Ligand source activities (1 row/activity)



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Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
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name		 GPCRdb
ID		 #Vendors

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ligand		 Fold
selectivity		 # Tested
GPCRs		 Species

 p-value
(-log)		 Activity
Type		 Activity
Relation		 Activity
Value		 AssayType

 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

 H acc

 LogP

 Smiles

 DOI
15931130 108758 0 None 1000 2 Rat 9.4 pEC50 = 9.4 Functional
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL 737 21 6 8 1.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
CHEMBL301477 108758 0 None 1000 2 Rat 9.4 pEC50 = 9.4 Functional
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL 737 21 6 8 1.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
44297866 108821 0 None 38 2 Rat 9.4 pEC50 = 9.4 Functional
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL 723 21 6 8 1.0 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1CCC(NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCN)C1=O)C(N)=O 10.1021/jm00169a003
CHEMBL301841 108821 0 None 38 2 Rat 9.4 pEC50 = 9.4 Functional
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL 723 21 6 8 1.0 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1CCC(NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCN)C1=O)C(N)=O 10.1021/jm00169a003
2089 9542 28 None -3 8 Rat 9.3 pEC50 = 9.3 Functional
Allosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as increase in intracellular calcium level by spectrofluorimetryAllosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as increase in intracellular calcium level by spectrofluorimetry
ChEMBL None None None None 10.1021/jm900671k
3795 9542 28 None -3 8 Rat 9.3 pEC50 = 9.3 Functional
Allosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as increase in intracellular calcium level by spectrofluorimetryAllosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as increase in intracellular calcium level by spectrofluorimetry
ChEMBL None None None None 10.1021/jm900671k
5311311 9542 28 None -3 8 Rat 9.3 pEC50 = 9.3 Functional
Allosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as increase in intracellular calcium level by spectrofluorimetryAllosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as increase in intracellular calcium level by spectrofluorimetry
ChEMBL None None None None 10.1021/jm900671k
CHEMBL217406 9542 28 None -3 8 Rat 9.3 pEC50 = 9.3 Functional
Allosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as increase in intracellular calcium level by spectrofluorimetryAllosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as increase in intracellular calcium level by spectrofluorimetry
ChEMBL None None None None 10.1021/jm900671k
2098 10466 36 None -63 11 Rat 9.0 pEC50 = 9 Functional
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL None None None None 10.1021/jm00169a003
36511 10466 36 None -63 11 Rat 9.0 pEC50 = 9 Functional
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL None None None None 10.1021/jm00169a003
3805 10466 36 None -63 11 Rat 9.0 pEC50 = 9 Functional
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL None None None None 10.1021/jm00169a003
3835 10466 36 None -63 11 Rat 9.0 pEC50 = 9 Functional
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL None None None None 10.1021/jm00169a003
CHEMBL235363 10466 36 None -63 11 Rat 9.0 pEC50 = 9 Functional
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL None None None None 10.1021/jm00169a003
44355179 31120 0 None 33 2 Rat 8.9 pEC50 = 8.9 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 962 30 11 13 -2.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(C)=O)C(C)C)C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL134091 31120 0 None 33 2 Rat 8.9 pEC50 = 8.9 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 962 30 11 13 -2.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(C)=O)C(C)C)C1=O)C(N)=O 10.1021/jm00100a027
2089 9542 28 None -3 8 Rat 8.8 pEC50 = 8.8 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL None None None None 10.1021/jm00100a027
3795 9542 28 None -3 8 Rat 8.8 pEC50 = 8.8 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL None None None None 10.1021/jm00100a027
5311311 9542 28 None -3 8 Rat 8.8 pEC50 = 8.8 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL None None None None 10.1021/jm00100a027
CHEMBL217406 9542 28 None -3 8 Rat 8.8 pEC50 = 8.8 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL None None None None 10.1021/jm00100a027
73356363 96279 0 None -9 2 Rat 8.0 pEC50 = 8.0 Functional
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL 711 22 7 8 0.9 CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
CHEMBL2372949 96279 0 None -9 2 Rat 8.0 pEC50 = 8.0 Functional
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL 711 22 7 8 0.9 CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
10055612 103200 0 None -31 3 Rat 5.9 pEC50 = 5.9 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 711 23 7 8 0.9 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O 10.1021/jm00100a027
CHEMBL262049 103200 0 None -31 3 Rat 5.9 pEC50 = 5.9 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 711 23 7 8 0.9 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O 10.1021/jm00100a027
10327810 123514 0 None 31 2 Rat 5.9 pEC50 = 5.9 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1C[C@@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@@H]2C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL337465 123514 0 None 31 2 Rat 5.9 pEC50 = 5.9 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1C[C@@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@@H]2C1=O)C(N)=O 10.1021/jm00100a027
10259515 163916 0 None -954 2 Rat 4.9 pEC50 = 4.9 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 751 22 6 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O 10.1021/jm00100a027
CHEMBL407511 163916 0 None -954 2 Rat 4.9 pEC50 = 4.9 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 751 22 6 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O 10.1021/jm00100a027
44355678 30261 0 None -4 2 Rat 5.9 pEC50 = 5.9 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 777 21 5 8 2.3 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC[C@]2(CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCCN)C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL133362 30261 0 None -4 2 Rat 5.9 pEC50 = 5.9 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 777 21 5 8 2.3 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC[C@]2(CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCCN)C1=O)C(N)=O 10.1021/jm00100a027
10462850 31035 0 None 36 2 Rat 7.8 pEC50 = 7.8 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1C[C@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@H]2C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL134012 31035 0 None 36 2 Rat 7.8 pEC50 = 7.8 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1C[C@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@H]2C1=O)C(N)=O 10.1021/jm00100a027
2098 10466 36 None -63 11 Rat 6.8 pEC50 = 6.8 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL None None None None 10.1021/jm00100a027
36511 10466 36 None -63 11 Rat 6.8 pEC50 = 6.8 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL None None None None 10.1021/jm00100a027
3805 10466 36 None -63 11 Rat 6.8 pEC50 = 6.8 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL None None None None 10.1021/jm00100a027
3835 10466 36 None -63 11 Rat 6.8 pEC50 = 6.8 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL None None None None 10.1021/jm00100a027
CHEMBL235363 10466 36 None -63 11 Rat 6.8 pEC50 = 6.8 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL None None None None 10.1021/jm00100a027
2098 10466 36 None -63 11 Rat 6.8 pEC50 = 6.8 Functional
Agonist activity was measured at neurokinin-2 receptor in the rat colon muscularis mucosaeAgonist activity was measured at neurokinin-2 receptor in the rat colon muscularis mucosae
ChEMBL None None None None 10.1021/jm00169a003
36511 10466 36 None -63 11 Rat 6.8 pEC50 = 6.8 Functional
Agonist activity was measured at neurokinin-2 receptor in the rat colon muscularis mucosaeAgonist activity was measured at neurokinin-2 receptor in the rat colon muscularis mucosae
ChEMBL None None None None 10.1021/jm00169a003
3805 10466 36 None -63 11 Rat 6.8 pEC50 = 6.8 Functional
Agonist activity was measured at neurokinin-2 receptor in the rat colon muscularis mucosaeAgonist activity was measured at neurokinin-2 receptor in the rat colon muscularis mucosae
ChEMBL None None None None 10.1021/jm00169a003
3835 10466 36 None -63 11 Rat 6.8 pEC50 = 6.8 Functional
Agonist activity was measured at neurokinin-2 receptor in the rat colon muscularis mucosaeAgonist activity was measured at neurokinin-2 receptor in the rat colon muscularis mucosae
ChEMBL None None None None 10.1021/jm00169a003
CHEMBL235363 10466 36 None -63 11 Rat 6.8 pEC50 = 6.8 Functional
Agonist activity was measured at neurokinin-2 receptor in the rat colon muscularis mucosaeAgonist activity was measured at neurokinin-2 receptor in the rat colon muscularis mucosae
ChEMBL None None None None 10.1021/jm00169a003
73348740 96281 0 None -51 2 Rat 6.7 pEC50 = 6.7 Functional
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL 737 21 6 8 1.4 CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
CHEMBL2372953 96281 0 None -51 2 Rat 6.7 pEC50 = 6.7 Functional
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL 737 21 6 8 1.4 CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
44297675 107396 0 None 47 2 Rat 8.6 pEC50 = 8.6 Functional
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL 711 22 7 8 0.9 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
CHEMBL291903 107396 0 None 47 2 Rat 8.6 pEC50 = 8.6 Functional
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL 711 22 7 8 0.9 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
10395375 123435 0 None 2 2 Rat 5.7 pEC50 = 5.7 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1C[C@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@H]2C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL337037 123435 0 None 2 2 Rat 5.7 pEC50 = 5.7 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1C[C@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@H]2C1=O)C(N)=O 10.1021/jm00100a027
2090 9543 25 None -6 9 Rat 7.6 pEC50 = 7.6 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL None None None None 10.1021/jm00100a027
5311312 9543 25 None -6 9 Rat 7.6 pEC50 = 7.6 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL None None None None 10.1021/jm00100a027
CHEMBL437797 9543 25 None -6 9 Rat 7.6 pEC50 = 7.6 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL None None None None 10.1021/jm00100a027
CHEMBL335054 218259 0 None 20 3 Rat 8.5 pEC50 = 8.5 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(C)C)C(N)=O 10.1021/jm00100a027
5311135 28495 12 None 316 3 Rat 8.4 pEC50 = 8.4 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 920 29 11 13 -2.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(C)C)C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL131872 28495 12 None 316 3 Rat 8.4 pEC50 = 8.4 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 920 29 11 13 -2.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(C)C)C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL134481 215508 0 None 1 3 Rat 7.5 pEC50 = 7.5 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(N)=O 10.1021/jm00100a027
44355648 103899 0 None 22 3 Rat 7.4 pEC50 = 7.4 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 994 29 10 13 -1.5 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C2C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL267712 103899 0 None 22 3 Rat 7.4 pEC50 = 7.4 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 994 29 10 13 -1.5 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C2C1=O)C(N)=O 10.1021/jm00100a027
10350201 123939 0 None 6 2 Rat 6.3 pEC50 = 6.3 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1C[C@@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@@H]2C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL339391 123939 0 None 6 2 Rat 6.3 pEC50 = 6.3 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1C[C@@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@@H]2C1=O)C(N)=O 10.1021/jm00100a027
44355117 28560 0 None 19 3 Rat 7.2 pEC50 = 7.2 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 946 28 10 13 -2.1 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC2CCN(C(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(C)C)C2C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL131923 28560 0 None 19 3 Rat 7.2 pEC50 = 7.2 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 946 28 10 13 -2.1 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC2CCN(C(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(C)C)C2C1=O)C(N)=O 10.1021/jm00100a027
44297786 108486 0 None - 1 Rat 7.2 pEC50 = 7.2 Functional
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL 723 21 6 8 1.0 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCN)C1=O)C(N)=O 10.1021/jm00169a003
CHEMBL299503 108486 0 None - 1 Rat 7.2 pEC50 = 7.2 Functional
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL 723 21 6 8 1.0 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCN)C1=O)C(N)=O 10.1021/jm00169a003
44355368 32413 0 None 1 3 Rat 7.2 pEC50 = 7.2 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 737 22 6 8 1.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCCN)C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL135186 32413 0 None 1 3 Rat 7.2 pEC50 = 7.2 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 737 22 6 8 1.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCCN)C1=O)C(N)=O 10.1021/jm00100a027
2089 9542 28 None -3 8 Rat 7.2 pEC50 = 7.2 Functional
Allosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as cAMP production by radioimmunoassayAllosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as cAMP production by radioimmunoassay
ChEMBL None None None None 10.1021/jm900671k
3795 9542 28 None -3 8 Rat 7.2 pEC50 = 7.2 Functional
Allosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as cAMP production by radioimmunoassayAllosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as cAMP production by radioimmunoassay
ChEMBL None None None None 10.1021/jm900671k
5311311 9542 28 None -3 8 Rat 7.2 pEC50 = 7.2 Functional
Allosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as cAMP production by radioimmunoassayAllosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as cAMP production by radioimmunoassay
ChEMBL None None None None 10.1021/jm900671k
CHEMBL217406 9542 28 None -3 8 Rat 7.2 pEC50 = 7.2 Functional
Allosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as cAMP production by radioimmunoassayAllosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as cAMP production by radioimmunoassay
ChEMBL None None None None 10.1021/jm900671k
15931129 201757 0 None -1 2 Rat 8.2 pEC50 = 8.2 Functional
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL 697 22 7 8 0.6 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
CHEMBL54622 201757 0 None -1 2 Rat 8.2 pEC50 = 8.2 Functional
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL 697 22 7 8 0.6 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
44297852 105783 0 None 7 2 Rat 8.1 pEC50 = 8.1 Functional
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL 763 20 5 8 1.9 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1CCC2(CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCN)C1=O)C(N)=O 10.1021/jm00169a003
CHEMBL280020 105783 0 None 7 2 Rat 8.1 pEC50 = 8.1 Functional
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL 763 20 5 8 1.9 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1CCC2(CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCN)C1=O)C(N)=O 10.1021/jm00169a003
11765601 103199 0 None 9 2 Rat 7.0 pEC50 = 7.0 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 751 22 6 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O 10.1021/jm00100a027
CHEMBL262048 103199 0 None 9 2 Rat 7.0 pEC50 = 7.0 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 751 22 6 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O 10.1021/jm00100a027
10009596 122287 0 None -1 2 Rat 7.0 pEC50 = 7.0 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 663 22 7 8 0.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(C)C)C(N)=O 10.1021/jm00100a027
CHEMBL335248 122287 0 None -1 2 Rat 7.0 pEC50 = 7.0 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 663 22 7 8 0.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(C)C)C(N)=O 10.1021/jm00100a027
145953024 169369 0 None -4 5 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence methodAntagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence method
ChEMBL 886 20 2 10 3.4 CC[C@H](C)[C@@H](OC(=O)/C=C/c1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)OC 10.1021/acs.jmedchem.8b00885
CHEMBL4168948 169369 0 None -4 5 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence methodAntagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence method
ChEMBL 886 20 2 10 3.4 CC[C@H](C)[C@@H](OC(=O)/C=C/c1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)OC 10.1021/acs.jmedchem.8b00885
145952624 169164 0 None -1 4 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence methodAntagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence method
ChEMBL 889 21 2 10 3.3 CC[C@H](C)[C@@H](OC(=O)CCc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)OC 10.1021/acs.jmedchem.8b00885
CHEMBL4165525 169164 0 None -1 4 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence methodAntagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence method
ChEMBL 889 21 2 10 3.3 CC[C@H](C)[C@@H](OC(=O)CCc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)OC 10.1021/acs.jmedchem.8b00885
10917690 214384 1 None -645 4 Human 5.5 pIC50 = 5.5 Functional
Compound was evaluated for the antagonistic activity against Tachykinin receptor 2Compound was evaluated for the antagonistic activity against Tachykinin receptor 2
ChEMBL 471 8 0 5 5.4 COc1ccc(CCN2CCC(C(=O)c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 10.1016/S0960-894X(97)10097-X
CHEMBL95051 214384 1 None -645 4 Human 5.5 pIC50 = 5.5 Functional
Compound was evaluated for the antagonistic activity against Tachykinin receptor 2Compound was evaluated for the antagonistic activity against Tachykinin receptor 2
ChEMBL 471 8 0 5 5.4 COc1ccc(CCN2CCC(C(=O)c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 10.1016/S0960-894X(97)10097-X
145957924 168872 0 None -1 4 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence methodAntagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence method
ChEMBL 886 20 2 10 3.4 CC[C@H](C)[C@@H](OC(=O)/C=C\c1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)OC 10.1021/acs.jmedchem.8b00885
CHEMBL4161021 168872 0 None -1 4 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence methodAntagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence method
ChEMBL 886 20 2 10 3.4 CC[C@H](C)[C@@H](OC(=O)/C=C\c1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)OC 10.1021/acs.jmedchem.8b00885
CHEMBL412740 219800 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Tested for the binding affinity to human NK2 receptor expressed in Sf-9 insect larval cells using 0.1 nM 2-[125 I] iodohistidyl neurokinin ATested for the binding affinity to human NK2 receptor expressed in Sf-9 insect larval cells using 0.1 nM 2-[125 I] iodohistidyl neurokinin A
ChEMBL None None None CC(C)C[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc1ccc(/N=C(\S)Cc2ccccc2)cc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCS)C(N)=O 10.1016/S0960-894X(97)00088-7
145958767 169034 0 None 1 3 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence methodAntagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence method
ChEMBL 932 22 2 11 2.8 CC[C@H](C)[C@@H](OC(=O)[C@H](Cc1ccccc1)N(C)C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)OC 10.1021/acs.jmedchem.8b00885
CHEMBL4163618 169034 0 None 1 3 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence methodAntagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence method
ChEMBL 932 22 2 11 2.8 CC[C@H](C)[C@@H](OC(=O)[C@H](Cc1ccccc1)N(C)C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)OC 10.1021/acs.jmedchem.8b00885
2089 9542 28 None -3 8 Human 8.1 pIC50 = 8.1 Functional
Tested for the binding affinity to human NK2 receptor expressed in Sf-9 insect larval cells using 0.1 nM 2-[125 I] iodohistidyl neurokinin ATested for the binding affinity to human NK2 receptor expressed in Sf-9 insect larval cells using 0.1 nM 2-[125 I] iodohistidyl neurokinin A
ChEMBL None None None None 10.1016/S0960-894X(97)00088-7
3795 9542 28 None -3 8 Human 8.1 pIC50 = 8.1 Functional
Tested for the binding affinity to human NK2 receptor expressed in Sf-9 insect larval cells using 0.1 nM 2-[125 I] iodohistidyl neurokinin ATested for the binding affinity to human NK2 receptor expressed in Sf-9 insect larval cells using 0.1 nM 2-[125 I] iodohistidyl neurokinin A
ChEMBL None None None None 10.1016/S0960-894X(97)00088-7
5311311 9542 28 None -3 8 Human 8.1 pIC50 = 8.1 Functional
Tested for the binding affinity to human NK2 receptor expressed in Sf-9 insect larval cells using 0.1 nM 2-[125 I] iodohistidyl neurokinin ATested for the binding affinity to human NK2 receptor expressed in Sf-9 insect larval cells using 0.1 nM 2-[125 I] iodohistidyl neurokinin A
ChEMBL None None None None 10.1016/S0960-894X(97)00088-7
CHEMBL217406 9542 28 None -3 8 Human 8.1 pIC50 = 8.1 Functional
Tested for the binding affinity to human NK2 receptor expressed in Sf-9 insect larval cells using 0.1 nM 2-[125 I] iodohistidyl neurokinin ATested for the binding affinity to human NK2 receptor expressed in Sf-9 insect larval cells using 0.1 nM 2-[125 I] iodohistidyl neurokinin A
ChEMBL None None None None 10.1016/S0960-894X(97)00088-7
CHEMBL264972 217412 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Tested for the binding affinity to human NK2 receptor expressed in Sf-9 insect larval cells using 0.1 nM 2-[125 I] iodohistidyl neurokinin ATested for the binding affinity to human NK2 receptor expressed in Sf-9 insect larval cells using 0.1 nM 2-[125 I] iodohistidyl neurokinin A
ChEMBL None None None CC(C)C[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc1ccc(NC(=S)c2ccccc2)cc1)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCS)C(N)=O 10.1016/S0960-894X(97)00088-7
153996 119445 2 None -2 6 Human 8.1 pIC50 = 8.1 Functional
Compound was evaluated for the antagonistic activity against Tachykinin receptor 2Compound was evaluated for the antagonistic activity against Tachykinin receptor 2
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL330366 119445 2 None -2 6 Human 8.1 pIC50 = 8.1 Functional
Compound was evaluated for the antagonistic activity against Tachykinin receptor 2Compound was evaluated for the antagonistic activity against Tachykinin receptor 2
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL539021 119445 2 None -2 6 Human 8.1 pIC50 = 8.1 Functional
Compound was evaluated for the antagonistic activity against Tachykinin receptor 2Compound was evaluated for the antagonistic activity against Tachykinin receptor 2
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
44392439 175154 0 None - 1 Rabbit 10.1 pKd = 10.1 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 557 7 1 4 5.2 O=C1CC[C@](CCN2CC(N3CCC(O)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCC(F)(F)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL434548 175154 0 None - 1 Rabbit 10.1 pKd = 10.1 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 557 7 1 4 5.2 O=C1CC[C@](CCN2CC(N3CCC(O)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCC(F)(F)CC1 10.1016/j.bmcl.2005.05.134
11433617 13543 0 None - 0 Human 9.7 pKd = 9.7 Functional
Antagonist activity at NK2 receptor in human urinary bladder assessed as inhibition of [beta-Ala8]NKA(4-10)-induced tissue contractionsAntagonist activity at NK2 receptor in human urinary bladder assessed as inhibition of [beta-Ala8]NKA(4-10)-induced tissue contractions
ChEMBL 630 12 2 6 5.8 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083850 13543 0 None - 0 Human 9.7 pKd = 9.7 Functional
Antagonist activity at NK2 receptor in human urinary bladder assessed as inhibition of [beta-Ala8]NKA(4-10)-induced tissue contractionsAntagonist activity at NK2 receptor in human urinary bladder assessed as inhibition of [beta-Ala8]NKA(4-10)-induced tissue contractions
ChEMBL 630 12 2 6 5.8 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
44392392 136951 0 None - 1 Rabbit 9.7 pKd = 9.7 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 555 7 0 4 5.4 O=C1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CCC(F)(F)CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL367815 136951 0 None - 1 Rabbit 9.7 pKd = 9.7 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 555 7 0 4 5.4 O=C1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CCC(F)(F)CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
44392491 175089 0 None - 1 Rabbit 9.7 pKd = 9.7 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 556 7 1 4 5.2 NC1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CCC(F)(F)CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL434142 175089 0 None - 1 Rabbit 9.7 pKd = 9.7 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 556 7 1 4 5.2 NC1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CCC(F)(F)CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
44392318 129321 0 None - 0 Rabbit 9.6 pKd = 9.6 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 519 7 0 4 5.0 O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1C1(C2CC2)CCCC1 10.1016/j.bmcl.2005.05.134
CHEMBL360134 129321 0 None - 0 Rabbit 9.6 pKd = 9.6 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 519 7 0 4 5.0 O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1C1(C2CC2)CCCC1 10.1016/j.bmcl.2005.05.134
44346720 121613 0 None - 0 Golden hamster 9.3 pKd = 9.3 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 849 14 9 8 1.8 CC(C)C[C@@H]1CN[C@@H](CCC(=O)NCc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL334186 121613 0 None - 0 Golden hamster 9.3 pKd = 9.3 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 849 14 9 8 1.8 CC(C)C[C@@H]1CN[C@@H](CCC(=O)NCc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
71452717 85673 0 None - 0 Rabbit 9.2 pKd = 9.2 Functional
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 678 7 5 6 1.6 O=C1CC(C(=O)N2CCOCC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
CHEMBL2112925 85673 0 None - 0 Rabbit 9.2 pKd = 9.2 Functional
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 678 7 5 6 1.6 O=C1CC(C(=O)N2CCOCC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
9959481 71993 0 None - 1 Human 9.2 pKd = 9.2 Functional
pA2 for NK2 receptor of human bladder IM9 cellspA2 for NK2 receptor of human bladder IM9 cells
ChEMBL 559 7 0 3 6.2 O=C1CC[C@](CCN2CC(N3CCC(F)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCC(F)(F)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL182600 71993 0 None - 1 Human 9.2 pKd = 9.2 Functional
pA2 for NK2 receptor of human bladder IM9 cellspA2 for NK2 receptor of human bladder IM9 cells
ChEMBL 559 7 0 3 6.2 O=C1CC[C@](CCN2CC(N3CCC(F)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCC(F)(F)CC1 10.1016/j.bmcl.2005.05.134
71449111 85670 0 None - 0 Rabbit 9.1 pKd = 9.1 Functional
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 759 8 5 6 3.3 O=C1CC(C(=O)N2CCC(N3CCCCC3)CC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
CHEMBL2112922 85670 0 None - 0 Rabbit 9.1 pKd = 9.1 Functional
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 759 8 5 6 3.3 O=C1CC(C(=O)N2CCC(N3CCCCC3)CC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
44346727 174947 0 None - 0 Golden hamster 9.1 pKd = 9.1 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 784 11 8 7 2.7 CC(C)C[C@@H]1CN[C@@H](CC2CCCCC2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL433191 174947 0 None - 0 Golden hamster 9.1 pKd = 9.1 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 784 11 8 7 2.7 CC(C)C[C@@H]1CN[C@@H](CC2CCCCC2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
44374427 61567 0 None - 0 Rabbit 9.0 pKd = 9 Functional
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 765 12 6 8 0.9 O=C1CC(C(=O)N2CCN(CCOCCO)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
CHEMBL161242 61567 0 None - 0 Rabbit 9.0 pKd = 9 Functional
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 765 12 6 8 0.9 O=C1CC(C(=O)N2CCN(CCOCCO)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
71458042 85671 0 None - 0 Rabbit 9.0 pKd = 9 Functional
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 692 8 5 6 2.0 O=C1C[C@@H](CC(=O)N2CCOCC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
CHEMBL2112923 85671 0 None - 0 Rabbit 9.0 pKd = 9 Functional
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 692 8 5 6 2.0 O=C1C[C@@H](CC(=O)N2CCOCC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
44392351 73176 0 None - 1 Rabbit 9.0 pKd = 9 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 620 8 0 5 4.3 CS(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CCC(F)(F)CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL185182 73176 0 None - 1 Rabbit 9.0 pKd = 9 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 620 8 0 5 4.3 CS(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CCC(F)(F)CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
10929285 73483 0 None - 1 Rabbit 9.0 pKd = 9 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 507 7 0 4 4.8 O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCCCC1 10.1016/j.bmcl.2005.05.134
CHEMBL185572 73483 0 None - 1 Rabbit 9.0 pKd = 9 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 507 7 0 4 4.8 O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCCCC1 10.1016/j.bmcl.2005.05.134
10940813 73105 0 None - 1 Rabbit 8.9 pKd = 8.9 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 571 9 0 5 2.8 CN(C)S(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL185007 73105 0 None - 1 Rabbit 8.9 pKd = 8.9 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 571 9 0 5 2.8 CN(C)S(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
44392347 128906 0 None - 1 Rabbit 8.9 pKd = 8.9 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 543 7 0 4 5.1 O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCC(F)(F)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL359655 128906 0 None - 1 Rabbit 8.9 pKd = 8.9 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 543 7 0 4 5.1 O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCC(F)(F)CC1 10.1016/j.bmcl.2005.05.134
9915372 133837 1 None - 1 Rabbit 8.9 pKd = 8.9 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 543 8 1 5 2.2 NS(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL365613 133837 1 None - 1 Rabbit 8.9 pKd = 8.9 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 543 8 1 5 2.2 NS(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
9915372 133837 1 None - 1 Human 8.8 pKd = 8.8 Functional
pA2 for NK2 receptor of Human bladderpA2 for NK2 receptor of Human bladder
ChEMBL 543 8 1 5 2.2 NS(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL365613 133837 1 None - 1 Human 8.8 pKd = 8.8 Functional
pA2 for NK2 receptor of Human bladderpA2 for NK2 receptor of Human bladder
ChEMBL 543 8 1 5 2.2 NS(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
44392445 73129 0 None - 1 Rabbit 8.8 pKd = 8.8 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 495 8 0 3 5.2 O=C1CC[C@](CCN2CC(N3CCC(F)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CCC1CC1 10.1016/j.bmcl.2005.05.134
CHEMBL185133 73129 0 None - 1 Rabbit 8.8 pKd = 8.8 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 495 8 0 3 5.2 O=C1CC[C@](CCN2CC(N3CCC(F)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CCC1CC1 10.1016/j.bmcl.2005.05.134
44346794 22040 0 None - 0 Golden hamster 8.8 pKd = 8.8 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 828 11 8 7 3.1 CC(C)C[C@@H]1CN[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL121271 22040 0 None - 0 Golden hamster 8.8 pKd = 8.8 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 828 11 8 7 3.1 CC(C)C[C@@H]1CN[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
10972666 129724 0 None - 1 Rabbit 8.7 pKd = 8.7 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 465 7 0 4 3.7 O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1 10.1016/j.bmcl.2005.05.134
CHEMBL360721 129724 0 None - 1 Rabbit 8.7 pKd = 8.7 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 465 7 0 4 3.7 O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1 10.1016/j.bmcl.2005.05.134
10950925 136432 0 None - 1 Rabbit 8.7 pKd = 8.7 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 478 7 1 4 3.8 NC1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL367348 136432 0 None - 1 Rabbit 8.7 pKd = 8.7 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 478 7 1 4 3.8 NC1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
9830361 188405 0 None - 0 Human 8.0 pKd = 8 Functional
Cellular functional antagonistic activity against NKB-induced [Ca2+] mobilization in HEK cells stably expressing the tachykinin receptor 2Cellular functional antagonistic activity against NKB-induced [Ca2+] mobilization in HEK cells stably expressing the tachykinin receptor 2
ChEMBL 538 7 1 4 7.1 C[C@H](NC(=O)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2ccccc2)nc2ccccc12)C1CCCCC1 10.1021/jm000501v
CHEMBL47739 188405 0 None - 0 Human 8.0 pKd = 8 Functional
Cellular functional antagonistic activity against NKB-induced [Ca2+] mobilization in HEK cells stably expressing the tachykinin receptor 2Cellular functional antagonistic activity against NKB-induced [Ca2+] mobilization in HEK cells stably expressing the tachykinin receptor 2
ChEMBL 538 7 1 4 7.1 C[C@H](NC(=O)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2ccccc2)nc2ccccc12)C1CCCCC1 10.1021/jm000501v
10232566 10990 0 None - 0 Human 8.0 pKd = 8 Functional
Functional affinity was evaluated by measuring the intracellular calcium concentration in CHO cells transfected with the human Tachykinin receptor 2 using Fura-2Functional affinity was evaluated by measuring the intracellular calcium concentration in CHO cells transfected with the human Tachykinin receptor 2 using Fura-2
ChEMBL 607 12 2 4 6.1 CN(CCc1c[nH]c2ccccc12)C(=O)c1ccccc1C(=O)N(CCCN1CCSCC1)CCc1c[nH]c2ccccc12 10.1016/s0960-894x(02)00539-5
CHEMBL100297 10990 0 None - 0 Human 8.0 pKd = 8 Functional
Functional affinity was evaluated by measuring the intracellular calcium concentration in CHO cells transfected with the human Tachykinin receptor 2 using Fura-2Functional affinity was evaluated by measuring the intracellular calcium concentration in CHO cells transfected with the human Tachykinin receptor 2 using Fura-2
ChEMBL 607 12 2 4 6.1 CN(CCc1c[nH]c2ccccc12)C(=O)c1ccccc1C(=O)N(CCCN1CCSCC1)CCc1c[nH]c2ccccc12 10.1016/s0960-894x(02)00539-5
44307677 176043 0 None - 0 Guinea pig 8.0 pKd = 8 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL441252 176043 0 None - 0 Guinea pig 8.0 pKd = 8 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44370530 55897 0 None - 0 Rat 7.0 pKd = 7 Functional
Antagonistic activity against Tachykinin receptor 2 was determined in the rat colon muscularis mucosae (RC)Antagonistic activity against Tachykinin receptor 2 was determined in the rat colon muscularis mucosae (RC)
ChEMBL 639 13 4 7 2.6 CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)NC(Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm960213s
CHEMBL156186 55897 0 None - 0 Rat 7.0 pKd = 7 Functional
Antagonistic activity against Tachykinin receptor 2 was determined in the rat colon muscularis mucosae (RC)Antagonistic activity against Tachykinin receptor 2 was determined in the rat colon muscularis mucosae (RC)
ChEMBL 639 13 4 7 2.6 CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)NC(Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm960213s
9810288 210470 0 None - 0 Guinea pig 7.0 pKd = 7 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL67508 210470 0 None - 0 Guinea pig 7.0 pKd = 7 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44346881 148301 0 None - 0 Golden hamster 7.0 pKd = 7 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 923 13 9 9 1.5 CC(C)C[C@H]1NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](CC(=O)N(N)C[C@]23C[C@H]4C[C@H](C[C@H](C4)C2)C3)NC1=O 10.1021/jm00047a020
CHEMBL384610 148301 0 None - 0 Golden hamster 7.0 pKd = 7 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 923 13 9 9 1.5 CC(C)C[C@H]1NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](CC(=O)N(N)C[C@]23C[C@H]4C[C@H](C[C@H](C4)C2)C3)NC1=O 10.1021/jm00047a020
10350528 113510 0 None - 4 Rabbit 5.0 pKd = 5 Functional
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 831 18 4 9 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144210 113510 0 None - 4 Rabbit 5.0 pKd = 5 Functional
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 831 18 4 9 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
10439730 113534 0 None - 4 Rabbit 5.0 pKd = 5 Functional
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 702 12 3 6 3.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144353 113534 0 None - 4 Rabbit 5.0 pKd = 5 Functional
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 702 12 3 6 3.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL413730 219864 0 None - 0 Golden hamster 4.0 pKd = 4 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None None 10.1021/jm00014a022
CHEMBL217365 216153 0 None - 0 Rabbit 4.0 pKd = 4 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
CHEMBL262647 217322 0 None - 0 Rabbit 4.0 pKd = 4 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)O 10.1021/jm00014a022
CHEMBL263985 217379 0 None - 0 Rabbit 4.0 pKd = 4 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
CHEMBL329888 218101 0 None - 0 Rabbit 4.0 pKd = 4 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)O 10.1021/jm00014a022
CHEMBL412621 219789 0 None - 0 Rabbit 4.0 pKd = 4 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O 10.1021/jm00014a022
CHEMBL413730 219864 0 None - 0 Rabbit 4.0 pKd = 4 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None None 10.1021/jm00014a022
44346487 120907 0 None - 0 Rabbit 6.0 pKd = 6.0 Functional
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 746 11 9 8 0.2 CC(C)C[C@@H]1CN[C@@H](CC(=O)O)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL332872 120907 0 None - 0 Rabbit 6.0 pKd = 6.0 Functional
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 746 11 9 8 0.2 CC(C)C[C@@H]1CN[C@@H](CC(=O)O)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
44346706 174948 0 None - 0 Golden hamster 7.0 pKd = 7.0 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 745 11 9 8 -0.4 CC(C)C[C@@H]1CN[C@@H](CC(N)=O)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL433192 174948 0 None - 0 Golden hamster 7.0 pKd = 7.0 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 745 11 9 8 -0.4 CC(C)C[C@@H]1CN[C@@H](CC(N)=O)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL406487 219389 0 None - 0 Golden hamster 6.0 pKd = 6.0 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CC(C)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
44347003 170957 0 None - 0 Rabbit 7.0 pKd = 7.0 Functional
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 744 11 8 7 1.7 CC(C)C[C@@H]1NC[C@@H](CC(C)C)NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC1=O 10.1021/jm00047a020
CHEMBL421062 170957 0 None - 0 Rabbit 7.0 pKd = 7.0 Functional
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 744 11 8 7 1.7 CC(C)C[C@@H]1NC[C@@H](CC(C)C)NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC1=O 10.1021/jm00047a020
CHEMBL216897 216123 0 None - 0 Golden hamster 5.0 pKd = 5.0 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
44346707 121273 0 None - 0 Rabbit 6.9 pKd = 6.9 Functional
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 798 11 7 7 3.0 CC(C)C[C@@H]1CN(C)[C@@H](CC2CCCCC2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL333515 121273 0 None - 0 Rabbit 6.9 pKd = 6.9 Functional
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 798 11 7 7 3.0 CC(C)C[C@@H]1CN(C)[C@@H](CC2CCCCC2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL407328 219433 0 None - 0 Golden hamster 5.9 pKd = 5.9 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
44307898 208252 0 None - 0 Guinea pig 7.9 pKd = 7.9 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL60504 208252 0 None - 0 Guinea pig 7.9 pKd = 7.9 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44347083 22226 0 None - 0 Golden hamster 7.9 pKd = 7.9 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 762 12 8 8 1.4 CSCC[C@@H]1NC[C@@H](CC(C)C)NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC1=O 10.1021/jm00047a020
CHEMBL121571 22226 0 None - 0 Golden hamster 7.9 pKd = 7.9 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 762 12 8 8 1.4 CSCC[C@@H]1NC[C@@H](CC(C)C)NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC1=O 10.1021/jm00047a020
CHEMBL385603 219136 0 None - 0 Golden hamster 5.9 pKd = 5.9 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)O 10.1021/jm00014a022
44307821 108891 0 None - 0 Guinea pig 6.9 pKd = 6.9 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL302329 108891 0 None - 0 Guinea pig 6.9 pKd = 6.9 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
10259370 113525 0 None - 0 Rabbit 6.9 pKd = 6.9 Functional
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 730 12 3 7 3.4 CC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00063a015
CHEMBL3144340 113525 0 None - 0 Rabbit 6.9 pKd = 6.9 Functional
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 730 12 3 7 3.4 CC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00063a015
CHEMBL412189 219754 0 None - 0 Rabbit 5.9 pKd = 5.9 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm00014a022
10418001 113530 0 None - 0 Rabbit 5.9 pKd = 5.9 Functional
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 822 14 3 8 4.9 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCc2ccccc2)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144348 113530 0 None - 0 Rabbit 5.9 pKd = 5.9 Functional
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 822 14 3 8 4.9 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCc2ccccc2)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
10349900 113526 0 None - 4 Rabbit 4.9 pKd = 4.9 Functional
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 716 13 3 7 2.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144343 113526 0 None - 4 Rabbit 4.9 pKd = 4.9 Functional
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 716 13 3 7 2.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
10395494 113531 0 None - 0 Rabbit 4.9 pKd = 4.9 Functional
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 788 12 3 8 4.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144349 113531 0 None - 0 Rabbit 4.9 pKd = 4.9 Functional
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 788 12 3 8 4.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44347084 121030 0 None - 0 Rabbit 6.9 pKd = 6.9 Functional
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 893 16 9 9 2.8 CC(C)C[C@@H]1CN[C@@H](CCCCNC(=O)OCc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL333027 121030 0 None - 0 Rabbit 6.9 pKd = 6.9 Functional
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 893 16 9 9 2.8 CC(C)C[C@@H]1CN[C@@H](CCCCNC(=O)OCc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
44346863 173163 0 None - 0 Rabbit 6.9 pKd = 6.9 Functional
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 909 13 9 9 2.0 CC(C)C[C@@H]1CN[C@@H](CC(=O)N(N)C[C@]23C[C@H]4C[C@H](C[C@H](C4)C2)C3)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL427606 173163 0 None - 0 Rabbit 6.9 pKd = 6.9 Functional
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 909 13 9 9 2.0 CC(C)C[C@@H]1CN[C@@H](CC(=O)N(N)C[C@]23C[C@H]4C[C@H](C[C@H](C4)C2)C3)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL263743 217367 0 None - 0 Rabbit 4.9 pKd = 4.9 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None None 10.1021/jm00014a022
CHEMBL385914 219148 0 None - 0 Rabbit 5.9 pKd = 5.9 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)O 10.1021/jm00014a022
CHEMBL439287 220611 0 None - 0 Golden hamster 5.9 pKd = 5.9 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00014a022
CHEMBL267409 217499 0 None - 0 Golden hamster 6.9 pKd = 6.9 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)O 10.1021/jm00014a022
CHEMBL329888 218101 0 None - 0 Rat 4.9 pKd = 4.9 Functional
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)O 10.1021/jm00014a022
CHEMBL387199 219186 0 None - 0 Golden hamster 5.8 pKd = 5.8 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CSCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)O 10.1021/jm00014a022
44346488 170967 0 None - 0 Rabbit 5.8 pKd = 5.8 Functional
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 798 11 8 7 2.2 CC(C)C[C@H]1NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](CC2CCCCC2)NC1=O 10.1021/jm00047a020
CHEMBL421071 170967 0 None - 0 Rabbit 5.8 pKd = 5.8 Functional
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 798 11 8 7 2.2 CC(C)C[C@H]1NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](CC2CCCCC2)NC1=O 10.1021/jm00047a020
CHEMBL267409 217499 0 None - 0 Rabbit 5.8 pKd = 5.8 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)O 10.1021/jm00014a022
CHEMBL329888 218101 0 None - 0 Golden hamster 4.8 pKd = 4.8 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)O 10.1021/jm00014a022
44346720 121613 0 None - 0 Rabbit 7.8 pKd = 7.8 Functional
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 849 14 9 8 1.8 CC(C)C[C@@H]1CN[C@@H](CCC(=O)NCc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL334186 121613 0 None - 0 Rabbit 7.8 pKd = 7.8 Functional
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 849 14 9 8 1.8 CC(C)C[C@@H]1CN[C@@H](CCC(=O)NCc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
44307679 210296 0 None - 0 Guinea pig 7.8 pKd = 7.8 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
CHEMBL66332 210296 0 None - 0 Guinea pig 7.8 pKd = 7.8 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
44347003 170957 0 None - 0 Golden hamster 7.8 pKd = 7.8 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 744 11 8 7 1.7 CC(C)C[C@@H]1NC[C@@H](CC(C)C)NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC1=O 10.1021/jm00047a020
CHEMBL421062 170957 0 None - 0 Golden hamster 7.8 pKd = 7.8 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 744 11 8 7 1.7 CC(C)C[C@@H]1NC[C@@H](CC(C)C)NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC1=O 10.1021/jm00047a020
CHEMBL439287 220611 0 None - 0 Rat 6.8 pKd = 6.8 Functional
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00014a022
CHEMBL217365 216153 0 None - 0 Golden hamster 4.8 pKd = 4.8 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
44307773 109137 0 None - 0 Guinea pig 6.8 pKd = 6.8 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 779 13 0 7 7.6 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)C3CCN(C)CC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL303803 109137 0 None - 0 Guinea pig 6.8 pKd = 6.8 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 779 13 0 7 7.6 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)C3CCN(C)CC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL429340 220301 0 None - 0 Golden hamster 5.8 pKd = 5.8 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
CHEMBL439284 220610 22 None - 0 Rabbit 5.8 pKd = 5.8 Functional
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](N)CCCN=C(N)N)C(N)=O 10.1021/jm00063a015
10395612 113524 0 None - 0 Rabbit 4.8 pKd = 4.8 Functional
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 814 18 3 7 5.7 CCCCCCCC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00063a015
CHEMBL3144339 113524 0 None - 0 Rabbit 4.8 pKd = 4.8 Functional
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 814 18 3 7 5.7 CCCCCCCC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00063a015
10032981 113529 0 None - 0 Rabbit 4.8 pKd = 4.8 Functional
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 746 12 3 8 3.3 COC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00063a015
CHEMBL3144347 113529 0 None - 0 Rabbit 4.8 pKd = 4.8 Functional
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 746 12 3 8 3.3 COC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00063a015
9832198 113532 0 None - 4 Rabbit 4.8 pKd = 4.8 Functional
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 788 15 4 8 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCC(=O)O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144351 113532 0 None - 4 Rabbit 4.8 pKd = 4.8 Functional
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 788 15 4 8 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCC(=O)O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL385603 219136 0 None - 0 Rabbit 5.8 pKd = 5.8 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)O 10.1021/jm00014a022
CHEMBL439287 220611 0 None - 0 Rabbit 5.8 pKd = 5.8 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00014a022
CHEMBL268563 217538 0 None - 0 Rabbit 5.8 pKd = 5.8 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CCC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm00014a022
CHEMBL268563 217538 0 None - 0 Golden hamster 5.8 pKd = 5.8 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CCC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm00014a022
CHEMBL412621 219789 0 None - 0 Golden hamster 5.8 pKd = 5.8 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O 10.1021/jm00014a022
CHEMBL263743 217367 0 None - 0 Golden hamster 4.8 pKd = 4.8 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None None 10.1021/jm00014a022
44347002 119611 0 None - 0 Golden hamster 7.7 pKd = 7.7 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 778 11 8 7 1.9 CC(C)C[C@@H]1CN[C@@H](Cc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL330810 119611 0 None - 0 Golden hamster 7.7 pKd = 7.7 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 778 11 8 7 1.9 CC(C)C[C@@H]1CN[C@@H](Cc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL438716 220567 0 None - 0 Rat 4.7 pKd = 4.7 Functional
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
9874206 210550 0 None - 0 Guinea pig 7.7 pKd = 7.7 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL68060 210550 0 None - 0 Guinea pig 7.7 pKd = 7.7 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL412621 219789 0 None - 0 Rat 6.7 pKd = 6.7 Functional
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O 10.1021/jm00014a022
CHEMBL263997 217380 0 None - 0 Rabbit 6.7 pKd = 6.7 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
CHEMBL441181 220660 0 None - 0 Rat 5.7 pKd = 5.7 Functional
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None CSCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)O 10.1021/jm00014a022
CHEMBL438716 220567 0 None - 0 Rabbit 4.7 pKd = 4.7 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
57391133 75142 0 None - 0 Human 6.7 pKd = 6.7 Functional
Antagonist activity at human NK2 receptor expressed in CHO cells assessed as inhibition of Neurokinin A-induced increase in intracellular Ca2+ increase by Fura-2 assayAntagonist activity at human NK2 receptor expressed in CHO cells assessed as inhibition of Neurokinin A-induced increase in intracellular Ca2+ increase by Fura-2 assay
ChEMBL 691 12 3 7 4.4 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)N2C(=O)C(NC(=O)OCc2ccccc2)C1 10.1016/j.ejmech.2011.08.042
CHEMBL1916635 75142 0 None - 0 Human 6.7 pKd = 6.7 Functional
Antagonist activity at human NK2 receptor expressed in CHO cells assessed as inhibition of Neurokinin A-induced increase in intracellular Ca2+ increase by Fura-2 assayAntagonist activity at human NK2 receptor expressed in CHO cells assessed as inhibition of Neurokinin A-induced increase in intracellular Ca2+ increase by Fura-2 assay
ChEMBL 691 12 3 7 4.4 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)N2C(=O)C(NC(=O)OCc2ccccc2)C1 10.1016/j.ejmech.2011.08.042
44370713 57806 0 None - 0 Rat 6.7 pKd = 6.7 Functional
Antagonistic activity against Tachykinin receptor 2 was determined in the rat colon muscularis mucosae (RC)Antagonistic activity against Tachykinin receptor 2 was determined in the rat colon muscularis mucosae (RC)
ChEMBL 653 13 4 7 3.2 CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)NC(Cc1ccccc1)C(=O)N(C)C(C)c1ccccc1)C(C)O 10.1021/jm960213s
CHEMBL157858 57806 0 None - 0 Rat 6.7 pKd = 6.7 Functional
Antagonistic activity against Tachykinin receptor 2 was determined in the rat colon muscularis mucosae (RC)Antagonistic activity against Tachykinin receptor 2 was determined in the rat colon muscularis mucosae (RC)
ChEMBL 653 13 4 7 3.2 CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)NC(Cc1ccccc1)C(=O)N(C)C(C)c1ccccc1)C(C)O 10.1021/jm960213s
10055415 113533 0 None - 4 Rabbit 5.7 pKd = 5.7 Functional
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 688 12 4 5 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144352 113533 0 None - 4 Rabbit 5.7 pKd = 5.7 Functional
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 688 12 4 5 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
3086681 9052 17 None - 1 Rabbit 4.7 pKd = 4.7 Functional
Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 10.1021/jm950616c
3510 9052 17 None - 1 Rabbit 4.7 pKd = 4.7 Functional
Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 10.1021/jm950616c
CHEMBL42407 9052 17 None - 1 Rabbit 4.7 pKd = 4.7 Functional
Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 10.1021/jm950616c
10325464 126912 0 None - 1 Rabbit 4.7 pKd = 4.7 Functional
Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL351236 126912 0 None - 1 Rabbit 4.7 pKd = 4.7 Functional
Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
10506928 126996 0 None - 1 Rabbit 4.7 pKd = 4.7 Functional
Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2
ChEMBL 553 11 2 5 4.1 COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL352102 126996 0 None - 1 Rabbit 4.7 pKd = 4.7 Functional
Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2
ChEMBL 553 11 2 5 4.1 COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
10350454 113508 0 None - 4 Rabbit 4.7 pKd = 4.7 Functional
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 815 18 4 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144209 113508 0 None - 4 Rabbit 4.7 pKd = 4.7 Functional
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 815 18 4 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44347001 119961 0 None - 0 Golden hamster 8.7 pKd = 8.7 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 851 15 9 9 2.0 CC(C)C[C@@H]1CN[C@@H](CCC(N)OCc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL331480 119961 0 None - 0 Golden hamster 8.7 pKd = 8.7 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 851 15 9 9 2.0 CC(C)C[C@@H]1CN[C@@H](CCC(N)OCc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
44374556 59505 0 None - 0 Rabbit 8.6 pKd = 8.6 Functional
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 773 9 5 6 3.7 O=C1C[C@@H](CC(=O)N2CCC(N3CCCCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
CHEMBL159449 59505 0 None - 0 Rabbit 8.6 pKd = 8.6 Functional
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 773 9 5 6 3.7 O=C1C[C@@H](CC(=O)N2CCC(N3CCCCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
44392444 129112 0 None - 1 Rabbit 8.6 pKd = 8.6 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 481 7 0 3 4.8 O=C1CC[C@](CCN2CC(N3CCC(F)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1 10.1016/j.bmcl.2005.05.134
CHEMBL359903 129112 0 None - 1 Rabbit 8.6 pKd = 8.6 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 481 7 0 3 4.8 O=C1CC[C@](CCN2CC(N3CCC(F)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1 10.1016/j.bmcl.2005.05.134
CHEMBL429340 220301 0 None - 0 Rabbit 7.7 pKd = 7.7 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
CHEMBL263997 217380 0 None - 0 Rat 6.7 pKd = 6.7 Functional
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
44347083 22226 0 None - 0 Rabbit 6.7 pKd = 6.7 Functional
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 762 12 8 8 1.4 CSCC[C@@H]1NC[C@@H](CC(C)C)NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC1=O 10.1021/jm00047a020
CHEMBL121571 22226 0 None - 0 Rabbit 6.7 pKd = 6.7 Functional
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 762 12 8 8 1.4 CSCC[C@@H]1NC[C@@H](CC(C)C)NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC1=O 10.1021/jm00047a020
CHEMBL334721 218178 1 None - 2 Guinea pig 7.6 pKd = 7.6 Functional
Compound was evaluated for antagonistic activity towards Tachykinin receptor 2 at guinea pig tracheaCompound was evaluated for antagonistic activity towards Tachykinin receptor 2 at guinea pig trachea
ChEMBL None None None CSCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CNC(=O)C[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2 10.1016/s0960-894x(98)00282-0
CHEMBL263985 217379 0 None - 0 Rat 5.6 pKd = 5.6 Functional
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
9918520 109528 0 None - 0 Guinea pig 7.6 pKd = 7.6 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL305055 109528 0 None - 0 Guinea pig 7.6 pKd = 7.6 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL429340 220301 0 None - 0 Rat 6.6 pKd = 6.6 Functional
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
CHEMBL217365 216153 0 None - 0 Rat 4.6 pKd = 4.6 Functional
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None CC(C)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
CHEMBL266526 217465 0 None - 0 Rabbit 6.6 pKd = 6.6 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CC(C)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
CHEMBL412830 219810 0 None - 0 Rabbit 5.6 pKd = 5.6 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(=O)O)C(=O)O 10.1021/jm00014a022
CHEMBL412189 219754 0 None - 0 Rat 6.5 pKd = 6.5 Functional
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm00014a022
CHEMBL385914 219148 0 None - 0 Rat 6.5 pKd = 6.5 Functional
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)O 10.1021/jm00014a022
71449112 85674 0 None - 0 Rabbit 8.5 pKd = 8.5 Functional
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 682 10 8 7 0.3 O=C1CC(C(=O)NC(CO)CO)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
CHEMBL2112926 85674 0 None - 0 Rabbit 8.5 pKd = 8.5 Functional
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 682 10 8 7 0.3 O=C1CC(C(=O)NC(CO)CO)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
44374557 126373 0 None - 0 Rabbit 8.5 pKd = 8.5 Functional
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 693 11 6 6 1.9 CN(C)CCNC(=O)C[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1016/s0960-894x(01)00841-1
CHEMBL346285 126373 0 None - 0 Rabbit 8.5 pKd = 8.5 Functional
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 693 11 6 6 1.9 CN(C)CCNC(=O)C[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1016/s0960-894x(01)00841-1
9807403 73458 0 None - 1 Rabbit 8.5 pKd = 8.5 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 542 8 0 5 2.9 CS(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL185452 73458 0 None - 1 Rabbit 8.5 pKd = 8.5 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 542 8 0 5 2.9 CS(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
44346707 121273 0 None - 0 Golden hamster 8.4 pKd = 8.4 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 798 11 7 7 3.0 CC(C)C[C@@H]1CN(C)[C@@H](CC2CCCCC2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL333515 121273 0 None - 0 Golden hamster 8.4 pKd = 8.4 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 798 11 7 7 3.0 CC(C)C[C@@H]1CN(C)[C@@H](CC2CCCCC2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
44370529 55833 0 None - 0 Rat 8.4 pKd = 8.4 Functional
Antagonistic activity against Tachykinin receptor 2 was determined in the rat colon muscularis mucosae (RC)Antagonistic activity against Tachykinin receptor 2 was determined in the rat colon muscularis mucosae (RC)
ChEMBL 643 10 3 7 3.0 CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)N1C(C(=O)N(C)Cc2ccccc2)CC2CCCCC21)C(C)O 10.1021/jm960213s
CHEMBL156128 55833 0 None - 0 Rat 8.4 pKd = 8.4 Functional
Antagonistic activity against Tachykinin receptor 2 was determined in the rat colon muscularis mucosae (RC)Antagonistic activity against Tachykinin receptor 2 was determined in the rat colon muscularis mucosae (RC)
ChEMBL 643 10 3 7 3.0 CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)N1C(C(=O)N(C)Cc2ccccc2)CC2CCCCC21)C(C)O 10.1021/jm960213s
10305816 10991 1 None - 0 Human 8.4 pKd = 8.4 Functional
Functional affinity was evaluated by measuring the intracellular calcium concentration in CHO cells transfected with the human Tachykinin receptor 2 using Fura-2Functional affinity was evaluated by measuring the intracellular calcium concentration in CHO cells transfected with the human Tachykinin receptor 2 using Fura-2
ChEMBL 736 16 2 6 6.9 O=C(c1ccccc1C(=O)N(CCCN1CCSCC1)CCc1c[nH]c2ccccc12)N(CCCN1CCSCC1)CCc1c[nH]c2ccccc12 10.1016/s0960-894x(02)00539-5
CHEMBL100298 10991 1 None - 0 Human 8.4 pKd = 8.4 Functional
Functional affinity was evaluated by measuring the intracellular calcium concentration in CHO cells transfected with the human Tachykinin receptor 2 using Fura-2Functional affinity was evaluated by measuring the intracellular calcium concentration in CHO cells transfected with the human Tachykinin receptor 2 using Fura-2
ChEMBL 736 16 2 6 6.9 O=C(c1ccccc1C(=O)N(CCCN1CCSCC1)CCc1c[nH]c2ccccc12)N(CCCN1CCSCC1)CCc1c[nH]c2ccccc12 10.1016/s0960-894x(02)00539-5
44374543 59669 0 None - 0 Rabbit 8.4 pKd = 8.4 Functional
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 773 9 5 6 3.7 O=C1C[C@H](CC(=O)N2CCC(N3CCCCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
CHEMBL159585 59669 0 None - 0 Rabbit 8.4 pKd = 8.4 Functional
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 773 9 5 6 3.7 O=C1C[C@H](CC(=O)N2CCC(N3CCCCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
44374598 126269 0 None - 0 Rabbit 8.4 pKd = 8.4 Functional
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 811 10 10 10 -1.2 CC(=O)NC1C(NC(=O)C2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)OC(CO)C(O)C1O 10.1016/s0960-894x(01)00841-1
CHEMBL345402 126269 0 None - 0 Rabbit 8.4 pKd = 8.4 Functional
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 811 10 10 10 -1.2 CC(=O)NC1C(NC(=O)C2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)OC(CO)C(O)C1O 10.1016/s0960-894x(01)00841-1
CHEMBL412830 219810 0 None - 0 Rat 7.5 pKd = 7.5 Functional
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(=O)O)C(=O)O 10.1021/jm00014a022
44346486 120900 0 None - 0 Golden hamster 6.5 pKd = 6.5 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 759 13 9 8 0.8 CC(C)C[C@@H]1CN[C@@H](CCCCN)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL332820 120900 0 None - 0 Golden hamster 6.5 pKd = 6.5 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 759 13 9 8 0.8 CC(C)C[C@@H]1CN[C@@H](CCCCN)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
44346488 170967 0 None - 0 Golden hamster 7.5 pKd = 7.5 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 798 11 8 7 2.2 CC(C)C[C@H]1NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](CC2CCCCC2)NC1=O 10.1021/jm00047a020
CHEMBL421071 170967 0 None - 0 Golden hamster 7.5 pKd = 7.5 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 798 11 8 7 2.2 CC(C)C[C@H]1NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](CC2CCCCC2)NC1=O 10.1021/jm00047a020
10145229 15945 0 None - 0 Golden hamster 6.5 pKd = 6.5 Functional
Inhibition of NKA-induced airway contraction of isolated hamster trachea (ht) was used as a measure of NK2-receptor antagonist activity.Inhibition of NKA-induced airway contraction of isolated hamster trachea (ht) was used as a measure of NK2-receptor antagonist activity.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL110219 15945 0 None - 0 Golden hamster 6.5 pKd = 6.5 Functional
Inhibition of NKA-induced airway contraction of isolated hamster trachea (ht) was used as a measure of NK2-receptor antagonist activity.Inhibition of NKA-induced airway contraction of isolated hamster trachea (ht) was used as a measure of NK2-receptor antagonist activity.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL263985 217379 0 None - 0 Golden hamster 4.5 pKd = 4.5 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
44305816 169798 0 None - 0 Rabbit 4.5 pKd = 4.5 Functional
Antagonistic potency for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.Antagonistic potency for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.
ChEMBL 589 8 2 4 3.6 CN(Cc1ccccc1)C(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)C1C=[N+](C)c2ccccc21 10.1016/S0960-894X(96)00604-X
CHEMBL417572 169798 0 None - 0 Rabbit 4.5 pKd = 4.5 Functional
Antagonistic potency for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.Antagonistic potency for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.
