -1 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]NT(8-13) from human NTSR2 expressed in HEK293 cell membranes by radioligand displacement assayDisplacement of [3H]NT(8-13) from human NTSR2 expressed in HEK293 cell membranes by radioligand displacement assay
ChEMBL 895 28 14 13 -1.4 CC(C)C[C@H](NC(=O)[C@@H](CCSSCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)O 10.1016/j.bmc.2022.116720
90644388 118918 0 None - 1 Rat 6.8 pKi = 6.8 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
ChEMBL 548 7 2 7 5.7 COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)CCCCCC2)nn1-c1ccnc2cc(Cl)ccc12 10.1021/jm5003843
CHEMBL3290095 118918 0 None - 1 Rat 6.8 pKi = 6.8 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
ChEMBL 548 7 2 7 5.7 COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)CCCCCC2)nn1-c1ccnc2cc(Cl)ccc12 10.1021/jm5003843
1574 9585 20 None -107 6 Rat 7.7 pKi = 7.7 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
ChEMBL None None None None 10.1021/jm5003843
1579 9585 20 None -107 6 Rat 7.7 pKi = 7.7 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
ChEMBL None None None None 10.1021/jm5003843
25077406 9585 20 None -107 6 Rat 7.7 pKi = 7.7 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
ChEMBL None None None None 10.1021/jm5003843
3830 9585 20 None -107 6 Rat 7.7 pKi = 7.7 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
ChEMBL None None None None 10.1021/jm5003843
CHEMBL407196 9585 20 None -107 6 Rat 7.7 pKi = 7.7 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
ChEMBL None None None None 10.1021/jm5003843
134134595 150398 0 None 34 2 Human 5.7 pKi = 5.7 Binding
Displacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation countingDisplacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation counting
ChEMBL 808 21 8 10 0.6 CC(C)C[C@H](NC(=O)CNC(=O)C1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)CCOC1c1ccc(Br)cc1)C(=O)O 10.1016/j.bmc.2016.10.039
CHEMBL3899699 150398 0 None 34 2 Human 5.7 pKi = 5.7 Binding
Displacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation countingDisplacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation counting
ChEMBL 808 21 8 10 0.6 CC(C)C[C@H](NC(=O)CNC(=O)C1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)CCOC1c1ccc(Br)cc1)C(=O)O 10.1016/j.bmc.2016.10.039
127032412 145978 0 None -4 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]NT(8 to 13 residues) from human NTSR2 expressed in HEK293 cell membranesDisplacement of [3H]NT(8 to 13 residues) from human NTSR2 expressed in HEK293 cell membranes
ChEMBL 987 30 14 11 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.5b01495
CHEMBL3785364 145978 0 None -4 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]NT(8 to 13 residues) from human NTSR2 expressed in HEK293 cell membranesDisplacement of [3H]NT(8 to 13 residues) from human NTSR2 expressed in HEK293 cell membranes
ChEMBL 987 30 14 11 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.5b01495
CHEMBL3786291 145978 0 None -4 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]NT(8 to 13 residues) from human NTSR2 expressed in HEK293 cell membranesDisplacement of [3H]NT(8 to 13 residues) from human NTSR2 expressed in HEK293 cell membranes
ChEMBL 987 30 14 11 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.5b01495
CHEMBL3787706 145978 0 None -4 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]NT(8 to 13 residues) from human NTSR2 expressed in HEK293 cell membranesDisplacement of [3H]NT(8 to 13 residues) from human NTSR2 expressed in HEK293 cell membranes
ChEMBL 987 30 14 11 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.5b01495
CHEMBL4579623 145978 0 None -4 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]NT(8 to 13 residues) from human NTSR2 expressed in HEK293 cell membranesDisplacement of [3H]NT(8 to 13 residues) from human NTSR2 expressed in HEK293 cell membranes
ChEMBL 987 30 14 11 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.5b01495
162668357 189252 0 None -1 2 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 1614 47 22 20 -3.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.0c01726
CHEMBL4786574 189252 0 None -1 2 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 1614 47 22 20 -3.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.0c01726
162644976 186228 0 None 1318 2 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter methodDisplacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter method
ChEMBL 787 20 8 10 1.2 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@@H]1Cc2cc(O)ccc2CN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)C[C@@H](N)CCCCN)C(C)(C)C)C(=O)O 10.1021/acs.jmedchem.0c01376
CHEMBL4740539 186228 0 None 1318 2 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter methodDisplacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter method
ChEMBL 787 20 8 10 1.2 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@@H]1Cc2cc(O)ccc2CN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)C[C@@H](N)CCCCN)C(C)(C)C)C(=O)O 10.1021/acs.jmedchem.0c01376
CHEMBL1766942 215653 0 None 131 2 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]NT from human NTS2 receptor expressed in HEK293 cellsDisplacement of [3H]NT from human NTS2 receptor expressed in HEK293 cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)CN(CCc1ccccc1)C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm200006c
162662194 188236 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 813 18 10 11 -0.6 CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H]1CCCN1C(=O)[C@@H]1C/C=C\C[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1)C(=O)O 10.1021/acs.jmedchem.0c01726
CHEMBL4764437 188236 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 813 18 10 11 -0.6 CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H]1CCCN1C(=O)[C@@H]1C/C=C\C[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1)C(=O)O 10.1021/acs.jmedchem.0c01726
101873359 120835 25 None - 1 Rat 6.7 pKi = 6.7 Binding
Displacement of [125I]neurotensin from rat NTS2 receptor expressed in CHO-K1 cells by competitive binding assayDisplacement of [125I]neurotensin from rat NTS2 receptor expressed in CHO-K1 cells by competitive binding assay
ChEMBL 553 10 3 6 4.1 Cc1ccc(S(=O)(=O)Nc2ccc3c(c2)c(C(=O)C(F)(F)F)cn3CC(=O)N[C@@H](CC(C)C)C(=O)O)cc1 10.1021/jm500857r
CHEMBL3326831 120835 25 None - 1 Rat 6.7 pKi = 6.7 Binding
Displacement of [125I]neurotensin from rat NTS2 receptor expressed in CHO-K1 cells by competitive binding assayDisplacement of [125I]neurotensin from rat NTS2 receptor expressed in CHO-K1 cells by competitive binding assay
ChEMBL 553 10 3 6 4.1 Cc1ccc(S(=O)(=O)Nc2ccc3c(c2)c(C(=O)C(F)(F)F)cn3CC(=O)N[C@@H](CC(C)C)C(=O)O)cc1 10.1021/jm500857r
134136231 149253 0 None 10 2 Human 5.7 pKi = 5.7 Binding
Displacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation countingDisplacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation counting
ChEMBL 751 19 7 9 1.4 CC(C)C[C@H](NC(=O)C1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)CCOC1c1ccc(Br)cc1)C(=O)O 10.1016/j.bmc.2016.10.039
CHEMBL3890335 149253 0 None 10 2 Human 5.7 pKi = 5.7 Binding
Displacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation countingDisplacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation counting
ChEMBL 751 19 7 9 1.4 CC(C)C[C@H](NC(=O)C1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)CCOC1c1ccc(Br)cc1)C(=O)O 10.1016/j.bmc.2016.10.039
1574 9585 20 None -107 6 Rat 7.7 pKi = 7.7 Binding
Displacement of [125L]NT from rat neurotensin receptor type 2 expressed in CHOK1 cells by radioligand binding assayDisplacement of [125L]NT from rat neurotensin receptor type 2 expressed in CHOK1 cells by radioligand binding assay
ChEMBL None None None None 10.1016/j.bmcl.2014.11.047
1579 9585 20 None -107 6 Rat 7.7 pKi = 7.7 Binding
Displacement of [125L]NT from rat neurotensin receptor type 2 expressed in CHOK1 cells by radioligand binding assayDisplacement of [125L]NT from rat neurotensin receptor type 2 expressed in CHOK1 cells by radioligand binding assay
ChEMBL None None None None 10.1016/j.bmcl.2014.11.047
25077406 9585 20 None -107 6 Rat 7.7 pKi = 7.7 Binding
Displacement of [125L]NT from rat neurotensin receptor type 2 expressed in CHOK1 cells by radioligand binding assayDisplacement of [125L]NT from rat neurotensin receptor type 2 expressed in CHOK1 cells by radioligand binding assay
ChEMBL None None None None 10.1016/j.bmcl.2014.11.047
3830 9585 20 None -107 6 Rat 7.7 pKi = 7.7 Binding
Displacement of [125L]NT from rat neurotensin receptor type 2 expressed in CHOK1 cells by radioligand binding assayDisplacement of [125L]NT from rat neurotensin receptor type 2 expressed in CHOK1 cells by radioligand binding assay
ChEMBL None None None None 10.1016/j.bmcl.2014.11.047
CHEMBL407196 9585 20 None -107 6 Rat 7.7 pKi = 7.7 Binding
Displacement of [125L]NT from rat neurotensin receptor type 2 expressed in CHOK1 cells by radioligand binding assayDisplacement of [125L]NT from rat neurotensin receptor type 2 expressed in CHOK1 cells by radioligand binding assay
ChEMBL None None None None 10.1016/j.bmcl.2014.11.047
