Ligand source activities (1 row/activity)



Get vendors


Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
Sel. page Common
name		 GPCRdb
ID		 #Vendors

 Reference
ligand		 Fold
selectivity		 # Tested
GPCRs		 Species

 p-value
(-log)		 Activity
Type		 Activity
Relation		 Activity
Value		 AssayType

 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

 H acc

 LogP

 Smiles

 DOI
118037818 141487 0 None 1 2 Human 5.5 pAC50 = 5.5 Functional
Agonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assayAgonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assay
ChEMBL 428 4 2 4 4.9 O=C(Nc1ccccc1C(=O)Nc1cccc(C(F)(F)F)c1)c1ccc2c(c1)OCO2 nan
CHEMBL3718470 141487 0 None 1 2 Human 5.5 pAC50 = 5.5 Functional
Agonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assayAgonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assay
ChEMBL 428 4 2 4 4.9 O=C(Nc1ccccc1C(=O)Nc1cccc(C(F)(F)F)c1)c1ccc2c(c1)OCO2 nan
90010773 140689 0 None 1 2 Human 5.1 pAC50 = 5.1 Functional
Agonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assayAgonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assay
ChEMBL 375 4 2 4 4.2 O=C(Nc1ccccc1C(=O)Nc1cccc(C(F)(F)F)c1)c1ccno1 nan
CHEMBL3715750 140689 0 None 1 2 Human 5.1 pAC50 = 5.1 Functional
Agonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assayAgonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assay
ChEMBL 375 4 2 4 4.2 O=C(Nc1ccccc1C(=O)Nc1cccc(C(F)(F)F)c1)c1ccno1 nan
127024071 140803 0 None - 1 Human 5.0 pAC50 = 5.0 Functional
Agonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assayAgonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assay
ChEMBL 361 4 3 2 4.9 O=C(Nc1ccc2cc[nH]c2c1)c1ccccc1NC(=O)C1CCCCC1 nan
CHEMBL3716158 140803 0 None - 1 Human 5.0 pAC50 = 5.0 Functional
Agonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assayAgonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assay
ChEMBL 361 4 3 2 4.9 O=C(Nc1ccc2cc[nH]c2c1)c1ccccc1NC(=O)C1CCCCC1 nan
12503 7911 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Determined in a HTRF cAMP assay using HEK-RXFP2 cells.Determined in a HTRF cAMP assay using HEK-RXFP2 cells.
Guide to Pharmacology 787 5 1 5 6.6 FC(F)(F)OC1=CC(I)=C(OCC(=O)N2CCN3[C@@H](C2)C(=O)NC4=C(C=C(C=C4)C5=CC(=CC(=C5)C(F)(F)F)C(F)(F)F)C3=O)C=C1 36333465
167993647 7911 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Determined in a HTRF cAMP assay using HEK-RXFP2 cells.Determined in a HTRF cAMP assay using HEK-RXFP2 cells.
Guide to Pharmacology 787 5 1 5 6.6 FC(F)(F)OC1=CC(I)=C(OCC(=O)N2CCN3[C@@H](C2)C(=O)NC4=C(C=C(C=C4)C5=CC(=CC(=C5)C(F)(F)F)C(F)(F)F)C3=O)C=C1 36333465
11914 8826 0 None - 1 Human 10.0 pEC50 = 10 Functional
Receptor activationReceptor activation
Guide to Pharmacology None None None None 22654853
8346 6990 0 None -165 2 Human 6.0 pEC50 = 6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21878627
1989 10076 0 None -17 3 Human 9.1 pEC50 = 9.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 18434306


Get vendors


Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
Sel. page Similar-
ity		 Common
name		 GPCRdb
ID		 #Vendors

 Reference
ligand		 Fold
selectivity		 # Tested
GPCRs		 Species

 p-value
(-log)		 Activity
Type		 Activity
Relation		 Activity
Value		 Assay
Type		 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

 H acc

 LogP

 Smiles

 DOI
11913 9508 0 None - 1 Human 8.7 pKd = 8.7 Binding
Receptor binding affinityReceptor binding affinity
Guide to Pharmacology None None None None 24056075
1995 8825 0 None 16982 2 Human 10.4 pKd = 10.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 18434306
3875 8380 0 None - 1 Human 9.0 pKd = 9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 18529069
11914 8826 0 None - 1 Human 7.8 pKi = 7.8 Binding
Receptor bindingReceptor binding
Guide to Pharmacology None None None None 22654853
3885 8827 0 None - 1 Human 5.1 pKi = 5.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 16547350
8346 6990 0 None -9 2 Human 6.0 pKi = 6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21878627
8333 8062 0 None - 1 Human 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 17120268
8332 7070 0 None - 1 Human 8.3 pKi = 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 20570702
1989 10076 0 None -40 3 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15649866
1989 10076 0 None -40 3 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 18434306
155817469 8828 0 None - 1 Human 8.5 pKi = 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 20560146
4372 8828 0 None - 1 Human 8.5 pKi = 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 20560146
8331 7021 0 None - 1 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 20570702
155817501 6978 0 None - 1 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 18434306
8330 6978 0 None - 1 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 18434306
134813893 7002 0 None - 1 Human 9.1 pKi = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 18434306
8329 7002 0 None - 1 Human 9.1 pKi = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 18434306
1995 8825 0 None 16982 2 Human 9.5 pKi = 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15649866
1995 8825 0 None 16982 2 Human 9.5 pKi = 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 18434306
1990 10081 0 None -81 4 Human 7.0 pKi None 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 16411781
1994 10075 0 None -39 2 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15649866
1992 10078 0 None -15 2 Human 7.9 pKi None 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15649866
1988 10079 0 None - 1 Human 8.8 pKi None 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 16411781