ChEMBL 589 8 2 4 3.6 CN(Cc1ccccc1)C(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)C1C=[N+](C)c2ccccc21 10.1016/S0960-894X(96)00604-X
CHEMBL216897 216123 0 None - 0 Rat 6.5 pKd = 6.5 Functional
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
CHEMBL267409 217499 0 None - 0 Rat 7.5 pKd = 7.5 Functional
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)O 10.1021/jm00014a022
CHEMBL407328 219433 0 None - 0 Rat 6.5 pKd = 6.5 Functional
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
CHEMBL385914 219148 0 None - 0 Golden hamster 6.5 pKd = 6.5 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)O 10.1021/jm00014a022
44346727 174947 0 None - 0 Rabbit 7.4 pKd = 7.4 Functional
Tested for agonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery at a concentration of 3-10 uMTested for agonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery at a concentration of 3-10 uM
ChEMBL 784 11 8 7 2.7 CC(C)C[C@@H]1CN[C@@H](CC2CCCCC2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL433191 174947 0 None - 0 Rabbit 7.4 pKd = 7.4 Functional
Tested for agonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery at a concentration of 3-10 uMTested for agonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery at a concentration of 3-10 uM
ChEMBL 784 11 8 7 2.7 CC(C)C[C@@H]1CN[C@@H](CC2CCCCC2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL266526 217465 0 None - 0 Rat 6.4 pKd = 6.4 Functional
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None CC(C)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
CHEMBL387199 219186 0 None - 0 Rat 6.4 pKd = 6.4 Functional
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None CSCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)O 10.1021/jm00014a022
44307819 109373 0 None - 0 Guinea pig 7.4 pKd = 7.4 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL304106 109373 0 None - 0 Guinea pig 7.4 pKd = 7.4 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44307678 205454 0 None - 0 Guinea pig 7.4 pKd = 7.4 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
CHEMBL57993 205454 0 None - 0 Guinea pig 7.4 pKd = 7.4 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
44307820 210414 0 None - 0 Guinea pig 7.4 pKd = 7.4 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL67171 210414 0 None - 0 Guinea pig 7.4 pKd = 7.4 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
21121353 108250 0 None - 4 Rabbit 5.4 pKd = 5.4 Functional
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 625 14 4 7 2.0 CC(=O)N[C@H](C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm00063a015
CHEMBL297776 108250 0 None - 4 Rabbit 5.4 pKd = 5.4 Functional
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 625 14 4 7 2.0 CC(=O)N[C@H](C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm00063a015
44346863 173163 0 None - 0 Golden hamster 8.4 pKd = 8.4 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 909 13 9 9 2.0 CC(C)C[C@@H]1CN[C@@H](CC(=O)N(N)C[C@]23C[C@H]4C[C@H](C[C@H](C4)C2)C3)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL427606 173163 0 None - 0 Golden hamster 8.4 pKd = 8.4 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 909 13 9 9 2.0 CC(C)C[C@@H]1CN[C@@H](CC(=O)N(N)C[C@]23C[C@H]4C[C@H](C[C@H](C4)C2)C3)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL406487 219389 0 None - 0 Rabbit 6.4 pKd = 6.4 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CC(C)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
CHEMBL262647 217322 0 None - 0 Golden hamster 5.4 pKd = 5.4 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)O 10.1021/jm00014a022
44346794 22040 0 None - 0 Rabbit 7.4 pKd = 7.4 Functional
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 828 11 8 7 3.1 CC(C)C[C@@H]1CN[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL121271 22040 0 None - 0 Rabbit 7.4 pKd = 7.4 Functional
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 828 11 8 7 3.1 CC(C)C[C@@H]1CN[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL412830 219810 0 None - 0 Golden hamster 6.4 pKd = 6.4 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(=O)O)C(=O)O 10.1021/jm00014a022
CHEMBL263743 217367 0 None - 0 Rat 5.4 pKd = 5.4 Functional
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None None 10.1021/jm00014a022
CHEMBL441181 220660 0 None - 0 Rabbit 5.3 pKd = 5.3 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CSCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)O 10.1021/jm00014a022
9829402 175279 0 None - 0 Rabbit 8.3 pKd = 8.3 Functional
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 565 6 5 4 2.6 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1 10.1016/s0960-894x(01)00841-1
CHEMBL435324 175279 0 None - 0 Rabbit 8.3 pKd = 8.3 Functional
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 565 6 5 4 2.6 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1 10.1016/s0960-894x(01)00841-1
1488931 58335 15 None - 0 Guinea pig 7.3 pKd = 7.3 Functional
Compound was evaluated for NK-2 receptor antagonistic activity in the guinea pig tracheaCompound was evaluated for NK-2 receptor antagonistic activity in the guinea pig trachea
ChEMBL 344 2 0 6 3.8 O=c1c2cnn(-c3ccccc3)c2nc2scc(-c3ccccc3)n12 10.1016/0960-894X(95)00558-B
CHEMBL158318 58335 15 None - 0 Guinea pig 7.3 pKd = 7.3 Functional
Compound was evaluated for NK-2 receptor antagonistic activity in the guinea pig tracheaCompound was evaluated for NK-2 receptor antagonistic activity in the guinea pig trachea
ChEMBL 344 2 0 6 3.8 O=c1c2cnn(-c3ccccc3)c2nc2scc(-c3ccccc3)n12 10.1016/0960-894X(95)00558-B
9896563 110557 0 None - 0 Guinea pig 7.3 pKd = 7.3 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CCC(/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
CHEMBL308891 110557 0 None - 0 Guinea pig 7.3 pKd = 7.3 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CCC(/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
9939307 210265 0 None - 0 Guinea pig 7.3 pKd = 7.3 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL66106 210265 0 None - 0 Guinea pig 7.3 pKd = 7.3 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44307757 210315 0 None - 0 Guinea pig 7.3 pKd = 7.3 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL66441 210315 0 None - 0 Guinea pig 7.3 pKd = 7.3 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44307758 210335 0 None - 0 Guinea pig 7.3 pKd = 7.3 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL66635 210335 0 None - 0 Guinea pig 7.3 pKd = 7.3 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
9810835 210354 0 None - 0 Guinea pig 7.3 pKd = 7.3 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL66763 210354 0 None - 0 Guinea pig 7.3 pKd = 7.3 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44307741 210566 0 None - 0 Guinea pig 6.3 pKd = 6.3 Functional
In vivo NK2 activity is characterized by the compound ability to inhibit guinea pig bronchoconstrictionIn vivo NK2 activity is characterized by the compound ability to inhibit guinea pig bronchoconstriction
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL68234 210566 0 None - 0 Guinea pig 6.3 pKd = 6.3 Functional
In vivo NK2 activity is characterized by the compound ability to inhibit guinea pig bronchoconstrictionIn vivo NK2 activity is characterized by the compound ability to inhibit guinea pig bronchoconstriction
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
104943 62160 39 None - 4 Rabbit 4.3 pKd = 4.3 Functional
Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950616c
CHEMBL16192 62160 39 None - 4 Rabbit 4.3 pKd = 4.3 Functional
Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950616c
44347001 119961 0 None - 0 Rabbit 7.3 pKd = 7.3 Functional
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 851 15 9 9 2.0 CC(C)C[C@@H]1CN[C@@H](CCC(N)OCc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL331480 119961 0 None - 0 Rabbit 7.3 pKd = 7.3 Functional
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 851 15 9 9 2.0 CC(C)C[C@@H]1CN[C@@H](CCC(N)OCc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
9939040 11782 7 None - 2 Guinea pig 7.3 pKd = 7.3 Functional
In vitro relative antagonist potency towards guinea pig Tachykinin receptor 2In vitro relative antagonist potency towards guinea pig Tachykinin receptor 2
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
CHEMBL105060 11782 7 None - 2 Guinea pig 7.3 pKd = 7.3 Functional
In vitro relative antagonist potency towards guinea pig Tachykinin receptor 2In vitro relative antagonist potency towards guinea pig Tachykinin receptor 2
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
CHEMBL266526 217465 0 None - 0 Golden hamster 6.3 pKd = 6.3 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CC(C)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
CHEMBL327457 218072 0 None - 0 Rabbit 5.2 pKd = 5.2 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CC(=O)O)C(=O)O 10.1021/jm00014a022
CHEMBL334721 218178 1 None - 2 Rat 8.2 pKd = 8.2 Functional
Compound was evaluated for antagonistic activity towards Tachykinin receptor 2 in rat vas deferensCompound was evaluated for antagonistic activity towards Tachykinin receptor 2 in rat vas deferens
ChEMBL None None None CSCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CNC(=O)C[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2 10.1016/s0960-894x(98)00282-0
44374504 61623 0 None - 0 Rabbit 8.2 pKd = 8.2 Functional
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 825 11 10 10 -0.8 CC(=O)NC1C(NC(=O)C[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)OC(CO)C(O)C1O 10.1016/s0960-894x(01)00841-1
CHEMBL161288 61623 0 None - 0 Rabbit 8.2 pKd = 8.2 Functional
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 825 11 10 10 -0.8 CC(=O)NC1C(NC(=O)C[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)OC(CO)C(O)C1O 10.1016/s0960-894x(01)00841-1
71461644 85672 0 None - 0 Rabbit 8.2 pKd = 8.2 Functional
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 784 10 10 10 -0.9 O=C(C[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)CNC1=O)NC1OC(CO)C(O)C(O)C1O 10.1016/s0960-894x(01)00841-1
CHEMBL2112924 85672 0 None - 0 Rabbit 8.2 pKd = 8.2 Functional
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 784 10 10 10 -0.9 O=C(C[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)CNC1=O)NC1OC(CO)C(O)C(O)C1O 10.1016/s0960-894x(01)00841-1
11038500 70327 0 None - 1 Rabbit 8.2 pKd = 8.2 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 507 9 0 4 4.8 CCOC1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL180049 70327 0 None - 1 Rabbit 8.2 pKd = 8.2 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 507 9 0 4 4.8 CCOC1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
44347084 121030 0 None - 0 Golden hamster 8.2 pKd = 8.2 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 893 16 9 9 2.8 CC(C)C[C@@H]1CN[C@@H](CCCCNC(=O)OCc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL333027 121030 0 None - 0 Golden hamster 8.2 pKd = 8.2 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 893 16 9 9 2.8 CC(C)C[C@@H]1CN[C@@H](CCCCNC(=O)OCc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
9875181 178122 0 None - 0 Guinea pig 7.2 pKd = 7.2 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL446146 178122 0 None - 0 Guinea pig 7.2 pKd = 7.2 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
57391132 75141 0 None - 0 Human 6.2 pKd = 6.2 Functional
Antagonist activity at human NK2 receptor expressed in CHO cells assessed as inhibition of Neurokinin A-induced increase in intracellular Ca2+ increase by Fura-2 assayAntagonist activity at human NK2 receptor expressed in CHO cells assessed as inhibition of Neurokinin A-induced increase in intracellular Ca2+ increase by Fura-2 assay
ChEMBL 599 10 3 6 2.6 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)N2C(=O)C(NC(C)=O)C1 10.1016/j.ejmech.2011.08.042
CHEMBL1916634 75141 0 None - 0 Human 6.2 pKd = 6.2 Functional
Antagonist activity at human NK2 receptor expressed in CHO cells assessed as inhibition of Neurokinin A-induced increase in intracellular Ca2+ increase by Fura-2 assayAntagonist activity at human NK2 receptor expressed in CHO cells assessed as inhibition of Neurokinin A-induced increase in intracellular Ca2+ increase by Fura-2 assay
ChEMBL 599 10 3 6 2.6 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)N2C(=O)C(NC(C)=O)C1 10.1016/j.ejmech.2011.08.042
44307953 175973 0 None - 0 Guinea pig 6.2 pKd = 6.2 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 784 12 1 7 6.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)[S+]3CCNCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL440679 175973 0 None - 0 Guinea pig 6.2 pKd = 6.2 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 784 12 1 7 6.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)[S+]3CCNCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL540651 175973 0 None - 0 Guinea pig 6.2 pKd = 6.2 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 784 12 1 7 6.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)[S+]3CCNCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL438716 220567 0 None - 0 Golden hamster 5.2 pKd = 5.2 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
CHEMBL216897 216123 0 None - 0 Rabbit 5.2 pKd = 5.2 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
132837 9018 55 None - 4 Rabbit 5.2 pKd = 5.2 Functional
Antagonistic potency for NK-2 receptor was determined in vitro, using isolated rabbit pulmonary artery.Antagonistic potency for NK-2 receptor was determined in vitro, using isolated rabbit pulmonary artery.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/S0960-894X(96)00604-X
9461 9018 55 None - 4 Rabbit 5.2 pKd = 5.2 Functional
Antagonistic potency for NK-2 receptor was determined in vitro, using isolated rabbit pulmonary artery.Antagonistic potency for NK-2 receptor was determined in vitro, using isolated rabbit pulmonary artery.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/S0960-894X(96)00604-X
CHEMBL22870 9018 55 None - 4 Rabbit 5.2 pKd = 5.2 Functional
Antagonistic potency for NK-2 receptor was determined in vitro, using isolated rabbit pulmonary artery.Antagonistic potency for NK-2 receptor was determined in vitro, using isolated rabbit pulmonary artery.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/S0960-894X(96)00604-X
CHEMBL407328 219433 0 None - 0 Rabbit 7.2 pKd = 7.2 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
CHEMBL263997 217380 0 None - 0 Golden hamster 6.2 pKd = 6.2 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
CHEMBL441181 220660 0 None - 0 Golden hamster 5.2 pKd = 5.2 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CSCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)O 10.1021/jm00014a022
44346487 120907 0 None - 0 Golden hamster 7.2 pKd = 7.2 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 746 11 9 8 0.2 CC(C)C[C@@H]1CN[C@@H](CC(=O)O)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL332872 120907 0 None - 0 Golden hamster 7.2 pKd = 7.2 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 746 11 9 8 0.2 CC(C)C[C@@H]1CN[C@@H](CC(=O)O)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
44346706 174948 0 None - 0 Rabbit 6.2 pKd = 6.2 Functional
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 745 11 9 8 -0.4 CC(C)C[C@@H]1CN[C@@H](CC(N)=O)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL433192 174948 0 None - 0 Rabbit 6.2 pKd = 6.2 Functional
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 745 11 9 8 -0.4 CC(C)C[C@@H]1CN[C@@H](CC(N)=O)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
44374622 126841 0 None - 0 Rabbit 8.1 pKd = 8.1 Functional
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 825 11 10 10 -0.8 CC(=O)NC1C(NC(=O)C[C@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)OC(CO)C(O)C1O 10.1016/s0960-894x(01)00841-1
CHEMBL350596 126841 0 None - 0 Rabbit 8.1 pKd = 8.1 Functional
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 825 11 10 10 -0.8 CC(=O)NC1C(NC(=O)C[C@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)OC(CO)C(O)C1O 10.1016/s0960-894x(01)00841-1
CHEMBL327457 218072 0 None - 0 Rat 5.1 pKd = 5.1 Functional
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CC(=O)O)C(=O)O 10.1021/jm00014a022
CHEMBL385603 219136 0 None - 0 Rat 7.1 pKd = 7.1 Functional
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)O 10.1021/jm00014a022
44347002 119611 0 None - 0 Rabbit 7.1 pKd = 7.1 Functional
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 778 11 8 7 1.9 CC(C)C[C@@H]1CN[C@@H](Cc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL330810 119611 0 None - 0 Rabbit 7.1 pKd = 7.1 Functional
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 778 11 8 7 1.9 CC(C)C[C@@H]1CN[C@@H](Cc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
44346881 148301 0 None - 0 Rabbit 5.1 pKd = 5.1 Functional
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 923 13 9 9 1.5 CC(C)C[C@H]1NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](CC(=O)N(N)C[C@]23C[C@H]4C[C@H](C[C@H](C4)C2)C3)NC1=O 10.1021/jm00047a020
CHEMBL384610 148301 0 None - 0 Rabbit 5.1 pKd = 5.1 Functional
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 923 13 9 9 1.5 CC(C)C[C@H]1NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](CC(=O)N(N)C[C@]23C[C@H]4C[C@H](C[C@H](C4)C2)C3)NC1=O 10.1021/jm00047a020
CHEMBL406487 219389 0 None - 0 Rat 6.1 pKd = 6.1 Functional
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None CC(C)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
CHEMBL387199 219186 0 None - 0 Rabbit 7.1 pKd = 7.1 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CSCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)O 10.1021/jm00014a022
CHEMBL327457 218072 0 None - 0 Golden hamster 5.0 pKd = 5.0 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CC(=O)O)C(=O)O 10.1021/jm00014a022
CHEMBL412189 219754 0 None - 0 Golden hamster 6.0 pKd = 6.0 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm00014a022
CHEMBL413730 219864 0 None - 0 Rat 5.0 pKd = 5.0 Functional
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None None 10.1021/jm00014a022
44434204 160347 0 None - 0 Guinea pig 7.0 pKi = 7 Functional
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 610 11 3 6 3.7 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)Cc2ccccc2C1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
CHEMBL398028 160347 0 None - 0 Guinea pig 7.0 pKi = 7 Functional
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 610 11 3 6 3.7 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)Cc2ccccc2C1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
10166998 173460 0 None - 0 Guinea pig 7.0 pKi = 7 Functional
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 576 11 3 6 3.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCCC1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
CHEMBL428203 173460 0 None - 0 Guinea pig 7.0 pKi = 7 Functional
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 576 11 3 6 3.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCCC1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
44434205 96177 0 None - 0 Guinea pig 6.9 pKi = 6.9 Functional
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 623 11 3 6 3.7 CN1CCN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)Cc3ccccc3C2)CC1 10.1016/j.bmcl.2007.06.053
CHEMBL237048 96177 0 None - 0 Guinea pig 6.9 pKi = 6.9 Functional
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 623 11 3 6 3.7 CN1CCN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)Cc3ccccc3C2)CC1 10.1016/j.bmcl.2007.06.053
44434197 156005 0 None - 0 Guinea pig 7.7 pKi = 7.7 Functional
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 610 11 3 6 4.0 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCc2ccccc21)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
CHEMBL394419 156005 0 None - 0 Guinea pig 7.7 pKi = 7.7 Functional
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 610 11 3 6 4.0 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCc2ccccc21)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
10121831 96214 0 None - 0 Guinea pig 6.7 pKi = 6.7 Functional
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 618 17 3 5 6.5 CCCCN(CCCC)CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
CHEMBL237097 96214 0 None - 0 Guinea pig 6.7 pKi = 6.7 Functional
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 618 17 3 5 6.5 CCCCN(CCCC)CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
44434203 156006 0 None - 0 Guinea pig 6.7 pKi = 6.7 Functional
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 594 11 3 5 4.5 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCCC2)Cc2ccccc2C1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
CHEMBL394420 156006 0 None - 0 Guinea pig 6.7 pKi = 6.7 Functional
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 594 11 3 5 4.5 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCCC2)Cc2ccccc2C1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
44434191 156615 0 None - 0 Guinea pig 6.7 pKi = 6.7 Functional
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 588 11 3 5 5.4 CC1CCCCN1CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
CHEMBL394889 156615 0 None - 0 Guinea pig 6.7 pKi = 6.7 Functional
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 588 11 3 5 5.4 CC1CCCCN1CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
44434202 158949 0 None - 0 Guinea pig 6.7 pKi = 6.7 Functional
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 652 17 3 5 6.3 CCCCN(CCCC)CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)Cc2ccccc2C1 10.1016/j.bmcl.2007.06.053
CHEMBL396827 158949 0 None - 0 Guinea pig 6.7 pKi = 6.7 Functional
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 652 17 3 5 6.3 CCCCN(CCCC)CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)Cc2ccccc2C1 10.1016/j.bmcl.2007.06.053
10281234 99009 0 None - 0 Guinea pig 7.6 pKi = 7.6 Functional
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 562 11 3 6 3.5 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
CHEMBL242631 99009 0 None - 0 Guinea pig 7.6 pKi = 7.6 Functional
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 562 11 3 6 3.5 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
44434198 156602 0 None - 0 Guinea pig 7.6 pKi = 7.6 Functional
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 623 11 3 6 4.0 CN1CCN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCc3ccccc32)CC1 10.1016/j.bmcl.2007.06.053
CHEMBL394878 156602 0 None - 0 Guinea pig 7.6 pKi = 7.6 Functional
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 623 11 3 6 4.0 CN1CCN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCc3ccccc32)CC1 10.1016/j.bmcl.2007.06.053
3881 8635 0 None - 1 Rat 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1331460
2091 9571 0 None 223 2 Guinea pig 8.8 pEC50 = 8.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1311427
2089 9542 28 None -1 8 Guinea pig 8.9 pEC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2426129
3795 9542 28 None -1 8 Guinea pig 8.9 pEC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2426129
5311311 9542 28 None -1 8 Guinea pig 8.9 pEC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2426129
CHEMBL217406 9542 28 None -1 8 Guinea pig 8.9 pEC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2426129
16132172 9568 0 None - 1 Guinea pig 9.5 pEC50 = 9.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1311427
3667 9568 0 None - 1 Guinea pig 9.5 pEC50 = 9.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1311427
30699 224483 0 None -1 14 Human 8.3 pIC50 = 8.3 Functional
NoneNone
Drug Central 423 7 2 8 0.5 CC(=O)OCC1=C(N2[C@H](SC1)[C@H](NC(=O)CSC1=CC=NC=C1)C2=O)C(O)=O None
104974 10248 31 None 6 5 Guinea pig 10.3 pIC50 = 10.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 1334836
2111 10248 31 None 6 5 Guinea pig 10.3 pIC50 = 10.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 1334836
3481 10248 31 None 6 5 Guinea pig 10.3 pIC50 = 10.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 1334836
CHEMBL308148 10248 31 None 6 5 Guinea pig 10.3 pIC50 = 10.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 1334836
DB06660 10248 31 None 6 5 Guinea pig 10.3 pIC50 = 10.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 1334836
3843 9215 0 None - 1 Rat 9.1 pIC50 = 9.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9718274


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Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
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ity		 Common
name		 GPCRdb
ID		 #Vendors

 Reference
ligand		 Fold
selectivity		 # Tested
GPCRs		 Species

 p-value
(-log)		 Activity
Type		 Activity
Relation		 Activity
Value		 Assay
Type		 Assay
Description		 Source

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weight		 Rot
Bonds		 H don

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 DOI
1024 8072 71 None - 1 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human TACR2 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR2 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL None None None None 10.1038/s41467-023-40064-9
162639143 8072 71 None - 1 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human TACR2 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR2 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL None None None None 10.1038/s41467-023-40064-9
5284373 8072 71 None - 1 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human TACR2 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR2 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL None None None None 10.1038/s41467-023-40064-9
760 8072 71 None - 1 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human TACR2 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR2 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL None None None None 10.1038/s41467-023-40064-9
CHEMBL160 8072 71 None - 1 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human TACR2 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR2 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL None None None None 10.1038/s41467-023-40064-9
DB00091 8072 71 None - 1 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human TACR2 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR2 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL None None None None 10.1038/s41467-023-40064-9
CHEMBL3039583 217728 0 None - 0 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human TACR2 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR2 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL None None None NCCCC[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](c2ccccc2)NC(=O)[C@@H]2C[C@H](OC(=O)NCCN)CN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(OCc3ccccc3)cc2)NC1=O 10.1038/s41467-023-40064-9
124003 9264 22 None - 1 Human 7.1 pEC50 = 7.1 Binding
Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in CHO cellsDisplacement of [3H]SR48968 from human recombinant NK2 receptor expressed in CHO cells
ChEMBL None None None None 10.1021/np058114h
2116 9264 22 None - 1 Human 7.1 pEC50 = 7.1 Binding
Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in CHO cellsDisplacement of [3H]SR48968 from human recombinant NK2 receptor expressed in CHO cells
ChEMBL None None None None 10.1021/np058114h
CHEMBL507824 9264 22 None - 1 Human 7.1 pEC50 = 7.1 Binding
Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in CHO cellsDisplacement of [3H]SR48968 from human recombinant NK2 receptor expressed in CHO cells
ChEMBL None None None None 10.1021/np058114h
CHEMBL334721 218178 1 None - 3 Golden hamster 10.1 pIC50 = 10.1 Binding
Tested for binding affinity of compound against [125I]NKA binding to neurokinin-2 (NK-2) receptor in hamster urinary bladderTested for binding affinity of compound against [125I]NKA binding to neurokinin-2 (NK-2) receptor in hamster urinary bladder
ChEMBL None None None CSCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CNC(=O)C[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2 10.1016/S0960-894X(96)00570-7
104974 10248 31 None 1 7 Human 9.9 pIC50 = 9.9 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/s0960-894x(98)00395-3
2111 10248 31 None 1 7 Human 9.9 pIC50 = 9.9 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/s0960-894x(98)00395-3
3481 10248 31 None 1 7 Human 9.9 pIC50 = 9.9 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/s0960-894x(98)00395-3
CHEMBL308148 10248 31 None 1 7 Human 9.9 pIC50 = 9.9 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/s0960-894x(98)00395-3
DB06660 10248 31 None 1 7 Human 9.9 pIC50 = 9.9 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/s0960-894x(98)00395-3
68932311 131571 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 565 5 1 4 4.3 CN(C(=O)c1ccc(Cl)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
CHEMBL3642170 131571 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 565 5 1 4 4.3 CN(C(=O)c1ccc(Cl)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
68870199 131572 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 535 5 0 3 5.8 CC(=O)N1CCC(CN2CC[C@@H](N(C)C(=O)c3ccc(Cl)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642171 131572 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 535 5 0 3 5.8 CC(=O)N1CCC(CN2CC[C@@H](N(C)C(=O)c3ccc(Cl)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
68932793 131574 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 599 5 1 4 4.7 CN(C(=O)c1ccc(C(F)(F)F)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
CHEMBL3642173 131574 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 599 5 1 4 4.7 CN(C(=O)c1ccc(C(F)(F)F)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
68930433 131567 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 583 4 0 3 5.7 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(C(F)(F)F)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642166 131567 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 583 4 0 3 5.7 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(C(F)(F)F)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
68928720 131575 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 609 5 1 4 4.4 CN(C(=O)c1ccc(Br)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
CHEMBL3642174 131575 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 609 5 1 4 4.4 CN(C(=O)c1ccc(Br)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
68870858 131569 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 555 5 0 3 5.6 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(C4CC4)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642168 131569 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 555 5 0 3 5.6 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(C4CC4)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
68870105 131565 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 549 4 0 3 5.4 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Cl)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642164 131565 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 549 4 0 3 5.4 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Cl)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
68932418 131573 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 642 6 1 6 4.1 CN(C(=O)c1ccc(N2CCOCC2)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)C3(O)CC3)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
CHEMBL3642172 131573 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 642 6 1 6 4.1 CN(C(=O)c1ccc(N2CCOCC2)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)C3(O)CC3)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
68928842 131576 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 600 5 1 5 4.1 CN(C(=O)c1ccc(C(F)(F)F)cn1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
CHEMBL3642175 131576 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 600 5 1 5 4.1 CN(C(=O)c1ccc(C(F)(F)F)cn1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
9959481 71993 0 None - 1 Human 9.4 pIC50 = 9.4 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 559 7 0 3 6.2 O=C1CC[C@](CCN2CC(N3CCC(F)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCC(F)(F)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL182600 71993 0 None - 1 Human 9.4 pIC50 = 9.4 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 559 7 0 3 6.2 O=C1CC[C@](CCN2CC(N3CCC(F)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCC(F)(F)CC1 10.1016/j.bmcl.2005.05.134
68869786 131568 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 600 5 0 5 4.5 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(N4CCOCC4)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642167 131568 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 600 5 0 5 4.5 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(N4CCOCC4)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
104974 10248 31 None 1 7 Human 9.4 pIC50 = 9.4 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/0960-894X(96)00148-5
2111 10248 31 None 1 7 Human 9.4 pIC50 = 9.4 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/0960-894X(96)00148-5
3481 10248 31 None 1 7 Human 9.4 pIC50 = 9.4 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/0960-894X(96)00148-5
CHEMBL308148 10248 31 None 1 7 Human 9.4 pIC50 = 9.4 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/0960-894X(96)00148-5
DB06660 10248 31 None 1 7 Human 9.4 pIC50 = 9.4 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/0960-894X(96)00148-5
71699787 131558 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 593 4 0 3 5.5 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Br)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642157 131558 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 593 4 0 3 5.5 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Br)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 nan
693306 167208 57 None - 0 Human 9.3 pIC50 = 9.3 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 290 6 0 3 4.1 CCOc1cc(C=O)ccc1OCc1ccc(Cl)cc1 nan
CHEMBL4111499 167208 57 None - 0 Human 9.3 pIC50 = 9.3 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 290 6 0 3 4.1 CCOc1cc(C=O)ccc1OCc1ccc(Cl)cc1 nan
68932391 131566 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 545 5 0 4 4.7 COc1ccc(C(=O)N(C)[C@@H]2CCN(C(=O)C3CCN(C(C)=O)CC3)C[C@H]2c2ccc(Cl)c(Cl)c2)cc1 nan
CHEMBL3642165 131566 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 545 5 0 4 4.7 COc1ccc(C(=O)N(C)[C@@H]2CCN(C(=O)C3CCN(C(C)=O)CC3)C[C@H]2c2ccc(Cl)c(Cl)c2)cc1 nan
42611207 131564 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 651 4 0 3 6.7 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642163 131564 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 651 4 0 3 6.7 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
10929285 73483 0 None - 2 Human 9.1 pIC50 = 9.1 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 507 7 0 4 4.8 O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCCCC1 10.1016/j.bmcl.2005.05.134
CHEMBL185572 73483 0 None - 2 Human 9.1 pIC50 = 9.1 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 507 7 0 4 4.8 O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCCCC1 10.1016/j.bmcl.2005.05.134
104974 10248 31 None 1 7 Human 9.1 pIC50 = 9.1 Binding
Binding affinity was determined against human NK2 receptor in CHO cells using [125I]neurokinin A as radioligandBinding affinity was determined against human NK2 receptor in CHO cells using [125I]neurokinin A as radioligand
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/0960-894X(96)00075-3
2111 10248 31 None 1 7 Human 9.1 pIC50 = 9.1 Binding
Binding affinity was determined against human NK2 receptor in CHO cells using [125I]neurokinin A as radioligandBinding affinity was determined against human NK2 receptor in CHO cells using [125I]neurokinin A as radioligand
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/0960-894X(96)00075-3
3481 10248 31 None 1 7 Human 9.1 pIC50 = 9.1 Binding
Binding affinity was determined against human NK2 receptor in CHO cells using [125I]neurokinin A as radioligandBinding affinity was determined against human NK2 receptor in CHO cells using [125I]neurokinin A as radioligand
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/0960-894X(96)00075-3
CHEMBL308148 10248 31 None 1 7 Human 9.1 pIC50 = 9.1 Binding
Binding affinity was determined against human NK2 receptor in CHO cells using [125I]neurokinin A as radioligandBinding affinity was determined against human NK2 receptor in CHO cells using [125I]neurokinin A as radioligand
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/0960-894X(96)00075-3
DB06660 10248 31 None 1 7 Human 9.1 pIC50 = 9.1 Binding
Binding affinity was determined against human NK2 receptor in CHO cells using [125I]neurokinin A as radioligandBinding affinity was determined against human NK2 receptor in CHO cells using [125I]neurokinin A as radioligand
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/0960-894X(96)00075-3
68932301 131570 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 594 4 0 4 4.9 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Br)cn3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642169 131570 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 594 4 0 4 4.9 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Br)cn3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
2089 9542 28 None - 5 Golden hamster 9.0 pIC50 = 9 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm00099a024
3795 9542 28 None - 5 Golden hamster 9.0 pIC50 = 9 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm00099a024
5311311 9542 28 None - 5 Golden hamster 9.0 pIC50 = 9 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm00099a024
CHEMBL217406 9542 28 None - 5 Golden hamster 9.0 pIC50 = 9 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm00099a024
10033398 124070 0 None - 0 Golden hamster 9.0 pIC50 = 9 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 824 27 9 10 -0.0 CCCN(C[C@H](CC(C)C)NC(=O)CCNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00099a024
CHEMBL339591 124070 0 None - 0 Golden hamster 9.0 pIC50 = 9 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 824 27 9 10 -0.0 CCCN(C[C@H](CC(C)C)NC(=O)CCNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00099a024
44392491 175089 0 None - 1 Human 9.0 pIC50 = 9 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 556 7 1 4 5.2 NC1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CCC(F)(F)CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL434142 175089 0 None - 1 Human 9.0 pIC50 = 9 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 556 7 1 4 5.2 NC1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CCC(F)(F)CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
71699790 131561 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 549 4 0 3 5.4 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Cl)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642160 131561 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 549 4 0 3 5.4 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Cl)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 nan
72548703 168346 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]NKA from human recombinant NK2 receptor after 60 mins by scintillation counting analysisDisplacement of [125I]NKA from human recombinant NK2 receptor after 60 mins by scintillation counting analysis
ChEMBL 583 8 3 6 5.8 CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 10.1016/j.bmcl.2018.03.093
CHEMBL4128926 168346 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]NKA from human recombinant NK2 receptor after 60 mins by scintillation counting analysisDisplacement of [125I]NKA from human recombinant NK2 receptor after 60 mins by scintillation counting analysis
ChEMBL 583 8 3 6 5.8 CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 10.1016/j.bmcl.2018.03.093
44392351 73176 0 None - 1 Human 8.9 pIC50 = 8.9 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 620 8 0 5 4.3 CS(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CCC(F)(F)CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL185182 73176 0 None - 1 Human 8.9 pIC50 = 8.9 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 620 8 0 5 4.3 CS(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CCC(F)(F)CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
44392439 175154 0 None - 1 Human 8.9 pIC50 = 8.9 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 557 7 1 4 5.2 O=C1CC[C@](CCN2CC(N3CCC(O)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCC(F)(F)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL434548 175154 0 None - 1 Human 8.9 pIC50 = 8.9 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 557 7 1 4 5.2 O=C1CC[C@](CCN2CC(N3CCC(O)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCC(F)(F)CC1 10.1016/j.bmcl.2005.05.134
2089 9542 28 None 102 5 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
3795 9542 28 None 102 5 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
5311311 9542 28 None 102 5 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
CHEMBL217406 9542 28 None 102 5 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
71699791 131562 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 591 5 0 3 6.4 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(-c4ccccc4)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642161 131562 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 591 5 0 3 6.4 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(-c4ccccc4)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 nan
10327914 24863 0 None - 0 Golden hamster 8.0 pIC50 = 8 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 782 25 10 10 -1.1 CC(C)C[C@@H](CN[C@@H](Cc1ccccc1)C(N)=O)NC(=O)CCNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C 10.1021/jm00099a024
CHEMBL126776 24863 0 None - 0 Golden hamster 8.0 pIC50 = 8 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 782 25 10 10 -1.1 CC(C)C[C@@H](CN[C@@H](Cc1ccccc1)C(N)=O)NC(=O)CCNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C 10.1021/jm00099a024
44392444 129112 0 None - 1 Human 8.0 pIC50 = 8 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 481 7 0 3 4.8 O=C1CC[C@](CCN2CC(N3CCC(F)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1 10.1016/j.bmcl.2005.05.134
CHEMBL359903 129112 0 None - 1 Human 8.0 pIC50 = 8 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 481 7 0 3 4.8 O=C1CC[C@](CCN2CC(N3CCC(F)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1 10.1016/j.bmcl.2005.05.134
44319321 20476 0 None - 0 Mouse 8.0 pIC50 = 8.0 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccncc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL1194933 20476 0 None - 0 Mouse 8.0 pIC50 = 8.0 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccncc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL553554 20476 0 None - 0 Mouse 8.0 pIC50 = 8.0 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccncc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
73265452 133223 0 None - 0 Human 7.0 pIC50 = 7 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 609 4 0 4 5.8 CN(C(=O)N(C)[C@@H]1CCN(C2CCS(=O)(=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL3651890 133223 0 None - 0 Human 7.0 pIC50 = 7 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 609 4 0 4 5.8 CN(C(=O)N(C)[C@@H]1CCN(C2CCS(=O)(=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
91535935 165398 0 None - 0 Human 7.0 pIC50 = 7 Binding
Inhibition of NK2 receptor (unknown origin) by FLIPR assayInhibition of NK2 receptor (unknown origin) by FLIPR assay
ChEMBL 532 7 1 4 6.8 C[C@H](NC(=O)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/acsmedchemlett.7b00094
CHEMBL4092276 165398 0 None - 0 Human 7.0 pIC50 = 7 Binding
Inhibition of NK2 receptor (unknown origin) by FLIPR assayInhibition of NK2 receptor (unknown origin) by FLIPR assay
ChEMBL 532 7 1 4 6.8 C[C@H](NC(=O)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/acsmedchemlett.7b00094
44411742 85078 0 None - 0 Human 6.0 pIC50 = 6 Binding
Inhibition of human NK2 receptor expressed in CHO cellsInhibition of human NK2 receptor expressed in CHO cells
ChEMBL 441 4 1 3 4.5 O=C(CC1CCN(C(=O)c2cccc(C#Cc3ccccn3)c2)CC1)Nc1ccc(F)cc1 10.1016/j.bmcl.2006.02.027
CHEMBL210811 85078 0 None - 0 Human 6.0 pIC50 = 6 Binding
Inhibition of human NK2 receptor expressed in CHO cellsInhibition of human NK2 receptor expressed in CHO cells
ChEMBL 441 4 1 3 4.5 O=C(CC1CCN(C(=O)c2cccc(C#Cc3ccccn3)c2)CC1)Nc1ccc(F)cc1 10.1016/j.bmcl.2006.02.027
2812 11551 101 None -28 34 Human 5.0 pIC50 = 5.0 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 nan
CHEMBL104 11551 101 None -28 34 Human 5.0 pIC50 = 5.0 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 nan
2090 9543 25 None -38 4 Human 7.0 pIC50 = 7.0 Binding
Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
5311312 9543 25 None -38 4 Human 7.0 pIC50 = 7.0 Binding
Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
CHEMBL437797 9543 25 None -38 4 Human 7.0 pIC50 = 7.0 Binding
Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
10010429 25814 0 None - 0 Golden hamster 7.0 pIC50 = 7.0 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 776 26 9 10 -0.6 CCCN(C[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)[C@@H](CC(C)C)C(N)=O 10.1021/jm00099a024
CHEMBL128854 25814 0 None - 0 Golden hamster 7.0 pIC50 = 7.0 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 776 26 9 10 -0.6 CCCN(C[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)[C@@H](CC(C)C)C(N)=O 10.1021/jm00099a024
49863734 22105 0 None -13 4 Rat 7.0 pIC50 = 7.0 Binding
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 1477 21 11 14 6.8 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm100157m
CHEMBL1214027 22105 0 None -13 4 Rat 7.0 pIC50 = 7.0 Binding
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 1477 21 11 14 6.8 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm100157m
CHEMBL103634 215237 0 None - 1 Human 7.0 pIC50 = 7.0 Binding
Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2
ChEMBL None None None CC(C)CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(C)C)C(N)=O 10.1021/jm9807151
44305248 209666 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 585 8 1 3 7.0 CN(C)CCCNC(=O)c1ccc(-c2ccc(Cl)cc2)c(N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1 10.1016/s0960-894x(02)00382-7
CHEMBL62679 209666 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 585 8 1 3 7.0 CN(C)CCCNC(=O)c1ccc(-c2ccc(Cl)cc2)c(N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1 10.1016/s0960-894x(02)00382-7
10485206 124955 0 None - 0 Golden hamster 7.0 pIC50 = 7.0 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 748 25 10 10 -1.3 CC(C)C[C@@H](CN[C@@H](CC(C)C)C(N)=O)NC(=O)CCNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C 10.1021/jm00099a024
CHEMBL340880 124955 0 None - 0 Golden hamster 7.0 pIC50 = 7.0 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 748 25 10 10 -1.3 CC(C)C[C@@H](CN[C@@H](CC(C)C)C(N)=O)NC(=O)CCNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C 10.1021/jm00099a024
44384901 176683 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 579 8 1 4 5.7 COc1ccc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1 10.1016/0960-894X(96)00148-5
CHEMBL444086 176683 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 579 8 1 4 5.7 COc1ccc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1 10.1016/0960-894X(96)00148-5
44319082 174806 0 None - 0 Mouse 7.9 pIC50 = 7.9 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 752 13 1 8 5.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)NCCN4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL432183 174806 0 None - 0 Mouse 7.9 pIC50 = 7.9 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 752 13 1 8 5.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)NCCN4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL2372521 217048 0 None - 0 Rat 7.0 pIC50 = 7.0 Binding
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1CCc2ccccc21)C1c2ccccc2-c2ccccc21)C(N)=O 10.1021/jm00037a009
10435115 127577 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligandBinding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand
ChEMBL 476 7 2 3 5.2 [O-][S+](c1ccccc1)C(c1ccccc1)C1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1 10.1016/s0960-894x(01)00074-9
CHEMBL355541 127577 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligandBinding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand
ChEMBL 476 7 2 3 5.2 [O-][S+](c1ccccc1)C(c1ccccc1)C1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1 10.1016/s0960-894x(01)00074-9
9940218 125116 2 None - 0 Golden hamster 6.9 pIC50 = 6.9 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 734 24 10 10 -1.7 CC(C)C[C@@H](CN[C@@H](CC(C)C)C(N)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C 10.1021/jm00099a024
CHEMBL341015 125116 2 None - 0 Golden hamster 6.9 pIC50 = 6.9 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 734 24 10 10 -1.7 CC(C)C[C@@H](CN[C@@H](CC(C)C)C(N)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C 10.1021/jm00099a024
67232184 133224 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 548 4 0 3 4.9 CC(=O)N1CCC(C(=O)N2C[C@@H](N(C)C(=O)N(C)c3cc(Cl)cc(Cl)c3)[C@H](c3ccc(F)cc3)C2)CC1 nan
CHEMBL3651891 133224 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 548 4 0 3 4.9 CC(=O)N1CCC(C(=O)N2C[C@@H](N(C)C(=O)N(C)c3cc(Cl)cc(Cl)c3)[C@H](c3ccc(F)cc3)C2)CC1 nan
44384902 66721 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 579 8 1 4 5.7 COc1cccc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/0960-894X(96)00148-5
CHEMBL173245 66721 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 579 8 1 4 5.7 COc1cccc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/0960-894X(96)00148-5
44319222 112920 0 None - 0 Mouse 7.9 pIC50 = 7.9 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 657 10 1 6 5.9 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL313546 112920 0 None - 0 Mouse 7.9 pIC50 = 7.9 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 657 10 1 6 5.9 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
73265453 133225 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 617 4 0 4 5.0 CC(=O)N1CCC(C(=O)N2CC(c3ccc(F)cn3)[C@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
CHEMBL3651892 133225 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 617 4 0 4 5.0 CC(=O)N1CCC(C(=O)N2CC(c3ccc(F)cn3)[C@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
CHEMBL2372519 217047 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1CCc2cc3ccccc3cc21)C(N)=O 10.1021/jm00037a009
71458131 86459 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
CHEMBL2115343 86459 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
71452663 85317 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
CHEMBL2112070 85317 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
2750 210840 76 None -2 12 Human 4.9 pIC50 = 4.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 333 5 1 4 3.9 CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1 nan
CHEMBL7002 210840 76 None -2 12 Human 4.9 pIC50 = 4.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 333 5 1 4 3.9 CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1 nan
9832198 113532 0 None - 3 Human 6.9 pIC50 = 6.9 Binding
Tested for binding affinity against human NK-2 receptorTested for binding affinity against human NK-2 receptor
ChEMBL 788 15 4 8 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCC(=O)O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144351 113532 0 None - 3 Human 6.9 pIC50 = 6.9 Binding
Tested for binding affinity against human NK-2 receptorTested for binding affinity against human NK-2 receptor
ChEMBL 788 15 4 8 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCC(=O)O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44384986 136552 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 623 9 1 5 6.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1C 10.1016/0960-894X(96)00148-5
CHEMBL367528 136552 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 623 9 1 5 6.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1C 10.1016/0960-894X(96)00148-5
10366515 64352 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligandBinding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand
ChEMBL 450 6 2 3 4.6 [O-][S+](CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1)c1ccc2ccccc2c1 10.1016/s0960-894x(01)00074-9
CHEMBL166675 64352 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligandBinding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand
ChEMBL 450 6 2 3 4.6 [O-][S+](CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1)c1ccc2ccccc2c1 10.1016/s0960-894x(01)00074-9
CHEMBL2372516 217044 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1c2ccccc2-c2ccccc21)C(N)=O 10.1021/jm00037a009
137647980 164716 3 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of NK2 receptor (unknown origin) by FLIPR assayInhibition of NK2 receptor (unknown origin) by FLIPR assay
ChEMBL 600 7 1 4 7.9 C[C@H](NC(=O)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2cccc(C(F)(F)F)c2)nc2ccccc12)c1ccccc1 10.1021/acsmedchemlett.7b00094
CHEMBL4084542 164716 3 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of NK2 receptor (unknown origin) by FLIPR assayInhibition of NK2 receptor (unknown origin) by FLIPR assay
ChEMBL 600 7 1 4 7.9 C[C@H](NC(=O)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2cccc(C(F)(F)F)c2)nc2ccccc12)c1ccccc1 10.1021/acsmedchemlett.7b00094
CHEMBL341065 218418 0 None - 0 Golden hamster 6.9 pIC50 = 6.9 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(N)=O 10.1021/jm00099a024
CHEMBL449091 220739 0 None - 0 Golden hamster 5.9 pIC50 = 5.9 Binding
Concentration producing half-maximal inhibition of specific binding of. [125I]neurokinin A to NK-2 receptors in the hamster urinary bladderConcentration producing half-maximal inhibition of specific binding of. [125I]neurokinin A to NK-2 receptors in the hamster urinary bladder
ChEMBL None None None C/C=C/CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(C)=O)C(N)=O 10.1016/0960-894X(94)85022-4
44312324 211463 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 534 7 2 2 5.8 CCN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
CHEMBL73896 211463 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 534 7 2 2 5.8 CCN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
44312219 109158 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 506 6 3 2 5.1 O=C(NCc1ccccc1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
CHEMBL303868 109158 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 506 6 3 2 5.1 O=C(NCc1ccccc1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
44380176 168288 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligandBinding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand
ChEMBL 613 10 1 3 7.7 CN(C[C@@H](CCN1CCC(NC(=O)c2ccccc2)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(01)00074-9
CHEMBL412815 168288 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligandBinding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand
ChEMBL 613 10 1 3 7.7 CN(C[C@@H](CCN1CCC(NC(=O)c2ccccc2)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(01)00074-9
44312056 211502 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 595 7 2 4 6.2 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3cc(C)cc(C)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
CHEMBL74237 211502 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 595 7 2 4 6.2 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3cc(C)cc(C)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
10349900 113526 0 None - 3 Rat 6.9 pIC50 = 6.9 Binding
Tested for binding affinity against rat NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for binding affinity against rat NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligand
ChEMBL 716 13 3 7 2.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144343 113526 0 None - 3 Rat 6.9 pIC50 = 6.9 Binding
Tested for binding affinity against rat NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for binding affinity against rat NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligand
ChEMBL 716 13 3 7 2.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
6518171 175075 55 None -4 8 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 495 12 2 6 4.9 CN(CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(=O)O)cc1)c1ccccn1 nan
CHEMBL434063 175075 55 None -4 8 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 495 12 2 6 4.9 CN(CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(=O)O)cc1)c1ccccn1 nan
3561 25849 39 None -1 11 Human 5.8 pIC50 = 5.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 360 2 0 1 4.4 Clc1cc(Cl)c(OCC#CI)cc1Cl nan
CHEMBL1289 25849 39 None -1 11 Human 5.8 pIC50 = 5.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 360 2 0 1 4.4 Clc1cc(Cl)c(OCC#CI)cc1Cl nan
2098 10466 36 None - 6 Golden hamster 6.8 pIC50 = 6.8 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm00099a024
36511 10466 36 None - 6 Golden hamster 6.8 pIC50 = 6.8 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm00099a024
3805 10466 36 None - 6 Golden hamster 6.8 pIC50 = 6.8 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm00099a024
3835 10466 36 None - 6 Golden hamster 6.8 pIC50 = 6.8 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm00099a024
CHEMBL235363 10466 36 None - 6 Golden hamster 6.8 pIC50 = 6.8 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm00099a024
11038500 70327 0 None - 1 Human 7.8 pIC50 = 7.8 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 507 9 0 4 4.8 CCOC1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL180049 70327 0 None - 1 Human 7.8 pIC50 = 7.8 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 507 9 0 4 4.8 CCOC1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
10940813 73105 0 None - 1 Human 7.8 pIC50 = 7.8 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 571 9 0 5 2.8 CN(C)S(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL185007 73105 0 None - 1 Human 7.8 pIC50 = 7.8 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 571 9 0 5 2.8 CN(C)S(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
9914897 185837 0 None - 0 Golden hamster 5.8 pIC50 = 5.8 Binding
Compound was tested for binding affinity towards Tachykinin receptor 2 binding sites in membranes prepared from hamster urinary bladder using [125I]neurokinin A as radioligandCompound was tested for binding affinity towards Tachykinin receptor 2 binding sites in membranes prepared from hamster urinary bladder using [125I]neurokinin A as radioligand
ChEMBL 528 15 4 4 5.0 CC(C)[C@H](OC(=O)N[C@](C)(Cc1ccccc1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 10.1016/0960-894X(95)00313-I
CHEMBL47146 185837 0 None - 0 Golden hamster 5.8 pIC50 = 5.8 Binding
Compound was tested for binding affinity towards Tachykinin receptor 2 binding sites in membranes prepared from hamster urinary bladder using [125I]neurokinin A as radioligandCompound was tested for binding affinity towards Tachykinin receptor 2 binding sites in membranes prepared from hamster urinary bladder using [125I]neurokinin A as radioligand
ChEMBL 528 15 4 4 5.0 CC(C)[C@H](OC(=O)N[C@](C)(Cc1ccccc1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 10.1016/0960-894X(95)00313-I
9914897 185837 0 None - 0 Golden hamster 5.8 pIC50 = 5.8 Binding
Inhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKAInhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKA
ChEMBL 528 15 4 4 5.0 CC(C)[C@H](OC(=O)N[C@](C)(Cc1ccccc1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 10.1021/jm950892r
CHEMBL47146 185837 0 None - 0 Golden hamster 5.8 pIC50 = 5.8 Binding
Inhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKAInhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKA
ChEMBL 528 15 4 4 5.0 CC(C)[C@H](OC(=O)N[C@](C)(Cc1ccccc1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 10.1021/jm950892r
148124 213878 86 None - 1 Human 5.8 pIC50 = 5.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 807 8 5 14 3.3 CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@@H]12)C3(C)C nan
CHEMBL3545252 213878 86 None - 1 Human 5.8 pIC50 = 5.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 807 8 5 14 3.3 CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@@H]12)C3(C)C nan
CHEMBL92 213878 86 None - 1 Human 5.8 pIC50 = 5.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 807 8 5 14 3.3 CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@@H]12)C3(C)C nan
44319307 113324 0 None - 0 Mouse 7.8 pIC50 = 7.8 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL314119 113324 0 None - 0 Mouse 7.8 pIC50 = 7.8 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
44319306 113874 0 None - 0 Mouse 7.8 pIC50 = 7.8 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccncc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL315923 113874 0 None - 0 Mouse 7.8 pIC50 = 7.8 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccncc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
44212282 68061 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 579 8 1 4 5.7 COc1ccccc1C(=O)N1CCC(CCN2CCC(C(N)=O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/0960-894X(96)00148-5
CHEMBL176682 68061 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 579 8 1 4 5.7 COc1ccccc1C(=O)N1CCC(CCN2CCC(C(N)=O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/0960-894X(96)00148-5
CHEMBL276294 217607 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(C)(C)S(C)(=O)=O)C(N)=O 10.1021/jm00037a009
138106918 202265 42 None - 1 Human 5.8 pIC50 = 5.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 778 7 2 11 4.8 CCC1=C[C@@H]2CN(C1)Cc1c([nH]c3ccccc13)[C@@](C(=O)OC)(c1cc3c(cc1OC)N(C)[C@H]1[C@@](O)(C(=O)OC)[C@H](OC(C)=O)[C@]4(CC)C=CCN5CC[C@]31[C@@H]54)C2 nan
5311497 202265 42 None - 1 Human 5.8 pIC50 = 5.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 778 7 2 11 4.8 CCC1=C[C@@H]2CN(C1)Cc1c([nH]c3ccccc13)[C@@](C(=O)OC)(c1cc3c(cc1OC)N(C)[C@H]1[C@@](O)(C(=O)OC)[C@H](OC(C)=O)[C@]4(CC)C=CCN5CC[C@]31[C@@H]54)C2 nan
CHEMBL553025 202265 42 None - 1 Human 5.8 pIC50 = 5.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 778 7 2 11 4.8 CCC1=C[C@@H]2CN(C1)Cc1c([nH]c3ccccc13)[C@@](C(=O)OC)(c1cc3c(cc1OC)N(C)[C@H]1[C@@](O)(C(=O)OC)[C@H](OC(C)=O)[C@]4(CC)C=CCN5CC[C@]31[C@@H]54)C2 nan
6918276 22383 7 None -56 8 Human 5.8 pIC50 = 5.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 559 18 4 9 1.7 CC[C@H](C)[C@@H](CO[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCS(C)(=O)=O)C(=O)OC(C)C)NC[C@@H](N)CS nan
CHEMBL1221512 22383 7 None -56 8 Human 5.8 pIC50 = 5.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 559 18 4 9 1.7 CC[C@H](C)[C@@H](CO[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCS(C)(=O)=O)C(=O)OC(C)C)NC[C@@H](N)CS nan
CHEMBL306072 217756 0 None - 0 Golden hamster 5.8 pIC50 = 5.8 Binding
Concentration producing half-maximal inhibition of specific binding of. [125I]neurokinin A to NK-2 receptors in the hamster urinary bladderConcentration producing half-maximal inhibition of specific binding of. [125I]neurokinin A to NK-2 receptors in the hamster urinary bladder
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(C)=O)C(N)=O 10.1016/0960-894X(94)85022-4
71456198 85350 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 565 8 2 6 4.7 COc1cc(C(=O)N(C)c2cc(C(=O)N[C@@H]3CCCCNC3=O)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC 10.1016/s0960-894x(02)00382-7
CHEMBL2112209 85350 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 565 8 2 6 4.7 COc1cc(C(=O)N(C)c2cc(C(=O)N[C@@H]3CCCCNC3=O)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC 10.1016/s0960-894x(02)00382-7
44351724 26169 0 None - 0 Golden hamster 6.8 pIC50 = 6.8 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 818 26 9 10 -0.4 CC(C)CC(=O)N(C[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)[C@@H](CC(C)C)C(N)=O 10.1021/jm00099a024
CHEMBL129301 26169 0 None - 0 Golden hamster 6.8 pIC50 = 6.8 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 818 26 9 10 -0.4 CC(C)CC(=O)N(C[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)[C@@H](CC(C)C)C(N)=O 10.1021/jm00099a024
CHEMBL340847 218415 0 None - 0 Golden hamster 5.8 pIC50 = 5.8 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NCCCC(=O)O)C(C)C)C(N)=O 10.1021/jm00099a024
44312218 210919 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 542 8 1 4 5.5 CSN1CC2(CCN(C(=O)N[C@@H](CCc3ccccc3)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
CHEMBL70461 210919 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 542 8 1 4 5.5 CSN1CC2(CCN(C(=O)N[C@@H](CCc3ccccc3)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
11057 182928 23 None -1 20 Human 5.8 pIC50 = 5.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 nan
3468 182928 23 None -1 20 Human 5.8 pIC50 = 5.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 nan
CHEMBL459265 182928 23 None -1 20 Human 5.8 pIC50 = 5.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 nan
CHEMBL64894 182928 23 None -1 20 Human 5.8 pIC50 = 5.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 nan
44305511 209745 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 566 5 1 2 7.9 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)NC2CCCCC2)ccc1-c1ccc(F)cc1 10.1016/s0960-894x(02)00382-7
CHEMBL63014 209745 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 566 5 1 2 7.9 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)NC2CCCCC2)ccc1-c1ccc(F)cc1 10.1016/s0960-894x(02)00382-7
44335354 11706 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 629 7 2 4 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1cc(Cl)c(Cl)s1 10.1016/s0960-894x(01)00631-x
CHEMBL104708 11706 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 629 7 2 4 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1cc(Cl)c(Cl)s1 10.1016/s0960-894x(01)00631-x
10349900 113526 0 None - 3 Human 7.8 pIC50 = 7.8 Binding
Tested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligand
ChEMBL 716 13 3 7 2.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144343 113526 0 None - 3 Human 7.8 pIC50 = 7.8 Binding
Tested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligand
ChEMBL 716 13 3 7 2.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44319223 113882 0 None - 0 Mouse 7.8 pIC50 = 7.8 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 669 11 1 7 5.7 COc1cccc(C2(C(N)=O)CCN(CCC3(c4ccc(Cl)c(Cl)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)c1 10.1016/S0960-894X(97)10013-0
CHEMBL315982 113882 0 None - 0 Mouse 7.8 pIC50 = 7.8 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 669 11 1 7 5.7 COc1cccc(C2(C(N)=O)CCN(CCC3(c4ccc(Cl)c(Cl)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)c1 10.1016/S0960-894X(97)10013-0
22901331 18753 0 None - 1 Rat 5.8 pIC50 = 5.8 Binding
Binding affinity of compound was evaluated towards tachykinin receptor 2 by using radioligand ([125I]-NKA in rat duodenumBinding affinity of compound was evaluated towards tachykinin receptor 2 by using radioligand ([125I]-NKA in rat duodenum
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
54435601 18753 0 None - 1 Rat 5.8 pIC50 = 5.8 Binding
Binding affinity of compound was evaluated towards tachykinin receptor 2 by using radioligand ([125I]-NKA in rat duodenumBinding affinity of compound was evaluated towards tachykinin receptor 2 by using radioligand ([125I]-NKA in rat duodenum
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
59922977 18753 0 None - 1 Rat 5.8 pIC50 = 5.8 Binding
Binding affinity of compound was evaluated towards tachykinin receptor 2 by using radioligand ([125I]-NKA in rat duodenumBinding affinity of compound was evaluated towards tachykinin receptor 2 by using radioligand ([125I]-NKA in rat duodenum
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL1183068 18753 0 None - 1 Rat 5.8 pIC50 = 5.8 Binding
Binding affinity of compound was evaluated towards tachykinin receptor 2 by using radioligand ([125I]-NKA in rat duodenumBinding affinity of compound was evaluated towards tachykinin receptor 2 by using radioligand ([125I]-NKA in rat duodenum
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL278294 18753 0 None - 1 Rat 5.8 pIC50 = 5.8 Binding
Binding affinity of compound was evaluated towards tachykinin receptor 2 by using radioligand ([125I]-NKA in rat duodenumBinding affinity of compound was evaluated towards tachykinin receptor 2 by using radioligand ([125I]-NKA in rat duodenum
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL406812 219400 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1Cc2ccccc2C1)C(N)=O 10.1021/jm00037a009
3823 56995 42 None -36 11 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 530 7 0 7 4.2 CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 nan
76973198 56995 42 None -36 11 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 530 7 0 7 4.2 CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 nan
CHEMBL157101 56995 42 None -36 11 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 530 7 0 7 4.2 CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 nan
44444681 101148 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity to NK2 receptorBinding affinity to NK2 receptor
ChEMBL 501 5 0 3 6.7 C[C@@H](O[C@@H]1CN(C2=CC(=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL250798 101148 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity to NK2 receptorBinding affinity to NK2 receptor
ChEMBL 501 5 0 3 6.7 C[C@@H](O[C@@H]1CN(C2=CC(=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
15730 77893 80 None -2 10 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 206 7 1 1 4.3 CCCCCCCCc1ccc(O)cc1 nan
CHEMBL195437 77893 80 None -2 10 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 206 7 1 1 4.3 CCCCCCCCc1ccc(O)cc1 nan
10258592 105983 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor
ChEMBL 639 7 0 4 6.8 CS(=O)(=O)N1CC2(CCN(CCCC3(c4ccc(Cl)c(Cl)c4)CCCN(C(=O)c4ccccc4)C3)CC2)c2ccccc21 10.1016/s0960-894x(98)00215-7
CHEMBL281481 105983 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor
ChEMBL 639 7 0 4 6.8 CS(=O)(=O)N1CC2(CCN(CCCC3(c4ccc(Cl)c(Cl)c4)CCCN(C(=O)c4ccccc4)C3)CC2)c2ccccc21 10.1016/s0960-894x(98)00215-7
2090 9543 25 None - 4 Golden hamster 7.8 pIC50 = 7.8 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm00099a024
5311312 9543 25 None - 4 Golden hamster 7.8 pIC50 = 7.8 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm00099a024
CHEMBL437797 9543 25 None - 4 Golden hamster 7.8 pIC50 = 7.8 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm00099a024
15391369 109605 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 518 6 2 2 5.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(C=Cc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
CHEMBL305509 109605 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 518 6 2 2 5.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(C=Cc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
49863732 22103 0 None -24 4 Rat 7.7 pIC50 = 7.7 Binding
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 1266 18 10 12 6.1 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
CHEMBL1214025 22103 0 None -24 4 Rat 7.7 pIC50 = 7.7 Binding
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 1266 18 10 12 6.1 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
9874168 212483 4 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/0960-894X(96)00148-5
CHEMBL82386 212483 4 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/0960-894X(96)00148-5
CHEMBL2372525 217049 0 None - 0 Rat 4.8 pIC50 = 4.8 Binding
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O 10.1021/jm00037a009
71452678 85352 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 591 5 2 3 6.4 Cc1ccc(-c2ccc(C(=O)N[C@@H]3CCCCNC3=O)cc2N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 10.1016/s0960-894x(02)00382-7
CHEMBL2112211 85352 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 591 5 2 3 6.4 Cc1ccc(-c2ccc(C(=O)N[C@@H]3CCCCNC3=O)cc2N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 10.1016/s0960-894x(02)00382-7
10350454 113508 0 None - 3 Rat 6.7 pIC50 = 6.7 Binding
Tested for binding affinity against rat NK-2 receptorTested for binding affinity against rat NK-2 receptor
ChEMBL 815 18 4 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144209 113508 0 None - 3 Rat 6.7 pIC50 = 6.7 Binding
Tested for binding affinity against rat NK-2 receptorTested for binding affinity against rat NK-2 receptor
ChEMBL 815 18 4 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44384987 68128 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 609 9 1 5 5.7 COc1cc(OC)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/0960-894X(96)00148-5
CHEMBL176769 68128 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 609 9 1 5 5.7 COc1cc(OC)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/0960-894X(96)00148-5
44335466 11826 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 720 8 2 5 6.0 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(CCC(=O)N[C@@H]1CCCCNC1=O)Cc1cc(Br)c(Br)s1 10.1016/s0960-894x(01)00631-x
CHEMBL105295 11826 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 720 8 2 5 6.0 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(CCC(=O)N[C@@H]1CCCCNC1=O)Cc1cc(Br)c(Br)s1 10.1016/s0960-894x(01)00631-x
44319057 212623 0 None - 0 Mouse 6.7 pIC50 = 6.7 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 605 10 1 6 5.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3cccc(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL83585 212623 0 None - 0 Mouse 6.7 pIC50 = 6.7 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 605 10 1 6 5.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3cccc(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL415600 219973 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O 10.1021/jm00037a009
2335 18620 22 None -3 12 Human 5.7 pIC50 = 5.7 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 nan
8478 18620 22 None -3 12 Human 5.7 pIC50 = 5.7 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 nan
CHEMBL1182210 18620 22 None -3 12 Human 5.7 pIC50 = 5.7 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 nan
CHEMBL221753 18620 22 None -3 12 Human 5.7 pIC50 = 5.7 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 nan
10395276 25691 0 None - 0 Golden hamster 6.7 pIC50 = 6.7 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 748 24 9 10 -1.4 CC(C)C[C@@H](CN(C)[C@@H](CC(C)C)C(N)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C 10.1021/jm00099a024
CHEMBL128521 25691 0 None - 0 Golden hamster 6.7 pIC50 = 6.7 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 748 24 9 10 -1.4 CC(C)C[C@@H](CN(C)[C@@H](CC(C)C)C(N)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C 10.1021/jm00099a024
176 7186 66 None -4 31 Human 4.7 pIC50 = 4.7 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
2157 7186 66 None -4 31 Human 4.7 pIC50 = 4.7 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
2566 7186 66 None -4 31 Human 4.7 pIC50 = 4.7 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
CHEMBL633 7186 66 None -4 31 Human 4.7 pIC50 = 4.7 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
DB01118 7186 66 None -4 31 Human 4.7 pIC50 = 4.7 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
3191 109635 97 None -12 25 Human 5.7 pIC50 = 5.7 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 469 9 0 3 7.2 CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 nan
CHEMBL305660 109635 97 None -12 25 Human 5.7 pIC50 = 5.7 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 469 9 0 3 7.2 CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 nan
CHEMBL36402 218700 0 None - 0 Golden hamster 4.7 pIC50 = 4.7 Binding
Binding affinity towards Tachykinin receptor 2 using [125I]iodohistidyl-NKA (0.1 nM)) as radioligandBinding affinity towards Tachykinin receptor 2 using [125I]iodohistidyl-NKA (0.1 nM)) as radioligand
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(C)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O 10.1016/0960-894X(95)00254-Q
73265451 133222 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 666 4 0 3 6.8 CC(=O)N1CCC(C(=O)N2CC(c3ccc(Cl)c(Cl)c3)[C@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
CHEMBL3651889 133222 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 666 4 0 3 6.8 CC(=O)N1CCC(C(=O)N2CC(c3ccc(Cl)c(Cl)c3)[C@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
71699789 131560 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 529 4 0 3 5.0 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(C)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642159 131560 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 529 4 0 3 5.0 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(C)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 nan
9853506 19861 0 None - 0 Mouse 8.7 pIC50 = 8.7 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 709 10 0 7 6.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL1190281 19861 0 None - 0 Mouse 8.7 pIC50 = 8.7 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 709 10 0 7 6.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL540553 19861 0 None - 0 Mouse 8.7 pIC50 = 8.7 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 709 10 0 7 6.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
44319086 20484 0 None - 0 Mouse 8.7 pIC50 = 8.7 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 722 10 0 7 6.0 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCN(C)CC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL1194977 20484 0 None - 0 Mouse 8.7 pIC50 = 8.7 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 722 10 0 7 6.0 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCN(C)CC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL553617 20484 0 None - 0 Mouse 8.7 pIC50 = 8.7 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 722 10 0 7 6.0 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCN(C)CC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
9852376 105878 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor
ChEMBL 639 8 0 4 6.6 CS(=O)(=O)N1CC2(CCN(CCCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(Cc4ccccc4)C3)CC2)c2ccccc21 10.1016/s0960-894x(98)00215-7
CHEMBL280789 105878 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor
ChEMBL 639 8 0 4 6.6 CS(=O)(=O)N1CC2(CCN(CCCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(Cc4ccccc4)C3)CC2)c2ccccc21 10.1016/s0960-894x(98)00215-7
71699792 131563 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 636 5 0 3 7.5 CC(=O)C1CCC(C(=O)N2CC(c3ccc(Cl)c(Cl)c3)[C@H](N(C)C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
CHEMBL3642162 131563 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 636 5 0 3 7.5 CC(=O)C1CCC(C(=O)N2CC(c3ccc(Cl)c(Cl)c3)[C@H](N(C)C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
44404006 139534 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory concentration against tachykinin receptor 2Inhibitory concentration against tachykinin receptor 2
ChEMBL 549 7 1 3 5.7 NC(=O)C1(c2ccccc2)CCN(CC[C@@]2(c3ccc(Cl)c(Cl)c3)CCN(C(=O)c3ccccc3)C2)CC1 10.1021/jm058225d
CHEMBL370013 139534 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory concentration against tachykinin receptor 2Inhibitory concentration against tachykinin receptor 2
ChEMBL 549 7 1 3 5.7 NC(=O)C1(c2ccccc2)CCN(CC[C@@]2(c3ccc(Cl)c(Cl)c3)CCN(C(=O)c3ccccc3)C2)CC1 10.1021/jm058225d
71699788 131559 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 545 5 0 4 4.7 COc1ccc(C(=O)N(C)[C@@H]2CCN(C(=O)C3CCN(C(C)=O)CC3)CC2c2ccc(Cl)c(Cl)c2)cc1 nan