CHEMBL411195 219648 0 None -1 2 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]NT from human NTS2 receptor expressed in HEK293 cellsDisplacement of [3H]NT from human NTS2 receptor expressed in HEK293 cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)CN(CCCCN)C(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm200006c
44447826 103730 0 None -4 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]NT from human NTS2 receptor expressed in HEK293 cellsDisplacement of [3H]NT from human NTS2 receptor expressed in HEK293 cells
ChEMBL 831 25 13 10 -0.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)C[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm200006c
CHEMBL266230 103730 0 None -4 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]NT from human NTS2 receptor expressed in HEK293 cellsDisplacement of [3H]NT from human NTS2 receptor expressed in HEK293 cells
ChEMBL 831 25 13 10 -0.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)C[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm200006c
162652765 187209 0 None - 1 Human 5.7 pKi = 5.7 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 716 17 10 10 -0.6 CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H]1C/C=C\C[C@@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1)C(=O)O 10.1021/acs.jmedchem.0c01726
CHEMBL4752398 187209 0 None - 1 Human 5.7 pKi = 5.7 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 716 17 10 10 -0.6 CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H]1C/C=C\C[C@@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1)C(=O)O 10.1021/acs.jmedchem.0c01726
134140868 153518 0 None 56 2 Human 6.6 pKi = 6.6 Binding
Displacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation countingDisplacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation counting
ChEMBL 864 23 8 10 2.0 CC[C@H](C)[C@H](NC(=O)[C@]1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)CCO[C@@H]1c1ccc(Br)cc1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/j.bmc.2016.10.039
CHEMBL3924268 153518 0 None 56 2 Human 6.6 pKi = 6.6 Binding
Displacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation countingDisplacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation counting
ChEMBL 864 23 8 10 2.0 CC[C@H](C)[C@H](NC(=O)[C@]1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)CCO[C@@H]1c1ccc(Br)cc1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/j.bmc.2016.10.039
162667305 189341 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity to NTS2 (unknown origin)Binding affinity to NTS2 (unknown origin)
ChEMBL 812 13 8 9 3.0 CC[C@H](C)[C@H](NC(=O)[C@@H]1Cc2ccc(O)c(c2)C/C=C/CCCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.0c01726
CHEMBL4787727 189341 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity to NTS2 (unknown origin)Binding affinity to NTS2 (unknown origin)
ChEMBL 812 13 8 9 3.0 CC[C@H](C)[C@H](NC(=O)[C@@H]1Cc2ccc(O)c(c2)C/C=C/CCCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.0c01726
162677287 190258 0 None 3 2 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter methodDisplacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter method
ChEMBL 816 22 13 10 -1.1 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1cccc(O)c1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(C)(C)C)C(=O)O 10.1021/acs.jmedchem.0c01376
CHEMBL4799352 190258 0 None 3 2 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter methodDisplacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter method
ChEMBL 816 22 13 10 -1.1 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1cccc(O)c1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(C)(C)C)C(=O)O 10.1021/acs.jmedchem.0c01376
CHEMBL1766924 215640 0 None -2 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]NT from human NTS2 receptor expressed in HEK293 cellsDisplacement of [3H]NT from human NTS2 receptor expressed in HEK293 cells
ChEMBL None None None None 10.1021/jm200006c
54583075 68067 0 None -3 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]NT from human NTS2 receptor expressed in HEK293 cellsDisplacement of [3H]NT from human NTS2 receptor expressed in HEK293 cells
ChEMBL 831 25 13 10 -0.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@H](CC(=O)O)CC(C)C 10.1021/jm200006c
CHEMBL1766939 68067 0 None -3 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]NT from human NTS2 receptor expressed in HEK293 cellsDisplacement of [3H]NT from human NTS2 receptor expressed in HEK293 cells
ChEMBL 831 25 13 10 -0.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@H](CC(=O)O)CC(C)C 10.1021/jm200006c
162658073 187784 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 813 17 10 11 -0.6 CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H]1C/C=C\C[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)O 10.1021/acs.jmedchem.0c01726
CHEMBL4758998 187784 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 813 17 10 11 -0.6 CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H]1C/C=C\C[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)O 10.1021/acs.jmedchem.0c01726
137646112 164698 0 None 21 2 Human 6.6 pKi = 6.6 Binding
Displacement of 125I-[Tyr3]-NT from human NTS2 receptor expressed in human 1321N1 cell membranes after 30 mins by gamma counting analysisDisplacement of 125I-[Tyr3]-NT from human NTS2 receptor expressed in human 1321N1 cell membranes after 30 mins by gamma counting analysis
ChEMBL 726 26 9 10 -0.2 CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.6b01848
CHEMBL4084378 164698 0 None 21 2 Human 6.6 pKi = 6.6 Binding
Displacement of 125I-[Tyr3]-NT from human NTS2 receptor expressed in human 1321N1 cell membranes after 30 mins by gamma counting analysisDisplacement of 125I-[Tyr3]-NT from human NTS2 receptor expressed in human 1321N1 cell membranes after 30 mins by gamma counting analysis
ChEMBL 726 26 9 10 -0.2 CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.6b01848
90644393 118923 0 None - 1 Rat 5.6 pKi = 5.6 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
ChEMBL 483 7 2 5 5.5 COc1ccccc1-c1cc(C(=O)N[C@H](C(=O)O)C2CCCCC2)nn1-c1cccc2ccccc12 10.1021/jm5003843
CHEMBL3290100 118923 0 None - 1 Rat 5.6 pKi = 5.6 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
ChEMBL 483 7 2 5 5.5 COc1ccccc1-c1cc(C(=O)N[C@H](C(=O)O)C2CCCCC2)nn1-c1cccc2ccccc12 10.1021/jm5003843
134136231 149253 0 None 10 2 Human 4.6 pKi = 4.6 Binding
Displacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation countingDisplacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation counting
ChEMBL 751 19 7 9 1.4 CC(C)C[C@H](NC(=O)C1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)CCOC1c1ccc(Br)cc1)C(=O)O 10.1016/j.bmc.2016.10.039
CHEMBL3890335 149253 0 None 10 2 Human 4.6 pKi = 4.6 Binding
Displacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation countingDisplacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation counting
ChEMBL 751 19 7 9 1.4 CC(C)C[C@H](NC(=O)C1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)CCOC1c1ccc(Br)cc1)C(=O)O 10.1016/j.bmc.2016.10.039
118729840 124723 0 None - 1 Rat 6.6 pKi = 6.6 Binding
Displacement of [I125]neurotensin from rat NTS2 overexpressed in CHO-k1 cells by competitive binding AssayDisplacement of [I125]neurotensin from rat NTS2 overexpressed in CHO-k1 cells by competitive binding Assay
ChEMBL 467 7 2 6 4.7 COc1cccc(OC)c1-c1cc(NC(=O)C2(C(=O)O)CCCCC2)nn1-c1ccc(F)cc1 10.1016/j.bmcl.2015.03.083
CHEMBL3403507 124723 0 None - 1 Rat 6.6 pKi = 6.6 Binding
Displacement of [I125]neurotensin from rat NTS2 overexpressed in CHO-k1 cells by competitive binding AssayDisplacement of [I125]neurotensin from rat NTS2 overexpressed in CHO-k1 cells by competitive binding Assay
ChEMBL 467 7 2 6 4.7 COc1cccc(OC)c1-c1cc(NC(=O)C2(C(=O)O)CCCCC2)nn1-c1ccc(F)cc1 10.1016/j.bmcl.2015.03.083
1574 9585 20 None -107 6 Rat 7.6 pKi = 7.6 Binding
Displacement of [125I]neurotensin from rat NTS2 receptor expressed in CHO-K1 cells by competitive binding assayDisplacement of [125I]neurotensin from rat NTS2 receptor expressed in CHO-K1 cells by competitive binding assay
ChEMBL None None None None 10.1021/jm500857r
1579 9585 20 None -107 6 Rat 7.6 pKi = 7.6 Binding
Displacement of [125I]neurotensin from rat NTS2 receptor expressed in CHO-K1 cells by competitive binding assayDisplacement of [125I]neurotensin from rat NTS2 receptor expressed in CHO-K1 cells by competitive binding assay
ChEMBL None None None None 10.1021/jm500857r
25077406 9585 20 None -107 6 Rat 7.6 pKi = 7.6 Binding
Displacement of [125I]neurotensin from rat NTS2 receptor expressed in CHO-K1 cells by competitive binding assayDisplacement of [125I]neurotensin from rat NTS2 receptor expressed in CHO-K1 cells by competitive binding assay
ChEMBL None None None None 10.1021/jm500857r
3830 9585 20 None -107 6 Rat 7.6 pKi = 7.6 Binding
Displacement of [125I]neurotensin from rat NTS2 receptor expressed in CHO-K1 cells by competitive binding assayDisplacement of [125I]neurotensin from rat NTS2 receptor expressed in CHO-K1 cells by competitive binding assay
ChEMBL None None None None 10.1021/jm500857r
CHEMBL407196 9585 20 None -107 6 Rat 7.6 pKi = 7.6 Binding
Displacement of [125I]neurotensin from rat NTS2 receptor expressed in CHO-K1 cells by competitive binding assayDisplacement of [125I]neurotensin from rat NTS2 receptor expressed in CHO-K1 cells by competitive binding assay
ChEMBL None None None None 10.1021/jm500857r
134138287 154615 0 None 3 2 Human 4.6 pKi = 4.6 Binding
Displacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation countingDisplacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation counting
ChEMBL 779 19 9 9 0.6 CC(C)C[C@H](NC(=O)C1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCCN)CCOC1c1ccc(Br)cc1)C(=O)O 10.1016/j.bmc.2016.10.039
CHEMBL3932989 154615 0 None 3 2 Human 4.6 pKi = 4.6 Binding
Displacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation countingDisplacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation counting
ChEMBL 779 19 9 9 0.6 CC(C)C[C@H](NC(=O)C1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCCN)CCOC1c1ccc(Br)cc1)C(=O)O 10.1016/j.bmc.2016.10.039
134153118 159379 0 None 1202 2 Human 7.5 pKi = 7.5 Binding
Displacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation countingDisplacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation counting
ChEMBL 802 21 13 11 -2.2 CC(C)C[C@H](NC(=O)CNC(=O)[C@@]1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)CCO[C@H]1c1ccc(O)cc1)C(=O)O 10.1016/j.bmc.2016.10.039
CHEMBL3971946 159379 0 None 1202 2 Human 7.5 pKi = 7.5 Binding
Displacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation countingDisplacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation counting
ChEMBL 802 21 13 11 -2.2 CC(C)C[C@H](NC(=O)CNC(=O)[C@@]1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)CCO[C@H]1c1ccc(O)cc1)C(=O)O 10.1016/j.bmc.2016.10.039
162660385 187983 0 None -7 5 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter methodDisplacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter method
ChEMBL 1358 40 14 15 3.0 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C 10.1021/acs.jmedchem.0c01376
CHEMBL4761165 187983 0 None -7 5 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter methodDisplacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter method
ChEMBL 1358 40 14 15 3.0 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C 10.1021/acs.jmedchem.0c01376
162659782 188100 0 None 4 2 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter methodDisplacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter method
ChEMBL 845 22 13 10 -0.5 Cc1cc(O)cc(C)c1C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C 10.1021/acs.jmedchem.0c01376
CHEMBL4762684 188100 0 None 4 2 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter methodDisplacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter method
ChEMBL 845 22 13 10 -0.5 Cc1cc(O)cc(C)c1C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C 10.1021/acs.jmedchem.0c01376
155569717 183018 0 None 1 2 Human 8.5 pKi = 8.5 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 2 in HEK293 cells homogenate incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 2 in HEK293 cells homogenate incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1657 48 16 20 4.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCOCCOCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL4537266 183018 0 None 1 2 Human 8.5 pKi = 8.5 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 2 in HEK293 cells homogenate incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 2 in HEK293 cells homogenate incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1657 48 16 20 4.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCOCCOCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL4594723 183018 0 None 1 2 Human 8.5 pKi = 8.5 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 2 in HEK293 cells homogenate incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 2 in HEK293 cells homogenate incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1657 48 16 20 4.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCOCCOCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
155569737 183414 0 None -1 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 2 in HEK293 cells homogenate incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 2 in HEK293 cells homogenate incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1597 44 16 18 5.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL4457798 183414 0 None -1 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 2 in HEK293 cells homogenate incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 2 in HEK293 cells homogenate incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1597 44 16 18 5.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL4597941 183414 0 None -1 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 2 in HEK293 cells homogenate incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 2 in HEK293 cells homogenate incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1597 44 16 18 5.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
146159772 9091 33 None -2 3 Rat 7.5 pKi = 7.5 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
ChEMBL 420 4 1 3 4.9 N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F 10.1021/jm5003843
1564 9091 33 None -2 3 Rat 7.5 pKi = 7.5 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
ChEMBL 420 4 1 3 4.9 N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F 10.1021/jm5003843
1586 9091 33 None -2 3 Rat 7.5 pKi = 7.5 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
ChEMBL 420 4 1 3 4.9 N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F 10.1021/jm5003843
54385 9091 33 None -2 3 Rat 7.5 pKi = 7.5 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
ChEMBL 420 4 1 3 4.9 N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F 10.1021/jm5003843
CHEMBL1615438 9091 33 None -2 3 Rat 7.5 pKi = 7.5 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
ChEMBL 420 4 1 3 4.9 N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F 10.1021/jm5003843
DB01106 9091 33 None -2 3 Rat 7.5 pKi = 7.5 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
ChEMBL 420 4 1 3 4.9 N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F 10.1021/jm5003843
CHEMBL342252 218452 0 None -338 4 Rat 7.5 pKi = 7.5 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm5003843
CHEMBL2369509 216409 0 None 5 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]NT from human NTS2 receptor expressed in HEK293 cellsDisplacement of [3H]NT from human NTS2 receptor expressed in HEK293 cells
ChEMBL None None None CC[C@H](C)N(CC(=O)N[C@@H](CC(C)C)C(=O)O)C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN 10.1021/jm200006c
54580109 68068 0 None 251 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]NT from human NTS2 receptor expressed in HEK293 cellsDisplacement of [3H]NT from human NTS2 receptor expressed in HEK293 cells
ChEMBL 862 24 11 8 3.0 C=C(N[C@@H](CC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)CCCNC(=N)N 10.1021/jm200006c
CHEMBL1766947 68068 0 None 251 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]NT from human NTS2 receptor expressed in HEK293 cellsDisplacement of [3H]NT from human NTS2 receptor expressed in HEK293 cells
ChEMBL 862 24 11 8 3.0 C=C(N[C@@H](CC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)CCCNC(=N)N 10.1021/jm200006c
162646717 186387 0 None 1 2 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 1671 50 23 21 -4.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(N)=O 10.1021/acs.jmedchem.0c01726
CHEMBL4742361 186387 0 None 1 2 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 1671 50 23 21 -4.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(N)=O 10.1021/acs.jmedchem.0c01726
CHEMBL1766934 215650 1 None -2 2 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]NT from human NTS2 receptor expressed in HEK293 cellsDisplacement of [3H]NT from human NTS2 receptor expressed in HEK293 cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@H](CC(C)C)C(=O)O 10.1021/jm200006c
CHEMBL1766941 215652 0 None 1230 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]NT from human NTS2 receptor expressed in HEK293 cellsDisplacement of [3H]NT from human NTS2 receptor expressed in HEK293 cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)CN(CCc1ccc(OC)cc1)C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm200006c
162667051 189302 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 703 20 12 9 -1.6 CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)O 10.1021/acs.jmedchem.0c01726
CHEMBL4787163 189302 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 703 20 12 9 -1.6 CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)O 10.1021/acs.jmedchem.0c01726
1574 9585 20 None -15 6 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL None None None None 10.1021/acs.jmedchem.0c01726
1579 9585 20 None -15 6 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL None None None None 10.1021/acs.jmedchem.0c01726
25077406 9585 20 None -15 6 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL None None None None 10.1021/acs.jmedchem.0c01726
3830 9585 20 None -15 6 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL None None None None 10.1021/acs.jmedchem.0c01726
CHEMBL407196 9585 20 None -15 6 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL None None None None 10.1021/acs.jmedchem.0c01726
168274909 197028 0 None 2 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]NT(8-13) from human NTSR2 expressed in HEK293 cell membranes by radioligand displacement assayDisplacement of [3H]NT(8-13) from human NTSR2 expressed in HEK293 cell membranes by radioligand displacement assay