CHEMBL3642158 131559 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 545 5 0 4 4.7 COc1ccc(C(=O)N(C)[C@@H]2CCN(C(=O)C3CCN(C(C)=O)CC3)CC2c2ccc(Cl)c(Cl)c2)cc1 nan
73265455 133227 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 660 5 1 4 5.4 CN(C(=O)N(C)[C@@H]1CN(C(=O)C2CCN(C(=O)C(C)(C)O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL3651894 133227 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 660 5 1 4 5.4 CN(C(=O)N(C)[C@@H]1CN(C(=O)C2CCN(C(=O)C(C)(C)O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
3570748 64293 28 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligandBinding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand
ChEMBL 414 7 1 3 4.1 COC1(C[S+]([O-])c2ccccc2)CCN(CCc2c[nH]c3ccc(F)cc23)CC1 10.1016/s0960-894x(01)00074-9
CHEMBL166161 64293 28 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligandBinding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand
ChEMBL 414 7 1 3 4.1 COC1(C[S+]([O-])c2ccccc2)CCN(CCc2c[nH]c3ccc(F)cc23)CC1 10.1016/s0960-894x(01)00074-9
CHEMBL2390989 217190 16 None - 1 Human 8.6 pIC50 = 8.6 Binding
Binding affinity to human NK2 receptor by radioligand displacement assayBinding affinity to human NK2 receptor by radioligand displacement assay
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(N)=O 10.1016/j.bmc.2013.03.016
44276792 105907 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor
ChEMBL 604 8 1 4 6.5 O=C1CCC(CCCN2CCC3(CC2)CN(c2ccccc2)NC3=O)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1016/s0960-894x(98)00215-7
CHEMBL281019 105907 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor
ChEMBL 604 8 1 4 6.5 O=C1CCC(CCCN2CCC3(CC2)CN(c2ccccc2)NC3=O)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1016/s0960-894x(98)00215-7
44392445 73129 0 None - 1 Human 8.6 pIC50 = 8.6 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 495 8 0 3 5.2 O=C1CC[C@](CCN2CC(N3CCC(F)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CCC1CC1 10.1016/j.bmcl.2005.05.134
CHEMBL185133 73129 0 None - 1 Human 8.6 pIC50 = 8.6 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 495 8 0 3 5.2 O=C1CC[C@](CCN2CC(N3CCC(F)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CCC1CC1 10.1016/j.bmcl.2005.05.134
2098 10466 36 None - 6 Rat 6.7 pIC50 = 6.7 Binding
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None None 10.1021/jm00037a009
36511 10466 36 None - 6 Rat 6.7 pIC50 = 6.7 Binding
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None None 10.1021/jm00037a009
3805 10466 36 None - 6 Rat 6.7 pIC50 = 6.7 Binding
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None None 10.1021/jm00037a009
3835 10466 36 None - 6 Rat 6.7 pIC50 = 6.7 Binding
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None None 10.1021/jm00037a009
CHEMBL235363 10466 36 None - 6 Rat 6.7 pIC50 = 6.7 Binding
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None None 10.1021/jm00037a009
44335410 11772 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 574 7 1 2 7.5 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NC1CCCCCC1)Cc1ccc(Cl)cc1 10.1016/s0960-894x(01)00631-x
CHEMBL105009 11772 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 574 7 1 2 7.5 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NC1CCCCCC1)Cc1ccc(Cl)cc1 10.1016/s0960-894x(01)00631-x
44276738 103965 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor
ChEMBL 560 6 0 2 7.9 O=C(c1ccccc1)N1CCCC(CCCN2CCC3(CCc4ccccc43)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(98)00215-7
CHEMBL26831 103965 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor
ChEMBL 560 6 0 2 7.9 O=C(c1ccccc1)N1CCCC(CCCN2CCC3(CCc4ccccc43)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(98)00215-7
9874168 212483 4 None - 0 Mouse 7.7 pIC50 = 7.7 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL82386 212483 4 None - 0 Mouse 7.7 pIC50 = 7.7 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
44312169 211207 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 492 5 3 2 5.4 O=C(Nc1ccccc1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
CHEMBL72140 211207 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 492 5 3 2 5.4 O=C(Nc1ccccc1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
76287260 132525 25 None - 0 Human 4.7 pIC50 = 4.7 Binding
Displacement of [125I]NKA from recombinant human NK2 measured after 60 mins by scintillation counting methodDisplacement of [125I]NKA from recombinant human NK2 measured after 60 mins by scintillation counting method
ChEMBL 440 6 0 7 4.1 CCn1cnc2c(-c3ccc(F)c(-c4ccc(S(=O)(=O)CC)cc4OC)c3)cnnc21 10.1021/acs.jmedchem.9b00322
CHEMBL3647536 132525 25 None - 0 Human 4.7 pIC50 = 4.7 Binding
Displacement of [125I]NKA from recombinant human NK2 measured after 60 mins by scintillation counting methodDisplacement of [125I]NKA from recombinant human NK2 measured after 60 mins by scintillation counting method
ChEMBL 440 6 0 7 4.1 CCn1cnc2c(-c3ccc(F)c(-c4ccc(S(=O)(=O)CC)cc4OC)c3)cnnc21 10.1021/acs.jmedchem.9b00322
44312145 211495 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 520 7 3 2 5.1 O=C(NCCc1ccccc1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
CHEMBL74176 211495 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 520 7 3 2 5.1 O=C(NCCc1ccccc1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
9843958 207572 1 None - 1 Human 7.7 pIC50 = 7.7 Binding
Binding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligandBinding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand
ChEMBL 400 6 2 3 3.5 [O-][S+](CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1)c1ccccc1 10.1016/s0960-894x(01)00074-9
CHEMBL60064 207572 1 None - 1 Human 7.7 pIC50 = 7.7 Binding
Binding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligandBinding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand
ChEMBL 400 6 2 3 3.5 [O-][S+](CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1)c1ccccc1 10.1016/s0960-894x(01)00074-9
1212 8443 50 None -389 65 Human 4.7 pIC50 = 4.7 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F nan
204 8443 50 None -389 65 Human 4.7 pIC50 = 4.7 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F nan
3372 8443 50 None -389 65 Human 4.7 pIC50 = 4.7 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F nan
CHEMBL726 8443 50 None -389 65 Human 4.7 pIC50 = 4.7 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F nan
DB00623 8443 50 None -389 65 Human 4.7 pIC50 = 4.7 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F nan
44319250 113784 0 None - 0 Mouse 6.6 pIC50 = 6.6 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 589 10 1 6 4.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(F)cc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL315322 113784 0 None - 0 Mouse 6.6 pIC50 = 6.6 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 589 10 1 6 4.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(F)cc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
10099939 11759 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(01)00631-x
CHEMBL104954 11759 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(01)00631-x
9830304 114124 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 608 7 2 4 5.2 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1cn(C)c2ccccc12 10.1016/s0960-894x(01)00631-x
CHEMBL317632 114124 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 608 7 2 4 5.2 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1cn(C)c2ccccc12 10.1016/s0960-894x(01)00631-x
10099939 11759 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
CHEMBL104954 11759 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
44312257 109687 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 567 7 2 4 5.6 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
CHEMBL306065 109687 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 567 7 2 4 5.6 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
25129133 195666 0 None -10 4 Rat 7.6 pIC50 = 7.6 Binding
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
CHEMBL507340 195666 0 None -10 4 Rat 7.6 pIC50 = 7.6 Binding
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
23653789 10359 24 None 1 2 Human 5.6 pIC50 = 5.6 Binding
Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm400751p
9280 10359 24 None 1 2 Human 5.6 pIC50 = 5.6 Binding
Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm400751p
CHEMBL447955 10359 24 None 1 2 Human 5.6 pIC50 = 5.6 Binding
Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm400751p
DB12973 10359 24 None 1 2 Human 5.6 pIC50 = 5.6 Binding
Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm400751p
10350528 113510 0 None - 3 Rat 6.6 pIC50 = 6.6 Binding
Tested for binding affinity against rat NK-2 receptorTested for binding affinity against rat NK-2 receptor
ChEMBL 831 18 4 9 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144210 113510 0 None - 3 Rat 6.6 pIC50 = 6.6 Binding
Tested for binding affinity against rat NK-2 receptorTested for binding affinity against rat NK-2 receptor
ChEMBL 831 18 4 9 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
2098 10466 36 None -457 6 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
36511 10466 36 None -457 6 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
3805 10466 36 None -457 6 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
3835 10466 36 None -457 6 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
CHEMBL235363 10466 36 None -457 6 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
44379971 65527 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Binding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligandBinding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand
ChEMBL 398 3 2 3 3.5 [O-][S+](C[C@]1(O)CCN2CCc3c([nH]c4ccc(F)cc34)[C@H]2C1)c1ccccc1 10.1016/s0960-894x(01)00074-9
CHEMBL168632 65527 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Binding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligandBinding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand
ChEMBL 398 3 2 3 3.5 [O-][S+](C[C@]1(O)CCN2CCc3c([nH]c4ccc(F)cc34)[C@H]2C1)c1ccccc1 10.1016/s0960-894x(01)00074-9
44312028 109629 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 558 9 1 5 5.1 CSN1CC2(CCN(C(=O)N[C@@H](COCc3ccccc3)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
CHEMBL305609 109629 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 558 9 1 5 5.1 CSN1CC2(CCN(C(=O)N[C@@H](COCc3ccccc3)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
44335376 11317 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 717 7 2 4 6.3 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1cc(Br)c(Br)s1 10.1016/s0960-894x(01)00631-x
CHEMBL102376 11317 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 717 7 2 4 6.3 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1cc(Br)c(Br)s1 10.1016/s0960-894x(01)00631-x
155565189 182344 0 None 2 4 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter methodDisplacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter method
ChEMBL 634 7 0 9 6.2 CC(C)CCO[C@H]1[C@H]2CCN(CCc3ccc4ccccc4c3)CCCCCCOCc3cn(nn3)C[C@@H](O2)[C@@H]2OC(C)(C)O[C@H]12 10.1016/j.ejmech.2019.04.064
CHEMBL4579120 182344 0 None 2 4 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter methodDisplacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter method
ChEMBL 634 7 0 9 6.2 CC(C)CCO[C@H]1[C@H]2CCN(CCc3ccc4ccccc4c3)CCCCCCOCc3cn(nn3)C[C@@H](O2)[C@@H]2OC(C)(C)O[C@H]12 10.1016/j.ejmech.2019.04.064
392622 63086 95 None 2 4 Human 5.6 pIC50 = 5.6 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 720 17 4 9 5.9 CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1 nan
CHEMBL163 63086 95 None 2 4 Human 5.6 pIC50 = 5.6 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 720 17 4 9 5.9 CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1 nan
28417 46813 49 None -1 12 Human 4.6 pIC50 = 4.6 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 337 0 1 3 4.2 C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C nan
CHEMBL1479 46813 49 None -1 12 Human 4.6 pIC50 = 4.6 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 337 0 1 3 4.2 C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C nan
2600 10551 74 None -6 13 Human 5.6 pIC50 = 5.6 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O nan
2608 10551 74 None -6 13 Human 5.6 pIC50 = 5.6 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O nan
5405 10551 74 None -6 13 Human 5.6 pIC50 = 5.6 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O nan
CHEMBL17157 10551 74 None -6 13 Human 5.6 pIC50 = 5.6 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O nan
DB00342 10551 74 None -6 13 Human 5.6 pIC50 = 5.6 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O nan
9984184 211428 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 520 6 2 2 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
CHEMBL73618 211428 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 520 6 2 2 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
CHEMBL2112246 216012 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Tested for binding affinity against Tachykinin receptor 2 expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against Tachykinin receptor 2 expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None C[C@H](NC(=O)CN)C(=O)N[C@H]1CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O 10.1021/jm000316h
2726 7706 68 None -125 72 Human 4.6 pIC50 = 4.6 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C nan
621 7706 68 None -125 72 Human 4.6 pIC50 = 4.6 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C nan
83 7706 68 None -125 72 Human 4.6 pIC50 = 4.6 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C nan
CHEMBL71 7706 68 None -125 72 Human 4.6 pIC50 = 4.6 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C nan
DB00477 7706 68 None -125 72 Human 4.6 pIC50 = 4.6 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C nan
10055928 123403 0 None - 0 Golden hamster 6.6 pIC50 = 6.6 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 762 25 9 10 -1.0 CCN(C[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)[C@@H](CC(C)C)C(N)=O 10.1021/jm00099a024
CHEMBL336849 123403 0 None - 0 Golden hamster 6.6 pIC50 = 6.6 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 762 25 9 10 -1.0 CCN(C[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)[C@@H](CC(C)C)C(N)=O 10.1021/jm00099a024
44319249 212851 0 None - 0 Mouse 5.6 pIC50 = 5.6 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 631 12 1 8 4.4 COc1ccc(C2(CCN3CCC(C(N)=O)(c4ccccc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1016/S0960-894X(97)10013-0
CHEMBL85499 212851 0 None - 0 Mouse 5.6 pIC50 = 5.6 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 631 12 1 8 4.4 COc1ccc(C2(CCN3CCC(C(N)=O)(c4ccccc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1016/S0960-894X(97)10013-0
9869033 107200 5 None - 0 Bovine 5.6 pIC50 = 5.6 Binding
Compound was tested for inhibition of [125I]NKA radioligand binding to NK2 receptor from bovine bladderCompound was tested for inhibition of [125I]NKA radioligand binding to NK2 receptor from bovine bladder
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
CHEMBL290364 107200 5 None - 0 Bovine 5.6 pIC50 = 5.6 Binding
Compound was tested for inhibition of [125I]NKA radioligand binding to NK2 receptor from bovine bladderCompound was tested for inhibition of [125I]NKA radioligand binding to NK2 receptor from bovine bladder
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
71450941 86294 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 595 5 2 3 6.2 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)N[C@@H]2CCCCNC2=O)ccc1-c1ccc(F)cc1 10.1016/s0960-894x(02)00382-7
CHEMBL2113739 86294 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 595 5 2 3 6.2 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)N[C@@H]2CCCCNC2=O)ccc1-c1ccc(F)cc1 10.1016/s0960-894x(02)00382-7
16220269 196439 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Inhibition of neurokinin 2 receptorInhibition of neurokinin 2 receptor
ChEMBL 361 3 1 2 4.4 CC[C@@H]1O[C@](/C=C/C2CC2)(C(F)(F)F)c2c(ccc(F)c2F)NC1=O 10.1073/pnas.0605125104
CHEMBL515170 196439 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Inhibition of neurokinin 2 receptorInhibition of neurokinin 2 receptor
ChEMBL 361 3 1 2 4.4 CC[C@@H]1O[C@](/C=C/C2CC2)(C(F)(F)F)c2c(ccc(F)c2F)NC1=O 10.1073/pnas.0605125104
53232 195404 95 None 1 2 Human 4.6 pIC50 = 4.6 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 404 6 1 5 4.2 CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21 nan
CHEMBL503 195404 95 None 1 2 Human 4.6 pIC50 = 4.6 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 404 6 1 5 4.2 CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21 nan
CHEMBL2115376 216046 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)[C@H]1CCc2ccccc21)C(N)=O 10.1021/jm00037a009
CHEMBL2369767 216463 0 None - 0 Golden hamster 5.5 pIC50 = 5.5 Binding
Concentration producing half-maximal inhibition of specific binding of. [125I]neurokinin A to NK-2 receptors in the hamster urinary bladderConcentration producing half-maximal inhibition of specific binding of. [125I]neurokinin A to NK-2 receptors in the hamster urinary bladder
ChEMBL None None None C/C=C/CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCC(=O)N1)C(N)=O 10.1016/0960-894X(94)85022-4
64143 205643 62 None -1 8 Human 4.5 pIC50 = 4.5 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 567 9 4 6 4.7 Cc1c(O)cccc1C(=O)N[C@@H](CSc1ccccc1)[C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C nan
CHEMBL584 205643 62 None -1 8 Human 4.5 pIC50 = 4.5 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 567 9 4 6 4.7 Cc1c(O)cccc1C(=O)N[C@@H](CSc1ccccc1)[C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C nan
2247 7293 81 None -44 42 Human 5.5 pIC50 = 5.5 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
249 7293 81 None -44 42 Human 5.5 pIC50 = 5.5 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
2603 7293 81 None -44 42 Human 5.5 pIC50 = 5.5 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
CHEMBL296419 7293 81 None -44 42 Human 5.5 pIC50 = 5.5 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
DB00637 7293 81 None -44 42 Human 5.5 pIC50 = 5.5 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
9831641 86472 5 None - 0 Guinea pig 8.5 pIC50 = 8.5 Binding
The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membrane
ChEMBL 672 8 0 7 6.0 COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[S@+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(00)00324-3
CHEMBL2115415 86472 5 None - 0 Guinea pig 8.5 pIC50 = 8.5 Binding
The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membrane
ChEMBL 672 8 0 7 6.0 COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[S@+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(00)00324-3
44319224 113853 0 None - 0 Mouse 8.5 pIC50 = 8.5 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 722 10 0 7 6.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)N4CCN(C)CC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL315814 113853 0 None - 0 Mouse 8.5 pIC50 = 8.5 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 722 10 0 7 6.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)N4CCN(C)CC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
44392392 136951 0 None - 1 Human 8.5 pIC50 = 8.5 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 555 7 0 4 5.4 O=C1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CCC(F)(F)CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL367815 136951 0 None - 1 Human 8.5 pIC50 = 8.5 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 555 7 0 4 5.4 O=C1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CCC(F)(F)CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
127032997 145310 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]NKA from human recombinant NK2 receptor expressed in CHO cellsDisplacement of [125I]NKA from human recombinant NK2 receptor expressed in CHO cells
ChEMBL 748 24 10 10 -2.1 CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(N)=O 10.1016/j.bmc.2016.03.006
CHEMBL3775108 145310 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]NKA from human recombinant NK2 receptor expressed in CHO cellsDisplacement of [125I]NKA from human recombinant NK2 receptor expressed in CHO cells
ChEMBL 748 24 10 10 -2.1 CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(N)=O 10.1016/j.bmc.2016.03.006
CHEMBL2390989 217190 16 None - 1 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]NKA from human recombinant NK2 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [125I]NKA from human recombinant NK2 receptor expressed in CHO cells measured after 60 mins by scintillation counting method
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(N)=O 10.1016/j.bmc.2016.11.014
137633652 163375 0 None - 1 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]NKA from human recombinant tachykinin NK2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [125I]NKA from human recombinant tachykinin NK2 receptor expressed in CHO cells after 60 mins by scintillation counting
ChEMBL 749 24 10 10 -1.5 CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)O 10.1021/acs.jmedchem.6b01422
CHEMBL4068783 163375 0 None - 1 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]NKA from human recombinant tachykinin NK2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [125I]NKA from human recombinant tachykinin NK2 receptor expressed in CHO cells after 60 mins by scintillation counting
ChEMBL 749 24 10 10 -1.5 CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)O 10.1021/acs.jmedchem.6b01422
2090 9543 25 None - 4 Golden hamster 8.4 pIC50 = 8.4 Binding
Inhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKAInhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKA
ChEMBL None None None None 10.1021/jm950892r
5311312 9543 25 None - 4 Golden hamster 8.4 pIC50 = 8.4 Binding
Inhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKAInhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKA
ChEMBL None None None None 10.1021/jm950892r
CHEMBL437797 9543 25 None - 4 Golden hamster 8.4 pIC50 = 8.4 Binding
Inhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKAInhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKA
ChEMBL None None None None 10.1021/jm950892r
44319308 113155 0 None - 0 Mouse 8.4 pIC50 = 8.4 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 709 10 0 7 6.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)N4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL313931 113155 0 None - 0 Mouse 8.4 pIC50 = 8.4 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 709 10 0 7 6.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)N4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
15485361 104005 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor
ChEMBL 576 9 0 3 7.5 CC(=O)C1(c2ccccc2)CCN(CCCC2(c3ccc(Cl)c(Cl)c3)CCC(=O)N(Cc3ccccc3)C2)CC1 10.1016/s0960-894x(98)00215-7
CHEMBL26860 104005 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor
ChEMBL 576 9 0 3 7.5 CC(=O)C1(c2ccccc2)CCN(CCCC2(c3ccc(Cl)c(Cl)c3)CCC(=O)N(Cc3ccccc3)C2)CC1 10.1016/s0960-894x(98)00215-7
9915372 133837 1 None -1 2 Human 8.4 pIC50 = 8.4 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 543 8 1 5 2.2 NS(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL365613 133837 1 None -1 2 Human 8.4 pIC50 = 8.4 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 543 8 1 5 2.2 NS(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
44305557 209592 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards tachykinin receptor 2Binding affinity towards tachykinin receptor 2
ChEMBL 522 8 2 5 6.3 COc1cc(C(=O)Nc2cc(C(=O)NC3CCCCC3)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC 10.1021/jm058225d
CHEMBL62341 209592 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards tachykinin receptor 2Binding affinity towards tachykinin receptor 2
ChEMBL 522 8 2 5 6.3 COc1cc(C(=O)Nc2cc(C(=O)NC3CCCCC3)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC 10.1021/jm058225d
44305557 209592 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 522 8 2 5 6.3 COc1cc(C(=O)Nc2cc(C(=O)NC3CCCCC3)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC 10.1016/s0960-894x(02)00382-7
CHEMBL62341 209592 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 522 8 2 5 6.3 COc1cc(C(=O)Nc2cc(C(=O)NC3CCCCC3)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC 10.1016/s0960-894x(02)00382-7
CHEMBL431641 220405 0 None - 1 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2
ChEMBL None None None CC(C)CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(C)C)C(N)=O 10.1021/jm9807151
71458099 86366 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
CHEMBL2114398 86366 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
155558726 181587 0 None -3 4 Human 5.5 pIC50 = 5.5 Binding
Displacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter methodDisplacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter method
ChEMBL 835 11 0 13 6.7 CC(C)CCO[C@H]1[C@H]2CCN(CCc3ccc4ccccc4c3)CC[C@H]3O[C@H](Cn4cc(nn4)COC[C@@H](O2)[C@@H]2OC(C)(C)O[C@H]12)[C@@H]1OC(C)(C)O[C@@H]1[C@H]3OCCC(C)C 10.1016/j.ejmech.2019.04.064
CHEMBL4562303 181587 0 None -3 4 Human 5.5 pIC50 = 5.5 Binding
Displacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter methodDisplacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter method
ChEMBL 835 11 0 13 6.7 CC(C)CCO[C@H]1[C@H]2CCN(CCc3ccc4ccccc4c3)CC[C@H]3O[C@H](Cn4cc(nn4)COC[C@@H](O2)[C@@H]2OC(C)(C)O[C@H]12)[C@@H]1OC(C)(C)O[C@@H]1[C@H]3OCCC(C)C 10.1016/j.ejmech.2019.04.064
5353853 24758 47 None -14 15 Human 5.5 pIC50 = 5.5 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 427 6 0 4 6.1 Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
9556529 24758 47 None -14 15 Human 5.5 pIC50 = 5.5 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 427 6 0 4 6.1 Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL1262 24758 47 None -14 15 Human 5.5 pIC50 = 5.5 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 427 6 0 4 6.1 Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
44301871 107524 5 None - 1 Golden hamster 5.5 pIC50 = 5.5 Binding
Concentration required for binding affinity to neurokinin (NK2) receptor in hamster urinary bladderConcentration required for binding affinity to neurokinin (NK2) receptor in hamster urinary bladder
ChEMBL 441 9 3 3 4.4 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1)OCc1ccccc1 10.1016/S0960-894X(97)00346-6
CHEMBL292766 107524 5 None - 1 Golden hamster 5.5 pIC50 = 5.5 Binding
Concentration required for binding affinity to neurokinin (NK2) receptor in hamster urinary bladderConcentration required for binding affinity to neurokinin (NK2) receptor in hamster urinary bladder
ChEMBL 441 9 3 3 4.4 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1)OCc1ccccc1 10.1016/S0960-894X(97)00346-6
CHEMBL311405 217878 16 None - 0 Golden hamster 5.5 pIC50 = 5.5 Binding
Concentration producing half-maximal inhibition of specific binding of. [125I]neurokinin A to NK-2 receptors in the hamster urinary bladderConcentration producing half-maximal inhibition of specific binding of. [125I]neurokinin A to NK-2 receptors in the hamster urinary bladder
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CCC(N)=O)C(N)=O 10.1016/0960-894X(94)85022-4
44212284 66762 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 609 9 1 5 5.7 COc1ccc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c(OC)c1 10.1016/0960-894X(96)00148-5
CHEMBL173420 66762 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 609 9 1 5 5.7 COc1ccc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c(OC)c1 10.1016/0960-894X(96)00148-5
CHEMBL102128 215233 0 None - 1 Human 5.5 pIC50 = 5.5 Binding
Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2
ChEMBL None None None CC(C)CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(C)C)C(N)=O 10.1021/jm9807151
23294214 175939 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor
ChEMBL 590 7 1 4 6.9 O=C(c1ccccc1)N1CCCC(CCCN2CCC(n3c(=O)[nH]c4ccccc43)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(98)00215-7
CHEMBL440465 175939 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor
ChEMBL 590 7 1 4 6.9 O=C(c1ccccc1)N1CCCC(CCCN2CCC(n3c(=O)[nH]c4ccccc43)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(98)00215-7
CHEMBL406442 219387 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(c1ccccc1)c1ccccc1)C(N)=O 10.1021/jm00037a009
1016 10519 78 None -16 35 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
2561 10519 78 None -16 35 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
2733526 10519 78 None -16 35 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
5384 10519 78 None -16 35 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
CHEMBL83 10519 78 None -16 35 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
DB00675 10519 78 None -16 35 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
CHEMBL103939 215239 0 None - 1 Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2
ChEMBL None None None CC(C)CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(N)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(C)C)C(N)=O 10.1021/jm9807151
CHEMBL2115375 216045 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)[C@H]1CCc2ccccc21)C(N)=O 10.1021/jm00037a009
1836 9370 59 None -40 15 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 nan
3340 9370 59 None -40 15 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 nan
5281040 9370 59 None -40 15 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 nan
CHEMBL787 9370 59 None -40 15 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 nan
DB00471 9370 59 None -40 15 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 nan
9832198 113532 0 None - 3 Rat 6.4 pIC50 = 6.4 Binding
Tested for binding affinity against rat NK-2 receptorTested for binding affinity against rat NK-2 receptor
ChEMBL 788 15 4 8 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCC(=O)O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144351 113532 0 None - 3 Rat 6.4 pIC50 = 6.4 Binding
Tested for binding affinity against rat NK-2 receptorTested for binding affinity against rat NK-2 receptor
ChEMBL 788 15 4 8 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCC(=O)O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
10393390 105053 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor
ChEMBL 576 8 0 3 7.6 CC(=O)C1(c2ccccc2)CCN(CCCC2(c3ccc(Cl)c(Cl)c3)CCCN(C(=O)c3ccccc3)C2)CC1 10.1016/s0960-894x(98)00215-7
CHEMBL27463 105053 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor
ChEMBL 576 8 0 3 7.6 CC(=O)C1(c2ccccc2)CCN(CCCC2(c3ccc(Cl)c(Cl)c3)CCCN(C(=O)c3ccccc3)C2)CC1 10.1016/s0960-894x(98)00215-7
CHEMBL216813 216120 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1Cc2ccccc2C1)C(N)=O 10.1021/jm00037a009
132837 9018 55 None -18 5 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm100157m
9461 9018 55 None -18 5 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm100157m
CHEMBL22870 9018 55 None -18 5 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm100157m
2351 10059 64 None -13 21 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O nan
2820 10059 64 None -13 21 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O nan
5035 10059 64 None -13 21 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O nan
CHEMBL81 10059 64 None -13 21 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O nan
DB00481 10059 64 None -13 21 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O nan
44386230 68137 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 735 8 1 4 7.2 COc1c(Br)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1Br 10.1016/0960-894X(96)00148-5
CHEMBL176811 68137 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 735 8 1 4 7.2 COc1c(Br)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1Br 10.1016/0960-894X(96)00148-5
44319084 20469 0 None - 0 Mouse 8.4 pIC50 = 8.4 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 723 10 0 8 5.4 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCN(C)CC4)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL1194867 20469 0 None - 0 Mouse 8.4 pIC50 = 8.4 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 723 10 0 8 5.4 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCN(C)CC4)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL553451 20469 0 None - 0 Mouse 8.4 pIC50 = 8.4 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 723 10 0 8 5.4 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCN(C)CC4)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
133 9274 52 None -165 43 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C nan
1723 9274 52 None -165 43 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C nan
28693 9274 52 None -165 43 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C nan
CHEMBL19215 9274 52 None -165 43 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C nan
DB13520 9274 52 None -165 43 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C nan
CHEMBL405209 219328 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1c2ccccc2-c2ccccc21)C(N)=O 10.1021/jm00037a009
49863731 22102 0 None -5 3 Rat 7.4 pIC50 = 7.4 Binding
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 1266 18 10 12 6.1 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
CHEMBL1214024 22102 0 None -5 3 Rat 7.4 pIC50 = 7.4 Binding
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 1266 18 10 12 6.1 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
1024 8072 71 None - 1 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL None None None None nan
162639143 8072 71 None - 1 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL None None None None nan
5284373 8072 71 None - 1 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL None None None None nan
760 8072 71 None - 1 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL None None None None nan
CHEMBL160 8072 71 None - 1 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL None None None None nan
DB00091 8072 71 None - 1 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL None None None None nan
3598 194600 76 None -1 7 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 404 2 2 2 6.6 Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl nan
CHEMBL496 194600 76 None -1 7 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 404 2 2 2 6.6 Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl nan
73265454 133226 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 646 5 1 4 6.3 COC(=O)N[C@H]1CC[C@H](C(=O)N2C[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 nan
CHEMBL3651893 133226 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 646 5 1 4 6.3 COC(=O)N[C@H]1CC[C@H](C(=O)N2C[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 nan
44384677 138236 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 667 11 1 6 6.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC(C)C 10.1016/0960-894X(96)00148-5
CHEMBL369174 138236 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 667 11 1 6 6.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC(C)C 10.1016/0960-894X(96)00148-5
73265449 131190 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 630 4 0 3 6.0 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 nan
CHEMBL3639507 131190 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 630 4 0 3 6.0 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 nan
44312285 109734 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 703 7 2 4 7.6 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
CHEMBL306400 109734 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 703 7 2 4 7.6 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
122179477 128252 5 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of NK2 receptor (unknown origin)Inhibition of NK2 receptor (unknown origin)
ChEMBL 525 5 3 9 3.2 CCn1cc([C@@]2(c3nn(C)c(=O)o3)N[C@@H](c3nc(-c4ccc(F)cn4)c[nH]3)Cc3c2[nH]c2ccccc32)cn1 10.1021/ml500514w
CHEMBL3582336 128252 5 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of NK2 receptor (unknown origin)Inhibition of NK2 receptor (unknown origin)
ChEMBL 525 5 3 9 3.2 CCn1cc([C@@]2(c3nn(C)c(=O)o3)N[C@@H](c3nc(-c4ccc(F)cn4)c[nH]3)Cc3c2[nH]c2ccccc32)cn1 10.1021/ml500514w
71449072 85353 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 645 5 2 3 7.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)N[C@@H]2CCCCNC2=O)ccc1-c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00382-7
CHEMBL2112212 85353 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 645 5 2 3 7.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)N[C@@H]2CCCCNC2=O)ccc1-c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00382-7
11059058 16863 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Binding affinity against tachykinin receptor 2Binding affinity against tachykinin receptor 2
ChEMBL 429 3 1 7 4.1 O=C(OCc1cc2c(cc1Cl)OCO2)N1CCC(n2c(O)nc3ccccc32)CC1 10.1021/jm010878g
CHEMBL115444 16863 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Binding affinity against tachykinin receptor 2Binding affinity against tachykinin receptor 2
ChEMBL 429 3 1 7 4.1 O=C(OCc1cc2c(cc1Cl)OCO2)N1CCC(n2c(O)nc3ccccc32)CC1 10.1021/jm010878g
10350454 113508 0 None - 3 Human 7.4 pIC50 = 7.4 Binding
Tested for binding affinity against human NK-2 receptorTested for binding affinity against human NK-2 receptor
ChEMBL 815 18 4 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144209 113508 0 None - 3 Human 7.4 pIC50 = 7.4 Binding
Tested for binding affinity against human NK-2 receptorTested for binding affinity against human NK-2 receptor
ChEMBL 815 18 4 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44290659 108310 0 None - 0 Guinea pig 7.4 pIC50 = 7.4 Binding
The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membrane
ChEMBL 654 8 1 7 5.7 COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[C@H]4O)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(00)00324-3
CHEMBL298247 108310 0 None - 0 Guinea pig 7.4 pIC50 = 7.4 Binding
The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membrane
ChEMBL 654 8 1 7 5.7 COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[C@H]4O)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(00)00324-3
CHEMBL411230 219653 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CCc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O 10.1021/jm00037a009
44288896 175766 0 None - 0 Bovine 5.4 pIC50 = 5.4 Binding
Compound was tested for inhibition of [125I]NKA radioligand binding to NK2 receptor from bovine bladderCompound was tested for inhibition of [125I]NKA radioligand binding to NK2 receptor from bovine bladder
ChEMBL 517 5 1 3 6.2 O=C(N[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1)c1ccnc2ccccc12 10.1016/0960-894X(96)00287-9
CHEMBL43912 175766 0 None - 0 Bovine 5.4 pIC50 = 5.4 Binding
Compound was tested for inhibition of [125I]NKA radioligand binding to NK2 receptor from bovine bladderCompound was tested for inhibition of [125I]NKA radioligand binding to NK2 receptor from bovine bladder
ChEMBL 517 5 1 3 6.2 O=C(N[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1)c1ccnc2ccccc12 10.1016/0960-894X(96)00287-9
44312256 211359 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 554 7 2 5 5.7 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
CHEMBL73097 211359 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 554 7 2 5 5.7 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
1752 52535 59 None -1 5 Human 5.3 pIC50 = 5.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 220 8 1 1 4.7 CCCCCCCCCc1ccc(O)cc1 nan
CHEMBL153062 52535 59 None -1 5 Human 5.3 pIC50 = 5.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 220 8 1 1 4.7 CCCCCCCCCc1ccc(O)cc1 nan
1548953 214458 27 None -7 17 Human 5.3 pIC50 = 5.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 405 9 0 2 6.6 CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1 nan
CHEMBL954 214458 27 None -7 17 Human 5.3 pIC50 = 5.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 405 9 0 2 6.6 CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1 nan
CHEMBL1201469 21279 0 None 1 4 Human 5.3 pIC50 = 5.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL None None None None nan
CHEMBL2112245 216011 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Tested for binding affinity against Tachykinin receptor 2 expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against Tachykinin receptor 2 expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC1=O 10.1021/jm000316h
10350528 113510 0 None - 3 Human 7.3 pIC50 = 7.3 Binding
Tested for binding affinity against human NK-2 receptorTested for binding affinity against human NK-2 receptor
ChEMBL 831 18 4 9 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144210 113510 0 None - 3 Human 7.3 pIC50 = 7.3 Binding
Tested for binding affinity against human NK-2 receptorTested for binding affinity against human NK-2 receptor
ChEMBL 831 18 4 9 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
11951302 111621 0 None - 1 Human 4.3 pIC50 = 4.3 Binding
Antagonist activity at human NK2 receptorAntagonist activity at human NK2 receptor
ChEMBL 404 7 2 5 3.5 COCCOc1ncc(C(=O)N[C@@H]2CCCC[C@H]2O)cc1-c1ccc(Cl)cc1 10.1021/jm4010708
CHEMBL3109772 111621 0 None - 1 Human 4.3 pIC50 = 4.3 Binding
Antagonist activity at human NK2 receptorAntagonist activity at human NK2 receptor
ChEMBL 404 7 2 5 3.5 COCCOc1ncc(C(=O)N[C@@H]2CCCC[C@H]2O)cc1-c1ccc(Cl)cc1 10.1021/jm4010708
2406 107180 89 None -16 12 Human 5.3 pIC50 = 5.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 354 2 2 3 5.9 Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O nan
CHEMBL290106 107180 89 None -16 12 Human 5.3 pIC50 = 5.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 354 2 2 3 5.9 Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O nan
4189 213701 96 None -18 34 Human 5.3 pIC50 = 5.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL1559 213701 96 None -18 34 Human 5.3 pIC50 = 5.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL91 213701 96 None -18 34 Human 5.3 pIC50 = 5.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
10439730 113534 0 None - 3 Rat 6.3 pIC50 = 6.3 Binding
Tested for binding affinity against rat NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for binding affinity against rat NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligand
ChEMBL 702 12 3 6 3.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144353 113534 0 None - 3 Rat 6.3 pIC50 = 6.3 Binding
Tested for binding affinity against rat NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for binding affinity against rat NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligand
ChEMBL 702 12 3 6 3.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44402934 77847 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity towards tachykinin receptor 2Binding affinity towards tachykinin receptor 2
ChEMBL 589 9 1 3 6.2 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NCCN1CCCCC1)Cc1ccc(Cl)cc1 10.1021/jm058225d
CHEMBL195222 77847 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity towards tachykinin receptor 2Binding affinity towards tachykinin receptor 2
ChEMBL 589 9 1 3 6.2 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NCCN1CCCCC1)Cc1ccc(Cl)cc1 10.1021/jm058225d
10379 9833 39 None - 1 Human 5.3 pIC50 = 5.3 Binding
Binding affinity to human neurokinin 2 receptorBinding affinity to human neurokinin 2 receptor
ChEMBL 340 5 1 7 3.3 CC[C@H](Nc1nc(C)nc2n1nc(c2c1ccc(nc1C)OC)C)C 10.1021/jm900025h
9884366 9833 39 None - 1 Human 5.3 pIC50 = 5.3 Binding
Binding affinity to human neurokinin 2 receptorBinding affinity to human neurokinin 2 receptor
ChEMBL 340 5 1 7 3.3 CC[C@H](Nc1nc(C)nc2n1nc(c2c1ccc(nc1C)OC)C)C 10.1021/jm900025h
CHEMBL482950 9833 39 None - 1 Human 5.3 pIC50 = 5.3 Binding
Binding affinity to human neurokinin 2 receptorBinding affinity to human neurokinin 2 receptor
ChEMBL 340 5 1 7 3.3 CC[C@H](Nc1nc(C)nc2n1nc(c2c1ccc(nc1C)OC)C)C 10.1021/jm900025h
DB12572 9833 39 None - 1 Human 5.3 pIC50 = 5.3 Binding
Binding affinity to human neurokinin 2 receptorBinding affinity to human neurokinin 2 receptor
ChEMBL 340 5 1 7 3.3 CC[C@H](Nc1nc(C)nc2n1nc(c2c1ccc(nc1C)OC)C)C 10.1021/jm900025h
CHEMBL264341 217393 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)/C(=C/c1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O 10.1021/jm00037a009
5318 22348 49 None -1 13 Human 5.3 pIC50 = 5.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 396 6 0 3 6.5 Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
CHEMBL1200348 22348 49 None -1 13 Human 5.3 pIC50 = 5.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 396 6 0 3 6.5 Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
CHEMBL1221 22348 49 None -1 13 Human 5.3 pIC50 = 5.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 396 6 0 3 6.5 Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
9939040 11782 7 None -2 4 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00631-x
CHEMBL105060 11782 7 None -2 4 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00631-x
44335319 114287 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 626 8 2 4 5.7 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(CCC(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00631-x
CHEMBL318606 114287 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 626 8 2 4 5.7 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(CCC(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00631-x
25109291 198165 10 None -72 8 Human 8.2 pIC50 = 8.2 Binding
Displacement of radiolabeled [Nle10]-NKA(4-10) from human NK2 receptorDisplacement of radiolabeled [Nle10]-NKA(4-10) from human NK2 receptor
ChEMBL 327 1 2 6 1.7 Nc1nc2c(c(N3CCNCC3)n1)CCC1=C2[C@@H]2CCCC[C@@H]2O1 10.1021/jm8007618
CHEMBL519240 198165 10 None -72 8 Human 8.2 pIC50 = 8.2 Binding
Displacement of radiolabeled [Nle10]-NKA(4-10) from human NK2 receptorDisplacement of radiolabeled [Nle10]-NKA(4-10) from human NK2 receptor
ChEMBL 327 1 2 6 1.7 Nc1nc2c(c(N3CCNCC3)n1)CCC1=C2[C@@H]2CCCC[C@@H]2O1 10.1021/jm8007618
10101612 124075 0 None - 0 Golden hamster 7.3 pIC50 = 7.3 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 752 25 10 11 -2.0 CSCC[C@H](NC[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(N)=O 10.1021/jm00099a024
CHEMBL339615 124075 0 None - 0 Golden hamster 7.3 pIC50 = 7.3 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 752 25 10 11 -2.0 CSCC[C@H](NC[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(N)=O 10.1021/jm00099a024
44276673 104132 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor
ChEMBL 604 7 1 4 6.6 O=C(c1ccccc1)N1CCCC(CCCN2CCC3(CC2)CN(c2ccccc2)NC3=O)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(98)00215-7
CHEMBL26951 104132 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor
ChEMBL 604 7 1 4 6.6 O=C(c1ccccc1)N1CCCC(CCCN2CCC3(CC2)CN(c2ccccc2)NC3=O)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(98)00215-7
11989776 9481 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of human NK2 receptorInhibition of human NK2 receptor
ChEMBL 569 5 1 6 5.9 COC(=O)N(c1ccccc1)NC(=O)c1c(CN2CCN(CC2)C(C)(C)C)c(nc2c1cccc2F)c1ccccc1 10.1016/j.bmcl.2006.08.085
2130 9481 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of human NK2 receptorInhibition of human NK2 receptor
ChEMBL 569 5 1 6 5.9 COC(=O)N(c1ccccc1)NC(=O)c1c(CN2CCN(CC2)C(C)(C)C)c(nc2c1cccc2F)c1ccccc1 10.1016/j.bmcl.2006.08.085
CHEMBL221445 9481 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of human NK2 receptorInhibition of human NK2 receptor
ChEMBL 569 5 1 6 5.9 COC(=O)N(c1ccccc1)NC(=O)c1c(CN2CCN(CC2)C(C)(C)C)c(nc2c1cccc2F)c1ccccc1 10.1016/j.bmcl.2006.08.085
44305271 109021 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 528 4 0 2 7.0 CN(C)C(=O)c1ccc(-c2ccc(Cl)cc2)c(N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1 10.1016/s0960-894x(02)00382-7
CHEMBL303119 109021 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 528 4 0 2 7.0 CN(C)C(=O)c1ccc(-c2ccc(Cl)cc2)c(N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1 10.1016/s0960-894x(02)00382-7
44291515 107915 0 None - 0 Golden hamster 5.3 pIC50 = 5.3 Binding
Binding affinity for NK2 receptor binding sites in membranes prepared from hamster urinary bladder by using [125I]NKA as radioligandBinding affinity for NK2 receptor binding sites in membranes prepared from hamster urinary bladder by using [125I]NKA as radioligand
ChEMBL 580 17 4 5 4.6 CC(C)(C)OC(=O)N[C@@](C)(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCCCCCCC(N)=O 10.1016/S0960-894X(00)80360-1
CHEMBL295301 107915 0 None - 0 Golden hamster 5.3 pIC50 = 5.3 Binding
Binding affinity for NK2 receptor binding sites in membranes prepared from hamster urinary bladder by using [125I]NKA as radioligandBinding affinity for NK2 receptor binding sites in membranes prepared from hamster urinary bladder by using [125I]NKA as radioligand
ChEMBL 580 17 4 5 4.6 CC(C)(C)OC(=O)N[C@@](C)(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCCCCCCC(N)=O 10.1016/S0960-894X(00)80360-1
44305544 209853 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 582 5 1 2 8.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)NC2CCCCC2)ccc1-c1ccc(Cl)cc1 10.1016/s0960-894x(02)00382-7
CHEMBL63785 209853 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 582 5 1 2 8.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)NC2CCCCC2)ccc1-c1ccc(Cl)cc1 10.1016/s0960-894x(02)00382-7
5362440 16793 63 None - 1 Human 5.3 pIC50 = 5.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 613 11 4 7 2.9 CC(C)(C)NC(=O)[C@@H]1CN(Cc2cccnc2)CCN1C[C@@H](O)C[C@@H](Cc1ccccc1)C(=O)N[C@H]1c2ccccc2C[C@H]1O nan
CHEMBL115 16793 63 None - 1 Human 5.3 pIC50 = 5.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 613 11 4 7 2.9 CC(C)(C)NC(=O)[C@@H]1CN(Cc2cccnc2)CCN1C[C@@H](O)C[C@@H](Cc1ccccc1)C(=O)N[C@H]1c2ccccc2C[C@H]1O nan
10907460 16600 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Binding affinity against tachykinin receptor 2Binding affinity against tachykinin receptor 2
ChEMBL 521 11 1 3 5.8 CCOc1ccc(CCNC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 10.1021/jm010878g
CHEMBL113956 16600 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Binding affinity against tachykinin receptor 2Binding affinity against tachykinin receptor 2
ChEMBL 521 11 1 3 5.8 CCOc1ccc(CCNC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 10.1021/jm010878g
CHEMBL2372444 217024 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O 10.1021/jm00037a009
44281769 116437 7 None - 0 Golden hamster 5.3 pIC50 = 5.3 Binding
Binding affinity towards Tachykinin receptor 2 using [125I]iodohistidyl-NKA (0.1 nM)) as radioligandBinding affinity towards Tachykinin receptor 2 using [125I]iodohistidyl-NKA (0.1 nM)) as radioligand
ChEMBL 484 10 4 4 3.2 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1 10.1016/0960-894X(95)00254-Q
CHEMBL32248 116437 7 None - 0 Golden hamster 5.3 pIC50 = 5.3 Binding
Binding affinity towards Tachykinin receptor 2 using [125I]iodohistidyl-NKA (0.1 nM)) as radioligandBinding affinity towards Tachykinin receptor 2 using [125I]iodohistidyl-NKA (0.1 nM)) as radioligand
ChEMBL 484 10 4 4 3.2 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1 10.1016/0960-894X(95)00254-Q
44345938 18775 0 None - 0 Golden hamster 5.3 pIC50 = 5.3 Binding
Tested for binding affinity of compound against [125I]NKA binding to neurokinin-2 (NK-2) receptor in hamster urinary bladderTested for binding affinity of compound against [125I]NKA binding to neurokinin-2 (NK-2) receptor in hamster urinary bladder
ChEMBL 350 7 4 3 1.3 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12 10.1016/S0960-894X(96)00570-7
CHEMBL118328 18775 0 None - 0 Golden hamster 5.3 pIC50 = 5.3 Binding
Tested for binding affinity of compound against [125I]NKA binding to neurokinin-2 (NK-2) receptor in hamster urinary bladderTested for binding affinity of compound against [125I]NKA binding to neurokinin-2 (NK-2) receptor in hamster urinary bladder
ChEMBL 350 7 4 3 1.3 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12 10.1016/S0960-894X(96)00570-7
44212281 137394 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 609 9 1 5 5.7 COc1cccc(OC)c1C(=O)N1CCC(CCN2CCC(C(N)=O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/0960-894X(96)00148-5
CHEMBL368159 137394 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 609 9 1 5 5.7 COc1cccc(OC)c1C(=O)N1CCC(CCN2CCC(C(N)=O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/0960-894X(96)00148-5
CHEMBL2114442 216033 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)[C@@H]1CCc2ccccc21)C(N)=O 10.1021/jm00037a009
44190762 183659 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of radioligand from tachykinin NK2 receptorDisplacement of radioligand from tachykinin NK2 receptor
ChEMBL 531 8 1 5 6.6 Cc1c(C(=O)c2ccc(Cl)cc2)c2ccc(OC(F)(F)F)cc2n1Cc1cccc(O[C@H](C)C(=O)O)c1 10.1016/j.bmcl.2008.07.103
CHEMBL461571 183659 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of radioligand from tachykinin NK2 receptorDisplacement of radioligand from tachykinin NK2 receptor
ChEMBL 531 8 1 5 6.6 Cc1c(C(=O)c2ccc(Cl)cc2)c2ccc(OC(F)(F)F)cc2n1Cc1cccc(O[C@H](C)C(=O)O)c1 10.1016/j.bmcl.2008.07.103
44386105 138708 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 621 10 1 4 6.4 CC(C)Oc1cccc(CC(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/0960-894X(96)00148-5
CHEMBL369498 138708 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 621 10 1 4 6.4 CC(C)Oc1cccc(CC(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/0960-894X(96)00148-5
44335360 11637 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 608 8 2 4 5.5 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(CCC(=O)N[C@@H]1CCCCNC1=O)Cc1ccc2ccccc2c1 10.1016/s0960-894x(01)00631-x
CHEMBL104348 11637 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 608 8 2 4 5.5 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(CCC(=O)N[C@@H]1CCCCNC1=O)Cc1ccc2ccccc2c1 10.1016/s0960-894x(01)00631-x
10077113 128321 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(/C=C/C(=O)NC1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
CHEMBL35857 128321 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(/C=C/C(=O)NC1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
44385575 66570 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 653 11 1 6 5.6 COc1cc(CC(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/0960-894X(96)00148-5
CHEMBL172676 66570 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 653 11 1 6 5.6 COc1cc(CC(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/0960-894X(96)00148-5
44411637 146058 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of human NK2 receptor expressed in CHO cellsInhibition of human NK2 receptor expressed in CHO cells
ChEMBL 441 4 1 3 4.5 O=C(CC1CCN(C(=O)c2cccc(C#Cc3ccccn3)c2)CC1)Nc1ccccc1F 10.1016/j.bmcl.2006.02.027
CHEMBL379097 146058 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of human NK2 receptor expressed in CHO cellsInhibition of human NK2 receptor expressed in CHO cells
ChEMBL 441 4 1 3 4.5 O=C(CC1CCN(C(=O)c2cccc(C#Cc3ccccn3)c2)CC1)Nc1ccccc1F 10.1016/j.bmcl.2006.02.027
10076881 169695 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 577 5 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)NC2CCCCNC2=O)ccc1-c1ccccc1 10.1016/s0960-894x(02)00382-7
CHEMBL417407 169695 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 577 5 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)NC2CCCCNC2=O)ccc1-c1ccccc1 10.1016/s0960-894x(02)00382-7
10055770 124254 0 None - 0 Golden hamster 5.3 pIC50 = 5.3 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 734 24 10 10 -1.7 CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(N)=O 10.1021/jm00099a024
CHEMBL339941 124254 0 None - 0 Golden hamster 5.3 pIC50 = 5.3 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 734 24 10 10 -1.7 CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(N)=O 10.1021/jm00099a024
CHEMBL2114443 216034 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)[C@@H]1CCc2ccccc21)C(N)=O 10.1021/jm00037a009
44319355 112299 0 None - 0 Mouse 7.2 pIC50 = 7.2 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 605 10 1 6 5.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)cc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL312173 112299 0 None - 0 Mouse 7.2 pIC50 = 7.2 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 605 10 1 6 5.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)cc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
71450949 86324 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 567 7 2 4 5.6 CSN1CC2(CCN(C(=O)N[C@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
CHEMBL2114103 86324 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 567 7 2 4 5.6 CSN1CC2(CCN(C(=O)N[C@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
11790 106263 98 None -2 4 Human 5.2 pIC50 = 5.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 272 1 0 2 4.6 O=c1cc(-c2ccccc2)oc2c1ccc1ccccc12 nan
CHEMBL283196 106263 98 None -2 4 Human 5.2 pIC50 = 5.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 272 1 0 2 4.6 O=c1cc(-c2ccccc2)oc2c1ccc1ccccc12 nan
73265456 133228 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 590 4 1 3 5.7 CN(C(=O)N(C)[C@@H]1CN(C(=O)NC2CCOCC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL3651895 133228 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 590 4 1 3 5.7 CN(C(=O)N(C)[C@@H]1CN(C(=O)NC2CCOCC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
71461705 86393 0 None - 0 Guinea pig 7.2 pIC50 = 7.2 Binding
The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membrane
ChEMBL 672 8 0 7 6.0 COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[S@@+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(00)00324-3
CHEMBL2114963 86393 0 None - 0 Guinea pig 7.2 pIC50 = 7.2 Binding
The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membrane
ChEMBL 672 8 0 7 6.0 COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[S@@+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(00)00324-3
9916195 127277 3 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligandBinding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand
ChEMBL 576 7 1 4 5.0 CN(C)C(=O)NC1(c2ccccc2)CCN(CC[C@@]2(c3ccc(F)c(F)c3)CN(C(=O)c3ccccc3)CCO2)CC1 10.1016/s0960-894x(01)00074-9
CHEMBL354422 127277 3 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligandBinding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand
ChEMBL 576 7 1 4 5.0 CN(C)C(=O)NC1(c2ccccc2)CCN(CC[C@@]2(c3ccc(F)c(F)c3)CN(C(=O)c3ccccc3)CCO2)CC1 10.1016/s0960-894x(01)00074-9
CHEMBL126294 215446 19 None - 0 Golden hamster 8.2 pIC50 = 8.2 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(N)=O 10.1021/jm00099a024
44310284 211155 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 465 7 0 4 3.7 O=C(CC1CC1)N1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(03)00343-3
CHEMBL71784 211155 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 465 7 0 4 3.7 O=C(CC1CC1)N1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(03)00343-3
44310102 211172 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 418 7 0 2 5.7 CN(CC(CCN1CCCCC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
CHEMBL71918 211172 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 418 7 0 2 5.7 CN(CC(CCN1CCCCC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
10950925 136432 0 None - 1 Human 8.2 pIC50 = 8.2 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 478 7 1 4 3.8 NC1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL367348 136432 0 None - 1 Human 8.2 pIC50 = 8.2 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 478 7 1 4 3.8 NC1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
44309946 210696 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 434 7 1 3 4.7 CN(CC(CCN1CCC(O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
CHEMBL69065 210696 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 434 7 1 3 4.7 CN(CC(CCN1CCC(O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
23294208 103923 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor
ChEMBL 590 8 1 4 6.8 O=C1CCC(CCCN2CCC(n3c(=O)[nH]c4ccccc43)CC2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1016/s0960-894x(98)00215-7
CHEMBL26790 103923 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor
ChEMBL 590 8 1 4 6.8 O=C1CCC(CCCN2CCC(n3c(=O)[nH]c4ccccc43)CC2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1016/s0960-894x(98)00215-7
44310237 110560 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 517 7 0 5 4.2 COc1ccccc1C(=O)N1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(03)00343-3
CHEMBL308901 110560 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 517 7 0 5 4.2 COc1ccccc1C(=O)N1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(03)00343-3
44309945 109844 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 500 8 2 4 4.9 CN(CC(CCN1CCC(O)(c2ncc[nH]2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
CHEMBL307338 109844 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 500 8 2 4 4.9 CN(CC(CCN1CCC(O)(c2ncc[nH]2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
44310282 210862 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 523 7 0 5 3.7 O=S(=O)(c1ccccc1)N1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(03)00343-3
CHEMBL70157 210862 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 523 7 0 5 3.7 O=S(=O)(c1ccccc1)N1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(03)00343-3
10394084 126622 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity was determined against human NK2 receptor in CHO cells using [125I]neurokinin A as radioligandBinding affinity was determined against human NK2 receptor in CHO cells using [125I]neurokinin A as radioligand
ChEMBL 618 9 1 5 7.4 CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cccc(C2(C(F)(F)F)N=N2)c1 10.1016/0960-894X(96)00075-3
CHEMBL348599 126622 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity was determined against human NK2 receptor in CHO cells using [125I]neurokinin A as radioligandBinding affinity was determined against human NK2 receptor in CHO cells using [125I]neurokinin A as radioligand
ChEMBL 618 9 1 5 7.4 CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cccc(C2(C(F)(F)F)N=N2)c1 10.1016/0960-894X(96)00075-3
44310456 109551 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 485 8 0 5 5.2 CN(CC(CCN1CCC(n2cncn2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
CHEMBL305191 109551 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 485 8 0 5 5.2 CN(CC(CCN1CCC(n2cncn2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
44310433 211139 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 456 8 0 4 5.0 CN(CC(CCN1CC(n2ccnc2)C1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
CHEMBL71704 211139 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 456 8 0 4 5.0 CN(CC(CCN1CC(n2ccnc2)C1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
11498370 107953 0 None - 0 Guinea pig 8.2 pIC50 = 8.2 Binding
The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membrane
ChEMBL 654 8 1 7 5.7 COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[C@@H]4O)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(00)00324-3
CHEMBL295615 107953 0 None - 0 Guinea pig 8.2 pIC50 = 8.2 Binding
The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membrane
ChEMBL 654 8 1 7 5.7 COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[C@@H]4O)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(00)00324-3
44386231 68154 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 607 8 1 4 6.3 COc1c(C)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1C 10.1016/0960-894X(96)00148-5
CHEMBL176951 68154 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 607 8 1 4 6.3 COc1c(C)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1C 10.1016/0960-894X(96)00148-5
44335372 11546 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 605 7 2 3 5.9 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc2ccccc2c1 10.1016/s0960-894x(01)00631-x
CHEMBL103979 11546 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 605 7 2 3 5.9 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc2ccccc2c1 10.1016/s0960-894x(01)00631-x
CHEMBL2372517 217045 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(c1ccccc1)c1ccccc1)C(N)=O 10.1021/jm00037a009
3198 212292 76 None -21 34 Human 5.2 pIC50 = 5.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
CHEMBL1201049 212292 76 None -21 34 Human 5.2 pIC50 = 5.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
CHEMBL808 212292 76 None -21 34 Human 5.2 pIC50 = 5.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
138106885 173690 75 None -1 4 Human 5.2 pIC50 = 5.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 853 10 4 14 3.7 CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C nan
36314 173690 75 None -1 4 Human 5.2 pIC50 = 5.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 853 10 4 14 3.7 CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C nan
CHEMBL428647 173690 75 None -1 4 Human 5.2 pIC50 = 5.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 853 10 4 14 3.7 CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C nan
44291788 108189 0 None - 0 Golden hamster 5.2 pIC50 = 5.2 Binding
Binding affinity for NK2 receptor binding sites in membranes prepared from hamster urinary bladder by using [125I]NKA as radioligandBinding affinity for NK2 receptor binding sites in membranes prepared from hamster urinary bladder by using [125I]NKA as radioligand
ChEMBL 553 16 4 5 4.7 CC(C)(C)OC(=O)N[C@@](C)(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCCCCCCO 10.1016/S0960-894X(00)80360-1
CHEMBL297327 108189 0 None - 0 Golden hamster 5.2 pIC50 = 5.2 Binding
Binding affinity for NK2 receptor binding sites in membranes prepared from hamster urinary bladder by using [125I]NKA as radioligandBinding affinity for NK2 receptor binding sites in membranes prepared from hamster urinary bladder by using [125I]NKA as radioligand
ChEMBL 553 16 4 5 4.7 CC(C)(C)OC(=O)N[C@@](C)(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCCCCCCO 10.1016/S0960-894X(00)80360-1
44291015 108004 2 None - 0 Golden hamster 5.2 pIC50 = 5.2 Binding
Inhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKAInhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKA
ChEMBL 553 16 4 5 4.7 CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@](C)(Cc1ccccc1)C(=O)NCCCCCCCCO 10.1021/jm950892r
CHEMBL296014 108004 2 None - 0 Golden hamster 5.2 pIC50 = 5.2 Binding
Inhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKAInhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKA
ChEMBL 553 16 4 5 4.7 CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@](C)(Cc1ccccc1)C(=O)NCCCCCCCCO 10.1021/jm950892r
441243 16608 58 None -19 8 Human 5.2 pIC50 = 5.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 670 12 5 7 3.1 CC(C)(C)NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2CN1C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)c1ccc2ccccc2n1 nan
CHEMBL114 16608 58 None -19 8 Human 5.2 pIC50 = 5.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 670 12 5 7 3.1 CC(C)(C)NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2CN1C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)c1ccc2ccccc2n1 nan
CHEMBL307433 217759 0 None - 0 Golden hamster 6.2 pIC50 = 6.2 Binding
Concentration producing half-maximal inhibition of specific binding of. [125I]neurokinin A to NK-2 receptors in the hamster urinary bladderConcentration producing half-maximal inhibition of specific binding of. [125I]neurokinin A to NK-2 receptors in the hamster urinary bladder
ChEMBL None None None CCCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(C)=O)C(N)=O 10.1016/0960-894X(94)85022-4
10055415 113533 0 None - 3 Human 7.2 pIC50 = 7.2 Binding
Tested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligand
ChEMBL 688 12 4 5 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144352 113533 0 None - 3 Human 7.2 pIC50 = 7.2 Binding
Tested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligand
ChEMBL 688 12 4 5 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
10055415 113533 0 None - 3 Rat 7.2 pIC50 = 7.2 Binding
Tested for binding affinity against rat NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for binding affinity against rat NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligand
ChEMBL 688 12 4 5 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144352 113533 0 None - 3 Rat 7.2 pIC50 = 7.2 Binding
Tested for binding affinity against rat NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for binding affinity against rat NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligand
ChEMBL 688 12 4 5 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
2125 9804 2 None - 1 Golden hamster 5.2 pIC50 = 5.2 Binding
Binding affinity for NK2 receptor binding sites in membranes prepared from hamster urinary bladder by using [125I]NKA as radioligandBinding affinity for NK2 receptor binding sites in membranes prepared from hamster urinary bladder by using [125I]NKA as radioligand
ChEMBL 581 16 5 5 4.0 NC(=O)NCCCCCCCNC(=O)[C@@](Cc1ccccc1)(NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C 10.1016/S0960-894X(00)80360-1
5311350 9804 2 None - 1 Golden hamster 5.2 pIC50 = 5.2 Binding
Binding affinity for NK2 receptor binding sites in membranes prepared from hamster urinary bladder by using [125I]NKA as radioligandBinding affinity for NK2 receptor binding sites in membranes prepared from hamster urinary bladder by using [125I]NKA as radioligand
ChEMBL 581 16 5 5 4.0 NC(=O)NCCCCCCCNC(=O)[C@@](Cc1ccccc1)(NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C 10.1016/S0960-894X(00)80360-1
CHEMBL444832 9804 2 None - 1 Golden hamster 5.2 pIC50 = 5.2 Binding
Binding affinity for NK2 receptor binding sites in membranes prepared from hamster urinary bladder by using [125I]NKA as radioligandBinding affinity for NK2 receptor binding sites in membranes prepared from hamster urinary bladder by using [125I]NKA as radioligand
ChEMBL 581 16 5 5 4.0 NC(=O)NCCCCCCCNC(=O)[C@@](Cc1ccccc1)(NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C 10.1016/S0960-894X(00)80360-1
2125 9804 2 None - 1 Golden hamster 5.2 pIC50 = 5.2 Binding
Inhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKAInhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKA
ChEMBL 581 16 5 5 4.0 NC(=O)NCCCCCCCNC(=O)[C@@](Cc1ccccc1)(NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C 10.1021/jm950892r
5311350 9804 2 None - 1 Golden hamster 5.2 pIC50 = 5.2 Binding
Inhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKAInhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKA
ChEMBL 581 16 5 5 4.0 NC(=O)NCCCCCCCNC(=O)[C@@](Cc1ccccc1)(NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C 10.1021/jm950892r
CHEMBL444832 9804 2 None - 1 Golden hamster 5.2 pIC50 = 5.2 Binding
Inhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKAInhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKA
ChEMBL 581 16 5 5 4.0 NC(=O)NCCCCCCCNC(=O)[C@@](Cc1ccccc1)(NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C 10.1021/jm950892r
44335318 11877 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 603 8 2 3 5.9 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NC1(C(N)=O)CCCCC1)Cc1ccc(Cl)cc1 10.1016/s0960-894x(01)00631-x
CHEMBL105600 11877 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 603 8 2 3 5.9 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NC1(C(N)=O)CCCCC1)Cc1ccc(Cl)cc1 10.1016/s0960-894x(01)00631-x
49863733 22104 0 None -2 4 Rat 6.2 pIC50 = 6.2 Binding
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 1477 21 11 14 6.8 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm100157m
CHEMBL1214026 22104 0 None -2 4 Rat 6.2 pIC50 = 6.2 Binding
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 1477 21 11 14 6.8 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm100157m
CHEMBL410808 219622 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(c1ccccc1)c1ccccc1)C(N)=O 10.1021/jm00037a009
657255 205863 34 None -17 15 Human 5.2 pIC50 = 5.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 337 12 2 3 5.6 CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1 nan
CHEMBL588119 205863 34 None -17 15 Human 5.2 pIC50 = 5.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 337 12 2 3 5.6 CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1 nan
CHEMBL405422 219340 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(C)(C)SC)C(N)=O 10.1021/jm00037a009
3040489 51335 2 None - 0 Golden hamster 5.2 pIC50 = 5.2 Binding
Binding affinity towards Tachykinin receptor 2 in hamster urinary bladder using [125I]neurokinin A as radioligand; Value ranges from 4.6-9.0 uMBinding affinity towards Tachykinin receptor 2 in hamster urinary bladder using [125I]neurokinin A as radioligand; Value ranges from 4.6-9.0 uM
ChEMBL 318 4 1 2 3.8 O=C1CCN(Cc2ccccc2)CC1Cc1c[nH]c2ccccc12 10.1016/0960-894X(94)80030-8
CHEMBL151990 51335 2 None - 0 Golden hamster 5.2 pIC50 = 5.2 Binding
Binding affinity towards Tachykinin receptor 2 in hamster urinary bladder using [125I]neurokinin A as radioligand; Value ranges from 4.6-9.0 uMBinding affinity towards Tachykinin receptor 2 in hamster urinary bladder using [125I]neurokinin A as radioligand; Value ranges from 4.6-9.0 uM
ChEMBL 318 4 1 2 3.8 O=C1CCN(Cc2ccccc2)CC1Cc1c[nH]c2ccccc12 10.1016/0960-894X(94)80030-8
CHEMBL264353 217397 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1c2ccccc2-c2ccccc21)C(N)=O 10.1021/jm00037a009
44366600 49706 0 None - 0 Golden hamster 5.2 pIC50 = 5.2 Binding
Binding affinity towards Tachykinin receptor 2 in hamster urinary bladder using [125I]neurokinin A as radioligand; Value ranges from 2.6-11 uMBinding affinity towards Tachykinin receptor 2 in hamster urinary bladder using [125I]neurokinin A as radioligand; Value ranges from 2.6-11 uM
ChEMBL 360 5 1 2 3.8 O=C1CCN(C(=O)CCc2c[nH]c3ccccc23)CC1Cc1ccccc1 10.1016/0960-894X(94)80030-8
CHEMBL150346 49706 0 None - 0 Golden hamster 5.2 pIC50 = 5.2 Binding
Binding affinity towards Tachykinin receptor 2 in hamster urinary bladder using [125I]neurokinin A as radioligand; Value ranges from 2.6-11 uMBinding affinity towards Tachykinin receptor 2 in hamster urinary bladder using [125I]neurokinin A as radioligand; Value ranges from 2.6-11 uM
ChEMBL 360 5 1 2 3.8 O=C1CCN(C(=O)CCc2c[nH]c3ccccc23)CC1Cc1ccccc1 10.1016/0960-894X(94)80030-8
135449286 199968 2 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 502 6 2 5 4.3 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm950654w
CHEMBL52330 199968 2 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 502 6 2 5 4.3 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm950654w
44212285 130596 1 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 549 7 1 3 5.7 NC(=O)C1(c2ccccc2)CCN(CCC2(c3ccc(Cl)c(Cl)c3)CCN(C(=O)c3ccccc3)C2)CC1 10.1016/0960-894X(96)00148-5
CHEMBL362394 130596 1 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 549 7 1 3 5.7 NC(=O)C1(c2ccccc2)CCN(CCC2(c3ccc(Cl)c(Cl)c3)CCN(C(=O)c3ccccc3)C2)CC1 10.1016/0960-894X(96)00148-5
73265450 133220 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 680 4 0 3 7.2 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3651887 133220 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 680 4 0 3 7.2 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
87318292 133230 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 616 4 0 3 5.6 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3)[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
CHEMBL3651897 133230 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 616 4 0 3 5.6 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3)[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
44310105 211081 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 550 8 1 5 6.6 CN(CC(CCN1CCCC(n2c(O)nc3ccccc32)C1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
CHEMBL71394 211081 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 550 8 1 5 6.6 CN(CC(CCN1CCCC(n2c(O)nc3ccccc32)C1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
44310432 211132 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 473 6 0 4 3.8 O=C(c1ccccc1)N1CC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(03)00343-3
CHEMBL71644 211132 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 473 6 0 4 3.8 O=C(c1ccccc1)N1CC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(03)00343-3
44310150 109485 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 534 8 1 3 7.0 CN(CC(CCN1CCC(c2nc3ccccc3[nH]2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
CHEMBL304807 109485 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 534 8 1 3 7.0 CN(CC(CCN1CCC(c2nc3ccccc3[nH]2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
44310262 211052 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 536 8 1 5 6.2 CN(CC(CCN1CCC(n2c(O)nc3ccccc32)C1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
CHEMBL71226 211052 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 536 8 1 5 6.2 CN(CC(CCN1CCC(n2c(O)nc3ccccc32)C1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
44310238 210823 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 487 6 0 4 4.2 O=C(c1ccccc1)N1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(03)00343-3
CHEMBL69889 210823 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 487 6 0 4 4.2 O=C(c1ccccc1)N1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(03)00343-3
44310165 210673 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 484 8 0 4 5.8 CN(CC(CCN1CCC(n2ccnc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
CHEMBL68917 210673 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 484 8 0 4 5.8 CN(CC(CCN1CCC(n2ccnc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
10005190 211133 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 475 8 0 4 4.3 CN(CC(CCN1CC(N2CCOCC2)C1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
CHEMBL71647 211133 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 475 8 0 4 4.3 CN(CC(CCN1CC(N2CCOCC2)C1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
44319323 20519 0 None - 0 Mouse 8.1 pIC50 = 8.1 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL1195230 20519 0 None - 0 Mouse 8.1 pIC50 = 8.1 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL554092 20519 0 None - 0 Mouse 8.1 pIC50 = 8.1 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
9807403 73458 0 None - 1 Human 8.1 pIC50 = 8.1 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 542 8 0 5 2.9 CS(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL185452 73458 0 None - 1 Human 8.1 pIC50 = 8.1 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 542 8 0 5 2.9 CS(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
44392347 128906 0 None - 1 Human 8.1 pIC50 = 8.1 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 543 7 0 4 5.1 O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCC(F)(F)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL359655 128906 0 None - 1 Human 8.1 pIC50 = 8.1 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 543 7 0 4 5.1 O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCC(F)(F)CC1 10.1016/j.bmcl.2005.05.134
71449143 86295 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 611 5 2 3 6.7 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)N[C@@H]2CCCCNC2=O)ccc1-c1ccc(Cl)cc1 10.1016/s0960-894x(02)00382-7
CHEMBL2113740 86295 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 611 5 2 3 6.7 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)N[C@@H]2CCCCNC2=O)ccc1-c1ccc(Cl)cc1 10.1016/s0960-894x(02)00382-7
CHEMBL2371928 216933 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity to NK2 receptorBinding affinity to NK2 receptor
ChEMBL None None None CC(C)CC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CC(=O)NC(=O)N1)C(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)N[C@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2006.07.036
25028925 98140 4 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor
ChEMBL 570 5 1 5 5.5 Cc1ccccc1[C@@H]1[C@@H](O[C@H](CO)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H]2CN(C3=NC(=O)CO3)C[C@H]21 10.1021/jm400751p
CHEMBL2402572 98140 4 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor
ChEMBL 570 5 1 5 5.5 Cc1ccccc1[C@@H]1[C@@H](O[C@H](CO)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H]2CN(C3=NC(=O)CO3)C[C@H]21 10.1021/jm400751p
CHEMBL2369630 216424 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Tested for binding affinity against Tachykinin receptor 2 expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against Tachykinin receptor 2 expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None C[C@H](NC(=O)CN)C(=O)N[C@H]1CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O 10.1021/jm000316h
44212283 66633 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 593 9 1 4 5.6 COc1ccccc1CC(=O)N1CCC(CCN2CCC(C(N)=O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/0960-894X(96)00148-5
CHEMBL172915 66633 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 593 9 1 4 5.6 COc1ccccc1CC(=O)N1CCC(CCN2CCC(C(N)=O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/0960-894X(96)00148-5
44319356 111148 0 None - 0 Mouse 7.1 pIC50 = 7.1 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 607 10 1 6 4.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(F)c(F)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL310173 111148 0 None - 0 Mouse 7.1 pIC50 = 7.1 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 607 10 1 6 4.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(F)c(F)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
73265457 133229 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 653 4 0 4 4.5 CN(C(=O)N(C)[C@@H]1CN(C(=O)N2CCN(S(C)(=O)=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL3651896 133229 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 653 4 0 4 4.5 CN(C(=O)N(C)[C@@H]1CN(C(=O)N2CCN(S(C)(=O)=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
10439730 113534 0 None - 3 Human 7.1 pIC50 = 7.1 Binding
Tested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligand
ChEMBL 702 12 3 6 3.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144353 113534 0 None - 3 Human 7.1 pIC50 = 7.1 Binding
Tested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligand
ChEMBL 702 12 3 6 3.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
10972666 129724 0 None - 1 Human 7.1 pIC50 = 7.1 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 465 7 0 4 3.7 O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1 10.1016/j.bmcl.2005.05.134
CHEMBL360721 129724 0 None - 1 Human 7.1 pIC50 = 7.1 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 465 7 0 4 3.7 O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1 10.1016/j.bmcl.2005.05.134
9915428 180412 3 None - 0 Golden hamster 6.1 pIC50 = 6.1 Binding
Compound was tested for binding affinity towards Tachykinin receptor 2 binding sites in membranes prepared from hamster urinary bladder using [125I]neurokinin A as radioligandCompound was tested for binding affinity towards Tachykinin receptor 2 binding sites in membranes prepared from hamster urinary bladder using [125I]neurokinin A as radioligand
ChEMBL 546 15 4 4 5.1 CC(C)[C@H](OC(=O)N[C@](C)(Cc1cccc(F)c1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 10.1016/0960-894X(95)00313-I
CHEMBL45340 180412 3 None - 0 Golden hamster 6.1 pIC50 = 6.1 Binding
Compound was tested for binding affinity towards Tachykinin receptor 2 binding sites in membranes prepared from hamster urinary bladder using [125I]neurokinin A as radioligandCompound was tested for binding affinity towards Tachykinin receptor 2 binding sites in membranes prepared from hamster urinary bladder using [125I]neurokinin A as radioligand
ChEMBL 546 15 4 4 5.1 CC(C)[C@H](OC(=O)N[C@](C)(Cc1cccc(F)c1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 10.1016/0960-894X(95)00313-I
9915428 180412 3 None - 0 Golden hamster 6.1 pIC50 = 6.1 Binding
Inhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKAInhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKA
ChEMBL 546 15 4 4 5.1 CC(C)[C@H](OC(=O)N[C@](C)(Cc1cccc(F)c1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 10.1021/jm950892r
CHEMBL45340 180412 3 None - 0 Golden hamster 6.1 pIC50 = 6.1 Binding
Inhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKAInhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKA
ChEMBL 546 15 4 4 5.1 CC(C)[C@H](OC(=O)N[C@](C)(Cc1cccc(F)c1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 10.1021/jm950892r
44310151 109555 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 534 8 0 4 6.9 CN(CC(CCN1CCC(n2cnc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
CHEMBL305236 109555 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 534 8 0 4 6.9 CN(CC(CCN1CCC(n2cnc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
153996 119445 2 None -3 3 Human 8.1 pIC50 = 8.1 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/0960-894X(96)00148-5
CHEMBL330366 119445 2 None -3 3 Human 8.1 pIC50 = 8.1 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/0960-894X(96)00148-5
CHEMBL539021 119445 2 None -3 3 Human 8.1 pIC50 = 8.1 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/0960-894X(96)00148-5
153996 119445 2 None - 3 Mouse 8.1 pIC50 = 8.1 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL330366 119445 2 None - 3 Mouse 8.1 pIC50 = 8.1 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL539021 119445 2 None - 3 Mouse 8.1 pIC50 = 8.1 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
44310139 211489 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 564 8 1 5 7.0 CN(CC(CCN1CCCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
CHEMBL74127 211489 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 564 8 1 5 7.0 CN(CC(CCN1CCCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
9831309 142042 1 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory concentration against tachykinin receptor 2Inhibitory concentration against tachykinin receptor 2
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1021/jm058225d
CHEMBL372587 142042 1 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory concentration against tachykinin receptor 2Inhibitory concentration against tachykinin receptor 2
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1021/jm058225d
21831101 210600 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 550 8 1 5 6.6 CN(CC(CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
CHEMBL68440 210600 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 550 8 1 5 6.6 CN(CC(CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
18964186 211083 0 None - 3 Human 8.1 pIC50 = 8.1 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 510 8 1 3 6.2 CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
CHEMBL71397 211083 0 None - 3 Human 8.1 pIC50 = 8.1 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 510 8 1 3 6.2 CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
9850582 204021 22 None -1 6 Human 8.1 pIC50 = 8.1 Binding
Binding affinity towards human Tachykinin receptor 2 using [125I]- NKA radioligand expressed in CHO cellsBinding affinity towards human Tachykinin receptor 2 using [125I]- NKA radioligand expressed in CHO cells
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(03)00343-3
CHEMBL56835 204021 22 None -1 6 Human 8.1 pIC50 = 8.1 Binding
Binding affinity towards human Tachykinin receptor 2 using [125I]- NKA radioligand expressed in CHO cellsBinding affinity towards human Tachykinin receptor 2 using [125I]- NKA radioligand expressed in CHO cells
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(03)00343-3
21121353 108250 0 None - 3 Rat 6.1 pIC50 = 6.1 Binding
Tested for the binding affinity against rat neurokinin-2 (NK-2) receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for the binding affinity against rat neurokinin-2 (NK-2) receptor transfected on CHO cells using [125I]-His] NKA as radioligand
ChEMBL 625 14 4 7 2.0 CC(=O)N[C@H](C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm00063a015
CHEMBL297776 108250 0 None - 3 Rat 6.1 pIC50 = 6.1 Binding
Tested for the binding affinity against rat neurokinin-2 (NK-2) receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for the binding affinity against rat neurokinin-2 (NK-2) receptor transfected on CHO cells using [125I]-His] NKA as radioligand
ChEMBL 625 14 4 7 2.0 CC(=O)N[C@H](C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm00063a015
CHEMBL2369631 216425 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Tested for binding affinity against Tachykinin receptor 2 expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against Tachykinin receptor 2 expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None C[C@H](NC(=O)CN)C(=O)N[C@H]1CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O 10.1021/jm000316h
2683 109665 25 None -398 16 Human 5.1 pIC50 = 5.1 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 304 15 0 0 6.5 CCCCCCCCCCCCCCCC[n+]1ccccc1 nan
CHEMBL305906 109665 25 None -398 16 Human 5.1 pIC50 = 5.1 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 304 15 0 0 6.5 CCCCCCCCCCCCCCCC[n+]1ccccc1 nan
CHEMBL334255 109665 25 None -398 16 Human 5.1 pIC50 = 5.1 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 304 15 0 0 6.5 CCCCCCCCCCCCCCCC[n+]1ccccc1 nan
579 9918 18 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity to NK2 receptorBinding affinity to NK2 receptor
ChEMBL None None None None 10.1016/j.bmcl.2006.07.036
6918468 9918 18 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity to NK2 receptorBinding affinity to NK2 receptor
ChEMBL None None None None 10.1016/j.bmcl.2006.07.036
CHEMBL41547 9918 18 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity to NK2 receptorBinding affinity to NK2 receptor
ChEMBL None None None None 10.1016/j.bmcl.2006.07.036
10259606 124887 0 None - 0 Golden hamster 8.1 pIC50 = 8.1 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 768 24 10 10 -1.5 CC(C)C[C@@H](CN[C@@H](Cc1ccccc1)C(N)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C 10.1021/jm00099a024
CHEMBL340743 124887 0 None - 0 Golden hamster 8.1 pIC50 = 8.1 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 768 24 10 10 -1.5 CC(C)C[C@@H](CN[C@@H](Cc1ccccc1)C(N)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C 10.1021/jm00099a024
CHEMBL263852 217372 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(C)(C)C)C(N)=O 10.1021/jm00037a009
CHEMBL2390989 217190 16 None - 1 Human 8.0 pIC50 = 8.0 Binding
Binding affinity to human NK2 receptor by radioligand displacement assayBinding affinity to human NK2 receptor by radioligand displacement assay
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(N)=O 10.1016/j.ejmech.2013.01.044
44319340 212692 0 None - 0 Mouse 8.0 pIC50 = 8.0 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 707 10 0 6 7.2 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)N4CCCCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL84055 212692 0 None - 0 Mouse 8.0 pIC50 = 8.0 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 707 10 0 6 7.2 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)N4CCCCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
44312000 211458 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 551 8 3 3 4.6 CC(=O)NC1(c2ccccc2)CCN(C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N(C)Cc2ccccc2)CC1 10.1016/s0960-894x(98)00395-3
CHEMBL73839 211458 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 551 8 3 3 4.6 CC(=O)NC1(c2ccccc2)CCN(C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N(C)Cc2ccccc2)CC1 10.1016/s0960-894x(98)00395-3
CHEMBL265573 217433 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)/C(=C\c1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O 10.1021/jm00037a009
448537 167029 89 None -26 25 Human 5.0 pIC50 = 5.0 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 268 4 2 2 4.8 CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 nan
CHEMBL411 167029 89 None -26 25 Human 5.0 pIC50 = 5.0 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 268 4 2 2 4.8 CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 nan
44384678 68145 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 697 11 1 8 6.2 CCOC(=O)Oc1c(OC)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1OC 10.1016/0960-894X(96)00148-5
CHEMBL176860 68145 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 697 11 1 8 6.2 CCOC(=O)Oc1c(OC)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1OC 10.1016/0960-894X(96)00148-5
21121353 108250 0 None - 3 Human 7.0 pIC50 = 7 Binding
Tested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligand
ChEMBL 625 14 4 7 2.0 CC(=O)N[C@H](C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm00063a015
CHEMBL297776 108250 0 None - 3 Human 7.0 pIC50 = 7 Binding
Tested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligand
ChEMBL 625 14 4 7 2.0 CC(=O)N[C@H](C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm00063a015
44270502 62027 0 None - 1 Rat 9.7 pKd = 9.7 Binding
pA2 value against Tachykinin receptor 2 in rat vas deferenspA2 value against Tachykinin receptor 2 in rat vas deferens
ChEMBL 714 6 8 7 -0.3 CC(C)C[C@@H]1NC(=O)[C@@H]2CNC(=O)C[C@H](NC(=O)[C@H](C)CNC1=O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2 10.1016/s0960-894x(98)00178-4
CHEMBL16180 62027 0 None - 1 Rat 9.7 pKd = 9.7 Binding
pA2 value against Tachykinin receptor 2 in rat vas deferenspA2 value against Tachykinin receptor 2 in rat vas deferens
ChEMBL 714 6 8 7 -0.3 CC(C)C[C@@H]1NC(=O)[C@@H]2CNC(=O)C[C@H](NC(=O)[C@H](C)CNC1=O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2 10.1016/s0960-894x(98)00178-4
118718707 122158 0 None - 1 Rat 6.0 pKd = 6 Binding
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 843 12 8 9 0.3 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC1=O)C2=O 10.1021/jm00053a001
CHEMBL3350012 122158 0 None - 1 Rat 6.0 pKd = 6 Binding
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 843 12 8 9 0.3 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC1=O)C2=O 10.1021/jm00053a001
118718415 122129 0 None -2 2 Rat 5.0 pKd = 5 Binding
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 820 12 8 10 -0.5 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC1=O)C2=O 10.1021/jm00053a001
CHEMBL3349511 122129 0 None -2 2 Rat 5.0 pKd = 5 Binding
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 820 12 8 10 -0.5 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC1=O)C2=O 10.1021/jm00053a001
118718693 122154 0 None - 1 Rat 5.0 pKd = 5 Binding
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 843 12 8 9 0.3 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC1=O)C2=O 10.1021/jm00053a001
CHEMBL3349994 122154 0 None - 1 Rat 5.0 pKd = 5 Binding
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 843 12 8 9 0.3 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC1=O)C2=O 10.1021/jm00053a001
118718709 122159 0 None - 1 Rat 5.0 pKd = 5 Binding
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 726 8 5 7 2.5 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@](C)(c3cccc4ccccc34)NC(=O)CNC1=O)C2=O 10.1021/jm00053a001
CHEMBL3350016 122159 0 None - 1 Rat 5.0 pKd = 5 Binding
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 726 8 5 7 2.5 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@](C)(c3cccc4ccccc34)NC(=O)CNC1=O)C2=O 10.1021/jm00053a001
118718515 122138 0 None - 1 Rat 4.9 pKd = 4.9 Binding
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 786 12 7 8 1.2 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCC(N)=O)NC1=O)C2=O 10.1021/jm00053a001
CHEMBL3349686 122138 0 None - 1 Rat 4.9 pKd = 4.9 Binding
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 786 12 7 8 1.2 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCC(N)=O)NC1=O)C2=O 10.1021/jm00053a001
118718571 122145 0 None - 1 Rat 4.8 pKd = 4.8 Binding
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 747 12 6 8 0.7 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CCC(N)=O)NC1=O)C2=O 10.1021/jm00053a001
CHEMBL3349799 122145 0 None - 1 Rat 4.8 pKd = 4.8 Binding
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 747 12 6 8 0.7 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CCC(N)=O)NC1=O)C2=O 10.1021/jm00053a001
CHEMBL3349619 218224 0 None - 1 Rat 4.8 pKd = 4.8 Binding
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL None None None CSCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm00053a001
118718570 122144 0 None 63 2 Rat 6.7 pKd = 6.7 Binding
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 786 12 7 8 1.2 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCC(N)=O)NC1=O)C2=O 10.1021/jm00053a001
CHEMBL3349798 122144 0 None 63 2 Rat 6.7 pKd = 6.7 Binding
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 786 12 7 8 1.2 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCC(N)=O)NC1=O)C2=O 10.1021/jm00053a001
CHEMBL3349990 218243 0 None - 1 Rat 4.7 pKd = 4.7 Binding
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL None None None CSCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm00053a001
118718513 122137 0 None - 1 Rat 5.6 pKd = 5.6 Binding
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 797 11 6 8 2.2 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@](C)(c3cccc4ccccc34)NC(=O)[C@H](CCC(N)=O)NC1=O)C2=O 10.1021/jm00053a001
CHEMBL3349683 122137 0 None - 1 Rat 5.6 pKd = 5.6 Binding
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 797 11 6 8 2.2 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@](C)(c3cccc4ccccc34)NC(=O)[C@H](CCC(N)=O)NC1=O)C2=O 10.1021/jm00053a001
118718694 122155 0 None - 1 Rat 4.6 pKd = 4.6 Binding
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 804 12 7 9 -0.2 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC1=O)C2=O 10.1021/jm00053a001
CHEMBL3349995 122155 0 None - 1 Rat 4.6 pKd = 4.6 Binding
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 804 12 7 9 -0.2 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC1=O)C2=O 10.1021/jm00053a001
118718517 122140 0 None -1 3 Rat 6.4 pKd = 6.4 Binding
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 800 12 6 8 1.5 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)N(C)C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCC(N)=O)NC1=O)C2=O 10.1021/jm00053a001
CHEMBL3349688 122140 0 None -1 3 Rat 6.4 pKd = 6.4 Binding
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 800 12 6 8 1.5 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)N(C)C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCC(N)=O)NC1=O)C2=O 10.1021/jm00053a001
44270503 105554 0 None - 1 Rat 8.3 pKd = 8.3 Binding
pA2 value against Tachykinin receptor 2 in rat vas deferenspA2 value against Tachykinin receptor 2 in rat vas deferens
ChEMBL 908 10 12 13 -2.8 CC(C)C[C@@H]1NC(=O)[C@@H]2CNC(=O)C[C@H](NC(=O)[C@H](CSCC3O[C@@H](O)C(O)[C@H](O)[C@H]3O)CNC1=O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2 10.1016/s0960-894x(98)00178-4
CHEMBL278223 105554 0 None - 1 Rat 8.3 pKd = 8.3 Binding
pA2 value against Tachykinin receptor 2 in rat vas deferenspA2 value against Tachykinin receptor 2 in rat vas deferens
ChEMBL 908 10 12 13 -2.8 CC(C)C[C@@H]1NC(=O)[C@@H]2CNC(=O)C[C@H](NC(=O)[C@H](CSCC3O[C@@H](O)C(O)[C@H](O)[C@H]3O)CNC1=O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2 10.1016/s0960-894x(98)00178-4
CHEMBL334721 218178 1 None -9 3 Rat 8.2 pKd = 8.2 Binding
pA2 value against Tachykinin receptor 2 in rat vas deferenspA2 value against Tachykinin receptor 2 in rat vas deferens
ChEMBL None None None CSCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CNC(=O)C[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2 10.1016/s0960-894x(98)00178-4
CHEMBL3349531 218204 0 None - 1 Rat 6.2 pKd = 6.2 Binding
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL None None None CSCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm00053a001
CHEMBL3349620 218225 11 None 251 3 Rat 8.1 pKd = 8.1 Binding
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL None None None CSCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm00053a001
118718516 122139 0 None -79 3 Rat 5.1 pKd = 5.1 Binding
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 1599 27 12 16 2.8 CC(C)C[C@H]1C(=O)N[C@@H](CCSCCSCC[C@@H]2NC(=O)[C@H](CC(C)C)N3C=C[C@@H](NC(=O)[C@H](Cc4ccccc4)N(C)C(=O)[C@@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCC(N)=O)NC2=O)C3=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@@H]2C=CN1C2=O 10.1021/jm00053a001
CHEMBL3349687 122139 0 None -79 3 Rat 5.1 pKd = 5.1 Binding
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 1599 27 12 16 2.8 CC(C)C[C@H]1C(=O)N[C@@H](CCSCCSCC[C@@H]2NC(=O)[C@H](CC(C)C)N3C=C[C@@H](NC(=O)[C@H](Cc4ccccc4)N(C)C(=O)[C@@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCC(N)=O)NC2=O)C3=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@@H]2C=CN1C2=O 10.1021/jm00053a001
9831504 91811 0 None - 1 Human 10.6 pKi = 10.6 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 696 8 6 6 2.0 O=C1C[C@@H](NC2CC[S+]([O-])CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL224081 91811 0 None - 1 Human 10.6 pKi = 10.6 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 696 8 6 6 2.0 O=C1C[C@@H](NC2CC[S+]([O-])CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
71449111 85670 0 None 6 2 Human 10.3 pKi = 10.3 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 759 8 5 6 3.3 O=C1CC(C(=O)N2CCC(N3CCCCC3)CC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
CHEMBL2112922 85670 0 None 6 2 Human 10.3 pKi = 10.3 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 759 8 5 6 3.3 O=C1CC(C(=O)N2CCC(N3CCCCC3)CC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
44421489 175507 0 None - 1 Human 10.3 pKi = 10.3 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 742 9 7 7 0.8 NS(=O)(=O)N1CCC(N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
CHEMBL436981 175507 0 None - 1 Human 10.3 pKi = 10.3 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 742 9 7 7 0.8 NS(=O)(=O)N1CCC(N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
11433617 13543 0 None - 1 Human 10.3 pKi = 10.3 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 630 12 2 6 5.8 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083850 13543 0 None - 1 Human 10.3 pKi = 10.3 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 630 12 2 6 5.8 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
23625329 99594 0 None - 1 Human 10.3 pKi = 10.3 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 664 11 3 6 5.6 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccc(Cl)cc2s1 10.1021/jm070289w
CHEMBL243711 99594 0 None - 1 Human 10.3 pKi = 10.3 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 664 11 3 6 5.6 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccc(Cl)cc2s1 10.1021/jm070289w
11593070 99944 0 None - 1 Human 10.2 pKi = 10.2 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 708 11 3 6 5.7 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccc(Br)cc2s1 10.1021/jm070289w
CHEMBL244362 99944 0 None - 1 Human 10.2 pKi = 10.2 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 708 11 3 6 5.7 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccc(Br)cc2s1 10.1021/jm070289w
23627059 157955 0 None - 1 Human 10.2 pKi = 10.2 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 698 11 3 6 5.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccc(C(F)(F)F)cc2s1 10.1021/jm070289w
CHEMBL395972 157955 0 None - 1 Human 10.2 pKi = 10.2 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 698 11 3 6 5.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccc(C(F)(F)F)cc2s1 10.1021/jm070289w
11366268 148783 0 None - 1 Human 10.2 pKi = 10.2 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 664 8 6 6 2.3 O=C1C[C@@H](NC2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL387506 148783 0 None - 1 Human 10.2 pKi = 10.2 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 664 8 6 6 2.3 O=C1C[C@@H](NC2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
44421488 175789 0 None - 1 Human 10.2 pKi = 10.2 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 741 9 6 7 1.6 CS(=O)(=O)N1CCC(N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
CHEMBL439281 175789 0 None - 1 Human 10.2 pKi = 10.2 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 741 9 6 7 1.6 CS(=O)(=O)N1CCC(N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
11527495 8749 19 None - 1 Human 10.1 pKi = 10.1 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 644 11 3 6 5.2 O=C([C@H](NC(=O)C1(CCCC1)NC(=O)c1cc2c(s1)cc(cc2)C)Cc1ccccc1)NCC1CCN(CC1)CC1CCOCC1 10.1021/jm070289w
2117 8749 19 None - 1 Human 10.1 pKi = 10.1 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 644 11 3 6 5.2 O=C([C@H](NC(=O)C1(CCCC1)NC(=O)c1cc2c(s1)cc(cc2)C)Cc1ccccc1)NCC1CCN(CC1)CC1CCOCC1 10.1021/jm070289w
CHEMBL266125 8749 19 None - 1 Human 10.1 pKi = 10.1 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 644 11 3 6 5.2 O=C([C@H](NC(=O)C1(CCCC1)NC(=O)c1cc2c(s1)cc(cc2)C)Cc1ccccc1)NCC1CCN(CC1)CC1CCOCC1 10.1021/jm070289w
DB12042 8749 19 None - 1 Human 10.1 pKi = 10.1 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 644 11 3 6 5.2 O=C([C@H](NC(=O)C1(CCCC1)NC(=O)c1cc2c(s1)cc(cc2)C)Cc1ccccc1)NCC1CCN(CC1)CC1CCOCC1 10.1021/jm070289w
46889641 13551 0 None - 1 Human 10.1 pKi = 10.1 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 602 10 2 6 5.2 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCN4CCN(C5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083858 13551 0 None - 1 Human 10.1 pKi = 10.1 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 602 10 2 6 5.2 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCN4CCN(C5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46237033 20970 0 None - 1 Human 10.1 pKi = 10.1 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 359 7 1 4 1.9 N[C@@H](CCC(=O)N1CCN(CC2CCOCC2)CC1)Cc1ccccc1 10.1021/jm100176s
CHEMBL1083974 20970 0 None - 1 Human 10.1 pKi = 10.1 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 359 7 1 4 1.9 N[C@@H](CCC(=O)N1CCN(CC2CCOCC2)CC1)Cc1ccccc1 10.1021/jm100176s
CHEMBL1198853 20970 0 None - 1 Human 10.1 pKi = 10.1 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 359 7 1 4 1.9 N[C@@H](CCC(=O)N1CCN(CC2CCOCC2)CC1)Cc1ccccc1 10.1021/jm100176s
23627061 157960 0 None - 1 Human 10.0 pKi = 10.0 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 701 14 3 7 5.8 CCN(CC)c1ccc2cc(C(=O)NC3(C(=O)N[C@H](Cc4ccccc4)C(=O)NCC4CCN(CC5CCOCC5)CC4)CCCC3)sc2c1 10.1021/jm070289w
CHEMBL395974 157960 0 None - 1 Human 10.0 pKi = 10.0 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 701 14 3 7 5.8 CCN(CC)c1ccc2cc(C(=O)NC3(C(=O)N[C@H](Cc4ccccc4)C(=O)NCC4CCN(CC5CCOCC5)CC4)CCCC3)sc2c1 10.1021/jm070289w
2115 8628 19 None 8 3 Rat 10.0 pKi = 10 Binding
Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon
ChEMBL 414 7 1 3 4.1 COC1(CCN(CC1)CCc1c[nH]c2c1cc(F)cc2)C[S@@](=O)c1ccccc1 10.1016/S0960-894X(01)80541-2
9953599 8628 19 None 8 3 Rat 10.0 pKi = 10 Binding
Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon
ChEMBL 414 7 1 3 4.1 COC1(CCN(CC1)CCc1c[nH]c2c1cc(F)cc2)C[S@@](=O)c1ccccc1 10.1016/S0960-894X(01)80541-2
CHEMBL2110370 8628 19 None 8 3 Rat 10.0 pKi = 10 Binding
Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon
ChEMBL 414 7 1 3 4.1 COC1(CCN(CC1)CCc1c[nH]c2c1cc(F)cc2)C[S@@](=O)c1ccccc1 10.1016/S0960-894X(01)80541-2
10508281 91558 0 None - 1 Human 10.0 pKi = 10 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 633 6 5 4 3.9 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(Cl)c(Cl)c2)CN1 10.1021/jm0010217
CHEMBL223221 91558 0 None - 1 Human 10.0 pKi = 10 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 633 6 5 4 3.9 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(Cl)c(Cl)c2)CN1 10.1021/jm0010217
10508281 91558 0 None - 1 Human 10.0 pKi = 10 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 633 6 5 4 3.9 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(Cl)c(Cl)c2)CN1 10.1021/jm040832y
CHEMBL223221 91558 0 None - 1 Human 10.0 pKi = 10 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 633 6 5 4 3.9 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(Cl)c(Cl)c2)CN1 10.1021/jm040832y
11239751 91946 0 None 1995 3 Human 10.0 pKi = 10 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 785 10 7 8 -0.5 NS(=O)(=O)N1CCN(CC(=O)N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
CHEMBL225297 91946 0 None 1995 3 Human 10.0 pKi = 10 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 785 10 7 8 -0.5 NS(=O)(=O)N1CCN(CC(=O)N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
11193639 149834 0 None - 1 Human 10.0 pKi = 10 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 680 8 6 6 3.0 O=C1C[C@@H](NC2CCSCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL389510 149834 0 None - 1 Human 10.0 pKi = 10 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 680 8 6 6 3.0 O=C1C[C@@H](NC2CCSCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
11445137 13572 0 None - 1 Human 10.0 pKi = 10 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 644 11 2 6 5.3 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(C(=O)C5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083879 13572 0 None - 1 Human 10.0 pKi = 10 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 644 11 2 6 5.3 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(C(=O)C5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
10508281 91558 0 None - 1 Human 10.0 pKi = 10 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 633 6 5 4 3.9 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(Cl)c(Cl)c2)CN1 10.1021/jm011127h
CHEMBL223221 91558 0 None - 1 Human 10.0 pKi = 10 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 633 6 5 4 3.9 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(Cl)c(Cl)c2)CN1 10.1021/jm011127h
10122346 99008 0 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 652 11 3 7 3.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N2CCN(c3ccccn3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
CHEMBL242626 99008 0 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 652 11 3 7 3.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N2CCN(c3ccccn3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
71452717 85673 0 None 5 2 Human 9.9 pKi = 9.9 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 678 7 5 6 1.6 O=C1CC(C(=O)N2CCOCC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
CHEMBL2112925 85673 0 None 5 2 Human 9.9 pKi = 9.9 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 678 7 5 6 1.6 O=C1CC(C(=O)N2CCOCC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
11388737 91803 0 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 691 7 5 6 1.7 CC(=O)N1CCN([C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
CHEMBL224003 91803 0 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 691 7 5 6 1.7 CC(=O)N1CCN([C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
11764349 91841 0 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 721 9 7 7 1.1 O=C1C[C@@H](NC(=O)CN2CCC(O)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL224374 91841 0 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 721 9 7 7 1.1 O=C1C[C@@H](NC(=O)CN2CCC(O)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
46236920 13556 0 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 629 12 2 5 7.3 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCC4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083863 13556 0 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 629 12 2 5 7.3 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCC4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46237170 13562 0 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 640 12 2 5 6.7 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5ccc(F)cc5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083869 13562 0 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 640 12 2 5 6.7 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5ccc(F)cc5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
23626110 156485 0 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 640 12 4 7 2.0 NS(=O)(=O)N1CCN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCCC2)CC1 10.1021/jm070289w
CHEMBL394780 156485 0 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 640 12 4 7 2.0 NS(=O)(=O)N1CCN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCCC2)CC1 10.1021/jm070289w
23627060 157957 0 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 660 12 3 7 4.9 COc1ccc2cc(C(=O)NC3(C(=O)N[C@H](Cc4ccccc4)C(=O)NCC4CCN(CC5CCOCC5)CC4)CCCC3)sc2c1 10.1021/jm070289w
CHEMBL395973 157957 0 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 660 12 3 7 4.9 COc1ccc2cc(C(=O)NC3(C(=O)N[C@H](Cc4ccccc4)C(=O)NCC4CCN(CC5CCOCC5)CC4)CCCC3)sc2c1 10.1021/jm070289w
44302816 207144 0 None - 1 Human 9.8 pKi = 9.8 Binding
Binding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligandBinding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligand
ChEMBL 903 20 7 8 2.4 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)c1ccccc1)C(N)=O 10.1021/jm00039a012
CHEMBL59780 207144 0 None - 1 Human 9.8 pKi = 9.8 Binding
Binding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligandBinding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligand
ChEMBL 903 20 7 8 2.4 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)c1ccccc1)C(N)=O 10.1021/jm00039a012
5487475 96168 29 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
ChEMBL 903 20 7 8 2.4 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)c1ccccc1)C(N)=O 10.1021/jm401823z
CHEMBL2370064 96168 29 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
ChEMBL 903 20 7 8 2.4 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)c1ccccc1)C(N)=O 10.1021/jm401823z
9853827 91996 0 None 794 3 Human 9.8 pKi = 9.8 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 790 10 6 8 1.5 O=C1C[C@@H](NC(=O)CN2CCC(N3CCOCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL225588 91996 0 None 794 3 Human 9.8 pKi = 9.8 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 790 10 6 8 1.5 O=C1C[C@@H](NC(=O)CN2CCC(N3CCOCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
11216552 103737 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 678 8 5 6 2.7 CN(C1CCOCC1)[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1021/jm040832y
CHEMBL266284 103737 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 678 8 5 6 2.7 CN(C1CCOCC1)[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1021/jm040832y
10326920 149777 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 650 7 5 6 1.9 O=C1C[C@@H](N2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL389459 149777 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 650 7 5 6 1.9 O=C1C[C@@H](N2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
11411829 149835 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 712 8 6 7 1.7 O=C1C[C@@H](NC2CCS(=O)(=O)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL389511 149835 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 712 8 6 7 1.7 O=C1C[C@@H](NC2CCS(=O)(=O)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
11228042 168515 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 648 6 6 5 2.8 N[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(Cl)c(Cl)c2)CNC1=O 10.1021/jm040832y
CHEMBL413715 168515 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 648 6 6 5 2.8 N[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(Cl)c(Cl)c2)CNC1=O 10.1021/jm040832y
46237171 13563 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 623 12 2 6 6.0 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5ccccn5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083870 13563 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 623 12 2 6 6.0 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5ccccn5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46237301 13566 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 628 12 2 6 6.6 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5cccs5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083873 13566 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 628 12 2 6 6.6 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5cccs5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46237302 13567 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 628 12 2 6 6.6 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5ccsc5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083874 13567 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 628 12 2 6 6.6 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5ccsc5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46237445 13568 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 612 12 2 6 6.2 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5ccoc5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083875 13568 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 612 12 2 6 6.2 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5ccoc5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
10326920 149777 0 None - 1 Human 9.8 pKi = 9.8 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 650 7 5 6 1.9 O=C1C[C@@H](N2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm011127h
CHEMBL389459 149777 0 None - 1 Human 9.8 pKi = 9.8 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 650 7 5 6 1.9 O=C1C[C@@H](N2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm011127h
11205343 91805 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 731 8 5 6 3.5 O=C1C[C@@H](N2CCC(N3CCCCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL224009 91805 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 731 8 5 6 3.5 O=C1C[C@@H](N2CCC(N3CCCCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
11285709 91961 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 648 6 6 5 2.8 N[C@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(Cl)c(Cl)c2)CNC1=O 10.1021/jm040832y
CHEMBL225392 91961 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 648 6 6 5 2.8 N[C@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(Cl)c(Cl)c2)CNC1=O 10.1021/jm040832y
44421490 149119 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 677 8 6 6 2.2 CN1CCC(N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
CHEMBL388626 149119 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 677 8 6 6 2.2 CN1CCC(N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
11228450 149564 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 733 8 5 7 2.3 O=C1C[C@@H](N2CCC(N3CCOCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL389279 149564 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 733 8 5 7 2.3 O=C1C[C@@H](N2CCC(N3CCOCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
9831546 211954 0 None 1 3 Human 9.7 pKi = 9.7 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 698 12 1 6 5.6 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL78284 211954 0 None 1 3 Human 9.7 pKi = 9.7 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 698 12 1 6 5.6 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44307820 210414 0 None 1 2 Guinea pig 9.7 pKi = 9.7 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL67171 210414 0 None 1 2 Guinea pig 9.7 pKi = 9.7 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
23626743 99349 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 630 11 3 6 4.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
CHEMBL243496 99349 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 630 11 3 6 4.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
53318867 65257 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins
ChEMBL 639 12 3 6 4.5 O=C(NC1(C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1ccc(-n2cccc2)cc1 10.1016/j.bmcl.2011.01.074
CHEMBL1683146 65257 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins
ChEMBL 639 12 3 6 4.5 O=C(NC1(C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1ccc(-n2cccc2)cc1 10.1016/j.bmcl.2011.01.074
23627058 157953 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 648 11 3 6 5.1 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccc(F)cc2s1 10.1021/jm070289w
CHEMBL395971 157953 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 648 11 3 6 5.1 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccc(F)cc2s1 10.1021/jm070289w
11205157 91851 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 718 7 5 6 3.2 O=C1C[C@@H](N2CCOCC2)C(=O)NC[C@@H](Cc2ccc(Cl)c(Cl)c2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL224494 91851 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 718 7 5 6 3.2 O=C1C[C@@H](N2CCOCC2)C(=O)NC[C@@H](Cc2ccc(Cl)c(Cl)c2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
11491634 178324 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 822 10 6 8 1.2 O=C1C[C@@H](NC(=O)CN2CCC(N3CC[S+]([O-])CC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL446450 178324 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 822 10 6 8 1.2 O=C1C[C@@H](NC(=O)CN2CCC(N3CC[S+]([O-])CC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
46238093 13539 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 634 12 2 6 5.7 O=C(NC1(C(=O)N[C@@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1)c1cc2cc(Cl)ccc2o1 10.1021/jm100176s
CHEMBL1083846 13539 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 634 12 2 6 5.7 O=C(NC1(C(=O)N[C@@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1)c1cc2cc(Cl)ccc2o1 10.1021/jm100176s
46236387 13542 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 616 12 2 6 5.5 O=C(NC1(C(=O)N[C@@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1)c1cc2ccccc2s1 10.1021/jm100176s
CHEMBL1083849 13542 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 616 12 2 6 5.5 O=C(NC1(C(=O)N[C@@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1)c1cc2ccccc2s1 10.1021/jm100176s
46237038 13559 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 616 11 2 6 5.6 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(C5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083866 13559 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 616 11 2 6 5.6 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(C5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46237300 13565 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 623 12 2 6 6.0 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5ccncc5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083872 13565 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 623 12 2 6 6.0 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5ccncc5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
10232332 99975 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 596 11 3 6 4.2 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2ccc(Cl)cc2s1 10.1021/jm070289w
CHEMBL244566 99975 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 596 11 3 6 4.2 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2ccc(Cl)cc2s1 10.1021/jm070289w
44307819 109373 0 None -1 2 Guinea pig 9.5 pKi = 9.5 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL304106 109373 0 None -1 2 Guinea pig 9.5 pKi = 9.5 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44307677 176043 0 None 1 2 Guinea pig 9.5 pKi = 9.5 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL441252 176043 0 None 1 2 Guinea pig 9.5 pKi = 9.5 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44307757 210315 0 None -1 2 Guinea pig 9.5 pKi = 9.5 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL66441 210315 0 None -1 2 Guinea pig 9.5 pKi = 9.5 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44307758 210335 0 None -1 2 Guinea pig 9.5 pKi = 9.5 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL66635 210335 0 None -1 2 Guinea pig 9.5 pKi = 9.5 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44383850 66712 0 None - 1 Rat 9.5 pKi = 9.5 Binding
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 552 9 0 4 6.8 CC(=O)OC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/S0960-894X(00)80694-0
CHEMBL173203 66712 0 None - 1 Rat 9.5 pKi = 9.5 Binding
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 552 9 0 4 6.8 CC(=O)OC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/S0960-894X(00)80694-0
44385292 138166 0 None - 1 Rat 9.5 pKi = 9.5 Binding
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 572 10 0 5 7.2 CCN(CC(CCN1CCC(OC(C)=O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cccs1 10.1016/S0960-894X(00)80694-0
CHEMBL368995 138166 0 None - 1 Rat 9.5 pKi = 9.5 Binding
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 572 10 0 5 7.2 CCN(CC(CCN1CCC(OC(C)=O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cccs1 10.1016/S0960-894X(00)80694-0
2115 8628 19 None -8 3 Human 9.5 pKi = 9.5 Binding
Binding affinity against Tachykinin receptor 2 of human expressed in chinese hamster ovary cellsBinding affinity against Tachykinin receptor 2 of human expressed in chinese hamster ovary cells
ChEMBL 414 7 1 3 4.1 COC1(CCN(CC1)CCc1c[nH]c2c1cc(F)cc2)C[S@@](=O)c1ccccc1 10.1016/S0960-894X(01)80541-2
9953599 8628 19 None -8 3 Human 9.5 pKi = 9.5 Binding
Binding affinity against Tachykinin receptor 2 of human expressed in chinese hamster ovary cellsBinding affinity against Tachykinin receptor 2 of human expressed in chinese hamster ovary cells
ChEMBL 414 7 1 3 4.1 COC1(CCN(CC1)CCc1c[nH]c2c1cc(F)cc2)C[S@@](=O)c1ccccc1 10.1016/S0960-894X(01)80541-2
CHEMBL2110370 8628 19 None -8 3 Human 9.5 pKi = 9.5 Binding
Binding affinity against Tachykinin receptor 2 of human expressed in chinese hamster ovary cellsBinding affinity against Tachykinin receptor 2 of human expressed in chinese hamster ovary cells
ChEMBL 414 7 1 3 4.1 COC1(CCN(CC1)CCc1c[nH]c2c1cc(F)cc2)C[S@@](=O)c1ccccc1 10.1016/S0960-894X(01)80541-2
44301859 206591 0 None 35481 2 Rat 9.5 pKi = 9.5 Binding
Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon
ChEMBL 400 6 2 3 3.5 [O-][S@+](CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1)c1ccccc1 10.1016/S0960-894X(01)80541-2
CHEMBL59413 206591 0 None 35481 2 Rat 9.5 pKi = 9.5 Binding
Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon
ChEMBL 400 6 2 3 3.5 [O-][S@+](CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1)c1ccccc1 10.1016/S0960-894X(01)80541-2
44577911 179032 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 664 12 3 5 5.7 Cc1ccc(-c2ccc(C(=O)NC3(C(=O)N[C@H](Cc4ccccc4)C(=O)NCC4CCN(CC5CCOCC5)CC4)CCCC3)cc2)cc1 10.1016/j.bmcl.2008.06.102
CHEMBL447439 179032 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 664 12 3 5 5.7 Cc1ccc(-c2ccc(C(=O)NC3(C(=O)N[C@H](Cc4ccccc4)C(=O)NCC4CCN(CC5CCOCC5)CC4)CCCC3)cc2)cc1 10.1016/j.bmcl.2008.06.102
25071640 181178 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 634 12 3 5 4.8 O=C(/C=C/c1cccc(Cl)c1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1 10.1016/j.bmcl.2008.06.102
CHEMBL455238 181178 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 634 12 3 5 4.8 O=C(/C=C/c1cccc(Cl)c1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1 10.1016/j.bmcl.2008.06.102
71449111 85670 0 None 6 2 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 759 8 5 6 3.3 O=C1CC(C(=O)N2CCC(N3CCCCC3)CC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
CHEMBL2112922 85670 0 None 6 2 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 759 8 5 6 3.3 O=C1CC(C(=O)N2CCC(N3CCCCC3)CC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
11193706 17287 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 707 9 6 7 1.0 O=C1C[C@@H](NC(=O)CN2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL116812 17287 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 707 9 6 7 1.0 O=C1C[C@@H](NC(=O)CN2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
11251435 91846 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 721 10 7 7 1.1 O=C1C[C@@H](NC(=O)CN2CCC[C@H]2CO)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL224426 91846 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 721 10 7 7 1.1 O=C1C[C@@H](NC(=O)CN2CCC[C@H]2CO)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
11400251 150638 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 739 9 6 7 0.7 O=C1C[C@@H](NC(=O)CN2CC[S+]([O-])CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL390168 150638 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 739 9 6 7 0.7 O=C1C[C@@H](NC(=O)CN2CC[S+]([O-])CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
46237960 13465 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 610 12 2 5 5.4 O=C(NC1(C(=O)N[C@@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1)c1ccc2ccccc2c1 10.1021/jm100176s
CHEMBL1083561 13465 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 610 12 2 5 5.4 O=C(NC1(C(=O)N[C@@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1)c1ccc2ccccc2c1 10.1021/jm100176s
46889640 13548 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 630 11 2 6 5.9 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCN4CCC(N(C)C5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083855 13548 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 630 11 2 6 5.9 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCN4CCC(N(C)C5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46237299 13564 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 623 12 2 6 6.0 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5cccnc5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083871 13564 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 623 12 2 6 6.0 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5cccnc5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46236394 13570 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 628 12 2 9 4.1 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5nnn(C)n5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083877 13570 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 628 12 2 9 4.1 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5nnn(C)n5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46236396 13571 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 618 15 2 6 5.8 CCOCCCN1CCN(CCC[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccc(C)cc4s3)CCCC2)CC1 10.1021/jm100176s
CHEMBL1083878 13571 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 618 15 2 6 5.8 CCOCCCN1CCN(CCC[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccc(C)cc4s3)CCCC2)CC1 10.1021/jm100176s
46236516 13640 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 639 12 2 6 4.2 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(S(=O)(=O)N(C)C)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1084160 13640 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 639 12 2 6 4.2 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(S(=O)(=O)N(C)C)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
44577911 179032 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 664 12 3 5 5.7 Cc1ccc(-c2ccc(C(=O)NC3(C(=O)N[C@H](Cc4ccccc4)C(=O)NCC4CCN(CC5CCOCC5)CC4)CCCC3)cc2)cc1 10.1021/jm100176s
CHEMBL447439 179032 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 664 12 3 5 5.7 Cc1ccc(-c2ccc(C(=O)NC3(C(=O)N[C@H](Cc4ccccc4)C(=O)NCC4CCN(CC5CCOCC5)CC4)CCCC3)cc2)cc1 10.1021/jm100176s
11193706 17287 0 None - 1 Human 9.5 pKi = 9.5 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 707 9 6 7 1.0 O=C1C[C@@H](NC(=O)CN2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm011127h
CHEMBL116812 17287 0 None - 1 Human 9.5 pKi = 9.5 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 707 9 6 7 1.0 O=C1C[C@@H](NC(=O)CN2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm011127h
53324157 65262 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins
ChEMBL 610 12 2 5 5.4 O=C(NC1(C(=O)N[C@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1)c1ccc2ccccc2c1 10.1016/j.bmcl.2011.01.074
CHEMBL1683151 65262 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins
ChEMBL 610 12 2 5 5.4 O=C(NC1(C(=O)N[C@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1)c1ccc2ccccc2c1 10.1016/j.bmcl.2011.01.074
9961315 124702 0 None -2 3 Human 9.5 pKi = 9.5 Binding
Inhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) in mouse erythroleukemia cellsInhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) in mouse erythroleukemia cells
ChEMBL 661 10 0 5 7.9 COc1ccc(C2CCN(CC[C@H](CN(C)C(=O)c3cc(C#N)cc4ccccc34)c3ccc(Cl)c(Cl)c3)CC2)c([S@+](C)[O-])c1 10.1021/jm020094i
CHEMBL340326 124702 0 None -2 3 Human 9.5 pKi = 9.5 Binding
Inhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) in mouse erythroleukemia cellsInhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) in mouse erythroleukemia cells
ChEMBL 661 10 0 5 7.9 COc1ccc(C2CCN(CC[C@H](CN(C)C(=O)c3cc(C#N)cc4ccccc34)c3ccc(Cl)c(Cl)c3)CC2)c([S@+](C)[O-])c1 10.1021/jm020094i
23626900 157962 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 596 11 3 6 4.2 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2cccc(Cl)c2s1 10.1021/jm070289w
CHEMBL395975 157962 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 596 11 3 6 4.2 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2cccc(Cl)c2s1 10.1021/jm070289w
44434191 156615 0 None 501 2 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 588 11 3 5 5.4 CC1CCCCN1CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
CHEMBL394889 156615 0 None 501 2 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 588 11 3 5 5.4 CC1CCCCN1CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
11274473 91800 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 744 13 11 10 -1.4 O=C1C[C@@H](NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL223993 91800 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 744 13 11 10 -1.4 O=C1C[C@@H](NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
10876489 91979 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 788 10 6 7 2.6 O=C1C[C@@H](NC(=O)CN2CCC(N3CCCCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL225475 91979 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 788 10 6 7 2.6 O=C1C[C@@H](NC(=O)CN2CCC(N3CCCCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
11331994 175801 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 663 7 5 6 1.8 CN1CCN([C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
CHEMBL439377 175801 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 663 7 5 6 1.8 CN1CCN([C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
46238232 13541 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 614 12 2 6 5.3 Cc1ccc2oc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)cc2c1 10.1021/jm100176s
CHEMBL1083848 13541 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 614 12 2 6 5.3 Cc1ccc2oc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)cc2c1 10.1021/jm100176s
46236510 13573 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 639 11 2 6 5.6 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(C(=O)c5cccn5C)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083880 13573 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 639 11 2 6 5.6 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(C(=O)c5cccn5C)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46236512 13638 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 645 10 2 6 4.8 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(C(=O)N5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1084158 13638 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 645 10 2 6 4.8 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(C(=O)N5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
44343142 162638 0 None - 1 Human 9.4 pKi = 9.4 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 788 10 6 7 2.6 O=C1C[C@@H](NC(=O)CN2CCC(N3CCCCC3)CC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm011127h
CHEMBL406024 162638 0 None - 1 Human 9.4 pKi = 9.4 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 788 10 6 7 2.6 O=C1C[C@@H](NC(=O)CN2CCC(N3CCCCC3)CC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm011127h
2106 10319 4 None -1 3 Human 9.4 pKi = 9.4 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 711 12 1 6 6.4 CO/N=C(/[C@@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)N1CCC[C@@H](C1=O)CC(=O)NC)\CN(C(=O)c1cc(Cl)cc(c1)Cl)C 10.1016/s0960-894x(02)00462-6
9875034 10319 4 None -1 3 Human 9.4 pKi = 9.4 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 711 12 1 6 6.4 CO/N=C(/[C@@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)N1CCC[C@@H](C1=O)CC(=O)NC)\CN(C(=O)c1cc(Cl)cc(c1)Cl)C 10.1016/s0960-894x(02)00462-6
CHEMBL77023 10319 4 None -1 3 Human 9.4 pKi = 9.4 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 711 12 1 6 6.4 CO/N=C(/[C@@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)N1CCC[C@@H](C1=O)CC(=O)NC)\CN(C(=O)c1cc(Cl)cc(c1)Cl)C 10.1016/s0960-894x(02)00462-6
9810544 211571 0 None -1 3 Human 9.4 pKi = 9.4 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 726 12 1 6 6.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(C(C)(C)C(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL74956 211571 0 None -1 3 Human 9.4 pKi = 9.4 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 726 12 1 6 6.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(C(C)(C)C(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
155551678 182211 0 None -1 3 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]NKA from human NK2 receptor expressed in CHO cells membranesDisplacement of [3H]NKA from human NK2 receptor expressed in CHO cells membranes
ChEMBL 697 12 1 6 6.9 CNC(=O)C[C@H]1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1 10.1021/acs.jmedchem.9b00017
CHEMBL4576324 182211 0 None -1 3 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]NKA from human NK2 receptor expressed in CHO cells membranesDisplacement of [3H]NKA from human NK2 receptor expressed in CHO cells membranes
ChEMBL 697 12 1 6 6.9 CNC(=O)C[C@H]1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1 10.1021/acs.jmedchem.9b00017
44307898 208252 0 None 1 2 Guinea pig 9.4 pKi = 9.4 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL60504 208252 0 None 1 2 Guinea pig 9.4 pKi = 9.4 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44307679 210296 0 None 1 2 Guinea pig 9.4 pKi = 9.4 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
CHEMBL66332 210296 0 None 1 2 Guinea pig 9.4 pKi = 9.4 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
23625950 149659 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 578 11 3 6 4.2 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCSCC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
CHEMBL389355 149659 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 578 11 3 6 4.2 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCSCC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
104974 10248 31 None -1 7 Bovine 9.3 pKi = 9.3 Binding
Binding affinity against bovine Tachykinin receptor 2Binding affinity against bovine Tachykinin receptor 2
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/j.bmcl.2004.06.053
2111 10248 31 None -1 7 Bovine 9.3 pKi = 9.3 Binding
Binding affinity against bovine Tachykinin receptor 2Binding affinity against bovine Tachykinin receptor 2
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/j.bmcl.2004.06.053
3481 10248 31 None -1 7 Bovine 9.3 pKi = 9.3 Binding
Binding affinity against bovine Tachykinin receptor 2Binding affinity against bovine Tachykinin receptor 2
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/j.bmcl.2004.06.053
CHEMBL308148 10248 31 None -1 7 Bovine 9.3 pKi = 9.3 Binding
Binding affinity against bovine Tachykinin receptor 2Binding affinity against bovine Tachykinin receptor 2
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/j.bmcl.2004.06.053
DB06660 10248 31 None -1 7 Bovine 9.3 pKi = 9.3 Binding
Binding affinity against bovine Tachykinin receptor 2Binding affinity against bovine Tachykinin receptor 2
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/j.bmcl.2004.06.053
44315483 103374 0 None -1 3 Human 9.3 pKi = 9.3 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 728 13 2 7 5.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN([C@H](CO)C(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL263243 103374 0 None -1 3 Human 9.3 pKi = 9.3 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 728 13 2 7 5.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN([C@H](CO)C(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
9831707 211806 0 None 1 3 Human 9.3 pKi = 9.3 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 718 11 0 6 7.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(c3ccccn3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL76965 211806 0 None 1 3 Human 9.3 pKi = 9.3 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 718 11 0 6 7.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(c3ccccn3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
9853636 212229 0 None -1 3 Human 9.3 pKi = 9.3 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 762 14 1 7 5.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CCNS(C)(=O)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL80355 212229 0 None -1 3 Human 9.3 pKi = 9.3 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 762 14 1 7 5.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CCNS(C)(=O)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
102023780 127525 0 None -1 2 Human 9.3 pKi = 9.3 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 698 12 3 7 6.4 CN(C/C(=N\OCC(=N)NO)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
10417302 127525 0 None -1 2 Human 9.3 pKi = 9.3 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 698 12 3 7 6.4 CN(C/C(=N\OCC(=N)NO)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44380072 127525 0 None -1 2 Human 9.3 pKi = 9.3 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 698 12 3 7 6.4 CN(C/C(=N\OCC(=N)NO)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL355041 127525 0 None -1 2 Human 9.3 pKi = 9.3 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 698 12 3 7 6.4 CN(C/C(=N\OCC(=N)NO)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
104974 10248 31 None 1 7 Human 9.3 pKi = 9.3 Binding
Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/s0960-894x(00)00463-7
2111 10248 31 None 1 7 Human 9.3 pKi = 9.3 Binding
Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/s0960-894x(00)00463-7
3481 10248 31 None 1 7 Human 9.3 pKi = 9.3 Binding
Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/s0960-894x(00)00463-7
CHEMBL308148 10248 31 None 1 7 Human 9.3 pKi = 9.3 Binding
Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/s0960-894x(00)00463-7
DB06660 10248 31 None 1 7 Human 9.3 pKi = 9.3 Binding
Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/s0960-894x(00)00463-7
104974 10248 31 None -7 7 Rat 9.3 pKi = 9.3 Binding
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(00)80694-0
2111 10248 31 None -7 7 Rat 9.3 pKi = 9.3 Binding
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(00)80694-0
3481 10248 31 None -7 7 Rat 9.3 pKi = 9.3 Binding
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(00)80694-0
CHEMBL308148 10248 31 None -7 7 Rat 9.3 pKi = 9.3 Binding
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(00)80694-0
DB06660 10248 31 None -7 7 Rat 9.3 pKi = 9.3 Binding
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(00)80694-0
9843958 207572 1 None - 1 Rat 9.3 pKi = 9.3 Binding
Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon
ChEMBL 400 6 2 3 3.5 [O-][S+](CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1)c1ccccc1 10.1016/S0960-894X(01)80541-2
CHEMBL60064 207572 1 None - 1 Rat 9.3 pKi = 9.3 Binding
Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon
ChEMBL 400 6 2 3 3.5 [O-][S+](CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1)c1ccccc1 10.1016/S0960-894X(01)80541-2
44577907 179230 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 614 12 3 5 4.4 Cc1ccc(/C=C/C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
CHEMBL447971 179230 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 614 12 3 5 4.4 Cc1ccc(/C=C/C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
44421494 148786 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 1068 19 17 20 -5.8 O=C1C[C@@H](NC[C@H](O)[C@H](O)[C@@H](O[C@H]2O[C@H](CO)[C@@H](O[C@@H]3O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]3O)[C@H](O)[C@H]2O)[C@H](O)CO)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL387542 148786 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 1068 19 17 20 -5.8 O=C1C[C@@H](NC[C@H](O)[C@H](O)[C@@H](O[C@H]2O[C@H](CO)[C@@H](O[C@@H]3O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]3O)[C@H](O)[C@H]2O)[C@H](O)CO)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
11468591 150636 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 748 10 7 7 0.9 NC(=O)C1CCN(CC(=O)N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
CHEMBL390167 150636 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 748 10 7 7 0.9 NC(=O)C1CCN(CC(=O)N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
46237957 13464 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 636 13 2 5 5.9 O=C(NC1(C(=O)N[C@@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1)c1ccc(-c2ccccc2)cc1 10.1021/jm100176s
CHEMBL1083560 13464 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 636 13 2 5 5.9 O=C(NC1(C(=O)N[C@@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1)c1ccc(-c2ccccc2)cc1 10.1021/jm100176s
46236647 13547 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 616 11 2 6 5.6 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCC(N5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083854 13547 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 616 11 2 6 5.6 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCC(N5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46236798 13554 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 628 11 2 6 5.6 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](/C=C/CN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083861 13554 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 628 11 2 6 5.6 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](/C=C/CN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
11239162 13558 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 645 13 2 6 6.5 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](COCCC4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083865 13558 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 645 13 2 6 6.5 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](COCCC4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46236514 13639 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 681 12 2 7 4.0 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(S(=O)(=O)N5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1084159 13639 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 681 12 2 7 4.0 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(S(=O)(=O)N5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46236655 13642 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 638 12 2 6 5.1 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(S(=O)(=O)C(C)C)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1084162 13642 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 638 12 2 6 5.1 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(S(=O)(=O)C(C)C)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
2110 9743 38 None -1 6 Rat 9.3 pKi = 9.3 Binding
Ability to displace [125I]NKA from Tachykinin receptor 2 in rat deodenum membraneAbility to displace [125I]NKA from Tachykinin receptor 2 in rat deodenum membrane
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm9602423
219077 9743 38 None -1 6 Rat 9.3 pKi = 9.3 Binding
Ability to displace [125I]NKA from Tachykinin receptor 2 in rat deodenum membraneAbility to displace [125I]NKA from Tachykinin receptor 2 in rat deodenum membrane
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm9602423
3480 9743 38 None -1 6 Rat 9.3 pKi = 9.3 Binding
Ability to displace [125I]NKA from Tachykinin receptor 2 in rat deodenum membraneAbility to displace [125I]NKA from Tachykinin receptor 2 in rat deodenum membrane
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm9602423
CHEMBL346178 9743 38 None -1 6 Rat 9.3 pKi = 9.3 Binding
Ability to displace [125I]NKA from Tachykinin receptor 2 in rat deodenum membraneAbility to displace [125I]NKA from Tachykinin receptor 2 in rat deodenum membrane
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm9602423
DB04872 9743 38 None -1 6 Rat 9.3 pKi = 9.3 Binding
Ability to displace [125I]NKA from Tachykinin receptor 2 in rat deodenum membraneAbility to displace [125I]NKA from Tachykinin receptor 2 in rat deodenum membrane
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm9602423
23626744 99352 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 616 10 3 6 4.7 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(C3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
CHEMBL243498 99352 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 616 10 3 6 4.7 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(C3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
2109 10909 4 None -5 3 Human 9.2 pKi = 9.2 Binding
Binding affinity against human cloned Tachykinin receptor 2 expressed in MEL cellsBinding affinity against human cloned Tachykinin receptor 2 expressed in MEL cells
ChEMBL 631 9 0 4 7.9 N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C 10.1016/s0960-894x(01)00572-8
9852253 10909 4 None -5 3 Human 9.2 pKi = 9.2 Binding
Binding affinity against human cloned Tachykinin receptor 2 expressed in MEL cellsBinding affinity against human cloned Tachykinin receptor 2 expressed in MEL cells
ChEMBL 631 9 0 4 7.9 N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C 10.1016/s0960-894x(01)00572-8
CHEMBL129683 10909 4 None -5 3 Human 9.2 pKi = 9.2 Binding
Binding affinity against human cloned Tachykinin receptor 2 expressed in MEL cellsBinding affinity against human cloned Tachykinin receptor 2 expressed in MEL cells
ChEMBL 631 9 0 4 7.9 N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C 10.1016/s0960-894x(01)00572-8
9830361 188405 0 None -1 3 Human 9.2 pKi = 9.2 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 538 7 1 4 7.1 C[C@H](NC(=O)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2ccccc2)nc2ccccc12)C1CCCCC1 10.1021/jm000501v
CHEMBL47739 188405 0 None -1 3 Human 9.2 pKi = 9.2 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 538 7 1 4 7.1 C[C@H](NC(=O)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2ccccc2)nc2ccccc12)C1CCCCC1 10.1021/jm000501v
9850582 204021 22 None -1 6 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
CHEMBL56835 204021 22 None -1 6 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
44307741 210566 0 None -15 2 Guinea pig 9.2 pKi = 9.2 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL68234 210566 0 None -15 2 Guinea pig 9.2 pKi = 9.2 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL334721 218178 1 None 9 3 Human 9.2 pKi = 9.2 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL None None None CSCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CNC(=O)C[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2 10.1021/jm0010217
10281234 99009 0 None 38 2 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 562 11 3 6 3.5 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
CHEMBL242631 99009 0 None 38 2 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 562 11 3 6 3.5 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
71458042 85671 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 692 8 5 6 2.0 O=C1C[C@@H](CC(=O)N2CCOCC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
CHEMBL2112923 85671 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 692 8 5 6 2.0 O=C1C[C@@H](CC(=O)N2CCOCC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
44421493 91801 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 906 16 14 15 -3.6 O=C1C[C@@H](NC[C@H](O)[C@@H](O)[C@@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)CO)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL223994 91801 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 906 16 14 15 -3.6 O=C1C[C@@H](NC[C@H](O)[C@@H](O)[C@@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)CO)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
46237825 13463 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 650 13 2 5 6.3 Cc1ccc(-c2ccc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)cc2)cc1 10.1021/jm100176s
CHEMBL1083559 13463 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 650 13 2 5 6.3 Cc1ccc(-c2ccc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)cc2)cc1 10.1021/jm100176s
46238229 13540 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 630 13 2 7 5.0 COc1ccc2oc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)cc2c1 10.1021/jm100176s
CHEMBL1083847 13540 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 630 13 2 7 5.0 COc1ccc2oc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)cc2c1 10.1021/jm100176s
9874027 13544 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 630 12 2 6 5.8 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@H](CCCN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083851 13544 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 630 12 2 6 5.8 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@H](CCCN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46237037 13557 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 631 12 2 6 6.1 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](COCC4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083864 13557 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 631 12 2 6 6.1 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](COCC4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46237168 13560 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 609 11 2 6 6.0 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(c5ccccn5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083867 13560 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 609 11 2 6 6.0 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(c5ccccn5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46889663 13641 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 611 11 3 6 3.6 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(S(N)(=O)=O)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1084161 13641 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 611 11 3 6 3.6 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(S(N)(=O)=O)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46237698 13643 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 624 12 2 6 4.7 CCS(=O)(=O)N1CCN(CCC[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccc(C)cc4s3)CCCC2)CC1 10.1021/jm100176s
CHEMBL1084163 13643 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 624 12 2 6 4.7 CCS(=O)(=O)N1CCN(CCC[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccc(C)cc4s3)CCCC2)CC1 10.1021/jm100176s
46238091 13782 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 600 12 2 6 5.0 O=C(NC1(C(=O)N[C@@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1)c1cc2ccccc2o1 10.1021/jm100176s
CHEMBL1084765 13782 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 600 12 2 6 5.0 O=C(NC1(C(=O)N[C@@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1)c1cc2ccccc2o1 10.1021/jm100176s
2109 10909 4 None -5 3 Human 9.2 pKi = 9.2 Binding
Inhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cellsInhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cells
ChEMBL 631 9 0 4 7.9 N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C 10.1021/jm020094i
9852253 10909 4 None -5 3 Human 9.2 pKi = 9.2 Binding
Inhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cellsInhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cells
ChEMBL 631 9 0 4 7.9 N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C 10.1021/jm020094i
CHEMBL129683 10909 4 None -5 3 Human 9.2 pKi = 9.2 Binding
Inhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cellsInhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cells
ChEMBL 631 9 0 4 7.9 N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C 10.1021/jm020094i
10281234 99009 0 None 38 2 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 562 11 3 6 3.5 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
CHEMBL242631 99009 0 None 38 2 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 562 11 3 6 3.5 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
9852630 211632 0 None -1 3 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 655 10 0 5 6.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL75598 211632 0 None -1 3 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 655 10 0 5 6.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
9896757 211760 0 None -1 3 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 732 12 0 6 7.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3ccccn3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL76580 211760 0 None -1 3 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 732 12 0 6 7.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3ccccn3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
9831075 211932 0 None 1 3 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 657 10 1 6 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL78132 211932 0 None 1 3 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 657 10 1 6 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44380396 64494 0 None -1 2 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 698 12 3 7 6.4 CN(C/C(=N\OCC(=N)NO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL166921 64494 0 None -1 2 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 698 12 3 7 6.4 CN(C/C(=N\OCC(=N)NO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
9872857 188533 0 None 2 3 Human 9.2 pKi = 9.2 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 498 7 1 4 6.1 CC(C)N1CCN(Cc2c(-c3ccccc3)nc3ccccc3c2C(=O)N[C@@H](C)C2CCCCC2)CC1 10.1021/jm000501v
CHEMBL47775 188533 0 None 2 3 Human 9.2 pKi = 9.2 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 498 7 1 4 6.1 CC(C)N1CCN(Cc2c(-c3ccccc3)nc3ccccc3c2C(=O)N[C@@H](C)C2CCCCC2)CC1 10.1021/jm000501v
44307773 109137 0 None -17 2 Guinea pig 9.2 pKi = 9.2 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 779 13 0 7 7.6 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)C3CCN(C)CC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL303803 109137 0 None -17 2 Guinea pig 9.2 pKi = 9.2 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 779 13 0 7 7.6 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)C3CCN(C)CC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
2089 9542 28 None 102 5 Human 9.2 pKi = 9.2 Binding
The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
3795 9542 28 None 102 5 Human 9.2 pKi = 9.2 Binding
The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
5311311 9542 28 None 102 5 Human 9.2 pKi = 9.2 Binding