ChEMBL 995 31 15 14 -1.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSCCN)C(=O)O 10.1016/j.bmc.2022.116720
CHEMBL5175252 197028 0 None 2 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]NT(8-13) from human NTSR2 expressed in HEK293 cell membranes by radioligand displacement assayDisplacement of [3H]NT(8-13) from human NTSR2 expressed in HEK293 cell membranes by radioligand displacement assay
ChEMBL 995 31 15 14 -1.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSCCN)C(=O)O 10.1016/j.bmc.2022.116720
CHEMBL1766946 215657 0 None 7413 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]NT from human NTS2 receptor expressed in HEK293 cellsDisplacement of [3H]NT from human NTS2 receptor expressed in HEK293 cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)CN(CCc1ccc(O)cc1)C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm200006c
CHEMBL1766945 215656 0 None 1905 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]NT from human NTS2 receptor expressed in HEK293 cellsDisplacement of [3H]NT from human NTS2 receptor expressed in HEK293 cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)CN(CCc1ccc(O)cc1)C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm200006c
162668803 189514 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity to NTS2 (unknown origin)Binding affinity to NTS2 (unknown origin)
ChEMBL 799 13 9 10 1.0 CC[C@H](C)[C@H](NC(=O)[C@@H]1Cc2ccc(O)c(c2)C/C=C/CNCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.0c01726
CHEMBL4789911 189514 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity to NTS2 (unknown origin)Binding affinity to NTS2 (unknown origin)
ChEMBL 799 13 9 10 1.0 CC[C@H](C)[C@H](NC(=O)[C@@H]1Cc2ccc(O)c(c2)C/C=C/CNCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.0c01726
162655533 187560 0 None -1 2 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 1646 51 24 21 -3.9 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.0c01726
CHEMBL4756326 187560 0 None -1 2 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 1646 51 24 21 -3.9 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.0c01726
1574 9585 20 None -15 6 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]NT from human NTS2 receptor expressed in HEK293 cellsDisplacement of [3H]NT from human NTS2 receptor expressed in HEK293 cells
ChEMBL None None None None 10.1021/jm200006c
1579 9585 20 None -15 6 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]NT from human NTS2 receptor expressed in HEK293 cellsDisplacement of [3H]NT from human NTS2 receptor expressed in HEK293 cells
ChEMBL None None None None 10.1021/jm200006c
25077406 9585 20 None -15 6 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]NT from human NTS2 receptor expressed in HEK293 cellsDisplacement of [3H]NT from human NTS2 receptor expressed in HEK293 cells
ChEMBL None None None None 10.1021/jm200006c
3830 9585 20 None -15 6 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]NT from human NTS2 receptor expressed in HEK293 cellsDisplacement of [3H]NT from human NTS2 receptor expressed in HEK293 cells
ChEMBL None None None None 10.1021/jm200006c
CHEMBL407196 9585 20 None -15 6 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]NT from human NTS2 receptor expressed in HEK293 cellsDisplacement of [3H]NT from human NTS2 receptor expressed in HEK293 cells
ChEMBL None None None None 10.1021/jm200006c
1574 9585 20 None -15 6 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]NT(8 to 13) from human NTS2 receptor expressed in HEK293 cellsDisplacement of [3H]NT(8 to 13) from human NTS2 receptor expressed in HEK293 cells
ChEMBL None None None None 10.1021/jm401491e
1579 9585 20 None -15 6 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]NT(8 to 13) from human NTS2 receptor expressed in HEK293 cellsDisplacement of [3H]NT(8 to 13) from human NTS2 receptor expressed in HEK293 cells
ChEMBL None None None None 10.1021/jm401491e
25077406 9585 20 None -15 6 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]NT(8 to 13) from human NTS2 receptor expressed in HEK293 cellsDisplacement of [3H]NT(8 to 13) from human NTS2 receptor expressed in HEK293 cells
ChEMBL None None None None 10.1021/jm401491e
3830 9585 20 None -15 6 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]NT(8 to 13) from human NTS2 receptor expressed in HEK293 cellsDisplacement of [3H]NT(8 to 13) from human NTS2 receptor expressed in HEK293 cells
ChEMBL None None None None 10.1021/jm401491e
CHEMBL407196 9585 20 None -15 6 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]NT(8 to 13) from human NTS2 receptor expressed in HEK293 cellsDisplacement of [3H]NT(8 to 13) from human NTS2 receptor expressed in HEK293 cells
ChEMBL None None None None 10.1021/jm401491e
119192 9259 54 None -114 9 Human 6.4 pKi = 6.4 Binding
Binding affinity to NTR2 (unknown origin)Binding affinity to NTR2 (unknown origin)
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1016/j.bmc.2013.04.075
1582 9259 54 None -114 9 Human 6.4 pKi = 6.4 Binding
Binding affinity to NTR2 (unknown origin)Binding affinity to NTR2 (unknown origin)
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1016/j.bmc.2013.04.075
CHEMBL506981 9259 54 None -114 9 Human 6.4 pKi = 6.4 Binding
Binding affinity to NTR2 (unknown origin)Binding affinity to NTR2 (unknown origin)
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1016/j.bmc.2013.04.075
DB06455 9259 54 None -114 9 Human 6.4 pKi = 6.4 Binding
Binding affinity to NTR2 (unknown origin)Binding affinity to NTR2 (unknown origin)
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1016/j.bmc.2013.04.075
137651580 163885 0 None - 1 Human 5.4 pKi = 5.4 Binding
Displacement of 125I-[Tyr3]-NT from human NTS2 receptor expressed in human 1321N1 cell membranes after 30 mins by gamma counting analysisDisplacement of 125I-[Tyr3]-NT from human NTS2 receptor expressed in human 1321N1 cell membranes after 30 mins by gamma counting analysis
ChEMBL 712 24 9 10 -0.8 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.6b01848
CHEMBL4074624 163885 0 None - 1 Human 5.4 pKi = 5.4 Binding
Displacement of 125I-[Tyr3]-NT from human NTS2 receptor expressed in human 1321N1 cell membranes after 30 mins by gamma counting analysisDisplacement of 125I-[Tyr3]-NT from human NTS2 receptor expressed in human 1321N1 cell membranes after 30 mins by gamma counting analysis
ChEMBL 712 24 9 10 -0.8 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.6b01848
54585023 68065 0 None -5 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]NT from human NTS2 receptor expressed in HEK293 cellsDisplacement of [3H]NT from human NTS2 receptor expressed in HEK293 cells
ChEMBL 831 25 13 10 -0.7 CC[C@H](C)[C@H](NC(=O)C[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm200006c
CHEMBL1766937 68065 0 None -5 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]NT from human NTS2 receptor expressed in HEK293 cellsDisplacement of [3H]NT from human NTS2 receptor expressed in HEK293 cells
ChEMBL 831 25 13 10 -0.7 CC[C@H](C)[C@H](NC(=O)C[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm200006c
118721826 122865 0 None - 1 Rat 6.3 pKi = 6.3 Binding
Displacement of [125L]NT from rat neurotensin receptor type 2 expressed in CHOK1 cells by radioligand binding assayDisplacement of [125L]NT from rat neurotensin receptor type 2 expressed in CHOK1 cells by radioligand binding assay
ChEMBL 483 7 2 6 4.7 COc1cccc(OC)c1-c1nc(C(=O)N[C@H](C(=O)O)C2CCCCC2)nc2ccc(Cl)cc12 10.1016/j.bmcl.2014.11.047
CHEMBL3356855 122865 0 None - 1 Rat 6.3 pKi = 6.3 Binding
Displacement of [125L]NT from rat neurotensin receptor type 2 expressed in CHOK1 cells by radioligand binding assayDisplacement of [125L]NT from rat neurotensin receptor type 2 expressed in CHOK1 cells by radioligand binding assay
ChEMBL 483 7 2 6 4.7 COc1cccc(OC)c1-c1nc(C(=O)N[C@H](C(=O)O)C2CCCCC2)nc2ccc(Cl)cc12 10.1016/j.bmcl.2014.11.047
137651867 164027 0 None -1 2 Human 6.3 pKi = 6.3 Binding
Displacement of 125I-[Tyr3]-NT from human NTS2 receptor expressed in human 1321N1 cell membranes after 30 mins by gamma counting analysisDisplacement of 125I-[Tyr3]-NT from human NTS2 receptor expressed in human 1321N1 cell membranes after 30 mins by gamma counting analysis
ChEMBL 734 24 9 10 -0.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.6b01848
CHEMBL4076517 164027 0 None -1 2 Human 6.3 pKi = 6.3 Binding
Displacement of 125I-[Tyr3]-NT from human NTS2 receptor expressed in human 1321N1 cell membranes after 30 mins by gamma counting analysisDisplacement of 125I-[Tyr3]-NT from human NTS2 receptor expressed in human 1321N1 cell membranes after 30 mins by gamma counting analysis
ChEMBL 734 24 9 10 -0.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.6b01848
134143837 157330 0 None 9 2 Human 4.3 pKi = 4.3 Binding
Displacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation countingDisplacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation counting
ChEMBL 807 19 11 9 -0.3 CC(C)C[C@H](NC(=O)C1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)CCOC1c1ccc(Br)cc1)C(=O)O 10.1016/j.bmc.2016.10.039
CHEMBL3954824 157330 0 None 9 2 Human 4.3 pKi = 4.3 Binding
Displacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation countingDisplacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation counting
ChEMBL 807 19 11 9 -0.3 CC(C)C[C@H](NC(=O)C1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)CCOC1c1ccc(Br)cc1)C(=O)O 10.1016/j.bmc.2016.10.039
168283408 197670 0 None 3 2 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]NT(8-13) from human NTSR2 expressed in HEK293 cell membranes by radioligand displacement assayDisplacement of [3H]NT(8-13) from human NTSR2 expressed in HEK293 cell membranes by radioligand displacement assay
ChEMBL 1009 32 15 14 -0.9 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCSSCCN)C(=O)O 10.1016/j.bmc.2022.116720
CHEMBL5184967 197670 0 None 3 2 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]NT(8-13) from human NTSR2 expressed in HEK293 cell membranes by radioligand displacement assayDisplacement of [3H]NT(8-13) from human NTSR2 expressed in HEK293 cell membranes by radioligand displacement assay
ChEMBL 1009 32 15 14 -0.9 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCSSCCN)C(=O)O 10.1016/j.bmc.2022.116720
54585990 68066 0 None 46 2 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]NT from human NTS2 receptor expressed in HEK293 cellsDisplacement of [3H]NT from human NTS2 receptor expressed in HEK293 cells
ChEMBL 831 25 13 10 -0.7 CC[C@H](C)[C@H](CC(=O)N[C@@H](CC(C)C)C(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N 10.1021/jm200006c
CHEMBL1766938 68066 0 None 46 2 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]NT from human NTS2 receptor expressed in HEK293 cellsDisplacement of [3H]NT from human NTS2 receptor expressed in HEK293 cells
ChEMBL 831 25 13 10 -0.7 CC[C@H](C)[C@H](CC(=O)N[C@@H](CC(C)C)C(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N 10.1021/jm200006c
CHEMBL1766929 215645 1 None -8 2 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]NT from human NTS2 receptor expressed in HEK293 cellsDisplacement of [3H]NT from human NTS2 receptor expressed in HEK293 cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm200006c
1580 10437 46 None -6 4 Rat 8.2 pKi = 8.2 Binding
Displacement of [125I]neurotensin from rat NTS2 receptor expressed in CHO-K1 cells by competitive binding assayDisplacement of [125I]neurotensin from rat NTS2 receptor expressed in CHO-K1 cells by competitive binding assay
ChEMBL 685 13 2 8 5.7 COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1021/jm500857r
5311451 10437 46 None -6 4 Rat 8.2 pKi = 8.2 Binding
Displacement of [125I]neurotensin from rat NTS2 receptor expressed in CHO-K1 cells by competitive binding assayDisplacement of [125I]neurotensin from rat NTS2 receptor expressed in CHO-K1 cells by competitive binding assay
ChEMBL 685 13 2 8 5.7 COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1021/jm500857r
CHEMBL3040381 10437 46 None -6 4 Rat 8.2 pKi = 8.2 Binding
Displacement of [125I]neurotensin from rat NTS2 receptor expressed in CHO-K1 cells by competitive binding assayDisplacement of [125I]neurotensin from rat NTS2 receptor expressed in CHO-K1 cells by competitive binding assay
ChEMBL 685 13 2 8 5.7 COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1021/jm500857r
162669302 189441 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 716 17 10 10 -0.6 CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1C/C=C\C[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1)C(=O)O 10.1021/acs.jmedchem.0c01726
CHEMBL4788991 189441 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 716 17 10 10 -0.6 CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1C/C=C\C[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1)C(=O)O 10.1021/acs.jmedchem.0c01726
134134595 150398 0 None 34 2 Human 6.3 pKi = 6.3 Binding
Displacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation countingDisplacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation counting
ChEMBL 808 21 8 10 0.6 CC(C)C[C@H](NC(=O)CNC(=O)C1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)CCOC1c1ccc(Br)cc1)C(=O)O 10.1016/j.bmc.2016.10.039
CHEMBL3899699 150398 0 None 34 2 Human 6.3 pKi = 6.3 Binding
Displacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation countingDisplacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation counting
ChEMBL 808 21 8 10 0.6 CC(C)C[C@H](NC(=O)CNC(=O)C1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)CCOC1c1ccc(Br)cc1)C(=O)O 10.1016/j.bmc.2016.10.039
CHEMBL1766930 215646 0 None 1 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]NT from human NTS2 receptor expressed in HEK293 cellsDisplacement of [3H]NT from human NTS2 receptor expressed in HEK293 cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm200006c
90644391 118921 0 None - 1 Rat 6.3 pKi = 6.3 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
ChEMBL 504 6 2 6 5.3 COc1ccccc1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1ccnc2cc(Cl)ccc12 10.1021/jm5003843
CHEMBL3290098 118921 0 None - 1 Rat 6.3 pKi = 6.3 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
ChEMBL 504 6 2 6 5.3 COc1ccccc1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1ccnc2cc(Cl)ccc12 10.1021/jm5003843
90644392 118922 0 None - 1 Rat 6.3 pKi = 6.3 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
ChEMBL 513 8 2 6 5.5 COc1cccc(OC)c1-c1cc(C(=O)N[C@H](C(=O)O)C2CCCCC2)nn1-c1cccc2ccccc12 10.1021/jm5003843
CHEMBL3290099 118922 0 None - 1 Rat 6.3 pKi = 6.3 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
ChEMBL 513 8 2 6 5.5 COc1cccc(OC)c1-c1cc(C(=O)N[C@H](C(=O)O)C2CCCCC2)nn1-c1cccc2ccccc12 10.1021/jm5003843
168291832 198641 0 None -1 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]NT(8-13) from human NTSR2 expressed in HEK293 cell membranes by radioligand displacement assayDisplacement of [3H]NT(8-13) from human NTSR2 expressed in HEK293 cell membranes by radioligand displacement assay
ChEMBL 881 27 14 13 -1.8 CC(C)C[C@H](NC(=O)[C@H](CSSCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)O 10.1016/j.bmc.2022.116720
CHEMBL5199274 198641 0 None -1 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]NT(8-13) from human NTSR2 expressed in HEK293 cell membranes by radioligand displacement assayDisplacement of [3H]NT(8-13) from human NTSR2 expressed in HEK293 cell membranes by radioligand displacement assay
ChEMBL 881 27 14 13 -1.8 CC(C)C[C@H](NC(=O)[C@H](CSSCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)O 10.1016/j.bmc.2022.116720
CHEMBL1766923 215639 0 None -12 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]NT from human NTS2 receptor expressed in HEK293 cellsDisplacement of [3H]NT from human NTS2 receptor expressed in HEK293 cells
ChEMBL None None None None 10.1021/jm200006c
CHEMBL408057 219475 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.0c01726
CHEMBL1766931 215647 0 None -2 2 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]NT from human NTS2 receptor expressed in HEK293 cellsDisplacement of [3H]NT from human NTS2 receptor expressed in HEK293 cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm200006c
1580 10437 46 None -6 4 Rat 8.2 pKi = 8.2 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
ChEMBL 685 13 2 8 5.7 COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1021/jm5003843
5311451 10437 46 None -6 4 Rat 8.2 pKi = 8.2 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
ChEMBL 685 13 2 8 5.7 COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1021/jm5003843
CHEMBL3040381 10437 46 None -6 4 Rat 8.2 pKi = 8.2 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
ChEMBL 685 13 2 8 5.7 COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1021/jm5003843
CHEMBL258221 217295 17 None -2 2 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]NT from human NTS2 receptor expressed in HEK293 cellsDisplacement of [3H]NT from human NTS2 receptor expressed in HEK293 cells
ChEMBL None None None None 10.1021/jm200006c
1569 8907 32 None -2 2 Human 8.2 pKi = 8.2 Binding
Displacement of 125I-[Tyr3]-NT from human NTS2 receptor expressed in human 1321N1 cell membranes after 30 mins by gamma counting analysisDisplacement of 125I-[Tyr3]-NT from human NTS2 receptor expressed in human 1321N1 cell membranes after 30 mins by gamma counting analysis
ChEMBL None None None None 10.1021/acs.jmedchem.6b01848
5311318 8907 32 None -2 2 Human 8.2 pKi = 8.2 Binding
Displacement of 125I-[Tyr3]-NT from human NTS2 receptor expressed in human 1321N1 cell membranes after 30 mins by gamma counting analysisDisplacement of 125I-[Tyr3]-NT from human NTS2 receptor expressed in human 1321N1 cell membranes after 30 mins by gamma counting analysis
ChEMBL None None None None 10.1021/acs.jmedchem.6b01848
CHEMBL415788 8907 32 None -2 2 Human 8.2 pKi = 8.2 Binding
Displacement of 125I-[Tyr3]-NT from human NTS2 receptor expressed in human 1321N1 cell membranes after 30 mins by gamma counting analysisDisplacement of 125I-[Tyr3]-NT from human NTS2 receptor expressed in human 1321N1 cell membranes after 30 mins by gamma counting analysis
ChEMBL None None None None 10.1021/acs.jmedchem.6b01848
CHEMBL1766944 215655 0 None 11748 2 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]NT from human NTS2 receptor expressed in HEK293 cellsDisplacement of [3H]NT from human NTS2 receptor expressed in HEK293 cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)CN(CCc1ccc(O)cc1)C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm200006c