The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
CHEMBL217406 9542 28 None 102 5 Human 9.2 pKi = 9.2 Binding
The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
10303894 92778 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 588 12 3 6 4.0 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1ccc(-c2ccccc2)s1 10.1021/jm070289w
CHEMBL230424 92778 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 588 12 3 6 4.0 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1ccc(-c2ccccc2)s1 10.1021/jm070289w
23626412 155932 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 659 11 3 7 3.5 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N2CCC(N3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
CHEMBL394350 155932 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 659 11 3 7 3.5 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N2CCC(N3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
10166998 173460 0 None 125 2 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 576 11 3 6 3.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCCC1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
CHEMBL428203 173460 0 None 125 2 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 576 11 3 6 3.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCCC1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
44577893 176796 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 634 13 3 6 4.8 CCSc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
CHEMBL444253 176796 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 634 13 3 6 4.8 CCSc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
44577903 176824 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 630 13 3 6 4.1 COc1cccc(/C=C/C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)c1 10.1016/j.bmcl.2008.06.102
CHEMBL444289 176824 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 630 13 3 6 4.1 COc1cccc(/C=C/C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)c1 10.1016/j.bmcl.2008.06.102
11285716 148815 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 650 7 5 6 1.9 O=C1C[C@H](N2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL387698 148815 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 650 7 5 6 1.9 O=C1C[C@H](N2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL406287 148815 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 650 7 5 6 1.9 O=C1C[C@H](N2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
46236796 13553 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 644 11 2 6 5.3 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCC(C(=O)N5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083860 13553 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 644 11 2 6 5.3 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCC(C(=O)N5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46237169 13561 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 610 11 2 7 5.4 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(c5ncccn5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083868 13561 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 610 11 2 7 5.4 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(c5ncccn5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46889664 13644 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 672 11 2 6 5.1 CC/N=C(\N1CCOCC1)N1CCN(CCC[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccc(C)cc4s3)CCCC2)CC1 10.1021/jm100176s
CHEMBL1084164 13644 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 672 11 2 6 5.1 CC/N=C(\N1CCOCC1)N1CCN(CCC[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccc(C)cc4s3)CCCC2)CC1 10.1021/jm100176s
11285716 148815 0 None - 1 Human 9.1 pKi = 9.1 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 650 7 5 6 1.9 O=C1C[C@H](N2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm011127h
CHEMBL387698 148815 0 None - 1 Human 9.1 pKi = 9.1 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 650 7 5 6 1.9 O=C1C[C@H](N2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm011127h
CHEMBL406287 148815 0 None - 1 Human 9.1 pKi = 9.1 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 650 7 5 6 1.9 O=C1C[C@H](N2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm011127h
9810434 111160 0 None -1 3 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 713 12 1 6 6.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(C)(C)O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL310273 111160 0 None -1 3 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 713 12 1 6 6.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(C)(C)O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
101195489 162399 0 None -1 3 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 713 12 3 7 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(=N)NO)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
9875056 162399 0 None -1 3 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 713 12 3 7 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(=N)NO)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL404599 162399 0 None -1 3 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 713 12 3 7 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(=N)NO)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
9917970 211732 0 None -1 3 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 683 11 0 5 7.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(C(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL76437 211732 0 None -1 3 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 683 11 0 5 7.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(C(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44380206 64546 0 None -1 2 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 658 11 0 5 7.3 CN(C/C(=N\OCF)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL166961 64546 0 None -1 2 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 658 11 0 5 7.3 CN(C/C(=N\OCF)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44380448 127058 0 None -1 2 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 670 12 1 6 6.4 CN(C/C(=N\OCCO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL352588 127058 0 None -1 2 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 670 12 1 6 6.4 CN(C/C(=N\OCCO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
10370066 179557 1 None 1 2 Human 9.1 pKi = 9.1 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 540 7 1 5 5.9 C[C@H](NC(=O)c1c(CN2CCC(N3CCOCC3)CC2)c(-c2ccccc2)nc2ccccc12)C1CCCCC1 10.1021/jm000501v
CHEMBL45129 179557 1 None 1 2 Human 9.1 pKi = 9.1 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 540 7 1 5 5.9 C[C@H](NC(=O)c1c(CN2CCC(N3CCOCC3)CC2)c(-c2ccccc2)nc2ccccc12)C1CCCCC1 10.1021/jm000501v
44307821 108891 0 None -4 2 Guinea pig 9.1 pKi = 9.1 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL302329 108891 0 None -4 2 Guinea pig 9.1 pKi = 9.1 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
9874206 210550 0 None -1 2 Guinea pig 9.1 pKi = 9.1 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL68060 210550 0 None -1 2 Guinea pig 9.1 pKi = 9.1 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
23626108 85903 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 589 11 4 6 3.9 C[C@H]1CN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCCC2)C[C@@H](C)N1 10.1021/jm070289w
CHEMBL2113292 85903 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 589 11 4 6 3.9 C[C@H]1CN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCCC2)C[C@@H](C)N1 10.1021/jm070289w
54537190 86418 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 504 10 1 3 6.5 CCC(O)(CC)C1CCN(CC[C@H](CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
CHEMBL2115073 86418 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 504 10 1 3 6.5 CCC(O)(CC)C1CCN(CC[C@H](CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
23625325 150126 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 630 11 3 6 5.1 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC2CCN(C3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
CHEMBL389744 150126 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 630 11 3 6 5.1 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC2CCN(C3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
23626568 99005 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 673 12 3 7 3.7 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
CHEMBL242619 99005 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 673 12 3 7 3.7 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
9961936 109866 0 None 1 3 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 723 12 1 8 5.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3nn[nH]n3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL307498 109866 0 None 1 3 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 723 12 1 8 5.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3nn[nH]n3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
9961955 179552 0 None -1 3 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 726 11 0 7 6.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL451235 179552 0 None -1 3 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 726 11 0 7 6.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44337354 12229 0 None 58 2 Human 9.1 pKi = 9.1 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 656 8 2 7 5.3 CC(=O)Nc1nc(CN2CCC(NCC(=O)N3CCN(C(=O)c4cc(C)cc(C)c4)C[C@H]3c3ccc(Cl)c(Cl)c3)CC2)cs1 10.1016/s0960-894x(02)00645-5
CHEMBL107469 12229 0 None 58 2 Human 9.1 pKi = 9.1 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 656 8 2 7 5.3 CC(=O)Nc1nc(CN2CCC(NCC(=O)N3CCN(C(=O)c4cc(C)cc(C)c4)C[C@H]3c3ccc(Cl)c(Cl)c3)CC2)cs1 10.1016/s0960-894x(02)00645-5
44307678 205454 0 None -1 2 Guinea pig 9.1 pKi = 9.1 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
CHEMBL57993 205454 0 None -1 2 Guinea pig 9.1 pKi = 9.1 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
44384522 66851 0 None - 1 Rat 9.1 pKi = 9.1 Binding
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 538 10 0 3 7.3 CCOC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/S0960-894X(00)80694-0
CHEMBL173841 66851 0 None - 1 Rat 9.1 pKi = 9.1 Binding
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 538 10 0 3 7.3 CCOC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/S0960-894X(00)80694-0
44351946 124147 1 None 1778 3 Human 9.0 pKi = 9.0 Binding
Inhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cellsInhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cells
ChEMBL 568 8 0 3 7.3 CCN1C(=O)c2ccccc2[C@H]1[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm020094i
CHEMBL339767 124147 1 None 1778 3 Human 9.0 pKi = 9.0 Binding
Inhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cellsInhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cells
ChEMBL 568 8 0 3 7.3 CCN1C(=O)c2ccccc2[C@H]1[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm020094i
18964186 211083 0 None -3 3 Bovine 9.0 pKi = 9 Binding
Binding affinity against bovine Tachykinin receptor 2Binding affinity against bovine Tachykinin receptor 2
ChEMBL 510 8 1 3 6.2 CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/j.bmcl.2004.06.053
CHEMBL71397 211083 0 None -3 3 Bovine 9.0 pKi = 9 Binding
Binding affinity against bovine Tachykinin receptor 2Binding affinity against bovine Tachykinin receptor 2
ChEMBL 510 8 1 3 6.2 CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/j.bmcl.2004.06.053
153996 119445 2 None -3 3 Human 9.0 pKi = 9 Binding
Binding affinity against human cloned Tachykinin receptor 2 expressed in MEL cellsBinding affinity against human cloned Tachykinin receptor 2 expressed in MEL cells
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(01)00572-8
CHEMBL330366 119445 2 None -3 3 Human 9.0 pKi = 9 Binding
Binding affinity against human cloned Tachykinin receptor 2 expressed in MEL cellsBinding affinity against human cloned Tachykinin receptor 2 expressed in MEL cells
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(01)00572-8
CHEMBL539021 119445 2 None -3 3 Human 9.0 pKi = 9 Binding
Binding affinity against human cloned Tachykinin receptor 2 expressed in MEL cellsBinding affinity against human cloned Tachykinin receptor 2 expressed in MEL cells
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(01)00572-8
15508105 211610 0 None 1 3 Human 9.0 pKi = 9 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 675 10 1 7 7.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL75422 211610 0 None 1 3 Human 9.0 pKi = 9 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 675 10 1 7 7.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
10432325 24727 0 None - 1 Rat 9.0 pKi = 9 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 421 5 1 3 4.6 Cc1ccc(CN2CC3(CCN(CCc4c[nH]c5ccc(F)cc45)CC3)OC2=O)cc1 10.1021/jm00019a006
CHEMBL126050 24727 0 None - 1 Rat 9.0 pKi = 9 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 421 5 1 3 4.6 Cc1ccc(CN2CC3(CCN(CCc4c[nH]c5ccc(F)cc45)CC3)OC2=O)cc1 10.1021/jm00019a006
44281649 115797 0 None 1 2 Human 9.0 pKi = 9 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 625 11 1 7 6.0 CO/N=C(\CN(C)C(=O)c1cc(C)nc(N(C)C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32124 115797 0 None 1 2 Human 9.0 pKi = 9 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 625 11 1 7 6.0 CO/N=C(\CN(C)C(=O)c1cc(C)nc(N(C)C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281332 119687 0 None 100 2 Human 9.0 pKi = 9 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 588 11 1 8 6.4 CO/N=C(\COCc1noc(C(C)(C)C)n1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33106 119687 0 None 100 2 Human 9.0 pKi = 9 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 588 11 1 8 6.4 CO/N=C(\COCc1noc(C(C)(C)C)n1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
5769 10297 5 None 194 2 Human 9.0 pKi = 9 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 512 6 1 4 6.5 O=C(c1c(CN2CCC(CC2)N2CCCCC2)c(nc2c1cccc2)c1ccccc1)N[C@H](C(C)(C)C)C 10.1021/jm000501v
9806459 10297 5 None 194 2 Human 9.0 pKi = 9 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 512 6 1 4 6.5 O=C(c1c(CN2CCC(CC2)N2CCCCC2)c(nc2c1cccc2)c1ccccc1)N[C@H](C(C)(C)C)C 10.1021/jm000501v
CHEMBL295770 10297 5 None 194 2 Human 9.0 pKi = 9 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 512 6 1 4 6.5 O=C(c1c(CN2CCC(CC2)N2CCCCC2)c(nc2c1cccc2)c1ccccc1)N[C@H](C(C)(C)C)C 10.1021/jm000501v
44434198 156602 0 None 25 2 Human 9.0 pKi = 9 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 623 11 3 6 4.0 CN1CCN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCc3ccccc32)CC1 10.1016/j.bmcl.2007.06.053
CHEMBL394878 156602 0 None 25 2 Human 9.0 pKi = 9 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 623 11 3 6 4.0 CN1CCN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCc3ccccc32)CC1 10.1016/j.bmcl.2007.06.053
44577908 177856 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 646 13 3 6 4.8 CSc1ccc(/C=C/C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
CHEMBL445730 177856 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 646 13 3 6 4.8 CSc1ccc(/C=C/C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
44577898 178081 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 618 12 3 5 4.3 O=C(/C=C/c1cccc(F)c1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1 10.1016/j.bmcl.2008.06.102
CHEMBL446086 178081 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 618 12 3 5 4.3 O=C(/C=C/c1cccc(F)c1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1 10.1016/j.bmcl.2008.06.102
44577906 179581 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 614 12 3 5 4.4 Cc1cccc(/C=C/C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)c1 10.1016/j.bmcl.2008.06.102
CHEMBL451374 179581 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 614 12 3 5 4.4 Cc1cccc(/C=C/C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)c1 10.1016/j.bmcl.2008.06.102
44577900 195664 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 634 12 3 5 4.8 O=C(/C=C/c1ccccc1Cl)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1 10.1016/j.bmcl.2008.06.102
CHEMBL507334 195664 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 634 12 3 5 4.8 O=C(/C=C/c1ccccc1Cl)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1 10.1016/j.bmcl.2008.06.102
11764212 91907 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 664 8 6 6 2.3 O=C1C[C@H](NC2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL224888 91907 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 664 8 6 6 2.3 O=C1C[C@H](NC2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
46237296 13545 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 630 12 2 6 5.8 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCC(CN5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083852 13545 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 630 12 2 6 5.8 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCC(CN5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46236392 13569 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 612 12 3 6 5.3 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5c[nH]cn5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083876 13569 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 612 12 3 6 5.3 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5c[nH]cn5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
9875181 178122 0 None -7 2 Guinea pig 9.0 pKi = 9 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL446146 178122 0 None -7 2 Guinea pig 9.0 pKi = 9 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
9810835 210354 0 None -7 2 Guinea pig 9.0 pKi = 9 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL66763 210354 0 None -7 2 Guinea pig 9.0 pKi = 9 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
9874206 210550 0 None -1 2 Guinea pig 9.0 pKi = 9 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL68060 210550 0 None -1 2 Guinea pig 9.0 pKi = 9 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44385249 67978 0 None - 1 Rat 9.0 pKi = 9 Binding
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 516 8 1 4 6.3 CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccsc1 10.1016/S0960-894X(00)80694-0
CHEMBL176588 67978 0 None - 1 Rat 9.0 pKi = 9 Binding
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 516 8 1 4 6.3 CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccsc1 10.1016/S0960-894X(00)80694-0
18964186 211083 0 None -3 3 Rat 9.0 pKi = 9 Binding
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 510 8 1 3 6.2 CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/S0960-894X(00)80694-0
CHEMBL71397 211083 0 None -3 3 Rat 9.0 pKi = 9 Binding
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 510 8 1 3 6.2 CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/S0960-894X(00)80694-0
23626413 99007 0 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 589 10 3 6 3.0 CN1CCN(C(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCCC2)CC1 10.1021/jm070289w
CHEMBL242625 99007 0 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 589 10 3 6 3.0 CN1CCN(C(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCCC2)CC1 10.1021/jm070289w
44315298 109888 0 None -1 3 Human 9.0 pKi = 9.0 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 721 12 0 6 7.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3ccoc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL307733 109888 0 None -1 3 Human 9.0 pKi = 9.0 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 721 12 0 6 7.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3ccoc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44337208 12011 0 None 38 2 Human 9.0 pKi = 9.0 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 635 7 2 5 4.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@@H](N)c4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL106300 12011 0 None 38 2 Human 9.0 pKi = 9.0 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 635 7 2 5 4.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@@H](N)c4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44337207 14602 0 None 10 2 Human 9.0 pKi = 9.0 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 649 8 2 5 4.8 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)Cc4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL108955 14602 0 None 10 2 Human 9.0 pKi = 9.0 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 649 8 2 5 4.8 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)Cc4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
23626569 156243 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 659 11 3 7 3.5 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N2CCN(C3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
CHEMBL394607 156243 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 659 11 3 7 3.5 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N2CCN(C3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
9831674 111188 0 None -1 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 712 12 1 6 5.9 CNC(=O)CN1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00462-6
CHEMBL310334 111188 0 None -1 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 712 12 1 6 5.9 CNC(=O)CN1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00462-6
44315370 211618 0 None -1 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 789 14 0 7 7.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(=O)OCc3ccccc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL75479 211618 0 None -1 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 789 14 0 7 7.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(=O)OCc3ccccc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44315297 211646 0 None 1 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 833 15 1 8 8.0 CCOC(=O)[C@@H](Cc1ccc(O)cc1)N1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00462-6
CHEMBL75698 211646 0 None 1 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 833 15 1 8 8.0 CCOC(=O)[C@@H](Cc1ccc(O)cc1)N1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00462-6
44315299 211790 0 None 1 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 737 12 0 6 8.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3ccsc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL76823 211790 0 None 1 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 737 12 0 6 8.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3ccsc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
10792233 183194 0 None 1 2 Human 8.9 pKi = 8.9 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 526 7 1 4 5.9 CC(C)C(=O)N1CCN(Cc2c(-c3ccccc3)nc3ccccc3c2C(=O)N[C@@H](C)C2CCCCC2)CC1 10.1021/jm000501v
CHEMBL45961 183194 0 None 1 2 Human 8.9 pKi = 8.9 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 526 7 1 4 5.9 CC(C)C(=O)N1CCN(Cc2c(-c3ccccc3)nc3ccccc3c2C(=O)N[C@@H](C)C2CCCCC2)CC1 10.1021/jm000501v
104974 10248 31 None -3 7 Golden hamster 8.9 pKi = 8.9 Binding
The compound was evaluated for the inhibition of [125I]NKA binding to neurokinin NK2 receptor from hamster urinary bladder membranesThe compound was evaluated for the inhibition of [125I]NKA binding to neurokinin NK2 receptor from hamster urinary bladder membranes
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(00)80694-0
2111 10248 31 None -3 7 Golden hamster 8.9 pKi = 8.9 Binding
The compound was evaluated for the inhibition of [125I]NKA binding to neurokinin NK2 receptor from hamster urinary bladder membranesThe compound was evaluated for the inhibition of [125I]NKA binding to neurokinin NK2 receptor from hamster urinary bladder membranes
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(00)80694-0
3481 10248 31 None -3 7 Golden hamster 8.9 pKi = 8.9 Binding
The compound was evaluated for the inhibition of [125I]NKA binding to neurokinin NK2 receptor from hamster urinary bladder membranesThe compound was evaluated for the inhibition of [125I]NKA binding to neurokinin NK2 receptor from hamster urinary bladder membranes
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(00)80694-0
CHEMBL308148 10248 31 None -3 7 Golden hamster 8.9 pKi = 8.9 Binding
The compound was evaluated for the inhibition of [125I]NKA binding to neurokinin NK2 receptor from hamster urinary bladder membranesThe compound was evaluated for the inhibition of [125I]NKA binding to neurokinin NK2 receptor from hamster urinary bladder membranes
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(00)80694-0
DB06660 10248 31 None -3 7 Golden hamster 8.9 pKi = 8.9 Binding
The compound was evaluated for the inhibition of [125I]NKA binding to neurokinin NK2 receptor from hamster urinary bladder membranesThe compound was evaluated for the inhibition of [125I]NKA binding to neurokinin NK2 receptor from hamster urinary bladder membranes
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(00)80694-0
2089 9542 28 None 102 5 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
ChEMBL None None None None 10.1021/jm401823z
3795 9542 28 None 102 5 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
ChEMBL None None None None 10.1021/jm401823z
5311311 9542 28 None 102 5 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
ChEMBL None None None None 10.1021/jm401823z
CHEMBL217406 9542 28 None 102 5 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
ChEMBL None None None None 10.1021/jm401823z
9887650 23423 0 None 1 5 Rat 8.9 pKi = 8.9 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 407 5 1 3 4.3 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccccc1 10.1021/jm00019a006
CHEMBL124208 23423 0 None 1 5 Rat 8.9 pKi = 8.9 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 407 5 1 3 4.3 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccccc1 10.1021/jm00019a006
10476440 123780 0 None - 1 Rat 8.9 pKi = 8.9 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 406 5 2 2 3.9 O=C1NC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccccc1 10.1021/jm00019a006
CHEMBL338825 123780 0 None - 1 Rat 8.9 pKi = 8.9 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 406 5 2 2 3.9 O=C1NC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccccc1 10.1021/jm00019a006
10046881 125257 0 None - 1 Rat 8.9 pKi = 8.9 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 405 5 1 2 4.4 O=C1CC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccccc1 10.1021/jm00019a006
CHEMBL341357 125257 0 None - 1 Rat 8.9 pKi = 8.9 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 405 5 1 2 4.4 O=C1CC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccccc1 10.1021/jm00019a006
10121831 96214 0 None 158 2 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 618 17 3 5 6.5 CCCCN(CCCC)CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
CHEMBL237097 96214 0 None 158 2 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 618 17 3 5 6.5 CCCCN(CCCC)CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
44434196 156003 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 594 11 3 5 4.8 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCCC2)CCc2ccccc21)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
CHEMBL394418 156003 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 594 11 3 5 4.8 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCCC2)CCc2ccccc21)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
44434203 156006 0 None 158 2 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 594 11 3 5 4.5 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCCC2)Cc2ccccc2C1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
CHEMBL394420 156006 0 None 158 2 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 594 11 3 5 4.5 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCCC2)Cc2ccccc2C1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
44577901 180239 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 634 12 3 5 4.8 O=C(/C=C/c1ccc(Cl)cc1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1 10.1016/j.bmcl.2008.06.102
CHEMBL452960 180239 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 634 12 3 5 4.8 O=C(/C=C/c1ccc(Cl)cc1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1 10.1016/j.bmcl.2008.06.102
44577902 195109 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 630 13 3 6 4.1 COc1ccccc1/C=C/C(=O)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1 10.1016/j.bmcl.2008.06.102
CHEMBL500797 195109 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 630 13 3 6 4.1 COc1ccccc1/C=C/C(=O)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1 10.1016/j.bmcl.2008.06.102
11480157 175486 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 906 16 14 15 -3.6 O=C1C[C@@H](NC[C@H](O)[C@@H](O)[C@H](O[C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O)[C@H](O)CO)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL436804 175486 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 906 16 14 15 -3.6 O=C1C[C@@H](NC[C@H](O)[C@@H](O)[C@H](O[C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O)[C@H](O)CO)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
46236649 13549 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 644 12 2 6 6.3 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCC(N(C)C5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083856 13549 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 644 12 2 6 6.3 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCC(N(C)C5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
44337355 12118 0 None 26 2 Human 8.9 pKi = 8.9 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 581 7 2 4 5.2 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4cc[nH]c4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL106877 12118 0 None 26 2 Human 8.9 pKi = 8.9 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 581 7 2 4 5.2 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4cc[nH]c4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44337174 14655 0 None 11 2 Human 8.9 pKi = 8.9 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 649 8 2 5 5.8 CC(=O)Nc1ccc(CN2CCC(NCC(=O)N3CCN(C(=O)c4cc(C)cc(C)c4)C[C@H]3c3ccc(Cl)c(Cl)c3)CC2)cc1 10.1016/s0960-894x(02)00645-5
CHEMBL108997 14655 0 None 11 2 Human 8.9 pKi = 8.9 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 649 8 2 5 5.8 CC(=O)Nc1ccc(CN2CCC(NCC(=O)N3CCN(C(=O)c4cc(C)cc(C)c4)C[C@H]3c3ccc(Cl)c(Cl)c3)CC2)cc1 10.1016/s0960-894x(02)00645-5
22861435 176276 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 489 9 1 4 6.2 CC/C(=N\O)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
CHEMBL443264 176276 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 489 9 1 4 6.2 CC/C(=N\O)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
44302497 168507 0 None - 1 Human 8.9 pKi = 8.9 Binding
Binding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligandBinding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligand
ChEMBL 1095 24 8 14 2.9 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CC(N)c1ccc([N+](=O)[O-])c2nonc12)NC(=O)c1ccccc1)C(N)=O 10.1021/jm00039a012
CHEMBL413650 168507 0 None - 1 Human 8.9 pKi = 8.9 Binding
Binding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligandBinding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligand
ChEMBL 1095 24 8 14 2.9 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CC(N)c1ccc([N+](=O)[O-])c2nonc12)NC(=O)c1ccccc1)C(N)=O 10.1021/jm00039a012
118724118 123183 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
ChEMBL 1095 25 8 14 3.3 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)C(CCNc1ccc([N+](=O)[O-])c2nonc12)NC(=O)c1ccccc1)C(N)=O 10.1021/jm401823z
CHEMBL3360196 123183 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
ChEMBL 1095 25 8 14 3.3 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)C(CCNc1ccc([N+](=O)[O-])c2nonc12)NC(=O)c1ccccc1)C(N)=O 10.1021/jm401823z
23625476 103715 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 655 11 3 7 4.8 N#Cc1ccc2cc(C(=O)NC3(C(=O)N[C@H](Cc4ccccc4)C(=O)NCC4CCN(CC5CCOCC5)CC4)CCCC3)sc2c1 10.1021/jm070289w
CHEMBL266108 103715 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 655 11 3 7 4.8 N#Cc1ccc2cc(C(=O)NC3(C(=O)N[C@H](Cc4ccccc4)C(=O)NCC4CCN(CC5CCOCC5)CC4)CCCC3)sc2c1 10.1021/jm070289w
44380526 65102 0 None 1 2 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 665 11 0 6 6.9 CN(C/C(=N\OCC#N)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL168272 65102 0 None 1 2 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 665 11 0 6 6.9 CN(C/C(=N\OCC#N)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
18964216 66665 0 None - 1 Rat 8.9 pKi = 8.9 Binding
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 516 8 1 4 6.3 CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cccs1 10.1016/S0960-894X(00)80694-0
CHEMBL173008 66665 0 None - 1 Rat 8.9 pKi = 8.9 Binding
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 516 8 1 4 6.3 CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cccs1 10.1016/S0960-894X(00)80694-0
44302414 89225 0 None - 1 Human 8.8 pKi = 8.8 Binding
Binding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligandBinding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligand
ChEMBL 1110 25 8 14 3.3 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)c1ccc([N+](=O)[O-])c2nonc12)NC(=O)c1ccccc1)C(N)=O 10.1021/jm00039a012
CHEMBL217548 89225 0 None - 1 Human 8.8 pKi = 8.8 Binding
Binding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligandBinding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligand
ChEMBL 1110 25 8 14 3.3 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)c1ccc([N+](=O)[O-])c2nonc12)NC(=O)c1ccccc1)C(N)=O 10.1021/jm00039a012
190884 123184 8 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
ChEMBL 1110 26 8 14 3.7 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CCCNc1ccc([N+](=O)[O-])c2nonc12)NC(=O)c1ccccc1)C(N)=O 10.1021/jm401823z
CHEMBL3360197 123184 8 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
ChEMBL 1110 26 8 14 3.7 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CCCNc1ccc([N+](=O)[O-])c2nonc12)NC(=O)c1ccccc1)C(N)=O 10.1021/jm401823z
44302394 104026 0 None - 1 Human 8.8 pKi = 8.8 Binding
Binding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligandBinding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligand
ChEMBL 1124 26 8 14 3.7 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CCCC(N)c1ccc([N+](=O)[O-])c2nonc12)NC(=O)c1ccccc1)C(N)=O 10.1021/jm00039a012
CHEMBL268783 104026 0 None - 1 Human 8.8 pKi = 8.8 Binding
Binding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligandBinding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligand
ChEMBL 1124 26 8 14 3.7 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CCCC(N)c1ccc([N+](=O)[O-])c2nonc12)NC(=O)c1ccccc1)C(N)=O 10.1021/jm00039a012
118724119 123185 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
ChEMBL 1174 30 9 14 4.8 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CCCCNc1ccc([N+](=O)[O-])c2nonc12)NC(=O)c1ccccc1)C(N)=O 10.1021/jm401823z
CHEMBL3360198 123185 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
ChEMBL 1174 30 9 14 4.8 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CCCCNc1ccc([N+](=O)[O-])c2nonc12)NC(=O)c1ccccc1)C(N)=O 10.1021/jm401823z
44315369 109796 0 None -1 3 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 689 10 0 7 7.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(C)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL306952 109796 0 None -1 3 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 689 10 0 7 7.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(C)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44380091 127499 0 None -2 2 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 684 13 1 6 6.8 CN(C/C(=N\OCCCO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL354772 127499 0 None -2 2 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 684 13 1 6 6.8 CN(C/C(=N\OCCCO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
10744541 108119 0 None -1 3 Human 8.8 pKi = 8.8 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 520 8 1 4 6.6 CC(C)[C@H](NC(=O)c1c(CN2CCN(C(C)C)CC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm000501v
CHEMBL296857 108119 0 None -1 3 Human 8.8 pKi = 8.8 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 520 8 1 4 6.6 CC(C)[C@H](NC(=O)c1c(CN2CCN(C(C)C)CC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm000501v
44385289 68141 0 None - 1 Rat 8.8 pKi = 8.8 Binding
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 560 8 1 3 7.4 CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cccc2ccccc12 10.1016/S0960-894X(00)80694-0
CHEMBL176853 68141 0 None - 1 Rat 8.8 pKi = 8.8 Binding
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 560 8 1 3 7.4 CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cccc2ccccc12 10.1016/S0960-894X(00)80694-0
10232331 99946 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 596 11 3 6 4.2 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2cc(Cl)ccc2s1 10.1021/jm070289w
CHEMBL244364 99946 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 596 11 3 6 4.2 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2cc(Cl)ccc2s1 10.1021/jm070289w
10342250 23706 0 None - 1 Rat 8.8 pKi = 8.8 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 423 7 2 3 3.7 CC(=O)N(Cc1ccccc1)CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1 10.1021/jm00019a006
CHEMBL125310 23706 0 None - 1 Rat 8.8 pKi = 8.8 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 423 7 2 3 3.7 CC(=O)N(Cc1ccccc1)CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1 10.1021/jm00019a006
10477484 24045 0 None - 1 Rat 8.8 pKi = 8.8 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 425 5 1 3 4.5 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1cccc(F)c1 10.1021/jm00019a006
CHEMBL125696 24045 0 None - 1 Rat 8.8 pKi = 8.8 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 425 5 1 3 4.5 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1cccc(F)c1 10.1021/jm00019a006
10722305 117096 0 None - 1 Human 8.8 pKi = 8.8 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 601 6 5 4 2.8 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(F)c(F)c2)CN1 10.1021/jm0010217
CHEMBL323884 117096 0 None - 1 Human 8.8 pKi = 8.8 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 601 6 5 4 2.8 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(F)c(F)c2)CN1 10.1021/jm0010217
44434195 95369 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 652 17 3 5 6.6 CCCCN(CCCC)CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCc2ccccc21 10.1016/j.bmcl.2007.06.053
CHEMBL235574 95369 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 652 17 3 5 6.6 CCCCN(CCCC)CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCc2ccccc21 10.1016/j.bmcl.2007.06.053
44434202 158949 0 None 125 2 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 652 17 3 5 6.3 CCCCN(CCCC)CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)Cc2ccccc2C1 10.1016/j.bmcl.2007.06.053
CHEMBL396827 158949 0 None 125 2 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 652 17 3 5 6.3 CCCCN(CCCC)CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)Cc2ccccc2C1 10.1016/j.bmcl.2007.06.053
44577905 178430 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 614 12 3 5 4.4 Cc1ccccc1/C=C/C(=O)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1 10.1016/j.bmcl.2008.06.102
CHEMBL446604 178430 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 614 12 3 5 4.4 Cc1ccccc1/C=C/C(=O)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1 10.1016/j.bmcl.2008.06.102
44374556 59505 0 None 1 2 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 773 9 5 6 3.7 O=C1C[C@@H](CC(=O)N2CCC(N3CCCCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
CHEMBL159449 59505 0 None 1 2 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 773 9 5 6 3.7 O=C1C[C@@H](CC(=O)N2CCC(N3CCCCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
44374427 61567 0 None -1 2 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 765 12 6 8 0.9 O=C1CC(C(=O)N2CCN(CCOCCO)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
CHEMBL161242 61567 0 None -1 2 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 765 12 6 8 0.9 O=C1CC(C(=O)N2CCN(CCOCCO)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
11491576 91673 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 649 7 6 6 1.4 O=C1C[C@@H](N2CCNCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL223644 91673 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 649 7 6 6 1.4 O=C1C[C@@H](N2CCNCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
11343418 91847 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 720 9 6 7 0.9 CN1CCN(CC(=O)N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
CHEMBL224427 91847 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 720 9 6 7 0.9 CN1CCN(CC(=O)N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
44421491 144048 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 882 13 11 11 -1.5 CC(=O)N[C@H]1[C@H](NC(=O)CCC(=O)N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)O[C@H](CO)[C@@H](O)[C@@H]1O 10.1021/jm040832y
CHEMBL375213 144048 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 882 13 11 11 -1.5 CC(=O)N[C@H]1[C@H](NC(=O)CCC(=O)N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)O[C@H](CO)[C@@H](O)[C@@H]1O 10.1021/jm040832y
11479743 148816 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 648 7 5 5 3.0 O=C1C[C@@H](N2CCCCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL387699 148816 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 648 7 5 5 3.0 O=C1C[C@@H](N2CCCCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
10303737 92751 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 582 12 3 5 4.0 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1ccc(-c2ccccc2)cc1 10.1021/jm070289w
CHEMBL230324 92751 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 582 12 3 5 4.0 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1ccc(-c2ccccc2)cc1 10.1021/jm070289w
118724120 123186 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
ChEMBL 1181 29 9 15 3.2 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CCCCNCC(=O)Nc1ccc([N+](=O)[O-])c2nonc12)NC(=O)c1ccccc1)C(N)=O 10.1021/jm401823z
CHEMBL3360199 123186 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
ChEMBL 1181 29 9 15 3.2 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CCCCNCC(=O)Nc1ccc([N+](=O)[O-])c2nonc12)NC(=O)c1ccccc1)C(N)=O 10.1021/jm401823z
10722305 117096 0 None - 1 Human 8.8 pKi = 8.8 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 601 6 5 4 2.8 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(F)c(F)c2)CN1 10.1021/jm011127h
CHEMBL323884 117096 0 None - 1 Human 8.8 pKi = 8.8 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 601 6 5 4 2.8 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(F)c(F)c2)CN1 10.1021/jm011127h
44343144 170799 0 None - 1 Human 8.8 pKi = 8.8 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 662 9 7 8 0.8 O=C1C[C@H](NCc2nn[nH]n2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm011127h
CHEMBL420859 170799 0 None - 1 Human 8.8 pKi = 8.8 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 662 9 7 8 0.8 O=C1C[C@H](NCc2nn[nH]n2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm011127h
9939307 210265 0 None 2 4 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL66106 210265 0 None 2 4 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
10840329 123743 0 None -1 3 Human 8.8 pKi = 8.8 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 546 8 1 4 7.2 CC[C@H](NC(=O)c1c(CN2CCN(C3CCCCC3)CC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm000501v
CHEMBL33868 123743 0 None -1 3 Human 8.8 pKi = 8.8 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 546 8 1 4 7.2 CC[C@H](NC(=O)c1c(CN2CCN(C3CCCCC3)CC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm000501v
44315390 211821 0 None -1 3 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 733 12 1 8 7.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(CC(=O)O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL77042 211821 0 None -1 3 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 733 12 1 8 7.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(CC(=O)O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44380062 127542 0 None -1 2 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 740 14 2 6 6.7 CNC(=O)NCCCO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL355295 127542 0 None -1 2 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 740 14 2 6 6.7 CNC(=O)NCCCO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
9850582 204021 22 None -1 6 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
CHEMBL56835 204021 22 None -1 6 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
44315576 212024 0 None -1 3 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 747 12 0 9 7.2 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(CC(=O)OC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL78851 212024 0 None -1 3 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 747 12 0 9 7.2 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(CC(=O)OC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
23625179 90305 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 616 10 3 6 4.7 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NC2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
CHEMBL220365 90305 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 616 10 3 6 4.7 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NC2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
23625180 99350 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 644 12 3 6 5.3 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
CHEMBL243497 99350 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 644 12 3 6 5.3 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
9829402 175279 0 None 2 2 Human 8.7 pKi = 8.7 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 565 6 5 4 2.6 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1 10.1021/jm0010217
CHEMBL435324 175279 0 None 2 2 Human 8.7 pKi = 8.7 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 565 6 5 4 2.6 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1 10.1021/jm0010217
44331128 114034 0 None - 1 Human 8.7 pKi = 8.7 Binding
Compound was tested for it's binding affinity against human Tachykinin receptor 2Compound was tested for it's binding affinity against human Tachykinin receptor 2
ChEMBL 814 12 6 9 1.4 CN(C)CCN(C)C(=O)c1nccnc1C(=O)N[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1016/s0960-894x(02)00539-5
CHEMBL316943 114034 0 None - 1 Human 8.7 pKi = 8.7 Binding
Compound was tested for it's binding affinity against human Tachykinin receptor 2Compound was tested for it's binding affinity against human Tachykinin receptor 2
ChEMBL 814 12 6 9 1.4 CN(C)CCN(C)C(=O)c1nccnc1C(=O)N[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1016/s0960-894x(02)00539-5
9829402 175279 0 None 2 2 Human 8.7 pKi = 8.7 Binding
Compound was tested for it's binding affinity against human Tachykinin receptor 2Compound was tested for it's binding affinity against human Tachykinin receptor 2
ChEMBL 565 6 5 4 2.6 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1 10.1016/s0960-894x(02)00539-5
CHEMBL435324 175279 0 None 2 2 Human 8.7 pKi = 8.7 Binding
Compound was tested for it's binding affinity against human Tachykinin receptor 2Compound was tested for it's binding affinity against human Tachykinin receptor 2
ChEMBL 565 6 5 4 2.6 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1 10.1016/s0960-894x(02)00539-5
44434194 95332 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 575 11 3 6 3.4 CN1CCN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCCC2)CC1 10.1016/j.bmcl.2007.06.053
CHEMBL235353 95332 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 575 11 3 6 3.4 CN1CCN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCCC2)CC1 10.1016/j.bmcl.2007.06.053
44434197 156005 0 None 1 2 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 610 11 3 6 4.0 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCc2ccccc21)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
CHEMBL394419 156005 0 None 1 2 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 610 11 3 6 4.0 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCc2ccccc21)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
44434204 160347 0 None 50 2 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 610 11 3 6 3.7 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)Cc2ccccc2C1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
CHEMBL398028 160347 0 None 50 2 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 610 11 3 6 3.7 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)Cc2ccccc2C1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
44577899 179738 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 618 12 3 5 4.3 O=C(/C=C/c1ccc(F)cc1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1 10.1016/j.bmcl.2008.06.102
CHEMBL451751 179738 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 618 12 3 5 4.3 O=C(/C=C/c1ccc(F)cc1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1 10.1016/j.bmcl.2008.06.102
44577904 195480 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 630 13 3 6 4.1 COc1ccc(/C=C/C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
CHEMBL504342 195480 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 630 13 3 6 4.1 COc1ccc(/C=C/C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
9829402 175279 0 None 2 2 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 565 6 5 4 2.6 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1 10.1016/s0960-894x(01)00841-1
CHEMBL435324 175279 0 None 2 2 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 565 6 5 4 2.6 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1 10.1016/s0960-894x(01)00841-1
11332007 91856 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 785 14 11 10 -1.3 CC(=O)N[C@@H](CN[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/jm040832y
CHEMBL224532 91856 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 785 14 11 10 -1.3 CC(=O)N[C@@H](CN[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/jm040832y
11377052 144649 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 580 6 6 5 1.5 N[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1021/jm040832y
CHEMBL376141 144649 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 580 6 6 5 1.5 N[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1021/jm040832y
9829402 175279 0 None 2 2 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 565 6 5 4 2.6 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1 10.1021/jm040832y
CHEMBL435324 175279 0 None 2 2 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 565 6 5 4 2.6 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1 10.1021/jm040832y
46889639 13546 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 602 10 2 6 5.2 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCN4CCC(N5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083853 13546 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 602 10 2 6 5.2 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCN4CCC(N5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46237442 13550 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 575 12 3 5 5.9 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCC(CCO)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083857 13550 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 575 12 3 5 5.9 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCC(CCO)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46236794 13552 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 602 10 2 6 5.0 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@H](Cc4ccccc4)CN4CCN(CC5CCOCC5)CC4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083859 13552 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 602 10 2 6 5.0 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@H](Cc4ccccc4)CN4CCN(CC5CCOCC5)CC4)CCCC3)sc2c1 10.1021/jm100176s
46237575 13662 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 560 11 2 5 4.5 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(C=O)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1084251 13662 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 560 11 2 5 4.5 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(C=O)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
9829402 175279 0 None 2 2 Human 8.7 pKi = 8.7 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 565 6 5 4 2.6 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1 10.1021/jm011127h
CHEMBL435324 175279 0 None 2 2 Human 8.7 pKi = 8.7 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 565 6 5 4 2.6 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1 10.1021/jm011127h
10026337 119612 0 None - 1 Rat 8.0 pKi = 8 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 441 5 1 3 5.0 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccc(Cl)cc1 10.1021/jm00019a006
CHEMBL330826 119612 0 None - 1 Rat 8.0 pKi = 8 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 441 5 1 3 5.0 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccc(Cl)cc1 10.1021/jm00019a006
10251624 125114 0 None - 1 Rat 8.0 pKi = 8 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 421 6 1 3 4.4 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1CCc1ccccc1 10.1021/jm00019a006
CHEMBL341008 125114 0 None - 1 Rat 8.0 pKi = 8 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 421 6 1 3 4.4 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1CCc1ccccc1 10.1021/jm00019a006
10069913 178088 0 None - 1 Rat 8.0 pKi = 8 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 406 5 2 3 3.6 O=C1CC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)NN1Cc1ccccc1 10.1021/jm00019a006
CHEMBL446099 178088 0 None - 1 Rat 8.0 pKi = 8 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 406 5 2 3 3.6 O=C1CC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)NN1Cc1ccccc1 10.1021/jm00019a006
44281753 106593 0 None 9 2 Human 8.0 pKi = 8 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 626 11 1 5 7.8 CO/N=C(\COCc1cc(F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL285476 106593 0 None 9 2 Human 8.0 pKi = 8 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 626 11 1 5 7.8 CO/N=C(\COCc1cc(F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44353078 103368 0 None - 1 Human 8.0 pKi = 8 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 595 7 5 5 2.6 COc1ccc(CC2CNC(=O)CCC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N2)cc1 10.1021/jm0010217
CHEMBL263194 103368 0 None - 1 Human 8.0 pKi = 8 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 595 7 5 5 2.6 COc1ccc(CC2CNC(=O)CCC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N2)cc1 10.1021/jm0010217
10579116 123213 0 None - 1 Human 8.0 pKi = 8 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 579 7 5 4 3.0 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](CCc2ccccc2)CN1 10.1021/jm0010217
CHEMBL336053 123213 0 None - 1 Human 8.0 pKi = 8 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 579 7 5 4 3.0 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](CCc2ccccc2)CN1 10.1021/jm0010217
10232566 10990 0 None - 1 Human 8.0 pKi = 8 Binding
Compound was tested for it's binding affinity against human Tachykinin receptor 2Compound was tested for it's binding affinity against human Tachykinin receptor 2
ChEMBL 607 12 2 4 6.1 CN(CCc1c[nH]c2ccccc12)C(=O)c1ccccc1C(=O)N(CCCN1CCSCC1)CCc1c[nH]c2ccccc12 10.1016/s0960-894x(02)00539-5
CHEMBL100297 10990 0 None - 1 Human 8.0 pKi = 8 Binding
Compound was tested for it's binding affinity against human Tachykinin receptor 2Compound was tested for it's binding affinity against human Tachykinin receptor 2
ChEMBL 607 12 2 4 6.1 CN(CCc1c[nH]c2ccccc12)C(=O)c1ccccc1C(=O)N(CCCN1CCSCC1)CCc1c[nH]c2ccccc12 10.1016/s0960-894x(02)00539-5
44577894 179194 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 616 12 3 5 4.8 CC(C)c1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
CHEMBL447676 179194 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 616 12 3 5 4.8 CC(C)c1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
44577889 195034 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 632 14 3 6 4.5 CCCOc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
CHEMBL499689 195034 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 632 14 3 6 4.5 CCCOc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
71461644 85672 0 None -1 2 Human 8.0 pKi = 8 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 784 10 10 10 -0.9 O=C(C[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)CNC1=O)NC1OC(CO)C(O)C(O)C1O 10.1016/s0960-894x(01)00841-1
CHEMBL2112924 85672 0 None -1 2 Human 8.0 pKi = 8 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 784 10 10 10 -0.9 O=C(C[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)CNC1=O)NC1OC(CO)C(O)C(O)C1O 10.1016/s0960-894x(01)00841-1
49863731 22102 0 None -5 3 Rat 8.0 pKi = 8 Binding
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 1266 18 10 12 6.1 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
CHEMBL1214024 22102 0 None -5 3 Rat 8.0 pKi = 8 Binding
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 1266 18 10 12 6.1 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
44343084 17269 0 None - 1 Human 8.0 pKi = 8 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 581 7 5 4 3.4 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CC2=CC=CCC2)C(=O)N[C@H](CCc2ccccc2)CN1 10.1021/jm011127h
CHEMBL116629 17269 0 None - 1 Human 8.0 pKi = 8 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 581 7 5 4 3.4 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CC2=CC=CCC2)C(=O)N[C@H](CCc2ccccc2)CN1 10.1021/jm011127h
23625471 150648 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 590 11 2 6 4.2 CN(C(=O)c1cc2ccccc2s1)C1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCCC1 10.1021/jm070289w
CHEMBL390174 150648 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 590 11 2 6 4.2 CN(C(=O)c1cc2ccccc2s1)C1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCCC1 10.1021/jm070289w
23625784 93038 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 605 11 4 5 4.2 O=C(NCCCN1CCOCC1)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=S)Nc2ccc(Cl)c(Cl)c2)CCCC1 10.1021/jm070289w
CHEMBL231261 93038 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 605 11 4 5 4.2 O=C(NCCCN1CCOCC1)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=S)Nc2ccc(Cl)c(Cl)c2)CCCC1 10.1021/jm070289w
10001491 124830 0 None - 1 Rat 7.0 pKi = 7 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 408 5 1 4 3.7 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccncc1 10.1021/jm00019a006
CHEMBL340405 124830 0 None - 1 Rat 7.0 pKi = 7 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 408 5 1 4 3.7 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccncc1 10.1021/jm00019a006
11743532 124889 0 None - 1 Rat 7.0 pKi = 7 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 432 5 1 4 4.2 N#Cc1ccc(CN2CC3(CCN(CCc4c[nH]c5ccc(F)cc45)CC3)OC2=O)cc1 10.1021/jm00019a006
CHEMBL340747 124889 0 None - 1 Rat 7.0 pKi = 7 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 432 5 1 4 4.2 N#Cc1ccc(CN2CC3(CCN(CCc4c[nH]c5ccc(F)cc45)CC3)OC2=O)cc1 10.1021/jm00019a006
10407490 175332 0 None - 1 Rat 7.0 pKi = 7 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 381 7 3 3 3.5 OC1(CNCc2ccccc2)CCN(CCc2c[nH]c3ccc(F)cc23)CC1 10.1021/jm00019a006
CHEMBL435619 175332 0 None - 1 Rat 7.0 pKi = 7 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 381 7 3 3 3.5 OC1(CNCc2ccccc2)CCN(CCc2c[nH]c3ccc(F)cc23)CC1 10.1021/jm00019a006
44391105 72402 0 None - 1 Human 7.0 pKi = 7 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 516 12 3 5 3.8 O=C(Nc1ccc(OCc2ccccc2)cc1)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL183414 72402 0 None - 1 Human 7.0 pKi = 7 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 516 12 3 5 3.8 O=C(Nc1ccc(OCc2ccccc2)cc1)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
44281391 106756 0 None - 1 Human 7.0 pKi = 7 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 688 11 1 5 9.2 CO/N=C(\CO/C=C/c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL286589 106756 0 None - 1 Human 7.0 pKi = 7 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 688 11 1 5 9.2 CO/N=C(\CO/C=C/c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44434175 95952 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 540 15 4 7 2.2 CC(C)(NC(=O)c1cc2ccccc2s1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCCOCCOCCN 10.1016/j.bmcl.2007.06.053
CHEMBL236659 95952 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 540 15 4 7 2.2 CC(C)(NC(=O)c1cc2ccccc2s1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCCOCCOCCN 10.1016/j.bmcl.2007.06.053
44434178 96085 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 562 13 3 5 4.9 CCN(CC)CCCNC(=O)C(Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
CHEMBL236873 96085 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 562 13 3 5 4.9 CCN(CC)CCCNC(=O)C(Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
44434182 96209 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 548 12 3 5 4.5 CCN(CC)CCNC(=O)C(Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
CHEMBL237081 96209 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 548 12 3 5 4.5 CCN(CC)CCNC(=O)C(Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
44434192 96210 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 589 11 3 6 3.8 CN1CCN(CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCCCC2)CC1 10.1016/j.bmcl.2007.06.053
CHEMBL237082 96210 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 589 11 3 6 3.8 CN1CCN(CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCCCC2)CC1 10.1016/j.bmcl.2007.06.053
44434187 96380 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 562 10 3 6 3.5 O=C(NC1(C(=O)NC(Cc2ccccc2)C(=O)NCCN2CCOCC2)CCCCC1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
CHEMBL237516 96380 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 562 10 3 6 3.5 O=C(NC1(C(=O)NC(Cc2ccccc2)C(=O)NCCN2CCOCC2)CCCCC1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
44434197 156005 0 None 1 2 Human 7.0 pKi = 7 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 610 11 3 6 4.0 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCc2ccccc21)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
CHEMBL394419 156005 0 None 1 2 Human 7.0 pKi = 7 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 610 11 3 6 4.0 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCc2ccccc21)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
44434179 173832 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 562 14 4 5 5.1 NCCCCCCCNC(=O)C(Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
CHEMBL428906 173832 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 562 14 4 5 5.1 NCCCCCCCNC(=O)C(Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
44301551 108584 0 None - 1 Rat 6.0 pKi = 6 Binding
Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon
ChEMBL 342 8 3 3 3.2 Cc1ccccc1OCC(O)CNCCc1c[nH]c2ccc(F)cc12 10.1016/S0960-894X(01)80541-2
CHEMBL300174 108584 0 None - 1 Rat 6.0 pKi = 6 Binding
Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon
ChEMBL 342 8 3 3 3.2 Cc1ccccc1OCC(O)CNCCc1c[nH]c2ccc(F)cc12 10.1016/S0960-894X(01)80541-2
44391061 71631 0 None - 1 Human 6.0 pKi = 6 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 502 11 3 5 4.1 O=C(Nc1ccc(Oc2ccccc2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL182104 71631 0 None - 1 Human 6.0 pKi = 6 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 502 11 3 5 4.1 O=C(Nc1ccc(Oc2ccccc2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
23625323 99138 0 None - 1 Human 6.0 pKi = 6 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 522 11 2 6 2.5 CN(CC(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1)C(=O)c1cc2ccccc2s1 10.1021/jm070289w
CHEMBL243069 99138 0 None - 1 Human 6.0 pKi = 6 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 522 11 2 6 2.5 CN(CC(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1)C(=O)c1cc2ccccc2s1 10.1021/jm070289w
44391019 70654 0 None - 1 Human 5.0 pKi = 5 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 529 12 2 5 4.1 CC(C)(Oc1cccc(-c2ccccc2)c1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL180396 70654 0 None - 1 Human 5.0 pKi = 5 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 529 12 2 5 4.1 CC(C)(Oc1cccc(-c2ccccc2)c1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
51351496 67382 7 None -18 4 Human 5.0 pKi = 5 Binding
Binding affinity to human NK2 receptor by radioligand binding assayBinding affinity to human NK2 receptor by radioligand binding assay
ChEMBL 410 4 0 5 3.7 COc1ccccc1N1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)nn2C)CC1 10.1016/j.bmcl.2011.02.033
CHEMBL1760205 67382 7 None -18 4 Human 5.0 pKi = 5 Binding
Binding affinity to human NK2 receptor by radioligand binding assayBinding affinity to human NK2 receptor by radioligand binding assay
ChEMBL 410 4 0 5 3.7 COc1ccccc1N1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)nn2C)CC1 10.1016/j.bmcl.2011.02.033
90417914 125643 0 None -3235 5 Human 5.0 pKi = 5 Binding
Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysisDisplacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysis
ChEMBL 433 4 0 7 5.0 CC(C)c1nc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)co1 10.1021/jm5017413
CHEMBL3422015 125643 0 None -3235 5 Human 5.0 pKi = 5 Binding
Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysisDisplacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysis
ChEMBL 433 4 0 7 5.0 CC(C)c1nc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)co1 10.1021/jm5017413
44434159 152575 0 None - 1 Human 5.0 pKi = 5 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 562 11 4 5 4.1 CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1)C(N)=O 10.1016/j.bmcl.2007.06.053
CHEMBL391696 152575 0 None - 1 Human 5.0 pKi = 5 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 562 11 4 5 4.1 CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1)C(N)=O 10.1016/j.bmcl.2007.06.053
44392497 71783 0 None - 1 Human 5.0 pKi = 5 Binding
Ki for human Neurokinin 2 receptorKi for human Neurokinin 2 receptor
ChEMBL 535 7 0 3 6.1 O=C1CC[C@](CCN2CC(N3CCC(F)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1C1(C2CC2)CCCC1 10.1016/j.bmcl.2005.05.134
CHEMBL182317 71783 0 None - 1 Human 5.0 pKi = 5 Binding
Ki for human Neurokinin 2 receptorKi for human Neurokinin 2 receptor
ChEMBL 535 7 0 3 6.1 O=C1CC[C@](CCN2CC(N3CCC(F)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1C1(C2CC2)CCCC1 10.1016/j.bmcl.2005.05.134
57391133 75142 0 None -1 2 Human 4.0 pKi = 4 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHO cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHO cells
ChEMBL 691 12 3 7 4.4 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)N2C(=O)C(NC(=O)OCc2ccccc2)C1 10.1016/j.ejmech.2011.08.042
CHEMBL1916635 75142 0 None -1 2 Human 4.0 pKi = 4 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHO cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHO cells
ChEMBL 691 12 3 7 4.4 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)N2C(=O)C(NC(=O)OCc2ccccc2)C1 10.1016/j.ejmech.2011.08.042
2098 10466 36 None -457 6 Human 7.0 pKi = 7.0 Binding
The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
36511 10466 36 None -457 6 Human 7.0 pKi = 7.0 Binding
The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
3805 10466 36 None -457 6 Human 7.0 pKi = 7.0 Binding
The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
3835 10466 36 None -457 6 Human 7.0 pKi = 7.0 Binding
The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
CHEMBL235363 10466 36 None -457 6 Human 7.0 pKi = 7.0 Binding
The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
10232846 120893 0 None -11 2 Human 7.0 pKi = 7.0 Binding
In vitro binding affinity towards Human Tachykinin receptor 2In vitro binding affinity towards Human Tachykinin receptor 2
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
CHEMBL332793 120893 0 None -11 2 Human 7.0 pKi = 7.0 Binding
In vitro binding affinity towards Human Tachykinin receptor 2In vitro binding affinity towards Human Tachykinin receptor 2
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
CHEMBL411905 219741 0 None - 1 Human 6.0 pKi = 6.0 Binding
Binding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligandBinding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligand
ChEMBL None None None CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](C)/N=C(/S)Nc1ccc2c(c1)C(=O)OC21c2ccc(O)cc2Oc2cc(O)ccc21)C(N)=O 10.1021/jm00039a012
44380763 126811 0 None -1 2 Human 7.0 pKi = 7.0 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 690 12 1 5 9.1 CCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL350360 126811 0 None -1 2 Human 7.0 pKi = 7.0 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 690 12 1 5 9.1 CCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
5353853 24758 47 None -14 15 Human 6.0 pKi = 6.0 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 427 6 0 4 6.1 Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
9556529 24758 47 None -14 15 Human 6.0 pKi = 6.0 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 427 6 0 4 6.1 Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL1262 24758 47 None -14 15 Human 6.0 pKi = 6.0 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 427 6 0 4 6.1 Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
25221995 203630 0 None -40 4 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cellsDisplacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cells
ChEMBL 601 8 0 3 6.5 CN(Cc1ccc(F)c(C(F)(F)F)c1)C(=O)C(C)(CCN1CCC(N2CCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm900948q
CHEMBL565894 203630 0 None -40 4 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cellsDisplacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cells
ChEMBL 601 8 0 3 6.5 CN(Cc1ccc(F)c(C(F)(F)F)c1)C(=O)C(C)(CCN1CCC(N2CCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm900948q
10010096 106666 0 None -1 2 Human 8.0 pKi = 8.0 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 719 10 1 6 8.6 CO/N=C(\CN(C)C(=O)Oc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL285986 106666 0 None -1 2 Human 8.0 pKi = 8.0 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 719 10 1 6 8.6 CO/N=C(\CN(C)C(=O)Oc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44215303 125740 0 None 1 2 Human 8.0 pKi = 8.0 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 710 12 1 6 7.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC(C(N)=O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL342341 125740 0 None 1 2 Human 8.0 pKi = 8.0 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 710 12 1 6 7.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC(C(N)=O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44363952 127789 0 None 1 2 Human 8.0 pKi = 8.0 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 696 12 1 6 7.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCC[C@H]2C(N)=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL356508 127789 0 None 1 2 Human 8.0 pKi = 8.0 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 696 12 1 6 7.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCC[C@H]2C(N)=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44380069 64391 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 714 14 0 6 8.1 CSCCCO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL166842 64391 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 714 14 0 6 8.1 CSCCCO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44266459 11293 0 None -91 2 Human 7.0 pKi = 7.0 Binding
Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 381 5 2 3 5.4 CC[C@@H](NC(=O)c1c(N)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm980633c
CHEMBL10224 11293 0 None -91 2 Human 7.0 pKi = 7.0 Binding
Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 381 5 2 3 5.4 CC[C@@H](NC(=O)c1c(N)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm980633c
44281392 106734 0 None -3 2 Human 6.9 pKi = 6.9 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 690 12 1 5 8.8 CO/N=C(\COCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL286433 106734 0 None -3 2 Human 6.9 pKi = 6.9 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 690 12 1 5 8.8 CO/N=C(\COCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281722 118168 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 590 11 1 5 7.8 CO/N=C(\COCc1ccc2ccccc2c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32717 118168 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 590 11 1 5 7.8 CO/N=C(\COCc1ccc2ccccc2c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44215305 126032 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 695 12 0 5 8.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL343627 126032 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 695 12 0 5 8.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
10002284 23653 0 None - 1 Rat 7.9 pKi = 7.9 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 421 5 1 3 4.6 Cc1ccccc1CN1CC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)OC1=O 10.1021/jm00019a006
CHEMBL125001 23653 0 None - 1 Rat 7.9 pKi = 7.9 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 421 5 1 3 4.6 Cc1ccccc1CN1CC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)OC1=O 10.1021/jm00019a006
44434168 95528 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 580 15 4 7 3.2 NCCOCCOCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
CHEMBL236250 95528 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 580 15 4 7 3.2 NCCOCCOCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
90663622 113486 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 614 15 4 7 3.3 NCCOCCOCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCc2ccccc21 10.1016/j.bmcl.2007.06.053
CHEMBL3143848 113486 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 614 15 4 7 3.3 NCCOCCOCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCc2ccccc21 10.1016/j.bmcl.2007.06.053
44577891 195455 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 646 15 3 6 4.9 CCCCOc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
CHEMBL503837 195455 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 646 15 3 6 4.9 CCCCOc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
23625633 99355 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 599 11 4 5 3.4 O=C(Nc1ccc(Br)cc1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1 10.1021/jm070289w
CHEMBL243502 99355 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 599 11 4 5 3.4 O=C(Nc1ccc(Br)cc1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1 10.1021/jm070289w
44342868 17333 0 None - 1 Human 7.9 pKi = 7.9 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 680 10 7 6 1.5 O=C(O)CCC(=O)N[C@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1021/jm011127h
CHEMBL116969 17333 0 None - 1 Human 7.9 pKi = 7.9 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 680 10 7 6 1.5 O=C(O)CCC(=O)N[C@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1021/jm011127h
44342903 117085 0 None - 1 Human 7.9 pKi = 7.9 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 597 7 5 5 3.0 COc1ccc(C[C@@H]2CNC(=O)CCC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CC3=CC=CCC3)C(=O)N2)cc1 10.1021/jm011127h
CHEMBL323836 117085 0 None - 1 Human 7.9 pKi = 7.9 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 597 7 5 5 3.0 COc1ccc(C[C@@H]2CNC(=O)CCC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CC3=CC=CCC3)C(=O)N2)cc1 10.1021/jm011127h
CHEMBL431641 220405 0 None - 1 Human 7.9 pKi = 7.9 Binding
The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2
ChEMBL None None None CC(C)CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(C)C)C(N)=O 10.1021/jm9807151
44390541 70813 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 558 11 3 5 5.3 CC(C)(C)c1ccc(Oc2ccc(NC(=O)N[C@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc1 10.1016/j.bmcl.2004.11.045
CHEMBL180725 70813 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 558 11 3 5 5.3 CC(C)(C)c1ccc(Oc2ccc(NC(=O)N[C@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc1 10.1016/j.bmcl.2004.11.045
44391089 71050 0 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 516 12 3 5 3.8 O=C(Nc1ccc(OCc2ccccc2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL180942 71050 0 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 516 12 3 5 3.8 O=C(Nc1ccc(OCc2ccccc2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL5092328 222138 5 None 6 4 Human 5.9 pKi = 5.9 Binding
Displacement of [125I]NKA from human recombinant NK2 receptor after 60 mins by scintillation counting analysisDisplacement of [125I]NKA from human recombinant NK2 receptor after 60 mins by scintillation counting analysis
ChEMBL None None None CCS(=O)(=O)[C@]1(C)CC[C@@](CF)(c2cc(NC(=O)c3cc4c(cn3)OC(F)(F)O4)ccc2F)N=C1N 10.1021/acs.jmedchem.1c00935
8867347 67377 5 None -10 4 Human 4.9 pKi = 4.9 Binding
Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor
ChEMBL 362 4 1 4 3.0 COc1ccccc1N1CCN(C(=O)c2cc(-c3ccccc3)n[nH]2)CC1 10.1016/j.bmcl.2011.02.033
CHEMBL1760200 67377 5 None -10 4 Human 4.9 pKi = 4.9 Binding
Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor
ChEMBL 362 4 1 4 3.0 COc1ccccc1N1CCN(C(=O)c2cc(-c3ccccc3)n[nH]2)CC1 10.1016/j.bmcl.2011.02.033
44305793 107622 0 None -5 2 Human 6.9 pKi = 6.9 Binding
Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand
ChEMBL 662 10 2 5 8.5 O/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL293432 107622 0 None -5 2 Human 6.9 pKi = 6.9 Binding
Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand
ChEMBL 662 10 2 5 8.5 O/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
6604014 214627 7 None -28 2 Human 5.9 pKi = 5.9 Binding
Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)
ChEMBL 396 5 1 4 4.5 COC(=O)[C@@H](NC(=O)c1cc(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm9602423
CHEMBL9643 214627 7 None -28 2 Human 5.9 pKi = 5.9 Binding
Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)
ChEMBL 396 5 1 4 4.5 COC(=O)[C@@H](NC(=O)c1cc(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm9602423
5764 10270 46 None -58 2 Human 5.9 pKi = 5.9 Binding
Inhibition of [125I]neurokinin A (NKA) binding in human Tachykinin receptor 2 of chinese hamster ovary (hNK-2-CHO) cell membranes.Inhibition of [125I]neurokinin A (NKA) binding in human Tachykinin receptor 2 of chinese hamster ovary (hNK-2-CHO) cell membranes.
ChEMBL 396 5 1 4 4.5 COC(=O)[C@@H](c1ccccc1)NC(=O)c1cc(nc2c1cccc2)c1ccccc1 10.1021/jm960818o
6604858 10270 46 None -58 2 Human 5.9 pKi = 5.9 Binding
Inhibition of [125I]neurokinin A (NKA) binding in human Tachykinin receptor 2 of chinese hamster ovary (hNK-2-CHO) cell membranes.Inhibition of [125I]neurokinin A (NKA) binding in human Tachykinin receptor 2 of chinese hamster ovary (hNK-2-CHO) cell membranes.
ChEMBL 396 5 1 4 4.5 COC(=O)[C@@H](c1ccccc1)NC(=O)c1cc(nc2c1cccc2)c1ccccc1 10.1021/jm960818o
CHEMBL9843 10270 46 None -58 2 Human 5.9 pKi = 5.9 Binding
Inhibition of [125I]neurokinin A (NKA) binding in human Tachykinin receptor 2 of chinese hamster ovary (hNK-2-CHO) cell membranes.Inhibition of [125I]neurokinin A (NKA) binding in human Tachykinin receptor 2 of chinese hamster ovary (hNK-2-CHO) cell membranes.
ChEMBL 396 5 1 4 4.5 COC(=O)[C@@H](c1ccccc1)NC(=O)c1cc(nc2c1cccc2)c1ccccc1 10.1021/jm960818o
1016 10519 78 None -16 35 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
2561 10519 78 None -16 35 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
2733526 10519 78 None -16 35 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
5384 10519 78 None -16 35 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
CHEMBL83 10519 78 None -16 35 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
DB00675 10519 78 None -16 35 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
23625473 173554 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 540 11 3 5 2.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cccc(Cl)c1 10.1021/jm070289w
CHEMBL428394 173554 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 540 11 3 5 2.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cccc(Cl)c1 10.1021/jm070289w
19610193 114009 0 None -1 2 Human 6.9 pKi = 6.9 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 654 10 1 7 5.3 COc1cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(02)00645-5
CHEMBL316740 114009 0 None -1 2 Human 6.9 pKi = 6.9 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 654 10 1 7 5.3 COc1cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(02)00645-5
10454808 175329 0 None - 1 Rat 6.9 pKi = 6.9 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 420 5 2 3 3.4 O=C1NC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)C(=O)N1Cc1ccccc1 10.1021/jm00019a006
CHEMBL435610 175329 0 None - 1 Rat 6.9 pKi = 6.9 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 420 5 2 3 3.4 O=C1NC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)C(=O)N1Cc1ccccc1 10.1021/jm00019a006
44331223 215170 0 None - 1 Human 6.9 pKi = 6.9 Binding
Compound was tested for it's binding affinity against human Tachykinin receptor 2Compound was tested for it's binding affinity against human Tachykinin receptor 2
ChEMBL 706 16 2 8 4.3 O=C(c1nccnc1C(=O)N(CCCN1CCOCC1)CCc1c[nH]c2ccccc12)N(CCCN1CCOCC1)CCc1c[nH]c2ccccc12 10.1016/s0960-894x(02)00539-5
CHEMBL99608 215170 0 None - 1 Human 6.9 pKi = 6.9 Binding
Compound was tested for it's binding affinity against human Tachykinin receptor 2Compound was tested for it's binding affinity against human Tachykinin receptor 2
ChEMBL 706 16 2 8 4.3 O=C(c1nccnc1C(=O)N(CCCN1CCOCC1)CCc1c[nH]c2ccccc12)N(CCCN1CCOCC1)CCc1c[nH]c2ccccc12 10.1016/s0960-894x(02)00539-5
44434169 95818 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 568 10 4 5 4.8 NCc1ccc(CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCCCC2)cc1 10.1016/j.bmcl.2007.06.053
CHEMBL236458 95818 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 568 10 4 5 4.8 NCc1ccc(CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCCCC2)cc1 10.1016/j.bmcl.2007.06.053
44434181 96088 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 576 15 4 5 5.5 NCCCCCCCCNC(=O)C(Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
CHEMBL236874 96088 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 576 15 4 5 5.5 NCCCCCCCCNC(=O)C(Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
10995343 27618 0 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 565 6 5 4 2.6 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC(Cc2ccccc2)CN1 10.1021/jm0010217
CHEMBL131024 27618 0 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 565 6 5 4 2.6 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC(Cc2ccccc2)CN1 10.1021/jm0010217
10554969 85275 0 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 565 6 5 4 2.6 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC[C@H](Cc2ccccc2)N1 10.1021/jm0010217
CHEMBL2111858 85275 0 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 565 6 5 4 2.6 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC[C@H](Cc2ccccc2)N1 10.1021/jm0010217
11801084 85558 0 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 565 6 5 4 2.6 O=C1CCC(=O)N[C@H](Cc2ccccc2)CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm0010217
CHEMBL2112669 85558 0 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 565 6 5 4 2.6 O=C1CCC(=O)N[C@H](Cc2ccccc2)CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm0010217
10576528 117262 0 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 475 4 5 4 0.9 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCN1 10.1021/jm0010217
CHEMBL324804 117262 0 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 475 4 5 4 0.9 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCN1 10.1021/jm0010217
10576528 117262 0 None - 1 Human 5.9 pKi = 5.9 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 475 4 5 4 0.9 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCN1 10.1021/jm011127h
CHEMBL324804 117262 0 None - 1 Human 5.9 pKi = 5.9 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 475 4 5 4 0.9 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCN1 10.1021/jm011127h
71533722 125638 0 None -933 5 Human 4.9 pKi = 4.9 Binding
Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysisDisplacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysis
ChEMBL 421 3 0 7 4.7 Cc1nc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)cs1 10.1021/jm5017413
CHEMBL3422010 125638 0 None -933 5 Human 4.9 pKi = 4.9 Binding
Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysisDisplacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysis
ChEMBL 421 3 0 7 4.7 Cc1nc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)cs1 10.1021/jm5017413
71549769 125646 0 None -3981 5 Human 4.9 pKi = 4.9 Binding
Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysisDisplacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysis
ChEMBL 422 3 0 8 4.1 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)n1 10.1021/jm5017413
CHEMBL3422018 125646 0 None -3981 5 Human 4.9 pKi = 4.9 Binding
Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysisDisplacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysis
ChEMBL 422 3 0 8 4.1 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)n1 10.1021/jm5017413
44312761 110354 0 None - 1 Human 4.9 pKi = 4.9 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 576 12 0 8 6.0 CCOC(=O)C1=C(C)OC2OC(COCc3ccccc3)C(OCc3ccccc3)C(OCc3ccccc3)C2S1 10.1016/s0960-894x(02)00471-7
CHEMBL308613 110354 0 None - 1 Human 4.9 pKi = 4.9 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 576 12 0 8 6.0 CCOC(=O)C1=C(C)OC2OC(COCc3ccccc3)C(OCc3ccccc3)C(OCc3ccccc3)C2S1 10.1016/s0960-894x(02)00471-7
44312564 211341 0 None - 1 Human 4.9 pKi = 4.9 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 486 9 1 8 3.8 CCOC(=O)C1=C(C)OC2OC(COCc3ccccc3)C(OCc3ccccc3)C(O)C2S1 10.1016/s0960-894x(02)00471-7
CHEMBL72979 211341 0 None - 1 Human 4.9 pKi = 4.9 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 486 9 1 8 3.8 CCOC(=O)C1=C(C)OC2OC(COCc3ccccc3)C(OCc3ccccc3)C(O)C2S1 10.1016/s0960-894x(02)00471-7
1836 9370 59 None -40 15 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 nan
3340 9370 59 None -40 15 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 nan
5281040 9370 59 None -40 15 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 nan
CHEMBL787 9370 59 None -40 15 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 nan
DB00471 9370 59 None -40 15 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 nan
44314834 211928 0 None -2 2 Human 6.9 pKi = 6.9 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 667 11 0 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(C2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL78092 211928 0 None -2 2 Human 6.9 pKi = 6.9 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 667 11 0 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(C2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44281359 117346 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 546 11 1 5 7.1 CO/N=C(\COCC1CCCCC1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32533 117346 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 546 11 1 5 7.1 CO/N=C(\COCC1CCCCC1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
9987474 211612 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 726 13 1 7 6.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CC[C@H](CO)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL75436 211612 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 726 13 1 7 6.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CC[C@H](CO)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
22405758 203845 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 476 9 1 3 5.7 CCC(O)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
CHEMBL56739 203845 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 476 9 1 3 5.7 CCC(O)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
44390601 71049 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 536 11 3 5 4.5 O=C(Nc1ccc(Sc2ccc(F)cc2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL180940 71049 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 536 11 3 5 4.5 O=C(Nc1ccc(Sc2ccc(F)cc2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
44281785 118140 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 652 11 1 5 9.3 CO/N=C(\COCc1cc(C(C)(C)C)cc(C(C)(C)C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32700 118140 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 652 11 1 5 9.3 CO/N=C(\COCc1cc(C(C)(C)C)cc(C(C)(C)C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44282004 128539 0 None -2 2 Human 6.9 pKi = 6.9 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 675 11 2 5 8.3 CO/N=C(\CNCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL35891 128539 0 None -2 2 Human 6.9 pKi = 6.9 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 675 11 2 5 8.3 CO/N=C(\CNCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
51351504 67383 1 None -34 4 Human 4.9 pKi = 4.9 Binding
Binding affinity to human NK2 receptor by radioligand binding assayBinding affinity to human NK2 receptor by radioligand binding assay
ChEMBL 410 4 0 5 3.7 COc1ccccc1N1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)n(C)n2)CC1 10.1016/j.bmcl.2011.02.033
CHEMBL1760206 67383 1 None -34 4 Human 4.9 pKi = 4.9 Binding
Binding affinity to human NK2 receptor by radioligand binding assayBinding affinity to human NK2 receptor by radioligand binding assay
ChEMBL 410 4 0 5 3.7 COc1ccccc1N1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)n(C)n2)CC1 10.1016/j.bmcl.2011.02.033
2351 10059 64 None -13 21 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O nan
2820 10059 64 None -13 21 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O nan
5035 10059 64 None -13 21 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O nan
CHEMBL81 10059 64 None -13 21 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O nan
DB00481 10059 64 None -13 21 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O nan
132837 9018 55 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm100157m
9461 9018 55 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm100157m
CHEMBL22870 9018 55 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm100157m
133 9274 52 None -165 43 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C nan
1723 9274 52 None -165 43 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C nan
28693 9274 52 None -165 43 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C nan
CHEMBL19215 9274 52 None -165 43 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C nan
DB13520 9274 52 None -165 43 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C nan
44281397 169747 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 554 11 1 5 7.0 CO/N=C(\COCc1ccccc1C)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL417490 169747 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 554 11 1 5 7.0 CO/N=C(\COCc1ccccc1C)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44364001 46678 0 None -1 2 Human 6.9 pKi = 6.9 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 717 13 1 5 8.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CNC(=O)c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL147767 46678 0 None -1 2 Human 6.9 pKi = 6.9 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 717 13 1 5 8.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CNC(=O)c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
3598 194600 76 None -1 7 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 404 2 2 2 6.6 Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl nan
CHEMBL496 194600 76 None -1 7 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 404 2 2 2 6.6 Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl nan
1024 8072 71 None - 1 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL None None None None nan
162639143 8072 71 None - 1 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL None None None None nan
5284373 8072 71 None - 1 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL None None None None nan
760 8072 71 None - 1 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL None None None None nan
CHEMBL160 8072 71 None - 1 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL None None None None nan
DB00091 8072 71 None - 1 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL None None None None nan
44380732 65766 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 706 13 2 6 8.1 OCCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL169002 65766 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 706 13 2 6 8.1 OCCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44337371 12063 0 None -4 2 Human 7.9 pKi = 7.9 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 720 7 1 4 6.8 O=C(c1cc(Br)cc(Br)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL106572 12063 0 None -4 2 Human 7.9 pKi = 7.9 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 720 7 1 4 6.8 O=C(c1cc(Br)cc(Br)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
44337288 14817 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 632 7 1 4 6.6 O=C(c1cc(Cl)cc(Cl)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL109092 14817 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 632 7 1 4 6.6 O=C(c1cc(Cl)cc(Cl)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
44281345 117257 0 None 10 2 Human 7.9 pKi = 7.9 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 554 11 1 5 7.0 CO/N=C(\COCc1cccc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32477 117257 0 None 10 2 Human 7.9 pKi = 7.9 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 554 11 1 5 7.0 CO/N=C(\COCc1cccc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44215306 43948 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 725 14 1 6 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2CCO)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL145302 43948 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 725 14 1 6 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2CCO)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
23625475 99338 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 632 11 3 5 2.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1ccc(I)cc1 10.1021/jm070289w
CHEMBL243280 99338 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 632 11 3 5 2.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1ccc(I)cc1 10.1021/jm070289w
155565189 182344 0 None 2 4 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter methodDisplacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter method
ChEMBL 634 7 0 9 6.2 CC(C)CCO[C@H]1[C@H]2CCN(CCc3ccc4ccccc4c3)CCCCCCOCc3cn(nn3)C[C@@H](O2)[C@@H]2OC(C)(C)O[C@H]12 10.1016/j.ejmech.2019.04.064
CHEMBL4579120 182344 0 None 2 4 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter methodDisplacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter method
ChEMBL 634 7 0 9 6.2 CC(C)CCO[C@H]1[C@H]2CCN(CCc3ccc4ccccc4c3)CCCCCCOCc3cn(nn3)C[C@@H](O2)[C@@H]2OC(C)(C)O[C@H]12 10.1016/j.ejmech.2019.04.064
71533722 125638 0 None -933 5 Human 4.9 pKi = 4.9 Binding
Binding Assay: The affinity of compounds of the invention for the NK2 receptor was evaluated in CHO recombinant cells which express the human NK2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK2 receptor was evaluated in CHO recombinant cells which express the human NK2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 421 3 0 7 4.7 Cc1nc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)cs1 nan
CHEMBL3422010 125638 0 None -933 5 Human 4.9 pKi = 4.9 Binding
Binding Assay: The affinity of compounds of the invention for the NK2 receptor was evaluated in CHO recombinant cells which express the human NK2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK2 receptor was evaluated in CHO recombinant cells which express the human NK2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 421 3 0 7 4.7 Cc1nc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)cs1 nan
44300668 204604 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 448 8 1 3 4.9 CN(CC(CCN1CCC(CO)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(98)00037-7
CHEMBL57224 204604 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 448 8 1 3 4.9 CN(CC(CCN1CCC(CO)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(98)00037-7
CHEMBL102128 215233 0 None - 1 Human 5.9 pKi = 5.9 Binding
The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2
ChEMBL None None None CC(C)CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(C)C)C(N)=O 10.1021/jm9807151
2132 10516 58 None -97 6 Human 6.8 pKi = 6.8 Binding
Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)
ChEMBL 382 5 2 3 5.5 CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1 10.1021/jm9602423
5311424 10516 58 None -97 6 Human 6.8 pKi = 6.8 Binding
Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)
ChEMBL 382 5 2 3 5.5 CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1 10.1021/jm9602423
CHEMBL10188 10516 58 None -97 6 Human 6.8 pKi = 6.8 Binding
Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)
ChEMBL 382 5 2 3 5.5 CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1 10.1021/jm9602423
44363756 46611 0 None -8 2 Human 6.8 pKi = 6.8 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 703 12 1 5 8.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(NC(=O)c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL147715 46611 0 None -8 2 Human 6.8 pKi = 6.8 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 703 12 1 5 8.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(NC(=O)c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
10691318 174392 4 None -102 2 Human 6.8 pKi = 6.8 Binding
Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 382 5 2 3 5.5 CC[C@@H](NC(=O)c1c(O)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm980633c
CHEMBL430118 174392 4 None -102 2 Human 6.8 pKi = 6.8 Binding
Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 382 5 2 3 5.5 CC[C@@H](NC(=O)c1c(O)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm980633c
2132 10516 58 None -97 6 Human 6.8 pKi = 6.8 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 382 5 2 3 5.5 CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1 10.1021/jm000501v
5311424 10516 58 None -97 6 Human 6.8 pKi = 6.8 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 382 5 2 3 5.5 CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1 10.1021/jm000501v
CHEMBL10188 10516 58 None -97 6 Human 6.8 pKi = 6.8 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 382 5 2 3 5.5 CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1 10.1021/jm000501v
44363877 45924 0 None -3 2 Human 6.8 pKi = 6.8 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 709 12 1 5 8.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(NC(=O)C2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL146947 45924 0 None -3 2 Human 6.8 pKi = 6.8 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 709 12 1 5 8.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(NC(=O)C2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44281538 117090 0 None -1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 696 11 1 5 8.2 CO/N=C(\COCc1cc(Br)cc(Br)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32385 117090 0 None -1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 696 11 1 5 8.2 CO/N=C(\COCc1cc(Br)cc(Br)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44363442 44714 0 None -1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 697 12 1 6 8.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCCC2CO)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL145959 44714 0 None -1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 697 12 1 6 8.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCCC2CO)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44329517 215056 0 None 36 2 Golden hamster 7.8 pKi = 7.8 Binding
Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)
ChEMBL 387 4 1 6 3.1 CC(C)N1Cc2c(Nc3ccc(Cl)cc3)nc(N3CCOCC3)nc2C1=O 10.1016/0960-894X(95)00502-K
CHEMBL98929 215056 0 None 36 2 Golden hamster 7.8 pKi = 7.8 Binding
Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)
ChEMBL 387 4 1 6 3.1 CC(C)N1Cc2c(Nc3ccc(Cl)cc3)nc(N3CCOCC3)nc2C1=O 10.1016/0960-894X(95)00502-K
10001490 168722 0 None - 1 Rat 7.8 pKi = 7.8 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 408 5 1 4 3.7 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccccn1 10.1021/jm00019a006
CHEMBL415518 168722 0 None - 1 Rat 7.8 pKi = 7.8 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 408 5 1 4 3.7 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccccn1 10.1021/jm00019a006
44577910 194990 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 606 12 3 6 4.2 O=C(/C=C/c1cccs1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1 10.1016/j.bmcl.2008.06.102
CHEMBL499153 194990 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 606 12 3 6 4.2 O=C(/C=C/c1cccs1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1 10.1016/j.bmcl.2008.06.102
2090 9543 25 None -38 4 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]NKA from human NK2R expressed in CHO cell membranes after 90 mins by scintillation counting analysisDisplacement of [125I]NKA from human NK2R expressed in CHO cell membranes after 90 mins by scintillation counting analysis
ChEMBL None None None None 10.1021/jm5017413
5311312 9543 25 None -38 4 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]NKA from human NK2R expressed in CHO cell membranes after 90 mins by scintillation counting analysisDisplacement of [125I]NKA from human NK2R expressed in CHO cell membranes after 90 mins by scintillation counting analysis
ChEMBL None None None None 10.1021/jm5017413
CHEMBL437797 9543 25 None -38 4 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]NKA from human NK2R expressed in CHO cell membranes after 90 mins by scintillation counting analysisDisplacement of [125I]NKA from human NK2R expressed in CHO cell membranes after 90 mins by scintillation counting analysis
ChEMBL None None None None 10.1021/jm5017413
11421866 143992 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 580 6 6 5 1.5 N[C@@H]1CC(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm040832y
CHEMBL375053 143992 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 580 6 6 5 1.5 N[C@@H]1CC(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm040832y
46236800 13555 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 616 11 2 6 5.4 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083862 13555 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 616 11 2 6 5.4 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
1752 52535 59 None -1 5 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 220 8 1 1 4.7 CCCCCCCCCc1ccc(O)cc1 nan
CHEMBL153062 52535 59 None -1 5 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 220 8 1 1 4.7 CCCCCCCCCc1ccc(O)cc1 nan
1548953 214458 27 None -7 17 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 405 9 0 2 6.6 CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1 nan
CHEMBL954 214458 27 None -7 17 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 405 9 0 2 6.6 CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1 nan
CHEMBL1201469 21279 0 None 1 4 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL None None None None nan
2406 107180 89 None -16 12 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 354 2 2 3 5.9 Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O nan
CHEMBL290106 107180 89 None -16 12 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 354 2 2 3 5.9 Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O nan
CHEMBL103939 215239 0 None - 1 Human 6.8 pKi = 6.8 Binding
The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2
ChEMBL None None None CC(C)CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(N)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(C)C)C(N)=O 10.1021/jm9807151
44281743 106415 0 None -2 2 Human 6.8 pKi = 6.8 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 690 11 1 5 9.1 CO/N=C(\C(C)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL284244 106415 0 None -2 2 Human 6.8 pKi = 6.8 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 690 11 1 5 9.1 CO/N=C(\C(C)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
10471895 124855 0 None - 1 Rat 5.8 pKi = 5.8 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 331 3 1 3 2.8 CN1CC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)OC1=O 10.1021/jm00019a006
CHEMBL340548 124855 0 None - 1 Rat 5.8 pKi = 5.8 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 331 3 1 3 2.8 CN1CC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)OC1=O 10.1021/jm00019a006
44301858 206866 0 None - 1 Rat 5.8 pKi = 5.8 Binding
Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon
ChEMBL 372 5 2 3 3.5 N#Cc1ccc2[nH]cc(CCN3CCC(NC(=O)c4ccccc4)CC3)c2c1 10.1016/S0960-894X(01)80541-2
CHEMBL59594 206866 0 None - 1 Rat 5.8 pKi = 5.8 Binding
Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon
ChEMBL 372 5 2 3 3.5 N#Cc1ccc2[nH]cc(CCN3CCC(NC(=O)c4ccccc4)CC3)c2c1 10.1016/S0960-894X(01)80541-2
CHEMBL583102 222560 6 None -5248 2 Human 5.8 pKi = 5.8 Binding
Binding affinity at human NK2 receptorBinding affinity at human NK2 receptor
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCSC)NC(=O)[C@@H](N)CC(=O)O)C(N)=O 10.1021/jm2017072
CHEMBL583102 222560 6 None -5248 2 Human 5.8 pKi = 5.8 Binding
Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCSC)NC(=O)[C@@H](N)CC(=O)O)C(N)=O 10.1021/jm900948q
11203189 71062 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 520 11 3 5 4.2 O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL181004 71062 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 520 11 3 5 4.2 O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
44337353 12199 0 None 9 2 Human 7.8 pKi = 7.8 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 635 7 2 5 4.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)c4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL107306 12199 0 None 9 2 Human 7.8 pKi = 7.8 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 635 7 2 5 4.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)c4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44363983 24938 0 None -2 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 769 15 2 7 7.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(CC(O)CO)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL126970 24938 0 None -2 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 769 15 2 7 7.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(CC(O)CO)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44363926 45843 0 None -3 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 669 11 1 6 7.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL146882 45843 0 None -3 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 669 11 1 6 7.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
10010039 46679 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 711 14 2 6 8.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CNC2(CO)CCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL147769 46679 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 711 14 2 6 8.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CNC2(CO)CCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44380457 64890 0 None -3 2 Human 7.8 pKi = 7.8 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 698 12 0 7 6.6 COC(=O)CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL167613 64890 0 None -3 2 Human 7.8 pKi = 7.8 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 698 12 0 7 6.6 COC(=O)CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
49863733 22104 0 None -2 4 Rat 6.8 pKi = 6.8 Binding
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 1477 21 11 14 6.8 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm100157m
CHEMBL1214026 22104 0 None -2 4 Rat 6.8 pKi = 6.8 Binding
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 1477 21 11 14 6.8 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm100157m
44391130 71709 0 None - 1 Human 5.8 pKi = 5.8 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 492 10 2 4 3.1 O=C(NCCCN1CCOCC1)[C@H](Cc1ccccc1)NC(=O)N1CCC(Cc2ccccc2)CC1 10.1016/j.bmcl.2004.11.045
CHEMBL182264 71709 0 None - 1 Human 5.8 pKi = 5.8 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 492 10 2 4 3.1 O=C(NCCCN1CCOCC1)[C@H](Cc1ccccc1)NC(=O)N1CCC(Cc2ccccc2)CC1 10.1016/j.bmcl.2004.11.045
44391136 72878 0 None - 1 Human 5.8 pKi = 5.8 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 487 11 2 5 3.1 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL183917 72878 0 None - 1 Human 5.8 pKi = 5.8 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 487 11 2 5 3.1 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
73354570 96185 0 None -13 2 Human 5.8 pKi = 5.8 Binding
Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)
ChEMBL 814 8 8 9 0.4 COc1ccc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)cc1CC=C(C)C 10.1021/jm00029a007
CHEMBL2370513 96185 0 None -13 2 Human 5.8 pKi = 5.8 Binding
Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)
ChEMBL 814 8 8 9 0.4 COc1ccc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)cc1CC=C(C)C 10.1021/jm00029a007
155558726 181587 0 None -3 4 Human 5.8 pKi = 5.8 Binding
Displacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter methodDisplacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter method
ChEMBL 835 11 0 13 6.7 CC(C)CCO[C@H]1[C@H]2CCN(CCc3ccc4ccccc4c3)CC[C@H]3O[C@H](Cn4cc(nn4)COC[C@@H](O2)[C@@H]2OC(C)(C)O[C@H]12)[C@@H]1OC(C)(C)O[C@@H]1[C@H]3OCCC(C)C 10.1016/j.ejmech.2019.04.064
CHEMBL4562303 181587 0 None -3 4 Human 5.8 pKi = 5.8 Binding
Displacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter methodDisplacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter method
ChEMBL 835 11 0 13 6.7 CC(C)CCO[C@H]1[C@H]2CCN(CCc3ccc4ccccc4c3)CC[C@H]3O[C@H](Cn4cc(nn4)COC[C@@H](O2)[C@@H]2OC(C)(C)O[C@H]12)[C@@H]1OC(C)(C)O[C@@H]1[C@H]3OCCC(C)C 10.1016/j.ejmech.2019.04.064
4189 213701 96 None -18 34 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL1559 213701 96 None -18 34 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL91 213701 96 None -18 34 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
5318 22348 49 None -1 13 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 396 6 0 3 6.5 Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
CHEMBL1200348 22348 49 None -1 13 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 396 6 0 3 6.5 Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
CHEMBL1221 22348 49 None -1 13 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 396 6 0 3 6.5 Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
44281957 106592 0 None -27 2 Human 6.8 pKi = 6.8 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 703 10 1 5 8.1 CO/N=C(\C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL285475 106592 0 None -27 2 Human 6.8 pKi = 6.8 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 703 10 1 5 8.1 CO/N=C(\C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44380290 106866 0 None -21 2 Human 7.8 pKi = 7.8 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 736 14 0 9 6.5 CN(C/C(=N\OCCCn1cnnn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL287369 106866 0 None -21 2 Human 7.8 pKi = 7.8 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 736 14 0 9 6.5 CN(C/C(=N\OCCCn1cnnn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
15887537 115823 0 None -3 3 Human 7.8 pKi = 7.8 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 700 7 1 4 7.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL321270 115823 0 None -3 3 Human 7.8 pKi = 7.8 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 700 7 1 4 7.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
44281303 107246 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 582 11 1 8 6.2 CO/N=C(\COCc1ccc2nonc2c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL290786 107246 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 582 11 1 8 6.2 CO/N=C(\COCc1ccc2nonc2c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44314946 211842 0 None -2 2 Human 6.8 pKi = 6.8 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 726 14 0 6 8.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N(C(C)C)C(C)C)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL77235 211842 0 None -2 2 Human 6.8 pKi = 6.8 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 726 14 0 6 8.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N(C(C)C)C(C)C)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
5362440 16793 63 None - 1 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 613 11 4 7 2.9 CC(C)(C)NC(=O)[C@@H]1CN(Cc2cccnc2)CCN1C[C@@H](O)C[C@@H](Cc1ccccc1)C(=O)N[C@H]1c2ccccc2C[C@H]1O nan
CHEMBL115 16793 63 None - 1 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 613 11 4 7 2.9 CC(C)(C)NC(=O)[C@@H]1CN(Cc2cccnc2)CCN1C[C@@H](O)C[C@@H](Cc1ccccc1)C(=O)N[C@H]1c2ccccc2C[C@H]1O nan
44266422 11214 0 None -79 2 Human 6.8 pKi = 6.8 Binding
Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 423 7 1 3 5.8 CC[C@@H](NC(=O)c1c(CN(C)C)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm980633c
CHEMBL10162 11214 0 None -79 2 Human 6.8 pKi = 6.8 Binding
Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 423 7 1 3 5.8 CC[C@@H](NC(=O)c1c(CN(C)C)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm980633c
10812218 178851 0 None -79 3 Human 6.8 pKi = 6.8 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 423 7 1 3 5.8 CC[C@H](NC(=O)c1c(CN(C)C)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm000501v
CHEMBL44722 178851 0 None -79 3 Human 6.8 pKi = 6.8 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 423 7 1 3 5.8 CC[C@H](NC(=O)c1c(CN(C)C)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm000501v
44337414 15987 0 None -5 2 Human 6.8 pKi = 6.8 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 889 13 2 7 9.1 O=C(CN(NC1CCN(Cc2ccccc2)CC1)NC1CCN(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00645-5
CHEMBL110507 15987 0 None -5 2 Human 6.8 pKi = 6.8 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 889 13 2 7 9.1 O=C(CN(NC1CCN(Cc2ccccc2)CC1)NC1CCN(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00645-5
44329163 118226 0 None -2 2 Human 4.8 pKi = 4.8 Binding
Inhibition constant for displacement of [3H]NKA from the cloned human NK2 receptorInhibition constant for displacement of [3H]NKA from the cloned human NK2 receptor
ChEMBL 344 3 2 6 2.8 Cc1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
CHEMBL327531 118226 0 None -2 2 Human 4.8 pKi = 4.8 Binding
Inhibition constant for displacement of [3H]NKA from the cloned human NK2 receptorInhibition constant for displacement of [3H]NKA from the cloned human NK2 receptor
ChEMBL 344 3 2 6 2.8 Cc1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
22901328 214447 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 420 4 3 6 4.2 CC(C)c1nc2[nH]c(N3CCC(O)CC3)nc(Nc3ccc(C(F)(F)F)cc3)c-2n1 10.1016/0960-894X(95)00502-K
CHEMBL95347 214447 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 420 4 3 6 4.2 CC(C)c1nc2[nH]c(N3CCC(O)CC3)nc(Nc3ccc(C(F)(F)F)cc3)c-2n1 10.1016/0960-894X(95)00502-K
44281713 106439 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 600 13 1 7 6.7 CO/N=C(\COCc1cc(OC)cc(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL284396 106439 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 600 13 1 7 6.7 CO/N=C(\COCc1cc(OC)cc(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
9849950 108147 0 None 64 2 Human 7.7 pKi = 7.7 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 458 8 1 4 5.3 CCC(CC)NC(=O)c1c(CN2CCN(C(C)C)CC2)c(-c2ccccc2)nc2ccccc12 10.1021/jm000501v
CHEMBL297086 108147 0 None 64 2 Human 7.7 pKi = 7.7 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 458 8 1 4 5.3 CCC(CC)NC(=O)c1c(CN2CCN(C(C)C)CC2)c(-c2ccccc2)nc2ccccc12 10.1021/jm000501v
10189341 16891 0 None -10 2 Human 6.7 pKi = 6.7 Binding
In vitro binding affinity towards Human Tachykinin receptor 2In vitro binding affinity towards Human Tachykinin receptor 2
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
CHEMBL115633 16891 0 None -10 2 Human 6.7 pKi = 6.7 Binding
In vitro binding affinity towards Human Tachykinin receptor 2In vitro binding affinity towards Human Tachykinin receptor 2
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
141952732 127243 0 None -1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 734 13 3 7 7.8 N/C(CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)=N/O 10.1016/s0960-894x(02)00027-6
44380527 127243 0 None -1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 734 13 3 7 7.8 N/C(CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)=N/O 10.1016/s0960-894x(02)00027-6
CHEMBL354091 127243 0 None -1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 734 13 3 7 7.8 N/C(CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)=N/O 10.1016/s0960-894x(02)00027-6
44380095 127634 0 None -1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 687 11 1 6 8.6 N#CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL355868 127634 0 None -1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 687 11 1 6 8.6 N#CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
10390570 23316 0 None - 1 Rat 7.7 pKi = 7.7 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 483 6 1 3 5.9 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1C(c1ccccc1)c1ccccc1 10.1021/jm00019a006
CHEMBL123731 23316 0 None - 1 Rat 7.7 pKi = 7.7 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 483 6 1 3 5.9 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1C(c1ccccc1)c1ccccc1 10.1021/jm00019a006
10093650 23575 0 None - 1 Rat 7.7 pKi = 7.7 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 421 5 1 3 4.9 CC(c1ccccc1)N1CC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)OC1=O 10.1021/jm00019a006
CHEMBL124624 23575 0 None - 1 Rat 7.7 pKi = 7.7 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 421 5 1 3 4.9 CC(c1ccccc1)N1CC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)OC1=O 10.1021/jm00019a006
10344101 123619 0 None - 1 Rat 7.7 pKi = 7.7 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 457 5 1 3 5.5 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccc2ccccc2c1 10.1021/jm00019a006
CHEMBL338030 123619 0 None - 1 Rat 7.7 pKi = 7.7 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 457 5 1 3 5.5 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccc2ccccc2c1 10.1021/jm00019a006
11802167 85563 0 None - 1 Human 7.7 pKi = 7.7 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 633 6 5 4 3.6 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(C(F)(F)F)cc2)CN1 10.1021/jm0010217
CHEMBL2112675 85563 0 None - 1 Human 7.7 pKi = 7.7 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 633 6 5 4 3.6 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(C(F)(F)F)cc2)CN1 10.1021/jm0010217
44434171 96101 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 614 15 4 7 3.0 NCCOCCOCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)Cc2ccccc2C1 10.1016/j.bmcl.2007.06.053
CHEMBL236890 96101 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 614 15 4 7 3.0 NCCOCCOCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)Cc2ccccc2C1 10.1016/j.bmcl.2007.06.053
44434184 96287 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 560 11 3 5 4.7 O=C(NC1(C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCCN2CCCC2)CCCCC1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
CHEMBL237303 96287 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 560 11 3 5 4.7 O=C(NC1(C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCCN2CCCC2)CCCCC1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
44577885 195398 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 618 13 3 6 4.1 CCOc1cccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)c1 10.1016/j.bmcl.2008.06.102
CHEMBL502914 195398 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 618 13 3 6 4.1 CCOc1cccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)c1 10.1016/j.bmcl.2008.06.102
54583959 67443 0 None -38 4 Human 4.7 pKi = 4.7 Binding
Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor
ChEMBL 410 5 1 4 3.7 COc1ccccc1CN1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)n[nH]2)CC1 10.1016/j.bmcl.2011.02.033
CHEMBL1760339 67443 0 None -38 4 Human 4.7 pKi = 4.7 Binding
Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor
ChEMBL 410 5 1 4 3.7 COc1ccccc1CN1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)n[nH]2)CC1 10.1016/j.bmcl.2011.02.033
11790 106263 98 None -2 4 Human 5.7 pKi = 5.7 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 272 1 0 2 4.6 O=c1cc(-c2ccccc2)oc2c1ccc1ccccc12 nan
CHEMBL283196 106263 98 None -2 4 Human 5.7 pKi = 5.7 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 272 1 0 2 4.6 O=c1cc(-c2ccccc2)oc2c1ccc1ccccc12 nan
118724123 123190 0 None - 1 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
ChEMBL 954 29 11 16 -1.6 CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)C(CCNc1ccc([N+](=O)[O-])c2nonc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(C)=O)C(N)=O 10.1021/jm401823z
CHEMBL3360202 123190 0 None - 1 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
ChEMBL 954 29 11 16 -1.6 CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)C(CCNc1ccc([N+](=O)[O-])c2nonc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(C)=O)C(N)=O 10.1021/jm401823z
44363948 43151 0 None -5 2 Human 6.7 pKi = 6.7 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 653 11 0 5 8.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL144668 43151 0 None -5 2 Human 6.7 pKi = 6.7 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 653 11 0 5 8.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44380795 212911 0 None -7 2 Human 6.7 pKi = 6.7 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 734 13 1 7 8.3 COC(=O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL85980 212911 0 None -7 2 Human 6.7 pKi = 6.7 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 734 13 1 7 8.3 COC(=O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
10454135 24744 0 None - 1 Rat 6.7 pKi = 6.7 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 408 5 1 4 3.7 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1cccnc1 10.1021/jm00019a006
CHEMBL126158 24744 0 None - 1 Rat 6.7 pKi = 6.7 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 408 5 1 4 3.7 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1cccnc1 10.1021/jm00019a006
44380415 127093 0 None -2 2 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 683 12 1 6 5.9 CN(C/C(=N\OCC(N)=O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL352813 127093 0 None -2 2 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 683 12 1 6 5.9 CN(C/C(=N\OCC(N)=O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44281685 106807 0 None 5 2 Human 8.7 pKi = 8.7 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 587 10 1 6 6.6 CO/N=C(\CN(C)C(=O)c1ccc(C)s1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL286901 106807 0 None 5 2 Human 8.7 pKi = 8.7 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 587 10 1 6 6.6 CO/N=C(\CN(C)C(=O)c1ccc(C)s1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281977 116171 0 None -1 2 Human 8.7 pKi = 8.7 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 595 10 1 5 6.8 CO/N=C(\CN(C)C(=O)c1cc(C)cc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32197 116171 0 None -1 2 Human 8.7 pKi = 8.7 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 595 10 1 5 6.8 CO/N=C(\CN(C)C(=O)c1cc(C)cc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281976 117351 0 None 2 2 Human 8.7 pKi = 8.7 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 627 12 1 7 6.2 CO/N=C(\CN(C)C(=O)c1cc(OC)cc(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32537 117351 0 None 2 2 Human 8.7 pKi = 8.7 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 627 12 1 7 6.2 CO/N=C(\CN(C)C(=O)c1cc(OC)cc(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
10394882 120589 0 None -1 2 Human 8.7 pKi = 8.7 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 689 10 2 5 7.9 CO/N=C(\CNC(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33249 120589 0 None -1 2 Human 8.7 pKi = 8.7 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 689 10 2 5 7.9 CO/N=C(\CNC(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
137633652 163375 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]NKA from human recombinant tachykinin NK2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [125I]NKA from human recombinant tachykinin NK2 receptor expressed in CHO cells after 60 mins by scintillation counting
ChEMBL 749 24 10 10 -1.5 CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)O 10.1021/acs.jmedchem.6b01422
CHEMBL4068783 163375 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]NKA from human recombinant tachykinin NK2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [125I]NKA from human recombinant tachykinin NK2 receptor expressed in CHO cells after 60 mins by scintillation counting
ChEMBL 749 24 10 10 -1.5 CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)O 10.1021/acs.jmedchem.6b01422
9918520 109528 0 None -2 2 Guinea pig 8.7 pKi = 8.7 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL305055 109528 0 None -2 2 Guinea pig 8.7 pKi = 8.7 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
9896563 110557 0 None -5 2 Guinea pig 8.7 pKi = 8.7 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CCC(/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
CHEMBL308891 110557 0 None -5 2 Guinea pig 8.7 pKi = 8.7 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CCC(/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
44307953 175973 0 None -35 2 Guinea pig 8.7 pKi = 8.7 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 784 12 1 7 6.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)[S+]3CCNCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL440679 175973 0 None -35 2 Guinea pig 8.7 pKi = 8.7 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 784 12 1 7 6.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)[S+]3CCNCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL540651 175973 0 None -35 2 Guinea pig 8.7 pKi = 8.7 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 784 12 1 7 6.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)[S+]3CCNCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
9939307 210265 0 None -6 4 Guinea pig 8.7 pKi = 8.7 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL66106 210265 0 None -6 4 Guinea pig 8.7 pKi = 8.7 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
52918297 65263 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins
ChEMBL 611 12 2 6 4.8 O=C(NC1(C(=O)N[C@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1)c1cc2ccccc2cn1 10.1016/j.bmcl.2011.01.074
CHEMBL1683152 65263 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins
ChEMBL 611 12 2 6 4.8 O=C(NC1(C(=O)N[C@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1)c1cc2ccccc2cn1 10.1016/j.bmcl.2011.01.074
23626111 92921 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 645 12 3 7 4.0 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCC(N3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
CHEMBL231173 92921 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 645 12 3 7 4.0 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCC(N3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
22405735 85195 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 489 9 1 4 6.2 CC/C(=N/O)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
CHEMBL2111522 85195 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 489 9 1 4 6.2 CC/C(=N/O)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
23625785 159449 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 556 11 3 5 3.4 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1ccc2ccccc2c1 10.1021/jm070289w
CHEMBL397264 159449 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 556 11 3 5 3.4 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1ccc2ccccc2c1 10.1021/jm070289w
10187380 159448 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 545 11 4 5 2.8 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2ccccc2[nH]1 10.1021/jm070289w
CHEMBL397263 159448 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 545 11 4 5 2.8 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2ccccc2[nH]1 10.1021/jm070289w
10209751 92780 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 559 11 3 6 2.8 Cn1c(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)CCCC2)cc2ccccc21 10.1021/jm070289w
CHEMBL230426 92780 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 559 11 3 6 2.8 Cn1c(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)CCCC2)cc2ccccc21 10.1021/jm070289w
23653789 10359 24 None 1 2 Human 8.6 pKi = 8.6 Binding
Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm8016514
9280 10359 24 None 1 2 Human 8.6 pKi = 8.6 Binding
Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm8016514
CHEMBL447955 10359 24 None 1 2 Human 8.6 pKi = 8.6 Binding
Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm8016514
DB12973 10359 24 None 1 2 Human 8.6 pKi = 8.6 Binding
Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm8016514
9825316 186287 0 None 1 3 Human 8.6 pKi = 8.6 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 456 6 2 4 5.0 C[C@H](NC(=O)c1c(CN2CCNCC2)c(-c2ccccc2)nc2ccccc12)C1CCCCC1 10.1021/jm000501v
CHEMBL47412 186287 0 None 1 3 Human 8.6 pKi = 8.6 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 456 6 2 4 5.0 C[C@H](NC(=O)c1c(CN2CCNCC2)c(-c2ccccc2)nc2ccccc12)C1CCCCC1 10.1021/jm000501v
44315267 112282 0 None 40 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 701 11 1 7 8.5 CO/N=C(\CN(C(=O)c1cc(Cl)cc(Cl)c1)C1CC1)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL312141 112282 0 None 40 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 701 11 1 7 8.5 CO/N=C(\CN(C(=O)c1cc(Cl)cc(Cl)c1)C1CC1)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44315209 211690 0 None -1 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 728 12 0 8 7.9 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC#N)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL76093 211690 0 None -1 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 728 12 0 8 7.9 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC#N)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
9979586 23581 0 None - 1 Rat 8.6 pKi = 8.6 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 421 4 1 4 4.0 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1C(=O)c1ccccc1 10.1021/jm00019a006
CHEMBL124648 23581 0 None - 1 Rat 8.6 pKi = 8.6 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 421 4 1 4 4.0 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1C(=O)c1ccccc1 10.1021/jm00019a006
44353064 164136 0 None - 1 Human 8.6 pKi = 8.6 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 960 12 13 13 -3.9 CC(=O)N[C@@H]1[C@@H](CO)[C@H](O)[C@@H](CO)O[C@H]1NC(=O)C[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CNC(=O)C[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2 10.1021/jm0010217
CHEMBL407782 164136 0 None - 1 Human 8.6 pKi = 8.6 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 960 12 13 13 -3.9 CC(=O)N[C@@H]1[C@@H](CO)[C@H](O)[C@@H](CO)O[C@H]1NC(=O)C[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CNC(=O)C[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2 10.1021/jm0010217
44434205 96177 0 None 50 2 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 623 11 3 6 3.7 CN1CCN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)Cc3ccccc3C2)CC1 10.1016/j.bmcl.2007.06.053
CHEMBL237048 96177 0 None 50 2 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 623 11 3 6 3.7 CN1CCN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)Cc3ccccc3C2)CC1 10.1016/j.bmcl.2007.06.053
44374598 126269 0 None 1 2 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 811 10 10 10 -1.2 CC(=O)NC1C(NC(=O)C2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)OC(CO)C(O)C1O 10.1016/s0960-894x(01)00841-1
CHEMBL345402 126269 0 None 1 2 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 811 10 10 10 -1.2 CC(=O)NC1C(NC(=O)C2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)OC(CO)C(O)C1O 10.1016/s0960-894x(01)00841-1
9887650 23423 0 None -1 5 Guinea pig 8.6 pKi = 8.6 Binding
The compound was tested for binding affinity against Tachykinin receptor 2 from guinea pig tracheaThe compound was tested for binding affinity against Tachykinin receptor 2 from guinea pig trachea
ChEMBL 407 5 1 3 4.3 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccccc1 10.1021/jm00019a006
CHEMBL124208 23423 0 None -1 5 Guinea pig 8.6 pKi = 8.6 Binding
The compound was tested for binding affinity against Tachykinin receptor 2 from guinea pig tracheaThe compound was tested for binding affinity against Tachykinin receptor 2 from guinea pig trachea
ChEMBL 407 5 1 3 4.3 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccccc1 10.1021/jm00019a006
44315572 109758 0 None -1 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 689 11 1 7 8.3 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL306624 109758 0 None -1 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 689 11 1 7 8.3 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
9918479 64386 0 None 1 2 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 748 14 1 7 6.7 CN(C/C(=N\OCCCS(=O)(=O)O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL166827 64386 0 None 1 2 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 748 14 1 7 6.7 CN(C/C(=N\OCCCS(=O)(=O)O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
71461711 86417 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 489 9 1 4 6.2 CCC(=NO)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
CHEMBL2115072 86417 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 489 9 1 4 6.2 CCC(=NO)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
44315231 112176 0 None -1 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 780 13 0 8 8.8 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(Cc3ccccn3)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL311712 112176 0 None -1 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 780 13 0 8 8.8 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(Cc3ccccn3)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
10167532 99945 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 596 11 3 6 4.2 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2c(Cl)cccc2s1 10.1021/jm070289w
CHEMBL244363 99945 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 596 11 3 6 4.2 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2c(Cl)cccc2s1 10.1021/jm070289w
18393120 12032 0 None 10 2 Human 7.7 pKi = 7.7 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 502 5 2 4 4.0 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCNCC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL106404 12032 0 None 10 2 Human 7.7 pKi = 7.7 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 502 5 2 4 4.0 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCNCC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44281415 106471 0 None - 1 Human 7.7 pKi = 7.7 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 702 12 1 5 9.2 CO/N=C(\COC/C=C/c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL284597 106471 0 None - 1 Human 7.7 pKi = 7.7 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 702 12 1 5 9.2 CO/N=C(\COC/C=C/c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281680 125369 0 None - 1 Human 7.7 pKi = 7.7 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 659 11 1 6 8.2 CO/N=C(\COCc1ccc2ccc(C(F)(F)F)nc2c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL34167 125369 0 None - 1 Human 7.7 pKi = 7.7 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 659 11 1 6 8.2 CO/N=C(\COCc1ccc2ccc(C(F)(F)F)nc2c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44363909 42674 0 None 5 2 Human 7.7 pKi = 7.7 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 739 13 0 7 8.5 CCOC(=O)C1CCCN(C2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1 10.1016/s0960-894x(00)00702-2
CHEMBL144223 42674 0 None 5 2 Human 7.7 pKi = 7.7 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 739 13 0 7 8.5 CCOC(=O)C1CCCN(C2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1 10.1016/s0960-894x(00)00702-2
23625321 99083 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 536 11 3 6 3.0 CC(C)(NC(=O)c1cc2ccccc2s1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1021/jm070289w
CHEMBL242847 99083 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 536 11 3 6 3.0 CC(C)(NC(=O)c1cc2ccccc2s1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1021/jm070289w
44390529 70958 0 None - 1 Human 6.7 pKi = 6.7 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 520 11 3 5 4.2 O=C(Nc1ccc(Oc2cccc(F)c2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL180877 70958 0 None - 1 Human 6.7 pKi = 6.7 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 520 11 3 5 4.2 O=C(Nc1ccc(Oc2cccc(F)c2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
44390606 71071 0 None - 1 Human 6.7 pKi = 6.7 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 530 12 3 5 4.6 CCc1ccc(Oc2ccc(NC(=O)N[C@@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc1 10.1016/j.bmcl.2004.11.045
CHEMBL181050 71071 0 None - 1 Human 6.7 pKi = 6.7 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 530 12 3 5 4.6 CCc1ccc(Oc2ccc(NC(=O)N[C@@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc1 10.1016/j.bmcl.2004.11.045
44390998 72363 0 None - 1 Human 6.7 pKi = 6.7 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 502 11 3 5 4.1 O=C(Nc1cccc(Oc2ccccc2)c1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL183232 72363 0 None - 1 Human 6.7 pKi = 6.7 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 502 11 3 5 4.1 O=C(Nc1cccc(Oc2ccccc2)c1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
44390535 129595 0 None - 1 Human 6.7 pKi = 6.7 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 576 14 3 7 3.9 COc1cc(COc2ccc(NC(=O)N[C@@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc(OC)c1 10.1016/j.bmcl.2004.11.045
CHEMBL360546 129595 0 None - 1 Human 6.7 pKi = 6.7 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 576 14 3 7 3.9 COc1cc(COc2ccc(NC(=O)N[C@@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc(OC)c1 10.1016/j.bmcl.2004.11.045
44390588 130484 0 None - 1 Human 6.7 pKi = 6.7 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 544 12 3 5 5.2 CC(C)c1ccc(Oc2ccc(NC(=O)N[C@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc1 10.1016/j.bmcl.2004.11.045
CHEMBL362201 130484 0 None - 1 Human 6.7 pKi = 6.7 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 544 12 3 5 5.2 CC(C)c1ccc(Oc2ccc(NC(=O)N[C@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc1 10.1016/j.bmcl.2004.11.045
44314597 111128 0 None -3 2 Human 6.7 pKi = 6.7 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 599 10 0 5 7.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(C)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL310019 111128 0 None -3 2 Human 6.7 pKi = 6.7 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 599 10 0 5 7.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(C)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44391006 70850 0 None - 1 Human 5.7 pKi = 5.7 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 485 11 2 4 3.4 O=C(N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1)C(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2004.11.045
CHEMBL180749 70850 0 None - 1 Human 5.7 pKi = 5.7 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 485 11 2 4 3.4 O=C(N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1)C(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2004.11.045
44390987 71218 0 None - 1 Human 5.7 pKi = 5.7 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 471 10 2 4 3.5 O=C(N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1)c1cccc(-c2ccccc2)c1 10.1016/j.bmcl.2004.11.045
CHEMBL181329 71218 0 None - 1 Human 5.7 pKi = 5.7 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 471 10 2 4 3.5 O=C(N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1)c1cccc(-c2ccccc2)c1 10.1016/j.bmcl.2004.11.045
44390994 71610 0 None - 1 Human 5.7 pKi = 5.7 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 438 10 2 4 2.3 CN(Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL181998 71610 0 None - 1 Human 5.7 pKi = 5.7 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 438 10 2 4 2.3 CN(Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
44391145 129209 0 None - 1 Human 5.7 pKi = 5.7 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 492 10 2 4 3.1 O=C(NCCCN1CCOCC1)[C@@H](Cc1ccccc1)NC(=O)N1CCC(Cc2ccccc2)CC1 10.1016/j.bmcl.2004.11.045
CHEMBL360085 129209 0 None - 1 Human 5.7 pKi = 5.7 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 492 10 2 4 3.1 O=C(NCCCN1CCOCC1)[C@@H](Cc1ccccc1)NC(=O)N1CCC(Cc2ccccc2)CC1 10.1016/j.bmcl.2004.11.045
3198 212292 76 None -21 34 Human 5.7 pKi = 5.7 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
CHEMBL1201049 212292 76 None -21 34 Human 5.7 pKi = 5.7 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
CHEMBL808 212292 76 None -21 34 Human 5.7 pKi = 5.7 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
44329015 214760 0 None - 1 Golden hamster 4.7 pKi = 4.7 Binding
Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)
ChEMBL 384 4 2 6 3.6 O=C(O)c1ccc2c(Nc3ccc(Cl)cc3)nc(N3CCOCC3)nc2c1 10.1016/0960-894X(95)00502-K
CHEMBL97204 214760 0 None - 1 Golden hamster 4.7 pKi = 4.7 Binding
Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)
ChEMBL 384 4 2 6 3.6 O=C(O)c1ccc2c(Nc3ccc(Cl)cc3)nc(N3CCOCC3)nc2c1 10.1016/0960-894X(95)00502-K
138106885 173690 75 None -1 4 Human 5.7 pKi = 5.7 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 853 10 4 14 3.7 CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C nan
36314 173690 75 None -1 4 Human 5.7 pKi = 5.7 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 853 10 4 14 3.7 CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C nan
CHEMBL428647 173690 75 None -1 4 Human 5.7 pKi = 5.7 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 853 10 4 14 3.7 CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C nan
441243 16608 58 None -19 8 Human 5.7 pKi = 5.7 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 670 12 5 7 3.1 CC(C)(C)NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2CN1C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)c1ccc2ccccc2n1 nan
CHEMBL114 16608 58 None -19 8 Human 5.7 pKi = 5.7 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 670 12 5 7 3.1 CC(C)(C)NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2CN1C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)c1ccc2ccccc2n1 nan
44314533 112456 0 None -2 2 Human 6.7 pKi = 6.7 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 710 12 0 6 7.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL312539 112456 0 None -2 2 Human 6.7 pKi = 6.7 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 710 12 0 6 7.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44314482 110586 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL309087 110586 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44281516 106658 0 None 3 2 Human 7.7 pKi = 7.7 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 608 11 1 5 8.0 CO/N=C(\COCc1ccc(F)c2ccccc12)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL285929 106658 0 None 3 2 Human 7.7 pKi = 7.7 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 608 11 1 5 8.0 CO/N=C(\COCc1ccc(F)c2ccccc12)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281333 119500 0 None - 1 Human 7.7 pKi = 7.7 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 611 11 1 7 7.6 CO/N=C(\COCc1ccc2sc(C)nc2c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33046 119500 0 None - 1 Human 7.7 pKi = 7.7 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 611 11 1 7 7.6 CO/N=C(\COCc1ccc2sc(C)nc2c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44314482 110586 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL309087 110586 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
10078301 126010 0 None -2 2 Human 7.7 pKi = 7.7 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 681 12 0 5 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL343447 126010 0 None -2 2 Human 7.7 pKi = 7.7 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 681 12 0 5 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44314482 110586 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL309087 110586 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
44314482 110586 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL309087 110586 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
10394952 111526 0 None -1 2 Human 7.7 pKi = 7.7 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 696 12 0 6 7.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL310703 111526 0 None -1 2 Human 7.7 pKi = 7.7 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 696 12 0 6 7.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
10417108 106876 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Tested for binding affinity of compound against Tachykinin receptor 2Tested for binding affinity of compound against Tachykinin receptor 2
ChEMBL 676 11 1 5 8.7 CO/N=C(/COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL287454 106876 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Tested for binding affinity of compound against Tachykinin receptor 2Tested for binding affinity of compound against Tachykinin receptor 2
ChEMBL 676 11 1 5 8.7 CO/N=C(/COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
10250427 114211 0 None - 1 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 400 4 3 6 4.2 CC(C)c1nc2[nH]c(N3CCC(C)(O)CC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
CHEMBL318198 114211 0 None - 1 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 400 4 3 6 4.2 CC(C)c1nc2[nH]c(N3CCC(C)(O)CC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
44266599 11418 0 None -97 2 Human 6.7 pKi = 6.7 Binding
Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 440 8 2 4 5.2 CC[C@@H](NC(=O)c1c(OCC(=O)O)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm980633c
CHEMBL10303 11418 0 None -97 2 Human 6.7 pKi = 6.7 Binding
Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 440 8 2 4 5.2 CC[C@@H](NC(=O)c1c(OCC(=O)O)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm980633c
44380277 66019 0 None -2 2 Human 6.7 pKi = 6.7 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 702 13 1 5 9.3 C=CCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL170325 66019 0 None -2 2 Human 6.7 pKi = 6.7 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 702 13 1 5 9.3 C=CCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44314548 109686 0 None -3 2 Human 6.7 pKi = 6.7 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 663 11 0 7 7.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(c2ncccn2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL306052 109686 0 None -3 2 Human 6.7 pKi = 6.7 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 663 11 0 7 7.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(c2ncccn2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44337201 115389 0 None -245 3 Human 6.7 pKi = 6.7 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)[C@@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL320548 115389 0 None -245 3 Human 6.7 pKi = 6.7 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)[C@@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44337308 12218 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 600 7 1 4 5.6 O=C(c1cc(F)cc(F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL107407 12218 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 600 7 1 4 5.6 O=C(c1cc(F)cc(F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
44282003 106887 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 689 11 1 5 8.6 CO/N=C(\CN(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL287523 106887 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 689 11 1 5 8.6 CO/N=C(\CN(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
9874473 48582 0 None -16 3 Human 7.7 pKi = 7.7 Binding
In vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligandIn vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
CHEMBL149326 48582 0 None -16 3 Human 7.7 pKi = 7.7 Binding
In vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligandIn vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
10600223 186247 0 None -4 3 Human 7.7 pKi = 7.7 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 464 7 2 4 5.2 CC[C@H](NC(=O)c1c(CN2CCNCC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm000501v
CHEMBL47408 186247 0 None -4 3 Human 7.7 pKi = 7.7 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 464 7 2 4 5.2 CC[C@H](NC(=O)c1c(CN2CCNCC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm000501v
44329340 215199 0 None - 1 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 462 5 3 6 5.3 CC(C)c1nc2[nH]c(N3CCC(O)(c4ccccc4)CC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
CHEMBL99823 215199 0 None - 1 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 462 5 3 6 5.3 CC(C)c1nc2[nH]c(N3CCC(O)(c4ccccc4)CC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
657255 205863 34 None -17 15 Human 5.6 pKi = 5.6 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 337 12 2 3 5.6 CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1 nan
CHEMBL588119 205863 34 None -17 15 Human 5.6 pKi = 5.6 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 337 12 2 3 5.6 CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1 nan
44380092 127139 0 None -12 2 Human 7.6 pKi = 7.6 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 698 12 1 6 7.2 CN(C/C(=N\OCC(C)(C)O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL353162 127139 0 None -12 2 Human 7.6 pKi = 7.6 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 698 12 1 6 7.2 CN(C/C(=N\OCC(C)(C)O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44363436 42489 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 711 12 0 5 9.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2=S)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL144057 42489 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 711 12 0 5 9.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2=S)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44363949 127720 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 683 11 0 5 8.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC2=S)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL356105 127720 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 683 11 0 5 8.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC2=S)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
9874473 48582 0 None -16 3 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligandIn vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
CHEMBL149326 48582 0 None -16 3 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligandIn vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
44383761 136595 0 None - 1 Rat 7.6 pKi = 7.6 Binding
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 565 10 1 3 6.4 CC(=O)NCC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/S0960-894X(00)80694-0
CHEMBL367542 136595 0 None - 1 Rat 7.6 pKi = 7.6 Binding
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 565 10 1 3 6.4 CC(=O)NCC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/S0960-894X(00)80694-0
86274490 166665 0 None -1148 3 Human 4.6 pKi = 4.6 Binding
Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 392 2 0 7 3.1 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(F)c2)[C@@H]3C)n1 nan
CHEMBL4106866 166665 0 None -1148 3 Human 4.6 pKi = 4.6 Binding
Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 392 2 0 7 3.1 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(F)c2)[C@@H]3C)n1 nan
10044833 114224 0 None -43 2 Human 5.6 pKi = 5.6 Binding
Inhibition constant for displacement of [3H]NKA from the cloned human NK2 receptorInhibition constant for displacement of [3H]NKA from the cloned human NK2 receptor
ChEMBL 372 5 2 6 3.5 CCCc1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
CHEMBL318254 114224 0 None -43 2 Human 5.6 pKi = 5.6 Binding
Inhibition constant for displacement of [3H]NKA from the cloned human NK2 receptorInhibition constant for displacement of [3H]NKA from the cloned human NK2 receptor
ChEMBL 372 5 2 6 3.5 CCCc1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
44380313 64865 0 None -15 2 Human 6.6 pKi = 6.6 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 647 10 1 4 8.3 O=C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL167409 64865 0 None -15 2 Human 6.6 pKi = 6.6 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 647 10 1 4 8.3 O=C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
1760285 215169 3 None -13 2 Human 6.6 pKi = 6.6 Binding
Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)
ChEMBL 366 5 1 2 5.8 CC[C@H](NC(=O)c1cc(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm9602423
CHEMBL9960 215169 3 None -13 2 Human 6.6 pKi = 6.6 Binding
Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)
ChEMBL 366 5 1 2 5.8 CC[C@H](NC(=O)c1cc(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm9602423
1760287 11068 2 None -2 2 Human 6.6 pKi = 6.6 Binding
Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 366 5 1 2 5.8 CC[C@@H](NC(=O)c1cc(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm980633c
CHEMBL10079 11068 2 None -2 2 Human 6.6 pKi = 6.6 Binding
Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 366 5 1 2 5.8 CC[C@@H](NC(=O)c1cc(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm980633c
44380764 127506 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 689 11 1 5 8.6 CN(C)/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL354822 127506 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 689 11 1 5 8.6 CN(C)/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
10395141 211604 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 726 13 1 7 6.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CC[C@@H](CO)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL75367 211604 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 726 13 1 7 6.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CC[C@@H](CO)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44302769 168456 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligandBinding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligand
ChEMBL 1350 26 11 15 6.5 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CCCC(N)/C(S)=N/c1ccc2c(c1)C(=O)OC21c2ccc(O)cc2Oc2cc(O)ccc21)NC(=O)c1ccccc1)C(N)=O 10.1021/jm00039a012
CHEMBL413205 168456 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligandBinding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligand
ChEMBL 1350 26 11 15 6.5 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CCCC(N)/C(S)=N/c1ccc2c(c1)C(=O)OC21c2ccc(O)cc2Oc2cc(O)ccc21)NC(=O)c1ccccc1)C(N)=O 10.1021/jm00039a012
23625324 99139 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 576 11 2 6 3.9 CN(C(=O)c1cc2ccccc2s1)C1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1 10.1021/jm070289w
CHEMBL243071 99139 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 576 11 2 6 3.9 CN(C(=O)c1cc2ccccc2s1)C1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1 10.1021/jm070289w
44305818 21567 0 None -630 4 Human 5.6 pKi = 5.6 Binding
Binding affinity for NK-2 receptor was determined in a radioligand binding assay using chinese hamster ovary cells.Binding affinity for NK-2 receptor was determined in a radioligand binding assay using chinese hamster ovary cells.
ChEMBL 698 13 3 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL1206764 21567 0 None -630 4 Human 5.6 pKi = 5.6 Binding
Binding affinity for NK-2 receptor was determined in a radioligand binding assay using chinese hamster ovary cells.Binding affinity for NK-2 receptor was determined in a radioligand binding assay using chinese hamster ovary cells.
ChEMBL 698 13 3 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL305119 21567 0 None -630 4 Human 5.6 pKi = 5.6 Binding
Binding affinity for NK-2 receptor was determined in a radioligand binding assay using chinese hamster ovary cells.Binding affinity for NK-2 receptor was determined in a radioligand binding assay using chinese hamster ovary cells.
ChEMBL 698 13 3 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
73350089 96183 0 None -19 2 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)
ChEMBL 816 9 8 9 0.5 CCC(C)Cc1cc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)ccc1OC 10.1021/jm00029a007
CHEMBL2370510 96183 0 None -19 2 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)
ChEMBL 816 9 8 9 0.5 CCC(C)Cc1cc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)ccc1OC 10.1021/jm00029a007
44380289 127033 0 None -14 2 Human 7.6 pKi = 7.6 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 734 14 0 7 7.7 CN(C/C(=N\OCCCn1cccn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL352364 127033 0 None -14 2 Human 7.6 pKi = 7.6 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 734 14 0 7 7.7 CN(C/C(=N\OCCCn1cccn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44281784 120270 0 None 6 2 Human 7.6 pKi = 7.6 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 690 10 1 6 8.3 CO/N=C(\COC(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33198 120270 0 None 6 2 Human 7.6 pKi = 7.6 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 690 10 1 6 8.3 CO/N=C(\COC(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44434189 175605 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 576 11 3 6 3.9 O=C(NC1(C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCCC1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
CHEMBL437777 175605 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 576 11 3 6 3.9 O=C(NC1(C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCCC1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
44577884 177552 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 604 12 3 6 3.7 COc1cccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)c1 10.1016/j.bmcl.2008.06.102
CHEMBL445284 177552 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 604 12 3 6 3.7 COc1cccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)c1 10.1016/j.bmcl.2008.06.102
44577896 177690 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 631 14 3 6 4.4 CCCCc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)nc1 10.1016/j.bmcl.2008.06.102
CHEMBL445493 177690 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 631 14 3 6 4.4 CCCCc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)nc1 10.1016/j.bmcl.2008.06.102
44421492 144050 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 939 14 12 12 -2.4 CC(=O)N[C@@H](CC(=O)N[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1NC(C)=O)C(=O)N[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1021/jm040832y
CHEMBL375214 144050 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 939 14 12 12 -2.4 CC(=O)N[C@@H](CC(=O)N[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1NC(C)=O)C(=O)N[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1021/jm040832y
23625786 92752 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 557 11 3 6 2.8 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1ccc2ncccc2c1 10.1021/jm070289w
CHEMBL230326 92752 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 557 11 3 6 2.8 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1ccc2ncccc2c1 10.1021/jm070289w
44390560 72167 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 570 11 3 5 5.1 O=C(Nc1ccc(Oc2ccc(C(F)(F)F)cc2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL182947 72167 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 570 11 3 5 5.1 O=C(Nc1ccc(Oc2ccc(C(F)(F)F)cc2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
10077178 109958 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 592 12 0 8 5.0 CCOC(=O)C1=C(C)OC2OC(COCc3ccccc3)C(OCc3ccccc3)C(OCc3ccccc3)C2[S+]1[O-] 10.1016/s0960-894x(02)00471-7
CHEMBL308176 109958 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 592 12 0 8 5.0 CCOC(=O)C1=C(C)OC2OC(COCc3ccccc3)C(OCc3ccccc3)C(OCc3ccccc3)C2[S+]1[O-] 10.1016/s0960-894x(02)00471-7
86274727 167562 0 None -1047 3 Human 4.6 pKi = 4.6 Binding
Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 392 2 0 7 3.1 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)c(Cl)c2)[C@@H]3C)n1 nan
CHEMBL4114280 167562 0 None -1047 3 Human 4.6 pKi = 4.6 Binding
Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 392 2 0 7 3.1 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)c(Cl)c2)[C@@H]3C)n1 nan
44434177 95953 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 548 13 4 5 4.7 NCCCCCCNC(=O)C(Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
CHEMBL236661 95953 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 548 13 4 5 4.7 NCCCCCCNC(=O)C(Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
44329148 115717 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 359 7 4 6 3.6 CC(C)c1nc2[nH]c(NCCCN)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
CHEMBL321137 115717 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 359 7 4 6 3.6 CC(C)c1nc2[nH]c(NCCCN)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
44314298 211921 0 None -4 2 Human 6.6 pKi = 6.6 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 682 13 1 6 6.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)NC2CC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL78065 211921 0 None -4 2 Human 6.6 pKi = 6.6 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 682 13 1 6 6.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)NC2CC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44363990 23084 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 749 14 0 5 9.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(CC3CC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL122643 23084 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 749 14 0 5 9.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(CC3CC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44363912 125535 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 681 12 0 5 8.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL341843 125535 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 681 12 0 5 8.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
49863734 22105 0 None -13 4 Rat 7.6 pKi = 7.6 Binding
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 1477 21 11 14 6.8 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm100157m
CHEMBL1214027 22105 0 None -13 4 Rat 7.6 pKi = 7.6 Binding
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 1477 21 11 14 6.8 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm100157m
44314299 211924 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 739 13 1 7 5.8 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC[C@H]2C(N)=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL78070 211924 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 739 13 1 7 5.8 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC[C@H]2C(N)=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
52918298 65261 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins
ChEMBL 631 14 3 6 4.4 CCCCc1ccc(C(=O)NC2(C(=O)N[C@@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)nc1 10.1016/j.bmcl.2011.01.074
CHEMBL1683150 65261 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins
ChEMBL 631 14 3 6 4.4 CCCCc1ccc(C(=O)NC2(C(=O)N[C@@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)nc1 10.1016/j.bmcl.2011.01.074
44314578 211927 0 None -13 2 Human 6.6 pKi = 6.6 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 726 14 1 7 6.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)NCC2CCCO2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL78091 211927 0 None -13 2 Human 6.6 pKi = 6.6 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 726 14 1 7 6.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)NCC2CCCO2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44337289 114815 0 None -3 2 Human 7.6 pKi = 7.6 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 624 9 1 6 5.3 COc1cc(OC)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL319474 114815 0 None -3 2 Human 7.6 pKi = 7.6 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 624 9 1 6 5.3 COc1cc(OC)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44363963 128055 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 724 13 1 6 7.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(C(N)=O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL357853 128055 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 724 13 1 6 7.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(C(N)=O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44337370 114193 0 None -147 2 Human 6.6 pKi = 6.6 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 700 7 1 4 7.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)[C@@H](c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL318081 114193 0 None -147 2 Human 6.6 pKi = 6.6 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 700 7 1 4 7.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)[C@@H](c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL2112592 216019 0 None 1 2 Human 4.6 pKi = 4.6 Binding
Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)
ChEMBL None None None CC(C)[C@@H]1NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)[C@H](Cc2ccc(OC(C)(C)C)cc2)NC(=O)CNC1=O 10.1021/jm00029a007
10837820 186013 0 None -38 2 Human 6.6 pKi = 6.6 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 463 7 1 3 6.8 CC[C@H](NC(=O)c1c(CN2CCCCC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm000501v
CHEMBL47275 186013 0 None -38 2 Human 6.6 pKi = 6.6 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 463 7 1 3 6.8 CC[C@H](NC(=O)c1c(CN2CCCCC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm000501v
2131 10272 69 None -34 2 Human 6.6 pKi = 6.6 Binding
Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)
ChEMBL 380 5 1 2 6.1 CC[C@@H](c1ccccc1)NC(=O)c1c(C)c(nc2c1cccc2)c1ccccc1 10.1021/jm9602423
6604009 10272 69 None -34 2 Human 6.6 pKi = 6.6 Binding
Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)
ChEMBL 380 5 1 2 6.1 CC[C@@H](c1ccccc1)NC(=O)c1c(C)c(nc2c1cccc2)c1ccccc1 10.1021/jm9602423
CHEMBL10284 10272 69 None -34 2 Human 6.6 pKi = 6.6 Binding
Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)
ChEMBL 380 5 1 2 6.1 CC[C@@H](c1ccccc1)NC(=O)c1c(C)c(nc2c1cccc2)c1ccccc1 10.1021/jm9602423
10619783 11454 1 None -5 2 Human 6.6 pKi = 6.6 Binding
Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 380 5 1 2 6.1 CC[C@@H](NC(=O)c1c(C)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm980633c
CHEMBL10334 11454 1 None -5 2 Human 6.6 pKi = 6.6 Binding
Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 380 5 1 2 6.1 CC[C@@H](NC(=O)c1c(C)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm980633c
44337324 13483 0 None 2 2 Human 7.6 pKi = 7.6 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 688 8 3 5 5.3 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)Cc4c[nH]c5ccccc45)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL108364 13483 0 None 2 2 Human 7.6 pKi = 7.6 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 688 8 3 5 5.3 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)Cc4c[nH]c5ccccc45)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44281771 106416 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 630 14 1 8 6.7 CO/N=C(\COCc1cc(OC)c(OC)c(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL284269 106416 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 630 14 1 8 6.7 CO/N=C(\COCc1cc(OC)c(OC)c(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44363962 42704 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 753 14 0 7 8.7 CCOC(=O)C1CCCN(CC2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1 10.1016/s0960-894x(00)00702-2
CHEMBL144249 42704 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 753 14 0 7 8.7 CCOC(=O)C1CCCN(CC2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1 10.1016/s0960-894x(00)00702-2
44314871 112470 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 712 12 0 7 6.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCOCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL312573 112470 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 712 12 0 7 6.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCOCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
23625783 99637 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 663 11 4 5 3.5 O=C(NCCCN1CCOCC1)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=S)Nc2ccc(I)cc2)CCCC1 10.1021/jm070289w
CHEMBL243933 99637 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 663 11 4 5 3.5 O=C(NCCCN1CCOCC1)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=S)Nc2ccc(I)cc2)CCCC1 10.1021/jm070289w
86275688 155086 0 None -1071 3 Human 4.6 pKi = 4.6 Binding
Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 408 2 0 7 3.6 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(Cl)c2)C3C)n1 nan
CHEMBL3936869 155086 0 None -1071 3 Human 4.6 pKi = 4.6 Binding
Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 408 2 0 7 3.6 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(Cl)c2)C3C)n1 nan
44329339 119383 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 406 4 2 6 4.0 CC(C)c1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(C(F)(F)F)cc3)c-2n1 10.1016/0960-894X(95)00502-K
CHEMBL330220 119383 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 406 4 2 6 4.0 CC(C)c1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(C(F)(F)F)cc3)c-2n1 10.1016/0960-894X(95)00502-K
44281744 120251 0 None 1 2 Human 6.5 pKi = 6.5 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 739 11 1 6 7.8 CO/N=C(\CN(C)S(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33194 120251 0 None 1 2 Human 6.5 pKi = 6.5 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 739 11 1 6 7.8 CO/N=C(\CN(C)S(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
2683 109665 25 None -398 16 Human 5.5 pKi = 5.5 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 304 15 0 0 6.5 CCCCCCCCCCCCCCCC[n+]1ccccc1 nan
CHEMBL305906 109665 25 None -398 16 Human 5.5 pKi = 5.5 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 304 15 0 0 6.5 CCCCCCCCCCCCCCCC[n+]1ccccc1 nan
CHEMBL334255 109665 25 None -398 16 Human 5.5 pKi = 5.5 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 304 15 0 0 6.5 CCCCCCCCCCCCCCCC[n+]1ccccc1 nan
4529080 174272 7 None -93 2 Human 5.5 pKi = 5.5 Binding
Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)
ChEMBL 396 5 1 4 4.5 COC(=O)C(NC(=O)c1cc(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm9602423
CHEMBL429951 174272 7 None -93 2 Human 5.5 pKi = 5.5 Binding
Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)
ChEMBL 396 5 1 4 4.5 COC(=O)C(NC(=O)c1cc(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm9602423
4529080 174272 7 None -93 2 Human 5.5 pKi = 5.5 Binding
Inhibition of [125I]neurokinin A (NKA) binding in human Tachykinin receptor 2 of chinese hamster ovary (hNK-2-CHO) cell membranes.Inhibition of [125I]neurokinin A (NKA) binding in human Tachykinin receptor 2 of chinese hamster ovary (hNK-2-CHO) cell membranes.
ChEMBL 396 5 1 4 4.5 COC(=O)C(NC(=O)c1cc(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm960818o
CHEMBL429951 174272 7 None -93 2 Human 5.5 pKi = 5.5 Binding
Inhibition of [125I]neurokinin A (NKA) binding in human Tachykinin receptor 2 of chinese hamster ovary (hNK-2-CHO) cell membranes.Inhibition of [125I]neurokinin A (NKA) binding in human Tachykinin receptor 2 of chinese hamster ovary (hNK-2-CHO) cell membranes.