162651256 187113 0 None -2 2 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 1630 48 23 21 -4.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.0c01726
CHEMBL4751221 187113 0 None -2 2 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 1630 48 23 21 -4.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.0c01726
134146201 155722 0 None 7 2 Human 5.2 pKi = 5.2 Binding
Displacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation countingDisplacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation counting
ChEMBL 779 19 9 9 0.6 CC(C)C[C@H](NC(=O)C1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCNC(=N)N)CCOC1c1ccc(Br)cc1)C(=O)O 10.1016/j.bmc.2016.10.039
CHEMBL3941970 155722 0 None 7 2 Human 5.2 pKi = 5.2 Binding
Displacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation countingDisplacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation counting
ChEMBL 779 19 9 9 0.6 CC(C)C[C@H](NC(=O)C1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCNC(=N)N)CCOC1c1ccc(Br)cc1)C(=O)O 10.1016/j.bmc.2016.10.039
90644383 118913 0 None - 1 Rat 6.2 pKi = 6.2 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
ChEMBL 548 8 2 7 5.5 COc1ccc(OC)c(-c2cc(C(=O)N[C@H](C(=O)O)C3CCCCC3)nn2-c2ccnc3cc(Cl)ccc23)c1 10.1021/jm5003843
CHEMBL3290090 118913 0 None - 1 Rat 6.2 pKi = 6.2 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
ChEMBL 548 8 2 7 5.5 COc1ccc(OC)c(-c2cc(C(=O)N[C@H](C(=O)O)C3CCCCC3)nn2-c2ccnc3cc(Cl)ccc23)c1 10.1021/jm5003843
134145567 155897 0 None 16 2 Human 6.2 pKi = 6.2 Binding
Displacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation countingDisplacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation counting
ChEMBL 920 23 12 10 0.2 CC[C@H](C)[C@H](NC(=O)[C@]1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)CCO[C@@H]1c1ccc(Br)cc1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/j.bmc.2016.10.039
CHEMBL3943248 155897 0 None 16 2 Human 6.2 pKi = 6.2 Binding
Displacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation countingDisplacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation counting
ChEMBL 920 23 12 10 0.2 CC[C@H](C)[C@H](NC(=O)[C@]1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)CCO[C@@H]1c1ccc(Br)cc1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/j.bmc.2016.10.039
137656771 166443 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of 125I-[Tyr3]-NT from human NTS2 receptor expressed in human 1321N1 cell membranes after 30 mins by gamma counting analysisDisplacement of 125I-[Tyr3]-NT from human NTS2 receptor expressed in human 1321N1 cell membranes after 30 mins by gamma counting analysis
ChEMBL 712 25 9 10 -0.6 CC[C@H](C)[C@H](NC(=O)C(CCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.6b01848
CHEMBL4103884 166443 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of 125I-[Tyr3]-NT from human NTS2 receptor expressed in human 1321N1 cell membranes after 30 mins by gamma counting analysisDisplacement of 125I-[Tyr3]-NT from human NTS2 receptor expressed in human 1321N1 cell membranes after 30 mins by gamma counting analysis
ChEMBL 712 25 9 10 -0.6 CC[C@H](C)[C@H](NC(=O)C(CCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.6b01848
119192 9259 54 None -17 9 Rat 7.2 pKi = 7.2 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1021/jm5003843
1582 9259 54 None -17 9 Rat 7.2 pKi = 7.2 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1021/jm5003843
CHEMBL506981 9259 54 None -17 9 Rat 7.2 pKi = 7.2 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1021/jm5003843
DB06455 9259 54 None -17 9 Rat 7.2 pKi = 7.2 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1021/jm5003843
90644400 118912 0 None - 1 Rat 7.2 pKi = 7.2 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
ChEMBL 542 6 1 6 6.3 COc1cccc(OC)c1-c1cc(C(=O)NC2C3CC4CC(C3)CC2C4)nn1-c1ccnc2cc(Cl)ccc12 10.1021/jm5003843
CHEMBL3290089 118912 0 None - 1 Rat 7.2 pKi = 7.2 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
ChEMBL 542 6 1 6 6.3 COc1cccc(OC)c1-c1cc(C(=O)NC2C3CC4CC(C3)CC2C4)nn1-c1ccnc2cc(Cl)ccc12 10.1021/jm5003843
44594765 189282 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 703 20 12 9 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)O 10.1021/acs.jmedchem.0c01726
CHEMBL4786965 189282 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 703 20 12 9 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)O 10.1021/acs.jmedchem.0c01726
90644397 118927 0 None - 1 Rat 6.2 pKi = 6.2 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
ChEMBL 481 8 2 6 4.5 COc1cccc(OC)c1-c1cc(C(=O)N[C@H](C(=O)O)C2CCCCC2)nn1-c1ccc(F)cc1 10.1021/jm5003843
CHEMBL3290104 118927 0 None - 1 Rat 6.2 pKi = 6.2 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
ChEMBL 481 8 2 6 4.5 COc1cccc(OC)c1-c1cc(C(=O)N[C@H](C(=O)O)C2CCCCC2)nn1-c1ccc(F)cc1 10.1021/jm5003843
CHEMBL172313 215631 0 None -14 3 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]NT from human NTS2 receptor expressed in HEK293 cellsDisplacement of [3H]NT from human NTS2 receptor expressed in HEK293 cells
ChEMBL None None None None 10.1021/jm200006c
CHEMBL1766925 215641 0 None -2 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]NT from human NTS2 receptor expressed in HEK293 cellsDisplacement of [3H]NT from human NTS2 receptor expressed in HEK293 cells
ChEMBL None None None None 10.1021/jm200006c
118729841 124724 0 None - 1 Rat 5.2 pKi = 5.2 Binding
Displacement of [I125]neurotensin from rat NTS2 overexpressed in CHO-k1 cells by competitive binding AssayDisplacement of [I125]neurotensin from rat NTS2 overexpressed in CHO-k1 cells by competitive binding Assay
ChEMBL 437 6 2 5 4.7 COc1ccccc1-c1cc(NC(=O)C2(C(=O)O)CCCCC2)nn1-c1ccc(F)cc1 10.1016/j.bmcl.2015.03.083
CHEMBL3403508 124724 0 None - 1 Rat 5.2 pKi = 5.2 Binding
Displacement of [I125]neurotensin from rat NTS2 overexpressed in CHO-k1 cells by competitive binding AssayDisplacement of [I125]neurotensin from rat NTS2 overexpressed in CHO-k1 cells by competitive binding Assay
ChEMBL 437 6 2 5 4.7 COc1ccccc1-c1cc(NC(=O)C2(C(=O)O)CCCCC2)nn1-c1ccc(F)cc1 10.1016/j.bmcl.2015.03.083
1581 10442 10 None -12 2 Rat 6.2 pKi = 6.2 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
ChEMBL 548 8 2 7 5.5 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)N[C@@H](C1CCCCC1)C(=O)O)OC 10.1021/jm5003843
9915499 10442 10 None -12 2 Rat 6.2 pKi = 6.2 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
ChEMBL 548 8 2 7 5.5 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)N[C@@H](C1CCCCC1)C(=O)O)OC 10.1021/jm5003843
CHEMBL461604 10442 10 None -12 2 Rat 6.2 pKi = 6.2 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
ChEMBL 548 8 2 7 5.5 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)N[C@@H](C1CCCCC1)C(=O)O)OC 10.1021/jm5003843
162651757 186987 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 1630 48 23 21 -4.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](C)C(=O)O 10.1021/acs.jmedchem.0c01726
CHEMBL4749690 186987 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 1630 48 23 21 -4.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](C)C(=O)O 10.1021/acs.jmedchem.0c01726
137660279 166147 0 None 9 2 Human 7.2 pKi = 7.2 Binding
Displacement of 125I-[Tyr3]-NT from human NTS2 receptor expressed in human 1321N1 cell membranes after 30 mins by gamma counting analysisDisplacement of 125I-[Tyr3]-NT from human NTS2 receptor expressed in human 1321N1 cell membranes after 30 mins by gamma counting analysis
ChEMBL 756 26 9 10 0.1 CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@H](C[Si](C)(C)C)C(=O)O 10.1021/acs.jmedchem.6b01848
CHEMBL4100456 166147 0 None 9 2 Human 7.2 pKi = 7.2 Binding
Displacement of 125I-[Tyr3]-NT from human NTS2 receptor expressed in human 1321N1 cell membranes after 30 mins by gamma counting analysisDisplacement of 125I-[Tyr3]-NT from human NTS2 receptor expressed in human 1321N1 cell membranes after 30 mins by gamma counting analysis
ChEMBL 756 26 9 10 0.1 CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@H](C[Si](C)(C)C)C(=O)O 10.1021/acs.jmedchem.6b01848
72737612 110367 0 None -70 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]NT(8 to 13) from human NTS2 receptor expressed in HEK293 cellsDisplacement of [3H]NT(8 to 13) from human NTS2 receptor expressed in HEK293 cells
ChEMBL 958 20 5 15 4.6 COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)C3CC4CC(C3)CC2C4)nn1-c1ccc(C(=O)N(C)CCCN(C)CCCCc2cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3F)nn2)cc1C(C)C 10.1021/jm401491e
CHEMBL3086356 110367 0 None -70 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]NT(8 to 13) from human NTS2 receptor expressed in HEK293 cellsDisplacement of [3H]NT(8 to 13) from human NTS2 receptor expressed in HEK293 cells
ChEMBL 958 20 5 15 4.6 COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)C3CC4CC(C3)CC2C4)nn1-c1ccc(C(=O)N(C)CCCN(C)CCCCc2cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3F)nn2)cc1C(C)C 10.1021/jm401491e
CHEMBL3979668 219291 0 None 1 2 Human 7.2 pKi = 7.2 Binding
Displacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation countingDisplacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation counting
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(Br)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/j.bmc.2016.10.039
CHEMBL1766933 215649 0 None 18 2 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]NT from human NTS2 receptor expressed in HEK293 cellsDisplacement of [3H]NT from human NTS2 receptor expressed in HEK293 cells
ChEMBL None None None CC[C@H](C)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm200006c
90644395 118925 0 None - 1 Rat 6.2 pKi = 6.2 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
ChEMBL 469 6 2 5 5.2 COc1ccccc1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1cccc2ccccc12 10.1021/jm5003843
CHEMBL3290102 118925 0 None - 1 Rat 6.2 pKi = 6.2 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
ChEMBL 469 6 2 5 5.2 COc1ccccc1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1cccc2ccccc12 10.1021/jm5003843
1580 10437 46 None -6 4 Rat 8.2 pKi = 8.2 Binding
Displacement of [125L]NT from rat neurotensin receptor type 2 expressed in CHOK1 cells by radioligand binding assayDisplacement of [125L]NT from rat neurotensin receptor type 2 expressed in CHOK1 cells by radioligand binding assay
ChEMBL 685 13 2 8 5.7 COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1016/j.bmcl.2014.11.047
5311451 10437 46 None -6 4 Rat 8.2 pKi = 8.2 Binding
Displacement of [125L]NT from rat neurotensin receptor type 2 expressed in CHOK1 cells by radioligand binding assayDisplacement of [125L]NT from rat neurotensin receptor type 2 expressed in CHOK1 cells by radioligand binding assay
ChEMBL 685 13 2 8 5.7 COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1016/j.bmcl.2014.11.047
CHEMBL3040381 10437 46 None -6 4 Rat 8.2 pKi = 8.2 Binding
Displacement of [125L]NT from rat neurotensin receptor type 2 expressed in CHOK1 cells by radioligand binding assayDisplacement of [125L]NT from rat neurotensin receptor type 2 expressed in CHOK1 cells by radioligand binding assay
ChEMBL 685 13 2 8 5.7 COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1016/j.bmcl.2014.11.047
155569719 183151 0 None -2 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 2 in HEK293 cells homogenate incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 2 in HEK293 cells homogenate incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1577 47 15 18 5.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)NC(=O)NCCOCCOCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2ccccc21)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL4592541 183151 0 None -2 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 2 in HEK293 cells homogenate incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 2 in HEK293 cells homogenate incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1577 47 15 18 5.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)NC(=O)NCCOCCOCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2ccccc21)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL4595797 183151 0 None -2 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 2 in HEK293 cells homogenate incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 2 in HEK293 cells homogenate incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1577 47 15 18 5.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)NC(=O)NCCOCCOCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2ccccc21)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
132547200 155778 0 None 28 2 Human 6.2 pKi = 6.2 Binding
Displacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation countingDisplacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation counting
ChEMBL 802 21 13 11 -2.2 CC(C)C[C@H](NC(=O)CNC(=O)[C@]1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)CCO[C@@H]1c1ccc(O)cc1)C(=O)O 10.1016/j.bmc.2016.10.039
CHEMBL3942339 155778 0 None 28 2 Human 6.2 pKi = 6.2 Binding
Displacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation countingDisplacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation counting
ChEMBL 802 21 13 11 -2.2 CC(C)C[C@H](NC(=O)CNC(=O)[C@]1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)CCO[C@@H]1c1ccc(O)cc1)C(=O)O 10.1016/j.bmc.2016.10.039
1580 10437 46 None -70 4 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]NT(8 to 13) from human NTS2 receptor expressed in HEK293 cellsDisplacement of [3H]NT(8 to 13) from human NTS2 receptor expressed in HEK293 cells
ChEMBL 685 13 2 8 5.7 COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1021/jm401491e
5311451 10437 46 None -70 4 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]NT(8 to 13) from human NTS2 receptor expressed in HEK293 cellsDisplacement of [3H]NT(8 to 13) from human NTS2 receptor expressed in HEK293 cells
ChEMBL 685 13 2 8 5.7 COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1021/jm401491e
CHEMBL3040381 10437 46 None -70 4 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]NT(8 to 13) from human NTS2 receptor expressed in HEK293 cellsDisplacement of [3H]NT(8 to 13) from human NTS2 receptor expressed in HEK293 cells
ChEMBL 685 13 2 8 5.7 COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1021/jm401491e
162658930 187804 0 None -3 2 Human 6.1 pKi = 6.1 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 1630 48 23 21 -4.4 CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)O 10.1021/acs.jmedchem.0c01726
CHEMBL4759247 187804 0 None -3 2 Human 6.1 pKi = 6.1 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 1630 48 23 21 -4.4 CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)O 10.1021/acs.jmedchem.0c01726
162651726 187068 0 None -12 5 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter methodDisplacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter method
ChEMBL 1350 33 15 16 1.1 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N2Cc3ccc(O)cc3C[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C)C1=O 10.1021/acs.jmedchem.0c01376
CHEMBL4750783 187068 0 None -12 5 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter methodDisplacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter method
ChEMBL 1350 33 15 16 1.1 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N2Cc3ccc(O)cc3C[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C)C1=O 10.1021/acs.jmedchem.0c01376
162674795 190236 0 None -3 2 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 1580 48 22 20 -4.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.0c01726
CHEMBL4799000 190236 0 None -3 2 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 1580 48 22 20 -4.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.0c01726
162677029 190283 0 None -4 2 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 1632 50 23 21 -3.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.0c01726
CHEMBL4799695 190283 0 None -4 2 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 1632 50 23 21 -3.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.0c01726
162674076 189864 0 None -3 2 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 1629 48 22 20 -2.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.0c01726
CHEMBL4794420 189864 0 None -3 2 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 1629 48 22 20 -2.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.0c01726
CHEMBL1766825 215638 0 None 3235 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]NT from human NTS2 receptor expressed in HEK293 cellsDisplacement of [3H]NT from human NTS2 receptor expressed in HEK293 cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)CN(CCc1ccc(O)cc1)C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm200006c
CHEMBL1766926 215642 0 None 15 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]NT from human NTS2 receptor expressed in HEK293 cellsDisplacement of [3H]NT from human NTS2 receptor expressed in HEK293 cells
ChEMBL None None None None 10.1021/jm200006c
CHEMBL3950695 219261 0 None 2 2 Human 6.1 pKi = 6.1 Binding
Displacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation countingDisplacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation counting
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccc(Br)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/j.bmc.2016.10.039
118721825 122864 0 None - 1 Rat 7.1 pKi = 7.1 Binding
Displacement of [125L]NT from rat neurotensin receptor type 2 expressed in CHOK1 cells by radioligand binding assayDisplacement of [125L]NT from rat neurotensin receptor type 2 expressed in CHOK1 cells by radioligand binding assay
ChEMBL 457 8 2 6 4.2 COc1cccc(OC)c1-c1nc(C(=O)N[C@@H](CC(C)C)C(=O)O)nc2ccc(Cl)cc12 10.1016/j.bmcl.2014.11.047
CHEMBL3356854 122864 0 None - 1 Rat 7.1 pKi = 7.1 Binding
Displacement of [125L]NT from rat neurotensin receptor type 2 expressed in CHOK1 cells by radioligand binding assayDisplacement of [125L]NT from rat neurotensin receptor type 2 expressed in CHOK1 cells by radioligand binding assay
ChEMBL 457 8 2 6 4.2 COc1cccc(OC)c1-c1nc(C(=O)N[C@@H](CC(C)C)C(=O)O)nc2ccc(Cl)cc12 10.1016/j.bmcl.2014.11.047
162667468 189335 0 None -1 2 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 1615 46 22 20 -3.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.0c01726
CHEMBL4787611 189335 0 None -1 2 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 1615 46 22 20 -3.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.0c01726