ChEMBL 396 5 1 4 4.5 COC(=O)C(NC(=O)c1cc(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm960818o
44329600 10987 0 None - 1 Golden hamster 4.5 pKi = 4.5 Binding
Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)
ChEMBL 340 3 1 5 3.9 Clc1ccc(Nc2nc(N3CCOCC3)nc3ccccc23)cc1 10.1016/0960-894X(95)00502-K
CHEMBL100264 10987 0 None - 1 Golden hamster 4.5 pKi = 4.5 Binding
Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)
ChEMBL 340 3 1 5 3.9 Clc1ccc(Nc2nc(N3CCOCC3)nc3ccccc23)cc1 10.1016/0960-894X(95)00502-K
44337173 13461 0 None 30 2 Human 8.5 pKi = 8.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 582 7 2 5 4.6 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ncc[nH]4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL108350 13461 0 None 30 2 Human 8.5 pKi = 8.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 582 7 2 5 4.6 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ncc[nH]4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44281650 120574 0 None -1 2 Human 8.5 pKi = 8.5 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 651 11 1 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(C)nc(N2CCCC2)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33243 120574 0 None -1 2 Human 8.5 pKi = 8.5 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 651 11 1 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(C)nc(N2CCCC2)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44282002 132284 0 None 4 2 Human 8.5 pKi = 8.5 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 657 13 1 8 6.3 CO/N=C(\CN(C)C(=O)c1cc(OC)c(OC)c(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL36462 132284 0 None 4 2 Human 8.5 pKi = 8.5 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 657 13 1 8 6.3 CO/N=C(\CN(C)C(=O)c1cc(OC)c(OC)c(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
9810288 210470 0 None -8 2 Guinea pig 8.5 pKi = 8.5 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL67508 210470 0 None -8 2 Guinea pig 8.5 pKi = 8.5 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44315421 112505 0 None -2 3 Human 8.5 pKi = 8.5 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 765 14 1 8 7.4 CO/N=C(\CN(CCF)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(CC(=O)O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL312612 112505 0 None -2 3 Human 8.5 pKi = 8.5 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 765 14 1 8 7.4 CO/N=C(\CN(CCF)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(CC(=O)O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44380090 127498 0 None -1 2 Human 8.5 pKi = 8.5 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 684 13 0 6 7.0 COCCO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL354771 127498 0 None -1 2 Human 8.5 pKi = 8.5 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 684 13 0 6 7.0 COCCO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
25109291 198165 10 None -72 8 Human 8.5 pKi = 8.5 Binding
Displacement of radiolabeled [Nle10]-NKA(4-10) from human NK2 receptorDisplacement of radiolabeled [Nle10]-NKA(4-10) from human NK2 receptor
ChEMBL 327 1 2 6 1.7 Nc1nc2c(c(N3CCNCC3)n1)CCC1=C2[C@@H]2CCCC[C@@H]2O1 10.1021/jm8007618
CHEMBL519240 198165 10 None -72 8 Human 8.5 pKi = 8.5 Binding
Displacement of radiolabeled [Nle10]-NKA(4-10) from human NK2 receptorDisplacement of radiolabeled [Nle10]-NKA(4-10) from human NK2 receptor
ChEMBL 327 1 2 6 1.7 Nc1nc2c(c(N3CCNCC3)n1)CCC1=C2[C@@H]2CCCC[C@@H]2O1 10.1021/jm8007618
44577892 178602 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 620 12 3 6 4.4 CSc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
CHEMBL446853 178602 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 620 12 3 6 4.4 CSc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
11285910 148817 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 727 8 5 7 1.1 CS(=O)(=O)N1CCN([C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
CHEMBL387700 148817 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 727 8 5 7 1.1 CS(=O)(=O)N1CCN([C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
11181079 170338 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 580 6 6 5 1.5 N[C@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1021/jm040832y
CHEMBL420308 170338 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 580 6 6 5 1.5 N[C@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1021/jm040832y
11296497 175690 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 580 6 6 5 1.5 N[C@H]1CC(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm040832y
CHEMBL438559 175690 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 580 6 6 5 1.5 N[C@H]1CC(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm040832y
23626109 173469 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 576 11 4 6 3.6 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCC(O)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
CHEMBL428217 173469 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 576 11 4 6 3.6 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCC(O)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
44342780 116934 0 None - 1 Human 8.5 pKi = 8.5 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 604 6 6 4 3.0 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2c[nH]c3ccccc23)CN1 10.1021/jm011127h
CHEMBL323677 116934 0 None - 1 Human 8.5 pKi = 8.5 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 604 6 6 4 3.0 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2c[nH]c3ccccc23)CN1 10.1021/jm011127h
44343083 117171 0 None - 1 Human 8.5 pKi = 8.5 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 585 6 5 5 2.6 O=C1CCC(=O)N[C@@H](CC2CNc3ccc(F)cc32)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1 10.1021/jm011127h
CHEMBL324313 117171 0 None - 1 Human 8.5 pKi = 8.5 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 585 6 5 5 2.6 O=C1CCC(=O)N[C@@H](CC2CNc3ccc(F)cc32)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1 10.1021/jm011127h
11181079 170338 0 None - 1 Human 8.5 pKi = 8.5 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 580 6 6 5 1.5 N[C@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1021/jm011127h
CHEMBL420308 170338 0 None - 1 Human 8.5 pKi = 8.5 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 580 6 6 5 1.5 N[C@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1021/jm011127h
11296497 175690 0 None - 1 Human 8.5 pKi = 8.5 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 580 6 6 5 1.5 N[C@H]1CC(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm011127h
CHEMBL438559 175690 0 None - 1 Human 8.5 pKi = 8.5 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 580 6 6 5 1.5 N[C@H]1CC(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm011127h
44380131 64387 0 None -3 2 Human 8.5 pKi = 8.5 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 746 14 0 7 6.8 CN(C/C(=N\OCCCS(C)(=O)=O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL166828 64387 0 None -3 2 Human 8.5 pKi = 8.5 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 746 14 0 7 6.8 CN(C/C(=N\OCCCS(C)(=O)=O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44337330 12104 0 None 6 2 Human 8.5 pKi = 8.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 649 8 2 5 4.8 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@@H](N)Cc4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL106816 12104 0 None 6 2 Human 8.5 pKi = 8.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 649 8 2 5 4.8 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@@H](N)Cc4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
53322827 65259 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins
ChEMBL 657 12 3 6 4.6 O=C(NC1(C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1ccc(-n2cccc2)cc1F 10.1016/j.bmcl.2011.01.074
CHEMBL1683148 65259 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins
ChEMBL 657 12 3 6 4.6 O=C(NC1(C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1ccc(-n2cccc2)cc1F 10.1016/j.bmcl.2011.01.074
44337266 12070 0 None 27 2 Human 8.5 pKi = 8.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 564 7 1 4 5.3 O=C(c1ccccc1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL106608 12070 0 None 27 2 Human 8.5 pKi = 8.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 564 7 1 4 5.3 O=C(c1ccccc1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
44337313 115380 0 None 7 2 Human 8.5 pKi = 8.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL320487 115380 0 None 7 2 Human 8.5 pKi = 8.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44380132 103202 0 None -4 2 Human 8.5 pKi = 8.5 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 730 14 0 6 7.2 CN(C/C(=N\OCCC[S+](C)[O-])C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL262053 103202 0 None -4 2 Human 8.5 pKi = 8.5 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 730 14 0 6 7.2 CN(C/C(=N\OCCC[S+](C)[O-])C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
9914111 203478 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 504 10 1 3 6.5 CCC(O)(CC)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
CHEMBL56481 203478 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 504 10 1 3 6.5 CCC(O)(CC)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
44315590 174587 0 None -1 3 Human 8.4 pKi = 8.4 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 774 14 1 8 7.5 CCNC(=O)Cn1c(=O)n(C2CCN(CC[C@@H](/C(CN(CC)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(02)00462-6
CHEMBL430609 174587 0 None -1 3 Human 8.4 pKi = 8.4 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 774 14 1 8 7.5 CCNC(=O)Cn1c(=O)n(C2CCN(CC[C@@H](/C(CN(CC)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(02)00462-6
22405764 203928 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 490 10 1 3 6.1 CCCC(O)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
CHEMBL56788 203928 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 490 10 1 3 6.1 CCCC(O)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
23626252 99337 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 576 12 4 6 3.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCNC2CCOCC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
CHEMBL243278 99337 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 576 12 4 6 3.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCNC2CCOCC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
23625637 157705 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 613 11 4 5 3.8 Cc1cc(NC(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)CCCC2)ccc1Br 10.1021/jm070289w
CHEMBL395774 157705 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 613 11 4 5 3.8 Cc1cc(NC(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)CCCC2)ccc1Br 10.1021/jm070289w
10025437 22413 0 None - 1 Rat 8.4 pKi = 8.4 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 425 5 1 3 4.5 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccc(F)cc1 10.1021/jm00019a006
CHEMBL122169 22413 0 None - 1 Rat 8.4 pKi = 8.4 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 425 5 1 3 4.5 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccc(F)cc1 10.1021/jm00019a006
10048714 23365 0 None - 1 Rat 8.4 pKi = 8.4 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 437 6 1 4 4.3 COc1ccc(CN2CC3(CCN(CCc4c[nH]c5ccc(F)cc45)CC3)OC2=O)cc1 10.1021/jm00019a006
CHEMBL124013 23365 0 None - 1 Rat 8.4 pKi = 8.4 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 437 6 1 4 4.3 COc1ccc(CN2CC3(CCN(CCc4c[nH]c5ccc(F)cc45)CC3)OC2=O)cc1 10.1021/jm00019a006
44301859 206591 0 None 35481 2 Rat 8.4 pKi = 8.4 Binding
Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon
ChEMBL 400 6 2 3 3.5 [O-][S@+](CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1)c1ccccc1 10.1016/S0960-894X(01)80541-2
CHEMBL59413 206591 0 None 35481 2 Rat 8.4 pKi = 8.4 Binding
Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon
ChEMBL 400 6 2 3 3.5 [O-][S@+](CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1)c1ccccc1 10.1016/S0960-894X(01)80541-2
10305816 10991 1 None - 1 Human 8.4 pKi = 8.4 Binding
Compound was tested for it's binding affinity against human Tachykinin receptor 2Compound was tested for it's binding affinity against human Tachykinin receptor 2
ChEMBL 736 16 2 6 6.9 O=C(c1ccccc1C(=O)N(CCCN1CCSCC1)CCc1c[nH]c2ccccc12)N(CCCN1CCSCC1)CCc1c[nH]c2ccccc12 10.1016/s0960-894x(02)00539-5
CHEMBL100298 10991 1 None - 1 Human 8.4 pKi = 8.4 Binding
Compound was tested for it's binding affinity against human Tachykinin receptor 2Compound was tested for it's binding affinity against human Tachykinin receptor 2
ChEMBL 736 16 2 6 6.9 O=C(c1ccccc1C(=O)N(CCCN1CCSCC1)CCc1c[nH]c2ccccc12)N(CCCN1CCSCC1)CCc1c[nH]c2ccccc12 10.1016/s0960-894x(02)00539-5
44434193 95346 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 589 11 3 6 3.8 CN1CCN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCCCC2)CC1 10.1016/j.bmcl.2007.06.053
CHEMBL235431 95346 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 589 11 3 6 3.8 CN1CCN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCCCC2)CC1 10.1016/j.bmcl.2007.06.053
44434185 96288 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 560 11 3 5 4.7 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCCC2)CCCCC1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
CHEMBL237304 96288 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 560 11 3 5 4.7 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCCC2)CCCCC1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
44577887 176405 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 646 15 3 6 4.9 CCCCOc1cccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)c1 10.1016/j.bmcl.2008.06.102
CHEMBL443691 176405 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 646 15 3 6 4.9 CCCCOc1cccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)c1 10.1016/j.bmcl.2008.06.102
44577897 176713 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 618 12 3 5 4.3 O=C(/C=C/c1ccccc1F)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1 10.1016/j.bmcl.2008.06.102
CHEMBL444142 176713 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 618 12 3 5 4.3 O=C(/C=C/c1ccccc1F)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1 10.1016/j.bmcl.2008.06.102
44577888 180654 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 618 13 3 6 4.1 CCOc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
CHEMBL453961 180654 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 618 13 3 6 4.1 CCOc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
71449112 85674 0 None -1 2 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 682 10 8 7 0.3 O=C1CC(C(=O)NC(CO)CO)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
CHEMBL2112926 85674 0 None -1 2 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 682 10 8 7 0.3 O=C1CC(C(=O)NC(CO)CO)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
53326714 65258 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins
ChEMBL 673 12 3 6 5.2 O=C(NC1(C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1ccc(-n2cccc2)cc1Cl 10.1016/j.bmcl.2011.01.074
CHEMBL1683147 65258 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins
ChEMBL 673 12 3 6 5.2 O=C(NC1(C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1ccc(-n2cccc2)cc1Cl 10.1016/j.bmcl.2011.01.074
44421495 91944 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 920 15 14 15 -4.1 O=C1CC(NC(=O)[C@@H](O)[C@H](O)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O)[C@@H](O)CO)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL225264 91944 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 920 15 14 15 -4.1 O=C1CC(NC(=O)[C@@H](O)[C@H](O)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O)[C@@H](O)CO)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
10372391 16621 0 None - 1 Human 8.4 pKi = 8.4 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 679 9 9 6 0.1 N=C(N)NCC(=O)N[C@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1021/jm011127h
CHEMBL114068 16621 0 None - 1 Human 8.4 pKi = 8.4 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 679 9 9 6 0.1 N=C(N)NCC(=O)N[C@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1021/jm011127h
44342904 17298 0 None - 1 Human 8.4 pKi = 8.4 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 676 9 6 9 0.3 O=C(Cn1cnnn1)N[C@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)NC1=O 10.1021/jm011127h
CHEMBL116871 17298 0 None - 1 Human 8.4 pKi = 8.4 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 676 9 6 9 0.3 O=C(Cn1cnnn1)N[C@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)NC1=O 10.1021/jm011127h
44314502 211576 0 None -1 2 Human 7.5 pKi = 7.5 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 712 12 1 7 5.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL75018 211576 0 None -1 2 Human 7.5 pKi = 7.5 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 712 12 1 7 5.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
23625326 156158 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 596 11 3 6 4.2 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1sc2ccccc2c1Cl 10.1021/jm070289w
CHEMBL394543 156158 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 596 11 3 6 4.2 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1sc2ccccc2c1Cl 10.1021/jm070289w
44391011 71145 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 502 11 3 5 4.1 O=C(Nc1cccc(Oc2ccccc2)c1)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL181291 71145 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 502 11 3 5 4.1 O=C(Nc1cccc(Oc2ccccc2)c1)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
44337467 116992 0 None -17 2 Human 6.5 pKi = 6.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 821 13 2 7 7.8 O=C(CN(NC1CCN(Cc2ccccc2)CC1)NC1CCN(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccccc1 10.1016/s0960-894x(02)00645-5
CHEMBL323741 116992 0 None -17 2 Human 6.5 pKi = 6.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 821 13 2 7 7.8 O=C(CN(NC1CCN(Cc2ccccc2)CC1)NC1CCN(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccccc1 10.1016/s0960-894x(02)00645-5
44391005 129109 0 None - 1 Human 5.5 pKi = 5.5 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 438 10 2 4 2.3 CN(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL359885 129109 0 None - 1 Human 5.5 pKi = 5.5 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 438 10 2 4 2.3 CN(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
44391123 129137 0 None - 1 Human 5.5 pKi = 5.5 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 471 10 2 4 3.5 O=C(N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1)c1ccccc1-c1ccccc1 10.1016/j.bmcl.2004.11.045
CHEMBL360023 129137 0 None - 1 Human 5.5 pKi = 5.5 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 471 10 2 4 3.5 O=C(N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1)c1ccccc1-c1ccccc1 10.1016/j.bmcl.2004.11.045
86275685 152056 0 None -416 2 Human 4.5 pKi = 4.5 Binding
Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 392 2 0 7 3.1 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)c(Cl)c2)C3C)n1 nan
CHEMBL3913001 152056 0 None -416 2 Human 4.5 pKi = 4.5 Binding
Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 392 2 0 7 3.1 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)c(Cl)c2)C3C)n1 nan
10022196 215066 0 None -45 2 Human 5.5 pKi = 5.5 Binding
Inhibition constant for displacement of [3H]-NKA from the cloned human NK2 receptor which has been expressed in baculovirus infected insect sf21 cellsInhibition constant for displacement of [3H]-NKA from the cloned human NK2 receptor which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 372 4 2 6 3.7 CC(C)c1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
CHEMBL98977 215066 0 None -45 2 Human 5.5 pKi = 5.5 Binding
Inhibition constant for displacement of [3H]-NKA from the cloned human NK2 receptor which has been expressed in baculovirus infected insect sf21 cellsInhibition constant for displacement of [3H]-NKA from the cloned human NK2 receptor which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 372 4 2 6 3.7 CC(C)c1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
44314503 211772 0 None -1 2 Human 7.5 pKi = 7.5 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 698 12 1 7 5.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL76704 211772 0 None -1 2 Human 7.5 pKi = 7.5 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 698 12 1 7 5.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
9931729 107770 0 None - 1 Rat 7.5 pKi = 7.5 Binding
Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon
ChEMBL 416 6 2 4 3.2 O=S(=O)(CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1)c1ccccc1 10.1016/S0960-894X(01)80541-2
CHEMBL294336 107770 0 None - 1 Rat 7.5 pKi = 7.5 Binding
Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon
ChEMBL 416 6 2 4 3.2 O=S(=O)(CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1)c1ccccc1 10.1016/S0960-894X(01)80541-2
44301695 208168 0 None - 1 Rat 7.5 pKi = 7.5 Binding
Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon
ChEMBL 382 6 2 3 4.1 Cc1ccccc1OCC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1 10.1016/S0960-894X(01)80541-2
CHEMBL60459 208168 0 None - 1 Rat 7.5 pKi = 7.5 Binding
Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon
ChEMBL 382 6 2 3 4.1 Cc1ccccc1OCC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1 10.1016/S0960-894X(01)80541-2
10122872 114538 0 None - 1 Human 7.5 pKi = 7.5 Binding
Compound was tested for it's binding affinity against human Tachykinin receptor 2Compound was tested for it's binding affinity against human Tachykinin receptor 2
ChEMBL 704 16 2 6 5.5 O=C(c1ccccc1C(=O)N(CCCN1CCOCC1)CCc1c[nH]c2ccccc12)N(CCCN1CCOCC1)CCc1c[nH]c2ccccc12 10.1016/s0960-894x(02)00539-5
CHEMBL319154 114538 0 None - 1 Human 7.5 pKi = 7.5 Binding
Compound was tested for it's binding affinity against human Tachykinin receptor 2Compound was tested for it's binding affinity against human Tachykinin receptor 2
ChEMBL 704 16 2 6 5.5 O=C(c1ccccc1C(=O)N(CCCN1CCOCC1)CCc1c[nH]c2ccccc12)N(CCCN1CCOCC1)CCc1c[nH]c2ccccc12 10.1016/s0960-894x(02)00539-5
44434195 95369 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 652 17 3 5 6.6 CCCCN(CCCC)CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCc2ccccc21 10.1016/j.bmcl.2007.06.053
CHEMBL235574 95369 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 652 17 3 5 6.6 CCCCN(CCCC)CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCc2ccccc21 10.1016/j.bmcl.2007.06.053
44434186 161572 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 576 12 3 5 5.3 CC(C)N(CCNC(=O)C(Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1)C(C)C 10.1016/j.bmcl.2007.06.053
CHEMBL400209 161572 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 576 12 3 5 5.3 CC(C)N(CCNC(=O)C(Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1)C(C)C 10.1016/j.bmcl.2007.06.053
44391033 130336 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 487 11 2 5 3.1 CC(C)(Oc1cccc(Cl)c1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL361815 130336 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 487 11 2 5 3.1 CC(C)(Oc1cccc(Cl)c1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
44390451 172964 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 532 12 3 6 4.1 COc1ccc(Oc2ccc(NC(=O)N[C@@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc1 10.1016/j.bmcl.2004.11.045
CHEMBL426421 172964 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 532 12 3 6 4.1 COc1ccc(Oc2ccc(NC(=O)N[C@@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc1 10.1016/j.bmcl.2004.11.045
44391026 130690 0 None - 1 Human 5.5 pKi = 5.5 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 529 12 2 5 4.1 CC(C)(Oc1ccccc1-c1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL362800 130690 0 None - 1 Human 5.5 pKi = 5.5 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 529 12 2 5 4.1 CC(C)(Oc1ccccc1-c1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL2111789 215998 0 None 3 2 Human 4.5 pKi = 4.5 Binding
Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)
ChEMBL None None None CC(C)[C@@H]1NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)[C@H](Cc2ccc(OC(C)(C)C)cc2)NC(=O)CNC1=O 10.1021/jm00029a007
44266551 105104 0 None -58 2 Human 6.5 pKi = 6.5 Binding
Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 394 6 1 2 6.3 CCc1c(-c2ccccc2)nc2ccccc2c1C(=O)N[C@H](CC)c1ccccc1 10.1021/jm980633c
CHEMBL275017 105104 0 None -58 2 Human 6.5 pKi = 6.5 Binding
Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 394 6 1 2 6.3 CCc1c(-c2ccccc2)nc2ccccc2c1C(=O)N[C@H](CC)c1ccccc1 10.1021/jm980633c
10626894 16694 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 571 6 5 4 3.3 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](CC2CCCCC2)CN1 10.1021/jm0010217
CHEMBL114442 16694 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 571 6 5 4 3.3 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](CC2CCCCC2)CN1 10.1021/jm0010217
44434162 152600 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 489 8 3 4 4.3 O=C(NC1(C(=O)N[C@@H](Cc2ccccc2)C(=O)NC2CC2)CCCCC1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
CHEMBL391710 152600 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 489 8 3 4 4.3 O=C(NC1(C(=O)N[C@@H](Cc2ccccc2)C(=O)NC2CC2)CCCCC1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
44434163 153638 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 534 11 3 5 4.1 CN(C)CCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
CHEMBL392523 153638 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 534 11 3 5 4.1 CN(C)CCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
44434160 174127 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 562 11 4 5 4.1 CC(C)C[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1)C(N)=O 10.1016/j.bmcl.2007.06.053
CHEMBL429452 174127 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 562 11 4 5 4.1 CC(C)C[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1)C(N)=O 10.1016/j.bmcl.2007.06.053
10626894 16694 0 None - 1 Human 6.5 pKi = 6.5 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 571 6 5 4 3.3 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](CC2CCCCC2)CN1 10.1021/jm011127h
CHEMBL114442 16694 0 None - 1 Human 6.5 pKi = 6.5 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 571 6 5 4 3.3 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](CC2CCCCC2)CN1 10.1021/jm011127h
10985363 17294 0 None - 1 Human 6.5 pKi = 6.5 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 703 9 5 6 3.6 C=CCOC(=O)[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(Cl)c(Cl)c2)C(=O)N1 10.1021/jm011127h
CHEMBL116855 17294 0 None - 1 Human 6.5 pKi = 6.5 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 703 9 5 6 3.6 C=CCOC(=O)[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(Cl)c(Cl)c2)C(=O)N1 10.1021/jm011127h
10875451 117135 0 None - 1 Human 6.5 pKi = 6.5 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 565 6 5 4 2.6 O=C1CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm011127h
CHEMBL324106 117135 0 None - 1 Human 6.5 pKi = 6.5 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 565 6 5 4 2.6 O=C1CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm011127h
448537 167029 89 None -26 25 Human 5.5 pKi = 5.5 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 268 4 2 2 4.8 CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 nan
CHEMBL411 167029 89 None -26 25 Human 5.5 pKi = 5.5 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 268 4 2 2 4.8 CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 nan
44390446 71238 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 550 12 3 5 4.5 O=C(Nc1ccc(OCc2cccc(Cl)c2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL181359 71238 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 550 12 3 5 4.5 O=C(Nc1ccc(OCc2cccc(Cl)c2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
86275451 166872 0 None -4466 3 Human 4.5 pKi = 4.5 Binding
Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 420 4 0 8 3.8 CCc1noc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)n1 nan
CHEMBL4108623 166872 0 None -4466 3 Human 4.5 pKi = 4.5 Binding
Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 420 4 0 8 3.8 CCc1noc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)n1 nan
10668461 86238 0 None -181 2 Human 6.5 pKi = 6.5 Binding
Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 396 6 1 3 5.8 CC[C@H](NC(=O)c1c(OC)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm980633c
CHEMBL2113673 86238 0 None -181 2 Human 6.5 pKi = 6.5 Binding
Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 396 6 1 3 5.8 CC[C@H](NC(=O)c1c(OC)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm980633c
44363936 26807 0 None -1 2 Human 7.5 pKi = 7.5 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 782 14 1 7 9.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(OC(=O)NC(C)C)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL130354 26807 0 None -1 2 Human 7.5 pKi = 7.5 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 782 14 1 7 9.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(OC(=O)NC(C)C)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
10552329 174823 0 None -1 3 Human 7.5 pKi = 7.5 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 470 6 2 4 5.5 C[C@H](NC(=O)c1c(CN2CCC(N)CC2)c(-c2ccccc2)nc2ccccc12)C1CCCCC1 10.1021/jm000501v
CHEMBL432301 174823 0 None -1 3 Human 7.5 pKi = 7.5 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 470 6 2 4 5.5 C[C@H](NC(=O)c1c(CN2CCC(N)CC2)c(-c2ccccc2)nc2ccccc12)C1CCCCC1 10.1021/jm000501v
9874473 48582 0 None -16 3 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligandIn vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
CHEMBL149326 48582 0 None -16 3 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligandIn vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
44314504 109693 0 None -1 2 Human 7.5 pKi = 7.5 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 682 12 0 6 6.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL306121 109693 0 None -1 2 Human 7.5 pKi = 7.5 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 682 12 0 6 6.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
22405732 203174 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 462 8 1 3 5.3 CC(O)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
CHEMBL56274 203174 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 462 8 1 3 5.3 CC(O)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
11496610 10847 13 None 2 2 Human 6.5 pKi = 6.5 Binding
Inhibition of human neurokinin NK2 receptorInhibition of human neurokinin NK2 receptor
ChEMBL 476 4 1 5 5.8 CC(c1ccc(cc1)c1[nH]c2c(n1)cccc2N1CCN(CC1)Cc1ccc2c(c1)nccn2)(C)C 10.1021/jm801572m
5582 10847 13 None 2 2 Human 6.5 pKi = 6.5 Binding
Inhibition of human neurokinin NK2 receptorInhibition of human neurokinin NK2 receptor
ChEMBL 476 4 1 5 5.8 CC(c1ccc(cc1)c1[nH]c2c(n1)cccc2N1CCN(CC1)Cc1ccc2c(c1)nccn2)(C)C 10.1021/jm801572m
CHEMBL474991 10847 13 None 2 2 Human 6.5 pKi = 6.5 Binding
Inhibition of human neurokinin NK2 receptorInhibition of human neurokinin NK2 receptor
ChEMBL 476 4 1 5 5.8 CC(c1ccc(cc1)c1[nH]c2c(n1)cccc2N1CCN(CC1)Cc1ccc2c(c1)nccn2)(C)C 10.1021/jm801572m
73353047 96181 0 None -1 2 Human 4.5 pKi = 4.5 Binding
Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)
ChEMBL 746 6 8 9 -1.1 COc1ccc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)cc1 10.1021/jm00029a007
CHEMBL2370509 96181 0 None -1 2 Human 4.5 pKi = 4.5 Binding
Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)
ChEMBL 746 6 8 9 -1.1 COc1ccc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)cc1 10.1021/jm00029a007
44281358 105039 0 None -3 2 Human 6.5 pKi = 6.5 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 674 11 1 4 9.5 CO/N=C(\CCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL274557 105039 0 None -3 2 Human 6.5 pKi = 6.5 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 674 11 1 4 9.5 CO/N=C(\CCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
2812 11551 101 None -28 34 Human 5.5 pKi = 5.5 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 nan
CHEMBL104 11551 101 None -28 34 Human 5.5 pKi = 5.5 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 nan
44314868 162477 0 None -3 2 Human 7.5 pKi = 7.5 Binding
Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand
ChEMBL 705 13 3 5 7.1 NC(=O)CN[C@@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL405129 162477 0 None -3 2 Human 7.5 pKi = 7.5 Binding
Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand
ChEMBL 705 13 3 5 7.1 NC(=O)CN[C@@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
44314867 164106 0 None -8 2 Human 7.5 pKi = 7.5 Binding
Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand
ChEMBL 705 13 3 5 7.1 NC(=O)CNC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL407749 164106 0 None -8 2 Human 7.5 pKi = 7.5 Binding
Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand
ChEMBL 705 13 3 5 7.1 NC(=O)CNC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
44329374 215065 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 430 6 2 7 4.5 COC1(OC)CCN(c2nc(Nc3ccc(Cl)cc3)c3[nH]c(C(C)C)nc3n2)CC1 10.1016/0960-894X(95)00502-K
CHEMBL98976 215065 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 430 6 2 7 4.5 COC1(OC)CCN(c2nc(Nc3ccc(Cl)cc3)c3[nH]c(C(C)C)nc3n2)CC1 10.1016/0960-894X(95)00502-K
44329484 214747 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 344 6 3 5 4.7 CCCNc1nc(Nc2ccc(Cl)cc2)c2[nH]c(C(C)C)nc2n1 10.1016/0960-894X(95)00502-K
CHEMBL97140 214747 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 344 6 3 5 4.7 CCCNc1nc(Nc2ccc(Cl)cc2)c2[nH]c(C(C)C)nc2n1 10.1016/0960-894X(95)00502-K
44281572 117169 0 None -1 2 Human 7.5 pKi = 7.5 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 705 10 2 6 8.7 CO/N=C(\COC(=O)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32431 117169 0 None -1 2 Human 7.5 pKi = 7.5 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 705 10 2 6 8.7 CO/N=C(\COC(=O)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
9874473 48582 0 None -16 3 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligandIn vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
CHEMBL149326 48582 0 None -16 3 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligandIn vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
9852904 123815 0 None -128 3 Human 7.5 pKi = 7.5 Binding
Inhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cellsInhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cells
ChEMBL 677 10 1 6 5.9 CNC(=O)C1(N2CCCCC2=O)CCN(CC[C@H](CN(C)C(=O)c2c(OC)c(C#N)cc3ccccc23)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm020094i
CHEMBL339051 123815 0 None -128 3 Human 7.5 pKi = 7.5 Binding
Inhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cellsInhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cells
ChEMBL 677 10 1 6 5.9 CNC(=O)C1(N2CCCCC2=O)CCN(CC[C@H](CN(C)C(=O)c2c(OC)c(C#N)cc3ccccc23)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm020094i
2110 9743 38 None -138 6 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cellsDisplacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cells
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm900948q
219077 9743 38 None -138 6 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cellsDisplacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cells
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm900948q
3480 9743 38 None -138 6 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cellsDisplacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cells
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm900948q
CHEMBL346178 9743 38 None -138 6 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cellsDisplacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cells
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm900948q
DB04872 9743 38 None -138 6 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cellsDisplacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cells
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm900948q
44380474 65557 0 None -13 2 Human 6.5 pKi = 6.5 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 678 12 2 5 8.2 CONC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL168769 65557 0 None -13 2 Human 6.5 pKi = 6.5 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 678 12 2 5 8.2 CONC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44314481 211715 0 None -10 2 Human 6.5 pKi = 6.5 Binding
Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand
ChEMBL 662 10 2 5 8.5 O/N=C(/COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL76334 211715 0 None -10 2 Human 6.5 pKi = 6.5 Binding
Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand
ChEMBL 662 10 2 5 8.5 O/N=C(/COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
86275686 153944 0 None -851 2 Human 4.4 pKi = 4.4 Binding
Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 392 2 0 7 3.1 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(F)c2)C3C)n1 nan
CHEMBL3927872 153944 0 None -851 2 Human 4.4 pKi = 4.4 Binding
Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 392 2 0 7 3.1 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(F)c2)C3C)n1 nan
86274728 167735 0 None -1380 2 Human 4.4 pKi = 4.4 Binding
Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 394 2 0 7 2.7 Cc1nsc(-c2nnc3n2CCN(C(=O)c2cc(F)c(F)c(F)c2)[C@@H]3C)n1 nan
CHEMBL4115594 167735 0 None -1380 2 Human 4.4 pKi = 4.4 Binding
Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 394 2 0 7 2.7 Cc1nsc(-c2nnc3n2CCN(C(=O)c2cc(F)c(F)c(F)c2)[C@@H]3C)n1 nan
44314865 211892 0 None -3 2 Human 6.4 pKi = 6.4 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 738 13 0 6 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N(C)C2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL77752 211892 0 None -3 2 Human 6.4 pKi = 6.4 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 738 13 0 6 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N(C)C2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
9874473 48582 0 None -16 3 Human 7.4 pKi = 7.4 Binding
In vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligandIn vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
CHEMBL149326 48582 0 None -16 3 Human 7.4 pKi = 7.4 Binding
In vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligandIn vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
2132 10516 58 None -97 6 Human 5.4 pKi = 5.4 Binding
Binding affinity to human NK2 receptor by radioligand binding assayBinding affinity to human NK2 receptor by radioligand binding assay
ChEMBL 382 5 2 3 5.5 CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1 10.1016/j.bmcl.2011.02.033
5311424 10516 58 None -97 6 Human 5.4 pKi = 5.4 Binding
Binding affinity to human NK2 receptor by radioligand binding assayBinding affinity to human NK2 receptor by radioligand binding assay
ChEMBL 382 5 2 3 5.5 CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1 10.1016/j.bmcl.2011.02.033
CHEMBL10188 10516 58 None -97 6 Human 5.4 pKi = 5.4 Binding
Binding affinity to human NK2 receptor by radioligand binding assayBinding affinity to human NK2 receptor by radioligand binding assay
ChEMBL 382 5 2 3 5.5 CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1 10.1016/j.bmcl.2011.02.033
2089 9542 28 None -3548 5 Guinea pig 5.4 pKi = 5.4 Binding
Evaluated for the binding affinity against NK2 receptorEvaluated for the binding affinity against NK2 receptor
ChEMBL None None None None 10.1021/jm00073a022
3795 9542 28 None -3548 5 Guinea pig 5.4 pKi = 5.4 Binding
Evaluated for the binding affinity against NK2 receptorEvaluated for the binding affinity against NK2 receptor
ChEMBL None None None None 10.1021/jm00073a022
5311311 9542 28 None -3548 5 Guinea pig 5.4 pKi = 5.4 Binding
Evaluated for the binding affinity against NK2 receptorEvaluated for the binding affinity against NK2 receptor
ChEMBL None None None None 10.1021/jm00073a022
CHEMBL217406 9542 28 None -3548 5 Guinea pig 5.4 pKi = 5.4 Binding
Evaluated for the binding affinity against NK2 receptorEvaluated for the binding affinity against NK2 receptor
ChEMBL None None None None 10.1021/jm00073a022
86274964 167126 0 None -758 2 Human 4.4 pKi = 4.4 Binding
Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 374 2 0 7 3.0 Cc1nsc(-c2nnc3n2CCN(C(=O)c2cccc(Cl)c2)[C@@H]3C)n1 nan
CHEMBL4110770 167126 0 None -758 2 Human 4.4 pKi = 4.4 Binding
Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 374 2 0 7 3.0 Cc1nsc(-c2nnc3n2CCN(C(=O)c2cccc(Cl)c2)[C@@H]3C)n1 nan
44281485 122036 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 616 12 1 5 8.3 CO/N=C(\COCc1ccc(-c2ccccc2)cc1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33479 122036 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 616 12 1 5 8.3 CO/N=C(\COCc1ccc(-c2ccccc2)cc1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44314873 211569 0 None -2 2 Human 7.4 pKi = 7.4 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 726 12 1 7 6.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL74918 211569 0 None -2 2 Human 7.4 pKi = 7.4 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 726 12 1 7 6.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
73351579 96180 0 None 2 2 Human 5.4 pKi = 5.4 Binding
Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)
ChEMBL 800 7 9 9 0.1 CC(C)=CCc1cc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)ccc1O 10.1021/jm00029a007
CHEMBL2370507 96180 0 None 2 2 Human 5.4 pKi = 5.4 Binding
Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)
ChEMBL 800 7 9 9 0.1 CC(C)=CCc1cc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)ccc1O 10.1021/jm00029a007
44314945 211775 0 None -9 2 Human 6.4 pKi = 6.4 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 728 17 1 7 6.9 CCOCCCNC(=O)CN1CCN(CCC(/C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)=N/OC)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(00)00464-9
CHEMBL76727 211775 0 None -9 2 Human 6.4 pKi = 6.4 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 728 17 1 7 6.9 CCOCCCNC(=O)CN1CCN(CCC(/C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)=N/OC)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(00)00464-9
44363982 42440 0 None -2 2 Human 7.4 pKi = 7.4 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 683 12 0 6 7.8 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCOCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL144010 42440 0 None -2 2 Human 7.4 pKi = 7.4 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 683 12 0 6 7.8 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCOCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44364030 43421 0 None 1 2 Human 7.4 pKi = 7.4 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 711 13 1 6 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(CO)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL144887 43421 0 None 1 2 Human 7.4 pKi = 7.4 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 711 13 1 6 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(CO)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44434164 173831 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 562 13 3 5 4.9 CCN(CC)CCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
CHEMBL428905 173831 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 562 13 3 5 4.9 CCN(CC)CCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
44380473 127562 0 None -549 2 Human 6.4 pKi = 6.4 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 684 12 1 6 6.5 CN(C/C(=N\OCC(=O)O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL355429 127562 0 None -549 2 Human 6.4 pKi = 6.4 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 684 12 1 6 6.5 CN(C/C(=N\OCC(=O)O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44314476 111859 0 None -12 2 Human 6.4 pKi = 6.4 Binding
Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL311387 111859 0 None -12 2 Human 6.4 pKi = 6.4 Binding
Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
44434166 95527 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 534 12 4 5 4.3 NCCCCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
CHEMBL236248 95527 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 534 12 4 5 4.3 NCCCCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
90663623 113487 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 628 15 4 7 3.4 NCCOCCOCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCc2ccccc2C1 10.1016/j.bmcl.2007.06.053
CHEMBL3143849 113487 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 628 15 4 7 3.4 NCCOCCOCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCc2ccccc2C1 10.1016/j.bmcl.2007.06.053
CHEMBL117039 215340 0 None - 1 Human 6.4 pKi = 6.4 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL None None None O=C1C[C@@H](C(=O)O)NC(=O)[C@@H](Cc2ccc(Cl)c(Cl)c2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm011127h
2132 10516 58 None -97 6 Human 5.4 pKi = 5.4 Binding
Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysisDisplacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysis
ChEMBL 382 5 2 3 5.5 CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1 10.1021/jm5017413
5311424 10516 58 None -97 6 Human 5.4 pKi = 5.4 Binding
Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysisDisplacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysis
ChEMBL 382 5 2 3 5.5 CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1 10.1021/jm5017413
CHEMBL10188 10516 58 None -97 6 Human 5.4 pKi = 5.4 Binding
Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysisDisplacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysis
ChEMBL 382 5 2 3 5.5 CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1 10.1021/jm5017413
10875000 170651 0 None - 1 Human 5.4 pKi = 5.4 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 518 5 6 5 -0.2 NC(=O)[C@@H]1CNC(=O)CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1 10.1021/jm011127h
CHEMBL420685 170651 0 None - 1 Human 5.4 pKi = 5.4 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 518 5 6 5 -0.2 NC(=O)[C@@H]1CNC(=O)CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1 10.1021/jm011127h
44315210 109695 0 None -1 3 Human 8.4 pKi = 8.4 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 747 14 0 8 8.0 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CCOC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL306124 109695 0 None -1 3 Human 8.4 pKi = 8.4 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 747 14 0 8 8.0 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CCOC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
44281723 106403 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 596 11 1 5 8.0 CO/N=C(\COCc1ccc(C(C)(C)C)cc1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL284145 106403 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 596 11 1 5 8.0 CO/N=C(\COCc1ccc(C(C)(C)C)cc1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281666 115982 0 None -1 2 Human 8.4 pKi = 8.4 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 635 10 1 5 7.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32163 115982 0 None -1 2 Human 8.4 pKi = 8.4 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 635 10 1 5 7.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281958 116464 0 None 1 2 Human 8.4 pKi = 8.4 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 646 10 1 6 6.4 CO/N=C(\CN(C)C(=O)c1cncc(Br)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32273 116464 0 None 1 2 Human 8.4 pKi = 8.4 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 646 10 1 6 6.4 CO/N=C(\CN(C)C(=O)c1cncc(Br)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281787 169978 0 None 14 2 Human 8.4 pKi = 8.4 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 597 11 1 6 6.2 CO/N=C(\CN(C)C(=O)c1ccccc1OC)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL418224 169978 0 None 14 2 Human 8.4 pKi = 8.4 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 597 11 1 6 6.2 CO/N=C(\CN(C)C(=O)c1ccccc1OC)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44363908 42557 0 None 4 2 Human 8.4 pKi = 8.4 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 681 11 0 5 8.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL144116 42557 0 None 4 2 Human 8.4 pKi = 8.4 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 681 11 0 5 8.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44315589 211617 0 None -2 3 Human 8.4 pKi = 8.4 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 804 16 1 9 7.2 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(=O)NCCOC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL75478 211617 0 None -2 3 Human 8.4 pKi = 8.4 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 804 16 1 9 7.2 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(=O)NCCOC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
44315589 211617 0 None -2 3 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]NKA from human NK2 receptor expressed in CHO cells membranesDisplacement of [3H]NKA from human NK2 receptor expressed in CHO cells membranes
ChEMBL 804 16 1 9 7.2 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(=O)NCCOC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1021/acs.jmedchem.9b00017
CHEMBL75478 211617 0 None -2 3 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]NKA from human NK2 receptor expressed in CHO cells membranesDisplacement of [3H]NKA from human NK2 receptor expressed in CHO cells membranes
ChEMBL 804 16 1 9 7.2 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(=O)NCCOC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1021/acs.jmedchem.9b00017
23625634 99356 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 567 12 4 6 3.4 CSc1ccc(NC(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)CCCC2)cc1 10.1021/jm070289w
CHEMBL243503 99356 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 567 12 4 6 3.4 CSc1ccc(NC(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)CCCC2)cc1 10.1021/jm070289w
44380414 64929 0 None -3 2 Human 8.4 pKi = 8.4 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 699 12 2 7 5.9 CN(C/C(=N\OCC(=O)NO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL167994 64929 0 None -3 2 Human 8.4 pKi = 8.4 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 699 12 2 7 5.9 CN(C/C(=N\OCC(=O)NO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
9956370 180501 0 None 53 3 Human 8.4 pKi = 8.4 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 470 6 1 4 5.5 CC(C)N1CCN(Cc2c(-c3ccccc3)nc3ccccc3c2C(=O)NC2CCCCC2)CC1 10.1021/jm000501v
CHEMBL45362 180501 0 None 53 3 Human 8.4 pKi = 8.4 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 470 6 1 4 5.5 CC(C)N1CCN(Cc2c(-c3ccccc3)nc3ccccc3c2C(=O)NC2CCCCC2)CC1 10.1021/jm000501v
44380279 64593 0 None -3 2 Human 8.4 pKi = 8.4 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 761 15 1 7 6.3 CN(C/C(=N\OCCCNS(C)(=O)=O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL166975 64593 0 None -3 2 Human 8.4 pKi = 8.4 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 761 15 1 7 6.3 CN(C/C(=N\OCCCNS(C)(=O)=O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
49863732 22103 0 None -24 4 Rat 8.4 pKi = 8.4 Binding
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 1266 18 10 12 6.1 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
CHEMBL1214025 22103 0 None -24 4 Rat 8.4 pKi = 8.4 Binding
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 1266 18 10 12 6.1 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
53325456 65260 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins
ChEMBL 630 14 3 5 5.1 CCCCc1ccc(C(=O)NC2(C(=O)N[C@@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2011.01.074
CHEMBL1683149 65260 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins
ChEMBL 630 14 3 5 5.1 CCCCc1ccc(C(=O)NC2(C(=O)N[C@@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2011.01.074
11800732 187375 0 None -3 3 Human 8.3 pKi = 8.3 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 546 8 1 4 7.2 CC[C@H](NC(=O)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm000501v
CHEMBL47544 187375 0 None -3 3 Human 8.3 pKi = 8.3 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 546 8 1 4 7.2 CC[C@H](NC(=O)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm000501v
23626411 99006 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 673 12 3 7 3.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCC(=O)N2CCC(N3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
CHEMBL242624 99006 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 673 12 3 7 3.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCC(=O)N2CCC(N3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
10392319 202978 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 532 12 1 3 7.3 CCCC(O)(CCC)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
CHEMBL56143 202978 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 532 12 1 3 7.3 CCCC(O)(CCC)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
44315591 211753 0 None -1 3 Human 8.3 pKi = 8.3 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 746 13 1 8 6.9 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(N)=O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL76529 211753 0 None -1 3 Human 8.3 pKi = 8.3 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 746 13 1 8 6.9 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(N)=O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
44380337 64209 0 None -6 2 Human 8.3 pKi = 8.3 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 735 14 0 8 7.1 CN(C/C(=N\OCCCn1cncn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL165465 64209 0 None -6 2 Human 8.3 pKi = 8.3 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 735 14 0 8 7.1 CN(C/C(=N\OCCCn1cncn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
23626254 99996 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 594 16 6 7 2.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCNC(CCO)CCO)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
CHEMBL244766 99996 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 594 16 6 7 2.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCNC(CCO)CCO)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
10280686 149855 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 546 11 3 6 3.0 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2ccccc2o1 10.1021/jm070289w
CHEMBL389525 149855 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 546 11 3 6 3.0 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2ccccc2o1 10.1021/jm070289w
44315573 110573 0 None -1 3 Human 8.3 pKi = 8.3 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 707 12 1 7 8.3 CO/N=C(\CN(CCF)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL308983 110573 0 None -1 3 Human 8.3 pKi = 8.3 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 707 12 1 7 8.3 CO/N=C(\CN(CCF)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
10145229 15945 0 None -2 4 Human 8.3 pKi = 8.3 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL110219 15945 0 None -2 4 Human 8.3 pKi = 8.3 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44281726 116305 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 540 11 1 5 6.7 CO/N=C(\COCc1ccccc1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32215 116305 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 540 11 1 5 6.7 CO/N=C(\COCc1ccccc1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
22405761 205068 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 504 10 0 4 5.9 CC(=O)OCCC1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
CHEMBL57589 205068 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 504 10 0 4 5.9 CC(=O)OCCC1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
2110 9743 38 None -138 6 Human 7.4 pKi = 7.4 Binding
Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm9602423
219077 9743 38 None -138 6 Human 7.4 pKi = 7.4 Binding
Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm9602423
3480 9743 38 None -138 6 Human 7.4 pKi = 7.4 Binding
Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm9602423
CHEMBL346178 9743 38 None -138 6 Human 7.4 pKi = 7.4 Binding
Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm9602423
DB04872 9743 38 None -138 6 Human 7.4 pKi = 7.4 Binding
Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm9602423
44312828 111137 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 640 12 0 8 6.1 CC1=C(C(=O)Oc2ccccc2)[S+]([O-])C2C(O1)OC(COCc1ccccc1)C(OCc1ccccc1)C2OCc1ccccc1 10.1016/s0960-894x(02)00471-7
CHEMBL310084 111137 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 640 12 0 8 6.1 CC1=C(C(=O)Oc2ccccc2)[S+]([O-])C2C(O1)OC(COCc1ccccc1)C(OCc1ccccc1)C2OCc1ccccc1 10.1016/s0960-894x(02)00471-7
44312485 211418 0 None - 1 Human 5.4 pKi = 5.4 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 486 9 1 8 3.8 CCOC(=O)C1=C(C)OC2OC(CO)C(OCc3ccccc3)C(OCc3ccccc3)C2S1 10.1016/s0960-894x(02)00471-7
CHEMBL73540 211418 0 None - 1 Human 5.4 pKi = 5.4 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 486 9 1 8 3.8 CCOC(=O)C1=C(C)OC2OC(CO)C(OCc3ccccc3)C(OCc3ccccc3)C2S1 10.1016/s0960-894x(02)00471-7
44312718 211564 0 None - 1 Human 5.4 pKi = 5.4 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 502 9 1 8 2.8 CCOC(=O)C1=C(C)OC2OC(CO)C(OCc3ccccc3)C(OCc3ccccc3)C2[S+]1[O-] 10.1016/s0960-894x(02)00471-7
CHEMBL74882 211564 0 None - 1 Human 5.4 pKi = 5.4 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 502 9 1 8 2.8 CCOC(=O)C1=C(C)OC2OC(CO)C(OCc3ccccc3)C(OCc3ccccc3)C2[S+]1[O-] 10.1016/s0960-894x(02)00471-7
44314577 166659 0 None -16 2 Human 6.4 pKi = 6.4 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 782 14 0 8 7.1 CCOC(=O)C1CCN(C(=O)CN2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/s0960-894x(00)00464-9
CHEMBL41068 166659 0 None -16 2 Human 6.4 pKi = 6.4 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 782 14 0 8 7.1 CCOC(=O)C1CCN(C(=O)CN2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/s0960-894x(00)00464-9
CHEMBL4521971 220757 45 None -338 5 Human 5.4 pKi = 5.4 Binding
Selectivity interaction (CEREP panel (GPCRS, ion channels, transporters)) EUB0000193b TACR2Selectivity interaction (CEREP panel (GPCRS, ion channels, transporters)) EUB0000193b TACR2
ChEMBL None None None Clc1cc2c(NC3CCCC3)nnc(-c3ccncc3)c2cc1Cl 10.6019/CHEMBL5212743
2750 210840 76 None -2 12 Human 5.4 pKi = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 333 5 1 4 3.9 CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1 nan
CHEMBL7002 210840 76 None -2 12 Human 5.4 pKi = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 333 5 1 4 3.9 CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1 nan
44380596 66126 0 None 1 2 Human 7.4 pKi = 7.4 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 706 13 1 6 8.7 COCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL170727 66126 0 None 1 2 Human 7.4 pKi = 7.4 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 706 13 1 6 8.7 COCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44281505 123668 0 None 2 2 Human 7.4 pKi = 7.4 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 576 11 1 5 6.9 CO/N=C(\COCc1cc(F)cc(F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33833 123668 0 None 2 2 Human 7.4 pKi = 7.4 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 576 11 1 5 6.9 CO/N=C(\COCc1cc(F)cc(F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
2090 9543 25 None -38 4 Human 7.4 pKi = 7.4 Binding
The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
5311312 9543 25 None -38 4 Human 7.4 pKi = 7.4 Binding
The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
CHEMBL437797 9543 25 None -38 4 Human 7.4 pKi = 7.4 Binding
The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
9940831 21418 0 None -912 4 Human 5.4 pKi = 5.4 Binding
Binding affinity for NK-2 receptor was determined in a radioligand binding assay using chinese hamster ovary cells.Binding affinity for NK-2 receptor was determined in a radioligand binding assay using chinese hamster ovary cells.
ChEMBL 810 13 4 9 5.7 O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL1205204 21418 0 None -912 4 Human 5.4 pKi = 5.4 Binding
Binding affinity for NK-2 receptor was determined in a radioligand binding assay using chinese hamster ovary cells.Binding affinity for NK-2 receptor was determined in a radioligand binding assay using chinese hamster ovary cells.
ChEMBL 810 13 4 9 5.7 O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL65468 21418 0 None -912 4 Human 5.4 pKi = 5.4 Binding
Binding affinity for NK-2 receptor was determined in a radioligand binding assay using chinese hamster ovary cells.Binding affinity for NK-2 receptor was determined in a radioligand binding assay using chinese hamster ovary cells.
ChEMBL 810 13 4 9 5.7 O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
44281334 126172 0 None 2 2 Human 7.4 pKi = 7.4 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 541 11 1 6 6.1 CO/N=C(\COCc1ccccn1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL34460 126172 0 None 2 2 Human 7.4 pKi = 7.4 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 541 11 1 6 6.1 CO/N=C(\COCc1ccccn1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44329530 119182 0 None - 1 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 428 4 2 7 4.2 CC(C)c1nc2[nH]c(N3CCC4(CC3)OCCO4)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
CHEMBL329749 119182 0 None - 1 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 428 4 2 7 4.2 CC(C)c1nc2[nH]c(N3CCC4(CC3)OCCO4)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
CHEMBL103634 215237 0 None - 1 Human 7.4 pKi = 7.4 Binding
The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2
ChEMBL None None None CC(C)CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(C)C)C(N)=O 10.1021/jm9807151
52918299 65265 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins
ChEMBL 640 13 2 6 5.4 COc1c(C(=O)NC2(C(=O)N[C@H](CCCN3CCN(CC4CCOCC4)CC3)Cc3ccccc3)CCCC2)ccc2ccccc12 10.1016/j.bmcl.2011.01.074
CHEMBL1683154 65265 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins
ChEMBL 640 13 2 6 5.4 COc1c(C(=O)NC2(C(=O)N[C@H](CCCN3CCN(CC4CCOCC4)CC3)Cc3ccccc3)CCCC2)ccc2ccccc12 10.1016/j.bmcl.2011.01.074
44380093 127514 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 733 13 2 6 7.8 CNC(=O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL354892 127514 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 733 13 2 6 7.8 CNC(=O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
11734825 19999 0 None -549 2 Human 6.3 pKi = 6.3 Binding
In vitro binding affinity towards Human Tachykinin receptor 2In vitro binding affinity towards Human Tachykinin receptor 2
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
CHEMBL119126 19999 0 None -549 2 Human 6.3 pKi = 6.3 Binding
In vitro binding affinity towards Human Tachykinin receptor 2In vitro binding affinity towards Human Tachykinin receptor 2
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
44363978 47264 0 None -1 2 Human 7.3 pKi = 7.3 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 697 12 1 6 7.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL148282 47264 0 None -1 2 Human 7.3 pKi = 7.3 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 697 12 1 6 7.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
22405743 107473 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 462 9 1 3 5.3 CN(CC(CCN1CCC(CCO)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(98)00037-7
CHEMBL292415 107473 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 462 9 1 3 5.3 CN(CC(CCN1CCC(CCO)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(98)00037-7
44314732 211873 0 None -3 2 Human 6.3 pKi = 6.3 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 764 12 0 6 8.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCC3CCCCC32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL77592 211873 0 None -3 2 Human 6.3 pKi = 6.3 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 764 12 0 6 8.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCC3CCCCC32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44380413 103371 0 None -21 2 Human 7.3 pKi = 7.3 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 741 15 1 7 6.2 COCCNC(=O)CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL263214 103371 0 None -21 2 Human 7.3 pKi = 7.3 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 741 15 1 7 6.2 COCCNC(=O)CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44314487 109690 0 None -5 2 Human 7.3 pKi = 7.3 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 753 13 1 7 6.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC(NC(C)=O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL306097 109690 0 None -5 2 Human 7.3 pKi = 7.3 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 753 13 1 7 6.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC(NC(C)=O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
6518171 175075 55 None -4 8 Human 5.3 pKi = 5.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 495 12 2 6 4.9 CN(CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(=O)O)cc1)c1ccccn1 nan
CHEMBL434063 175075 55 None -4 8 Human 5.3 pKi = 5.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 495 12 2 6 4.9 CN(CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(=O)O)cc1)c1ccccn1 nan
86274731 167452 0 None -1584 2 Human 4.3 pKi = 4.3 Binding
Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 412 2 0 7 2.9 Cc1nsc(-c2nnc3n2CCN(C(=O)c2cc(F)c(F)c(F)c2F)[C@@H]3C)n1 nan
CHEMBL4113428 167452 0 None -1584 2 Human 4.3 pKi = 4.3 Binding
Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 412 2 0 7 2.9 Cc1nsc(-c2nnc3n2CCN(C(=O)c2cc(F)c(F)c(F)c2F)[C@@H]3C)n1 nan
3561 25849 39 None -1 11 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 360 2 0 1 4.4 Clc1cc(Cl)c(OCC#CI)cc1Cl nan
CHEMBL1289 25849 39 None -1 11 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 360 2 0 1 4.4 Clc1cc(Cl)c(OCC#CI)cc1Cl nan
71461646 85684 0 None -2 2 Human 8.3 pKi = 8.3 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 676 11 0 5 7.6 CN(C/C(=N\OC(F)F)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL2112941 85684 0 None -2 2 Human 8.3 pKi = 8.3 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 676 11 0 5 7.6 CN(C/C(=N\OC(F)F)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL2390989 217190 16 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity to human NK2 receptor by radioligand displacement assayBinding affinity to human NK2 receptor by radioligand displacement assay
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(N)=O 10.1016/j.ejmech.2013.01.044
10390024 24726 0 None - 1 Rat 8.3 pKi = 8.3 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 471 5 1 5 3.8 Cc1ccc(S(=O)(=O)N2CC3(CCN(CCc4c[nH]c5ccc(F)cc45)CC3)OC2=O)cc1 10.1021/jm00019a006
CHEMBL126043 24726 0 None - 1 Rat 8.3 pKi = 8.3 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 471 5 1 5 3.8 Cc1ccc(S(=O)(=O)N2CC3(CCN(CCc4c[nH]c5ccc(F)cc45)CC3)OC2=O)cc1 10.1021/jm00019a006
44577886 178704 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 632 14 3 6 4.5 CCCOc1cccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)c1 10.1016/j.bmcl.2008.06.102
CHEMBL447011 178704 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 632 14 3 6 4.5 CCCOc1cccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)c1 10.1016/j.bmcl.2008.06.102
44577895 195652 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 630 14 3 5 5.1 CCCCc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
CHEMBL507077 195652 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 630 14 3 5 5.1 CCCCc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
44374543 59669 0 None -1 2 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 773 9 5 6 3.7 O=C1C[C@H](CC(=O)N2CCC(N3CCCCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
CHEMBL159585 59669 0 None -1 2 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 773 9 5 6 3.7 O=C1C[C@H](CC(=O)N2CCC(N3CCCCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
11251301 149744 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 663 7 6 6 2.0 NC1CCN([C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
CHEMBL389432 149744 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 663 7 6 6 2.0 NC1CCN([C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
44343033 16582 0 None - 1 Human 8.3 pKi = 8.3 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 685 9 4 5 5.4 O=C(N[C@H]1CCCCN(Cc2ccccc2)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O)OCc1ccccc1 10.1021/jm011127h
CHEMBL113765 16582 0 None - 1 Human 8.3 pKi = 8.3 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 685 9 4 5 5.4 O=C(N[C@H]1CCCCN(Cc2ccccc2)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O)OCc1ccccc1 10.1021/jm011127h
44315422 109916 0 None -2 3 Human 8.3 pKi = 8.3 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 747 13 1 8 7.5 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(=O)O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL307877 109916 0 None -2 3 Human 8.3 pKi = 8.3 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 747 13 1 8 7.5 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(=O)O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
9940831 21418 0 None -1 4 Rabbit 8.3 pKi = 8.3 Binding
Binding affinity for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.Binding affinity for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.
ChEMBL 810 13 4 9 5.7 O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL1205204 21418 0 None -1 4 Rabbit 8.3 pKi = 8.3 Binding
Binding affinity for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.Binding affinity for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.
ChEMBL 810 13 4 9 5.7 O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL65468 21418 0 None -1 4 Rabbit 8.3 pKi = 8.3 Binding
Binding affinity for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.Binding affinity for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.
ChEMBL 810 13 4 9 5.7 O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
44380248 64937 0 None -1 2 Human 8.3 pKi = 8.3 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 720 13 0 7 7.3 CN(C/C(=N\OCCn1ccnc1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL168144 64937 0 None -1 2 Human 8.3 pKi = 8.3 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 720 13 0 7 7.3 CN(C/C(=N\OCCn1ccnc1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
10303126 159963 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 560 11 3 6 3.3 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CC=CC1)c1cc2ccccc2s1 10.1021/jm070289w
CHEMBL397702 159963 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 560 11 3 6 3.3 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CC=CC1)c1cc2ccccc2s1 10.1021/jm070289w
44305818 21567 0 None -1 4 Rabbit 8.3 pKi = 8.3 Binding
Binding affinity for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.Binding affinity for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.
ChEMBL 698 13 3 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL1206764 21567 0 None -1 4 Rabbit 8.3 pKi = 8.3 Binding
Binding affinity for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.Binding affinity for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.
ChEMBL 698 13 3 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL305119 21567 0 None -1 4 Rabbit 8.3 pKi = 8.3 Binding
Binding affinity for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.Binding affinity for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.
ChEMBL 698 13 3 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
10696939 188377 0 None -3 3 Human 8.2 pKi = 8.2 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 506 8 1 4 6.3 CC[C@H](NC(=O)c1c(CN2CCN(C(C)C)CC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm000501v
CHEMBL47713 188377 0 None -3 3 Human 8.2 pKi = 8.2 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 506 8 1 4 6.3 CC[C@H](NC(=O)c1c(CN2CCN(C(C)C)CC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm000501v
118724122 123189 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
ChEMBL 1296 40 16 22 -3.0 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1cnc[nH]1)Nc1ccc([N+](=O)[O-])c2nonc12)[C@@H](C)O)C(C)C)C(N)=O 10.1021/jm401823z
CHEMBL3360201 123189 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
ChEMBL 1296 40 16 22 -3.0 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1cnc[nH]1)Nc1ccc([N+](=O)[O-])c2nonc12)[C@@H](C)O)C(C)C)C(N)=O 10.1021/jm401823z
44380081 64882 0 None -100 2 Human 7.3 pKi = 7.3 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 738 13 1 7 6.3 CN(C/C(=N\OCCN1CCNCC1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL167546 64882 0 None -100 2 Human 7.3 pKi = 7.3 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 738 13 1 7 6.3 CN(C/C(=N\OCCN1CCNCC1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44380733 65390 0 None -7 2 Human 7.3 pKi = 7.3 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 720 14 1 6 8.7 COCCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL168437 65390 0 None -7 2 Human 7.3 pKi = 7.3 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 720 14 1 6 8.7 COCCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44390607 70678 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 558 11 3 5 5.3 CC(C)(C)c1ccc(Oc2ccc(NC(=O)N[C@@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc1 10.1016/j.bmcl.2004.11.045
CHEMBL180539 70678 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 558 11 3 5 5.3 CC(C)(C)c1ccc(Oc2ccc(NC(=O)N[C@@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc1 10.1016/j.bmcl.2004.11.045
44384147 137471 0 None - 1 Rat 7.3 pKi = 7.3 Binding
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 524 9 1 3 6.3 CN(CC(CCN1CCC(CO)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/S0960-894X(00)80694-0
CHEMBL368372 137471 0 None - 1 Rat 7.3 pKi = 7.3 Binding
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 524 9 1 3 6.3 CN(CC(CCN1CCC(CO)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/S0960-894X(00)80694-0
44434188 96381 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 574 11 3 5 5.1 CN1CCCC1CCCNC(=O)C(Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
CHEMBL237517 96381 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 574 11 3 5 5.1 CN1CCCC1CCCNC(=O)C(Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
44434161 97036 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 562 11 4 5 4.1 CC(C)C[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1)C(N)=O 10.1016/j.bmcl.2007.06.053
CHEMBL238392 97036 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 562 11 4 5 4.1 CC(C)C[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1)C(N)=O 10.1016/j.bmcl.2007.06.053
44434170 161208 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 566 15 4 7 2.8 NCCOCCOCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCC1 10.1016/j.bmcl.2007.06.053
CHEMBL398982 161208 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 566 15 4 7 2.8 NCCOCCOCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCC1 10.1016/j.bmcl.2007.06.053
44390506 70278 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 552 12 3 5 4.1 O=C(Nc1ccc(OCc2cc(F)cc(F)c2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL179986 70278 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 552 12 3 5 4.1 O=C(Nc1ccc(OCc2cc(F)cc(F)c2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
44391084 71101 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 502 11 3 5 4.1 O=C(Nc1ccc(Oc2ccccc2)cc1)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL181153 71101 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 502 11 3 5 4.1 O=C(Nc1ccc(Oc2ccccc2)cc1)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
44391034 71347 0 None - 1 Human 5.3 pKi = 5.3 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 529 12 2 5 4.1 CC(C)(Oc1ccccc1-c1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL181581 71347 0 None - 1 Human 5.3 pKi = 5.3 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 529 12 2 5 4.1 CC(C)(Oc1ccccc1-c1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
44390534 71626 0 None - 1 Human 5.3 pKi = 5.3 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 584 12 3 5 4.9 O=C(Nc1ccc(OCc2ccc(C(F)(F)F)cc2)cc1)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL182082 71626 0 None - 1 Human 5.3 pKi = 5.3 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 584 12 3 5 4.9 O=C(Nc1ccc(OCc2ccc(C(F)(F)F)cc2)cc1)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
44391022 128802 0 None - 1 Human 5.3 pKi = 5.3 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 502 11 3 5 4.1 O=C(Nc1ccccc1Oc1ccccc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL359487 128802 0 None - 1 Human 5.3 pKi = 5.3 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 502 11 3 5 4.1 O=C(Nc1ccccc1Oc1ccccc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
44331207 174754 0 None - 1 Human 6.3 pKi = 6.3 Binding
Compound was tested for it's binding affinity against human Tachykinin receptor 2Compound was tested for it's binding affinity against human Tachykinin receptor 2
ChEMBL 579 12 3 6 3.8 O=C(NCCc1c[nH]c2ccccc12)c1nccnc1C(=O)N(CCCN1CCOCC1)CCc1c[nH]c2ccccc12 10.1016/s0960-894x(02)00539-5
CHEMBL431838 174754 0 None - 1 Human 6.3 pKi = 6.3 Binding
Compound was tested for it's binding affinity against human Tachykinin receptor 2Compound was tested for it's binding affinity against human Tachykinin receptor 2
ChEMBL 579 12 3 6 3.8 O=C(NCCc1c[nH]c2ccccc12)c1nccnc1C(=O)N(CCCN1CCOCC1)CCc1c[nH]c2ccccc12 10.1016/s0960-894x(02)00539-5
44312406 164122 0 None - 1 Human 5.3 pKi = 5.3 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 702 13 0 8 7.2 O=C(C1=C(c2ccccc2)OC2OC(COCc3ccccc3)C(OCc3ccccc3)C(OCc3ccccc3)C2S1(=O)=O)c1ccccc1 10.1016/s0960-894x(02)00471-7
CHEMBL407769 164122 0 None - 1 Human 5.3 pKi = 5.3 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 702 13 0 8 7.2 O=C(C1=C(c2ccccc2)OC2OC(COCc3ccccc3)C(OCc3ccccc3)C(OCc3ccccc3)C2S1(=O)=O)c1ccccc1 10.1016/s0960-894x(02)00471-7
10717843 107881 0 None -15 2 Human 7.3 pKi = 7.3 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 437 7 1 3 6.1 CC(C)[C@H](NC(=O)c1c(CN(C)C)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm000501v
CHEMBL295059 107881 0 None -15 2 Human 7.3 pKi = 7.3 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 437 7 1 3 6.1 CC(C)[C@H](NC(=O)c1c(CN(C)C)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm000501v
25222441 203920 0 None -104 4 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cellsDisplacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cells
ChEMBL 589 8 0 3 6.4 CC(=O)N(C)C1CCN(CCC(C)(C(=O)N(C)Cc2ccc(F)c(C(F)(F)F)c2)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm900948q
CHEMBL567849 203920 0 None -104 4 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cellsDisplacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cells
ChEMBL 589 8 0 3 6.4 CC(=O)N(C)C1CCN(CCC(C)(C(=O)N(C)Cc2ccc(F)c(C(F)(F)F)c2)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm900948q
44314872 103647 0 None -1 2 Human 7.3 pKi = 7.3 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 740 13 1 7 6.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCCC2CO)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL265499 103647 0 None -1 2 Human 7.3 pKi = 7.3 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 740 13 1 7 6.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCCC2CO)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44329351 214897 0 None 13 2 Golden hamster 6.3 pKi = 6.3 Binding
Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)
ChEMBL 358 4 2 6 3.1 CCc1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
CHEMBL97958 214897 0 None 13 2 Golden hamster 6.3 pKi = 6.3 Binding
Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)
ChEMBL 358 4 2 6 3.1 CCc1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
148124 213878 86 None - 1 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 807 8 5 14 3.3 CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@@H]12)C3(C)C nan
CHEMBL3545252 213878 86 None - 1 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 807 8 5 14 3.3 CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@@H]12)C3(C)C nan
CHEMBL92 213878 86 None - 1 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 807 8 5 14 3.3 CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@@H]12)C3(C)C nan
44363979 127761 0 None -2 2 Human 7.3 pKi = 7.3 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 711 13 1 6 8.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2CO)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL356268 127761 0 None -2 2 Human 7.3 pKi = 7.3 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 711 13 1 6 8.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2CO)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
138106918 202265 42 None - 1 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 778 7 2 11 4.8 CCC1=C[C@@H]2CN(C1)Cc1c([nH]c3ccccc13)[C@@](C(=O)OC)(c1cc3c(cc1OC)N(C)[C@H]1[C@@](O)(C(=O)OC)[C@H](OC(C)=O)[C@]4(CC)C=CCN5CC[C@]31[C@@H]54)C2 nan
5311497 202265 42 None - 1 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 778 7 2 11 4.8 CCC1=C[C@@H]2CN(C1)Cc1c([nH]c3ccccc13)[C@@](C(=O)OC)(c1cc3c(cc1OC)N(C)[C@H]1[C@@](O)(C(=O)OC)[C@H](OC(C)=O)[C@]4(CC)C=CCN5CC[C@]31[C@@H]54)C2 nan
CHEMBL553025 202265 42 None - 1 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 778 7 2 11 4.8 CCC1=C[C@@H]2CN(C1)Cc1c([nH]c3ccccc13)[C@@](C(=O)OC)(c1cc3c(cc1OC)N(C)[C@H]1[C@@](O)(C(=O)OC)[C@H](OC(C)=O)[C@]4(CC)C=CCN5CC[C@]31[C@@H]54)C2 nan
6918276 22383 7 None -56 8 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 559 18 4 9 1.7 CC[C@H](C)[C@@H](CO[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCS(C)(=O)=O)C(=O)OC(C)C)NC[C@@H](N)CS nan
CHEMBL1221512 22383 7 None -56 8 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 559 18 4 9 1.7 CC[C@H](C)[C@@H](CO[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCS(C)(=O)=O)C(=O)OC(C)C)NC[C@@H](N)CS nan
44281788 106762 0 None -1 2 Human 7.3 pKi = 7.3 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 583 11 2 6 5.9 CO/N=C(\CNC(=O)c1ccccc1OC)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL286640 106762 0 None -1 2 Human 7.3 pKi = 7.3 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 583 11 2 6 5.9 CO/N=C(\CNC(=O)c1ccccc1OC)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
10044833 114224 0 None 43 2 Golden hamster 7.3 pKi = 7.3 Binding
Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)
ChEMBL 372 5 2 6 3.5 CCCc1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
CHEMBL318254 114224 0 None 43 2 Golden hamster 7.3 pKi = 7.3 Binding
Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)
ChEMBL 372 5 2 6 3.5 CCCc1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
44329517 215056 0 None -36 2 Human 6.3 pKi = 6.3 Binding
Inhibition constant for displacement of [3H]NKA from the cloned human NK2 receptorInhibition constant for displacement of [3H]NKA from the cloned human NK2 receptor
ChEMBL 387 4 1 6 3.1 CC(C)N1Cc2c(Nc3ccc(Cl)cc3)nc(N3CCOCC3)nc2C1=O 10.1016/0960-894X(95)00502-K
CHEMBL98929 215056 0 None -36 2 Human 6.3 pKi = 6.3 Binding
Inhibition constant for displacement of [3H]NKA from the cloned human NK2 receptorInhibition constant for displacement of [3H]NKA from the cloned human NK2 receptor
ChEMBL 387 4 1 6 3.1 CC(C)N1Cc2c(Nc3ccc(Cl)cc3)nc(N3CCOCC3)nc2C1=O 10.1016/0960-894X(95)00502-K
44329149 114333 0 None - 1 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 392 6 3 5 5.4 CC(C)c1nc2[nH]c(NCc3ccccc3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
CHEMBL318880 114333 0 None - 1 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 392 6 3 5 5.4 CC(C)c1nc2[nH]c(NCc3ccccc3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
11057 182928 23 None -1 20 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 nan
3468 182928 23 None -1 20 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 nan
CHEMBL459265 182928 23 None -1 20 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 nan
CHEMBL64894 182928 23 None -1 20 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 nan
44314454 112394 0 None -4 2 Human 6.3 pKi = 6.3 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 758 12 0 6 7.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCc3ccccc3C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL312295 112394 0 None -4 2 Human 6.3 pKi = 6.3 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 758 12 0 6 7.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCc3ccccc3C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
3823 56995 42 None -36 11 Human 5.2 pKi = 5.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 530 7 0 7 4.2 CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 nan
76973198 56995 42 None -36 11 Human 5.2 pKi = 5.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 530 7 0 7 4.2 CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 nan
CHEMBL157101 56995 42 None -36 11 Human 5.2 pKi = 5.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 530 7 0 7 4.2 CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 nan
44380094 65518 0 None -3 2 Human 7.2 pKi = 7.2 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 719 13 2 6 7.6 NC(=O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL168584 65518 0 None -3 2 Human 7.2 pKi = 7.2 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 719 13 2 6 7.6 NC(=O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44363984 42442 0 None -4 2 Human 7.2 pKi = 7.2 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 735 14 0 5 9.3 C=CCC1CCCN(CC2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(00)00702-2
CHEMBL144011 42442 0 None -4 2 Human 7.2 pKi = 7.2 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 735 14 0 5 9.3 C=CCC1CCCN(CC2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(00)00702-2
15730 77893 80 None -2 10 Human 5.2 pKi = 5.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 206 7 1 1 4.3 CCCCCCCCc1ccc(O)cc1 nan
CHEMBL195437 77893 80 None -2 10 Human 5.2 pKi = 5.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 206 7 1 1 4.3 CCCCCCCCc1ccc(O)cc1 nan
44329367 215027 0 None - 1 Golden hamster 4.2 pKi = 4.2 Binding
Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)
ChEMBL 425 5 2 6 4.0 CC(C)NC(=O)c1ccc2c(Nc3ccc(Cl)cc3)nc(N3CCOCC3)nc2c1 10.1016/0960-894X(95)00502-K
CHEMBL98760 215027 0 None - 1 Golden hamster 4.2 pKi = 4.2 Binding
Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)
ChEMBL 425 5 2 6 4.0 CC(C)NC(=O)c1ccc2c(Nc3ccc(Cl)cc3)nc(N3CCOCC3)nc2c1 10.1016/0960-894X(95)00502-K
44329531 214866 0 None - 1 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 384 4 2 6 4.0 CC(C)c1nc2[nH]c(N3CCC(=O)CC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
CHEMBL97764 214866 0 None - 1 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 384 4 2 6 4.0 CC(C)c1nc2[nH]c(N3CCC(=O)CC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
44364003 125773 0 None -9 2 Human 7.2 pKi = 7.2 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 681 11 0 5 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(C(=O)N2CCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL342572 125773 0 None -9 2 Human 7.2 pKi = 7.2 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 681 11 0 5 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(C(=O)N2CCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44380080 19014 0 None -323 2 Human 6.2 pKi = 6.2 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 726 14 0 5 7.5 CN(C/C(=N\OCCC[N+](C)(C)C)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL1184507 19014 0 None -323 2 Human 6.2 pKi = 6.2 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 726 14 0 5 7.5 CN(C/C(=N\OCCC[N+](C)(C)C)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL352842 19014 0 None -323 2 Human 6.2 pKi = 6.2 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 726 14 0 5 7.5 CN(C/C(=N\OCCC[N+](C)(C)C)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
71549913 125634 0 None -588 3 Human 5.2 pKi = 5.2 Binding
Binding Assay: The affinity of compounds of the invention for the NK2 receptor was evaluated in CHO recombinant cells which express the human NK2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK2 receptor was evaluated in CHO recombinant cells which express the human NK2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 415 3 0 6 4.6 Cc1cccc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)n1 nan
CHEMBL3422007 125634 0 None -588 3 Human 5.2 pKi = 5.2 Binding
Binding Assay: The affinity of compounds of the invention for the NK2 receptor was evaluated in CHO recombinant cells which express the human NK2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK2 receptor was evaluated in CHO recombinant cells which express the human NK2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 415 3 0 6 4.6 Cc1cccc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)n1 nan