162676199 190046 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 718 17 10 10 -0.4 CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1)C(=O)O 10.1021/acs.jmedchem.0c01726
CHEMBL4796587 190046 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 718 17 10 10 -0.4 CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1)C(=O)O 10.1021/acs.jmedchem.0c01726
162653994 187327 0 None -1 2 Human 7.0 pKi = 7.0 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 1587 46 20 20 -2.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.0c01726
CHEMBL4753810 187327 0 None -1 2 Human 7.0 pKi = 7.0 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 1587 46 20 20 -2.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.0c01726
118721824 122863 0 None - 1 Rat 6.0 pKi = 6.0 Binding
Displacement of [125L]NT from rat neurotensin receptor type 2 expressed in CHOK1 cells by radioligand binding assayDisplacement of [125L]NT from rat neurotensin receptor type 2 expressed in CHOK1 cells by radioligand binding assay
ChEMBL 469 6 2 6 4.5 COc1cccc(OC)c1-c1nc(C(=O)NC2(C(=O)O)CCCCC2)nc2ccc(Cl)cc12 10.1016/j.bmcl.2014.11.047
CHEMBL3356853 122863 0 None - 1 Rat 6.0 pKi = 6.0 Binding
Displacement of [125L]NT from rat neurotensin receptor type 2 expressed in CHOK1 cells by radioligand binding assayDisplacement of [125L]NT from rat neurotensin receptor type 2 expressed in CHOK1 cells by radioligand binding assay
ChEMBL 469 6 2 6 4.5 COc1cccc(OC)c1-c1nc(C(=O)NC2(C(=O)O)CCCCC2)nc2ccc(Cl)cc12 10.1016/j.bmcl.2014.11.047
1569 8907 32 None -2 2 Human 7.0 pKd None 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11723247
5311318 8907 32 None -2 2 Human 7.0 pKd None 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11723247
CHEMBL415788 8907 32 None -2 2 Human 7.0 pKd None 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11723247
1574 9585 20 None -19 6 Mouse 8.6 pKd None 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8795617
1574 9585 20 None -19 6 Mouse 8.6 pKd None 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9480852
1579 9585 20 None -19 6 Mouse 8.6 pKd None 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8795617
1579 9585 20 None -19 6 Mouse 8.6 pKd None 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9480852
25077406 9585 20 None -19 6 Mouse 8.6 pKd None 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8795617
25077406 9585 20 None -19 6 Mouse 8.6 pKd None 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9480852
3830 9585 20 None -19 6 Mouse 8.6 pKd None 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8795617
3830 9585 20 None -19 6 Mouse 8.6 pKd None 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9480852
CHEMBL407196 9585 20 None -19 6 Mouse 8.6 pKd None 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8795617
CHEMBL407196 9585 20 None -19 6 Mouse 8.6 pKd None 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9480852
None 223145 0 125I-Neurotensin 588 2 Mouse 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 420 4 1 3 4.9 CC1CN(CCC1(C2=CC=CC=C2)C(=O)O)C3CCC(CC3)(C#N)C4=CC=C(C=C4)F None
146159772 9091 33 None -4 3 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 420 4 1 3 4.9 N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F None
1564 9091 33 None -4 3 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 420 4 1 3 4.9 N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F None
1586 9091 33 None -4 3 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 420 4 1 3 4.9 N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F None
54385 9091 33 None -4 3 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 420 4 1 3 4.9 N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F None
CHEMBL1615438 9091 33 None -4 3 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 420 4 1 3 4.9 N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F None
DB01106 9091 33 None -4 3 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 420 4 1 3 4.9 N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F None
1574 9585 20 125I-Neurotensin -19 6 Mouse 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase None None None None None
1579 9585 20 125I-Neurotensin -19 6 Mouse 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase None None None None None
25077406 9585 20 125I-Neurotensin -19 6 Mouse 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase None None None None None
3830 9585 20 125I-Neurotensin -19 6 Mouse 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase None None None None None
CHEMBL407196 9585 20 125I-Neurotensin -19 6 Mouse 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase None None None None None
146159772 9091 33 None -2 3 Rat 8.1 pKi = 8.1 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
Drug Central 420 4 1 3 4.9 N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F None
1564 9091 33 None -2 3 Rat 8.1 pKi = 8.1 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
Drug Central 420 4 1 3 4.9 N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F None
1586 9091 33 None -2 3 Rat 8.1 pKi = 8.1 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
Drug Central 420 4 1 3 4.9 N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F None
54385 9091 33 None -2 3 Rat 8.1 pKi = 8.1 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
Drug Central 420 4 1 3 4.9 N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F None
CHEMBL1615438 9091 33 None -2 3 Rat 8.1 pKi = 8.1 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
Drug Central 420 4 1 3 4.9 N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F None
DB01106 9091 33 None -2 3 Rat 8.1 pKi = 8.1 Binding
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingDisplacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting
Drug Central 420 4 1 3 4.9 N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F None
146159772 9091 33 None -4 3 Human 6.8 pKi = 6.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 420 4 1 3 4.9 N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F 11723247
146159772 9091 33 None -4 3 Human 6.8 pKi = 6.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 420 4 1 3 4.9 N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F 8795617
1564 9091 33 None -4 3 Human 6.8 pKi = 6.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 420 4 1 3 4.9 N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F 11723247
1564 9091 33 None -4 3 Human 6.8 pKi = 6.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 420 4 1 3 4.9 N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F 8795617
1586 9091 33 None -4 3 Human 6.8 pKi = 6.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 420 4 1 3 4.9 N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F 11723247
1586 9091 33 None -4 3 Human 6.8 pKi = 6.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 420 4 1 3 4.9 N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F 8795617
54385 9091 33 None -4 3 Human 6.8 pKi = 6.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 420 4 1 3 4.9 N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F 11723247
54385 9091 33 None -4 3 Human 6.8 pKi = 6.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 420 4 1 3 4.9 N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F 8795617
CHEMBL1615438 9091 33 None -4 3 Human 6.8 pKi = 6.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 420 4 1 3 4.9 N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F 11723247
CHEMBL1615438 9091 33 None -4 3 Human 6.8 pKi = 6.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 420 4 1 3 4.9 N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F 8795617
DB01106 9091 33 None -4 3 Human 6.8 pKi = 6.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 420 4 1 3 4.9 N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F 11723247
DB01106 9091 33 None -4 3 Human 6.8 pKi = 6.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 420 4 1 3 4.9 N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F 8795617
119192 9259 54 None -114 9 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 11723247
1582 9259 54 None -114 9 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 11723247
CHEMBL506981 9259 54 None -114 9 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 11723247
DB06455 9259 54 None -114 9 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 11723247
1571 8909 0 None 10 2 Human 6.8 pKi None 6.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11723247
1568 8904 0 None 31 2 Human 7.2 pKi None 7.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11723247
1572 8910 0 None -1 2 Human 8.7 pKi None 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11723247
5311320 8910 0 None -1 2 Human 8.7 pKi None 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11723247
1574 9585 20 None -15 6 Human 8.8 pKi None 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11723247
1579 9585 20 None -15 6 Human 8.8 pKi None 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11723247
25077406 9585 20 None -15 6 Human 8.8 pKi None 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11723247
3830 9585 20 None -15 6 Human 8.8 pKi None 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11723247
CHEMBL407196 9585 20 None -15 6 Human 8.8 pKi None 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11723247