44281633 106763 0 None -3 2 Human 8.2 pKi = 8.2 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 664 11 1 7 7.7 CO/N=C(\CN(C)C(=O)c1cc(C)nc(-c2cccs2)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL286646 106763 0 None -3 2 Human 8.2 pKi = 8.2 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 664 11 1 7 7.7 CO/N=C(\CN(C)C(=O)c1cc(C)nc(-c2cccs2)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281778 116473 0 None 4 2 Human 8.2 pKi = 8.2 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 608 11 1 5 8.0 CO/N=C(\COCc1cc(Cl)cc(Cl)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32279 116473 0 None 4 2 Human 8.2 pKi = 8.2 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 608 11 1 5 8.0 CO/N=C(\COCc1cc(Cl)cc(Cl)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281672 120301 0 None 1 2 Human 8.2 pKi = 8.2 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 596 10 1 6 6.2 CO/N=C(\CN(C)C(=O)c1cc(C)nc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33215 120301 0 None 1 2 Human 8.2 pKi = 8.2 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 596 10 1 6 6.2 CO/N=C(\CN(C)C(=O)c1cc(C)nc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
10718673 185886 0 None -1 2 Human 8.2 pKi = 8.2 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 457 6 1 4 5.4 C[C@H](NC(=O)c1c(CN2CCOCC2)c(-c2ccccc2)nc2ccccc12)C1CCCCC1 10.1021/jm000501v
CHEMBL47179 185886 0 None -1 2 Human 8.2 pKi = 8.2 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 457 6 1 4 5.4 C[C@H](NC(=O)c1c(CN2CCOCC2)c(-c2ccccc2)nc2ccccc12)C1CCCCC1 10.1021/jm000501v
10321179 22338 0 None - 1 Rat 8.2 pKi = 8.2 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 443 5 1 3 4.6 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccc(F)cc1F 10.1021/jm00019a006
CHEMBL122019 22338 0 None - 1 Rat 8.2 pKi = 8.2 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 443 5 1 3 4.6 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccc(F)cc1F 10.1021/jm00019a006
10091869 119607 0 None - 1 Rat 8.2 pKi = 8.2 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 391 5 1 2 4.8 Fc1ccc2[nH]cc(CCN3CCC4(CC3)CCN(Cc3ccccc3)C4)c2c1 10.1021/jm00019a006
CHEMBL330766 119607 0 None - 1 Rat 8.2 pKi = 8.2 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 391 5 1 2 4.8 Fc1ccc2[nH]cc(CCN3CCC4(CC3)CCN(Cc3ccccc3)C4)c2c1 10.1021/jm00019a006
44434196 156003 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 594 11 3 5 4.8 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCCC2)CCc2ccccc21)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
CHEMBL394418 156003 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 594 11 3 5 4.8 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCCC2)CCc2ccccc21)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
44434180 159815 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 618 17 3 5 6.5 CCCCN(CCCC)CCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
CHEMBL397576 159815 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 618 17 3 5 6.5 CCCCN(CCCC)CCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
44374557 126373 0 None -1 2 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 693 11 6 6 1.9 CN(C)CCNC(=O)C[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1016/s0960-894x(01)00841-1
CHEMBL346285 126373 0 None -1 2 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 693 11 6 6 1.9 CN(C)CCNC(=O)C[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1016/s0960-894x(01)00841-1
44374622 126841 0 None 1 2 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 825 11 10 10 -0.8 CC(=O)NC1C(NC(=O)C[C@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)OC(CO)C(O)C1O 10.1016/s0960-894x(01)00841-1
CHEMBL350596 126841 0 None 1 2 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 825 11 10 10 -0.8 CC(=O)NC1C(NC(=O)C[C@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)OC(CO)C(O)C1O 10.1016/s0960-894x(01)00841-1
11411718 175726 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 664 8 6 6 2.3 O=C1C[C@H](NC2CCOCC2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1 10.1021/jm040832y
CHEMBL438839 175726 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 664 8 6 6 2.3 O=C1C[C@H](NC2CCOCC2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1 10.1021/jm040832y
44342797 174914 0 None - 1 Human 8.2 pKi = 8.2 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 754 8 10 9 -0.7 O=C1C[C@H](NC(=O)[C@]2(O)C[C@@H](O)[C@@H](O)[C@H](O)C2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm011127h
CHEMBL432986 174914 0 None - 1 Human 8.2 pKi = 8.2 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 754 8 10 9 -0.7 O=C1C[C@H](NC(=O)[C@]2(O)C[C@@H](O)[C@@H](O)[C@H](O)C2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm011127h
44300619 205838 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 503 10 0 4 6.4 CC/C(=N\OC)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
CHEMBL58638 205838 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 503 10 0 4 6.4 CC/C(=N\OC)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
44302496 105189 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligandBinding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligand
ChEMBL 1081 23 8 14 2.5 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)c1ccccc1)C(N)c1ccc([N+](=O)[O-])c2nonc12)C(N)=O 10.1021/jm00039a012
CHEMBL275499 105189 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligandBinding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligand
ChEMBL 1081 23 8 14 2.5 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)c1ccccc1)C(N)c1ccc([N+](=O)[O-])c2nonc12)C(N)=O 10.1021/jm00039a012
44380338 127254 0 None -4 2 Human 8.2 pKi = 8.2 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 734 14 0 7 7.7 CN(C/C(=N\OCCCn1ccnc1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL354196 127254 0 None -4 2 Human 8.2 pKi = 8.2 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 734 14 0 7 7.7 CN(C/C(=N\OCCCn1ccnc1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44391153 71303 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 487 11 2 5 3.1 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL181446 71303 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 487 11 2 5 3.1 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
44390553 176025 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 544 12 3 5 5.2 CC(C)c1ccc(Oc2ccc(NC(=O)N[C@@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc1 10.1016/j.bmcl.2004.11.045
CHEMBL441115 176025 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 544 12 3 5 5.2 CC(C)c1ccc(Oc2ccc(NC(=O)N[C@@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc1 10.1016/j.bmcl.2004.11.045
44434183 174191 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 560 10 3 5 4.7 O=C(NC1(C(=O)NC(Cc2ccccc2)C(=O)NCCN2CCCCC2)CCCCC1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
CHEMBL429631 174191 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 560 10 3 5 4.7 O=C(NC1(C(=O)NC(Cc2ccccc2)C(=O)NCCN2CCCCC2)CCCCC1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
44390532 71219 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 550 12 3 5 4.5 O=C(Nc1ccc(OCc2cccc(Cl)c2)cc1)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL181330 71219 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 550 12 3 5 4.5 O=C(Nc1ccc(OCc2cccc(Cl)c2)cc1)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
44390539 71338 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 530 12 3 5 4.6 CCc1ccc(Oc2ccc(NC(=O)N[C@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc1 10.1016/j.bmcl.2004.11.045
CHEMBL181526 71338 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 530 12 3 5 4.6 CCc1ccc(Oc2ccc(NC(=O)N[C@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc1 10.1016/j.bmcl.2004.11.045
44391105 72402 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 516 12 3 5 3.8 O=C(Nc1ccc(OCc2ccccc2)cc1)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL183414 72402 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 516 12 3 5 3.8 O=C(Nc1ccc(OCc2ccccc2)cc1)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
10603037 123542 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 565 6 5 4 2.4 O=C1CC(Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCN1 10.1021/jm0010217
CHEMBL337628 123542 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 565 6 5 4 2.4 O=C1CC(Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCN1 10.1021/jm0010217
44343099 118105 0 None - 1 Human 6.2 pKi = 6.2 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 567 6 5 4 2.7 O=C1CC(CC2C=CC=CC2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCN1 10.1021/jm011127h
CHEMBL326790 118105 0 None - 1 Human 6.2 pKi = 6.2 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 567 6 5 4 2.7 O=C1CC(CC2C=CC=CC2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCN1 10.1021/jm011127h
44391036 71119 0 None - 1 Human 5.2 pKi = 5.2 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 494 9 3 5 2.1 O=C(NCCCN1CCOCC1)[C@H](Cc1ccccc1)NC(=O)N1CCCC(O)(c2ccccc2)C1 10.1016/j.bmcl.2004.11.045
CHEMBL181225 71119 0 None - 1 Human 5.2 pKi = 5.2 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 494 9 3 5 2.1 O=C(NCCCN1CCOCC1)[C@H](Cc1ccccc1)NC(=O)N1CCCC(O)(c2ccccc2)C1 10.1016/j.bmcl.2004.11.045
44391009 129405 0 None - 1 Human 5.2 pKi = 5.2 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 529 12 2 5 4.1 CC(C)(Oc1cccc(-c2ccccc2)c1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL360354 129405 0 None - 1 Human 5.2 pKi = 5.2 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 529 12 2 5 4.1 CC(C)(Oc1cccc(-c2ccccc2)c1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
2335 18620 22 None -3 12 Human 6.2 pKi = 6.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 nan
8478 18620 22 None -3 12 Human 6.2 pKi = 6.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 nan
CHEMBL1182210 18620 22 None -3 12 Human 6.2 pKi = 6.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 nan
CHEMBL221753 18620 22 None -3 12 Human 6.2 pKi = 6.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 nan
176 7186 66 None -4 31 Human 5.2 pKi = 5.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
2157 7186 66 None -4 31 Human 5.2 pKi = 5.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
2566 7186 66 None -4 31 Human 5.2 pKi = 5.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
CHEMBL633 7186 66 None -4 31 Human 5.2 pKi = 5.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
DB01118 7186 66 None -4 31 Human 5.2 pKi = 5.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
3191 109635 97 None -12 25 Human 6.2 pKi = 6.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 469 9 0 3 7.2 CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 nan
CHEMBL305660 109635 97 None -12 25 Human 6.2 pKi = 6.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 469 9 0 3 7.2 CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 nan
22405753 205574 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 503 10 1 3 5.5 CC(=O)NCCC1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
CHEMBL58331 205574 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 503 10 1 3 5.5 CC(=O)NCCC1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
44329163 118226 0 None 2 2 Golden hamster 5.2 pKi = 5.2 Binding
Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)
ChEMBL 344 3 2 6 2.8 Cc1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
CHEMBL327531 118226 0 None 2 2 Golden hamster 5.2 pKi = 5.2 Binding
Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)
ChEMBL 344 3 2 6 2.8 Cc1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
44363925 46837 0 None -3 2 Human 7.2 pKi = 7.2 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 754 13 1 7 8.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCC(OC(=O)NC(C)C)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL147924 46837 0 None -3 2 Human 7.2 pKi = 7.2 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 754 13 1 7 8.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCC(OC(=O)NC(C)C)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44364002 127826 0 None -8 2 Human 7.2 pKi = 7.2 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 627 11 1 5 6.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(C(N)=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL356796 127826 0 None -8 2 Human 7.2 pKi = 7.2 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 627 11 1 5 6.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(C(N)=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
10022196 215066 0 None 45 2 Golden hamster 7.2 pKi = 7.2 Binding
Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)
ChEMBL 372 4 2 6 3.7 CC(C)c1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
CHEMBL98977 215066 0 None 45 2 Golden hamster 7.2 pKi = 7.2 Binding
Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)
ChEMBL 372 4 2 6 3.7 CC(C)c1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
9809876 26172 1 None -398 3 Human 7.2 pKi = 7.2 Binding
Inhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cellsInhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cells
ChEMBL 661 10 0 5 7.9 COc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm020094i
CHEMBL129321 26172 1 None -398 3 Human 7.2 pKi = 7.2 Binding
Inhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cellsInhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cells
ChEMBL 661 10 0 5 7.9 COc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm020094i
44329351 214897 0 None -13 2 Human 5.2 pKi = 5.2 Binding
Inhibition constant for displacement of [3H]NKA from the cloned human NK2 receptorInhibition constant for displacement of [3H]NKA from the cloned human NK2 receptor
ChEMBL 358 4 2 6 3.1 CCc1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
CHEMBL97958 214897 0 None -13 2 Human 5.2 pKi = 5.2 Binding
Inhibition constant for displacement of [3H]NKA from the cloned human NK2 receptorInhibition constant for displacement of [3H]NKA from the cloned human NK2 receptor
ChEMBL 358 4 2 6 3.1 CCc1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
44337270 115379 0 None 4 2 Human 8.2 pKi = 8.2 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 665 8 3 6 4.5 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)Cc4ccc(O)cc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL320486 115379 0 None 4 2 Human 8.2 pKi = 8.2 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 665 8 3 6 4.5 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)Cc4ccc(O)cc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44281587 60332 0 None 1 2 Human 8.2 pKi = 8.2 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 660 11 1 6 7.4 CO/N=C(\CN(C)C(=O)c1ccc(N(C)C)c2ccccc12)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL160210 60332 0 None 1 2 Human 8.2 pKi = 8.2 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 660 11 1 6 7.4 CO/N=C(\CN(C)C(=O)c1ccc(N(C)C)c2ccccc12)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281342 116208 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 598 11 1 5 7.7 CO/N=C(\COCC12CC3CC(CC(C3)C1)C2)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32201 116208 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 598 11 1 5 7.7 CO/N=C(\COCC12CC3CC(CC(C3)C1)C2)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
10032406 46728 0 None 1 2 Human 8.2 pKi = 8.2 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 667 11 0 5 7.8 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL147824 46728 0 None 1 2 Human 8.2 pKi = 8.2 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 667 11 0 5 7.8 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
10484667 211334 0 None 2 2 Human 8.2 pKi = 8.2 Binding
Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL72930 211334 0 None 2 2 Human 8.2 pKi = 8.2 Binding
Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
25129133 195666 0 None -10 4 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
CHEMBL507340 195666 0 None -10 4 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
44300632 108751 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 476 8 1 3 5.7 CN(CC(CCN1CCC(C(C)(C)O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(98)00037-7
CHEMBL301437 108751 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 476 8 1 3 5.7 CN(CC(CCN1CCC(C(C)(C)O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(98)00037-7
10389401 123877 0 None - 1 Rat 8.1 pKi = 8.1 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 457 5 1 3 5.5 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1cccc2ccccc12 10.1021/jm00019a006
CHEMBL339311 123877 0 None - 1 Rat 8.1 pKi = 8.1 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 457 5 1 3 5.5 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1cccc2ccccc12 10.1021/jm00019a006
9843958 207572 1 None - 1 Rat 8.1 pKi = 8.1 Binding
Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon
ChEMBL 400 6 2 3 3.5 [O-][S+](CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1)c1ccccc1 10.1016/S0960-894X(01)80541-2
CHEMBL60064 207572 1 None - 1 Rat 8.1 pKi = 8.1 Binding
Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon
ChEMBL 400 6 2 3 3.5 [O-][S+](CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1)c1ccccc1 10.1016/S0960-894X(01)80541-2
10627614 17264 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 615 6 5 4 3.7 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc3ccccc3c2)CN1 10.1021/jm0010217
CHEMBL116564 17264 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 615 6 5 4 3.7 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc3ccccc3c2)CN1 10.1021/jm0010217
44434190 156297 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 588 11 3 5 5.4 CC1CCCCN1CCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
CHEMBL394648 156297 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 588 11 3 5 5.4 CC1CCCCN1CCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
44577890 136875 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 632 13 3 6 4.5 CC(C)Oc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
CHEMBL367768 136875 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 632 13 3 6 4.5 CC(C)Oc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
44374504 61623 0 None -1 2 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 825 11 10 10 -0.8 CC(=O)NC1C(NC(=O)C[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)OC(CO)C(O)C1O 10.1016/s0960-894x(01)00841-1
CHEMBL161288 61623 0 None -1 2 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 825 11 10 10 -0.8 CC(=O)NC1C(NC(=O)C[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)OC(CO)C(O)C1O 10.1016/s0960-894x(01)00841-1
11787612 91962 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 664 8 6 6 2.3 O=C1C[C@@H](NC2CCOCC2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1 10.1021/jm040832y
CHEMBL225393 91962 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 664 8 6 6 2.3 O=C1C[C@@H](NC2CCOCC2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1 10.1021/jm040832y
10627614 17264 0 None - 1 Human 8.1 pKi = 8.1 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 615 6 5 4 3.7 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc3ccccc3c2)CN1 10.1021/jm011127h
CHEMBL116564 17264 0 None - 1 Human 8.1 pKi = 8.1 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 615 6 5 4 3.7 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc3ccccc3c2)CN1 10.1021/jm011127h
44343143 117203 0 None - 1 Human 8.1 pKi = 8.1 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 665 10 7 6 1.4 NCCCC(=O)N[C@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1021/jm011127h
CHEMBL324532 117203 0 None - 1 Human 8.1 pKi = 8.1 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 665 10 7 6 1.4 NCCCC(=O)N[C@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1021/jm011127h
9887650 23423 0 None -6 5 Human 8.1 pKi = 8.1 Binding
The compound was tested for binding affinity against Tachykinin receptor 2 from human expressed in CHO cellsThe compound was tested for binding affinity against Tachykinin receptor 2 from human expressed in CHO cells
ChEMBL 407 5 1 3 4.3 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccccc1 10.1021/jm00019a006
CHEMBL124208 23423 0 None -6 5 Human 8.1 pKi = 8.1 Binding
The compound was tested for binding affinity against Tachykinin receptor 2 from human expressed in CHO cellsThe compound was tested for binding affinity against Tachykinin receptor 2 from human expressed in CHO cells
ChEMBL 407 5 1 3 4.3 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccccc1 10.1021/jm00019a006
44434158 96901 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 562 11 4 5 4.1 CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1)C(N)=O 10.1016/j.bmcl.2007.06.053
CHEMBL238181 96901 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 562 11 4 5 4.1 CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1)C(N)=O 10.1016/j.bmcl.2007.06.053
23625636 99596 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 557 11 4 5 3.0 O=C(Nc1ccc(F)c(F)c1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1 10.1021/jm070289w
CHEMBL243726 99596 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 557 11 4 5 3.0 O=C(Nc1ccc(F)c(F)c1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1 10.1021/jm070289w
73347011 96184 0 None -1 2 Human 4.1 pKi = 4.1 Binding
Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)
ChEMBL 730 6 7 8 -0.6 COc1ccc(CC2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)cc1 10.1021/jm00029a007
CHEMBL2370511 96184 0 None -1 2 Human 4.1 pKi = 4.1 Binding
Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)
ChEMBL 730 6 7 8 -0.6 COc1ccc(CC2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)cc1 10.1021/jm00029a007
44314154 211846 0 None -24 2 Human 6.1 pKi = 6.1 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 585 10 1 5 6.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCNCC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL77265 211846 0 None -24 2 Human 6.1 pKi = 6.1 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 585 10 1 5 6.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCNCC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
1212 8443 50 None -389 65 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F nan
204 8443 50 None -389 65 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F nan
3372 8443 50 None -389 65 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F nan
CHEMBL726 8443 50 None -389 65 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F nan
DB00623 8443 50 None -389 65 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F nan
51003494 65096 0 None -9 3 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]NKA from human cloned NK2 receptorDisplacement of [125I]NKA from human cloned NK2 receptor
ChEMBL 556 8 0 4 3.5 CN(Cc1ccc(F)cc1)C(=O)[C@@]1(c2ccc(Cl)c(Cl)c2)C[C@H]1CN1CCN(S(=O)(=O)N(C)C)CC1 10.1016/j.bmcl.2010.12.135
CHEMBL1682680 65096 0 None -9 3 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]NKA from human cloned NK2 receptorDisplacement of [125I]NKA from human cloned NK2 receptor
ChEMBL 556 8 0 4 3.5 CN(Cc1ccc(F)cc1)C(=O)[C@@]1(c2ccc(Cl)c(Cl)c2)C[C@H]1CN1CCN(S(=O)(=O)N(C)C)CC1 10.1016/j.bmcl.2010.12.135
86274487 166868 0 None -691 3 Human 5.1 pKi = 5.1 Binding
Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 408 2 0 7 3.6 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(Cl)c2)[C@@H]3C)n1 nan
CHEMBL4108583 166868 0 None -691 3 Human 5.1 pKi = 5.1 Binding
Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 408 2 0 7 3.6 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(Cl)c2)[C@@H]3C)n1 nan
10479619 119664 0 None - 1 Rat 7.1 pKi = 7.1 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 465 6 1 5 4.1 COC(=O)c1cccc(CN2CC3(CCN(CCc4c[nH]c5ccc(F)cc45)CC3)OC2=O)c1 10.1021/jm00019a006
CHEMBL331011 119664 0 None - 1 Rat 7.1 pKi = 7.1 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 465 6 1 5 4.1 COC(=O)c1cccc(CN2CC3(CCN(CCc4c[nH]c5ccc(F)cc45)CC3)OC2=O)c1 10.1021/jm00019a006
2110 9743 38 None -138 6 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysisDisplacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysis
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm5017413
219077 9743 38 None -138 6 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysisDisplacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysis
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm5017413
3480 9743 38 None -138 6 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysisDisplacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysis
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm5017413
CHEMBL346178 9743 38 None -138 6 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysisDisplacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysis
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm5017413
DB04872 9743 38 None -138 6 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysisDisplacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysis
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm5017413
44391066 70232 0 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 530 12 3 5 4.1 Cc1ccc(COc2ccc(NC(=O)N[C@@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc1 10.1016/j.bmcl.2004.11.045
CHEMBL179796 70232 0 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 530 12 3 5 4.1 Cc1ccc(COc2ccc(NC(=O)N[C@@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc1 10.1016/j.bmcl.2004.11.045
44390533 130647 0 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 584 12 3 5 4.9 O=C(Nc1ccc(OCc2ccc(C(F)(F)F)cc2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL362682 130647 0 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 584 12 3 5 4.9 O=C(Nc1ccc(OCc2ccc(C(F)(F)F)cc2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
44312702 109959 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 686 13 0 7 7.5 O=C(C1=C(c2ccccc2)OC2OC(COCc3ccccc3)C(OCc3ccccc3)C(OCc3ccccc3)C2[S+]1[O-])c1ccccc1 10.1016/s0960-894x(02)00471-7
CHEMBL308177 109959 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 686 13 0 7 7.5 O=C(C1=C(c2ccccc2)OC2OC(COCc3ccccc3)C(OCc3ccccc3)C(OCc3ccccc3)C2[S+]1[O-])c1ccccc1 10.1016/s0960-894x(02)00471-7
44312785 112191 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 502 9 1 8 2.8 CCOC(=O)C1=C(C)OC2OC(COCc3ccccc3)C(OCc3ccccc3)C(O)C2[S+]1[O-] 10.1016/s0960-894x(02)00471-7
CHEMBL311857 112191 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 502 9 1 8 2.8 CCOC(=O)C1=C(C)OC2OC(COCc3ccccc3)C(OCc3ccccc3)C(O)C2[S+]1[O-] 10.1016/s0960-894x(02)00471-7
44391078 69659 0 None - 1 Human 5.1 pKi = 5.1 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 529 12 2 5 4.1 CC(C)(Oc1ccc(-c2ccccc2)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL178451 69659 0 None - 1 Human 5.1 pKi = 5.1 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 529 12 2 5 4.1 CC(C)(Oc1ccc(-c2ccccc2)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
44390993 139187 0 None - 1 Human 5.1 pKi = 5.1 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 529 12 2 5 4.1 CC(C)(Oc1ccc(-c2ccccc2)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL369735 139187 0 None - 1 Human 5.1 pKi = 5.1 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 529 12 2 5 4.1 CC(C)(Oc1ccc(-c2ccccc2)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
10578880 16613 0 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 565 6 5 4 2.4 O=C1CC(Cc2ccccc2)C(=O)NCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm0010217
CHEMBL114036 16613 0 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 565 6 5 4 2.4 O=C1CC(Cc2ccccc2)C(=O)NCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm0010217
53472113 125636 0 None -398 5 Human 6.1 pKi = 6.1 Binding
Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysisDisplacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysis
ChEMBL 519 4 0 7 6.3 C[C@@H]1c2nnc(-c3csc(-c4ccc(F)cc4F)n3)n2CCN1C(=O)c1ccc(-c2cccs2)cc1 10.1021/jm5017413
CHEMBL3422009 125636 0 None -398 5 Human 6.1 pKi = 6.1 Binding
Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysisDisplacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysis
ChEMBL 519 4 0 7 6.3 C[C@@H]1c2nnc(-c3csc(-c4ccc(F)cc4F)n3)n2CCN1C(=O)c1ccc(-c2cccs2)cc1 10.1021/jm5017413
10578880 16613 0 None - 1 Human 6.1 pKi = 6.1 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 565 6 5 4 2.4 O=C1CC(Cc2ccccc2)C(=O)NCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm011127h
CHEMBL114036 16613 0 None - 1 Human 6.1 pKi = 6.1 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 565 6 5 4 2.4 O=C1CC(Cc2ccccc2)C(=O)NCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm011127h
44282001 106584 0 None -1 2 Human 8.1 pKi = 8.1 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 705 12 1 7 7.0 CO/N=C(\CN(C)C(=O)c1cc(OC)c(Br)c(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL285422 106584 0 None -1 2 Human 8.1 pKi = 8.1 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 705 12 1 7 7.0 CO/N=C(\CN(C)C(=O)c1cc(OC)c(Br)c(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281571 117166 0 None -1 2 Human 8.1 pKi = 8.1 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 718 10 2 5 8.7 CO/N=C(\CN(C)C(=O)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32430 117166 0 None -1 2 Human 8.1 pKi = 8.1 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 718 10 2 5 8.7 CO/N=C(\CN(C)C(=O)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281776 121029 0 None 3 2 Human 8.1 pKi = 8.1 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 568 11 1 5 7.3 CO/N=C(\COCc1cc(C)cc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33302 121029 0 None 3 2 Human 8.1 pKi = 8.1 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 568 11 1 5 7.3 CO/N=C(\COCc1cc(C)cc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44337202 14747 0 None 5 2 Human 8.1 pKi = 8.1 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 700 7 1 4 7.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)[C@H](c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL109053 14747 0 None 5 2 Human 8.1 pKi = 8.1 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 700 7 1 4 7.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)[C@H](c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
53317584 65264 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins
ChEMBL 640 13 2 6 5.4 COc1cc2ccccc2cc1C(=O)NC1(C(=O)N[C@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1 10.1016/j.bmcl.2011.01.074
CHEMBL1683153 65264 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins
ChEMBL 640 13 2 6 5.4 COc1cc2ccccc2cc1C(=O)NC1(C(=O)N[C@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1 10.1016/j.bmcl.2011.01.074
118724121 123188 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
ChEMBL 911 27 10 15 -0.5 CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)Nc1ccc([N+](=O)[O-])c2nonc12)C(C)C)C(N)=O 10.1021/jm401823z
CHEMBL3360200 123188 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
ChEMBL 911 27 10 15 -0.5 CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)Nc1ccc([N+](=O)[O-])c2nonc12)C(C)C)C(N)=O 10.1021/jm401823z
44380249 127122 0 None -3 2 Human 8.1 pKi = 8.1 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 706 12 1 6 7.3 CN(C/C(=N\OCc1c[nH]cn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL353027 127122 0 None -3 2 Human 8.1 pKi = 8.1 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 706 12 1 6 7.3 CN(C/C(=N\OCc1c[nH]cn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
23626253 175527 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 566 14 6 7 2.1 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCNC(CO)CO)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
CHEMBL437164 175527 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 566 14 6 7 2.1 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCNC(CO)CO)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
44380082 64889 0 None -12 2 Human 8.1 pKi = 8.1 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 683 13 1 6 6.7 CN(C/C(=N\OCCCN)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL167606 64889 0 None -12 2 Human 8.1 pKi = 8.1 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 683 13 1 6 6.7 CN(C/C(=N\OCCCN)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
20906619 67442 7 None -31 4 Human 5.1 pKi = 5.1 Binding
Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor
ChEMBL 396 4 1 4 3.7 COc1ccccc1N1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)n[nH]2)CC1 10.1016/j.bmcl.2011.02.033
CHEMBL1760338 67442 7 None -31 4 Human 5.1 pKi = 5.1 Binding
Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor
ChEMBL 396 4 1 4 3.7 COc1ccccc1N1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)n[nH]2)CC1 10.1016/j.bmcl.2011.02.033
9957749 187473 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 430 6 1 4 4.6 CC(C)NC(=O)c1c(CN2CCN(C(C)C)CC2)c(-c2ccccc2)nc2ccccc12 10.1021/jm000501v
CHEMBL47555 187473 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 430 6 1 4 4.6 CC(C)NC(=O)c1c(CN2CCN(C(C)C)CC2)c(-c2ccccc2)nc2ccccc12 10.1021/jm000501v
44266493 174187 0 None -53 2 Human 7.1 pKi = 7.1 Binding
Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 426 8 2 4 5.2 CC[C@@H](NC(=O)c1c(OCCO)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm980633c
CHEMBL429615 174187 0 None -53 2 Human 7.1 pKi = 7.1 Binding
Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 426 8 2 4 5.2 CC[C@@H](NC(=O)c1c(OCCO)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm980633c
44329001 214824 0 None - 1 Golden hamster 6.1 pKi = 6.1 Binding
Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)
ChEMBL 398 4 1 7 3.7 COC(=O)c1ccc2c(Nc3ccc(Cl)cc3)nc(N3CCOCC3)nc2c1 10.1016/0960-894X(95)00502-K
CHEMBL97520 214824 0 None - 1 Golden hamster 6.1 pKi = 6.1 Binding
Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)
ChEMBL 398 4 1 7 3.7 COC(=O)c1ccc2c(Nc3ccc(Cl)cc3)nc(N3CCOCC3)nc2c1 10.1016/0960-894X(95)00502-K
5764 10270 46 None -58 2 Human 5.1 pKi = 5.1 Binding
Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)
ChEMBL 396 5 1 4 4.5 COC(=O)[C@@H](c1ccccc1)NC(=O)c1cc(nc2c1cccc2)c1ccccc1 10.1021/jm9602423
6604858 10270 46 None -58 2 Human 5.1 pKi = 5.1 Binding
Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)
ChEMBL 396 5 1 4 4.5 COC(=O)[C@@H](c1ccccc1)NC(=O)c1cc(nc2c1cccc2)c1ccccc1 10.1021/jm9602423
CHEMBL9843 10270 46 None -58 2 Human 5.1 pKi = 5.1 Binding
Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)
ChEMBL 396 5 1 4 4.5 COC(=O)[C@@H](c1ccccc1)NC(=O)c1cc(nc2c1cccc2)c1ccccc1 10.1021/jm9602423
6604014 214627 7 None -28 2 Human 5.1 pKi = 5.1 Binding
Inhibition of [125I]neurokinin A (NKA) binding in human Tachykinin receptor 2 of chinese hamster ovary (hNK-2-CHO) cell membranes.Inhibition of [125I]neurokinin A (NKA) binding in human Tachykinin receptor 2 of chinese hamster ovary (hNK-2-CHO) cell membranes.
ChEMBL 396 5 1 4 4.5 COC(=O)[C@@H](NC(=O)c1cc(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm960818o
CHEMBL9643 214627 7 None -28 2 Human 5.1 pKi = 5.1 Binding
Inhibition of [125I]neurokinin A (NKA) binding in human Tachykinin receptor 2 of chinese hamster ovary (hNK-2-CHO) cell membranes.Inhibition of [125I]neurokinin A (NKA) binding in human Tachykinin receptor 2 of chinese hamster ovary (hNK-2-CHO) cell membranes.
ChEMBL 396 5 1 4 4.5 COC(=O)[C@@H](NC(=O)c1cc(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm960818o
2110 9743 38 None -138 6 Human 7.1 pKi = 7.1 Binding
Binding affinity to human NK2 receptor by radioligand binding assayBinding affinity to human NK2 receptor by radioligand binding assay
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1016/j.bmcl.2011.02.033
219077 9743 38 None -138 6 Human 7.1 pKi = 7.1 Binding
Binding affinity to human NK2 receptor by radioligand binding assayBinding affinity to human NK2 receptor by radioligand binding assay
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1016/j.bmcl.2011.02.033
3480 9743 38 None -138 6 Human 7.1 pKi = 7.1 Binding
Binding affinity to human NK2 receptor by radioligand binding assayBinding affinity to human NK2 receptor by radioligand binding assay
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1016/j.bmcl.2011.02.033
CHEMBL346178 9743 38 None -138 6 Human 7.1 pKi = 7.1 Binding
Binding affinity to human NK2 receptor by radioligand binding assayBinding affinity to human NK2 receptor by radioligand binding assay
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1016/j.bmcl.2011.02.033
DB04872 9743 38 None -138 6 Human 7.1 pKi = 7.1 Binding
Binding affinity to human NK2 receptor by radioligand binding assayBinding affinity to human NK2 receptor by radioligand binding assay
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1016/j.bmcl.2011.02.033
CHEMBL386783 219170 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligandBinding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligand
ChEMBL None None None CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](C)Nc1ccc([N+](=O)[O-])c2nonc12)C(N)=O 10.1021/jm00039a012
392622 63086 95 None 2 4 Human 6.1 pKi = 6.1 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 720 17 4 9 5.9 CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1 nan
CHEMBL163 63086 95 None 2 4 Human 6.1 pKi = 6.1 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 720 17 4 9 5.9 CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1 nan
11273015 65039 0 None -14 3 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]NKA from human cloned NK2 receptorDisplacement of [125I]NKA from human cloned NK2 receptor
ChEMBL 563 8 1 3 6.0 CC(=O)NC1(c2ccccc2)CCN(C[C@@H]2C[C@@]2(C(=O)N(C)Cc2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/j.bmcl.2010.12.135
CHEMBL1682624 65039 0 None -14 3 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]NKA from human cloned NK2 receptorDisplacement of [125I]NKA from human cloned NK2 receptor
ChEMBL 563 8 1 3 6.0 CC(=O)NC1(c2ccccc2)CCN(C[C@@H]2C[C@@]2(C(=O)N(C)Cc2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/j.bmcl.2010.12.135
28417 46813 49 None -1 12 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 337 0 1 3 4.2 C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C nan
CHEMBL1479 46813 49 None -1 12 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 337 0 1 3 4.2 C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C nan
2600 10551 74 None -6 13 Human 6.1 pKi = 6.1 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O nan
2608 10551 74 None -6 13 Human 6.1 pKi = 6.1 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O nan
5405 10551 74 None -6 13 Human 6.1 pKi = 6.1 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O nan
CHEMBL17157 10551 74 None -6 13 Human 6.1 pKi = 6.1 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O nan
DB00342 10551 74 None -6 13 Human 6.1 pKi = 6.1 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O nan
44281567 115997 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 554 11 1 5 7.0 CO/N=C(\COCc1ccc(C)cc1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32173 115997 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 554 11 1 5 7.0 CO/N=C(\COCc1ccc(C)cc1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
10032693 116539 0 None -2 2 Human 8.1 pKi = 8.1 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 703 10 1 5 8.3 CO/N=C(\CN(C)C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32309 116539 0 None -2 2 Human 8.1 pKi = 8.1 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 703 10 1 5 8.3 CO/N=C(\CN(C)C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
23625635 99595 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 647 11 4 5 3.3 O=C(Nc1ccc(I)cc1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1 10.1021/jm070289w
CHEMBL243725 99595 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 647 11 4 5 3.3 O=C(Nc1ccc(I)cc1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1 10.1021/jm070289w
9828448 108019 0 None 50 2 Human 8.0 pKi = 8.0 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 458 7 1 4 5.2 CC(C)C(C)NC(=O)c1c(CN2CCN(C(C)C)CC2)c(-c2ccccc2)nc2ccccc12 10.1021/jm000501v
CHEMBL296122 108019 0 None 50 2 Human 8.0 pKi = 8.0 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 458 7 1 4 5.2 CC(C)C(C)NC(=O)c1c(CN2CCN(C(C)C)CC2)c(-c2ccccc2)nc2ccccc12 10.1021/jm000501v
22405762 169932 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 474 9 0 3 5.9 CCC(=O)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
CHEMBL417940 169932 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 474 9 0 3 5.9 CCC(=O)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
23625787 156141 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 532 12 3 5 2.7 O=C(/C=C/c1ccccc1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1 10.1021/jm070289w
CHEMBL394531 156141 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 532 12 3 5 2.7 O=C(/C=C/c1ccccc1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1 10.1021/jm070289w
9939040 11782 7 None -2 4 Human 8.0 pKi = 8.0 Binding
In vitro binding affinity towards Human Tachykinin receptor 2In vitro binding affinity towards Human Tachykinin receptor 2
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
CHEMBL105060 11782 7 None -2 4 Human 8.0 pKi = 8.0 Binding
In vitro binding affinity towards Human Tachykinin receptor 2In vitro binding affinity towards Human Tachykinin receptor 2
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
22405734 206796 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 460 9 0 2 6.8 CCCC1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
CHEMBL59542 206796 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 460 9 0 2 6.8 CCCC1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
2726 7706 68 None -125 72 Human 5.0 pKi = 5.0 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C nan
621 7706 68 None -125 72 Human 5.0 pKi = 5.0 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C nan
83 7706 68 None -125 72 Human 5.0 pKi = 5.0 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C nan
CHEMBL71 7706 68 None -125 72 Human 5.0 pKi = 5.0 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C nan
DB00477 7706 68 None -125 72 Human 5.0 pKi = 5.0 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C nan
44363435 43962 0 None -1 2 Human 7.0 pKi = 7.0 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 785 14 0 5 9.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(Cc3ccccc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL145314 43962 0 None -1 2 Human 7.0 pKi = 7.0 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 785 14 0 5 9.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(Cc3ccccc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
23625474 159966 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 551 12 3 7 2.2 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1ccc([N+](=O)[O-])cc1 10.1021/jm070289w
CHEMBL397704 159966 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 551 12 3 7 2.2 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1ccc([N+](=O)[O-])cc1 10.1021/jm070289w
53232 195404 95 None 1 2 Human 5.0 pKi = 5.0 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 404 6 1 5 4.2 CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21 nan
CHEMBL503 195404 95 None 1 2 Human 5.0 pKi = 5.0 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 404 6 1 5 4.2 CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21 nan
104974 10248 31 None -7 7 Rat 6.0 pKi = 6.0 Binding
The compound was evaluated for the inhibition of [125I]NKA binding to Tachykinin receptor 2 from rat duodenum membranesThe compound was evaluated for the inhibition of [125I]NKA binding to Tachykinin receptor 2 from rat duodenum membranes
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(00)80694-0
2111 10248 31 None -7 7 Rat 6.0 pKi = 6.0 Binding
The compound was evaluated for the inhibition of [125I]NKA binding to Tachykinin receptor 2 from rat duodenum membranesThe compound was evaluated for the inhibition of [125I]NKA binding to Tachykinin receptor 2 from rat duodenum membranes
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(00)80694-0
3481 10248 31 None -7 7 Rat 6.0 pKi = 6.0 Binding
The compound was evaluated for the inhibition of [125I]NKA binding to Tachykinin receptor 2 from rat duodenum membranesThe compound was evaluated for the inhibition of [125I]NKA binding to Tachykinin receptor 2 from rat duodenum membranes
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(00)80694-0
CHEMBL308148 10248 31 None -7 7 Rat 6.0 pKi = 6.0 Binding
The compound was evaluated for the inhibition of [125I]NKA binding to Tachykinin receptor 2 from rat duodenum membranesThe compound was evaluated for the inhibition of [125I]NKA binding to Tachykinin receptor 2 from rat duodenum membranes
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(00)80694-0
DB06660 10248 31 None -7 7 Rat 6.0 pKi = 6.0 Binding
The compound was evaluated for the inhibition of [125I]NKA binding to Tachykinin receptor 2 from rat duodenum membranesThe compound was evaluated for the inhibition of [125I]NKA binding to Tachykinin receptor 2 from rat duodenum membranes
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(00)80694-0
44314486 112433 0 None -6 2 Human 7.0 pKi = 7.0 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 739 13 0 7 6.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC(N(C)C)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL312528 112433 0 None -6 2 Human 7.0 pKi = 7.0 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 739 13 0 7 6.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC(N(C)C)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
23625322 99084 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 534 11 3 6 2.7 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CC1)c1cc2ccccc2s1 10.1021/jm070289w
CHEMBL242848 99084 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 534 11 3 6 2.7 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CC1)c1cc2ccccc2s1 10.1021/jm070289w
44392318 129321 0 None -38018 2 Human 5.0 pKi = 5.0 Binding
Ki for human Neurokinin 2 receptorKi for human Neurokinin 2 receptor
ChEMBL 519 7 0 4 5.0 O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1C1(C2CC2)CCCC1 10.1016/j.bmcl.2005.05.134
CHEMBL360134 129321 0 None -38018 2 Human 5.0 pKi = 5.0 Binding
Ki for human Neurokinin 2 receptorKi for human Neurokinin 2 receptor
ChEMBL 519 7 0 4 5.0 O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1C1(C2CC2)CCCC1 10.1016/j.bmcl.2005.05.134
44550460 203816 0 None -69 4 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cellsDisplacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cells
ChEMBL 537 8 0 3 5.9 CC(=O)N(C)C1CCN(CCC(C)(C(=O)N(C)Cc2ccccc2Cl)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm900948q
CHEMBL567198 203816 0 None -69 4 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cellsDisplacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cells
ChEMBL 537 8 0 3 5.9 CC(=O)N(C)C1CCN(CCC(C)(C(=O)N(C)Cc2ccccc2Cl)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm900948q
44314547 109652 0 None -5 2 Human 6.0 pKi = 6.0 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 661 11 0 5 8.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL305826 109652 0 None -5 2 Human 6.0 pKi = 6.0 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 661 11 0 5 8.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
64143 205643 62 None -1 8 Human 5.0 pKi = 5.0 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 567 9 4 6 4.7 Cc1c(O)cccc1C(=O)N[C@@H](CSc1ccccc1)[C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C nan
CHEMBL584 205643 62 None -1 8 Human 5.0 pKi = 5.0 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 567 9 4 6 4.7 Cc1c(O)cccc1C(=O)N[C@@H](CSc1ccccc1)[C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C nan
2247 7293 81 None -44 42 Human 6.0 pKi = 6 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
249 7293 81 None -44 42 Human 6.0 pKi = 6 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
2603 7293 81 None -44 42 Human 6.0 pKi = 6 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
CHEMBL296419 7293 81 None -44 42 Human 6.0 pKi = 6 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
DB00637 7293 81 None -44 42 Human 6.0 pKi = 6 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
71549635 167653 0 None -1412 3 Human 5.0 pKi = 5 Binding
Binding Assay: The affinity of compounds of the invention for the NK2 receptor was evaluated in CHO recombinant cells which express the human NK2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK2 receptor was evaluated in CHO recombinant cells which express the human NK2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 450 4 0 8 4.4 C[C@@H]1c2nnc(-c3csc(N(C)C)n3)n2CCN1C(=O)c1ccc(-c2cccs2)cc1 nan
CHEMBL4115030 167653 0 None -1412 3 Human 5.0 pKi = 5 Binding
Binding Assay: The affinity of compounds of the invention for the NK2 receptor was evaluated in CHO recombinant cells which express the human NK2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK2 receptor was evaluated in CHO recombinant cells which express the human NK2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 450 4 0 8 4.4 C[C@@H]1c2nnc(-c3csc(N(C)C)n3)n2CCN1C(=O)c1ccc(-c2cccs2)cc1 nan
2112 7391 0 None - 1 Human 6.0 pKd = 6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7682062
2115 8628 19 None -8 3 Human 8.7 pKd = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 414 7 1 3 4.1 COC1(CCN(CC1)CCc1c[nH]c2c1cc(F)cc2)C[S@@](=O)c1ccccc1 7562907
2115 8628 19 None -8 3 Human 8.7 pKd = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 414 7 1 3 4.1 COC1(CCN(CC1)CCc1c[nH]c2c1cc(F)cc2)C[S@@](=O)c1ccccc1 7682062
2115 8628 19 None -8 3 Human 8.7 pKd = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 414 7 1 3 4.1 COC1(CCN(CC1)CCc1c[nH]c2c1cc(F)cc2)C[S@@](=O)c1ccccc1 7713168
9953599 8628 19 None -8 3 Human 8.7 pKd = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 414 7 1 3 4.1 COC1(CCN(CC1)CCc1c[nH]c2c1cc(F)cc2)C[S@@](=O)c1ccccc1 7562907
9953599 8628 19 None -8 3 Human 8.7 pKd = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 414 7 1 3 4.1 COC1(CCN(CC1)CCc1c[nH]c2c1cc(F)cc2)C[S@@](=O)c1ccccc1 7682062
9953599 8628 19 None -8 3 Human 8.7 pKd = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 414 7 1 3 4.1 COC1(CCN(CC1)CCc1c[nH]c2c1cc(F)cc2)C[S@@](=O)c1ccccc1 7713168
CHEMBL2110370 8628 19 None -8 3 Human 8.7 pKd = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 414 7 1 3 4.1 COC1(CCN(CC1)CCc1c[nH]c2c1cc(F)cc2)C[S@@](=O)c1ccccc1 7562907
CHEMBL2110370 8628 19 None -8 3 Human 8.7 pKd = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 414 7 1 3 4.1 COC1(CCN(CC1)CCc1c[nH]c2c1cc(F)cc2)C[S@@](=O)c1ccccc1 7682062
CHEMBL2110370 8628 19 None -8 3 Human 8.7 pKd = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 414 7 1 3 4.1 COC1(CCN(CC1)CCc1c[nH]c2c1cc(F)cc2)C[S@@](=O)c1ccccc1 7713168
2089 9542 28 None 102 5 Human 9.3 pKd = 9.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10455255
3795 9542 28 None 102 5 Human 9.3 pKd = 9.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10455255
5311311 9542 28 None 102 5 Human 9.3 pKd = 9.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10455255
CHEMBL217406 9542 28 None 102 5 Human 9.3 pKd = 9.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10455255
104974 10248 31 None -7 7 Rat 9.7 pKd = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 7719707
2111 10248 31 None -7 7 Rat 9.7 pKd = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 7719707
3481 10248 31 None -7 7 Rat 9.7 pKd = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 7719707
CHEMBL308148 10248 31 None -7 7 Rat 9.7 pKd = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 7719707
DB06660 10248 31 None -7 7 Rat 9.7 pKd = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 7719707
9850582 204021 22 125I-[MePhe7]-NKB -1 6 Human 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 None
CHEMBL56835 204021 22 125I-[MePhe7]-NKB -1 6 Human 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 None
9850582 204021 22 3H-NEUROKININ A -1 6 Human 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 None
CHEMBL56835 204021 22 3H-NEUROKININ A -1 6 Human 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 None
9850582 204021 22 125I-Iodohistidyl -1 6 Human 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 None
CHEMBL56835 204021 22 125I-Iodohistidyl -1 6 Human 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 None
None 222852 0 125I-Iodohistidyl -1 6 Human 9.3 pKi = 9.3 Binding
NoneNone
PDSP KiDatabase 1133 37 16 17 -4.6 CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CO)NC(=O)C(CC(=O)O)NC(=O)C(C(C)O)NC(=O)C(CCCCN)NC(=O)C(CC2=CN=CN2)N None
None 222852 0 125I-Iodohistidyl -1 6 Human 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 1133 37 16 17 -4.6 CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CO)NC(=O)C(CC(=O)O)NC(=O)C(C(C)O)NC(=O)C(CCCCN)NC(=O)C(CC2=CN=CN2)N None
9850582 204021 22 125I-Iodohistidyl 1 6 Bovine 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 None
CHEMBL56835 204021 22 125I-Iodohistidyl 1 6 Bovine 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 None
None 222852 0 125I-[MePhe7]-NKB -1 6 Human 9.1 pKi = 9.1 Binding
NoneNone
PDSP KiDatabase 1133 37 16 17 -4.6 CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CO)NC(=O)C(CC(=O)O)NC(=O)C(C(C)O)NC(=O)C(CCCCN)NC(=O)C(CC2=CN=CN2)N None
None 222852 0 125I-Iodohistidyl 1 6 Rat 9.1 pKi = 9.1 Binding
NoneNone
PDSP KiDatabase 1133 37 16 17 -4.6 CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CO)NC(=O)C(CC(=O)O)NC(=O)C(C(C)O)NC(=O)C(CCCCN)NC(=O)C(CC2=CN=CN2)N None
None 222852 0 125I-Iodohistidyl -1 6 Bovine 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase 1133 37 16 17 -4.6 CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CO)NC(=O)C(CC(=O)O)NC(=O)C(C(C)O)NC(=O)C(CCCCN)NC(=O)C(CC2=CN=CN2)N None
None 222852 0 125I-Iodohistidyl -1 6 Human 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 1133 37 16 17 -4.6 CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CO)NC(=O)C(CC(=O)O)NC(=O)C(C(C)O)NC(=O)C(CCCCN)NC(=O)C(CC2=CN=CN2)N None
None 222854 0 125I-Iodohistidyl-NKA -95 8 Rat 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 605 8 0 3 7.4 CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 None
202 8290 77 UNDEFINED -9 33 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
60835 8290 77 UNDEFINED -9 33 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
972 8290 77 UNDEFINED -9 33 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
CHEMBL1175 8290 77 UNDEFINED -9 33 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
DB00476 8290 77 UNDEFINED -9 33 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
5656 209845 87 UNDEFINED -7 43 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 277 5 1 3 3.0 COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1 None
CHEMBL637 209845 87 UNDEFINED -7 43 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 277 5 1 3 3.0 COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1 None
54841 209906 52 UNDEFINED -1 30 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 255 6 1 2 3.7 CNCC[C@@H](Oc1ccccc1C)c1ccccc1 None
CHEMBL641 209906 52 UNDEFINED -1 30 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 255 6 1 2 3.7 CNCC[C@@H](Oc1ccccc1C)c1ccccc1 None
3075702 224111 0 125I-NKA -2 37 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 198 3 1 3 1.5 C1CNC1COC2=CN=C(C=C2)Cl None
119376 8622 48 3H-NEUROKININ A -54954 27 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 393 7 1 6 1.6 O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C None
247 8622 48 3H-NEUROKININ A -54954 27 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 393 7 1 6 1.6 O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C None
CHEMBL33884 8622 48 3H-NEUROKININ A -54954 27 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 393 7 1 6 1.6 O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C None
3294 8787 111 125I-NKA -14454 44 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
71360 8787 111 125I-NKA -14454 44 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
87 8787 111 125I-NKA -14454 44 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
CHEMBL14376 8787 111 125I-NKA -14454 44 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
DB04946 8787 111 125I-NKA -14454 44 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
243 9976 91 3H-SR 48968 -1096 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
3052762 9976 91 3H-SR 48968 -1096 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
3502 9976 91 3H-SR 48968 -1096 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
CHEMBL117287 9976 91 3H-SR 48968 -1096 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
DB06480 9976 91 3H-SR 48968 -1096 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
21830793 98610 10 3H-8-OH-DPAT -66069 46 Bovine 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 373 7 0 8 0.6 COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1 None
CHEMBL2413154 98610 10 3H-8-OH-DPAT -66069 46 Bovine 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 373 7 0 8 0.6 COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1 None
44208932 147485 7 UNDEFINED -89125 37 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 475 5 1 3 6.8 Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1 None
CHEMBL381689 147485 7 UNDEFINED -89125 37 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 475 5 1 3 6.8 Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1 None
5079497 222853 0 125I-[MePhe7]-NKB -1445 3 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 841 26 8 10 -0.0 CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(CC1=CC=CC=C1)N(C)C(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(=O)O)NC(=O)CCC(=O)O None
None 222907 0 125I-Neurokinin A -1 13 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 164 3 1 3 0.8 C1CNC1COC2=CN=CC=C2 None
119380 222908 0 125I-Neurokinin A -1 8 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 166 1 0 3 1.8 CC1=NOC(=C1)C2CCCN2C None
None 223272 0 125I-NKA -10471285 17 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 372 2 1 3 4.4 CC(C)(C)C1=CC=C(C=C1)NC(=O)N2CCN(CC2)C3=C(C=CC=N3)Cl None
2098 10466 36 125I-[MePhe7]-NKB -457 6 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase None None None None None
36511 10466 36 125I-[MePhe7]-NKB -457 6 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase None None None None None
3805 10466 36 125I-[MePhe7]-NKB -457 6 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase None None None None None
3835 10466 36 125I-[MePhe7]-NKB -457 6 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase None None None None None
CHEMBL235363 10466 36 125I-[MePhe7]-NKB -457 6 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase None None None None None
133090 105199 20 125I-NKA -9 3 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 382 5 2 3 5.5 CCC(NC(=O)c1c(O)c(-c2ccccc2)nc2ccccc12)c1ccccc1 None
133090 105199 20 125I-[MePhe7]-NKB -9 3 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 382 5 2 3 5.5 CCC(NC(=O)c1c(O)c(-c2ccccc2)nc2ccccc12)c1ccccc1 None
CHEMBL275544 105199 20 125I-NKA -9 3 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 382 5 2 3 5.5 CCC(NC(=O)c1c(O)c(-c2ccccc2)nc2ccccc12)c1ccccc1 None
CHEMBL275544 105199 20 125I-[MePhe7]-NKB -9 3 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 382 5 2 3 5.5 CCC(NC(=O)c1c(O)c(-c2ccccc2)nc2ccccc12)c1ccccc1 None
None 222966 0 125I-Iodohistidyl -1023 5 Human 5.8 pKi = 5.8 Binding
NoneNone
PDSP KiDatabase 588 8 2 5 4.3 CN1C=C(C2=CC=CC=C21)C(=O)N3CC(CC3C(=O)NC(CC4=CC5=CC=CC=C5C=C4)C(=O)N(C)CC6=CC=CC=C6)O None
None 222851 0 125I-[MePhe7]-NKB -20 4 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 1210 38 14 16 -1.6 CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(=O)O)NC(=O)C(CC3=CN=CN3)NC(=O)C(CCSC)NC(=O)C(CC(=O)O)N None
None 222852 0 125I-Iodohistidyl -3 6 Guinea pig 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase 1133 37 16 17 -4.6 CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CO)NC(=O)C(CC(=O)O)NC(=O)C(C(C)O)NC(=O)C(CCCCN)NC(=O)C(CC2=CN=CN2)N None
None 222854 0 3H-NEUROKININ A -54 8 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 605 8 0 3 7.4 CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 None
None 222854 0 125I-Iodohistidyl-NKA -54 8 Human 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 605 8 0 3 7.4 CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 None
None 222854 0 125I-Iodohistidyl-NKA -95 8 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 605 8 0 3 7.4 CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 None
None 222967 0 125I-Iodohistidyl -3 6 Bovine 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 1041 17 10 13 0.9 CCCCCC1=CC=CC=C1CCC(=O)NC2C(OC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(=CC3=CC=C(C=C3)O)N(C2=O)C)CC(C)C)CC4=CC=CC=C4)C(C)O)CC(=O)N)CO)C None
None 222854 0 125I-NEUROPEPTIDE Y -95 8 Guinea pig 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 605 8 0 3 7.4 CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 None
None 222967 0 125I-Iodohistidyl -12 6 Human 5.4 pKi = 5.4 Binding
NoneNone
PDSP KiDatabase 1041 17 10 13 0.9 CCCCCC1=CC=CC=C1CCC(=O)NC2C(OC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(=CC3=CC=C(C=C3)O)N(C2=O)C)CC(C)C)CC4=CC=CC=C4)C(C)O)CC(=O)N)CO)C None
None 222854 0 125I-[MePhe7]-NKB -54 8 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 605 8 0 3 7.4 CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 None
None 222854 0 125I-NKA -54 8 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 605 8 0 3 7.4 CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 None
None 222967 0 125I-Iodohistidyl -12 6 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 1041 17 10 13 0.9 CCCCCC1=CC=CC=C1CCC(=O)NC2C(OC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(=CC3=CC=C(C=C3)O)N(C2=O)C)CC(C)C)CC4=CC=CC=C4)C(C)O)CC(=O)N)CO)C None
64143 205643 62 None -1 8 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 567 9 4 6 4.7 Cc1c(O)cccc1C(=O)N[C@@H](CSc1ccccc1)[C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C None
CHEMBL584 205643 62 None -1 8 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 567 9 4 6 4.7 Cc1c(O)cccc1C(=O)N[C@@H](CSc1ccccc1)[C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C None
53232 195404 95 None 1 2 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 404 6 1 5 4.2 CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21 None
CHEMBL503 195404 95 None 1 2 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 404 6 1 5 4.2 CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21 None
2726 7706 68 None -125 72 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
621 7706 68 None -125 72 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
83 7706 68 None -125 72 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
CHEMBL71 7706 68 None -125 72 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
DB00477 7706 68 None -125 72 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
28417 46813 49 None -1 12 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 337 0 1 3 4.2 C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C None
CHEMBL1479 46813 49 None -1 12 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 337 0 1 3 4.2 C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C None
1212 8443 50 None -389 65 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
204 8443 50 None -389 65 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
3372 8443 50 None -389 65 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
CHEMBL726 8443 50 None -389 65 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
DB00623 8443 50 None -389 65 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
176 7186 66 None -4 31 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 None
2157 7186 66 None -4 31 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 None
2566 7186 66 None -4 31 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 None
CHEMBL633 7186 66 None -4 31 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 None
DB01118 7186 66 None -4 31 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 None
3823 56995 42 None -36 11 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 530 7 0 7 4.2 CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 None
76973198 56995 42 None -36 11 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 530 7 0 7 4.2 CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 None
CHEMBL157101 56995 42 None -36 11 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 530 7 0 7 4.2 CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 None
2812 11551 101 None -28 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 None
CHEMBL104 11551 101 None -28 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 None
448537 167029 89 None -26 25 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 268 4 2 2 4.8 CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 None
CHEMBL411 167029 89 None -26 25 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 268 4 2 2 4.8 CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 None
657255 205863 34 None -17 15 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 337 12 2 3 5.6 CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1 None
CHEMBL588119 205863 34 None -17 15 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 337 12 2 3 5.6 CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1 None
441243 16608 58 None -19 8 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 670 12 5 7 3.1 CC(C)(C)NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2CN1C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)c1ccc2ccccc2n1 None
CHEMBL114 16608 58 None -19 8 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 670 12 5 7 3.1 CC(C)(C)NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2CN1C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)c1ccc2ccccc2n1 None
138106885 173690 75 None -1 4 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 853 10 4 14 3.7 CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C None
36314 173690 75 None -1 4 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 853 10 4 14 3.7 CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C None
CHEMBL428647 173690 75 None -1 4 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 853 10 4 14 3.7 CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C None
3198 212292 76 None -21 34 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 None
CHEMBL1201049 212292 76 None -21 34 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 None
CHEMBL808 212292 76 None -21 34 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 None
5362440 16793 63 None - 1 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 613 11 4 7 2.9 CC(C)(C)NC(=O)[C@@H]1CN(Cc2cccnc2)CCN1C[C@@H](O)C[C@@H](Cc1ccccc1)C(=O)N[C@H]1c2ccccc2C[C@H]1O None
CHEMBL115 16793 63 None - 1 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 613 11 4 7 2.9 CC(C)(C)NC(=O)[C@@H]1CN(Cc2cccnc2)CCN1C[C@@H](O)C[C@@H](Cc1ccccc1)C(=O)N[C@H]1c2ccccc2C[C@H]1O None
5318 22348 49 None -1 13 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 396 6 0 3 6.5 Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 None
CHEMBL1200348 22348 49 None -1 13 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 396 6 0 3 6.5 Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 None
CHEMBL1221 22348 49 None -1 13 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 396 6 0 3 6.5 Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 None
4189 213701 96 None -18 34 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 None
CHEMBL1559 213701 96 None -18 34 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 None
CHEMBL91 213701 96 None -18 34 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 None
2406 107180 89 None -16 12 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 354 2 2 3 5.9 Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O None
CHEMBL290106 107180 89 None -16 12 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 354 2 2 3 5.9 Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O None
1548955 95356 20 None -1 18 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 405 9 0 2 6.6 CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1 None
2800 95356 20 None -1 18 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 405 9 0 2 6.6 CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1 None
CHEMBL2355051 95356 20 None -1 18 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 405 9 0 2 6.6 CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1 None
1024 8072 71 None - 1 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central None None None None None
162639143 8072 71 None - 1 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central None None None None None
5284373 8072 71 None - 1 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central None None None None None
760 8072 71 None - 1 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central None None None None None
CHEMBL160 8072 71 None - 1 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central None None None None None
DB00091 8072 71 None - 1 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central None None None None None
3598 194600 76 None -1 7 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 404 2 2 2 6.6 Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl None
CHEMBL496 194600 76 None -1 7 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 404 2 2 2 6.6 Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl None
133 9274 52 None -165 43 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
1723 9274 52 None -165 43 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
28693 9274 52 None -165 43 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
CHEMBL19215 9274 52 None -165 43 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
DB13520 9274 52 None -165 43 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
2351 10059 64 None -13 21 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O None
2820 10059 64 None -13 21 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O None
5035 10059 64 None -13 21 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O None
CHEMBL81 10059 64 None -13 21 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O None
DB00481 10059 64 None -13 21 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O None
1836 9370 59 None -40 15 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 None
3340 9370 59 None -40 15 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 None
5281040 9370 59 None -40 15 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 None
CHEMBL787 9370 59 None -40 15 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 None
DB00471 9370 59 None -40 15 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 None
1016 10519 78 None -16 35 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 None
2561 10519 78 None -16 35 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 None
2733526 10519 78 None -16 35 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 None
5384 10519 78 None -16 35 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 None
CHEMBL83 10519 78 None -16 35 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 None
DB00675 10519 78 None -16 35 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 None
5353853 24758 47 None -14 15 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 427 6 0 4 6.1 Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 None
9556529 24758 47 None -14 15 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 427 6 0 4 6.1 Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 None
CHEMBL1262 24758 47 None -14 15 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 427 6 0 4 6.1 Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 None
2247 7293 81 None -44 42 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 None
249 7293 81 None -44 42 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 None
2603 7293 81 None -44 42 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 None
CHEMBL296419 7293 81 None -44 42 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 None
DB00637 7293 81 None -44 42 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 None
2600 10551 74 None -6 13 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O None
2608 10551 74 None -6 13 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O None
5405 10551 74 None -6 13 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O None
CHEMBL17157 10551 74 None -6 13 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O None
DB00342 10551 74 None -6 13 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O None
392622 63086 95 None 2 4 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 720 17 4 9 5.9 CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1 None
CHEMBL163 63086 95 None 2 4 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 720 17 4 9 5.9 CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1 None
2335 18620 22 None -3 12 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 None
8478 18620 22 None -3 12 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 None
CHEMBL1182210 18620 22 None -3 12 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 None
CHEMBL221753 18620 22 None -3 12 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 None
3191 109635 97 None -12 25 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 469 9 0 3 7.2 CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 None
CHEMBL305660 109635 97 None -12 25 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 469 9 0 3 7.2 CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 None
11057 182928 23 None -1 20 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 None
3468 182928 23 None -1 20 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 None
CHEMBL459265 182928 23 None -1 20 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 None
CHEMBL64894 182928 23 None -1 20 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 None
138106918 202265 42 None - 1 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 778 7 2 11 4.8 CCC1=C[C@@H]2CN(C1)Cc1c([nH]c3ccccc13)[C@@](C(=O)OC)(c1cc3c(cc1OC)N(C)[C@H]1[C@@](O)(C(=O)OC)[C@H](OC(C)=O)[C@]4(CC)C=CCN5CC[C@]31[C@@H]54)C2 None
5311497 202265 42 None - 1 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 778 7 2 11 4.8 CCC1=C[C@@H]2CN(C1)Cc1c([nH]c3ccccc13)[C@@](C(=O)OC)(c1cc3c(cc1OC)N(C)[C@H]1[C@@](O)(C(=O)OC)[C@H](OC(C)=O)[C@]4(CC)C=CCN5CC[C@]31[C@@H]54)C2 None
CHEMBL553025 202265 42 None - 1 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 778 7 2 11 4.8 CCC1=C[C@@H]2CN(C1)Cc1c([nH]c3ccccc13)[C@@](C(=O)OC)(c1cc3c(cc1OC)N(C)[C@H]1[C@@](O)(C(=O)OC)[C@H](OC(C)=O)[C@]4(CC)C=CCN5CC[C@]31[C@@H]54)C2 None
148124 213878 86 None - 1 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 807 8 5 14 3.3 CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@@H]12)C3(C)C None
CHEMBL3545252 213878 86 None - 1 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 807 8 5 14 3.3 CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@@H]12)C3(C)C None
CHEMBL92 213878 86 None - 1 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 807 8 5 14 3.3 CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@@H]12)C3(C)C None
3561 25849 39 None -1 11 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 360 2 0 1 4.4 Clc1cc(Cl)c(OCC#CI)cc1Cl None
CHEMBL1289 25849 39 None -1 11 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 360 2 0 1 4.4 Clc1cc(Cl)c(OCC#CI)cc1Cl None
9850582 204021 22 125I-Iodohistidyl -1 6 Human 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 None
CHEMBL56835 204021 22 125I-Iodohistidyl -1 6 Human 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 None
None 222854 0 125I-NEUROPEPTIDE Y -95 8 Guinea pig 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 605 8 0 3 7.4 CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 None
1973 210262 15 125I-NKA -3 36 Rat 5.1 pKi = 5.1 Binding
NoneNone
PDSP KiDatabase 462 3 1 7 3.9 Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 None
CHEMBL1394464 210262 15 125I-NKA -3 36 Rat 5.1 pKi = 5.1 Binding
NoneNone
PDSP KiDatabase 462 3 1 7 3.9 Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 None
CHEMBL66089 210262 15 125I-NKA -3 36 Rat 5.1 pKi = 5.1 Binding
NoneNone
PDSP KiDatabase 462 3 1 7 3.9 Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 None
5771 10921 0 None -17 2 Human 3.8 pKi = 3.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 471 5 2 8 2.7 O/N=C(/C(=O)N1CCN(CC1)c1nc(Nc2ccc(cc2)Cl)c2c(n1)C(=O)N(C2)C(C)C)\C 7562491
9847605 10921 0 None -17 2 Human 3.8 pKi = 3.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 471 5 2 8 2.7 O/N=C(/C(=O)N1CCN(CC1)c1nc(Nc2ccc(cc2)Cl)c2c(n1)C(=O)N(C2)C(C)C)\C 7562491
5771 10921 0 None 17 2 Guinea pig 5.1 pKi = 5.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 471 5 2 8 2.7 O/N=C(/C(=O)N1CCN(CC1)c1nc(Nc2ccc(cc2)Cl)c2c(n1)C(=O)N(C2)C(C)C)\C 7562491
9847605 10921 0 None 17 2 Guinea pig 5.1 pKi = 5.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 471 5 2 8 2.7 O/N=C(/C(=O)N1CCN(CC1)c1nc(Nc2ccc(cc2)Cl)c2c(n1)C(=O)N(C2)C(C)C)\C 7562491
107967 8427 0 None -1000 2 Human 6.1 pKi = 6.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 588 8 2 5 4.3 O[C@@H]1C[C@H](N(C1)C(=O)c1cn(c2c1cccc2)C)C(=O)N[C@H](C(=O)N(Cc1ccccc1)C)Cc1ccc2c(c1)cccc2 11937780
2114 8427 0 None -1000 2 Human 6.1 pKi = 6.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 588 8 2 5 4.3 O[C@@H]1C[C@H](N(C1)C(=O)c1cn(c2c1cccc2)C)C(=O)N[C@H](C(=O)N(Cc1ccccc1)C)Cc1ccc2c(c1)cccc2 11937780
CHEMBL1416993 8427 0 None -1000 2 Human 6.1 pKi = 6.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 588 8 2 5 4.3 O[C@@H]1C[C@H](N(C1)C(=O)c1cn(c2c1cccc2)C)C(=O)N[C@H](C(=O)N(Cc1ccccc1)C)Cc1ccc2c(c1)cccc2 11937780
2087 8701 0 None -28183 4 Human 6.3 pKi = 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
164286 10045 0 None - 1 Human 6.5 pKi = 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7682062
2118 10045 0 None - 1 Human 6.5 pKi = 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7682062
10327625 10896 0 None - 1 Human 6.8 pKi = 6.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 607 9 0 2 8.3 CC(Oc1cccc(c1)CC(=O)N1CCCC(C1)(CC[N+]1(C)CCC(CC1)c1ccccc1)c1ccc(c(c1)Cl)Cl)C 11937780
2122 10896 0 None - 1 Human 6.8 pKi = 6.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 607 9 0 2 8.3 CC(Oc1cccc(c1)CC(=O)N1CCCC(C1)(CC[N+]1(C)CCC(CC1)c1ccccc1)c1ccc(c(c1)Cl)Cl)C 11937780
2132 10516 58 None -97 6 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 382 5 2 3 5.5 CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1 9190866
5311424 10516 58 None -97 6 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 382 5 2 3 5.5 CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1 9190866
CHEMBL10188 10516 58 None -97 6 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 382 5 2 3 5.5 CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1 9190866
2110 9743 38 None -138 6 Human 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 12206858
2110 9743 38 None -138 6 Human 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 9190866
219077 9743 38 None -138 6 Human 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 12206858
219077 9743 38 None -138 6 Human 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 9190866
3480 9743 38 None -138 6 Human 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 12206858
3480 9743 38 None -138 6 Human 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 9190866
CHEMBL346178 9743 38 None -138 6 Human 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 12206858
CHEMBL346178 9743 38 None -138 6 Human 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 9190866
DB04872 9743 38 None -138 6 Human 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 12206858
DB04872 9743 38 None -138 6 Human 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 9190866
124003 9264 22 None - 1 Human 8.1 pKi = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7682062
2116 9264 22 None - 1 Human 8.1 pKi = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7682062
CHEMBL507824 9264 22 None - 1 Human 8.1 pKi = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7682062
2089 9542 28 None 102 5 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11137709
2089 9542 28 None 102 5 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
2089 9542 28 None 102 5 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7682062
2089 9542 28 None 102 5 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9190866
3795 9542 28 None 102 5 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11137709
3795 9542 28 None 102 5 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
3795 9542 28 None 102 5 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7682062
3795 9542 28 None 102 5 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9190866
5311311 9542 28 None 102 5 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11137709
5311311 9542 28 None 102 5 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
5311311 9542 28 None 102 5 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7682062
5311311 9542 28 None 102 5 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9190866
CHEMBL217406 9542 28 None 102 5 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11137709
CHEMBL217406 9542 28 None 102 5 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
CHEMBL217406 9542 28 None 102 5 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7682062
CHEMBL217406 9542 28 None 102 5 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9190866
2123 9540 0 None - 1 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 16979621
2123 9540 0 None - 1 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9484857
3086682 9540 0 None - 1 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 16979621
3086682 9540 0 None - 1 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9484857
2120 10893 0 None - 1 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 639 10 1 6 5.9 COc1cc(cc(c1OC)OC)C(=O)N(CC(c1ccc(c(c1)Cl)Cl)CCN1CCC2(CC1)NC(=O)Cc1c2cccc1)C 11937780
9852373 10893 0 None - 1 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 639 10 1 6 5.9 COc1cc(cc(c1OC)OC)C(=O)N(CC(c1ccc(c(c1)Cl)Cl)CCN1CCC2(CC1)NC(=O)Cc1c2cccc1)C 11937780
5778 10922 0 None - 1 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 516 8 1 3 5.1 O=C1NCCCN1C1CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C 22149761
9871234 10922 0 None - 1 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 516 8 1 3 5.1 O=C1NCCCN1C1CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C 22149761
5769 10297 5 None 194 2 Human 9.0 pKi = 9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 512 6 1 4 6.5 O=C(c1c(CN2CCC(CC2)N2CCCCC2)c(nc2c1cccc2)c1ccccc1)N[C@H](C(C)(C)C)C 11356103
9806459 10297 5 None 194 2 Human 9.0 pKi = 9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 512 6 1 4 6.5 O=C(c1c(CN2CCC(CC2)N2CCCCC2)c(nc2c1cccc2)c1ccccc1)N[C@H](C(C)(C)C)C 11356103
CHEMBL295770 10297 5 None 194 2 Human 9.0 pKi = 9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 512 6 1 4 6.5 O=C(c1c(CN2CCC(CC2)N2CCCCC2)c(nc2c1cccc2)c1ccccc1)N[C@H](C(C)(C)C)C 11356103
3901 9265 0 None - 1 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11063600
5311274 9265 0 None - 1 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11063600
104974 10248 31 None -7 7 Rat 9.3 pKi = 9.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 1313515
2111 10248 31 None -7 7 Rat 9.3 pKi = 9.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 1313515
3481 10248 31 None -7 7 Rat 9.3 pKi = 9.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 1313515
CHEMBL308148 10248 31 None -7 7 Rat 9.3 pKi = 9.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 1313515
DB06660 10248 31 None -7 7 Rat 9.3 pKi = 9.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 1313515
104974 10248 31 None 1 7 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 12206858
104974 10248 31 None 1 7 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 7682062
104974 10248 31 None 1 7 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 9190866
2111 10248 31 None 1 7 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 12206858
2111 10248 31 None 1 7 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 7682062
2111 10248 31 None 1 7 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 9190866
3481 10248 31 None 1 7 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 12206858
3481 10248 31 None 1 7 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 7682062
3481 10248 31 None 1 7 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 9190866
CHEMBL308148 10248 31 None 1 7 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 12206858
CHEMBL308148 10248 31 None 1 7 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 7682062
CHEMBL308148 10248 31 None 1 7 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 9190866
DB06660 10248 31 None 1 7 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 12206858
DB06660 10248 31 None 1 7 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 7682062
DB06660 10248 31 None 1 7 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 9190866
3882 8638 0 None - 1 Human 9.8 pKi = 9.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8027981
6324620 8638 0 None - 1 Human 9.8 pKi = 9.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8027981
10483085 10894 0 None - 1 Human 9.9 pKi = 9.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 567 7 1 3 6.0 O=C1Cc2ccccc2C2(N1)CCN(CC2)CCC(c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccc(cc1)F)C 11937780
2121 10894 0 None - 1 Human 9.9 pKi = 9.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 567 7 1 3 6.0 O=C1Cc2ccccc2C2(N1)CCN(CC2)CCC(c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccc(cc1)F)C 11937780
11527495 8749 19 None - 1 Human 10.1 pKi None 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 644 11 3 6 5.2 O=C([C@H](NC(=O)C1(CCCC1)NC(=O)c1cc2c(s1)cc(cc2)C)Cc1ccccc1)NCC1CCN(CC1)CC1CCOCC1 16979621
2117 8749 19 None - 1 Human 10.1 pKi None 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 644 11 3 6 5.2 O=C([C@H](NC(=O)C1(CCCC1)NC(=O)c1cc2c(s1)cc(cc2)C)Cc1ccccc1)NCC1CCN(CC1)CC1CCOCC1 16979621
CHEMBL266125 8749 19 None - 1 Human 10.1 pKi None 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 644 11 3 6 5.2 O=C([C@H](NC(=O)C1(CCCC1)NC(=O)c1cc2c(s1)cc(cc2)C)Cc1ccccc1)NCC1CCN(CC1)CC1CCOCC1 16979621
DB12042 8749 19 None - 1 Human 10.1 pKi None 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 644 11 3 6 5.2 O=C([C@H](NC(=O)C1(CCCC1)NC(=O)c1cc2c(s1)cc(cc2)C)Cc1ccccc1)NCC1CCN(CC1)CC1CCOCC1 16979621
2090 9543 25 None -38 4 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7682062
2090 9543 25 None -38 4 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9190866
5311312 9543 25 None -38 4 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7682062
5311312 9543 25 None -38 4 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9190866
CHEMBL437797 9543 25 None -38 4 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7682062
CHEMBL437797 9543 25 None -38 4 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9190866
2098 10466 36 None -457 6 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
2098 10466 36 None -457 6 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7682062
2098 10466 36 None -457 6 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9190866
36511 10466 36 None -457 6 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
36511 10466 36 None -457 6 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7682062
36511 10466 36 None -457 6 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9190866
3805 10466 36 None -457 6 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
3805 10466 36 None -457 6 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7682062
3805 10466 36 None -457 6 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9190866
3835 10466 36 None -457 6 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
3835 10466 36 None -457 6 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7682062
3835 10466 36 None -457 6 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9190866
CHEMBL235363 10466 36 None -457 6 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
CHEMBL235363 10466 36 None -457 6 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7682062
CHEMBL235363 10466 36 None -457 6 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9190866
2113 9868 0 None -199 3 Human 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9190866
2106 10319 4 None -1 3 Human 9.4 pKi None 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 711 12 1 6 6.4 CO/N=C(/[C@@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)N1CCC[C@@H](C1=O)CC(=O)NC)\CN(C(=O)c1cc(Cl)cc(c1)Cl)C 12206858
9875034 10319 4 None -1 3 Human 9.4 pKi None 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 711 12 1 6 6.4 CO/N=C(/[C@@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)N1CCC[C@@H](C1=O)CC(=O)NC)\CN(C(=O)c1cc(Cl)cc(c1)Cl)C 12206858
CHEMBL77023 10319 4 None -1 3 Human 9.4 pKi None 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 711 12 1 6 6.4 CO/N=C(/[C@@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)N1CCC[C@@H](C1=O)CC(=O)NC)\CN(C(=O)c1cc(Cl)cc(c1)Cl)C 12206858